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Apurba Bhattacharjee

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Apurba K Bhattacharjee; Sarah A Evans; Dmitry Pervitsky; James W Pomponio; Richard Gordon
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Apurba K Bhattacharjee; Kamil Kuca; Kamil Musilek; Richard Gordon
An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning.
Apurba K Bhattacharjee; Ha Thu Le; Elizabeth Marek; Richard Gordon
Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase.

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2013: Apurba K Bhattacharjee; Sarah A Evans; Dmitry Pervitsky; James W Pomponio; Richard Gordon
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Bioorganic & medicinal chemistry 2013;21(9):2651-62.
2012: Apurba K Bhattacharjee; Kamil Kuca; Kamil Musilek; Richard Gordon
An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2012;8(2):230-45.
2012: Apurba K Bhattacharjee; Ha Thu Le; Elizabeth Marek; Richard Gordon
Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase.
European journal of medicinal chemistry 2012;49():229-38.
2011: Clare E Gutteridge; Marshall M Hoffman; Apurba K Bhattacharjee; Wilbur K Milhous; Lucia Gerena
In vitro efficacy of 7-benzylamino-1-isoquinolinamines against Plasmodium falciparum related to the efficacy of chalcones.
Bioorganic & medicinal chemistry letters 2011;21(2):786-9.
2010: Wilbur H Chen; subhendu basu; Apurba K Bhattacharjee; Alan S Cross
Enhanced antibody responses to a detoxified lipopolysaccharide-group B meningococcal outer membrane protein vaccine are due to synergistic engagement of Toll-like receptors.
Innate immunity 2010;16(5):322-32.
2010: Apurba K Bhattacharjee; Kamil Kuca; Kamil Musilek; Richard Gordon
In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties.
Chemical research in toxicology 2010;23(1):26-36.
2009: Apurba K Bhattacharjee; Jonathan A Gordon; Elizabeth Marek; Amy Campbell; Richard Gordon
3D-QSAR studies of 2,2-diphenylpropionates to aid discovery of novel potent muscarinic antagonists.
Bioorganic & medicinal chemistry 2009;17(11):3999-4012.
2008: Wilbur H Chen; Tae Jin Kang; Apurba K Bhattacharjee; Alan S Cross
Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia.
Innate immunity 2008;14(5):269-78.
2008: Mina J Izadjoo; Mark G Mense; Apurba K Bhattacharjee; Ted L Hadfield; R M Crawford; David L Hoover
A study on the use of male animal models for developing a live vaccine for brucellosis.
Transboundary and emerging diseases 2008;55(3-4):145-51.
2007: Apurba K Bhattacharjee
In silico three-dimensional pharmacophores for aiding the discovery of the Pfmrk (Plasmodium cyclin-dependent protein kinases) specific inhibitors for the therapeutic treatment of malaria.
Expert opinion on drug discovery 2007;2(8):1115-27.
2007: Apurba K Bhattacharjee; Daniel A Nichols; Lucia Gerena; Norma Roncal; Clare E Gutteridge
An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(4):317-26.
2007: Clare E Gutteridge; J V Vo; C B Tillett; J A Vigilante; J R Dettmer; S L Patterson; Karl A Werbovetz; J Capers; Daniel A Nichols; Apurba K Bhattacharjee; Lucia Gerena
Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(2):115-9.
2007: Jayendra B Bhonsle; Apurba K Bhattacharjee; Raj K Gupta
Novel semi-automated methodology for developing highly predictive QSAR models: application for development of QSAR models for insect repellent amides.
Journal of molecular modeling 2007;13(1):179-208.
2006: Geoffrey S Dow; Tiffany N Heady; Apurba K Bhattacharjee; Diana Caridha; Lucia Gerena; Montip Gettayacamin; C A Lanteri; Nicanor Obaldia; Norma Roncal; Todd W Shearer; Philip L Smith; A Tungtaeng; Lesley Wolf; M Cabezas; Debra L Yourick; Kirsten S Smith
Utility of alkylaminoquinolinyl methanols as new antimalarial drugs.
