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Michael Brownlee

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Michael Brownlee
Hyperglycemia-stimulated myelopoiesis causes impaired regression of atherosclerosis in type 1 diabetes.
A K Berner; S Brockbank; O Brouwers; Michael Brownlee; L Colhoun; J W Curry; Ingeborg Klaassen; Carmel M McVicar; T Miyata; R Pringle; Casper G Schalkwijk; Reinier O Schlingemann; Alan Stitt
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.
Tomoaki Uchiki; Karen A Weikel; Michael Brownlee; Andrea Caceres; James T Handa; Wangwang Jiao; Ram Nagaraj; Dorota Pawlak; Fu Shang; Allen Taylor
Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics).

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All Publications

2013: Michael Brownlee
Hyperglycemia-stimulated myelopoiesis causes impaired regression of atherosclerosis in type 1 diabetes.
Cell metabolism 2013;17(5):631-3.
2012: A K Berner; S Brockbank; O Brouwers; Michael Brownlee; L Colhoun; J W Curry; Ingeborg Klaassen; Carmel M McVicar; T Miyata; R Pringle; Casper G Schalkwijk; Reinier O Schlingemann; Alan Stitt
Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.
Diabetologia 2012;55(3):845-54.
2012: Tomoaki Uchiki; Karen A Weikel; Michael Brownlee; Andrea Caceres; James T Handa; Wangwang Jiao; Ram Nagaraj; Dorota Pawlak; Fu Shang; Allen Taylor
Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics).
Aging cell 2012;11(1):1-13.
2011: Olaf Brouwers; Petra M Niessen; Isabel Ferreira; Toshio Miyata; Peter G Scheffer; Tom Teerlink; Patrick Schrauwen; Michael Brownlee; Coen D Stehouwer; Casper G Schalkwijk
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.
The Journal of biological chemistry 2011;286(2):1374-80.
2011: Hans-Peter Hammes; Yuxi Feng; Frederick Pfister; Michael Brownlee
Diabetic retinopathy: targeting vasoregression.
Diabetes 2011;60(1):9-16.
2010: Ferdinando Giacco; Michael Brownlee
Oxidative stress and diabetic complications.
Circulation research 2010;107(9):1058-70.
2010: Irl B Hirsch; Michael Brownlee
Beyond hemoglobin A1c--need for additional markers of risk for diabetic microvascular complications.
JAMA : the journal of the American Medical Association 2010;303(22):2291-2.
2010: Andreas Schlotterer; Andreas Hamann; Georgi Kukudov; Youssef Ibrahim; Britta Heckmann; Farastuk Bozorgmehr; Michael Pfeiffer; Harald Hutter; David Stern; Xue-Liang Du; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
Aging cell 2010;9(3):420-32.
2010: O Brouwers; P M Niessen; G Haenen; T Miyata; Michael Brownlee; Coen D A Stehouwer; Jo De Mey; Casper G Schalkwijk
Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.
Diabetologia 2010;53(5):989-1000.
2010: Markus A Queisser; Dachun Yao; Sven Geisler; Hans-Peter Hammes; Günter Lochnit; Erwin D Schleicher; Michael Brownlee; Klaus T Preissner
Hyperglycemia impairs proteasome function by methylglyoxal.
Diabetes 2010;59(3):670-8.
2010: Franco Folli; Valeria Guzzi; Lucia Perego; Dawn K Coletta; Giovanna Finzi; Claudia Placidi; Stefano La Rosa; Carlo Capella; Carlo Socci; Davide Lauro; Devjit Tripathy; Christopher Jenkinson; Rita Paroni; Elena Orsenigo; Giuliana Cighetti; Luisa Gregorini; Carlo Staudacher; Antonio Secchi; Angela Bachi; Michael Brownlee; Paolo Fiorina
Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation.
PloS one 2010;5(3):e9923.
2010: Hariharan Thangarajah; Ivan N Vial; Raymon H Grogan; Dachun Yao; Yubin Shi; Michael Januszyk; Robert D Galiano; Edward I Chang; Michael G Galvez; Jason P Glotzbach; Victor W Wong; Michael Brownlee; Geoffrey C Gurtner
HIF-1alpha dysfunction in diabetes.
Cell cycle (Georgetown, Tex.) 2010;9(1):75-9.
2010: Maria D'Apolito; Xue-Liang Du; Haihong Zong; Alessandra Catucci; Luigi Maiuri; Tiziana Trivisano; Massimo Pettoello-Mantovani; Angelo Campanozzi; Valeria Raia; Jeffrey Pessin; Michael Brownlee; Ida Giardino
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.
The Journal of clinical investigation 2010;120(1):203-13.
2010: Dachun Yao; Michael Brownlee
Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands.
Diabetes 2010;59(1):249-55.
