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Giulio Muccioli

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Lucie Geurts; Giulio G Muccioli; Nathalie M Delzenne; Patrice Cani
Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia.
Jamal El Bakali; Christophe Furman; Pauline Gilleron; Frédérique Klupsch; Didier M Lambert; Emmanuelle Lipka; Roxane Mansouri; Virginie Andrzejak; Amélie Barczyk; Mathilde Body-Malapel; Philippe CHAVATTE; Pierre Desreumaux; Madjid Djouina; Giulio G Muccioli; Régis Millet
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
L B Bindels; Pedro Buc Calderon; Patrice Cani; E M Dewulf; O Feron; J C Martin; Giulio G Muccioli; Audrey M Neyrinck; P Porporato; K P Scott; Pierre Sonveaux; Julien Verrax; Nathalie M Delzenne
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver.

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All Publications

2013: Lucie Geurts; Giulio G Muccioli; Nathalie M Delzenne; Patrice Cani
Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia.
PloS one 2013;8(2):e55963.
2012: Jamal El Bakali; Christophe Furman; Pauline Gilleron; Frédérique Klupsch; Didier M Lambert; Emmanuelle Lipka; Roxane Mansouri; Virginie Andrzejak; Amélie Barczyk; Mathilde Body-Malapel; Philippe CHAVATTE; Pierre Desreumaux; Madjid Djouina; Giulio G Muccioli; Régis Millet
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
Journal of medicinal chemistry 2012;55(20):8948-52.
2012: L B Bindels; Pedro Buc Calderon; Patrice Cani; E M Dewulf; O Feron; J C Martin; Giulio G Muccioli; Audrey M Neyrinck; P Porporato; K P Scott; Pierre Sonveaux; Julien Verrax; Nathalie M Delzenne
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver.
British journal of cancer 2012;107(8):1337-44.
2012: Mireille Alhouayek; Giulio G Muccioli
The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity.
Trends in molecular medicine 2012;18(10):615-25.
2012: Coco N Kapanda; Geoffray Labar; Julien Masquelier; Giulio G Muccioli; Jacques H Poupaert; Didier M Lambert
Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.
Journal of medicinal chemistry 2012;55(12):5774-83.
2012: Barbara Bosier; Didier M Lambert; Birgit Mertens; Yvette Michotte; Giulio G Muccioli; Sophie Sarre; Emmanuel Hermans
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.
Neuropharmacology 2012;62(7):2328-36.
2012: Marion Feledziak; Didier M Lambert; Jacqueline Marchand-Brynaert; Giulio G Muccioli
Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis.
Recent patents on CNS drug discovery 2012;7(1):49-70.
2012: Nicolas Matuszak; Giulio G Muccioli; Jacques H Poupaert; Brigitte Baldeyroux; Laurie Hamtiaux; Amélie Lansiaux; Didier M Lambert
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;45(3):263-71.
2012: Laurie Hamtiaux; Caroline Bouzin; Olivier Feron; Bernard Gallez; Julien Masquelier; Giulio G Muccioli; Didier M Lambert
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
BMC cancer 2012;12():92.
2011: Marion Feledziak; Didier M Lambert; Giulio G Muccioli; Jacqueline Marchand-Brynaert
SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.
Journal of medicinal chemistry 2011;54(19):6812-23.
2011: William R Marrs; Giulio G Muccioli; Silvia Ortega-Gutierrez; Jose Antonio Cisneros; Eric A Horne; Yi Hsing Lin; Maria L Lopez-Rodriguez; Cong Xu; Nephi Stella
Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.
The Journal of biological chemistry 2011;286(33):28723-8.
2011: Nele Evens; Didier M Lambert; Giulio G Muccioli; Koen Van Laere; Caroline Vandeputte; Alfons M Verbruggen; Veerle Baekelandt; zeger debyser; Guy M Bormans
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.
Bioorganic & medicinal chemistry 2011;19(15):4499-505.
2011: Evelyne M Dewulf; Marc Francaux; Yvan Larondelle; Eric Mignolet; Giulio G Muccioli; Audrey M Neyrinck; Barbara D Pachikian; Sam Possemiers; Florence M Sohet; Ann Van Holle; Laure B Bindels; Patrice Cani; Louise Deldicque; Nathalie M Delzenne
Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.
The Journal of nutritional biochemistry 2011;22(8):712-22.
2011: Clémentine Thabuis; Delphine Tissot-Favre; Giulio G Muccioli; Frédéric Destaillats; Touafiq Harach; Didier M Lambert; Matthieu Maillot; Jean-Charles Martin
Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice.
Journal of lipid research 2011;52(7):1373-82.
