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Hal Broxmeyer

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Sherif S Farag; David R Jones; Steven Messina-Graham; Michael J Robertson; Jennifer Schwartz; Angie Secrest; Shivani Srivastava; R Matthew Strother; Lisa Wood; Rafat Abonour; Kenneth Cornetta; Hal E Broxmeyer
In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies.
Hal E Broxmeyer; Stephen E Braun; Scott Cooper; Maryse Etienne-Julan; Gen-Sheng Feng; Akihiko Gotoh; Xing Jun Li; Li Lu; Rebecca J Chan
Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function.
Ying Liu; Xuan Ou; Khalid Timani; Hal E Broxmeyer; Johnny J He
C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.

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2013: Sherif S Farag; David R Jones; Steven Messina-Graham; Michael J Robertson; Jennifer Schwartz; Angie Secrest; Shivani Srivastava; R Matthew Strother; Lisa Wood; Rafat Abonour; Kenneth Cornetta; Hal E Broxmeyer
In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies.
Stem cells and development 2013;22(7):1007-15.
2013: Hal E Broxmeyer; Stephen E Braun; Scott Cooper; Maryse Etienne-Julan; Gen-Sheng Feng; Akihiko Gotoh; Xing Jun Li; Li Lu; Rebecca J Chan
Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function.
Stem cells and development 2013;22(6):998-1006.
2013: Ying Liu; Xuan Ou; Khalid Timani; Hal E Broxmeyer; Johnny J He
C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.
Stem cells and development 2013;22(5):689-94.
2013: Hal E Broxmeyer
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration.
The Journal of experimental medicine 2013;210(2):205-8.
2013: Wen-Mei Yu; Jinhua Shen; Hal E Broxmeyer; TOREN FINKEL; Stanton L Gerson; Olga Jovanovic; Xia Liu; Elena E Pohl; Cheng-Kui Qu
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
Cell stem cell 2013;12(1):62-74.
2013: Weina Zhao; Jonathan Hoggatt; Louis M Pelus; Allison Bowers; Erin Haag Breese; Hal E Broxmeyer; Mark G Goebl; Maureen A Harrington
SIMPL Enhancement of Tumor Necrosis Factor-α Dependent p65-MED1 Complex Formation Is Required for Mammalian Hematopoietic Stem and Progenitor Cell Function.
PloS one 2013;8(4):e61123.
2012: Hal E Broxmeyer; Brahmananda R Chitteti; Scott Cooper; Sherif Farag; Giao Hangoc; Jonathan Hoggatt; Charlie Mantel; Steven Messina-Graham; Heather A O'Leary; Xuan Ou; Louis M Pelus; Sara L Rohrabaugh; Jennifer Speth; Edward F Srour; Timothy B Campbell
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Nature medicine 2012;18(12):1786-96.
2012: Deepali V Sawant; Sarita Sehra; Ryo Shinnakasu; Hal E Broxmeyer; Kate Englert; Giao Hangoc; Rohit Jadhav; Mark H Kaplan; Toshinori Nakayama; Evelyn T Nguyen; Narayanan Perumal; Alexander L Dent
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4759-69.
2012: Charlie Mantel; Steven Messina-Graham; Akira Moh; Scott Cooper; Xin-Yuan Fu; Giao Hangoc; Hal E Broxmeyer
Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.
Blood 2012;120(13):2589-99.
2012: Hal E Broxmeyer; Charlie Mantel
A ROSy future for metabolic regulation of HSC division.
Nature medicine 2012;18(9):1334-6.
2012: Hal E Broxmeyer
Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.
Annals of the New York Academy of Sciences 2012;1266():151-60.
2012: Hong Lian Jin; Jong Soo Kim; Su Jin Kim; Young June Kim; Hal E Broxmeyer; Kye-Seong Kim
Dynamic expression of specific miRNAs during erythroid differentiation of human embryonic stem cells.
Molecules and cells 2012;34(2):177-83.
2012: Hal E Broxmeyer; Scott Cooper; David S Franklin; Giao Hangoc; Charlie Mantel
Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells.
Stem cells and development 2012;21(10):1597-603.
2012: Hal E Broxmeyer; Kent W Christopherson; Scott Cooper; Giao Hangoc; Charlie Mantel; Gourapura J Renukaradhya; Randy R Brutkiewicz
CD1d expression on and regulation of murine hematopoietic stem and progenitor cells.
Blood 2012;119(24):5731-41.
2012: Hal E Broxmeyer; Scott Cooper; Giao Hangoc; Ferdinand Kappes; John Kinzfogl; Maureen Legendre; Nirit Mor-Vaknin; David M Markovitz
DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
Stem cells and development 2012;21(9):1449-54.
2012: Ying Liu; Khalid Timani; Johnny J He; Man-Ryul Lee; Hal E Broxmeyer
Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.
Stem cells and development 2012;21(6):829-33.
2012: Man Ryul Lee; Charlie Mantel; Nutan Prasain; Mervin C Yoder; Hee-Don Chae; Young-June Kim; Hal E Broxmeyer
Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming.
Stem cells (Dayton, Ohio) 2012;31(4):666-81.
2012: Hee-Don Chae; Man-Ryul Lee; Hal E Broxmeyer
5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation.
Stem cells (Dayton, Ohio) 2012;30(2):140-9.
2011: Young-June Kim; Su-Jung Park; Hal E Broxmeyer
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2291-301.
