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Jeremy Nathans

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TOP 3
Hao Chang; Jeremy Nathans
Responses of hair follicle-associated structures to loss of planar cell polarity signaling.
Lisa Huang; Han Liu; Amir Rattner; Jeremy Nathans
How to draw the line in biomedical research.
Yanshu Wang; John Williams; Yulian Zhou; Amir Rattner; Philip M Smallwood; Jeremy Nathans
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.

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All Publications

2013: Hao Chang; Jeremy Nathans
Responses of hair follicle-associated structures to loss of planar cell polarity signaling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(10):E908-17.
2013: Lisa Huang; Han Liu; Amir Rattner; Jeremy Nathans
How to draw the line in biomedical research.
eLife 2013;2():e00638.
2012: Yanshu Wang; John Williams; Yulian Zhou; Amir Rattner; Philip M Smallwood; Jeremy Nathans
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
Cell 2012;151(6):1332-44.
2012: Huimin Yu; Xin Ye; Nini Guo; Jeremy Nathans
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.
Development (Cambridge, England) 2012;139(23):4383-94.
2012: Tudor Constantin Badea; Oluwaseyi Motajo; Melody Shi; Philip M Smallwood; John Williams; Jeremy Nathans
Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(3):995-1007.
2012: Hao Wu; John Williams; Jeremy Nathans
Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling.
eLife 2012;1():e00181.
2012: David Julius; Jeremy Nathans
Signaling by sensory receptors.
Cold Spring Harbor perspectives in biology 2012;4(1):a005991.
2011: Hugh Cahill; Amir Rattner; Jeremy Nathans
Preclinical assessment of CNS drug action using eye movements in mice.
The Journal of clinical investigation 2011;121(9):3528-41.
2011: Ryota L Matsuoka; Jeremy Nathans; Neal S Peachey; Ivy S Samuels; Fumikazu Suto; Yutaka Yoshida; Tudor Constantin Badea; Hugh Cahill; Alain Chédotal; Onanong Chivatakarn; Roman J Giger; Kei-Ichi Katayama; Sumit R Kumar; Alex L Kolodkin
Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.
Neuron 2011;71(3):460-73.
2011: Xin Ye; Yanshu Wang; Amir Rattner; Jeremy Nathans
Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.
Development (Cambridge, England) 2011;138(6):1161-72.
2011: Tudor Constantin Badea; Jeremy Nathans
Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.
Vision research 2011;51(2):269-79.
2011: Xin Ye; Philip M Smallwood; Jeremy Nathans
Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain.
Gene expression patterns : GEP 2011;11(1-2):151-5.
2011: Nelson Chuang; Susumu Mori; Akira Yamamoto; Hangyi Jiang; Xin Ye; Xin Xu; Linda J Richards; Jeremy Nathans; Michael I Miller; Arthur W Toga; Richard L Sidman; Jiangyang Zhang
An MRI-based atlas and database of the developing mouse brain.
NeuroImage 2011;54(1):80-9.
2010: Jeremy Nathans
China's plan flawed but courageous.
Science (New York, N.Y.) 2010;330(6011):1625.
2010: Yanshu Wang; Hao Chang; Jeremy Nathans
When whorls collide: the development of hair patterns in frizzled 6 mutant mice.
Development (Cambridge, England) 2010;137(23):4091-9.
2010: Huimin Yu; Philip M Smallwood; Yanshu Wang; Roman Vidaltamayo; Randall R Reed; Jeremy Nathans
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Development (Cambridge, England) 2010;137(21):3707-17.
2010: Xin Ye; Yanshu Wang; Jeremy Nathans
The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease.
Trends in molecular medicine 2010;16(9):417-25.