2011: Virginie Andrzejak; Mathilde Body-Malapel; Philippe CHAVATTE; Pierre Desreumaux; Madjid Djouina; Jamal El Bakali; Didier M Lambert; Giulio G Muccioli; Nicolas Renault; Régis Millet
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
Bioorganic & medicinal chemistry 2011;19(12):3777-86.
2011: Michelle Sexton; Grace Woodruff; Eric A Horne; Yi Hsing Lin; Giulio G Muccioli; Mingfeng Bai; Eric Stern; Darryl J Bornhop; Nephi Stella
NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening.
Chemistry & biology 2011;18(5):563-8.
2011: Thibaut Duparc; Damien Naslain; André Colom; Giulio G Muccioli; Nicolas Massaly; Nathalie M Delzenne; Philippe Valet; Patrice Cani; Claude Knauf
Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.
Antioxidants & redox signaling 2011;14(3):415-23.
2011: Laurie Hamtiaux; Laurie Hansoulle; Nicolas Dauguet; Bernard Gallez; Giulio G Muccioli; Didier M Lambert
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
PloS one 2011;6(10):e26823.
2011: Barbara D Pachikian; Laurence Portois; Florence M Sohet; Patrice Cani; Yvon A Carpentier; Emilie Catry; Fabienne C De Backer; Nicolas Dejeans; Louise Deldicque; Jean-Baptiste Demoulin; Evelyne M Dewulf; Ahmed Essaghir; Fabienne Foufelle; Marc Francaux; Isabelle Leclercq; Olivier Molendi-Coste; Giulio G Muccioli; Audrey M Neyrinck; Nathalie M Delzenne
Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.
PloS one 2011;6(8):e23365.
2010: Jamal El Bakali; Giulio G Muccioli; Nicolas Renault; Delphine Pradal; Mathilde Body-Malapel; Madjid Djouina; Laurie Hamtiaux; Virginie Andrzejak; Pierre Desreumaux; Philippe CHAVATTE; Didier M Lambert; Régis Millet
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series.
Journal of medicinal chemistry 2010;53(22):7918-31.
2010: François Collard; Vincent Stroobant; Pedro Lamosa; Coco N Kapanda; Didier M Lambert; Giulio G Muccioli; Jacques H Poupaert; Fred Opperdoes; Emile Van Schaftingen
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
The Journal of biological chemistry 2010;285(39):29826-33.
2010: Frédéric De Wael; Giulio G Muccioli; Didier M Lambert; Thérèse Sergent; Yves-Jacques Schneider; Jean-François Rees; Jacqueline Marchand-Brynaert
Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors.
European journal of medicinal chemistry 2010;45(9):3564-74.
2010: William R Marrs; Jacqueline L Blankman; Eric A Horne; Aurore Thomazeau; Yi Hsing Lin; Jonathan Coy; Agnes L Bodor; Giulio G Muccioli; Sherry Shu-Jung Hu; Grace Woodruff; Susan Fung; Mathieu Lafourcade; Jessica P Alexander; Jonathan Z Long; Weiwei Li; Cong Xu; Thomas Möller; Ken Mackie; Olivier Jacques MANZONI; Benjamin F Cravatt; Nephi Stella
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Nature neuroscience 2010;13(8):951-7.
2010: Giulio G Muccioli; Damien Naslain; Fredrik Bäckhed; Christopher S Reigstad; Didier M Lambert; Nathalie M Delzenne; Patrice Cani
The endocannabinoid system links gut microbiota to adipogenesis.
Molecular systems biology 2010;6():392.
2010: Leonie Wyffels; Giulio G Muccioli; Coco N Kapanda; Geoffray Labar; Sylvie De Bruyne; Filip De Vos; Didier M Lambert
PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue.
Nuclear medicine and biology 2010;37(5):665-75.
2010: Barbara Bosier; Giulio G Muccioli; Emmanuel Hermans; Didier M Lambert
Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities.
Biochemical pharmacology 2010;80(1):1-12.
2010: Giulio G Muccioli
Endocannabinoid biosynthesis and inactivation, from simple to complex.
Drug discovery today 2010;15(11-12):474-83.
2009: Nicolas Matuszak; Giulio G Muccioli; Geoffray Labar; Didier M Lambert
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
Journal of medicinal chemistry 2009;52(23):7410-20.
2009: Coco N Kapanda; Giulio G Muccioli; Geoffray Labar; Jacques H Poupaert; Didier M Lambert
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
Journal of medicinal chemistry 2009;52(22):7310-4.
2009: Marion Feledziak; Catherine Michaux; Allan Urbach; Geoffray Labar; Giulio G Muccioli; Didier M Lambert; Jacqueline Marchand-Brynaert
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.
Journal of medicinal chemistry 2009;52(22):7054-68.
2009: Leonie Wyffels; Giulio G Muccioli; Sylvie De Bruyne; Lieselotte Moerman; Johan Sambre; Didier M Lambert; Filip De Vos
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain.