2011: Hal E Broxmeyer
Tension no longer, as Tensin2 is identified as a long-sought-after link between thrombopoietin-induced receptor signaling and activation of the PI3K/Akt pathway.
Cell cycle (Georgetown, Tex.) 2011;10(16):2624-5.
2011: Young-June Kim; Hal E Broxmeyer
Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance.
Critical reviews in oncology/hematology 2011;79(2):112-26.
2011: John Kinzfogl; Giao Hangoc; Hal E Broxmeyer
Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
Blood 2011;118(3):565-75.
2011: Charlie Mantel; Steven V Messina-Graham; Hal E Broxmeyer
Superoxide flashes, reactive oxygen species, and the mitochondrial permeability transition pore: potential implications for hematopoietic stem cell function.
Current opinion in hematology 2011;18(4):208-13.
2011: Hee-Don Chae; Hal E Broxmeyer
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells.
Stem cells and development 2011;20(7):1277-85.
2011: Mark H Kaplan; John Kinzfogl; David E Levy; Duy Pham; Sara L Rohrabaugh; Gretta L Stritesky; Norman Yeh; Randy R Brutkiewicz; Scott Cooper; Nicole L Glosson; Ritobrata Goswami; Giao Hangoc; Janice S Blum; Hal E Broxmeyer
STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.
Blood 2011;117(23):6198-201.
2011: Ying Liu; Khalid Timani; Charlie Mantel; Yan Fan; Giao Hangoc; Scott Cooper; Johnny J He; Hal E Broxmeyer
TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
Blood 2011;117(21):5643-51.
2011: Hal E Broxmeyer; Man-Ryul Lee; Giao Hangoc; Scott Cooper; Nutan Prasain; Young-June Kim; Coleen Mallett; Zhaohui Ye; Scott Witting; Kenneth Cornetta; Linzhao Cheng; Mervin C Yoder
Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood.
Blood 2011;117(18):4773-7.
2011: Sara L Rohrabaugh; Timothy B Campbell; Giao Hangoc; Hal E Broxmeyer
Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice.
Blood cells, molecules & diseases 2011;46(4):318-20.
2011: Sara L Rohrabaugh; Giao Hangoc; Mark R Kelley; Hal E Broxmeyer
Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.
Experimental hematology 2011;39(4):415-23.
2011: Hal E Broxmeyer
Erythropoietin surprises: an immune saga.
Immunity 2011;34(1):6-7.
2011: Kelly S Schweitzer; Brian H Johnstone; Jana Garrison; Natalia I Rush; Scott Cooper; Dmitry O Traktuev; Dongni Feng; Jeremy J Adamowicz; Mary Van Demark; Amanda J Fisher; Krzysztof Kamocki; Mary Beth Brown; Robert G Presson; Hal E Broxmeyer; Keith L March; Irina Petrache
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking.
American journal of respiratory and critical care medicine 2011;183(2):215-25.
2011: Xuan Ou; Hee-Don Chae; Rui-Hong Wang; William C Shelley; Scott Cooper; Tammi Taylor; Young-June Kim; Chu-Xia Deng; Mervin C Yoder; Hal E Broxmeyer
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse.
Blood 2011;117(2):440-50.
2010: Sung P Ha; Nicholas D Klemen; Garrett H Kinnebrew; Andrew G Brandmaier; Jon Marsh; Giao Hangoc; Douglas C Palmer; Nicholas P Restifo; Kenneth Cornetta; Hal E Broxmeyer; Christopher E Touloukian
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.
The Journal of clinical investigation 2010;120(12):4273-88.
2010: Jeong A Kim; Keith March; Hee-Don Chae; Brian Johnstone; Su-Jung Park; Todd Cook; Stephanie Merfeld-Clauss; Hal E Broxmeyer
Muscle-derived Gr1(dim)CD11b(+) cells enhance neovascularization in an ischemic hind limb mouse model.
Blood 2010;116(9):1623-6.
2010: Tammi Taylor; Young-June Kim; Xuan Ou; Wilbert Derbigny; Hal E Broxmeyer
Toll-like receptor 2 mediates proliferation, survival, NF-kappaB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells.
Stem cells and development 2010;19(9):1333-41.
2010: Charlie Mantel; Steve Messina-Graham; Hal E Broxmeyer
Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells.
Cell cycle (Georgetown, Tex.) 2010;9(10):2008-17.
2010: Hal E Broxmeyer
Will iPS cells enhance therapeutic applicability of cord blood cells and banking?
Cell stem cell 2010;6(1):21-4.
2010: Hal E Broxmeyer
Umbilical cord transplantation: epilogue.
Seminars in hematology 2010;47(1):97-103.
2010: Vanderson Rocha; Hal E Broxmeyer
New approaches for improving engraftment after cord blood transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(1 Suppl):S126-32.
2009: Sunanda Basu; Hal E Broxmeyer
CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7478-88.
2009: Hal E Broxmeyer; Scott Cooper; D M Hass; J K Hathaway; F B Stehman; Giao Hangoc
Experimental basis of cord blood transplantation.
Bone marrow transplantation 2009;44(10):627-33.
2009: Timothy B Campbell; Sunanda Basu; Giao Hangoc; Wen Tao; Hal E Broxmeyer
Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation.
Blood 2009;114(16):3392-401.