2009: Andreas Schlotterer; Georgi Kukudov; Farastuk Bozorgmehr; Harald Hutter; Xue-Liang Du; Dimitrios Oikonomou; Youssef Ibrahim; Friederike Pfisterer; Naila Rabbani; Paul Thornalley; Ahmed A R Sayed; Thomas Fleming; Per M Humpert; Vedat Schwenger; Martin Zeier; Andreas Hamann; David Stern; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
C. elegans as model for the study of high glucose- mediated life span reduction.
Diabetes 2009;58(11):2450-6.
2009: Hariharan Thangarajah; Dachun Yao; Edward I Chang; Yubin Shi; Leila Jazayeri; Ivan N Vial; Robert D Galiano; Xue-Liang Du; Raymon Grogan; Michael G Galvez; Michael Januszyk; Michael Brownlee; Geoffrey C Gurtner
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13505-10.
2009: Heng Ma; Shi-Yan Li; Peisheng Xu; Sara A Babcock; E Kurt Dolence; Michael Brownlee; Ji Li; Jun Ren
Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy.
Journal of cellular and molecular medicine 2009;13(8B):1751-64.
2009: Jingbo Pi; Yushi Bai; Kiefer W Daniel; Dianxin Liu; Otis Lyght; Diane Edelstein; Michael Brownlee; Barbara E Corkey; Sheila Collins
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.
Endocrinology 2009;150(7):3040-8.
2009: Daniella Brasacchio; Jun Okabe; Christos Tikellis; Aneta Balcerczyk; Prince George; Emma K Baker; Anna C Calkin; Michael Brownlee; Mark E Cooper; Assam El-Osta
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Diabetes 2009;58(5):1229-36.
2009: Melinda Coughlan; David R Thorburn; Sally A Penfold; Adrienne Laskowski; Brooke E Harcourt; Karly Sourris; Adeline L Y Tan; Kei Fukami; Vicki Thallas; Peter P Nawroth; Michael Brownlee; Angelika Bierhaus; Mark E Cooper; Josephine M Forbes
RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.
Journal of the American Society of Nephrology : JASN 2009;20(4):742-52.
2008: Xue-Liang Du; Diane Edelstein; Michael Brownlee
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Diabetologia 2008;51(10):1930-2.
2008: Assam El-Osta; Daniella Brasacchio; Dachun Yao; Alessandro Pocai; Peter L Jones; Robert G Roeder; Mark E Cooper; Michael Brownlee
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.
The Journal of experimental medicine 2008;205(10):2409-17.
2008: Zhao V Wang; James Mu; Todd D Schraw; Laurent Gautron; Joel K Elmquist; Bei B Zhang; Michael Brownlee; Philipp E Scherer
PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.
Diabetes 2008;57(8):2137-48.
2008: Daniel J Ceradini; Dachun Yao; Raymon H Grogan; Matthew J Callaghan; Diane Edelstein; Michael Brownlee; Geoffrey C Gurtner
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.
The Journal of biological chemistry 2008;283(16):10930-8.
2008: Michael Morcos; Xue-Liang Du; Friederike Pfisterer; Harald Hutter; Ahmed A R Sayed; Paul Thornalley; Naila Ahmed; John W Baynes; Suzanne R Thorpe; Georgi Kukudov; Andreas Schlotterer; Farastuk Bozorgmehr; Randa Abd El Baki; David M Stern; Frank Moehrlen; Youssef Ibrahim; Dimitrios Oikonomou; Andreas Hamann; Christian Becker; Martin Zeier; Vedat Schwenger; Nexhat Miftari; Per Humpert; Hans-Peter Hammes; Markus Buechler; Angelika Bierhaus; Michael Brownlee; Peter P Nawroth
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
Aging cell 2008;7(2):260-9.
2007: Michael Brownlee
Preventing kidney cell suicide.
Nature medicine 2007;13(11):1284-5.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Rabbani; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.
The Journal of biological chemistry 2007;282(42):31038-45.
2007: Miyuki Yano; Takeshi Matsumura; Takafumi Senokuchi; Norio Ishii; Yusuke Murata; Kayo Taketa; Hiroyuki Motoshima; Tetsuya Taguchi; Kazuhiro Sonoda; Daisuke Kukidome; Yoh Takuwa; Teruo Kawada; Michael Brownlee; Takeshi Nishikawa; Eiichi Araki
Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.
Circulation research 2007;100(10):1442-51.
2007: joseph nissimov; Uriel Elchalal; Hilaire Bakala; Michael Brownlee; Elliot Berry; Moshe Phillip; Yoram Milner
Method for chronological recording of antigen appearance in human head-hair shafts and its use for monitoring glycation products in diabetes.
Journal of immunological methods 2007;320(1-2):1-17.
2007: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2007;128(3):625.
2007: Irl B Hirsch; Michael Brownlee
The effect of glucose variability on the risk of microvascular complications in type 1 diabetes.
Diabetes care 2007;30(1):186-7; author reply 188-9.
