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Oliver Fackler

Research Profile

Chemicals & Drugs

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HIV-1

Physiology

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Sebastian Bolduan; Oliver T Fackler; Joëlle V Fritz; Kristin Höhne; Philipp Hubel; Frank Kirchhoff; Veronika Lodermeyer; Tatjana Reif; Daniel Sauter; Michael Schindler; Ulrich Schubert
HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.
André Schönichen; Unai Silván; Elmar Behrmann; Leif Dehmelt; Oliver T Fackler; Sonja Kühn; Hans Georg Mannherz; Antonina J Mazur; Stefan Raunser; Cora-Ann Schoenenberger; Matthias Geyer
FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers.
Daniel Sauter; Daniel Unterweger; Shariq M Usmani; Michael Vogl; Silvia F Kluge; Gerald Learn; Markus Moll; Martine Peeters; Edward Barker; Frederic Bibollet-Ruche; Oliver T Fackler; Joëlle V Fritz; Beatrice H Hahn; Anke Heigele; Elisabeth Hermkes; Frank Kirchhoff
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.

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All Publications

2013: Sebastian Bolduan; Oliver T Fackler; Joëlle V Fritz; Kristin Höhne; Philipp Hubel; Frank Kirchhoff; Veronika Lodermeyer; Tatjana Reif; Daniel Sauter; Michael Schindler; Ulrich Schubert
HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.
Virology 2013;440(2):190-203.
2013: André Schönichen; Unai Silván; Elmar Behrmann; Leif Dehmelt; Oliver T Fackler; Sonja Kühn; Hans Georg Mannherz; Antonina J Mazur; Stefan Raunser; Cora-Ann Schoenenberger; Matthias Geyer
FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers.
Journal of cell science 2013;126(Pt 8):1891-901.
2012: Daniel Sauter; Daniel Unterweger; Shariq M Usmani; Michael Vogl; Silvia F Kluge; Gerald Learn; Markus Moll; Martine Peeters; Edward Barker; Frederic Bibollet-Ruche; Oliver T Fackler; Joëlle V Fritz; Beatrice H Hahn; Anke Heigele; Elisabeth Hermkes; Frank Kirchhoff
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.
PLoS pathogens 2012;8(12):e1003093.
2012: Bettina Stolp; Fernanda Matos Coelho; Roser Gorina; Miroslav Hons; Andrea Imle; Ruth Lyck; Jens V Stein; Oliver T Fackler
HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18541-6.
2012: Hanna-Mari Baldauf; Manja Burggraf; Waaqo Daddacha; Elina Erikson; Oliver T Fackler; Egbert Flory; Thomas Gramberg; Baek Kim; Renate König; Nathaniel R Landau; Felix Lasitschka; Xiaoyu Pan; Sylvia Panitz; Frank Rutsch; Kristina Schenkova; Sarah Schmidt; Serkan Sertel; Guido Wabnitz; Ina Ambiel; Oliver T Keppler
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine 2012;18(11):1682-7.
2012: Nicola Götz; Beatrice H Hahn; Anke Heigele; Frederic Bibollet-Ruche; Oliver T Fackler; Joëlle V Fritz; Matthias Geyer; Christine Goffinet; Gerald Learn; Daniel Sauter; Shariq M Usmani; Frank Kirchhoff
Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host.
Cell host & microbe 2012;12(3):373-80.
2012: Libin Abraham; Peter Bankhead; Ulrike Engel; Xiaoyu Pan; Oliver T Fackler
HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1898-910.
2012: Jana Stastna; Haicui Wang; Robert Grosse; Alina Kollmannsperger; Stefan Kutscheidt; Volker Lohmann; xiaoyu pan; Oliver T Fackler
Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation.
Cell research 2012;22(4):728-45.
2012: Joëlle V Fritz; Oliver T Keppler; Nadine Tibroni; Oliver T Fackler
HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin.
Virology 2012;424(1):33-44.
2012: xiaoyu pan; Jochen M Rudolph; Libin Abraham; Anja Habermann; Claudia Haller; Jacomine Krijnse-Locker; Oliver T Fackler
HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling.
Blood 2012;119(3):786-97.
2012: Libin Abraham; Oliver T Fackler
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.
Cell communication and signaling : CCS 2012;10(1):39.
2012: Pieter J Meuwissen; Evelien Naessens; Kalle Saksela; Bettina Stolp; Guido Vanham; Kevin K Arien; Oliver T Fackler; Matthias Geyer; Veronica Iannucci; Jolien Vermeire; Bruno Verhasselt
Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.
Retrovirology 2012;9():34.
