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Robert Siliciano

Research Profile

Living Beings

HIV-1

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Highly Active Antiretroviral Therapy

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Publications

TOP 3
Amy F Weil; Yan Zhou; Devlina Ghosh; Moira A McMahon; Lauren Seiple; Robert Siliciano; Adam M Spivak; James T Stivers
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
Susanne Eriksson; Erin H Graf; Frederick Hecht; Rebecca Hoh; Peter Hunt; Rowena Johnston; Jun Lai; Elena S Lysenko; Una O'Doherty; Sarah Palmer; Douglas D Richman; Mohamed Abdel-Mohsen; Ronald J Bosch; Stanley Chioma; Viktor Dahl; Steven G Deeks; Fatemeh Emad; Robert Siliciano; Ma Somsouk; Matthew C Strain; Joseph Wong; Steven A Yukl; Janet D Siliciano
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
Daniela Boehm; James E Bradner; Vincenzo Calvanese; Roy D Dar; Pao-Chen Li; Laura Martins; Vicente Planelles; Sebastian Schroeder; Robert Siliciano; Eric Verdin; Leor Weinberger; Sifei Xing; Ming-Ming Zhou; Katherine Aull; Melanie Ott
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

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All Publications

2013: Amy F Weil; Yan Zhou; Devlina Ghosh; Moira A McMahon; Lauren Seiple; Robert Siliciano; Adam M Spivak; James T Stivers
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):E448-57.
2013: Susanne Eriksson; Erin H Graf; Frederick Hecht; Rebecca Hoh; Peter Hunt; Rowena Johnston; Jun Lai; Elena S Lysenko; Una O'Doherty; Sarah Palmer; Douglas D Richman; Mohamed Abdel-Mohsen; Ronald J Bosch; Stanley Chioma; Viktor Dahl; Steven G Deeks; Fatemeh Emad; Robert Siliciano; Ma Somsouk; Matthew C Strain; Joseph Wong; Steven A Yukl; Janet D Siliciano
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
PLoS pathogens 2013;9(2):e1003174.
2013: Daniela Boehm; James E Bradner; Vincenzo Calvanese; Roy D Dar; Pao-Chen Li; Laura Martins; Vicente Planelles; Sebastian Schroeder; Robert Siliciano; Eric Verdin; Leor Weinberger; Sifei Xing; Ming-Ming Zhou; Katherine Aull; Melanie Ott
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
Cell cycle (Georgetown, Tex.) 2013;12(3):452-62.
2012: Michelle Kim Zinchenko; Robert Siliciano
Editorial: JQ1: giving HIV-1 expression a boost by blocking bromodomains?
Journal of leukocyte biology 2012;92(6):1127-9.
2012: Christine M Durand; Joel N Blankson; Robert Siliciano
Developing strategies for HIV-1 eradication.
Trends in immunology 2012;33(11):554-62.
2012: Kai Deng; Janice E Clements; MARY ZINK; Robert Siliciano
A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential.
Journal of virology 2012;86(20):11368-72.
2012: Evelyn Eisele; Robert Siliciano
Redefining the viral reservoirs that prevent HIV-1 eradication.
Immunity 2012;37(3):377-88.
2012: Daniel I S Rosenbloom; Robert Siliciano; Alison L Hill; S Alireza Rabi; Martin A Nowak
Antiretroviral dynamics determines HIV evolution and predicts therapy outcome.
Nature medicine 2012;18(9):1378-85.
2012: Liang Shan; Neeta S Shroff; Hung-Chih Yang; Hao Zhang; Joel N Blankson; Kai Deng; Christine M Durand; Joseph B Margolick; S Alireza Rabi; Robert Siliciano
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.
Immunity 2012;36(3):491-501.
2012: Daniel E Goldberg; Robert Siliciano; William R Jacobs
Outwitting evolution: fighting drug-resistant TB, malaria, and HIV.
Cell 2012;148(6):1271-83.
2012: Christine M Durand; Evelyn E Eisele; Joel E Gallant; Gabriel Ghiaur; Richard J Jones; Jun F Lai; Joseph B Margolick; S Alireza Rabi; Maria Salgado; Liang Shan; Janet D Siliciano; Richard F Ambinder; Hao Zhang; Robert Siliciano
HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.
The Journal of infectious diseases 2012;205(6):1014-8.
2012: Benjamin L Jilek; Jun Lai; S Alireza Rabi; Maame E Sampah; Lin Shen; Cynthia K Bullen; Melissa Zarr; Robert Siliciano
A quantitative basis for antiretroviral therapy for HIV-1 infection.
Nature medicine 2012;18(3):446-51.
2012: Sifei Xing; Jun O Liu; Neeta S Shroff; Joseph B Margolick; Shridhar Bhat; Joseph A Lopez; Hao Zhang; Robert Siliciano
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
The Journal of antimicrobial chemotherapy 2012;67(2):398-403.
2012: Seema M Thayil; Robert Siliciano; Joel N Blankson; Robert Bollinger; Ya-Chi Ho; Petros C Karakousis; Kathleen R Page
Mycobacterium tuberculosis complex enhances susceptibility of CD4 T cells to HIV through a TLR2-mediated pathway.
PloS one 2012;7(7):e41093.
2012: Robert W Buckheit; Oluwaseun Falade-Nwulia; Joel E Gallant; Sarah Huculak; Karen A O'Connell; Maria Salgado; Robert Siliciano; Thomas M Williams; Tracy G Allen; Angela Alme; Joel N Blankson
Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs.
Nature communications 2012;3():716.
2011: Robert Siliciano
Measurement of antiviral activity in drugs for HIV-1.
The Lancet infectious diseases 2011;11(12):888-9.
2011: Karen A O'Connell; S Alireza Rabi; Robert Siliciano; Joel N Blankson
CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):E689-98.
2011: Robert Siliciano; Warner C Greene
HIV latency.
Cold Spring Harbor perspectives in medicine 2011;1(1):a007096.
2011: Lin Shen; Sifei Xing; Jun Lai; S Alireza Rabi; Ahmad R Sedaghat; Liang Shan; Robert Siliciano
A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs.
Science translational medicine 2011;3(91):91ra63.
2011: Adam M Spivak; Claus O Wilke; Moira A McMahon; S Alireza Rabi; Ahmad R Sedaghat; Liang Shan; Robert Siliciano
Short communication: dynamic constraints on the second phase compartment of HIV-infected cells.
AIDS research and human retroviruses 2011;27(7):759-61.
2011: Sifei Xing; Cynthia K Bullen; Neeta S Shroff; Liang Shan; Hung-Chih Yang; Jordyn L Manucci; Shridhar Bhat; Hao Zhang; Joseph B Margolick; Thomas C Quinn; David M Margolis; Janet D Siliciano; Robert Siliciano
Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
Journal of virology 2011;85(12):6060-4.
2011: Liang Shan; Hung-Chih Yang; S Alireza Rabi; Hector C Bravo; Neeta S Shroff; Rafael A Irizarry; Hao Zhang; Joseph B Margolick; Janet D Siliciano; Robert Siliciano
Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model.