Antimicrobial agents and chemotherapy 2006;50(12):4132-43.
2006: Clare E Gutteridge; Daniel A Nichols; Sean M Curtis; Darshan S Thota; Joseph V Vo; Lucia Gerena; Gettayacamin Montip; Constance O Asher; Damaris S Diaz; Charles A DiTusa; Kirsten S Smith; Apurba K Bhattacharjee
In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.
Bioorganic & medicinal chemistry letters 2006;16(21):5682-6.
2006: Apurba K Bhattacharjee; Mina J Izadjoo; Wendell D Zollinger; Mikeljon P Nikolich; David L Hoover
Comparison of protective efficacy of subcutaneous versus intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine.
Infection and immunity 2006;74(10):5820-5.
2006: Carmen M Fernandez-Prada; Elzbieta B Zelazowska; Apurba K Bhattacharjee; Mikeljon P Nikolich; David L Hoover
Identification of smooth and rough forms in cultures of Brucella melitensis strains by flow cytometry.
Journal of immunological methods 2006;315(1-2):162-70.
2006: Dawn A Delfín; Apurba K Bhattacharjee; Adam J Yakovich; Karl A Werbovetz
Activity of and initial mechanistic studies on a novel antileishmanial agent identified through in silico pharmacophore development and database searching.
Journal of medicinal chemistry 2006;49(14):4196-207.
2006: Xuan Z Ding; Ian Paulsen; Apurba K Bhattacharjee; Mikeljon P Nikolich; Garry S A Myers; David L Hoover
A high efficiency cloning and expression system for proteomic analysis.
Proteomics 2006;6(14):4038-46.
2005: Steven M Opal; John E Palardy; Wilbur H Chen; Nicolas A Parejo; Apurba K Bhattacharjee; Alan S Cross
Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms.
The Journal of infectious diseases 2005;192(12):2074-80.
2005: Apurba K Bhattacharjee; Raj K Gupta
Analysis of molecular stereoelectronic similarity between N,N-diethyl-m-toluamide (DEET) analogs and insect juvenile hormone to develop a model pharmacophore for insect repellent activity.
Journal of the American Mosquito Control Association 2005;21(4 Suppl):23-9.
2005: Rickey P Hicks; Mark G Hartell; Daniel A Nichols; Apurba K Bhattacharjee; John E van Hamont; Donald R Skillman
The medicinal chemistry of botulinum, ricin and anthrax toxins.
Current medicinal chemistry 2005;12(6):667-90.
2004: Apurba K Bhattacharjee; Jeanne A Geyer; Cassandra L Woodard; April K Kathcart; Daniel A Nichols; Sean T Prigge; Zhiyu Li; Bryan T Mott; Norman C Waters
A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.
Journal of medicinal chemistry 2004;47(22):5418-26.
2004: Rickey P Hicks; Apurba K Bhattacharjee; Brandon W Koser; Daniel D Traficante
The anthrax protective antigen (PA63) bound conformation of a peptide inhibitor of the binding of lethal factor to PA63: as determined by trNOESY NMR and molecular modeling.
Journal of medicinal chemistry 2004;47(22):5347-55.
2004: Mark G Hartell; Rickey Hicks; Apurba K Bhattacharjee; Brandon W Koser; Keith Carvalho; John E van Hamont
Nuclear magnetic resonance and molecular modeling analysis of the interaction of the antimalarial drugs artelinic acid and artesunic acid with beta-cyclodextrin.
Journal of pharmaceutical sciences 2004;93(8):2076-89.
2004: Geoffrey S Dow; Michael L Koenig; Lesley Wolf; Lucia Gerena; Miriam Lopez-Sanchez; Thomas H Hudson; Apurba K Bhattacharjee
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Antimicrobial agents and chemotherapy 2004;48(7):2624-32.
2004: Mina J Izadjoo; Apurba K Bhattacharjee; Chrysanthi M Paranavitana; Ted L Hadfield; David L Hoover
Oral vaccination with Brucella melitensis WR201 protects mice against intranasal challenge with virulent Brucella melitensis 16M.