2011: Claudia Haller; Jochen M Rudolph; Nadine Tibroni; Robert Grosse; Oliver T Fackler
Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse.
European journal of cell biology 2011;90(11):913-21.
2011: Bettina Stolp; Oliver T Fackler
How HIV takes advantage of the cytoskeleton in entry and replication.
Viruses 2011;3(4):293-311.
2011: Jérôme Bouchet; Stéphane E Basmaciogullari; Pavel Chrobak; Bettina Stolp; Nathalie Bouchard; Oliver T Fackler; Patrick Chames; Paul Jolicoeur; Serge Benichou; Daniel Baty
Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.
Blood 2011;117(13):3559-68.
2011: Nopporn Chutiwitoonchai; Oliver T Fackler; Masateru Hiyoshi; Philip Mwimanzi; Hirotaka Ode; Seiji Okada; Hironori Sato; Akio Adachi; Takamasa Ueno; Shinya Suzu
The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.
PloS one 2011;6(11):e27696.
2011: Sebastian Breuer; Simone I Schievink; Antje Schulte; Wulf Blankenfeldt; Oliver T Fackler; Matthias Geyer
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PloS one 2011;6(5):e20033.
2011: Sarah Schmidt; Joëlle V Fritz; Julia Bitzegeio; Oliver T Fackler; Oliver T Keppler
HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction.
mBio 2011;2(3):e00036-11.
2011: Hanna-Mari Tervo; Stefanie Homann; Ina Ambiel; Joëlle V Fritz; Oliver T Fackler; Oliver T Keppler
β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.
Retrovirology 2011;8():9.
2010: Christine Goffinet; Stefanie Homann; Ina Ambiel; Nadine Tibroni; Daniel Rupp; Oliver T Keppler; Oliver T Fackler
Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.
Journal of virology 2010;84(8):4089-94.
2010: Bettina Stolp; Libin Abraham; Jochen M Rudolph; Oliver T Fackler
Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.
Journal of virology 2010;84(8):3935-48.
2009: Jochen M Rudolph; Nina Eickel; Claudia Haller; Michael Schindler; Oliver T Fackler
Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins.
Journal of virology 2009;83(22):11528-39.
2009: Bettina Stolp; Michal Reichman-Fried; Libin Abraham; xiaoyu pan; Simone I Giese; Sebastian Hannemann; Polyxeni Goulimari; Erez Raz; Robert Grosse; Oliver T Fackler
HIV-1 Nef interferes with host cell motility by deregulation of Cofilin.
Cell host & microbe 2009;6(2):174-86.
2009: Christine Goffinet; Ina Allespach; Stefanie Homann; Hanna-Mari Tervo; Anja Habermann; Daniel Rupp; Lena Oberbremer; Christian Kern; Nadine Tibroni; Sonja Welsch; Jacomine Krijnse-Locker; George Banting; Hans-Georg Kräusslich; Oliver T Fackler; Oliver T Keppler
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Cell host & microbe 2009;5(3):285-97.
2009: Stefanie Homann; Nadine Tibroni; Ingo Baumann; Serkan Sertel; Oliver T Keppler; Oliver T Fackler
Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo.
Retrovirology 2009;6():6.
2008: Vanessa Witte; Bernd Laffert; Patricia Gintschel; Ellen Krautkrämer; Katja Blume; Oliver T Fackler; Andreas S Baur
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8425-32.
2008: Sebastian Hannemann; Ricardo Madrid; Jana Stastna; Thomas Kitzing; Judith E Gasteier; André Schönichen; Jérôme Bouchet; Alberto Jimenez; Matthias Geyer; Robert Grosse; Serge Benichou; Oliver T Fackler
The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
The Journal of biological chemistry 2008;283(41):27891-903.
2008: Claudia Haller; Oliver T Fackler
HIV-1 at the immunological and T-lymphocytic virological synapse.
Biological chemistry 2008;389(10):1253-60.
2008: Antje Schulte; Bettina Stolp; André Schönichen; Olena Pylypenko; Alexey Rak; Oliver T Fackler; Matthias Geyer
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.
Structure (London, England : 1993) 2008;16(9):1313-23.
2008: Oliver T Fackler; Robert Grosse
Cell motility through plasma membrane blebbing.
The Journal of cell biology 2008;181(6):879-84.
2008: Susanne Rauch; Kati Pulkkinen; Kalle Saksela; Oliver T Fackler
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
Journal of virology 2008;82(6):2918-29.
2008: Takamasa Ueno; Chihiro Motozono; Sachi Dohki; Philip Mwimanzi; Susanne Rauch; Oliver T Fackler; Shinichi Oka; Masafumi Takiguchi
CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1107-16.
2008: Dietlinde Wolf; Simone I Giese; Vanessa Witte; Ellen Krautkrämer; Susanna Trapp; Gabriele Sass; Claudia Haller; Katja Blume; Oliver T Fackler; Andreas S Baur
Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting.
Virology 2008;370(1):45-54.
2007: Stella Tournaviti; Sebastian Hannemann; Stefan Terjung; Thomas M Kitzing; Carolin Stegmayer; Julia Ritzerfeld; Paul Walther; Robert Grosse; Walter Nickel; Oliver T Fackler
SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility.
Journal of cell science 2007;120(Pt 21):3820-9.
2007: Thomas M Kitzing; Arul S Sahadevan; Dominique T Brandt; Helga Knieling; Sebastian Hannemann; Oliver T Fackler; Jörg Grosshans; Robert Grosse
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.
Genes & development 2007;21(12):1478-83.
2007: Oliver T Fackler; Andrés Alcover; Olivier Schwartz
Modulation of the immunological synapse: a key to HIV-1 pathogenesis?
Nature reviews. Immunology 2007;7(4):310-7.
2007: Claudia Haller; Susanne Rauch; Oliver T Fackler
HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.
PloS one 2007;2(11):e1212.
2007: Britta Brügger; Ellen Krautkrämer; Nadine Tibroni; Claudia Elisabeth Munte; Susanne Rauch; Iris Leibrecht; Bärbel Glass; Sebastian Breuer; Matthias Geyer; Hans-Georg Kräusslich; Hans Robert Kalbitzer; Felix T Wieland; Oliver T Fackler
Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains.
Retrovirology 2007;4():70.
2006: Simone I Giese; Ilka Woerz; Stefanie Homann; Nadine Tibroni; Matthias Geyer; Oliver T Fackler
Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.
Virology 2006;355(2):175-91.
2006: Stephanie Venzke; Nico Michel; Ina Allespach; Oliver T Fackler; Oliver T Keppler
Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.
Journal of virology 2006;80(22):11141-52.
2006: Nicoletta Casartelli; Giorgia Giolo; Francesca Neri; Claudia Haller; Marina Potestà; Paolo Rossi; Oliver T Fackler; Margherita Doria
The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner.
The Journal of general virology 2006;87(Pt 8):2291-6.
2006: Oliver T Fackler; Hans-Georg Kräusslich
Interactions of human retroviruses with the host cell cytoskeleton.
Current opinion in microbiology 2006;9(4):409-15.
2006: Nico Michel; Kerstin Ganter; Stephanie Venzke; Julia Bitzegeio; Oliver T Fackler; Oliver T Keppler
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.
Molecular biology of the cell 2006;17(8):3578-90.
2006: Oliver T Fackler; Arnaud Moris; Nadine Tibroni; Simone I Giese; Bärbel Glass; Olivier Schwartz; Hans-Georg Kräusslich
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
Virology 2006;351(2):322-39.
2006: Claudia Haller; Susanne Rauch; Nico Michel; Sebastian Hannemann; Maik J Lehmann; Oliver T Keppler; Oliver T Fackler
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
The Journal of biological chemistry 2006;281(28):19618-30.
2006: Oliver T Keppler; Nadine Tibroni; Stephanie Venzke; Susanne Rauch; Oliver T Fackler
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.
Journal of leukocyte biology 2006;79(3):616-27.
2006: André Schönichen; Michael Alexander; Judith E Gasteier; Fanny E Cuesta; Oliver T Fackler; Matthias Geyer
Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1.
The Journal of biological chemistry 2006;281(8):5084-93.
2005: Judith E Gasteier; Sebastian Schroeder; Walter Muranyi; Ricardo Madrid; Serge Benichou; Oliver T Fackler
FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation.
Experimental cell research 2005;306(1):192-202.
2005: Nico Michel; Ina Allespach; Stephanie Venzke; Oliver T Fackler; Oliver T Keppler
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.
Current biology : CB 2005;15(8):714-23.
2005: Oliver T Keppler; Ina Allespach; Lismarie Schüller; David Fenard; Warner Greene; Oliver T Fackler
Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.
Journal of virology 2005;79(3):1655-65.
2005: Jessica Daecke; Oliver T Fackler; Matthias T Dittmar; Hans-Georg Kräusslich
Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry.