2006: Jihong Lin; Angelika Bierhaus; P Bugert; N Dietrich; Yuxi Feng; Franziska Vom Hagen; Peter Nawroth; Michael Brownlee; Hans-Peter Hammes
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Diabetologia 2006;49(5):1089-96.
2006: Michael Brownlee; Irl B Hirsch
Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications.
JAMA : the journal of the American Medical Association 2006;295(14):1707-8.
2006: Jennifer Hoffmann; Alex Alt; Jihong Lin; Günther Lochnit; Uwe Schubert; Erwin Schleicher; Triantafyllos Chavakis; Michael Brownlee; Fokko J van der Woude; Klaus T Preissner; Hans-Peter Hammes
Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss.
Thrombosis and haemostasis 2006;95(4):689-95.
2006: Xue-Liang Du; Diane Edelstein; Silvana Obici; Ninon Higham; Ming-Hui Zou; Michael Brownlee
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation.
The Journal of clinical investigation 2006;116(4):1071-80.
2006: Dachun Yao; Tetsuya Taguchi; Takeshi Matsumura; Richard G Pestell; Diane Edelstein; Ida Giardino; Guntram Suske; Naila Ahmed; Paul J Thornalley; Vijay P Sarthy; Hans-Peter Hammes; Michael Brownlee
Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.
Cell 2006;124(2):275-86.
2006: N R F Nascimento; Lucília Maria Abreu Lessa; Marta Regina Kerntopf; C M Sousa; Renata Sousa Alves; M G R Queiroz; J Price; Douglas B Heimark; James M Larner; Xue-Liang Du; Michael Brownlee; Alexander Gow; C Davis; Manassés C Fonteles
Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):218-23.
2005: Mariana G Rosca; Tiberiu G Mustata; Michael Kinter; Aylin M Ozdemir; Timothy S Kern; Luke I Szweda; Michael Brownlee; Vincent M Monnier; Miriam F Weiss
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
American journal of physiology. Renal physiology 2005;289(2):F420-30.
2005: Michael Brownlee
The pathobiology of diabetic complications: a unifying mechanism.
Diabetes 2005;54(6):1615-25.
2005: Irl B Hirsch; Michael Brownlee
Should minimal blood glucose variability become the gold standard of glycemic control?
Journal of diabetes and its complications 2005;19(3):178-81.
2005: Ying Lin; Anders H Berg; Puneeth Iyengar; Tony K T Lam; Adria Giacca; Terry P Combs; Michael W Rajala; Xue-Liang Du; Brent Rollman; Weijie Li; Meredith Hawkins; Nir Barzilai; Christopher J Rhodes; I George Fantus; Michael Brownlee; Philipp E Scherer
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
The Journal of biological chemistry 2005;280(6):4617-26.
2005: Georgian T Mustata; Mariana G Rosca; Klaus M Biemel; Oliver Reihl; Mark A. Smith; Ashwini Viswanathan; Christopher M Strauch; Yunpeng Du; Jie Tang; Timothy S Kern; Markus O Lederer; Michael Brownlee; Miriam F Weiss; Vincent M Monnier
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.
Diabetes 2005;54(2):517-26.
2004: Angela M Valverde; Cecilia Mur; Michael Brownlee; Manuel Benito
Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.
Molecular biology of the cell 2004;15(11):5101-17.
2004: Ming-Hui Zou; Stacy S Kirkpatrick; Bradley J Davis; John S Nelson; Walter G Wiles; Uwe Schlattner; Dietbert Neumann; Michael Brownlee; Michael B Freeman; Mitchell H Goldman
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.
The Journal of biological chemistry 2004;279(42):43940-51.
2004: Suseela Srinivasan; Melissa E Hatley; David T Bolick; Lisa A Palmer; Diane Edelstein; Michael Brownlee; Catherine C Hedrick
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells.
Diabetologia 2004;47(10):1727-34.
2004: Qiusheng Si; Melissa Cosenza; Mee-Ohk Kim; Meng-Liang Zhao; Michael Brownlee; Harris Goldstein; Sunhee C Lee
A novel action of minocycline: inhibition of human immunodeficiency virus type 1 infection in microglia.
Journal of neurovirology 2004;10(5):284-92.
2004: Hans-Peter Hammes; Jihong Lin; Patrick Wagner; Yuxi Feng; Franziska Vom Hagen; Thomas Krzizok; Oliver Renner; Georg Breier; Michael Brownlee; Urban Deutsch
Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.
Diabetes 2004;53(4):1104-10.
2004: Andrea M Vincent; James Olzmann; Michael Brownlee; W I Sivitz; James W Russell
Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death.
Diabetes 2004;53(3):726-34.
2004: Tomoko Matsuo; Takeshi Matsumura; Masakazu Sakai; Takafumi Senokuchi; Miyuki Yano; Shinsuke Kiritoshi; Kazuhiro Sonoda; Daisuke Kukidome; Richard G Pestell; Michael Brownlee; Takeshi Nishikawa; Eiichi Araki
15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB.