Journal of virology 2011;85(11):5384-93.
2011: Maame Efua S Sampah; Lin Shen; Benjamin L Jilek; Robert Siliciano
Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7613-8.
2011: Moira A McMahon; Teresa Parsons; Lin Shen; Janet D Siliciano; Robert Siliciano
Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses.
Journal of virology 2011;85(9):4618-22.
2011: Maria Salgado; Robert Siliciano; Robert W Buckheit; Justin R Bailey; Autumn R Breaud; Amina A Chaudhry; William Clarke; Joseph B Margolick; Mark A Marzinke; Karen A O'Connell; S Alireza Rabi; Joel N Blankson
Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy.
Retrovirology 2011;8():97.
2011: Karen A O'Connell; Robert Siliciano; Robert W Hegarty; Joel N Blankson
Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor.
Retrovirology 2011;8():63.
2011: S Alireza Rabi; Karen A O'Connell; Daria Nikolaeva; Justin R Bailey; Benjamin L Jilek; Lin Shen; Kathleen R Page; Robert Siliciano; Joel N Blankson
Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection.
Journal of virology 2011;85(2):979-86.
2010: Rahul M Kohli; Robert W Maul; Amy F Guminski; Rhonda L McClure; Kiran S Gajula; Huseyin Saribasak; Moira A McMahon; Robert Siliciano; Patricia J Gearhart; James T Stivers
Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.
The Journal of biological chemistry 2010;285(52):40956-64.
2010: M L Bellows; M S Taylor; Philip A Cole; L Shen; Robert Siliciano; H K Fung; Christodoulos A Floudas
Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework.
Biophysical journal 2010;99(10):3445-53.
2010: Janet D Siliciano; Robert Siliciano
Biomarkers of HIV replication.
Current opinion in HIV and AIDS 2010;5(6):491-7.
2010: Lin Shen; Robert Siliciano
Achieving a quantitative understanding of antiretroviral drug efficacy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(9):1105-6; author reply 1106-7.
2010: H Nina Kim; Jing Wang; James Hughes; Robert Coombs; Jorge Sanchez; Stewart Reid; Sinead Delany-Moretlwe; Frances Cowan; Jonathan Fuchs; Susan H Eshleman; Leila Khaki; Moira A McMahon; Robert Siliciano; Anna Wald; Connie Celum
Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.
The Journal of infectious diseases 2010;202(5):734-8.
2010: Robert Siliciano
What do we need to do to cure HIV infection.
Topics in HIV medicine : a publication of the International AIDS Society, USA 2010;18(3):104-8.
2010: Karen A O'Connell; Timothy P Brennan; Justin R Bailey; Stuart C Ray; Robert Siliciano; Joel N Blankson
Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.
Journal of virology 2010;84(14):7018-28.
2010: Adam M Spivak; Robert Siliciano
Using highly active antiretroviral therapy to decrease perioperative HIV-1 transmission risk.
AIDS (London, England) 2010;24(10):1603-404; author reply 1604.
2010: Gregory L Szeto; Angela K Brice; Hung-Chih Yang; Sheila A. Barber; Robert Siliciano; Janice E Clements
Minocycline attenuates HIV infection and reactivation by suppressing cellular activation in human CD4+ T cells.
The Journal of infectious diseases 2010;201(8):1132-40.
2010: Adam M Spivak; Tim P Brennan; Karen A O'Connell; Emily Sydnor; Thomas M Williams; Robert Siliciano; Joel E Gallant; Joel N Blankson
A case of seronegative HIV-1 infection.
The Journal of infectious diseases 2010;201(3):341-5.
2010: Moira A McMahon; Janet D Siliciano; Rahul Kohli; Robert Siliciano
Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.
AIDS (London, England) 2010;24(2):319-23.
2010: Rajesh T Gandhi; Ronald J Bosch; Evgenia Aga; Mary Albrecht; Lisa M Demeter; Carrie Dykes; Barbara Bastow; Michael Para; Jun Lai; Robert Siliciano; Janet D Siliciano; Joseph J Eron
No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy.
The Journal of infectious diseases 2010;201(2):293-6.
2010: Maria Salgado; Timothy P Brennan; Karen A O'Connell; Justin R Bailey; Stuart C Ray; Robert Siliciano; Joel N Blankson
Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors.
Retrovirology 2010;7():94.
2010: Terrence M Dobrowsky; Brian R Daniels; Robert Siliciano; Sean X Sun; Denis Wirtz
Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion.
PLoS computational biology 2010;6(7):e1000855.
2009: Karen A O'Connell; Jie Xu; Anna P Durbin; LINDA APUZZO; Hejab Imteyaz; Thomas M Williams; Stuart C Ray; Joseph B Margolick; Robert Siliciano; Joel N Blankson
HIV-1 evolution following transmission to an HLA-B*5801-positive patient.
The Journal of infectious diseases 2009;200(12):1820-4.
2009: Moira A McMahon; Lin Shen; Robert Siliciano
New approaches for quantitating the inhibition of HIV-1 replication by antiviral drugs in vitro and in vivo.
Current opinion in infectious diseases 2009;22(6):574-82.
2009: Lin Shen; S Alireza Rabi; Robert Siliciano
A novel method for determining the inhibitory potential of anti-HIV drugs.
Trends in pharmacological sciences 2009;30(12):610-6.
2009: Hung-Chih Yang; Sifei Xing; Liang Shan; Karen O'Connell; Jason Dinoso; Anding Shen; Yan Zhou; Cynthia K Shrum; Yefei Han; Jun O Liu; Hao Zhang; Joseph B Margolick; Robert Siliciano
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation.
The Journal of clinical investigation 2009;119(11):3473-86.
2009: Jason B Dinoso; S Alireza Rabi; Joel N Blankson; Lucio Gama; Joseph L Mankowski; Robert Siliciano; MARY ZINK; Janice E Clements
A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy.
Journal of virology 2009;83(18):9247-57.
2009: Timothy P Brennan; John O Woods; Ahmad R Sedaghat; Janet D Siliciano; Robert Siliciano; Claus O Wilke
Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy.
Journal of virology 2009;83(17):8470-81.
2009: Jason B Dinoso; S Y Kim; A M Wiegand; S E Palmer; Stephen J Gange; L Cranmer; A O'Shea; M Callender; A Spivak; T Brennan; M F Kearney; M A Proschan; J M Mican; C A Rehm; John M Coffin; J W Mellors; Robert Siliciano; F Maldarelli
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9403-8.
2009: Megan Wind-Rotolo; Christine Durand; Lisa Cranmer; Alison Reid; Neil A Martinson; Meg C Doherty; Benjamin L Jilek; Joseph Kagaayi; Allan Kizza; Visva Pillay; Oliver Laeyendecker; Steven J Reynolds; Susan H Eshleman; Bryan Lau; Stuart C Ray; Janet D Siliciano; Thomas C Quinn; Robert Siliciano
Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.