2010: P H Gleick; R M Adams; R M Amasino; E Anders; D J Anderson; W W Anderson; L E Anselin; M K Arroyo; B Asfaw; F J Ayala; A Bax; A J Bebbington; G Bell; M V L Bennett; Jeffrey L Bennetzen; M R Berenbaum; O B Berlin; P J Bjorkman; E Blackburn; J E Blamont; M R Botchan; J S Boyer; E A Boyle; D Branton; S P Briggs; W R Briggs; W J Brill; R J Britten; W S Broecker; J H Brown; P O Brown; A T Brunger; J Cairns; D E Canfield; S R Carpenter; J C Carrington; A R Cashmore; J C Castilla; A Cazenave; F S Chapin; A J Ciechanover; D E Clapham; W C Clark; R N Clayton; M D Coe; E M Conwell; E B Cowling; R M Cowling; C S Cox; R B Croteau; D M Crothers; P J Crutzen; G C Daily; G B Dalrymple; J L Dangl; S A Darst; D R Davies; M B Davis; Pietro De Camilli; C Dean; R S DeFries; J Deisenhofer; D P Delmer; E F DeLong; D J DeRosier; T O Diener; R Dirzo; J E Dixon; M J Donoghue; R F Doolittle; T Dunne; P R Ehrlich; S N Eisenstadt; T Eisner; K A Emanuel; S W Englander; W G Ernst; P G Falkowski; G Feher; J A Ferejohn; A Fersht; E H Fischer; R Fischer; K V Flannery; J Frank; P A Frey; I Fridovich; C Frieden; D J Futuyma; W R Gardner; C J R Garrett; W Gilbert; R B Goldberg; W H Goodenough; C S Goodman; M Goodman; Paul Greengard; S Hake; G Hammel; S Hanson; S C Harrison; S R Hart; D L Hartl; R Haselkorn; K Hawkes; J M Hayes; B Hille; T Hökfelt; J S House; M Hout; D M Hunten; I A Izquierdo; A T Jagendorf; D H Janzen; R Jeanloz; C S Jencks; W A Jury; H R Kaback; T Kailath; P Kay; S A Kay; D Kennedy; A Kerr; R C Kessler; G S Khush; S W Kieffer; P V Kirch; K Kirk; M G Kivelson; J P Klinman; A Klug; L Knopoff; H Kornberg; J E Kutzbach; J C Lagarias; K Lambeck; A Landy; C H Langmuir; B A Larkins; X T Le Pichon; R E Lenski; E B Leopold; S A Levin; M Levitt; G E Likens; J Lippincott-Schwartz; L Lorand; C O Lovejoy; M Lynch; A L Mabogunje; T F Malone; S Manabe; J Marcus; D S Massey; J C McWilliams; E Medina; H J Melosh; D J Meltzer; C D Michener; E L Miles; H A Mooney; P B Moore; F M M Morel; E S Mosley-Thompson; B Moss; W H Munk; N Myers; G B Nair; Jeremy Nathans; E W Nester; R A Nicoll; R P Novick; J F O'Connell; P E Olsen; N D Opdyke; G F Oster; E Ostrom; N R Pace; R T Paine; R D Palmiter; J Pedlosky; G A Petsko; G H Pettengill; S G Philander; D R Piperno; T D Pollard; P B Price; P A Reichard; B F Reskin; R E Ricklefs; R L Rivest; J D Roberts; A K Romney; M G Rossmann; D W Russell; W J Rutter; J A Sabloff; R Z Sagdeev; M D Sahlins; A Salmond; Joshua R Sanes; R Schekman; J Schellnhuber; D W Schindler; J Schmitt; S H Schneider; Vern L Schramm; R R Sederoff; C J Shatz; F Sherman; R L Sidman; K Sieh; E L Simons; B H Singer; M F Singer; B Skyrms; N H Sleep; B D Smith; S H Snyder; R R Sokal; C S Spencer; T A Steitz; K B Strier; T C Südhof; S S Taylor; J Terborgh; D H Thomas; L G Thompson; R T Tjian; M G Turner; S Uyeda; J W Valentine; J S Valentine; J L Van Etten; K E van Holde; M Vaughan; S Verba; P H von Hippel; D B Wake; A Walker; J E Walker; E B Watson; P J Watson; D Weigel; S R Wessler; M J West-Eberhard; T D White; W J Wilson; R V Wolfenden; J A Wood; G M Woodwell; H E Wright; C Wu; C Wunsch; M L Zoback
Climate change and the integrity of science.
Science (New York, N.Y.) 2010;328(5979):689-90.
2009: Xin Ye; Yanshu Wang; Hugh Cahill; Minzhong Yu; Tudor C Badea; Philip M Smallwood; Neal S Peachey; Jeremy Nathans
Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.
Cell 2009;139(2):285-98.
2009: Gerald H Jacobs; Jeremy Nathans
The evolution of Primate color vision.
Scientific American 2009;300(4):56-63.