2009: Deborah J Stumpo; Hal E Broxmeyer; Toni Ward; Scott Cooper; Giao Hangoc; Yang Jo Chung; William C Shelley; Eric K Richfield; Manas K Ray; Mervin C Yoder; Peter D Aplan; Perry Blackshear
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.
Blood 2009;114(12):2401-10.
2008: Rita L Strack; Daniel E Strongin; Dibyendu Bhattacharyya; Wen Tao; Allison Berman; Hal E Broxmeyer; Robert J Keenan; Benjamin S Glick
A noncytotoxic DsRed variant for whole-cell labeling.
Nature methods 2008;5(11):955-7.
2008: Sara Rohrabaugh; Charlie Mantel; Hal E Broxmeyer
Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling.
Stem cells and development 2008;17(5):1017-20.
2008: Charlie Mantel; Rui-Hong Wang; Chuxia Deng; Hal E Broxmeyer
Sirt1, notch and stem cell "age asymmetry".
Cell cycle (Georgetown, Tex.) 2008;7(18):2821-5.
2008: Anna Pulliam; M Joe Hobson; Samantha L Ciccone; Yan Li; Shi Chen; Edward F Srour; Feng-Chun Yang; Hal E Broxmeyer; D Wade Clapp
AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice.
Experimental hematology 2008;36(9):1084-90.
2008: Ying Liu; Giao Hangoc; Timothy B Campbell; Michael Goodman; Wen Tao; Karen E Pollok; Edward F Srour; Hal E Broxmeyer
Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells.
Experimental hematology 2008;36(8):947-56.
2008: Charlie Mantel; Hal E Broxmeyer
Sirtuin 1, stem cells, aging, and stem cell aging.
Current opinion in hematology 2008;15(4):326-31.
2008: Pratibha Singh; Yongxue Yao; Abigail Weliver; Hal E Broxmeyer; Soon-Cheol Hong; Cheong-Hee Chang
Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow.
Stem cells (Dayton, Ohio) 2008;26(4):1009-16.
2008: Myung-Kwan Han; Eun-Kyung Song; Ying Guo; Xuan Ou; Charlie Mantel; Hal E Broxmeyer
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.
Cell stem cell 2008;2(3):241-51.
2008: Charlie Mantel; Ying Guo; Man Ryul Lee; Myung-Kwan Han; Sara Rhorabough; Kye-Seong Kim; Hal E Broxmeyer
Cells enter a unique intermediate 4N stage, not 4N-G1, after aborted mitosis.
Cell cycle (Georgetown, Tex.) 2008;7(4):484-92.
2008: Young-June Kim; Myung-Kwan Han; Hal E Broxmeyer
4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells.
Blood 2008;111(3):1378-86.
2008: Hal E Broxmeyer
Chemokines in hematopoiesis.
Current opinion in hematology 2008;15(1):49-58.
2008: Timothy B Campbell; Hal E Broxmeyer
CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation.
Frontiers in bioscience : a journal and virtual library 2008;13():1795-805.
2008: Ying Guo; Charlie Mantel; Robert Hromas; Hal E Broxmeyer
Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin.
Stem cells (Dayton, Ohio) 2008;26(1):30-4.
2007: Geling Li; Saeid Abediankenari; Young-June Kim; Timothy B Campbell; Shigeki Ito; Barbara Graham-Evans; Scott Cooper; Hal E Broxmeyer
TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors.
Blood 2007;110(8):2872-9.
2007: Seung G Kang; Hyungwook Lim; Ourania M Andrisani; Hal E Broxmeyer; Chang H Kim
Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3724-33.
2007: Sunanda Basu; Nicole T Ray; Simon J Atkinson; Hal E Broxmeyer
Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34+ cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3075-85.
2007: Hal E Broxmeyer
Mechanism unknown: prostaglandin E2 may improve HSC therapies.
Cell stem cell 2007;1(2):135-6.
2007: Hal E Broxmeyer; Jorge Alejandro Henao Mejia; Giao Hangoc; Cecilia N Barese; Mary C Dinauer; Scott Cooper
SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells.
Stem cells and development 2007;16(4):589-96.
2007: Hal E Broxmeyer; Sarita Sehra; Scott Cooper; Lisa M Toney; Saritha Kusam; Jim J Aloor; Christophe C Marchal; Mary C Dinauer; Alexander L Dent
Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.
Molecular and cellular biology 2007;27(15):5275-85.
2007: Jeffrey D Altenburg; Hal E Broxmeyer; Qingwen Jin; Scott Cooper; Sunanda Basu; Ghalib Alkhatib
A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities.
Journal of virology 2007;81(15):8140-8.
2007: Seiichi Okabe; Tetsuzo Tauchi; Akihiro Nakajima; Goro Sashida; Akihiko Gotoh; Hal E Broxmeyer; Junko H Ohyashiki; Kazuma Ohyashiki
Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis.
Stem cells and development 2007;16(3):503-14.
2007: Timothy B Campbell; Giao Hangoc; Ying Liu; Karen E Pollok; Hal E Broxmeyer
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice.
Stem cells and development 2007;16(3):347-54.
2007: Hal E Broxmeyer; Giao Hangoc; Scott Cooper; Timothy Campbell; Shigeki Ito; Charlie Mantel
AMD3100 and CD26 modulate mobilization, engraftment, and survival of hematopoietic stem and progenitor cells mediated by the SDF-1/CXCL12-CXCR4 axis.
Annals of the New York Academy of Sciences 2007;1106():1-19.