Infection and immunity 2004;72(7):4031-9.
2004: Apurba K Bhattacharjee; Mark G Hartell; Daniel A Nichols; Rickey P Hicks; Benjamin Stanton; John E van Hamont; Wilbur K Milhous
Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates.
European journal of medicinal chemistry 2004;39(1):59-67.
2003: Alan S Cross; Steven M Opal; John E Palardy; Joseph J Drabick; H Shaw Warren; Christian Huber; Pamela Cook; Apurba K Bhattacharjee
Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects.
Vaccine 2003;21(31):4576-87.
2003: Cassandra L Woodard; Zhiyu Li; April K Kathcart; James Terrell; Lucia Gerena; Miriam Lopez-Sanchez; Dennis E Kyle; Apurba K Bhattacharjee; Daniel A Nichols; William Ellis; Sean T Prigge; Jeanne A Geyer; Norman C Waters
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.
Journal of medicinal chemistry 2003;46(18):3877-82.
2003: Yacov Ashani; Apurba K Bhattacharjee; Haim Leader; Ashima Saxena; Bhupendra P Doctor
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.
Biochemical pharmacology 2003;66(2):191-202.
2003: Srinivasa R Cheruku; Souvik Maiti; Arnulf Dorn; Bernard Scorneaux; Apurba K Bhattacharjee; William Y Ellis; Jonathan L Vennerstrom
Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth.
Journal of medicinal chemistry 2003;46(14):3166-9.
2003: Rickey P Hicks; Erin Mones; Hanah Kim; Brandon W Koser; Daniel A Nichols; Apurba K Bhattacharjee
Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles.
Biopolymers 2003;68(4):459-70.
2003: Alan S Cross; Serhan Sakarya; Salahaldin Rifat; Thomas K Held; Beth-Ellen Drysdale; Philippe A Grange; Frederick J Cassels; Lai-Xi Wang; Nicholas M Stamatos; Ann Farese; Daniel Casey; Jan Powell; Apurba K Bhattacharjee; Michael E Kleinberg; Simeon E Goldblum
Recruitment of murine neutrophils in vivo through endogenous sialidase activity.
The Journal of biological chemistry 2003;278(6):4112-20.
2002: Apurba K Bhattacharjee; Dennis E Kyle; Jonathan L Vennerstrom; Wilbur K Milhous
A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal.
Journal of chemical information and computer sciences 2002;42(5):1212-20.
2002: Alice N Neely; Apurba K Bhattacharjee; George Babcock; Ian Alan Holder; Alan S Cross
Differential effects of two different routes of immunization on protection against gram-negative sepsis by a detoxified Escherichia coli J5 lipopolysaccharide group B meningococcal outer membrane protein complex vaccine in a burned mouse model.
The Journal of burn care & rehabilitation 2002;23(5):333-40.
2002: Michael A Riel; Dennis E Kyle; Apurba K Bhattacharjee; Wilbur K Milhous
Efficacy of proton pump inhibitor drugs against Plasmodium falciparum in vitro and their probable pharmacophores.
Antimicrobial agents and chemotherapy 2002;46(8):2627-32.
2002: Apurba K Bhattacharjee; Lillian Van de Verg; Mina J Izadjoo; Liang Yuan; Ted L Hadfield; Wendell D Zollinger; David L Hoover
Protection of mice against brucellosis by intranasal immunization with Brucella melitensis lipopolysaccharide as a noncovalent complex with Neisseria meningitidis group B outer membrane protein.
Infection and immunity 2002;70(7):3324-9.
2002: Apurba K Bhattacharjee; David J Skanchy; Barton Jennings; Thomas H Hudson; James J Brendle; Karl A Werbovetz
Analysis of stereoelectronic properties, mechanism of action and pharmacophore of synthetic indolo[2,1-b]quinazoline-6,12-dione derivatives in relation to antileishmanial activity using quantum chemical, cyclic voltammetry and 3-D-QSAR CATALYST procedures.