2009: Tudor C Badea; Hugh Cahill; Jen Ecker; Samer Hattar; Jeremy Nathans
Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.
Neuron 2009;61(6):852-64.
2009: Tudor Constantin Badea; Zhong L Hua; Philip M Smallwood; John Williams; Thomas Rotolo; Xin Ye; Jeremy Nathans
New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling.
PloS one 2009;4(11):e7859.
2008: Chunqiao Liu; Jeremy Nathans
An essential role for frizzled 5 in mammalian ocular development.
Development (Cambridge, England) 2008;135(21):3567-76.
2008: Amir Rattner; Leila Toulabi; John Williams; Huimin Yu; Jeremy Nathans
The genomic response of the retinal pigment epithelium to light damage and retinal detachment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9880-9.
2008: Chunqiao Liu; Yanshu Wang; Philip M Smallwood; Jeremy Nathans
An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(22):5641-53.
2008: Thomas Rotolo; Philip M Smallwood; John Williams; Jeremy Nathans
Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology.
PloS one 2008;3(12):e4099.
2008: Hugh Cahill; Jeremy Nathans
The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation.
PloS one 2008;3(4):e2055.
2007: Jichao Chen; Jeremy Nathans
Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis.
Developmental cell 2007;13(3):325-37.
2007: Jichao Chen; Jeremy Nathans
Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse.
Investigative ophthalmology & visual science 2007;48(6):2799-805.
2007: Gerald H Jacobs; Gary A Williams; Hugh Cahill; Jeremy Nathans
Emergence of novel color vision in mice engineered to express a human cone photopigment.
Science (New York, N.Y.) 2007;315(5819):1723-5.
2007: Philip M Smallwood; John Williams; Qiang Xu; Daniel J Leahy; Jeremy Nathans
Mutational analysis of Norrin-Frizzled4 recognition.
The Journal of biological chemistry 2007;282(6):4057-68.
2007: Yanshu Wang; Jeremy Nathans
Tissue/planar cell polarity in vertebrates: new insights and new questions.
Development (Cambridge, England) 2007;134(4):647-58.
2006: Yanshu Wang; Tudor Constantin Badea; Jeremy Nathans
Order from disorder: Self-organization in mammalian hair patterning.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19800-5.
2006: Amir Rattner; Jeremy Nathans
Macular degeneration: recent advances and therapeutic opportunities.
Nature reviews. Neuroscience 2006;7(11):860-72.
2006: Jichao Chen; Amir Rattner; Jeremy Nathans
Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements.
Human molecular genetics 2006;15(13):2146-56.
2006: Takashi Tsunenari; Jeremy Nathans; King-Wai Yau
Ca2+-activated Cl- current from human bestrophin-4 in excised membrane patches.
The Journal of general physiology 2006;127(6):749-54.
2006: Amir Rattner; Jeremy Nathans
An evolutionary perspective on the photoreceptor damage response.
American journal of ophthalmology 2006;141(3):558-562.
2006: Yanshu Wang; Nini Guo; Jeremy Nathans
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(8):2147-56.
2006: Yanshu Wang; Jiangyang Zhang; Susumu Mori; Jeremy Nathans
Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):355-64.
2005: Jeremy Nathans
Written in our genes?
Science (New York, N.Y.) 2005;308(5729):1742.
2005: Amir Rattner; Jeremy Nathans
The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(18):4540-9.
2005: Jichao Chen; Amir Rattner; Jeremy Nathans
The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(1):118-29.
2004: Tudor Constantin Badea; Jeremy Nathans
Quantitative analysis of neuronal morphologies in the mouse retina visualized by using a genetically directed reporter.
The Journal of comparative neurology 2004;480(4):331-51.
2004: Amir Rattner; Jichao Chen; Jeremy Nathans
Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly.
The Journal of biological chemistry 2004;279(40):42202-10.
2004: Nini Guo; Charles Hawkins; Jeremy Nathans
Frizzled6 controls hair patterning in mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9277-81.
2004: Wenqin Luo; John Williams; Philip M Smallwood; Jeffrey W Touchman; Laura M Roman; Jeremy Nathans
Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish.
The Journal of biological chemistry 2004;279(18):19286-93.
2004: Qiang Xu; Yanshu Wang; Alain Dabdoub; Philip M Smallwood; John Williams; Chad Woods; Matthew W Kelley; Li Jiang; William Tasman; Kang Zhang; Jeremy Nathans
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.
