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Arnold Spek

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Jan Willem Duitman; Tom van der Poll; Arie J Hoogendijk; C Arnold Spek
CCAAT/enhancer-binding protein δ: multifaceted regulator in respiratory disease.
Lisa G van den Hengel; Annemarie M van Oeveren-Rietdijk; Anton-Jan van Zonneveld; Henri H Versteeg; Hetty C de Boer; Margreet R De Vries; Jaap F Hamming; Alwine A Hellingman; Anne Yael Nossent; Pieter H Reitsma; C Arnold Spek; Paul H A Quax
Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model.
Daisy Machado; Diogo N Oliveira; Karla C S Queiroz; Silvia M Shishido; C Arnold Spek; Rodrigo R Catharino; Ana L C Faria; Carmen Veríssima Ferreira
Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo.

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2013: Jan Willem Duitman; Tom van der Poll; Arie J Hoogendijk; C Arnold Spek
CCAAT/enhancer-binding protein δ: multifaceted regulator in respiratory disease.
The American journal of pathology 2013;182(4):1459.
2013: Lisa G van den Hengel; Annemarie M van Oeveren-Rietdijk; Anton-Jan van Zonneveld; Henri H Versteeg; Hetty C de Boer; Margreet R De Vries; Jaap F Hamming; Alwine A Hellingman; Anne Yael Nossent; Pieter H Reitsma; C Arnold Spek; Paul H A Quax
Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model.
PloS one 2013;8(4):e61923.
2013: Daisy Machado; Diogo N Oliveira; Karla C S Queiroz; Silvia M Shishido; C Arnold Spek; Rodrigo R Catharino; Ana L C Faria; Carmen Veríssima Ferreira
Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo.
PloS one 2013;8(1):e54269.
2012: JanWillem Duitman; Sandrine Florquin; Angelique P Groot; Arie J Hoogendijk; Roberta R Ruela de Sousa; Tom van der Poll; C Arnold Spek
CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: potential role for macrophage migration.
The Journal of infectious diseases 2012;206(12):1826-35.
2012: Keren Borensztajn; Lois W Brüggemann; JanWillem Duitman; C Arnold Spek
Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(4):1056-7.
2012: Anne Q Reuwer; C Arnold Spek; Marcel Th B Twickler; Chris M van der Loos; Jan H von der Thüsen; Vincent Goffin; Arjan W Griffioen; Laurie A Mans; Patrycja Nowak-Sliwinska; Keren S Borensztajn
Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?
Journal of cellular and molecular medicine 2012;16(9):2035-48.
2012: Karla C S Queiroz; C Arnold Spek; Maikel P Peppelenbosch
Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2012;15(4):211-22.
2012: Janwillem Duitman; Sandrine Florquin; Angelique P Groot; Marcel Schouten; Joost B Daalhuisen; Tom van der Poll; C Arnold Spek
CCAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):9113-8.
2012: C Arnold Spek; Valder R Arruda
The protein C pathway in cancer metastasis.
Thrombosis research 2012;129 Suppl 1():S80-4.
2012: Monireh Dashty; Maikel P Peppelenbosch; Eric J Sijbrands; C Arnold Spek; Clark J Zeebregts; Vishtaseb Akbarkhanzadeh; Farhad Rezaee
Characterization of coagulation factor synthesis in nine human primary cell types.
Scientific reports 2012;2():787.
2012: Karla C S Queiroz; Roberta R Ruela-de-Sousa; C Arnold Spek; Willian F Zambuzzi; Sander H Diks; Nelson Duran; Carmen Veríssima Ferreira; Gwenny M Fuhler; Giselle Z Justo; Renato Milani; Maikel Peppelenbosch
Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse.
PloS one 2012;7(10):e45362.
2012: Karla C S Queiroz; Farhad Rezaee; C Arnold Spek; René A Tio; Clark J Zeebregts; Maria M Alves; Maarten F Bijlsma; Marina Dunaeva; Carmen V Ferreira; Gwenny M Fuhler; Ernst J Kuipers; Maikel P Peppelenbosch
Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques.