Journal of virology 2005;79(3):1581-94.
2005: Ricardo Madrid; Judith E Gasteier; Jérôme Bouchet; Sebastian Schröder; Matthias Geyer; Serge Benichou; Oliver T Fackler
Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities.
FEBS letters 2005;579(2):441-8.
2005: Sheriff Aziz; Oliver T Fackler; Andreas Meyerhans; Nikolaus Müller-Lantzsch; Martin Zeitz; Thomas Schneider
Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa.
Journal of acquired immune deficiency syndromes (1999) 2005;38(1):23-30.
2004: Barbara Müller; Jessica Daecke; Oliver T Fackler; Matthias T Dittmar; Hanswalter Zentgraf; Hans-Georg Kräusslich
Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivative.
Journal of virology 2004;78(19):10803-13.
2004: Denis M Tebit; Leopold Zekeng; Lazare Kaptué; Lutz Gürtler; Oliver T Fackler; Oliver T Keppler; Ottmar Herchenröder; Hans-Georg Kräusslich
Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives.
Virology 2004;326(2):329-39.
2004: Luciana J Costa; Yong-Hui Zheng; Jerica Sabotic; Johnson Mak; Oliver T Fackler; B Matija Peterlin
Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.
Journal of virology 2004;78(10):5311-23.
2004: Ellen Krautkrämer; Simone I Giese; Judith E Gasteier; Walter Muranyi; Oliver T Fackler
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.
Journal of virology 2004;78(8):4085-97.
2003: Judith E Gasteier; Ricardo Madrid; Ellen Krautkrämer; Sebastian Schröder; Walter Muranyi; Serge Benichou; Oliver T Fackler
Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism.
The Journal of biological chemistry 2003;278(40):38902-12.
2002: Matthias Geyer; Haifeng Yu; Robert Mandic; Thomas Linnemann; Yong-Hui Zheng; Oliver T Fackler; B Matija Peterlin
Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.
The Journal of biological chemistry 2002;277(32):28521-9.
2002: Matthias Geyer; Oliver T Fackler; B Matija Peterlin
Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins.
Molecular biology of the cell 2002;13(6):2045-56.
2002: Oliver T Fackler; Andreas S Baur
Live and let die: Nef functions beyond HIV replication.
Immunity 2002;16(4):493-7.
2001: Oliver T Fackler; D Wolf; H Oliver Weber; Bernd Laffert; Paola D'Aloja; B Schuler-Thurner; Rebeca Benzaquen Geffin; K Saksela; Matthias Geyer; B Matija Peterlin; Gerold Schuler; Andreas S Baur
A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.
Current biology : CB 2001;11(16):1294-9.
2001: Matthias Geyer; Oliver T Fackler; B Matija Peterlin
Structure--function relationships in HIV-1 Nef.
EMBO reports 2001;2(7):580-5.
2001: Oliver T Fackler; Paola D'Aloja; Andreas S Baur; Maurizio Federico; B Matija Peterlin
Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity.
Journal of virology 2001;75(14):6601-8.
2001: Yong-Hui Zheng; Ana Plemenitas; Thomas Linnemann; Oliver T Fackler; B Matija Peterlin
Nef increases infectivity of HIV via lipid rafts.
Current biology : CB 2001;11(11):875-9.
2001: Oliver T Fackler; B Matija Peterlin; Karsten Weis
Lessons from HIV: movement of macromolecules inside the cell.
Current molecular medicine 2001;1(1):1-7.
2001: Robert Mandic; Oliver T Fackler; Matthias Geyer; Thomas Linnemann; Yong-Hui Zheng; B Matija Peterlin
Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.
Molecular biology of the cell 2001;12(2):463-73.
2000: Oliver T Fackler; B Matija Peterlin
Endocytic entry of HIV-1.
Current biology : CB 2000;10(16):1005-8.
2000: LX Liu; N Heveker; Oliver T Fackler; Stefan T Arold; S Le Gall; Katy Janvier; B M Peterlin; Christian DUMAS; Olivier Schwartz; Serge Benichou; Richard Benarous
Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.
Journal of virology 2000;74(11):5310-9.
2000: Oliver T Fackler; X Lu; Jeffrey A Frost; Matthias Geyer; B Jiang; W Luo; A Abo; ARTHUR S ALBERTS; B Matija Peterlin
p21-activated kinase 1 plays a critical role in cellular activation by Nef.
Molecular and cellular biology 2000;20(7):2619-27.
1999: Oliver T Fackler; W Luo; Matthias Geyer; ARTHUR S ALBERTS; B Matija Peterlin
Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.
Molecular cell 1999;3(6):729-39.