Cell 2004;116(6):883-95.
2004: Wenqin Luo; Nicholas Marsh-Armstrong; Amir Rattner; Jeremy Nathans
An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(11):2623-32.
2003: Anna I Lyuksyutova; Chin-Chun Lu; Nancy Milanesio; Leslie A King; Nini Guo; Yanshu Wang; Jeremy Nathans; Marc Tessier-Lavigne; Yimin Zou
Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling.
Science (New York, N.Y.) 2003;302(5652):1984-8.
2003: Takashi Tsunenari; Hui Sun; John Williams; Hugh Cahill; Philip M Smallwood; King-Wai Yau; Jeremy Nathans
Structure-function analysis of the bestrophin family of anion channels.
The Journal of biological chemistry 2003;278(42):41114-25.
2003: Vaishali Parikh; Yin Yao Shugart; Kimberly F Doheny; JIE ZHANG; Lan Li; John Williams; David Hayden; Brian Craig; Hilda Capo; Denise Chamblee; Cathy Chen; MARY COLLINS; Stuart Dankner; Dean Fiergang; David L Guyton; David Hunter; Marcia Hutcheon; Marshall Keys; Nancy Morrison; Michelle Munoz; Marshall Parks; David Plotsky; Eugene Protzko; Michael X Repka; Maria Sarubbi; Bruce Schnall; R Michael Siatkowski; Elias Traboulsi; Joanne M Waeltermann; Jeremy Nathans
A strabismus susceptibility locus on chromosome 7p.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12283-8.
2003: Philip M Smallwood; Bence P Olveczky; Gary L Williams; Gerald H Jacobs; Benjamin E Reese; Markus Meister; Jeremy Nathans
Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11706-11.
2003: Tudor Constantin Badea; Yanshu Wang; Jeremy Nathans
A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2314-22.
2002: Yanshu Wang; Nupur Thekdi; Philip M Smallwood; Jennifer P Macke; Jeremy Nathans
Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(19):8563-73.
2002: Hui Sun; Takashi Tsunenari; King-Wai Yau; Jeremy Nathans
The vitelliform macular dystrophy protein defines a new family of chloride channels.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):4008-13.
2002: Philip M Smallwood; Yanshu Wang; Jeremy Nathans
Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):1008-11.
2001: Amir Rattner; Philip M Smallwood; J Williams; C Cooke; A Savchenko; Arkady L Lyubarsky; Edward N Pugh; Jeremy Nathans
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival.
Neuron 2001;32(5):775-86.
2001: Hui Sun; Jeremy Nathans
Mechanistic studies of ABCR, the ABC transporter in photoreceptor outer segments responsible for autosomal recessive Stargardt disease.
Journal of bioenergetics and biomembranes 2001;33(6):523-30.
2001: Pradeep Y Ramulu; M Kennedy; Wei-Hong Xiong; John Williams; Mitra Cowan; D Blesh; King-Wai Yau; J B Hurley; Jeremy Nathans
Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).
Molecular and cellular biology 2001;21(24):8605-14.
2001: H Sun; Jeremy Nathans
The challenge of macular degeneration.
Scientific American 2001;285(4):68-75.
2001: Marcia J Simovich; B Miller; Hany Ezzeldin; B T Kirkland; G McLeod; C Fulmer; Jeremy Nathans; S G Jacobson; Steven J Pittler
Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis.
Human mutation 2001;18(2):164.
2001: Pradeep Y Ramulu; Jeremy Nathans
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
The Journal of biological chemistry 2001;276(27):25127-35.
2001: Charles E Dann; JC Hsieh; Amir Rattner; D Sharma; Jeremy Nathans; Daniel J Leahy
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Nature 2001;412(6842):86-90.
2001: Yanshu Wang; David L Huso; Hugh Cahill; David Ryugo; Jeremy Nathans
Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4761-71.
2001: Hui Sun; Jeremy Nathans
ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro. Implications for retinal disease.
The Journal of biological chemistry 2001;276(15):11766-74.
2001: I Muñoz-Sanjuán; Michael K Cooper; Philip A Beachy; John Fallon; Jeremy Nathans
Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;220(3):238-45.
2000: Hui Sun; Philip M Smallwood; Jeremy Nathans
Biochemical defects in ABCR protein variants associated with human retinopathies.