The Journal of infectious diseases 2009;199(9):1301-9.
2009: Karen A O'Connell; Yefei Han; Thomas M Williams; Robert Siliciano; Joel N Blankson
Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro.
Journal of virology 2009;83(10):5028-34.
2009: Hung-Chih Yang; Lin Shen; Robert Siliciano; JOEL POMERANTZ
Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6321-6.
2009: Kara G Lassen; Michael A Lobritz; Justin R Bailey; Samantha Johnston; Sandra Nguyen; Benhur Lee; Tom Chou; Robert Siliciano; Martin Markowitz; Eric J Arts
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
PLoS pathogens 2009;5(4):e1000377.
2009: Ahmad R Sedaghat; Robert Siliciano; Claus O Wilke
Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir.
Antiviral therapy 2009;14(2):263-71.
2009: Justin R Bailey; Timothy P Brennan; Karen A O'Connell; Robert Siliciano; Joel N Blankson
Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors.
Journal of virology 2009;83(1):88-97.
2008: Joel N Blankson; Robert Siliciano
Elite suppression of HIV-1 replication.
Immunity 2008;29(6):845-7.
2008: Moira A McMahon; Janet D Siliciano; Jun Lai; Jun O Liu; James T Stivers; Robert Siliciano; Rahul Kohli
The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation.
The Journal of biological chemistry 2008;283(46):31289-93.
2008: Karen O'Connell; Robert Siliciano
Immune alteration fends off AIDS.
Nature medicine 2008;14(10):1016-8.
2008: Yan Zhou; Lin Shen; Hung-Chih Yang; Robert Siliciano
Preferential cytolysis of peripheral memory CD4+ T cells by in vitro X4-tropic human immunodeficiency virus type 1 infection before the completion of reverse transcription.
Journal of virology 2008;82(18):9154-63.
2008: Amanda J Chase; Hung-Chih Yang; Hao Zhang; Joel N Blankson; Robert Siliciano
Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation.
Journal of virology 2008;82(17):8307-15.
2008: Yefei Han; Yijie B Lin; Wenfeng An; Jie Xu; Hung-Chih Yang; Karen O'Connell; Dominic Dordai; Jef Boeke; Janet D Siliciano; Robert Siliciano
Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough.
Cell host & microbe 2008;4(2):134-46.
2008: Justin R Bailey; Karen O'Connell; Hung-Chih Yang; Yefei Han; Jie Xu; Benjamin Jilek; Thomas M Williams; Stuart C Ray; Robert Siliciano; Joel N Blankson
Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor.
Journal of virology 2008;82(15):7395-410.
2008: Lin Shen; Robert Siliciano
Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection.
The Journal of allergy and clinical immunology 2008;122(1):22-8.
2008: Lin Shen; Susan Peterson; Ahmad R Sedaghat; Moira A McMahon; Marc Callender; Haili Zhang; Yan Zhou; Eleanor Pitt; Karen S Anderson; Edward P Acosta; Robert Siliciano
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs.
Nature medicine 2008;14(7):762-6.
2008: Jason B Dinoso; Scott Y Kim; Robert Siliciano; Joel N Blankson
A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(1):102-4.
2008: Terrence M Dobrowsky; Yan Zhou; Sean X Sun; Robert Siliciano; Denis Wirtz
Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution.
Journal of virology 2008;82(14):7022-33.
2008: Rabih Halwani; Jean D Boyer; Bader Yassine-Diab; Elias K Haddad; Tara M Robinson; Sanjeev Kumar; Rose Parkinson; Ling Wu; Maninder K Sidhu; Rebecca Phillipson-Weiner; George Pavlakis; Barbara K Felber; Mark G Lewis; Anding Shen; Robert Siliciano; David B Weiner; Rafick-Pierre Sekaly
Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7969-79.
2008: Joe Sasadeusz; Jennifer Audsley; Anne Mijch; Rachel Baden; Jose Caro; Hermeyone Hunter; Gail Matthews; Moira A McMahon; Susan A Olender; Robert Siliciano; Sharon R Lewin; Chloe L Thio
The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients.
AIDS (London, England) 2008;22(8):947-55.
2008: Ahmad R Sedaghat; Jason B Dinoso; Lin Shen; Claus O Wilke; Robert Siliciano
Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4832-7.
2008: Shiv K Gandhi; Janet D Siliciano; Justin R Bailey; Robert Siliciano; Joel N Blankson
Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors.
Journal of virology 2008;82(6):3125-30.
2008: Robert A Domaoal; Moira McMahon; Chloe L Thio; Christopher M Bailey; Julian Tirado-Rives; Aleksander Obikhod; Mervi Detorio; Kimberly L Rapp; Robert Siliciano; Ray F Schinazi; Karen S Anderson
Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.
The Journal of biological chemistry 2008;283(9):5452-9.
2008: Yefei Han; Jun Lai; PATRICIA CROVO; Joel E Gallant; Thomas M Williams; Robert Siliciano; Joel N Blankson
The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors.
AIDS (London, England) 2008;22(4):541-4.
2008: Ahmad R Sedaghat; Jennifer German; Tanya M Teslovich; Joseph Cofrancesco; Chunfa Jie; C Conover Talbot; Robert Siliciano
Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics.
Journal of virology 2008;82(4):1870-83.
2008: Ahmad R Sedaghat; Robert Siliciano; Claus O Wilke
Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART.
BMC infectious diseases 2008;8():2.
2007: Amanda J Chase; Ahmad R Sedaghat; Jennifer R German; Lucio Gama; MARY ZINK; Janice E Clements; Robert Siliciano
Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection.
Journal of virology 2007;81(23):12748-57.
2007: Yefei Han; Robert Siliciano
Keeping quiet: microRNAs in HIV-1 latency.
Nature medicine 2007;13(10):1138-40.
2007: Ahmad R Sedaghat; Janet D Siliciano; Timothy P Brennan; Claus O Wilke; Robert Siliciano
Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART.
PLoS pathogens 2007;3(8):e122.
2007: Justin R Bailey; Haili Zhang; Barbara W Wegweiser; Hung-Chih Yang; Laura Herrera; Aima Ahonkhai; Thomas M Williams; Robert Siliciano; Joel N Blankson
Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.
The Journal of infectious diseases 2007;196(1):50-5.
2007: Moira A McMahon; Benjamin L Jilek; Timothy P Brennan; Lin Shen; Yan Zhou; Megan Wind-Rotolo; Sifei Xing; Shridhar Bhat; Braden Hale; Robert Hegarty; Curtis R Chong; Jun O Liu; Robert Siliciano; Chloe L Thio
The HBV drug entecavir - effects on HIV-1 replication and resistance.
The New England journal of medicine 2007;356(25):2614-21.
2007: Janet D Siliciano; Jun Lai; Marc Callender; Eleanor Pitt; Hao Zhang; Joseph B Margolick; Joel E Gallant; Joseph Cofrancesco; Richard D Moore; Stephen J Gange; Robert Siliciano
Stability of the latent reservoir for HIV-1 in patients receiving valproic acid.