2007: S A Mehta; Kent W Christopherson; Poornima Bhat-Nakshatri; Robert J Goulet; Hal E Broxmeyer; L Kopelovich; Harikrishna Nakshatri
Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.
Oncogene 2007;26(23):3329-37.
2007: Charlie Mantel; Ying Guo; Man Ryul Lee; Min-Kyoung Kim; Myung-Kwan Han; Hirohiko Shibayama; Seiji Fukuda; Mervin C Yoder; Louis M Pelus; Kye-Seong Kim; Hal E Broxmeyer
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability.
Blood 2007;109(10):4518-27.
2007: Geling Li; Sunanda Basu; Myung-Kwan Han; Young-June Kim; Hal E Broxmeyer
Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12.
Blood 2007;109(8):3173-6.
2007: Hal E Broxmeyer; Alexander L Dent; Scott Cooper; Giao Hangoc; Zheng-Yu Wang; Wenjun Du; Jacquelyn Gervay-Haque; Venkataraman Sriram; Gourapura J Renukaradhya; Randy R Brutkiewicz
A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus.
Experimental hematology 2007;35(4 Suppl 1):87-93.
2007: Hal E Broxmeyer; Ji Li; Giao Hangoc; Scott Cooper; Wen Tao; Charlie Mantel; Barbara Graham-Evans; Nico Ghilardi; Frederic J de Sauvage
Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.
Experimental hematology 2007;35(4 Suppl 1):78-86.
2007: Wen Tao; Barbara-Graham Evans; Jing Yao; Scott Cooper; Kenneth Cornetta; Christopher B Ballas; Giao Hangoc; Hal E Broxmeyer
Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not.
Stem cells (Dayton, Ohio) 2007;25(3):670-8.
2007: Shigeki Ito; Charlie Mantel; Myung-Kwan Han; Sunanda Basu; Seiji Fukuda; Scott Cooper; Hal E Broxmeyer
Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells.
Blood 2007;109(5):1923-30.
2007: Charlie Mantel; Hal E Broxmeyer
A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling.
Cell cycle (Georgetown, Tex.) 2007;6(2):144-6.
2007: Jing Chen; Wen-Mei Yu; Hanako Daino; Hal E Broxmeyer; Brian J Druker; Cheng-Kui Qu
SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.
Blood 2007;109(2):778-85.
2006: Hal E Broxmeyer; Scott Cooper; Giao Hangoc; Cheong-Hee Chang
Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins.
Experimental hematology 2006;34(8):1078-84.
2006: Hal E Broxmeyer; Louis M Pelus; Chang H Kim; Giao Hangoc; Scott Cooper; Robert Hromas
Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-C.
Experimental hematology 2006;34(8):1069-77.
2006: Hal E Broxmeyer
Chemokines and chemokine receptors in hematopoiesis and immunology.
Experimental hematology 2006;34(8):965-6.
2006: Hal E Broxmeyer; Trevor Starnes; Heather Ramsey; Scott Cooper; Richard Dahl; Elizabeth Williamson; Robert Hromas
The IL-17 cytokine family members are inhibitors of human hematopoietic progenitor proliferation.
Blood 2006;108(2):770.
2006: Hyungwook Lim; Hal E Broxmeyer; Chang H Kim
Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):840-51.
2006: Hal E Broxmeyer; Anne-Claude Ginras; Nahum Sonenberg; Scott Cooper
Retraction. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1.
Blood 2006;107(12):4713.
2006: Nehal K Porecha; Kyle English; Giao Hangoc; Hal E Broxmeyer; Kent W Christopherson
Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: implications for hematopoietic stem cell transplantation.
Stem cells and development 2006;15(3):325-33.
2006: Ying Guo; Barbara Graham-Evans; Hal E Broxmeyer
Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells.
Stem cells (Dayton, Ohio) 2006;24(4):850-6.
2006: Seiichi Okabe; Tetsuzo Tauchi; Kazuma Ohyashiki; Hal E Broxmeyer
Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.
Blood cells, molecules & diseases 2006;36(2):308-14.
2006: Hal E Broxmeyer; Edward F Srour; Christie M Orschell; David A Ingram; Scott Cooper; P Artur Plett; Laura E Mead; Mervin C Yoder
Cord blood stem and progenitor cells.
Methods in enzymology 2006;419():439-73.
2005: Ying Guo; Giao Hangoc; Huimin Bian; Louis M Pelus; Hal E Broxmeyer
SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells.
Stem cells (Dayton, Ohio) 2005;23(9):1324-32.
2005: Sunanda Basu; Hal E Broxmeyer
Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12.
Blood 2005;106(2):485-93.
2005: Jizhong Zhang; Geling Li; sulay moreno; Milica Pantelic; Pei Zhang; Hal E Broxmeyer; Ying Liu; Lee Wetzler; Johnny J He; Tie Chen
Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7995-8002.
2005: Yong-Hao Hou; Edward F Srour; Heather Ramsey; Richard Dahl; Hal E Broxmeyer; Robert Hromas
Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4.
Blood 2005;105(9):3488-92.
2005: Hal E Broxmeyer; Christie M Orschell; D Wade Clapp; Giao Hangoc; Scott Cooper; P Artur Plett; W Conrad Liles; Xiaxin Li; Barbara Graham-Evans; Timothy B Campbell; Gary Calandra; Gary J Bridger; David C Dale; Edward F Srour
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist.
The Journal of experimental medicine 2005;201(8):1307-18.