Nature genetics 2000;26(2):242-6.
2000: I Muñoz-Sanjuán; John Fallon; Jeremy Nathans
Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 at the base of the developing limbs.
Mechanisms of development 2000;95(1-2):101-12.
2000: Amir Rattner; Philip M Smallwood; Jeremy Nathans
Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol.
The Journal of biological chemistry 2000;275(15):11034-43.
2000: I Munoz-Sanjuan; Philip M Smallwood; Jeremy Nathans
Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing.
The Journal of biological chemistry 2000;275(4):2589-97.
2000: Andrew Stockman; Lindsay T Sharpe; Shannath L Merbs; Jeremy Nathans
Spectral sensitivities of human cone visual pigments determined in vivo and in vitro.
Methods in enzymology 2000;316():626-50.
2000: Hui Sun; Jeremy Nathans
ABCR: rod photoreceptor-specific ABC transporter responsible for Stargardt disease.
Methods in enzymology 2000;315():879-97.
1999: Donald J Zack; M Dean; Robert S Molday; Jeremy Nathans; T M Redmond; E M Stone; Anand Swaroop; David Valle; B H Weber
What can we learn about age-related macular degeneration from other retinal diseases?
Molecular vision 1999;5():30.
1999: Lindsay T Sharpe; Andrew Stockman; Herbert Jägle; H Knau; Jeremy Nathans
L, M and L-M hybrid cone photopigments in man: deriving lambda max from flicker photometric spectral sensitivities.
Vision research 1999;39(21):3513-25.
1999: Jeremy Nathans
The evolution and physiology of human color vision: insights from molecular genetic studies of visual pigments.
Neuron 1999;24(2):299-312.
1999: P Bhanot; Matthew Fish; J A Jemison; Roel Nusse; Jeremy Nathans; Ken M Cadigan
Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development.
Development (Cambridge, England) 1999;126(18):4175-86.
1999: Yanshu Wang; Philip M Smallwood; Mitra Cowan; D Blesh; Ann M Lawler; Jeremy Nathans
Mutually exclusive expression of human red and green visual pigment-reporter transgenes occurs at high frequency in murine cone photoreceptors.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5251-6.
1999: JC Hsieh; Laurent Kodjabachian; Martha L Rebbert; Amir Rattner; Philip M Smallwood; CH Samos; Roel Nusse; Igor B Dawid; Jeremy Nathans
A new secreted protein that binds to Wnt proteins and inhibits their activities.
Nature 1999;398(6726):431-6.
1999: JC Hsieh; Amir Rattner; Philip M Smallwood; Jeremy Nathans
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3546-51.
1999: Hui Sun; Robert S Molday; Jeremy Nathans
Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease.
The Journal of biological chemistry 1999;274(12):8269-81.
1999: Amir Rattner; H Sun; Jeremy Nathans
Molecular genetics of human retinal disease.
Annual review of genetics 1999;33():89-131.
1999: I Munoz-Sanjuan; BK Simandl; John Fallon; Jeremy Nathans
Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development.
Development (Cambridge, England) 1999;126(2):409-21.
1998: Lindsay T Sharpe; Andrew Stockman; Herbert Jägle; H Knau; G Klausen; A Reitner; Jeremy Nathans
Red, green, and red-green hybrid pigments in the human retina: correlations between deduced protein sequences and psychophysically measured spectral sensitivities.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):10053-69.
1998: E Soucy; Y Wang; S Nirenberg; Jeremy Nathans; Markus Meister
A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina.
Neuron 1998;21(3):481-93.
1998: Rando Allikmets; W W Wasserman; A Hutchinson; Philip M Smallwood; Jeremy Nathans; PK Rogan; TD Schneider; M Dean
Organization of the ABCR gene: analysis of promoter and splice junction sequences.
Gene 1998;215(1):111-22.
1997: P M Sherman; Hui Sun; Jennifer P Macke; John Williams; Philip M Smallwood; Jeremy Nathans
Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11639-44.
1997: Hui Sun; DJ Gilbert; Neal G Copeland; Nancy A Jenkins; Jeremy Nathans
Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9893-8.
1997: H Sun; Jeremy Nathans
Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments.
Nature genetics 1997;17(1):15-6.
1997: Mengqing Xiang; L Gan; D Li; Z Y Chen; L Zhou; Bert W O'Malley; W Klein; Jeremy Nathans
Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9445-50.