Molecular medicine (Cambridge, Mass.) 2012;18():1122-7.
2011: Netanel A Horowitz; Whitney M Miller; Brett P Monia; Eric S Mullins; Elizabeth A Blevins; Edward M Conway; Jay L Degen; Matthew J Flick; Ashley R Perry; Karla C S Queiroz; Kun Shi; C Arnold Spek; Kathryn E Talmage; Hartmut Weiler; Joseph S Palumbo
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.
Blood 2011;118(10):2889-95.
2011: Karla C S Queiroz; Joris J T H Roelofs; Hella L Aberson; Janwillem Duitman; Angelique P Groot; Anje A Te Velde; Yascha Van Den Berg; Cornelis van 't Veer; Henri H Versteeg; Marleen I Verstege; C Arnold Spek
Tissue factor-dependent chemokine production aggravates experimental colitis.
Molecular medicine (Cambridge, Mass.) 2011;17(9-10):1119-26.
2011: G L van Sluis; Lois W Brüggemann; Charles T Esmon; P W Kamphuisen; Dick J Richel; H R Büller; C J F van Noorden; C Arnold Spek
Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation.
Cancer letters 2011;306(1):106-10.
2011: Keren Borensztajn; C Arnold Spek
Blood coagulation factor Xa as an emerging drug target.
Expert opinion on therapeutic targets 2011;15(3):341-9.
2011: Heinz-Josef Klümpen; Karla C S Queiroz; C Arnold Spek; Carel J M van Noesel; Helmy C Brink; Wendy W J De Leng; Roeland F de Wilde; Elisabeth M H Mathus-Vliegen; G Johan A Offerhaus; Maarten A Alleman; Anneke M Westermann; Dirk J Richel
mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(6):e150-3.
2011: Keren S Borensztajn; Jan H von der Thüsen; C Arnold Spek
The role of coagulation in chronic inflammatory disorders: a jack of all trades.
Current pharmaceutical design 2011;17(1):9-16.
2010: Karla C S Queiroz; R R Ruela-de-Sousa; Gwenny M Fuhler; H L Aberson; Carmen Veríssima Ferreira; Maikel Peppelenbosch; C Arnold Spek
Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.
Oncogene 2010;29(48):6314-22.
2010: Keren Borensztajn; Paul Bresser; Chris M van der Loos; Ilze Bot; Bernt van den Blink; Michael A den Bakker; Joost Daalhuisen; Angelique P Groot; Maikel Peppelenbosch; Jan H von der Thüsen; C Arnold Spek
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis.
The American journal of pathology 2010;177(6):2753-64.
2010: Karla C S Queiroz; Rene A Tio; Clark J Zeebregts; Maarten F Bijlsma; Felix Zijlstra; Bahram Badlou; Marcel de Vries; Carmen V Ferreira; C Arnold Spek; Maikel Peppelenbosch; Farhad Rezaee
Human plasma very low density lipoprotein carries Indian hedgehog.
Journal of proteome research 2010;9(11):6052-9.
2010: Lois W Brüggemann; Karla C S Queiroz; Khatera Zamani; Amber van Straaten; C Arnold Spek; Maarten F Bijlsma
Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer.
Cancer biology & therapy 2010;10(1):79-88.
2010: Keren Borensztajn; Maikel Peppelenbosch; C Arnold Spek
Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation.
Thrombosis research 2010;125(6):e323-8.
2010: C Arnold Spek; Maarten F Bijlsma; Karla C S Queiroz
Canonical Hedgehog signaling drives proangiogenic responses in endothelial cells.
Cell cycle (Georgetown, Tex.) 2010;9(9):1683.
2010: Cornelis J F Van Noorden; Geerte L van Sluis; C Arnold Spek
Experimental and clinical effects of anticoagulants on cancer progression.