Journal of medicinal chemistry 2009;52(15):4613-22.
2009: Nele Evens; Giulio G Muccioli; Nele Houbrechts; Didier M Lambert; Alfons M Verbruggen; Koen Van Laere; Guy M Bormans
Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging.
Nuclear medicine and biology 2009;36(4):455-65.
2009: Giulio G Muccioli; Angela Sia; Paul J Muchowski; Nephi Stella
Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae.
PloS one 2009;4(6):e5942.
2008: Giulio G Muccioli; Geoffray Labar; Didier M Lambert
CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay.
Chembiochem : a European journal of chemical biology 2008;9(16):2704-10.
2008: Allan Urbach; Giulio G Muccioli; Eric Stern; Didier M Lambert; Jacqueline Marchand-Brynaert
3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(14):4163-7.
2008: Giulio G Muccioli; Nephi Stella
An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain.
Analytical biochemistry 2008;373(2):220-8.
2008: Giulio G Muccioli; Nephi Stella
Microglia produce and hydrolyze palmitoylethanolamide.
Neuropharmacology 2008;54(1):16-22.
2007: Didier M Lambert; Giulio G Muccioli
Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players.
Current opinion in clinical nutrition and metabolic care 2007;10(6):735-44.
2007: Eric Stern; Giulio G Muccioli; Barbara Bosier; Laurie Hamtiaux; Régis Millet; Jacques H Poupaert; Jean-Pierre Hénichart; Patrick Depreux; Jean-François Goossens; Didier M Lambert
Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.
Journal of medicinal chemistry 2007;50(22):5471-84.
2007: Giulio G Muccioli
Blocking the cannabinoid receptors: drug candidates and therapeutic promises.
Chemistry & biodiversity 2007;4(8):1805-27.
2007: Sara Hoet; Luc Pieters; Giulio G Muccioli; Jean-Louis Habib-Jiwan; Fred R Opperdoes; Joëlle Quetin-Leclercq
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.
Journal of natural products 2007;70(8):1360-3.
2007: Geoffray Labar; Cédric Bauvois; Giulio G Muccioli; Johan Wouters; Didier M Lambert
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling.
Chembiochem : a European journal of chemical biology 2007;8(11):1293-7.
2007: Giulio G Muccioli; Cong Xu; Emma Odah; Eiron Cudaback; Jose Antonio Cisneros; Didier M Lambert; María Luz López Rodríguez; Sandra M Bajjalieh; Nephi Stella
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(11):2883-9.
2006: Catherine Michaux; Giulio G Muccioli; Didier M Lambert; Johan Wouters
Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104.
Bioorganic & medicinal chemistry letters 2006;16(18):4772-6.
2006: Giulio G Muccioli; Johan Wouters; Caroline Charlier; Gerhard K E Scriba; Teresa Pizza; Pierluigi Di Pace; Paolo De Martino; Wolfgang Poppitz; Jacques H Poupaert; Didier M Lambert
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.
Journal of medicinal chemistry 2006;49(3):872-82.
2006: Giulio G Muccioli; Nicola Fazio; Gerhard K E Scriba; Wolfgang Poppitz; Fabio Cannata; Jacques H Poupaert; Johan Wouters; Didier M Lambert
Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.
Journal of medicinal chemistry 2006;49(1):417-25.
2006: Eric Stern; Giulio G Muccioli; Régis Millet; Jean-François Goossens; Amaury Farce; Philippe CHAVATTE; Jacques H Poupaert; Didier M Lambert; Patrick Depreux; Jean-Pierre Hénichart
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.
Journal of medicinal chemistry 2006;49(1):70-9.
2005: Giulio G Muccioli; Johan Wouters; Gerhard K E Scriba; Wolfgang Poppitz; Jacques H Poupaert; Didier M Lambert
1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.
Journal of medicinal chemistry 2005;48(23):7486-90.
2005: Giulio G Muccioli; Diana Martin; Gerhard K E Scriba; Wolfgang Poppitz; Jacques H Poupaert; Johan Wouters; Didier M Lambert
Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.
Journal of medicinal chemistry 2005;48(7):2509-17.
2005: Giulio G Muccioli; Didier M Lambert
Current knowledge on the antagonists and inverse agonists of cannabinoid receptors.
Current medicinal chemistry 2005;12(12):1361-94.
2004: Sophie J Govaerts; Giulio G Muccioli; Emmanuel Hermans; Didier M Lambert
Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors.
European journal of pharmacology 2004;495(1):43-53.
2003: Giulio G Muccioli; Johan Wouters; Jacques H Poupaert; Bernadette Norberg; Wolfgang Poppitz; Gerhard K E Scriba; Didier M Lambert
Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins.
Organic letters 2003;5(20):3599-602.