1997: Hui Sun; Jennifer P Macke; Jeremy Nathans
Mechanisms of spectral tuning in the mouse green cone pigment.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8860-5.
1997: Jennifer P Macke; Jeremy Nathans
Individual variation in size of the human red and green visual pigment gene array.
Investigative ophthalmology & visual science 1997;38(5):1040-3.
1997: Amir Rattner; JC Hsieh; Philip M Smallwood; DJ Gilbert; Neal G Copeland; Nancy A Jenkins; Jeremy Nathans
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2859-63.
1997: X He; J P Saint-Jeannet; Y Wang; Jeremy Nathans; Igor B Dawid; Harold Varmus
A member of the Frizzled protein family mediating axis induction by Wnt-5A.
Science (New York, N.Y.) 1997;275(5306):1652-4.
1997: Rando Allikmets; N Singh; H Sun; Noah Shroyer; A Hutchinson; A Chidambaram; B Gerrard; Lisa Baird; D Stauffer; Andy P Peiffer; Amir Rattner; Philip M Smallwood; Y Li; K L Anderson; R A Lewis; Jeremy Nathans; Mark Leppert; M Dean; James R Lupski
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy.
Nature genetics 1997;15(3):236-46.
1997: Mengqing Xiang; L Gan; D Li; L Zhou; Z Y Chen; D Wagner; Bert W O'Malley; W Klein; Jeremy Nathans
Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems.
Cold Spring Harbor symposia on quantitative biology 1997;62():325-36.
1996: Mengqing Xiang; Lin Gan; L Zhou; William H Klein; Jeremy Nathans
Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11950-5.
1996: Philip M Smallwood; I Munoz-Sanjuan; P Tong; Jennifer P Macke; STEWART HENDRY; D J Gilbert; Neal G Copeland; Nancy A Jenkins; Jeremy Nathans
Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9850-7.
1996: Mengqing Xiang; L Zhou; Jeremy Nathans
Similarities and differences among inner retinal neurons revealed by the expression of reporter transgenes controlled by Brn-3a, Brn-3b, and Brn-3c promotor sequences.
Visual neuroscience 1996;13(5):955-62.
1996: P Bhanot; M Brink; CH Samos; JC Hsieh; Y Wang; Jennifer P Macke; Deborah J Andrew; Jeremy Nathans; Roel Nusse
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Nature 1996;382(6588):225-30.
1996: Russell L Margolis; O Colin Stine; Melvin G McInnis; NG Ranen; David C Rubinsztein; J Leggo; LORRAINE BRANDO; A S Kidwai; S J Loev; TS Breschel; Colleen Callahan; Sylvia G Simpson; J. Raymond DePaulo; Francis McMajon; S Jain; Eugene S Paykel; C Walsh; Lynn E DeLisi; T J Crow; E F Torrey; R G Ashworth; Jennifer P Macke; Jeremy Nathans; Christopher A Ross
cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat.
Human molecular genetics 1996;5(5):607-16.
1996: Lin Gan; Mengqing Xiang; L Zhou; D S Wagner; William H Klein; Jeremy Nathans
POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):3920-5.
1996: H Zhou; T Yoshioka; Jeremy Nathans
Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(7):2261-74.
1996: Y Wang; Jennifer P Macke; B S Abella; Katrin Andreasson; Paul F Worley; D J Gilbert; Neal G Copeland; Nancy A Jenkins; Jeremy Nathans
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
The Journal of biological chemistry 1996;271(8):4468-76.
1996: Mengqing Xiang; H Zhou; Jeremy Nathans
Molecular biology of retinal ganglion cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):596-601.
1995: Mengqing Xiang; L Zhou; Jennifer P Macke; T Yoshioka; STEWART HENDRY; R L Eddy; T B Shows; Jeremy Nathans
The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(7 Pt 1):4762-85.
1995: Jennifer P Macke; J C Hennessey; Jeremy Nathans
Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347.
Human molecular genetics 1995;4(4):775-6.
1994: C H Sung; C Makino; D Baylor; Jeremy Nathans
A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(10):5818-33.
1994: Jeremy Nathans
In the eye of the beholder: visual pigments and inherited variation in human vision.
Cell 1994;78(3):357-60.
1994: D J Rosas; A J Roman; P Weissbrod; Jennifer P Macke; Jeremy Nathans
Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study.