Thrombosis research 2010;125 Suppl 2():S77-9.
2010: Geerte L van Sluis; Harry R Büller; C Arnold Spek
The role of activated protein C in cancer progression.
Thrombosis research 2010;125 Suppl 2():S138-42.
2010: C Arnold Spek; Lois W Brüggemann; Keren S Borensztajn
Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure.
Shock (Augusta, Ga.) 2010;33(3):339; author reply 339-40.
2010: Clara P W Klerk; Tatjana M H Niers; Lois W Brüggemann; Susanne M Smorenburg; Dick J Richel; C Arnold Spek; Cornelis J F Van Noorden
Prophylactic plasma levels of the low molecular weight heparin nadroparin does not affect colon cancer tumor development in mouse liver.
Thrombosis research 2010;125(3):235-8.
2010: Martijn D de Kruif; Maarten Limper; Herman Gerritsen; C Arnold Spek; D P M Brandjes; Hugo ten Cate; Patrick M Bossuyt; Pieter H Reitsma; Eric C M van Gorp
Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department.
Critical care medicine 2010;38(2):457-63.
2010: Martijn D de Kruif; Maarten Limper; Karlien Sierhuis; Jiri F P Wagenaar; C Arnold Spek; Cecilia Garlanda; Alessia Cotena; Alberto Mantovani; Hugo ten Cate; Pieter H Reitsma; Eric C M van Gorp
PTX3 predicts severe disease in febrile patients at the emergency department.
The Journal of infection 2010;60(2):122-7.
2010: Geerte L Van Sluis; Max Nieuwdorp; Pieter W Kamphuisen; Johan Van der Vlag; Cornelis J F Van Noorden; C Arnold Spek
A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx.
PloS one 2010;5(6):e11200.
2010: Eefje Jong; Joost C M Meijers; Eric C M van Gorp; C Arnold Spek; Jan W Mulder
Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir.
AIDS research and therapy 2010;7():9.
2010: Keren Borensztajn; Jan H von der Thüsen; Maikel P Peppelenbosch; C Arnold Spek
The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm.
Journal of cellular and molecular medicine 2010;14(1-2):143-53.
2009: Jacquelyn Miller; Anika Agarwal; Lakshmi A Devi; Kellen Fontanini; James A Hamilton; Jean-Philippe Pin; Denis C Shields; C Arnold Spek; Thomas P Sakmar; Athan Kuliopulos; Stephen W Hunt
Insider access: pepducin symposium explores a new approach to GPCR modulation.
Annals of the New York Academy of Sciences 2009;1180 Suppl 1():E1-12.
2009: Geerte L Van Sluis; Tatjana M H Niers; Charles T Esmon; W Tigchelaar; Dick J Richel; Harry R Buller; Cornelis J F Van Noorden; C Arnold Spek
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.
Blood 2009;114(9):1968-73.
2009: Maarten F Bijlsma; Angelique P Groot; Jeremiah P Oduro; Rutger J Franken; Saskia H H F Schoenmakers; Maikel P Peppelenbosch; C Arnold Spek
Hypoxia induces a hedgehog response mediated by HIF-1alpha.
Journal of cellular and molecular medicine 2009;13(8B):2053-60.
2009: Sarah T B G Loubele; C Arnold Spek; Peter Leenders; René Van Oerle; Hella L Aberson; Karly Hamulyák; Gary Ferrell; Charles T Esmon; Henri M H Spronk; Hugo ten Cate
Activated protein C protects against myocardial ischemia/ reperfusion injury via inhibition of apoptosis and inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1087-92.
2009: Radjesh J Bisoendial; Rakesh S Birjmohun; Fatima Akdim; Cornelis van 't Veer; C Arnold Spek; Daniel Hartman; Eric de Groot; Danute M Bankaitis-Davis; John J P Kastelein; Erik S G Stroes
C-reactive protein elicits white blood cell activation in humans.
The American journal of medicine 2009;122(6):582.e1-9.
