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Richard Upton

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Richard N Upton; Lona L Christrup; Ola Dale; David J R Foster; Kristin Moksnes; Lars Popper
A physiologically-based recirculatory meta-model for nasal fentanyl in man.
Trine Andresen; Richard N Upton; David J R Foster; Lona L Christrup; Lars Arendt-Nielsen; Asbjørn Mohr Drewes
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
Richard N Upton; Andrew A Somogyi; A M Martinez; J Colvill; Cliff Grant
Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep.

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2012: Richard N Upton; Lona L Christrup; Ola Dale; David J R Foster; Kristin Moksnes; Lars Popper
A physiologically-based recirculatory meta-model for nasal fentanyl in man.
Journal of pharmacokinetics and pharmacodynamics 2012;39(5):561-76.
2011: Trine Andresen; Richard N Upton; David J R Foster; Lona L Christrup; Lars Arendt-Nielsen; Asbjørn Mohr Drewes
Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.
Basic & clinical pharmacology & toxicology 2011;108(4):274-84.
2010: Richard N Upton; Andrew A Somogyi; A M Martinez; J Colvill; Cliff Grant
Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep.
British journal of anaesthesia 2010;105(6):798-809.
2010: Xiaoxin Qi; Allan M Evans; Jiping Wang; John O Miners; Richard N Upton; Robert W Milne
Inhibition of morphine metabolism by ketamine.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(5):728-31.
2010: Sarah J Capper; Susan Loo; Jason P Geue; Richard N Upton; Jennifer Ong; Pamela E Macintyre; Guy L Ludbrook
Pharmacokinetics of fentanyl after subcutaneous administration in volunteers.
European journal of anaesthesiology 2010;27(3):241-6.
2009: Richard N Upton; Allison M Martinez; Cliff Grant
Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheep.
British journal of anaesthesia 2009;103(6):848-57.
2008: Mette L Jensen; Per Sjøgren; Richard N Upton; David J R Foster; Peter Bonde; Christian Graae; Ulrik Skram; Lene Stevner; Lona L Christrup
Pharmacokinetic-pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers.
Basic & clinical pharmacology & toxicology 2008;103(1):94-101.
2008: Richard N Upton; Mads Rasmussen; Cliff Grant; Allison M Martinez; Georg E Cold; Guy L Ludbrook
Pharmacokinetics and pharmacodynamics of indomethacin: effects on cerebral blood flow in anaesthetized sheep.
Clinical and experimental pharmacology & physiology 2008;35(3):317-23.
2007: Mette L Jensen; David J R Foster; Richard N Upton; Kim Kristensen; Steen H Hansen; Niels-Henrik Jensen; Bettina N Nielsen; Ulrik Skram; Hanne H Villesen; Lona L Christrup
Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers.
European journal of clinical pharmacology 2007;63(12):1153-9.
2007: Richard N Upton
Cerebral uptake of drugs in humans.
Clinical and experimental pharmacology & physiology 2007;34(8):695-701.
2006: Hanne H Villesen; David J R Foster; Richard N Upton; Lona L Christrup; Andrew A Somogyi; A Martinez; Cliff Grant
Blood-brain distribution of morphine-6-glucuronide in sheep.
British journal of pharmacology 2006;149(6):754-60.
2006: Hanne H Villesen; David J R Foster; Richard N Upton; Andrew A Somogyi; Allison Martinez; Cliff Grant
Cerebral kinetics of oxycodone in conscious sheep.
Journal of pharmaceutical sciences 2006;95(8):1666-76.
2006: Mads Rasmussen; Richard N Upton; Cliff Grant; Allison M Martinez; Georg E Cold; Guy L Ludbrook
The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension.
Anesthesia and analgesia 2006;102(6):1823-9.
2006: David J R Foster; Mette L Jensen; Richard N Upton; Andrew A Somogyi; Cliff Grant; Allison Martinez
Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation.
British journal of pharmacology 2006;147(2):209-17.
2005: David J Doolette; Richard N Upton; Cliff Grant
Countercurrent compartmental models describe hind limb skeletal muscle helium kinetics at resting and low blood flows in sheep.
Acta physiologica Scandinavica 2005;185(2):109-21.
2005: David J R Foster; Richard N Upton; Andrew A Somogyi; Cliff Grant; Allison Martinez
The acute disposition of (R)- and (s)-methadone in brain and lung of sheep.
Journal of pharmacokinetics and pharmacodynamics 2005;32(3-4):547-70.
2005: Richard N Upton; Guy L Ludbrook
A physiologically based, recirculatory model of the kinetics and dynamics of propofol in man.