Biochemical and biophysical research communications 2004;314(3):817-23.
2003: Michael Brownlee
A radical explanation for glucose-induced beta cell dysfunction.
The Journal of clinical investigation 2003;112(12):1788-90.
2003: Xue-Liang Du; Takeshi Matsumura; Diane Edelstein; Luciano Rossetti; Zsuzsanna Zsengellér; Csaba Szabó; Michael Brownlee
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
The Journal of clinical investigation 2003;112(7):1049-57.
2003: Shinsuke Kiritoshi; Takeshi Nishikawa; Kazuhiro Sonoda; Daisuke Kukidome; Takafumi Senokuchi; Tomoko Matsuo; Takeshi Matsumura; Hiroshi Tokunaga; Michael Brownlee; Eiichi Araki
Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy.
Diabetes 2003;52(10):2570-7.
2003: Chenguang Wang; Nagarajan Pattabiraman; Jian-nian Zhou; Maofu Fu; Toshiyuki Sakamaki; Chris Albanese; Zhiping Li; Kongming Wu; James Hulit; Peter Neumeister; Phyllis M Novikoff; Michael Brownlee; Philipp E Scherer; Joan G Jones; Kathleen D Whitney; Lawrence A Donehower; Emily L Harris; Thomas E Rohan; David C Johns; Richard G Pestell
Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.
Molecular and cellular biology 2003;23(17):6159-73.
2003: Utpal B Pajvani; Xue-Liang Du; Terry P Combs; Anders H Berg; Michael W Rajala; Therese Schulthess; Jürgen Engel; Michael Brownlee; Philipp E Scherer
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.
The Journal of biological chemistry 2003;278(11):9073-85.
2003: Hans-Peter Hammes; Xue-Liang Du; Diane Edelstein; Tetsuya Taguchi; Takeshi Matsumura; Qida Ju; Jihong Lin; Angelika Bierhaus; Peter Nawroth; Dieter Hannak; Michael Neumaier; Regine Bergfeld; Ida Giardino; Michael Brownlee
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Nature medicine 2003;9(3):294-9.
2003: Bente K Kilhovd; Ida Giardino; Peter A Torjesen; K I Birkeland; Tore J Berg; Paul J Thornalley; Michael Brownlee; Kristian F Hanssen
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
Metabolism: clinical and experimental 2003;52(2):163-7.
2003: Koji Sakai; Kazuya Matsumoto; Takeshi Nishikawa; Mihoshi Suefuji; Kazuhiko Nakamaru; Yoshiaki Hirashima; Junji Kawashima; Tetsuya Shirotani; Kenshi Ichinose; Michael Brownlee; Eiichi Araki
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells.
Biochemical and biophysical research communications 2003;300(1):216-22.
2002: Hans-Peter Hammes; Jihong Lin; Oliver Renner; Moshe Shani; Andrea Lundqvist; Christer Betsholtz; Michael Brownlee; Urban Deutsch
Pericytes and the pathogenesis of diabetic retinopathy.
Diabetes 2002;51(10):3107-12.
2002: Andrea M Vincent; Michael Brownlee; James W Russell
Oxidative stress and programmed cell death in diabetic neuropathy.
Annals of the New York Academy of Sciences 2002;959():368-83.
2002: E Chavakis; B Riecke; Jihong Lin; Thomas Linn; Reinhard Bretzel; Klaus T Preissner; Michael Brownlee; Hans-Peter Hammes
Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides.
Diabetologia 2002;45(2):262-7.
2002: Diana Casper; Samara J Engstrom; Gautam R Mirchandani; Ann Pidel; David Palencia; Paul H Cho; Michael Brownlee; Diane Edelstein; Howard Federoff; William J Sonstein
Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.
Cell transplantation 2002;11(4):331-49.
2001: Michael Brownlee
Biochemistry and molecular cell biology of diabetic complications.
Nature 2001;414(6865):813-20.
2001: Xue-Liang Du; Diane Edelstein; S Dimmeler; Qida Ju; C Sui; Michael Brownlee
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
The Journal of clinical investigation 2001;108(9):1341-8.
2001: Anders H Berg; Terry P Combs; Xue-Liang Du; Michael Brownlee; Philipp E Scherer
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.
Nature medicine 2001;7(8):947-53.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Y Kaneda; M Guzmán; Michael Brownlee
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.
The Journal of biological chemistry 2001;276(27):25096-100.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Michael Brownlee
Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction.
Diabetes 2001;50(6):1491-4.
2001: B Riecke; E Chavakis; Reinhard Bretzel; Thomas Linn; Klaus T Preissner; Michael Brownlee; Hans-Peter Hammes
Topical application of integrin antagonists inhibits proliferative retinopathy.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(5):307-11.