The Journal of infectious diseases 2007;195(6):833-6.
2007: Joel N Blankson; Justin R Bailey; Seema Thayil; Hung-Chih Yang; Kara G Lassen; Jun Lai; Shiv K Gandhi; Janet D Siliciano; Thomas M Williams; Robert Siliciano
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.
Journal of virology 2007;81(5):2508-18.
2007: Yefei Han; Megan Wind-Rotolo; Hung-Chih Yang; Janet D Siliciano; Robert Siliciano
Experimental approaches to the study of HIV-1 latency.
Nature reviews. Microbiology 2007;5(2):95-106.
2007: Anding Shen; Hung-Chih Yang; Yan Zhou; Amanda J Chase; Jean D Boyer; Hao Zhang; Joseph B Margolick; MARY ZINK; Janice E Clements; Robert Siliciano
Novel pathway for induction of latent virus from resting CD4(+) T cells in the simian immunodeficiency virus/macaque model of human immunodeficiency virus type 1 latency.
Journal of virology 2007;81(4):1660-70.
2007: Susan Peterson; Alison P Reid; Scott Kim; Robert Siliciano
Treatment implications of the latent reservoir for HIV-1.
Advances in pharmacology (San Diego, Calif.) 2007;55():411-25.
2006: Kara G Lassen; Kasra X Ramyar; Justin R Bailey; Yan Zhou; Robert Siliciano
Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.
PLoS pathogens 2006;2(7):e68.
2006: Justin R Bailey; Ahmad R Sedaghat; Tara L Kieffer; Timothy Brennan; Patricia K Lee; Megan Wind-Rotolo; Christine M Haggerty; Ashrit R Kamireddi; Yi Liu; Jessica Lee; Deborah Persaud; Joel E Gallant; Joseph Cofrancesco; Thomas C Quinn; Claus O Wilke; Stuart C Ray; Janet D Siliciano; Richard E Nettles; Robert Siliciano
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.
Journal of virology 2006;80(13):6441-57.
2006: Justin R Bailey; Thomas M Williams; Robert Siliciano; Joel N Blankson
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.
The Journal of experimental medicine 2006;203(5):1357-69.
2006: Justin R Bailey; Kara G Lassen; Hung-Chih Yang; Thomas C Quinn; Stuart C Ray; Joel N Blankson; Robert Siliciano
Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy.
Journal of virology 2006;80(10):4758-70.
2006: Patricia K Lee; Tara L Kieffer; Robert Siliciano; Richard E Nettles
HIV-1 viral load blips are of limited clinical significance.
The Journal of antimicrobial chemotherapy 2006;57(5):803-5.
2006: Richard E Nettles; Tara L Kieffer; Teresa Parsons; James Johnson; Joseph Cofrancesco; Joel E Gallant; Kathryn Carson; Robert Siliciano; Charles Flexner
Marked intraindividual variability in antiretroviral concentrations may limit the utility of therapeutic drug monitoring.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(8):1189-96.
2006: Janet D Siliciano; Robert Siliciano
The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure.
Current opinion in HIV and AIDS 2006;1(2):121-8.
2006: Joel N Blankson; Justin R Bailey; Robert Siliciano
Crosscurrents in HIV-1 evolution.
Nature immunology 2006;7(2):121-2.
2006: Christine M Haggerty; Eleanor Pitt; Robert Siliciano
The latent reservoir for HIV-1 in resting CD4+ T cells and other viral reservoirs during chronic infection: insights from treatment and treatment-interruption trials.
Current opinion in HIV and AIDS 2006;1(1):62-8.
2006: Amanda Chase; Yan Zhou; Robert Siliciano
HIV-1-induced depletion of CD4+ T cells in the gut: mechanism and therapeutic implications.
Trends in pharmacological sciences 2006;27(1):4-7.
2005: Richard E Nettles; Tara L Keiffer; Joseph Cofrancesco; Joel E Gallant; Thomas C Quinn; J Brooks Jackson; Charles Flexner; Kathryn Carson; Albert W Wu; Robert Siliciano
Psychological distress and physical pain appear to have no short-term adverse impact on plasma HIV-1 RNA levels in patients on successful HAART.
HIV clinical trials 2005;6(5):262-71.
2005: Janet D Siliciano; Robert Siliciano
Targeting HIV reservoirs with valproic acid.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 2005;17(5):8-9.
2005: Robert Siliciano
Scientific rationale for antiretroviral therapy in 2005: viral reservoirs and resistance evolution.
Topics in HIV medicine : a publication of the International AIDS Society, USA 2005;13(3):96-100.
2005: Lucy Minnich Carruth; MARY ZINK; Patrick M Tarwater; Michael D Miller; Ming Li; Laurie A Queen; Joseph L Mankowski; Anding Shen; Robert Siliciano; Janice E Clements
SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy.
Journal of medical primatology 2005;34(3):109-21.
2005: Joel N Blankson; Janet D Siliciano; Robert Siliciano
The Effect of early treatment on the latent reservoir of HIV-1.
The Journal of infectious diseases 2005;191(9):1394-6.
2005: Daphne Monie; Rachel P Simmons; Richard E Nettles; Tara L Kieffer; Yan Zhou; Haili Zhang; Sharon Karmon; Roxann G Ingersoll; Karen Chadwick; Hao Zhang; Joseph B Margolick; Thomas C Quinn; Stuart C Ray; Megan Wind-Rotolo; Michael Miller; Deborah Persaud; Robert Siliciano
A novel assay allows genotyping of the latent reservoir for human immunodeficiency virus type 1 in the resting CD4+ T cells of viremic patients.
Journal of virology 2005;79(8):5185-202.
2005: Jean D Boyer; Tara M Robinson; Paulo Cesar Maciag; Xiaohui Peng; Ross S Johnson; George Pavlakis; Mark G Lewis; Anding Shen; Robert Siliciano; Charles R Brown; David B Weiner; Yvonne Paterson
DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication.
Virology 2005;333(1):88-101.
2005: Richard E Nettles; Tara L Kieffer; Patty Kwon; Daphne Monie; Yefei Han; Teresa Parsons; Joseph Cofrancesco; Joel E Gallant; Thomas C Quinn; J Brooks Jackson; Charles Flexner; Kathryn Carson; Stuart C Ray; Deborah Persaud; Robert Siliciano
Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART.
JAMA : the journal of the American Medical Association 2005;293(7):817-29.
2005: Yan Zhou; Haili Zhang; Janet D Siliciano; Robert Siliciano
Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells.
Journal of virology 2005;79(4):2199-210.
2005: Tara L Kieffer; Patty Kwon; Richard E Nettles; Yefei Han; Stuart C Ray; Robert Siliciano
G-->A hypermutation in protease and reverse transcriptase regions of human immunodeficiency virus type 1 residing in resting CD4+ T cells in vivo.
Journal of virology 2005;79(3):1975-80.