Anesthesiology 2005;103(2):344-52.
2005: David J Doolette; Richard N Upton; Allison M Martinez
Brain pharmacokinetics of lignocaine before and following intravenous perfluorocarbon emulsion infusion in sheep.
Clinical and experimental pharmacology & physiology 2005;32(5-6):367-71.
2005: David J Doolette; Richard N Upton; Cliff Grant
Perfusion-diffusion compartmental models describe cerebral helium kinetics at high and low cerebral blood flows in sheep.
The Journal of physiology 2005;563(Pt 2):529-39.
2005: Richard N Upton; Guy L Ludbrook
Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs - method development and application to magnesium in sheep.
BMC pharmacology 2005;5():5.
2004: Richard N Upton; Cliff Grant; Allison M Martinez; Guy L Ludbrook
Recirculatory model of fentanyl disposition with the brain as the target organ.
British journal of anaesthesia 2004;93(5):687-97.
2004: Richard N Upton
The two-compartment recirculatory pharmacokinetic model--an introduction to recirculatory pharmacokinetic concepts.
British journal of anaesthesia 2004;92(4):475-84.
2004: Richard N Upton
Calculating the hybrid (macro) rate constants of a three-compartment mamillary pharmacokinetic model from known micro-rate constants.
Journal of pharmacological and toxicological methods 2004;49(1):65-8.
2003: Guy L Ludbrook; Richard N Upton
Pharmacokinetic drug interaction between propofol and remifentanil?
Anesthesia and analgesia 2003;97(3):924-5.
2003: John A Myburgh; Richard N Upton; Cliff Grant; Allison Martinez
The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under isoflurane anaesthesia in an ovine model.
Anaesthesia and intensive care 2003;31(3):259-66.
2003: Richard N Upton; Guy L Ludbrook; Allison M Martinez; Cliff Grant; R W Milne
Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions.
British journal of anaesthesia 2003;90(6):750-8.
2003: Da Zheng; Richard N Upton; Allison M Martinez
The contribution of the coronary concentrations of propofol to its cardiovascular effects in anesthetized sheep.
Anesthesia and analgesia 2003;96(6):1589-97, table of contents.
2003: John A Myburgh; Richard N Upton; Cliff Grant; Allison Martinez
The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under propofol anaesthesia in an ovine model.
Intensive care medicine 2003;29(5):817-24.
2003: Yi Fei Huang; Richard N Upton
The effect of hypoxic hypoxia on the systemic and myocardial pharmacokinetics and dynamics of lidocaine in sheep.
Journal of pharmaceutical sciences 2003;92(1):180-9.
2002: John A Myburgh; Richard N Upton; Cliff Grant; Allison Martinez
The cerebrovascular effects of adrenaline, noradrenaline and dopamine infusions under propofol and isoflurane anaesthesia in sheep.
Anaesthesia and intensive care 2002;30(6):725-33.
2002: Guy L Ludbrook; Richard N Upton
Determinants of drug onset.
Current opinion in anaesthesiology 2002;15(4):409-14.
2002: John A Myburgh; Richard N Upton; Guy L Ludbrook; Allison Martinez; Cliff Grant
Cerebrovascular carbon dioxide reactivity in sheep: effect of propofol or isoflurane anaesthesia.
Anaesthesia and intensive care 2002;30(4):413-21.
2002: Richard N Upton
Theoretical aspects of P-glycoprotein mediated drug efflux on the distribution volume of anaesthetic-related drugs in the brain.
Anaesthesia and intensive care 2002;30(2):183-91.
2002: Richard N Upton; David J Doolette
A quantitative alternative to the hysteresis plot for measurement of drug transit time.
Journal of pharmacological and toxicological methods 2002;47(1):45-51.
2001: D J Williams; David J Doolette; Richard N Upton
Increased cerebral blood flow and cardiac output following cerebral arterial air embolism in sheep.
Clinical and experimental pharmacology & physiology 2001;28(11):868-72.
2001: Guy L Ludbrook; PE Macintyre; H Douglas; L Ong; Richard N Upton
A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation.
Anaesthesia 2001;56(8):739-44.
2001: David J Doolette; Richard N Upton; D Zheng
Diffusion-limited tissue equilibration and arteriovenous diffusion shunt describe skeletal muscle nitrous oxide kinetics at high and low blood flows in sheep.
Acta physiologica Scandinavica 2001;172(3):167-77.
2001: D Zheng; Richard N Upton; Guy L Ludbrook; A Martinez
Acute cardiovascular effects of magnesium and their relationship to systemic and myocardial magnesium concentrations after short infusion in awake sheep.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1176-83.