Bioorganic & medicinal chemistry 2002;10(6):1979-89.
2001: X Z Ding; Carmen M Fernandez-Prada; Apurba K Bhattacharjee; David L Hoover
Over-expression of hsp-70 inhibits bacterial lipopolysaccharide-induced production of cytokines in human monocyte-derived macrophages.
Cytokine 2001;16(6):210-9.
2001: Apurba K Bhattacharjee; Dennis E Kyle; Jonathan L Vennerstrom
Structural analysis of chloroquine resistance reversal by imipramine analogs.
Antimicrobial agents and chemotherapy 2001;45(9):2655-7.
2001: Alan S Cross; Steven M Opal; H Shaw Warren; John E Palardy; K Glaser; Nicolas A Parejo; Apurba K Bhattacharjee
Active immunization with a detoxified Escherichia coli J5 lipopolysaccharide group B meningococcal outer membrane protein complex vaccine protects animals from experimental sepsis.
The Journal of infectious diseases 2001;183(7):1079-86.
2001: Mark G Mense; Lillian Van de Verg; Apurba K Bhattacharjee; J L Garrett; J A Hart; Luther E Lindler; Ted L Hadfield; David L Hoover
Bacteriologic and histologic features in mice after intranasal inoculation of Brucella melitensis.
American journal of veterinary research 2001;62(3):398-405.
2000: Mina J Izadjoo; Y Polotsky; Mark G Mense; Apurba K Bhattacharjee; Chrysanthi M Paranavitana; Ted L Hadfield; David L Hoover
Impaired control of Brucella melitensis infection in Rag1-deficient mice.
Infection and immunity 2000;68(9):5314-20.
2000: Karl A Werbovetz; Apurba K Bhattacharjee; James J Brendle; J P Scovill
Analysis of stereoelectronic properties of camptothecin analogues in relation to biological activity.
Bioorganic & medicinal chemistry 2000;8(7):1741-7.
2000: Apurba K Bhattacharjee; Raj K Gupta; D Ma; Jean M Karle
Molecular similarity analysis between insect juvenile hormone and N, N-diethyl-m-toluamide (DEET) analogs may aid design of novel insect repellents.
Journal of molecular recognition : JMR 2000;13(4):213-20.
2000: Kevin J McCullough; James K Wood; Apurba K Bhattacharjee; Yuxiang Dong; Dennis E Kyle; Wilbur K Milhous; Jonathan L Vennerstrom
Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.
Journal of medicinal chemistry 2000;43(6):1246-9.
2000: M O Eze; L Yuan; RM Crawford; Chrysanthi M Paranavitana; Ted L Hadfield; Apurba K Bhattacharjee; RL Warren; David L Hoover
Effects of opsonization and gamma interferon on growth of Brucella melitensis 16M in mouse peritoneal macrophages in vitro.
Infection and immunity 2000;68(1):257-63.
1999: SR Vippagunta; Arnulf Dorn; Hugues Matile; Apurba K Bhattacharjee; Jean M Karle; William Y Ellis; RG Ridley; Jonathan L Vennerstrom
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.
Journal of medicinal chemistry 1999;42(22):4630-9.
1999: David L Hoover; RM Crawford; Lillian Van de Verg; Mina J Izadjoo; Apurba K Bhattacharjee; Chrysanthi M Paranavitana; RL Warren; Mikeljon P Nikolich; Ted L Hadfield
Protection of mice against brucellosis by vaccination with Brucella melitensis WR201(16MDeltapurEK).
Infection and immunity 1999;67(11):5877-84.
1999: Alan S Cross; Steven M Opal; Apurba K Bhattacharjee; S T Donta; Peter Peduzzi; Emil Fürer; John U Que; Stanley J Cryz
Immunotherapy of sepsis: flawed concept or faulty implementation?
Vaccine 1999;17 Suppl 2():S13-21.
1999: Jean M Karle; Apurba K Bhattacharjee
Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity.
Bioorganic & medicinal chemistry 1999;7(9):1769-74.