Investigative ophthalmology & visual science 1994;35(8):3134-44.
1994: M I Chiu; Jeremy Nathans
A sequence upstream of the mouse blue visual pigment gene directs blue cone-specific transgene expression in mouse retinas.
Visual neuroscience 1994;11(4):773-80.
1994: M I Chiu; Jeremy Nathans
Blue cones and cone bipolar cells share transcriptional specificity as determined by expression of human blue visual pigment-derived transgenes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(6):3426-36.
1994: Jimo Borjigin; Jeremy Nathans
Insertional mutagenesis as a probe of rhodopsin's topography, stability, and activity.
The Journal of biological chemistry 1994;269(20):14715-22.
1994: M I Chiu; Donald J Zack; Y Wang; Jeremy Nathans
Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.
Genomics 1994;21(2):440-3.
1994: Samuel G Jacobson; C M Kemp; Artur Vahe Cideciyan; Jennifer P Macke; C H Sung; Jeremy Nathans
Phenotypes of stop codon and splice site rhodopsin mutations causing retinitis pigmentosa.
Investigative ophthalmology & visual science 1994;35(5):2521-34.
1994: C Portera-Cailliau; C H Sung; Jeremy Nathans; Ruben Adler
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):974-8.
1993: C J Weitz; Jeremy Nathans
Rhodopsin activation: effects on the metarhodopsin I-metarhodopsin II equilibrium of neutralization or introduction of charged amino acids within putative transmembrane segments.
Biochemistry 1993;32(51):14176-82.
1993: C H Sung; C M Davenport; Jeremy Nathans
Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain.
The Journal of biological chemistry 1993;268(35):26645-9.
1993: Shannath L Merbs; Jeremy Nathans
Role of hydroxyl-bearing amino acids in differentially tuning the absorption spectra of the human red and green cone pigments.
Photochemistry and photobiology 1993;58(5):706-10.
1993: Jeremy Nathans; Irene H Maumenee; E Zrenner; B Sadowski; L T Sharpe; R A Lewis; E Hansen; T Rosenberg; M Schwartz; John R Heckenlively
Genetic heterogeneity among blue-cone monochromats.
American journal of human genetics 1993;53(5):987-1000.
1993: Jennifer P Macke; N Hu; S Hu; M Bailey; V L King; Terry R Brown; D Hamer; Jeremy Nathans
Sequence variation in the androgen receptor gene is not a common determinant of male sexual orientation.
American journal of human genetics 1993;53(4):844-52.
1993: Mengqing Xiang; L Zhou; Y W Peng; R L Eddy; T B Shows; Jeremy Nathans
Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.
Neuron 1993;11(4):689-701.
1993: R L Johnson; Kathryn B Grant; T C Zankel; M F Boehm; Shannath L Merbs; Jeremy Nathans; K Nakanishi
Cloning and expression of goldfish opsin sequences.
Biochemistry 1993;32(1):208-14.
1993: Jimo Borjigin; Jeremy Nathans
Bovine pancreatic trypsin inhibitor-trypsin complex as a detection system for recombinant proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):337-41.
1992: Shannath L Merbs; Jeremy Nathans
Photobleaching difference absorption spectra of human cone pigments: quantitative analysis and comparison to other methods.
Photochemistry and photobiology 1992;56(6):869-81.
1992: Shannath L Merbs; Jeremy Nathans
Absorption spectra of the hybrid pigments responsible for anomalous color vision.
Science (New York, N.Y.) 1992;258(5081):464-6.
1992: Y Wang; Jennifer P Macke; Shannath L Merbs; Donald J Zack; B Klaunberg; J Bennett; John D Gearhart; Jeremy Nathans
A locus control region adjacent to the human red and green visual pigment genes.
Neuron 1992;9(3):429-40.
1992: C J Weitz; L N Went; Jeremy Nathans
Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment.
American journal of human genetics 1992;51(2):444-6.
1992: R S Dhallan; Jennifer P Macke; R L Eddy; T B Shows; Randall R Reed; King-Wai Yau; Jeremy Nathans
Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(8):3248-56.
1992: Jeremy Nathans
Rhodopsin: structure, function, and genetics.
Biochemistry 1992;31(21):4923-31.