2001: Richard N Upton; Guy L Ludbrook; Cliff Grant; Allison Martinez
In vivo cerebral pharmacokinetics and pharmacodynamics of diazepam and midazolam after short intravenous infusion administration in sheep.
Journal of pharmacokinetics and pharmacodynamics 2001;28(2):129-53.
2001: Richard N Upton; Guy L Ludbrook; Cliff Grant
The cerebral and systemic kinetics of thiopentone and propofol in halothane anaesthetized sheep.
Anaesthesia and intensive care 2001;29(2):117-23.
2001: John A Myburgh; Richard N Upton; Cliff Grant; Allison Martinez
Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine model.
Intensive care medicine 2001;27(1):276-82.
2000: Richard N Upton; Guy L Ludbrook; Cliff Grant; David J Doolette
The effect of altered cerebral blood flow on the cerebral kinetics of thiopental and propofol in sheep.
Anesthesiology 2000;93(4):1085-94.
2000: D Zheng; David J Doolette; Richard N Upton
In vivo manipulation and continuous measurement of muscle blood flow with venous effluent sampling.
Clinical and experimental pharmacology & physiology 2000;27(8):625-9.
2000: Richard N Upton
Relationships between steady state blood concentrations and cardiac output during intravenous infusions.
Biopharmaceutics & drug disposition 2000;21(2):69-76.
1999: David J Doolette; Richard N Upton; Cliff Grant
Agreement between ultrasonic Doppler venous outflow and Kety and Schmidt estimates of cerebral blood flow.
Clinical and experimental pharmacology & physiology 1999;26(9):736-40.
1999: Richard N Upton; Guy L Ludbrook; Cliff Grant; Allison M Martinez
Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration.
Anesthesia and analgesia 1999;89(3):545-52.
1999: Richard N Upton; Yi Fei Huang; LE Mather; David J Doolette
The relationship between the myocardial kinetics of meperidine and its effect on myocardial contractility: model-independent analysis and optimal regional model.
The Journal of pharmacology and experimental therapeutics 1999;290(2):694-701.
1999: Guy L Ludbrook; Richard N Upton; Cliff Grant; A Martinez
A compartmental analysis of the pharmacokinetics of propofol in sheep.
Journal of pharmacokinetics and biopharmaceutics 1999;27(3):329-38.
1999: Richard N Upton; Guy L Ludbrook
A model of the kinetics and dynamics of induction of anaesthesia in sheep: variable estimation for thiopental and comparison with propofol.
British journal of anaesthesia 1999;82(6):890-9.
1999: Richard N Upton; David J Doolette
Kinetic aspects of drug disposition in the lungs.
Clinical and experimental pharmacology & physiology 1999;26(5-6):381-91.
1999: Guy L Ludbrook; M F James; Richard N Upton
The effect of magnesium sulfate on cerebral blood flow velocity, cardiovascular variables, and arterial carbon dioxide tension in awake sheep.
Journal of neurosurgical anesthesiology 1999;11(2):96-101.
1999: Guy L Ludbrook; Richard N Upton; C Grant; A Martinez
Prolonged dysequilibrium between blood and brain concentrations of propofol during infusions in sheep.
Acta anaesthesiologica Scandinavica 1999;43(2):206-11.
1998: David J Doolette; Richard N Upton; Cliff Grant
Diffusion-limited, but not perfusion-limited, compartmental models describe cerebral nitrous oxide kinetics at high and low cerebral blood flows.
Journal of pharmacokinetics and biopharmaceutics 1998;26(6):649-72.
1998: Yi Fei Huang; D Zheng; Richard N Upton; E Gray; Cliff Grant
Tachycardia alone fails to change the myocardial pharmacokinetics and dynamics of lidocaine, thiopental, and verapamil after intravenous bolus administration in sheep.
Journal of pharmaceutical sciences 1998;87(7):854-8.
1998: Guy L Ludbrook; Richard N Upton; Cliff Grant; Allison Martinez
The effect of rate of administration on brain concentrations of propofol in sheep.
Anesthesia and analgesia 1998;86(6):1301-6.
1998: D Zheng; Richard N Upton; Allison M Martinez; Cliff Grant; Guy L Ludbrook
The influence of the bolus injection rate of propofol on its cardiovascular effects and peak blood concentrations in sheep.
Anesthesia and analgesia 1998;86(5):1109-15.
1998: Yi Fei Huang; Richard N Upton; D Zheng; C McLean; EC Gray; Cliff Grant
The enantiomer-specific kinetics and dynamics of verapamil after rapid intravenous administration to sheep: physiological analysis and modeling.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1048-57.