2001: C Wang; M Fu; M D'Amico; C Albanese; J N Zhou; Michael Brownlee; M P Lisanti; V K Chatterjee; Mitchell Lazar; R G Pestell
Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.
Molecular and cellular biology 2001;21(9):3057-70.
2001: Ari D Brooks; B Ng; D Liu; Michael Brownlee; M Burt; Howard Federoff; Yuman Fong
Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy.
Surgery 2001;129(3):324-34.
2000: Inga Golovchenko; Marc L Goalstone; P Watson; Michael Brownlee; Boris Draznin
Hyperinsulinemia enhances transcriptional activity of nuclear factor-kappaB induced by angiotensin II, hyperglycemia, and advanced glycosylation end products in vascular smooth muscle cells.
Circulation research 2000;87(9):746-52.
2000: Xue-Liang Du; Diane Edelstein; L Rossetti; I George Fantus; Howard Goldberg; F Ziyadeh; J Wu; Michael Brownlee
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12222-6.
2000: Takeshi Nishikawa; Diane Edelstein; Michael Brownlee
The missing link: a single unifying mechanism for diabetic complications.
Kidney international. Supplement 2000;77():S26-30.
2000: T Nishikawa; Ida Giardino; Diane Edelstein; Michael Brownlee
Changes in diabetic retinal matrix protein mRNA levels in a common transgenic mouse strain.
Current eye research 2000;21(1):581-7.
2000: T Nishikawa; Diane Edelstein; Xue-Liang Du; SI Yamagishi; Takeshi Matsumura; Y Kaneda; M A Yorek; D Beebe; Peter Oates; Hans-Peter Hammes; Ida Giardino; Michael Brownlee
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Nature 2000;404(6779):787-90.
2000: HM Karpoff; David A Kooby; Michael D'Angelica; J Mack; D H Presky; Michael Brownlee; Howard Federoff; Yuman Fong
Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production.
Cancer gene therapy 2000;7(4):581-8.
2000: Michael Brownlee
Negative consequences of glycation.
Metabolism: clinical and experimental 2000;49(2 Suppl 1):9-13.
1999: Michael D'Angelica; C Tung; Peter J Allen; Marc W Halterman; Keith A Delman; TM Delohery; David S Klimstra; Michael Brownlee; Howard Federoff; Yuman Fong
Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity.
Molecular medicine (Cambridge, Mass.) 1999;5(9):606-16.
1999: Hans-Peter Hammes; A Alt; T Niwa; J T Clausen; Reinhard Bretzel; Michael Brownlee; E D Schleicher
Differential accumulation of advanced glycation end products in the course of diabetic retinopathy.
Diabetologia 1999;42(6):728-36.
1999: Alex Rabinovitch; Wilma L Suarez-Pinzon; Ken Strynadka; Qida Ju; Diane Edelstein; Michael Brownlee; Gregory S Korbutt; Ray V Rajotte
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Diabetes 1999;48(6):1223-9.
1999: Hans-Peter Hammes; Michael Brownlee; Jihong Lin; E Schleicher; Reinhard Bretzel
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations.
Diabetologia 1999;42(5):603-7.
1999: Michael Brownlee
[Biochemical bases of aging: does glucose play a role?].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1999;():55-62.
1999: Michael D'Angelica; HM Karpoff; Marc W Halterman; J Ellis; David S Klimstra; Diane Edelstein; Michael Brownlee; Howard Federoff; Yuman Fong
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Cancer immunology, immunotherapy : CII 1999;47(5):265-71.
1999: Michael Brownlee
Generation of nonimmune islet cells using genetic engineering.
Journal of molecular medicine (Berlin, Germany) 1999;77(1):230-4.
1998: Ida Giardino; A K Fard; D L Hatchell; Michael Brownlee
Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.
Diabetes 1998;47(7):1114-20.
1998: Qida Ju; Diane Edelstein; M D Brendel; D Brandhorst; H Brandhorst; R G Bretzel; Michael Brownlee
Transduction of non-dividing adult human pancreatic beta cells by an integrating lentiviral vector.
Diabetologia 1998;41(6):736-9.
1998: Hans-Peter Hammes; Jihong Lin; Reinhard Bretzel; Michael Brownlee; Georg Breier
Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat.
Diabetes 1998;47(3):401-6.
1998: M Shinohara; Paul J Thornalley; Ida Giardino; Paul J Beisswenger; Suzanne R Thorpe; JM Onorato; Michael Brownlee
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
The Journal of clinical investigation 1998;101(5):1142-7.
1998: Hans-Peter Hammes; B Wellensiek; I Klöting; E Sickel; Reinhard Bretzel; Michael Brownlee
The relationship of glycaemic level to advanced glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster.
Diabetologia 1998;41(2):165-70.
1997: Sarah Ferber; H Heimberg; Michael Brownlee; C Colton
Surrogate beta cells.
Diabetologia 1997;40 Suppl 3():B39-43.