1992: S Z Wang; Ruben Adler; Jeremy Nathans
A visual pigment from chicken that resembles rhodopsin: amino acid sequence, gene structure, and functional expression.
Biochemistry 1992;31(13):3309-15.
1992: Shannath L Merbs; Jeremy Nathans
Absorption spectra of human cone pigments.
Nature 1992;356(6368):433-5.
1992: C J Weitz; Jeremy Nathans
Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II.
Neuron 1992;8(3):465-72.
1992: C J Weitz; Y Miyake; K Shinzato; E Montag; E Zrenner; L N Went; Jeremy Nathans
Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.
American journal of human genetics 1992;50(3):498-507.
1992: C M Kemp; Samuel G Jacobson; A J Roman; C H Sung; Jeremy Nathans
Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation.
American journal of ophthalmology 1992;113(2):165-74.
1992: Jeremy Nathans; Shannath L Merbs; C H Sung; C J Weitz; Y Wang
Molecular genetics of human visual pigments.
Annual review of genetics 1992;26():403-24.
1992: Jeremy Nathans; C H Sung; C J Weitz; C M Davenport; Shannath L Merbs; Y Wang
Visual pigments and inherited variation in human vision.
Society of General Physiologists series 1992;47():109-31.
1991: C H Sung; B G Schneider; N Agarwal; D S Papermaster; Jeremy Nathans
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8840-4.
1991: Samuel G Jacobson; C M Kemp; C H Sung; Jeremy Nathans
Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations.
American journal of ophthalmology 1991;112(3):256-71.
1991: C H Sung; C M Davenport; J C Hennessey; Irene H Maumenee; Samuel G Jacobson; John R Heckenlively; R Nowakowski; Gerald A Fishman; Peter Gouras; Jeremy Nathans
Rhodopsin mutations in autosomal dominant retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6481-5.
1991: Donald J Zack; J Bennett; Y Wang; C Davenport; B Klaunberg; John D Gearhart; Jeremy Nathans
Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas.
Neuron 1991;6(2):187-99.
1990: Jeremy Nathans
Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin.
Biochemistry 1990;29(41):9746-52.
1990: Jeremy Nathans
Determinants of visual pigment absorbance: role of charged amino acids in the putative transmembrane segments.
Biochemistry 1990;29(4):937-42.
1990: Jeremy Nathans
Protein-chromophore interactions in rhodopsin studied by site-directed mutagenesis.
Cold Spring Harbor symposia on quantitative biology 1990;55():621-33.
1989: Jeremy Nathans; C M Davenport; Irene H Maumenee; R A Lewis; J F Hejtmancik; M Litt; E Lovrien; Richard G Weleber; B Bachynski; Fred Zwas
Molecular genetics of human blue cone monochromacy.
Science (New York, N.Y.) 1989;245(4920):831-8.
1989: Jeremy Nathans
The genes for color vision.
Scientific American 1989;260(2):42-9.
1989: Jeremy Nathans; C J Weitz; N Agarwal; I Nir; D S Papermaster
Production of bovine rhodopsin by mammalian cell lines expressing cloned cDNA: spectrophotometry and subcellular localization.
Vision research 1989;29(8):907-14.
1988: Douglas Vollrath; Jeremy Nathans; Ronald W Davis
Tandem array of human visual pigment genes at Xq28.
Science (New York, N.Y.) 1988;240(4859):1669-72.
1987: Jeremy Nathans
Molecular biology of visual pigments.
Annual review of neuroscience 1987;10():163-94.
1986: Jeremy Nathans; Tom Piantanida; R L Eddy; T B Shows; D S Hogness
Molecular genetics of inherited variation in human color vision.
Science (New York, N.Y.) 1986;232(4747):203-10.
1986: Jeremy Nathans; D Thomas; D S Hogness
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.
Science (New York, N.Y.) 1986;232(4747):193-202.
1984: Jeremy Nathans; D S Hogness
Isolation and nucleotide sequence of the gene encoding human rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(15):4851-5.
1983: Jeremy Nathans; D S Hogness
Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin.
Cell 1983;34(3):807-14.
1979: H M Kronenberg; B E McDevitt; J A Majzoub; Jeremy Nathans; Phillip A Sharp; J T Potts; A Rich
Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):4981-5.
1978: A H Wang; Jeremy Nathans; G van der Marel; J H van Boom; A Rich
Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound.
Nature 1978;276(5687):471-4.