2009: Keren Borensztajn; Maarten F Bijlsma; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation.
Thrombosis research 2009;124(2):219-25.
2009: Keren Borensztajn; Hella Aberson; Maikel P Peppelenbosch; C Arnold Spek
FXa-induced intracellular signaling links coagulation to neoangiogenesis: potential implications for fibrosis.
Biochimica et biophysica acta 2009;1793(5):798-805.
2009: Keren Borensztajn; Hella Aberson; Angelique P Groot; Maikel P Peppelenbosch; C Arnold Spek
A mechanism for thrombin-dependent lung metastasis in patients with osteosarcoma.
British journal of haematology 2009;145(4):548-50.
2009: Monia Monti; Keren S Borensztajn; Mirko Pinotti; Alessandro Canella; Alessio Branchini; Giovanna Marchetti; Pieter H Reitsma; francesco bernardi; C Arnold Spek
Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity.
Thrombosis research 2009;123(6):914-8.
2009: Mark C Dessing; Koenraad F van der Sluijs; C Arnold Spek; Tom van der Poll
Gene expression profiles in murine influenza pneumonia.
Journal of innate immunity 2009;1(4):366-75.
2009: T M H Niers; Lois W Brüggemann; Clara P W Klerk; Femke J M Muller; Tessa Buckle; Pieter H Reitsma; Dick J Richel; C Arnold Spek; Olaf van Tellingen; Cornelis J F Van Noorden
Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung.
Clinical & experimental metastasis 2009;26(3):171-8.
2009: Keren Borensztajn; Maikel P Peppelenbosch; C Arnold Spek
Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease?
Trends in pharmacological sciences 2009;30(1):8-16.
2008: Lois W Brüggemann; Henri H Versteeg; Tatjana M Niers; Pieter H Reitsma; C Arnold Spek
Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders.
Journal of cellular and molecular medicine 2008;12(6B):2622-7.
2008: Keren Borensztajn; Maikel Peppelenbosch; C Arnold Spek
Factor Xa: at the crossroads between coagulation and signaling in physiology and disease.
Trends in molecular medicine 2008;14(10):429-40.
2008: Maarten F Bijlsma; Peter J A Leenders; Ben J A Janssen; Maikel Peppelenbosch; Hugo ten Cate; C Arnold Spek
Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury.
Experimental biology and medicine (Maywood, N.J.) 2008;233(8):989-96.
2008: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek; Henk Roelink
Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation.
Stem cells (Dayton, Ohio) 2008;26(5):1138-45.
2008: Keren Borensztajn; Jurriën Stiekema; Sebastiaan Nijmeijer; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation.
The American journal of pathology 2008;172(2):309-20.
2008: Keren S Borensztajn; C Arnold Spek
Protease-activated receptors, apoptosis and tumor growth.
Pathophysiology of haemostasis and thrombosis 2008;36(3-4):137-47.
2008: Jantine van Baal; Agnieszka M Rygiel; Francesca Milano; M Anderson; Jacques J G H M Bergman; C Arnold Spek; Kenneth K Wang; Maikel Peppelenbosch; Kausilia K Krishnadath
Gene expression profile comparison of Barrett's esophagus epithelial cell cultures and biopsies.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E 2008;21(7):628-33.
2008: Martijn D de Kruif; Tatty E Setiati; Albert T A Mairuhu; Penelope Koraka; Hella A Aberson; C Arnold Spek; Albert D M E Osterhaus; Pieter H Reitsma; D P M Brandjes; Augustinus Soemantri; Eric C M van Gorp
Differential gene expression changes in children with severe dengue virus infections.
PLoS neglected tropical diseases 2008;2(4):e215.
2008: Jantine van Baal; Francesco Milana; Agnieszka M Rygiel; Carine M T Sondermeijer; C Arnold Spek; Jacques J G H M Bergman; Maikel Peppelenbosch; Kausilia K Krishnadath
A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(1):63-75.