1999: Apurba K Bhattacharjee; Alan S Cross
Vaccines and antibodies in the prevention and treatment of sepsis.
Infectious disease clinics of North America 1999;13(2):355-69, vii.
1999: Apurba K Bhattacharjee; Jean M Karle
Stereoelectronic properties of antimalarial artemisinin analogues in relation to neurotoxicity.
Chemical research in toxicology 1999;12(5):422-8.
1999: D Ma; Apurba K Bhattacharjee; Raj K Gupta; Jean M Karle
Predicting mosquito repellent potency of N,N-diethyl-m-toluamide (DEET) analogs from molecular electronic properties.
The American journal of tropical medicine and hygiene 1999;60(1):1-6.
1998: Apurba K Bhattacharjee; Jean M Karle
Functional correlation of molecular electronic properties with potency of synthetic carbinolamine antimalarial agents.
Bioorganic & medicinal chemistry 1998;6(10):1927-33.
1998: Douglas D Bannerman; M J Fitzpatrick; D Y Anderson; Apurba K Bhattacharjee; T J Novitsky; Jeffrey D Hasday; Alan S Cross; Simeon E Goldblum
Endotoxin-neutralizing protein protects against endotoxin-induced endothelial barrier dysfunction.
Infection and immunity 1998;66(4):1400-7.
1998: Joseph J Drabick; Apurba K Bhattacharjee; David L Hoover; G E Siber; V E Morales; L D Young; S L Brown; Alan S Cross
Covalent polymyxin B conjugate with human immunoglobulin G as an antiendotoxin reagent.
Antimicrobial agents and chemotherapy 1998;42(3):583-8.
1996: L L Van De Verg; Antoinette B Hartman; Apurba K Bhattacharjee; BD Tall; L Yuan; K Sasala; T L Hadfield; Wendell D Zollinger; David L Hoover; RL Warren
Outer membrane protein of Neisseria meningitidis as a mucosal adjuvant for lipopolysaccharide of Brucella melitensis in mouse and guinea pig intranasal immunization models.
Infection and immunity 1996;64(12):5263-8.
1996: Apurba K Bhattacharjee; Jean M Karle
Molecular electronic properties of a series of 4-quinolinecarbinolamines define antimalarial activity profile.
Journal of medicinal chemistry 1996;39(23):4622-9.
1996: Apurba K Bhattacharjee; Steven M Opal; R Taylor; R Naso; M Semenuk; Wendell D Zollinger; Ellen E Moran; L Young; C Hammack; J C Sadoff; Alan S Cross
A noncovalent complex vaccine prepared with detoxified Escherichia coli J5 (Rc chemotype) lipopolysaccharide and Neisseria meningitidis Group B outer membrane protein produces protective antibodies against gram-negative bacteremia.
The Journal of infectious diseases 1996;173(5):1157-63.
1994: Apurba K Bhattacharjee; Steven M Opal; John E Palardy; Joseph J Drabick; H Collins; R Taylor; A Cotton; Alan S Cross
Affinity-purified Escherichia coli J5 lipopolysaccharide-specific IgG protects neutropenic rats against gram-negative bacterial sepsis.
The Journal of infectious diseases 1994;170(3):622-9.
1990: Apurba K Bhattacharjee; J C Sadoff; H Collins; Alan S Cross; A H Khalil; Marcia M Bieber; C Wright; Nelson N Teng
Synthesis and characterization of gentiobiose heptaacetate conjugate vaccines that produce endotoxin-neutralizing antibodies.
Bioconjugate chemistry 1990;1(6):375-80.
1990: Apurba K Bhattacharjee; Ellen E Moran; Wendell D Zollinger
Antibodies to meningococcal H.8 (Lip) antigen fail to show bactericidal activity.
Canadian journal of microbiology 1990;36(2):117-22.
1988: Apurba K Bhattacharjee; Ellen E Moran; J S Ray; Wendell D Zollinger
Purification and characterization of H.8 antigen from group B Neisseria meningitidis.
Infection and immunity 1988;56(4):773-8.