2005: Geling Li; Young-June Kim; Hal E Broxmeyer
Macrophage colony-stimulating factor drives cord blood monocyte differentiation into IL-10(high)IL-12absent dendritic cells with tolerogenic potential.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4706-17.
2005: Seiji Fukuda; Hal E Broxmeyer; Louis M Pelus
Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1alpha(CXCL12)/CXCR4 axis.
Blood 2005;105(8):3117-26.
2005: Hal E Broxmeyer; Scott Cooper; Giao Hangoc; Chang H Kim
Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro.
Stem cells and development 2005;14(2):199-203.
2005: Hal E Broxmeyer; Scott Cooper; Laurence A Lasky; Frederic J de Sauvage
Identification of a massive reserve of hematopoietic progenitors in mice.
Stem cells and development 2005;14(2):105-10.
2005: W Conrad Liles; Elin Rodger; Hal E Broxmeyer; Christine Dehner; Karin Badel; Gary Calandra; Jeff Christensen; Brent Wood; Thomas H Price; David C Dale
Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist.
Transfusion 2005;45(3):295-300.
2005: Raymond Yick-Loi Yu; Xing Wang; Fiona J Pixley; J Jessica Yu; Alexander L Dent; Hal E Broxmeyer; E Richard Stanley; B Hilda Ye
BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production.
Blood 2005;105(4):1777-84.
2005: Seiichi Okabe; Seiji Fukuda; Young-June Kim; Masaru Niki; Louis M Pelus; Kazuma Ohyashiki; Pier Paolo Pandolfi; Hal E Broxmeyer
Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1.
Blood 2005;105(2):474-80.
2005: Hal E Broxmeyer
Biology of cord blood cells and future prospects for enhanced clinical benefit.
Cytotherapy 2005;7(3):209-18.
2005: Young-June Kim; Teresa M Stringfield; Yan Chen; Hal E Broxmeyer
Modulation of cord blood CD8+ T-cell effector differentiation by TGF-beta1 and 4-1BB costimulation.
Blood 2005;105(1):274-81.
2004: Graham C Parker; Marlene Anastassova-Kristeva; Hal E Broxmeyer; William Dodge; Leonard M Eisenberg; Ursula M Gehling; Louis M Guenin; Ralf Huss; Nicanor I Moldovan; Mahendra S Rao; Edward F Srour; Mervin C Yoder
Stem cells: shibboleths of development.
Stem cells and development 2004;13(6):579-84.
2004: Eun-Kyoung Joo; Hal E Broxmeyer; Hyung-Joo Kwon; Ho Bum Kang; Jin Sook Kim; Jong Seok Lim; Yong-Kyoung Choe; In Seong Choe; Pyung Keun Myung; Younghee Lee
Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e.
Stem cells and development 2004;13(5):563-70.
2004: Geling Li; Giao Hangoc; Hal E Broxmeyer
Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14+CD16++ cells derived from human monocytes.
Biochemical and biophysical research communications 2004;322(2):637-43.
2004: Kent W Christopherson; Giao Hangoc; Charlie Mantel; Hal E Broxmeyer
Modulation of hematopoietic stem cell homing and engraftment by CD26.
Science (New York, N.Y.) 2004;305(5686):1000-3.
2004: Kai Hübel; W Conrad Liles; Hal E Broxmeyer; Elin Rodger; Brent Wood; Scott Cooper; Giao Hangoc; Ronald T MacFarland; Gary J Bridger; Geoffrey Henson; Gary Calandra; David C Dale
Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist.
Supportive cancer therapy 2004;1(3):165-72.
2004: Wen Tao; Mu Wang; Emily D Voss; Ross R Cocklin; Jaime A Smith; Scott H Cooper; Hal E Broxmeyer
Comparative proteomic analysis of human CD34+ stem/progenitor cells and mature CD15+ myeloid cells.
Stem cells (Dayton, Ohio) 2004;22(6):1003-14.
2003: Brian Freie; Xiaxin Li; Samantha L M Ciccone; Kathy Nawa; Scott Cooper; Catherine Vogelweid; Laurel Schantz; Laura S Haneline; Attilio Orazi; Hal E Broxmeyer; Suk-Hee Lee; D Wade Clapp
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis.
Blood 2003;102(12):4146-52.
2003: Kent W Christopherson; Scott Cooper; Giao Hangoc; Hal E Broxmeyer
CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice.
Experimental hematology 2003;31(11):1126-34.
2003: Ling Liu; Chunjin Ding; Wei Zeng; Josef G Heuer; Jonathan W Tetreault; Timothy W Noblitt; Giao Hangoc; Scott Cooper; Kellie A Brune; Ganesh Sharma; Niles Fox; Scott W Rowlinson; Danise P Rogers; Derrick R Witcher; Peter K Lambooy; Victor J Wroblewski; James R Miller; Hal E Broxmeyer
Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20.
Blood 2003;102(9):3206-9.
2003: W Conrad Liles; Hal E Broxmeyer; Elin Rodger; Brent Wood; Kai Hübel; Scott Cooper; Giao Hangoc; Gary J Bridger; Geoffrey Henson; Gary Calandra; David C Dale
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.
Blood 2003;102(8):2728-30.
2003: Saroj Vadhan-Raj; Shreyaskumar Patel; Carlos E Bueso-Ramos; Jody Folloder; Nicholas Papadopolous; Andrew Burgess; Lyle D Broemeling; Hal E Broxmeyer; Robert S Benjamin
Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(16):3158-67.