1998: John A Myburgh; Richard N Upton; Cliff Grant; Allison Martinez
A comparison of the effects of norepinephrine, epinephrine, and dopamine on cerebral blood flow and oxygen utilisation.
Acta neurochirurgica. Supplement 1998;71():19-21.
1997: Yi Fei Huang; Richard N Upton; EC Gray; Cliff Grant; D Zheng; Guy L Ludbrook
The effects of short intravenous infusions of thiopentone on myocardial function, blood flow and oxygen consumption in sheep.
Anaesthesia and intensive care 1997;25(6):627-33.
1997: Guy L Ludbrook; Richard N Upton
A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements.
British journal of anaesthesia 1997;79(4):505-13.
1997: Richard N Upton; Guy L Ludbrook
A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables.
British journal of anaesthesia 1997;79(4):497-504.
1997: Richard N Upton; TJ Semple; PE Macintyre
Pharmacokinetic optimisation of opioid treatment in acute pain therapy.
Clinical pharmacokinetics 1997;33(3):225-44.
1997: Richard N Upton; Guy L Ludbrook; EC Gray; Cliff Grant
The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep.
Anesthesiology 1997;86(6):1317-25.
1997: TJ Semple; Richard N Upton; PE Macintyre; William B Runciman; LE Mather
Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula.
Anaesthesia 1997;52(4):318-23.
1997: Guy L Ludbrook; M Hitchcock; Richard N Upton
The difficult airway: propofol infusion as an alternative to gaseous induction.
Anaesthesia and intensive care 1997;25(1):71-3.
1996: Richard N Upton
A model of the first pass passage of drugs from i.v. injection site to the heart--parameter estimates for lignocaine in the sheep.
British journal of anaesthesia 1996;77(6):764-72.
1996: Laurence E Mather; Richard N Upton; J L Huang; Guy L Ludbrook; E Gray; C Grant
The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis.
The Journal of pharmacology and experimental therapeutics 1996;279(1):291-7.
1996: Richard N Upton
Relationships between blood drug concentrations and cerebral effects.
Clinical and experimental pharmacology & physiology 1996;23(8):S52-3.
1996: Richard N Upton; Yi Fei Huang; Cliff Grant; E C Gray; Guy L Ludbrook
Myocardial pharmacokinetics of thiopental in sheep after short-term administration: relationship to thiopental-induced reductions in myocardial contractility.
Journal of pharmaceutical sciences 1996;85(8):863-7.
1996: Guy L Ludbrook; Richard N Upton; Cliff Grant; E C Gray
Brain and blood concentrations of propofol after rapid intravenous injection in sheep, and their relationships to cerebral effects.
Anaesthesia and intensive care 1996;24(4):445-52.
1996: Yi Fei Huang; Richard N Upton; A J Rutten
Adverse haemodynamic effects of the rapid intravenous injection of hypotonic solutions in sheep.
Research in veterinary science 1996;60(3):209-12.
1996: Richard N Upton; Guy L Ludbrook; Cliff Grant; E C Gray
In vivo relationships between the cerebral pharmacokinetics and pharmacodynamics of thiopentone in sheep after short-term administration.
Journal of pharmacokinetics and biopharmaceutics 1996;24(1):1-18.
1996: Guy L Ludbrook; Richard N Upton; Cliff Grant; E C Gray
Cerebral effects of propofol following bolus administration in sheep.
Anaesthesia and intensive care 1996;24(1):26-31.
1994: Yi Fei Huang; Richard N Upton; L E Mather
The pharmacokinetics of meperidine in the myocardium of conscious sheep.
Anesthesia and analgesia 1994;79(5):987-92.
1994: Richard N Upton
An analysis of errors arising from the direct use of mass balance principles to describe regional drug uptake and elution.
Journal of pharmacokinetics and biopharmaceutics 1994;22(4):309-21.
1994: Yi Fei Huang; Richard N Upton; A J Rutten; L E Mather
The hemodynamic effects of intravenous bolus doses of meperidine in conscious sheep.
Anesthesia and analgesia 1994;78(3):442-9.
1993: Yi Fei Huang; Richard N Upton
An estimate of the rate of direct drug diffusion from the surface of heart and kidney--implications for their representation as compartments.
Biopharmaceutics & drug disposition 1993;14(8):647-58.
1993: Yi Fei Huang; Richard N Upton; William B Runciman
IV bolus administration of subconvulsive doses of lignocaine to conscious sheep: relationships between myocardial pharmacokinetics and pharmacodynamics.
British journal of anaesthesia 1993;70(5):556-61.