2008: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
(Pro-)vitamin D as treatment option for hedgehog-related malignancies.
Medical hypotheses 2008;70(1):202-3.
2007: Maarten F Bijlsma; Keren S Borensztajn; Henk Roelink; Maikel Peppelenbosch; C Arnold Spek
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites.
Cellular signalling 2007;19(12):2596-604.
2007: Sjoukje H Slofstra; Maarten F Bijlsma; Angelique P Groot; Pieter H Reitsma; Theo Lindhout; Hugo ten Cate; C Arnold Spek
Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation.
Blood 2007;110(9):3176-82.
2007: Hjalmar R Hansen; Jef L Wolfs; Lois Bruggemann; Dirkje W Sommeijer; Eduard Bevers; Arnaud D Hauer; Johan Kuiper; C Arnold Spek; Henri M H Spronk; Pieter H Reitsma; Hugo ten Cate
Hyperglycemia accelerates arterial thrombus formation and attenuates the antithrombotic response to endotoxin in mice.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(7):627-36.
2007: Sjoukje H Slofstra; Angelique P Groot; Maartje H P Obdeijn; Pieter H Reitsma; Hugo ten Cate; C Arnold Spek
Gene expression profiling identifies C/EBPdelta as a candidate regulator of endotoxin-induced disseminated intravascular coagulation.
American journal of respiratory and critical care medicine 2007;176(6):602-9.
2007: C Arnold Spek; Fiebo J W Ten Kate; Anje A Te Velde
Factor V Leiden and the etiology of inflammatory bowel disease.
Thrombosis and haemostasis 2007;98(3):670-3.
2007: Keren S Borensztajn; Maarten F Bijlsma; Angelique P Groot; Lois W Brüggemann; Henri H Versteeg; Pieter H Reitsma; Maikel Peppelenbosch; C Arnold Spek
Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.
Experimental cell research 2007;313(12):2622-33.
2007: Clara P W Klerk; Susanne M Smorenburg; C Arnold Spek; Cornelis J F Van Noorden
Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation.
Journal of cellular and molecular medicine 2007;11(3):561-8.
2006: Marieke A D van Zoelen; Kamran Bakhtiari; Mark C Dessing; Cornelis Van't Veer; C Arnold Spek; Michael W T Tanck; Joost C M Meijers; Tom van der Poll
Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells.
Thrombosis and haemostasis 2006;96(6):789-93.
2006: Sjoukje H Slofstra; Angelique P Groot; Nico A Maris; Pieter H Reitsma; H Ten Cate; C Arnold Spek
Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment.
British journal of pharmacology 2006;149(6):740-6.
2006: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
Hedgehog morphogen in cardiovascular disease.
Circulation 2006;114(18):1985-91.
2006: Maarten F Bijlsma; Maikel Peppelenbosch; C Arnold Spek
A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?
Development (Cambridge, England) 2006;133(20):3951; author reply 3952-3.
2006: Maarten F Bijlsma; C Arnold Spek; Maikel Peppelenbosch
Hedgehog turns lipoproteins into Janus-faced particles.
Trends in cardiovascular medicine 2006;16(7):217-20.
2006: Peter I Bonta; Claudia M van Tiel; Mariska Vos; Thijs W H Pols; Johannes V van Thienen; Valerie Ferreira; E Karin Arkenbout; Jurgen Seppen; C Arnold Spek; Tom van der Poll; Hans Pannekoek; Carlie J M de Vries
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2288-94.
2006: Nico A Maris; Mark C Dessing; Alex F de Vos; Paul Bresser; jaring s. van der zee; Henk M Jansen; C Arnold Spek; Tom van der Poll
Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):622-6.
2006: Sjoukje H Slofstra; Hugo ten Cate; C Arnold Spek
Signal transduction induced by activated protein C: no role in protection against sepsis?
Trends in molecular medicine 2006;12(8):374-81.