2003: Mark H Kaplan; Hua-Chen Chang; Scott Cooper; Younghee Lee; Hal E Broxmeyer
Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines.
Journal of hematotherapy & stem cell research 2003;12(4):401-8.
2003: Geling Li; Young-June Kim; Charlie Mantel; Hal E Broxmeyer
P-selectin enhances generation of CD14+CD16+ dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):669-77.
2003: Younghee Lee; Hal E Broxmeyer; Charlie Mantel; Hyung-Joo Kwon; Jae Wha Kim; Jin Sook Kim; Durhan Kwon; In Seong Choe
Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells.
Experimental & molecular medicine 2003;35(3):222-6.
2003: Kent W Christopherson; Scott Cooper; Hal E Broxmeyer
Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells.
Blood 2003;101(12):4680-6.
2003: Gregory Helbig; Kent W Christopherson; Poornima Bhat-Nakshatri; Suresh Kumar; Hiromitsu Kishimoto; Kathy D Miller; Hal E Broxmeyer; Harikrishna Nakshatri
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4.
The Journal of biological chemistry 2003;278(24):21631-8.
2003: Hal E Broxmeyer; Lisa Kohli; Chang H Kim; Younghee Lee; Charlie Mantel; Scott Cooper; Giao Hangoc; Montaser Shaheen; Xiaxin Li; D Wade Clapp
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells.
Journal of leukocyte biology 2003;73(5):630-8.
2003: Wen Tao; Giao Hangoc; John W Hawes; Yue Si; Scott Cooper; Hal E Broxmeyer
Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide.
Experimental hematology 2003;31(3):251-60.
2003: Laura S Haneline; Xiaxin Li; Samantha L M Ciccone; Ping Hong; Yanzhu Yang; Hal E Broxmeyer; Suk-Hee Lee; Attilio Orazi; Edward F Srour; D Wade Clapp
Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution.
Blood 2003;101(4):1299-307.
2003: Won Y Kim; Hal E Broxmeyer; In-Seob Han; Doo H Park; Ki-Man Lee; Dass S Vinay; Byoung S Kwon
Effect of leukotactin-1 on the protection in vivo of myeloid progenitor cells against cytotoxic chemotherapeutics.
Journal of hematotherapy & stem cell research 2003;12(1):107-13.
2003: Jae-Sun Ra; Hal E Broxmeyer; Myung W Kim; In-Seob Han; Seung W Choi; Byoung S Kwon
Osteoprotegerin inhibits proliferation of myeloid progenitor cells.
Journal of hematotherapy & stem cell research 2003;12(1):33-8.
2003: Hal E Broxmeyer; Edward F Srour; Giao Hangoc; Scott Cooper; Stacie A Anderson; David M Bodine
High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):645-50.
2003: Hal E Broxmeyer; Scott Cooper; Lisa Kohli; Giao Hangoc; Younghee Lee; Charlie Mantel; D Wade Clapp; Chang H Kim
Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):421-9.
2002: Kent W Christopherson; Giao Hangoc; Hal E Broxmeyer
Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):7000-8.
2002: Seiichi Okabe; Seiji Fukuda; Hal E Broxmeyer
Src kinase, but not the src kinase family member p56lck, mediates stromal cell-derived factor 1alpha/CXCL12-induced chemotaxis of a T cell line.
Journal of hematotherapy & stem cell research 2002;11(6):923-8.
2002: Young-June Kim; Geling Li; Hal E Broxmeyer
4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34+ progenitor cells.
Journal of hematotherapy & stem cell research 2002;11(6):895-903.
2002: David L Mack; David S Leibowitz; Scott Cooper; Heather Ramsey; Hal E Broxmeyer; Robert Hromas
Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.
Immunology 2002;107(4):444-51.
2002: Young-June Kim; Randy R Brutkiewicz; Hal E Broxmeyer
Role of 4-1BB (CD137) in the functional activation of cord blood CD28(-)CD8(+) T cells.
Blood 2002;100(9):3253-60.
2002: Kevin Bacon; Marco Baggiolini; Hal E Broxmeyer; Richard Horuk; Ivan Lindley; Alberto Mantovani; Kouji Maysushima; Philip Murphy; Hisayuki Nomiyama; Joost Oppenheim; Antal Rot; Thomas J Schall; Monica Tsang; Robin Thorpe; Jo Van Damme; Meenu Wadhwa; Osamu Yoshie; Albert Zlotnik; Kathy Zoon
Chemokine/chemokine receptor nomenclature.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(10):1067-8.
2002: Charlie Mantel; Vasily M Gelfano; Young-June Kim; Andrew McDaniel; Younghee Lee; H Scott Boswell; Hal E Broxmeyer
P21waf-1-Chk1 pathway monitors G1 phase microtubule integrity and is crucial for restriction point transition.
Cell cycle (Georgetown, Tex.) 2002;1(5):327-36.
2002: Robert Hromas; Scott Cooper; Hal E Broxmeyer
The chemokine CCL21 protects normal marrow progenitors from Ara-C cytotoxicity.
Cancer chemotherapy and pharmacology 2002;50(2):163-6.
2002: Mushui Dai; Nathalie Chevallier; Stacie Stone; Michael C Heinrich; Melanie McConnell; Tanja Reuter; Hal E Broxmeyer; Jonathan D Licht; Li Lu; Maureen Hoatlin
The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific.