1993: Richard N Upton; Yi Fei Huang
Influence of cardiac output, injection time and injection volume on the initial mixing of drugs with venous blood after i.v. bolus administration to sheep.
British journal of anaesthesia 1993;70(3):333-8.
1993: Yi Fei Huang; Richard N Upton; William B Runciman
IV bolus administration of subconvulsive doses of lignocaine to conscious sheep: myocardial pharmacokinetics.
British journal of anaesthesia 1993;70(3):326-32.
1992: Yi Fei Huang; Richard N Upton; A J Rutten; William B Runciman
IV bolus administration of subconvulsive doses of lignocaine to conscious sheep: effects on circulatory function.
British journal of anaesthesia 1992;69(4):368-74.
1991: Yi Fei Huang; Richard N Upton; L E Mather; William B Runciman
An assessment of methods for sampling blood to characterize rapidly changing blood drug concentrations.
Journal of pharmaceutical sciences 1991;80(9):847-51.
1991: Richard N Upton; L E Mather; William B Runciman; C F McLean; R J Carapetis
Uptake and elution of chlormethiazole, meperidine, and minaxolone in the hindquarters of sheep: implications for clearance calculations.
Journal of pharmaceutical sciences 1991;80(2):108-12.
1991: Richard N Upton; William B Runciman; L E Mather
Regional pharmacokinetics. III. Modelling methods.
Biopharmaceutics & drug disposition 1991;12(1):1-15.
1991: Richard N Upton; C Nancarrow; C F McLean; L E Mather; William B Runciman
The in vivo blood, fat and muscle concentrations of lignocaine and bupivacaine in the hindquarters of sheep.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(1):13-22.
1991: Richard N Upton; L E Mather; William B Runciman
The in vitro uptake and metabolism of lignocaine, procainamide and pethidine by tissues of the hindquarters of sheep.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(1):1-12.
1991: Yi Fei Huang; Richard N Upton; William B Runciman; L E Mather
Insight into interstitial drug disposition: lymph concentrations of lidocaine, procainamide and meperidine in the hindquarters of unanesthetized and anesthetized sheep.
The Journal of pharmacology and experimental therapeutics 1991;256(1):69-75.
1990: Richard N Upton; William B Runciman; L E Mather
Regional pharmacokinetics. II. Experimental methods.
Biopharmaceutics & drug disposition 1990;11(9):741-52.
1990: Richard N Upton
Regional pharmacokinetics. I. Physiological and physicochemical basis.
Biopharmaceutics & drug disposition 1990;11(8):647-62.
1989: A J Rutten; C Nancarrow; L E Mather; AH Ilsley; William B Runciman; Richard N Upton
Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep.
Anesthesia and analgesia 1989;69(3):291-9.
1988: Richard N Upton; William B Runciman; L E Mather; C F McLean; AH Ilsley
The uptake and elution of lignocaine and procainamide in the hindquarters of the sheep described using mass balance principles.
Journal of pharmacokinetics and biopharmaceutics 1988;16(1):31-40.
1988: Richard N Upton; L E Mather; William B Runciman; C Nancarrow; R J Carapetis
The use of mass balance principles to describe regional drug distribution and elimination.
Journal of pharmacokinetics and biopharmaceutics 1988;16(1):13-29.
1987: C Nancarrow; William B Runciman; L E Mather; Richard N Upton; J L Plummer
The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep.
Anesthesia and analgesia 1987;66(10):925-35.
1986: William B Runciman; L E Mather; AH Ilsley; R J Carapetis; Richard N Upton
A sheep preparation for studying interactions between blood flow and drug disposition. VI: Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition.
British journal of anaesthesia 1986;58(11):1308-16.
1986: L E Mather; William B Runciman; R J Carapetis; AH Ilsley; Richard N Upton
Hepatic and renal clearances of lidocaine in conscious and anesthetized sheep.
Anesthesia and analgesia 1986;65(9):943-9.
1986: L E Mather; William B Runciman; AH Ilsley; R J Carapetis; Richard N Upton
A sheep preparation for studying interactions between blood flow and drug disposition. V: The effects of general and subarachnoid anaesthesia on blood flow and pethidine disposition.
British journal of anaesthesia 1986;58(8):888-96.
1985: William B Runciman; L E Mather; AH Ilsley; R J Carapetis; Richard N Upton
A sheep preparation for studying interactions between blood flow and drug disposition. IV: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition.
British journal of anaesthesia 1985;57(12):1239-47.
1984: William B Runciman; L E Mather; AH Ilsley; R J Carapetis; Richard N Upton
A sheep preparation for studying interactions between blood flow and drug disposition. III: Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions.
British journal of anaesthesia 1984;56(11):1247-58.