2006: Lois W Brüggemann; Saskia H H F Schoenmakers; Angelique P Groot; Pieter H Reitsma; C Arnold Spek
Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice.
Critical care medicine 2006;34(8):2201-6.
2006: Maarten F Bijlsma; C Arnold Spek; Danica Zivkovic; Sandra van de Water; Farhad Rezaee; Maikel Peppelenbosch
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
PLoS biology 2006;4(8):e232.
2006: Anita W Rijneveld; Sebastiaan Weijer; Paul Bresser; Sandrine Florquin; George P Vlasuk; William E Rote; C Arnold Spek; Pieter H Reitsma; jaring s. van der zee; Marcel Levi; Tom van der Poll
Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.
Critical care medicine 2006;34(6):1725-30.
2006: Lois W Brüggemann; J W Drijfhout; Pieter H Reitsma; C Arnold Spek
Alternatively spliced tissue factor in mice: induction by Streptococcus pneumoniae.
Journal of thrombosis and haemostasis : JTH 2006;4(4):918-20.
2006: Sjoukje H Slofstra; Hugo ten Cate; C Arnold Spek
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction.
Thrombosis journal 2006;4():13.
2005: Saskia H H F Schoenmakers; Lois W Brüggemann; Angelique P Groot; S Maijs; Pieter H Reitsma; C Arnold Spek
Role of coagulation FVIII in septic peritonitis assessed in hemophilic mice.
Journal of thrombosis and haemostasis : JTH 2005;3(12):2738-44.
2005: Nico A Maris; Alex F de Vos; Mark C Dessing; C Arnold Spek; René Lutter; Henk M Jansen; jaring s. van der zee; Paul Bresser; Tom van der Poll
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.
American journal of respiratory and critical care medicine 2005;172(7):878-84.
2005: Sjoukje H Slofstra; Cornelis van 't Veer; Wim A Buurman; Pieter H Reitsma; Hugo ten Cate; C Arnold Spek
Low molecular weight heparin attenuates multiple organ failure in a murine model of disseminated intravascular coagulation.
Critical care medicine 2005;33(6):1365-70.
2005: Stephanie Bezzina Wettinger; C J M Doggen; C Arnold Spek; Frits R Rosendaal; Pieter H Reitsma
High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells.
Blood 2005;105(5):2000-6.
2005: Saskia H H F Schoenmakers; Pieter H Reitsma; C Arnold Spek
Blood coagulation factors as inflammatory mediators.
Blood cells, molecules & diseases 2005;34(1):30-7.
2004: Saskia H H F Schoenmakers; Henri H Versteeg; Angelique P Groot; Pieter H Reitsma; C Arnold Spek
Tissue factor haploinsufficiency during endotoxin induced coagulation and inflammation in mice.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2185-93.
2004: Sebastiaan Weijer; Saskia H H F Schoenmakers; Sandrine Florquin; Marcel Levi; George P Vlasuk; William E Rote; Pieter H Reitsma; C Arnold Spek; Tom van der Poll
Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.
The Journal of infectious diseases 2004;189(12):2308-17.
2004: C Arnold Spek
Tissue factor: from 'just one of the coagulation factors' to a major player in physiology.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004;15 Suppl 1():S3-10.
2004: Henri H Versteeg; C Arnold Spek; Sjoukje H Slofstra; Sander H Diks; Dick J Richel; Maikel Peppelenbosch
FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production.
Circulation research 2004;94(8):1032-40.
2004: Henri H Versteeg; Dick J Richel; Maikel Peppelenbosch; C Arnold Spek
Concerted action of coagulation factors on cell survival.
Journal of thrombosis and haemostasis : JTH 2004;2(4):673-4.
2004: Maarten F Bijlsma; C Arnold Spek; Maikel Peppelenbosch
Hedgehog: an unusual signal transducer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(4):387-94.