2005: S B Justin Wong; Robert Siliciano
Contribution of virus-like particles to the immunogenicity of human immunodeficiency virus type 1 Gag-derived vaccines in mice.
Journal of virology 2005;79(3):1701-12.
2005: Janet D Siliciano; Robert Siliciano
Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals.
Methods in molecular biology (Clifton, N.J.) 2005;304():3-15.
2004: Kara G Lassen; Yefei Han; Yan Zhou; Janet D Siliciano; Robert Siliciano
The multifactorial nature of HIV-1 latency.
Trends in molecular medicine 2004;10(11):525-31.
2004: Richard E Nettles; Tara L Kieffer; Rachel P Simmons; Joseph Cofrancesco; Richard D Moore; Joel E Gallant; Deborah Persaud; Robert Siliciano
Genotypic resistance in HIV-1-infected patients with persistently detectable low-level viremia while receiving highly active antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(7):1030-7.
2004: S B Justin Wong; Christopher B Buck; Xuefei Shen; Robert Siliciano
An evaluation of enforced rapid proteasomal degradation as a means of enhancing vaccine-induced CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3073-83.
2004: Kara G Lassen; Justin R Bailey; Robert Siliciano
Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo.
Journal of virology 2004;78(17):9105-14.
2004: Rachel Simmons; Robert Siliciano
Can antiretroviral therapy ever be stopped? An update.
The AIDS reader 2004;14(8):435-8, 441-2.
2004: Justin Bailey; Joel N Blankson; Megan Wind-Rotolo; Robert Siliciano
Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs.
Current opinion in immunology 2004;16(4):470-6.
2004: Zhongde Wang; Corinna La Rosa; Shahram Mekhoubad; Simon F Lacey; Maria Villacres; Susan Markel; Jeff Longmate; Joshua D I Ellenhorn; Robert Siliciano; Christopher Buck; William J Britt; Don J Diamond
Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells.
Blood 2004;104(3):847-56.
2004: Tara Kieffer; Robert Siliciano
Averting the evolution of drug resistance.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 2004;16(4):9-10.
2004: Janet D Siliciano; Robert Siliciano
A long-term latent reservoir for HIV-1: discovery and clinical implications.
The Journal of antimicrobial chemotherapy 2004;54(1):6-9.
2004: Yefei Han; Kara G Lassen; Daphne Monie; Ahmad R Sedaghat; Shino Shimoji; Xiao Liu; Theodore C Pierson; Joseph B Margolick; Robert Siliciano; Janet D Siliciano
Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.
Journal of virology 2004;78(12):6122-33.
2004: Tara L Kieffer; Mariel M Finucane; Richard E Nettles; Thomas C Quinn; Karl W Broman; Stuart C Ray; Deborah Persaud; Robert Siliciano
Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads.
The Journal of infectious diseases 2004;189(8):1452-65.
2004: Haili Zhang; Yan Zhou; Cecily Alcock; Tara Kiefer; Daphne Monie; Janet D Siliciano; Quan Li; Paul A Pham; Joseph Cofrancesco; Deborah Persaud; Robert Siliciano
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.
Journal of virology 2004;78(4):1718-29.
2004: Deborah Persaud; George K Siberry; Aima Ahonkhai; Joleen Kajdas; Daphne Monie; Nancy Hutton; Douglas C Watson; Thomas C Quinn; Stuart C Ray; Robert Siliciano
Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads.
Journal of virology 2004;78(2):968-79.
2003: Malini Mansharamani; David Raymond Graham; Daphne Monie; Kenneth K Lee; James E K Hildreth; Robert Siliciano; Katherine L Wilson
Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions.
Journal of virology 2003;77(24):13084-92.
2003: Pirouz Daftarian; Saima Ali; Rahul Sharan; Simon F Lacey; Corinna La Rosa; Jeff Longmate; Christopher Buck; Robert Siliciano; Don J Diamond
Immunization with Th-CTL fusion peptide and cytosine-phosphate-guanine DNA in transgenic HLA-A2 mice induces recognition of HIV-infected T cells and clears vaccinia virus challenge.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4028-39.
2003: Monika Hermankova; Janet D Siliciano; Yan Zhou; Daphne Monie; Karen Chadwick; Joseph B Margolick; Thomas C Quinn; Robert Siliciano
Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo.
Journal of virology 2003;77(13):7383-92.
2003: Janet D Siliciano; Joleen Kajdas; Diana Finzi; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Colin Kovacs; Stephen J Gange; Robert Siliciano
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.
Nature medicine 2003;9(6):727-8.
2003: Anding Shen; MARY ZINK; Joseph L Mankowski; Karen Chadwick; Joseph B Margolick; Lucy Minnich Carruth; Ming Li; Janice E Clements; Robert Siliciano
Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy.
Journal of virology 2003;77(8):4938-49.
2003: Deborah Persaud; Yan Zhou; Janet D Siliciano; Robert Siliciano
Latency in human immunodeficiency virus type 1 infection: no easy answers.
Journal of virology 2003;77(3):1659-65.
2002: Xuefei Shen; S B Justin Wong; Christopher B Buck; Jiangwen Zhang; Robert Siliciano
Direct priming and cross-priming contribute differentially to the induction of CD8+ CTL following exposure to vaccinia virus via different routes.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4222-9.
2002: Christian T Ruff; Stuart C Ray; Patty Kwon; Rebekah Zinn; Amanda R Pendleton; Nancy Hutton; Roxann Ashworth; Stephen J Gange; Thomas C Quinn; Robert Siliciano; Deborah Persaud
Persistence of wild-type virus and lack of temporal structure in the latent reservoir for human immunodeficiency virus type 1 in pediatric patients with extensive antiretroviral exposure.
Journal of virology 2002;76(18):9481-92.
2002: Theodore C Pierson; Yan Zhou; Tara L Kieffer; Christian T Ruff; Christopher Buck; Robert Siliciano
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection.
Journal of virology 2002;76(17):8518-31.
2002: Joel N Blankson; Joel E Gallant; Thomas C Quinn; John G Bartlett; Robert Siliciano
Loss of HIV-1-specific immunity during treatment interruption in 2 chronically infected patients.
JAMA : the journal of the American Medical Association 2002;288(2):162-4.
2002: Theodore C Pierson; Tara L Kieffer; Christian T Ruff; Christopher Buck; Stephen J Gange; Robert Siliciano
Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication.
Journal of virology 2002;76(8):4138-44.
2002: Jesús Saavedra-Lozano; Cynthia McCoig; Jinbo Xu; Yanying Cao; Philip Keiser; Victor Ghetie; Robert Siliciano; Janet D Siliciano; Louis J Picker; Octavio Ramilo; Ellen S Vitetta
An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons.
The Journal of infectious diseases 2002;185(3):306-14.
2002: Joel N Blankson; Deborah Persaud; Robert Siliciano
The challenge of viral reservoirs in HIV-1 infection.
Annual review of medicine 2002;53():557-93.