1997: HM Karpoff; Michael D'Angelica; S Blair; Michael Brownlee; Howard Federoff; Yuman Fong
Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.
The Journal of clinical investigation 1997;99(4):799-804.
1997: Jack L Arbiser; Marsha A Moses; CA Fernandez; N Ghiso; Y Cao; Nancy Demore; D Frank; Michael Brownlee; Evelyn Flynn; S Parangi; HR Byers; Judah Folkman
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(3):861-6.
1996: C Tung; Howard Federoff; Michael Brownlee; HM Karpoff; T Weigel; Murray F Brennan; Yuman Fong
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Human gene therapy 1996;7(18):2217-24.
1996: Y Liu; Alex Rabinovitch; Wilma L Suarez-Pinzon; B Muhkerjee; Michael Brownlee; Diane Edelstein; Howard Federoff
Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis.
Human gene therapy 1996;7(14):1719-26.
1996: Hans-Peter Hammes; A Weiss; S Hess; N Araki; S Horiuchi; Michael Brownlee; Klaus T Preissner
Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina.
Laboratory investigation; a journal of technical methods and pathology 1996;75(3):325-38.
1996: G L King; Michael Brownlee
The cellular and molecular mechanisms of diabetic complications.
Endocrinology and metabolism clinics of North America 1996;25(2):255-70.
1996: Hans-Peter Hammes; Michael Brownlee; A Jonczyk; A Sutter; Klaus T Preissner
Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization.
Nature medicine 1996;2(5):529-33.
1996: Ida Giardino; Diane Edelstein; Michael Brownlee
BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.
The Journal of clinical investigation 1996;97(6):1422-8.
1995: Yuman Fong; Howard Federoff; Michael Brownlee; D Blumberg; Leslie H Blumgart; Murray F Brennan
Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors.
Hepatology (Baltimore, Md.) 1995;22(3):723-9.
1995: Michael Brownlee
The pathological implications of protein glycation.
Clinical and investigative medicine. Médecine clinique et experimentale 1995;18(4):275-81.
1995: S Efrat; G Fejer; Michael Brownlee; M S Horwitz
Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6947-51.
1995: Hans-Peter Hammes; Howard Federoff; Michael Brownlee
Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes.
Molecular medicine (Cambridge, Mass.) 1995;1(5):527-34.
1995: S L Winer; Robert Bases; I Lalezari; Michael Brownlee; William A Franklin
Evaluation of 2-(3-aminobenzamido)-2-deoxy-D-glucose as a radiosensitizer.
Radiology 1995;196(1):267-9.
1995: Hans-Peter Hammes; D Strödter; A Weiss; R G Bretzel; KF Federlin; Michael Brownlee
Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat model.
Diabetologia 1995;38(6):656-60.
1995: Hans-Peter Hammes; S S Ali; M Uhlmann; A Weiss; KF Federlin; K Geisen; Michael Brownlee
Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in rats.
Diabetologia 1995;38(3):269-73.
1995: Enrique Mesri; Howard Federoff; Michael Brownlee
Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice.
Circulation research 1995;76(2):161-7.
1995: Michael Brownlee
Advanced protein glycosylation in diabetes and aging.
Annual review of medicine 1995;46():223-34.
1994: Ida Giardino; Diane Edelstein; Michael Brownlee
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.
The Journal of clinical investigation 1994;94(1):110-7.
1994: Michael Brownlee
Lilly Lecture 1993. Glycation and diabetic complications.
Diabetes 1994;43(6):836-41.
1994: Eduard Mullokandov; William A Franklin; Michael Brownlee
DNA damage by the glycation products of glyceraldehyde 3-phosphate and lysine.
Diabetologia 1994;37(2):145-9.
1994: Stuart C Apfel; Joseph C Arezzo; Michael Brownlee; Howard Federoff; John A Kessler
Nerve growth factor administration protects against experimental diabetic sensory neuropathy.
Brain research 1994;634(1):7-12.
1994: Hans-Peter Hammes; Michael Brownlee; D Edelstein; M Saleck; S Martin; KF Federlin
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat.
Diabetologia 1994;37(1):32-5.
1993: P Casaccia-Bonnefil; E Benedikz; H Shen; A Stelzer; Diane Edelstein; M Geschwind; Michael Brownlee; Howard Federoff; Peter Bergold
Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices.
Journal of neuroscience methods 1993;50(3):341-51.
1993: Yuman Fong; Diane Edelstein; E A Wang; Michael Brownlee
Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats.
Diabetologia 1993;36(9):802-7.
1993: Sharon Silbiger; S Crowley; Z Shan; Michael Brownlee; J Satriano; D Schlondorff
Nonenzymatic glycation of mesangial matrix and prolonged exposure of mesangial matrix to elevated glucose reduces collagen synthesis and proteoglycan charge.
Kidney international 1993;43(4):853-64.