2004: Saskia H H F Schoenmakers; Angelique P Groot; Sandrine Florquin; Pieter H Reitsma; C Arnold Spek
Blood cell-derived tissue factor influences host response during murine endotoxemia.
Blood cells, molecules & diseases 2004;32(2):325-33.
2004: Henri H Versteeg; C Arnold Spek; Dick J Richel; Maikel Peppelenbosch
Coagulation factors VIIa and Xa inhibit apoptosis and anoikis.
Oncogene 2004;23(2):410-7.
2004: Henri H Versteeg; C Arnold Spek; Maikel Peppelenbosch; Dick J Richel
Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):6-11.
2003: Eric Eldering; C Arnold Spek; Hella L Aberson; Annette Grummels; Ingrid A M Derks; Alex F de Vos; Cathal J McElgunn; Jan P Schouten
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways.
Nucleic acids research 2003;31(23):e153.
2003: Janine Dörffler-Melly; Martijn D de Kruif; Lothar A Schwarte; Rendrik F Franco; Sandrine Florquin; C Arnold Spek; Can Ince; Pieter H Reitsma; Hugo ten Cate
Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis.
Basic research in cardiology 2003;98(6):347-52.
2003: Henri H Versteeg; Maikel Peppelenbosch; C Arnold Spek
Tissue factor signal transduction in angiogenesis.
Carcinogenesis 2003;24(6):1009-13.
2003: Henri H Versteeg; H L Bresser; C Arnold Spek; Dick J Richel; Sander J H van Deventer; Maikel Peppelenbosch
Regulation of the p21Ras-MAP kinase pathway by factor VIIa.
Journal of thrombosis and haemostasis : JTH 2003;1(5):1012-8.
2003: C Arnold Spek; Annelies Verbon; Hella Aberson; John P Pribble; Cathal J McElgunn; Terence Turner; Tim Axtelle; Jan Schouten; Tom van der Poll; Pieter H Reitsma
Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo.
Journal of clinical immunology 2003;23(2):132-40.
2003: Maikel Peppelenbosch; Henri H Versteeg; C Arnold Spek
In silico tissue factor analysis: a bit-to-bit comparison.
Thrombosis and haemostasis 2003;89(3):592-3.
2003: Sjoukje H Slofstra; C Arnold Spek; Hugo ten Cate
Disseminated intravascular coagulation.
The hematology journal : the official journal of the European Haematology Association / EHA 2003;4(5):295-302.
2003: Annelies Verbon; Joost C M Meijers; C Arnold Spek; C Erik Hack; John P Pribble; Terence Turner; Pascale E P Dekkers; Tim Axtelle; Marcel Levi; Sander J H van Deventer; Pieter H Reitsma; Tom van der Poll
Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans.
The Journal of infectious diseases 2003;187(1):55-61.
2002: Maikel Peppelenbosch; C Arnold Spek
Type I diabetes: a role for tissue factor in pancreatic islet transplantation?
Lancet 2002;360(9350):1999-2000.
2001: Henri H Versteeg; Maikel Peppelenbosch; C Arnold Spek
The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling?
Thrombosis and haemostasis 2001;86(6):1353-9.
2001: Hugo ten Cate; Saskia H H F Schoenmakers; R Franco; Janneke J Timmerman; Angelique P Groot; C Arnold Spek; Pieter H Reitsma
Microvascular coagulopathy and disseminated intravascular coagulation.
Critical care medicine 2001;29(7 Suppl):S95-7; discussion S97-8.
2000: C Arnold Spek; P H Reitsma
Genetic risk factors for venous thrombosis.
Molecular genetics and metabolism 2000;71(1-2):51-61.
2000: Rendrik F Franco; Evert de Jonge; Pascale E P Dekkers; Janneke J Timmerman; C Arnold Spek; Sander J H van Deventer; P van Deursen; L van Kerkhoff; B van Gemen; Hugo ten Cate; Tom van der Poll; Pieter H Reitsma
The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation.
Blood 2000;96(2):554-9.