2001: Monika Hermankova; Stuart C Ray; Christian T Ruff; M Powell-Davis; Roxann G Ingersoll; R T D'Aquila; Thomas C Quinn; Janet D Siliciano; Robert Siliciano; Deborah Persaud
HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy.
JAMA : the journal of the American Medical Association 2001;286(2):196-207.
2001: Joel N Blankson; Robert Siliciano
MHC class II genotype and the control of viremia in HIV-1-infected individuals on highly active antiretroviral therapy.
The Journal of clinical investigation 2001;107(5):549-51.
2001: Joel N Blankson; Joel E Gallant; Robert Siliciano
Proliferative responses to human immunodeficiency virus type 1 (HIV-1) antigens in HIV-1-infected patients with immune reconstitution.
The Journal of infectious diseases 2001;183(4):657-61.
2001: Joel N Blankson; Robert Siliciano
Structured therapeutic interruptions: a review.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 2001;13(1):1, 8-9, 13.
2001: Christopher Buck; X Shen; M A Egan; Theodore C Pierson; C M Walker; Robert Siliciano
The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site.
Journal of virology 2001;75(1):181-91.
2000: Anding Shen; Janet D Siliciano; Theodore C Pierson; Christopher Buck; Robert Siliciano
Establishment of latent HIV-1 infection of resting CD4(+) T lymphocytes does not require inactivation of Vpr.
Virology 2000;278(1):227-33.
2000: K Gupta; D Ott; T J Hope; Robert Siliciano; Jef Boeke
A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions.
Journal of virology 2000;74(24):11811-24.
2000: Joel N Blankson; Diana Finzi; Theodore C Pierson; Beulah P Sabundayo; Karen Chadwick; Joseph B Margolick; Thomas C Quinn; Robert Siliciano
Biphasic decay of latently infected CD4+ T cells in acute human immunodeficiency virus type 1 infection.
The Journal of infectious diseases 2000;182(6):1636-42.
2000: X Shen; Robert Siliciano
Preventing AIDS but not HIV-1 infection with a DNA vaccine.
Science (New York, N.Y.) 2000;290(5491):463-5.
2000: Janet D Siliciano; Robert Siliciano
Latency and viral persistence in HIV-1 infection.
The Journal of clinical investigation 2000;106(7):823-5.
2000: Javier Martinez-Picado; M P DePasquale; N Kartsonis; George J Hanna; Joseph Wong; D Finzi; E Rosenberg; H F Gunthard; Lorraine Sutton; AV Savara; C J Petropoulos; N Hellmann; Bruce D Walker; Douglas D Richman; Robert Siliciano; Richard T D'Aquila
Antiretroviral resistance during successful therapy of HIV type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10948-53.
2000: Theodore C Pierson; Trevor L Hoffman; Joel N Blankson; Diana Finzi; Karen Chadwick; Joseph B Margolick; Christopher Buck; Janet D Siliciano; R W Doms; Robert Siliciano
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.
Journal of virology 2000;74(17):7824-33.
2000: Joel N Blankson; Robert Siliciano
Interleukin 2 treatment for HIV infection.
JAMA : the journal of the American Medical Association 2000;284(2):236-8.
2000: Diana Finzi; Robert Siliciano
Taking aim at HIV replication.
Nature medicine 2000;6(7):735-6.
2000: Robert Siliciano
Can antiretroviral therapy ever be stopped?
The AIDS reader 2000;10(4):224-9.
2000: Deborah Persaud; Theodore C Pierson; Christian T Ruff; Diana Finzi; Karen Chadwick; Joseph B Margolick; ANDREA RUFF; Nancy Hutton; Stuart C Ray; Robert Siliciano
A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children.
The Journal of clinical investigation 2000;105(7):995-1003.
2000: Theodore C Pierson; justin charles mcarthur; Robert Siliciano
Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.
Annual review of immunology 2000;18():665-708.
1999: Franco Lori; Heiko Jessen; Judy Lieberman; Diana Finzi; E Rosenberg; Carmine Tinelli; B Walker; Robert Siliciano; Julianna Lisziewicz
Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir.
The Journal of infectious diseases 1999;180(6):1827-32.
1999: Lucy Minnich Carruth; Tim F Greten; C E Murray; M G Castro; S N Crone; W Pavlat; Jonathan P Schneck; Robert Siliciano
An algorithm for evaluating human cytotoxic T lymphocyte responses to candidate AIDS vaccines.
AIDS research and human retroviruses 1999;15(11):1021-34.
1999: Robert Siliciano
HARRT for life.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 1999;11(4):2.
1999: Julianna Lisziewicz; E Rosenberg; Judy Lieberman; Heiko Jessen; Lucia Lopalco; Robert Siliciano; B Walker; Franco Lori
Control of HIV despite the discontinuation of antiretroviral therapy.
The New England journal of medicine 1999;340(21):1683-4.
1999: Diana Finzi; Joel N Blankson; Janet D Siliciano; Joseph B Margolick; Karen Chadwick; Theodore C Pierson; K Smith; Julianna Lisziewicz; F Lori; Charles Flexner; Thomas C Quinn; Richard E Chaisson; E Rosenberg; B Walker; Stephen J Gange; Joel E Gallant; Robert Siliciano
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Nature medicine 1999;5(5):512-7.
1999: Joel N Blankson; Deborah Persaud; Robert Siliciano
Latent reservoirs for HIV-1.
Current opinion in infectious diseases 1999;12(1):5-11.
1999: R L Ferris; C Hall; NV Sipsas; J T Safrit; Alicja Trocha; R A Koup; R Paul Johnson; Robert Siliciano
Processing of HIV-1 envelope glycoprotein for class I-restricted recognition: dependence on TAP1/2 and mechanisms for cytosolic localization.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1324-32.
1999: T Tobery; Robert Siliciano
Cutting edge: induction of enhanced CTL-dependent protective immunity in vivo by N-end rule targeting of a model tumor antigen.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):639-42.
1999: Robert Siliciano
Latency and reservoirs for HIV-1.
AIDS (London, England) 1999;13 Suppl A():S49-58.
1998: C E Contreras; I N Ploton; Robert Siliciano; C L Karp; Raphael P Viscidi; Nirbhay Kumar
Mapping of specific and promiscuous HLA-DR-restricted T-cell epitopes on the Plasmodium falciparum 27-kilodalton sexual stage-specific antigen.
Infection and immunity 1998;66(8):3579-90.
1998: Julianna Lisziewicz; Heiko Jessen; Diana Finzi; Robert Siliciano; Franco Lori
HIV-1 suppression by early treatment with hydroxyurea, didanosine, and a protease inhibitor.
Lancet 1998;352(9123):199-200.
1998: Diana Finzi; Robert Siliciano
Viral dynamics in HIV-1 infection.
Cell 1998;93(5):665-71.