The Journal of biological chemistry 2002;277(29):26327-34.
2002: Trevor Starnes; Hal E Broxmeyer; Michael J Robertson; Robert Hromas
Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):642-6.
2002: Seiichi Okabe; Seiji Fukuda; Hal E Broxmeyer
Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line.
Experimental hematology 2002;30(7):761-6.
2002: Naoyuki Anzai; Younghee Lee; Buhyun Youn; Seiji Fukuda; Young-June Kim; Charlie Mantel; Makoto Akashi; Hal E Broxmeyer
C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors.
Blood 2002;99(12):4413-21.
2002: Younghee Lee; Akihiko Gotoh; Hyung-Joo Kwon; Minute You; Lisa Kohli; Charlie Mantel; Scott Cooper; Giao Hangoc; Keisuke Miyazawa; Kazuma Ohyashiki; Hal E Broxmeyer
Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines.
Blood 2002;99(12):4307-17.
2002: Hal E Broxmeyer; Heather A Bruns; Shangming Zhang; Scott Cooper; Giao Hangoc; Andrew N J McKenzie; Alexander L Dent; Ulrike Schindler; Lisa K Naeger; Timothy Hoey; Mark H Kaplan
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M.
Immunity 2002;16(6):815-25.
2002: Byoung S Kwon; Jose C Hurtado; Zang Hee Lee; KyuBum Kwack; Su K Seo; Beom K Choi; Beverly H Koller; Godwin O Wolisi; Hal E Broxmeyer; Dass S Vinay
Immune responses in 4-1BB (CD137)-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5483-90.
2002: Buhyun Youn; Kang-Yeol Yu; J Oh; J Lee; T-H Lee; Hal E Broxmeyer
Role of the CC chemokine receptor 9/TECK interaction in apoptosis.
Apoptosis : an international journal on programmed cell death 2002;7(3):271-6.
2001: Trevor Starnes; Michael J Robertson; George W Sledge; Stephanie Kelich; Harikrishna Nakshatri; Hal E Broxmeyer; Robert Hromas
Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4137-40.
2001: Buhyun Youn; Young-June Kim; Charlie Mantel; Kang-Yeol Yu; Hal E Broxmeyer
Blocking of c-FLIP(L)--independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction.
Blood 2001;98(4):925-33.
2001: Young-June Kim; Hal E Broxmeyer
Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells.
Journal of hematotherapy & stem cell research 2001;10(4):441-9.
2001: Hal E Broxmeyer
Regulation of hematopoiesis by chemokine family members.
International journal of hematology 2001;74(1):9-17.
2001: Hal E Broxmeyer; Buhyun Youn; C Kim; Giao Hangoc; Scott Cooper; Charlie Mantel
Chemokine regulation of hematopoiesis and the involvement of pertussis toxin-sensitive G alpha i proteins.
Annals of the New York Academy of Sciences 2001;938():117-27; discussion 127-8.
2001: S H Cooper; Hal E Broxmeyer
Measurement of interleukin 3 and other hematopoietic cytokines, such as GM-CSF, G-CSF, M-CSF, erythropoietin, steel factor, and Flt-3 ligand.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 6():Unit 6.4.
2001: Younghee Lee; Hal E Broxmeyer
Synergistic activation of RSK correlates with c-fos induction in MO7e cells stimulated with GM-CSF plus Steel factor.
Biochemical and biophysical research communications 2001;281(4):897-901.
2001: Charlie Mantel; SE Braun; Younghee Lee; Young-June Kim; Hal E Broxmeyer
The interphase microtubule damage checkpoint defines an S-phase commitment point and does not require p21(waf-1).
Blood 2001;97(5):1505-7.
2001: M Crow; D D Taub; S Cooper; Hal E Broxmeyer; Andreas H Sarris
Human recombinant interferon-inducible protein-10: intact disulfide bridges are not required for inhibition of hematopoietic progenitors and chemotaxis of T lymphocytes and monocytes.
Journal of hematotherapy & stem cell research 2001;10(1):147-56.
2001: Younghee Lee; Charlie Mantel; Naoyuki Anzai; SE Braun; Hal E Broxmeyer
Transcriptional and ERK1/2-dependent synergistic upregulation of p21(cip1/waf1) associated with steel factor synergy in MO7e.
Biochemical and biophysical research communications 2001;280(3):675-83.
2001: Charlie Mantel; P Hendrie; Hal E Broxmeyer
Steel factor regulates cell cycle asymmetry.
Stem cells (Dayton, Ohio) 2001;19(6):483-91.
2000: L Lu; Mushui Dai; Y Ge; LS Wang; SE Braun; Cecily L Wait; Diana J Griffith; Michael C Heinrich; Hal E Broxmeyer
Co-transduction of cDNAs for c-kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors.
Journal of hematotherapy & stem cell research 2000;9(6):813-25.
2000: Mushui Dai; Charlie Mantel; ZB Xia; Hal E Broxmeyer; L Lu
An expansion phase precedes terminal erythroid differentiation of hematopoietic progenitor cells from cord blood in vitro and is associated with up-regulation of cyclin E and cyclin-dependent kinase 2.
Blood 2000;96(12):3985-7.
2000: BG Thomson; Kent A Robertson; Darla J Gowan; Douglas K Heilman; Hal E Broxmeyer; DJ Emanuel; Patricia Kotylo; Zacharie Brahmi; Franklin O Smith
Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation.