1993: Howard Federoff; D Lawrence; Michael Brownlee
Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth.
Diabetes 1993;42(4):509-13.
1992: Michael Brownlee
Glycation products and the pathogenesis of diabetic complications.
Diabetes care 1992;15(12):1835-43.
1992: Michael Brownlee
Nonenzymatic glycosylation of macromolecules. Prospects of pharmacologic modulation.
Diabetes 1992;41 Suppl 2():57-60.
1992: Neil B Ruderman; J R Williamson; Michael Brownlee
Glucose and diabetic vascular disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(11):2905-14.
1992: C S Haitoglou; Effie C Tsilibary; Michael Brownlee; AS Charonis
Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen.
The Journal of biological chemistry 1992;267(18):12404-7.
1992: Sanjeev Gupta; V Rifici; S Crowley; Michael Brownlee; Z Shan; D Schlondorff
Interactions of LDL and modified LDL with mesangial cells and matrix.
Kidney international 1992;41(5):1161-9.
1992: Jacob J Steinberg; Antonio Cajigas; Michael Brownlee
Enzymatic shot-gun 5'-phosphorylation and 3'-sister phosphate exchange: a two-dimensional thin-layer chromatographic technique to measure DNA deoxynucleotide modification.
Journal of chromatography 1992;574(1):41-55.
1992: Michael Brownlee
Glycosylation of proteins and microangiopathy.
Hospital practice (Office ed.) 1992;27 Suppl 1():46-50.
1992: Diane Edelstein; Michael Brownlee
Mechanistic studies of advanced glycosylation end product inhibition by aminoguanidine.
Diabetes 1992;41(1):26-9.
1992: D Edelstein; Michael Brownlee
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats.
Diabetologia 1992;35(1):96-7.
1991: Hans-Peter Hammes; S Martin; KF Federlin; K Geisen; Michael Brownlee
Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11555-8.
1991: S T Crowley; Michael Brownlee; Diane Edelstein; J A Satriano; T Mori; Pravin Singhal; D O Schlondorff
Effects of nonenzymatic glycosylation of mesangial matrix on proliferation of mesangial cells.
Diabetes 1991;40(5):540-7.
1991: Michael Brownlee
Glycosylation products as toxic mediators of diabetic complications.
Annual review of medicine 1991;42():159-66.
1990: C J Mullarkey; Diane Edelstein; Michael Brownlee
Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes.
Biochemical and biophysical research communications 1990;173(3):932-9.
1989: H Vlassara; Michael Brownlee; A Cerami
Advanced non-enzymatic tissue glycosylation: significance in late diabetic complications.
Diabetes research and clinical practice 1989;7 Suppl 1():S103-8.
1989: Michael Brownlee
Pharmacological modulation of the advanced glycosylation reaction.
Progress in clinical and biological research 1989;304():235-48.
1989: H Vlassara; Michael Brownlee; Anthony Cerami
Macrophage receptor-mediated processing and regulation of advanced glycosylation endproduct (AGE)-modified proteins: role in diabetes and aging.
Progress in clinical and biological research 1989;304():205-18.
1988: A Cerami; H Vlassara; Michael Brownlee
Role of advanced glycosylation products in complications of diabetes.
Diabetes care 1988;11 Suppl 1():73-9.
1988: Michael Brownlee; A Cerami; H Vlassara
Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease.
Diabetes/metabolism reviews 1988;4(5):437-51.
1988: H Vlassara; Michael Brownlee; K R Manogue; C A Dinarello; A Pasagian
Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.
Science (New York, N.Y.) 1988;240(4858):1546-8.
1988: Michael Brownlee; A Cerami; H Vlassara
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications.
The New England journal of medicine 1988;318(20):1315-21.
1988: H Vlassara; Michael Brownlee; Anthony Cerami
Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo.
Diabetes 1988;37(4):456-61.
1987: H Vlassara; J Valinsky; Michael Brownlee; Carla Hand; S Nishimoto; A Cerami
Advanced glycosylation endproducts on erythrocyte cell surface induce receptor-mediated phagocytosis by macrophages. A model for turnover of aging cells.
The Journal of experimental medicine 1987;166(2):539-49.
1987: A Cerami; H Vlassara; Michael Brownlee
Glucose and aging.
Scientific American 1987;256(5):90-6.
1986: H Vlassara; Michael Brownlee; A Cerami
Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors.
The Journal of experimental medicine 1986;164(4):1301-9.
1986: H Vlassara; Michael Brownlee; A Cerami
Nonenzymatic glycosylation: role in the pathogenesis of diabetic complications.
Clinical chemistry 1986;32(10 Suppl):B37-41.
1986: Michael Brownlee; H Vlassara; A Cerami
Trapped immunoglobulins on peripheral nerve myelin from patients with diabetes mellitus.
Diabetes 1986;35(9):999-1003.