1998: Mary Lou Clements-Mann; Kent J Weinhold; TJ Matthews; Barney S Graham; Geoffrey J Gorse; Michael C Keefer; M Juliana McElrath; RH Hsieh; Jiri Mestecky; Susan Zolla-Pazner; J Mascola; David H Schwartz; Robert Siliciano; Lawrence Corey; Peter F Wright; Robert B Belshe; Raphael Dolin; S Jackson; S Xu; Patricia Fast; MC Walker; Donald Stablein; Jean-Louis Excler; Jim Tartaglia; E Paoletti
Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1MN gp120, HIV-1SF2 recombinant gp120, or both vaccines in seronegative adults. NIAID AIDS Vaccine Evaluation Group.
The Journal of infectious diseases 1998;177(5):1230-46.
1998: Robert Siliciano
A reservoir for HIV in patients on combination antiretroviral therapy.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 1998;10(1):1, 5-6, 11.
1998: R Paul Johnson; Robert Siliciano; M J McElrath
Cellular immune responses to HIV-1.
AIDS (London, England) 1998;12 Suppl A():S113-20.
1998: Stuart C Ray; Ndongala M Lubaki; B R Dhruva; Robert Siliciano; Robert Bollinger
Autologous strain-specific cytolytic T lymphocyte responses directed against human immunodeficiency virus type 1 Env.
AIDS research and human retroviruses 1998;14(1):3-13.
1997: Diana Finzi; Monika Hermankova; Theodore C Pierson; Lucy Minnich Carruth; Christopher Buck; Richard E Chaisson; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Ron Brookmeyer; Joel E Gallant; M Markowitz; D D Ho; D D Richman; Robert Siliciano
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.
Science (New York, N.Y.) 1997;278(5341):1295-300.
1997: R Ehret; Martin Heinkelein; Robert Siliciano; Christian Jassoy
Human immunodeficiency virus glycoprotein-specific CD4+ cytotoxic T lymphocytes are involved in two types of cytotoxicity: antigen-specific and cell-cell fusion-related cell lysis.
AIDS research and human retroviruses 1997;13(12):1017-21.
1997: Ndongala M Lubaki; Stuart C Ray; B Dhruva; Thomas C Quinn; Robert Siliciano; Robert Bollinger
Characterization of a polyclonal cytolytic T lymphocyte response to human immunodeficiency virus in persons without clinical progression.
The Journal of infectious diseases 1997;175(6):1360-7.
1997: T W Chun; Karen Chadwick; Joseph B Margolick; Robert Siliciano
Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI.
Journal of virology 1997;71(6):4436-44.
1997: T W Chun; Lucy Minnich Carruth; Diana Finzi; X Shen; Joseph A DiGiuseppe; H Taylor; Monika Hermankova; Karen Chadwick; Joseph B Margolick; Thomas C Quinn; Y H Kuo; Ron Brookmeyer; Martha A Zeiger; PATRICIA CROVO; Robert Siliciano
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.
Nature 1997;387(6629):183-8.
1997: A L Ruff; F G Guarnieri; K Staveley-O'Carroll; Robert Siliciano; Thomas J August
The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
The Journal of biological chemistry 1997;272(13):8671-8.
1997: T W Tobery; Robert Siliciano
Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization.
The Journal of experimental medicine 1997;185(5):909-20.
1997: M Juliana McElrath; Robert Siliciano; Kent J Weinhold
HIV type 1 vaccine-induced cytotoxic T cell responses in phase I clinical trials: detection, characterization, and quantitation.
AIDS research and human retroviruses 1997;13(3):211-6.
1997: M A Egan; Lucy Minnich Carruth; J F Rowell; XIAOFANG YU; Robert Siliciano
The ins and outs of HIV endocytosis.
Trends in cell biology 1997;7(2):49.
1997: A Y Liu; B S Torchia; Barbara R Migeon; Robert Siliciano
The human NTT gene: identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4+ T cells.
Genomics 1997;39(2):171-84.
1996: M A Egan; Lucy Minnich Carruth; J F Rowell; XIAOFANG YU; Robert Siliciano
Human immunodeficiency virus type 1 envelope protein endocytosis mediated by a highly conserved intrinsic internalization signal in the cytoplasmic domain of gp41 is suppressed in the presence of the Pr55gag precursor protein.
Journal of virology 1996;70(10):6547-56.
1996: R L Ferris; C Buck; Scott A Hammond; Amina S Woods; Robert J Cotter; M Takiguchi; Y Igarashi; Y Ichikawa; Robert Siliciano
Class I-restricted presentation of an HIV-1 gp41 epitope containing an N-linked glycosylation site. Implications for the mechanism of processing of viral envelope proteins.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):834-40.
1996: Robert Bollinger; M A Egan; T W Chun; B Mathieson; Robert Siliciano
Cellular immune responses to HIV-1 in progressive and non-progressive infections.
AIDS (London, England) 1996;10 Suppl A():S85-96.
1996: Robert Siliciano
The role of CD4 in HIV envelope-mediated pathogenesis.
Current topics in microbiology and immunology 1996;205():159-79.
1995: T W Chun; Diana Finzi; Joseph B Margolick; Karen Chadwick; David H Schwartz; Robert Siliciano
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.
Nature medicine 1995;1(12):1284-90.
1995: J F Rowell; A L Ruff; F G Guarnieri; K Staveley-O'Carroll; Xinli Lin; J Tang; Thomas J August; Robert Siliciano
Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1818-28.
1995: J F Rowell; P E Stanhope; Robert Siliciano
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):473-88.
1995: Robert Siliciano; Mark J Soloski
MHC class I-restricted processing of transmembrane proteins. Mechanism and biologic significance.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):2-5.
1995: M A Egan; W A Pavlat; J Tartaglia; E Paoletti; K J Weinhold; M L Clements; Robert Siliciano
Induction of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T lymphocyte responses in seronegative adults by a nonreplicating, host-range-restricted canarypox vector (ALVAC) carrying the HIV-1MN env gene.
The Journal of infectious diseases 1995;171(6):1623-7.
1995: Scott A Hammond; R Paul Johnson; S A Kalams; Bruce D Walker; M Takiguchi; J T Safrit; RA Koup; Robert Siliciano
An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6140-56.
1994: M N Lubaki; M A Egan; Robert Siliciano; K J Weinhold; Robert Bollinger
A novel method for detection and ex vivo expansion of HIV type 1-specific cytolytic T lymphocytes.
AIDS research and human retroviruses 1994;10(11):1427-31.
1994: R R Olson; J J Reuter; J McNicholl; C Alber; E Klohe; K Callahan; Robert Siliciano; R W Karr
Acidic residues in the DR beta chain third hypervariable region are required for stimulation of a DR(alpha, beta 1*0402)-restricted T-cell clone.
Human immunology 1994;41(3):193-200.
1994: E P Miskovsky; A Y Liu; W Pavlat; R Viveen; P E Stanhope; Diana Finzi; W M Fox; Ralph Hruban; Eckhard R Podack; Robert Siliciano
Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2787-99.
1994: R Paul Johnson; Scott A Hammond; Alicja Trocha; Robert Siliciano; Bruce D Walker
Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Journal of virology 1994;68(5):3145-53.
1994: R Paul Johnson; Scott A Hammond; Alicja Trocha; Robert Siliciano; Bruce D Walker
Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.
AIDS research and human retroviruses 1994;10 Suppl 2():S73-5.
1993: Robert Bollinger; Thomas C Quinn; A Y Liu; P E Stanhope; Scott A Hammond; R Viveen; M L Clements; Robert Siliciano
Cytokines from vaccine-induced HIV-1 specific cytotoxic T lymphocytes: effects on viral replication.
AIDS research and human retroviruses 1993;9(11):1067-77.
1993: K M Callahan; J F Rowell; Mark J Soloski; Carolyn E Machamer; Robert Siliciano
HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):2928-42.
1993: P E Stanhope; M L Clements; Robert Siliciano
Human CD4+ cytolytic T lymphocyte responses to a human immunodeficiency virus type 1 gp160 subunit vaccine.
The Journal of infectious diseases 1993;168(1):92-100.
1993: P E Stanhope; A Y Liu; W Pavlat; PAULA PITHA-ROWE; M L Clements; Robert Siliciano
An HIV-1 envelope protein vaccine elicits a functionally complex human CD4+ T cell response that includes cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4672-86.
1993: Robert Siliciano
CD4+ T cell epitopes in HIV-1 proteins.
Chemical immunology 1993;56():127-49.
1992: Scott A Hammond; Robert Bollinger; P E Stanhope; Thomas C Quinn; David H Schwartz; M L Clements; Robert Siliciano
Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines.
The Journal of experimental medicine 1992;176(6):1531-42.
1992: Robert Siliciano; Robert Bollinger; K M Callahan; Scott A Hammond; A Y Liu; E P Miskovsky; J F Rowell; P E Stanhope
Clonal analysis of T-cell responses to the HIV-1 envelope proteins in AIDS vaccine recipients.
AIDS research and human retroviruses 1992;8(8):1349-52.
1992: A Y Liu; E P Miskovsky; P E Stanhope; Robert Siliciano
Production of transmembrane and secreted forms of tumor necrosis factor (TNF)-alpha by HIV-1-specific CD4+ cytolytic T lymphocyte clones. Evidence for a TNF-alpha-independent cytolytic mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3789-98.
1991: J Novotny; R K Ganju; S T Smiley; R E Hussey; M A Luther; M A Recny; Robert Siliciano; Ellis L Reinherz
A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8646-50.
1991: Don J Diamond; P Szalay; D Symer; P Hao; H S Shin; RENEE DINTZIS; HOWARD DINTZIS; Ellis L Reinherz; Robert Siliciano
Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives.
The Journal of experimental medicine 1991;174(1):229-41.
1991: Scott A Hammond; E Obah; P Stanhope; C R Monell; M Strand; F M Robbins; W B Bias; R W Karr; Scott Koenig; Robert Siliciano
Characterization of a conserved T cell epitope in HIV-1 gp41 recognized by vaccine-induced human cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1470-7.
1990: R J Orentas; James E K Hildreth; E Obah; Michael Polydefkis; G E Smith; M L Clements; Robert Siliciano
Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine.
Science (New York, N.Y.) 1990;248(4960):1234-7.
1990: K M Callahan; M M Fort; E A Obah; Ellis L Reinherz; Robert Siliciano
Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3341-6.
1990: S Koyasu; T Lawton; D Novick; M A Recny; Robert Siliciano; B P Wallner; Ellis L Reinherz
Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(7):2603-7.
1990: Michael Polydefkis; Scott Koenig; Charles Flexner; E Obah; Kelly A Gebo; S Chakrabarti; Patricia L Earl; Bernard Moss; Robert Siliciano
Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.
The Journal of experimental medicine 1990;171(3):875-87.
1989: Robert Siliciano; C Knall; T Lawton; P Berman; T Gregory; Ellis L Reinherz
Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1506-11.
1988: Robert Siliciano; T Lawton; C Knall; R W Karr; P Berman; T Gregory; Ellis L Reinherz
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion.
Cell 1988;54(4):561-75.
1988: Rebecca E Hussey; N E Richardson; M Kowalski; N R Brown; Hsiu-Ching Chang; Robert Siliciano; Tatyana Dorfman; B Walker; Joseph Sodroski; Ellis L Reinherz
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.
Nature 1988;331(6151):78-81.
1987: C Milanese; Robert Siliciano; N E Richardson; H C Chang; A Alcover; Ellis L Reinherz
Human T lymphocyte activation.
Advances in experimental medicine and biology 1987;213():59-68.
1986: Robert Siliciano; T J Hemesath; J C Pratt; RENEE DINTZIS; HOWARD DINTZIS; Oreste Acuto; H S Shin; Ellis L Reinherz
Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones.
Cell 1986;47(2):161-71.
1986: C Milanese; Robert Siliciano; R E Schmidt; Jerome Ritz; N E Richardson; Ellis L Reinherz
A lymphokine that activates the cytolytic program of both cytotoxic T lymphocyte and natural killer clones.
The Journal of experimental medicine 1986;163(6):1583-8.
1985: Robert Siliciano; J C Pratt; R E Schmidt; Jerome Ritz; Ellis L Reinherz
Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.
Nature 1985;317(6036):428-30.
1985: Robert Siliciano; R M Colello; Achsah D Keegan; RENEE DINTZIS; HOWARD DINTZIS; H S Shin
Antigen valence determines the binding of nominal antigen to cytolytic T cell clones.
The Journal of experimental medicine 1985;162(2):768-73.
1985: Robert Siliciano; Achsah D Keegan; RENEE DINTZIS; HOWARD DINTZIS; H S Shin
The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):906-14.
1983: Robert Siliciano; Ron Brookmeyer; H S Shin
The diversity of T cell receptors specific for self MHC gene products.
Journal of immunology (Baltimore, Md. : 1950) 1983;130(4):1512-20.
1980: Robert Siliciano; C M Zacharchuk; H S Shin
H-2 restriction: independent recognition of H-2 and foreign antigen by a single receptor.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2192-6.
1979: R J Johnson; Robert Siliciano; H S Shin
Suppression of antibody-sensitized tumor cells by macrophages: insufficient supply or activation of macrophages within large tumors.
Journal of immunology (Baltimore, Md. : 1950) 1979;122(2):379-82.
1978: Robert Siliciano; C S Henney
Studies on the mechanism of lymphocyte-mediated cytolysis. X. Enucleated cells as targets for cytotoxic attack.
Journal of immunology (Baltimore, Md. : 1950) 1978;121(1):186-91.
1978: Robert Siliciano; Simeon Margolis; Paul S Lietman
Chloramphenicol metabolism in isolated rat hepatocytes.
Biochemical pharmacology 1978;27(23):2759-62.
1976: T Y Tsong; T T Tsong; E Kingsley; Robert Siliciano
Relaxation phenomena in human erythrocyte suspensions.
Biophysical journal 1976;16(9):1091-104.