1986: Michael Brownlee; H Vlassara; A Kooney; P Ulrich; A Cerami
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Science (New York, N.Y.) 1986;232(4758):1629-32.
1986: A Cerami; H Vlassara; Michael Brownlee
Role of nonenzymatic glycosylation in atherogenesis.
Journal of cellular biochemistry 1986;30(2):111-20.
1985: A Cerami; H Vlassara; Michael Brownlee
Protein glycosylation and the pathogenesis of atherosclerosis.
Metabolism: clinical and experimental 1985;34(12 Suppl 1):37-42.
1985: Michael Brownlee; H Vlassara; A Cerami
Nonenzymatic glycosylation products on collagen covalently trap low-density lipoprotein.
Diabetes 1985;34(9):938-41.
1985: H Vlassara; Michael Brownlee; A Cerami
High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5588-92.
1985: H Vlassara; Michael Brownlee; A Cerami
Recognition and uptake of human diabetic peripheral nerve myelin by macrophages.
Diabetes 1985;34(6):553-7.
1985: Sandor Pongor; Michael Brownlee; A Cerami
Carbodiimide-mediated O-sulfation of hydroxy-amino acids and peptides: a reaction suitable for radiolabeling.
Archives of biochemistry and biophysics 1985;238(2):458-63.
1984: Michael Brownlee; H Vlassara; A Cerami
Nonenzymatic glycosylation and the pathogenesis of diabetic complications.
Annals of internal medicine 1984;101(4):527-37.
1984: H Vlassara; Michael Brownlee; A Cerami
Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts.
The Journal of experimental medicine 1984;160(1):197-207.
1984: Michael Brownlee; H Vlassara; A Cerami
Inhibition of heparin-catalyzed human antithrombin III activity by nonenzymatic glycosylation. Possible role in fibrin deposition in diabetes.
Diabetes 1984;33(6):532-5.
1984: Michael Brownlee; H Vlassara; A Cerami; T R Martin; J J Li; K P McAdam
Association of insulin pump therapy with raised serum amyloid A in type I diabetes mellitus.
Lancet 1984;1(8374):411-3.
1983: Sandor Pongor; Michael Brownlee; A Cerami
Preparation of high-potency, non-aggregating insulins using a novel sulfation procedure.
Diabetes 1983;32(12):1087-91.
1983: Michael Brownlee; Sandor Pongor; A Cerami
Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.
The Journal of experimental medicine 1983;158(5):1739-44.
1983: H Vlassara; Michael Brownlee; A Cerami
Excessive nonenzymatic glycosylation of peripheral and central nervous system myelin components in diabetic rats.
Diabetes 1983;32(7):670-4.
1983: Michael Brownlee; H Vlassara; A Cerami
Nonenzymatic glycosylation reduces the susceptibility of fibrin to degradation by plasmin.
Diabetes 1983;32(7):680-4.
1983: Michael Brownlee; A Cerami
Glycosylated insulin complexed to Concanavalin A. Biochemical basis for a closed-loop insulin delivery system.
Diabetes 1983;32(6):499-504.
1982: H Vlassara; Michael Brownlee; A Cerami
Assessment of diabetic control by measurement of urinary glycopeptides.
Diabetologia 1982;23(3):252-4.
1981: H Vlassara; Michael Brownlee; A Cerami
Nonenzymatic glycosylation of peripheral nerve protein in diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(8):5190-2.
1981: Michael Brownlee; A Cerami
The biochemistry of the complications of diabetes mellitus.
Annual review of biochemistry 1981;50():385-432.
1980: Michael Brownlee; H Vlassara; A Cerami
Measurement of glycosylated amino acids and peptides from urine of diabetic patients using affinity chromatography.
Diabetes 1980;29(12):1044-7.
1980: C M Peterson; L B Jovanovic; Michael Brownlee; R L Jones; A Cerami
Closing the loop: practical and theoretical.
Diabetes care 1980;3(2):318-21.
1979: Michael Brownlee; A Cerami
A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin.
Science (New York, N.Y.) 1979;206(4423):1190-1.
1979: Michael Brownlee
Insulin treatment of diabetes.
Hospital practice 1979;14(4):85-94.
1979: Michael Brownlee
Clinical strategy in diabetes mellitus.
Hospital practice 1979;14(2):11, 15.
1979: Michael Brownlee; Robert Spiro
Glomerular basement membrane metabolism in the diabetic rat. In vivo studies.
Diabetes 1979;28(2):121-5.
1979: Michael Brownlee; Robert Spiro
Biochemistry of the basement membrane in diabetes mellitus.
Advances in experimental medicine and biology 1979;124():141-56.
1976: Michael Brownlee
alpha1-Macroglobulin and reduced basement-membrane degradation in diabetes.
Lancet 1976;1(7963):779-80.
1974: Michael Brownlee; S S Kroopf
Letter: Metoclopramide for gastroparesis diabeticorum.
The New England journal of medicine 1974;291(23):1257-8.