Blood 2000;96(8):2703-11.
2000: S Zhang; Hal E Broxmeyer
Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase.
Biochemical and biophysical research communications 2000;277(1):195-9.
2000: ZB Xia; Mushui Dai; C Magoulas; Hal E Broxmeyer; L Lu
Differentially expressed genes during in vitro differentiation of murine embryonic stem cells transduced with a human erythropoietin receptor cDNA.
Journal of hematotherapy & stem cell research 2000;9(5):651-8.
2000: L Lu; Y Ge; ZH Li; Mushui Dai; Hal E Broxmeyer
Enhancement of proliferation and differentiation of erythroid progenitors by co-transduction of erythropoietin receptor and H-ras cDNAS into single CD34(3+) cord blood cells.
Bone marrow transplantation 2000;26(8):817-22.
2000: S Zhang; Seiji Fukuda; Younghee Lee; Giao Hangoc; Scott Cooper; Rosanne Spolski; Warren J Leonard; Hal E Broxmeyer
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.
The Journal of experimental medicine 2000;192(5):719-28.
2000: L S Wang; H J Liu; ZB Xia; Hal E Broxmeyer; L Lu
Expression and activation of caspase-3/CPP32 in CD34(+) cord blood cells is linked to apoptosis after growth factor withdrawal.
Experimental hematology 2000;28(8):907-15.
2000: S E Braun; K Chen; R G Foster; Chang H Kim; Robert Hromas; M H Kaplan; Hal E Broxmeyer; Kenneth Cornetta
The CC chemokine CK beta-11/MIP-3 beta/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4025-31.
2000: L Lu; LS Wang; Ryan J Cooper; H J Liu; K Turner; N Weich; Hal E Broxmeyer
Suppressive effects of TNF-alpha, TGF-beta1, and chemokines on megakaryocytic colony formation in CD34+ cells derived from umbilical cord blood compared with mobilized peripheral blood and bone marrow.
Journal of hematotherapy & stem cell research 2000;9(2):195-204.
2000: S Fang; Rosemary Steinmetz; D Walker King; P Zeng; Catherine M Vogelweid; Scott Cooper; G Hangcoc; Hal E Broxmeyer; Ora Hirsch Pescovitz
Development of a transgenic mouse that overexpresses a novel product of the growth hormone-releasing hormone gene.
Endocrinology 2000;141(4):1377-83.
2000: Saroj Vadhan-Raj; Claire F Verschraegen; Carlos E Bueso-Ramos; Hal E Broxmeyer; A P Kudelkà; Ralph S Freedman; Creighton L Edwards; David M Gershenson; Denny Jones; Mark Ashby; John J Kavanagh
Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer.
Annals of internal medicine 2000;132(5):364-8.
2000: Mushui Dai; Michael C Heinrich; Hal E Broxmeyer; L Lu
Enhancing effects of co-transduction of both human erythropoietin receptor and c-kit cDNAs into hematopoietic stem/progenitor cells from cord blood on proliferation and differentiation of erythroid progenitors.
Cytokines, cellular & molecular therapy 2000;6(1):1-8.
2000: L S Wang; H J Liu; Hal E Broxmeyer; L Lu
Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34+ cells from cord blood to fibronectin is associated with the PI-3 kinase pathway.
In vivo (Athens, Greece) 2000;14(2):331-7.
2000: Robert Hromas; Larry D Cripe; Giao Hangoc; S Cooper; Hal E Broxmeyer
The exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitors.
Blood 2000;95(4):1506-8.
2000: M Xiao; Z Luo; Charlie Mantel; Hal E Broxmeyer; L Lu
Transduction of human IL-9 receptor cDNA into TF1 cells induces IL-9 dependency and erythroid differentiation.
Journal of hematotherapy & stem cell research 2000;9(1):77-82.
2000: Mushui Dai; Y Ge; ZB Xia; Hal E Broxmeyer; L Lu
Introduction of human erythropoietin receptor complementary DNA by retrovirus-mediated gene transfer into murine embryonic stem cells enhances erythropoiesis in developing embryoid bodies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2000;6(4):395-407.
1999: J A Jayne; S Reid; S E Braun; Hal E Broxmeyer
Differential in vitro maturation of hematopoietic stem cells from wild-type and immunoglobulin transgenic mice.
Cytokines, cellular & molecular therapy 1999;5(4):195-204.
1999: C H Kim; Giao Hangoc; S Cooper; C D Helgason; S Yew; R K Humphries; G Krystal; Hal E Broxmeyer
Altered responsiveness to chemokines due to targeted disruption of SHIP.
The Journal of clinical investigation 1999;104(12):1751-9.
1999: B S Youn; Chang H Kim; F O Smith; Hal E Broxmeyer
TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor.
Blood 1999;94(7):2533-6.
1999: L Lu; Michael C Heinrich; LS Wang; Mushui Dai; AJ Zigler; L Chai; Hal E Broxmeyer
Retroviral-mediated gene transduction of c-kit into single hematopoietic progenitor cells from cord blood enhances erythroid colony formation and decreases sensitivity to inhibition by tumor necrosis factor-alpha and transforming growth factor-beta1.
Blood 1999;94(7):2319-32.
1999: C H Kim; Cheng-Kui Qu; Giao Hangoc; Scott Cooper; N Anzai; Gen-Sheng Feng; Hal E Broxmeyer
Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.
The Journal of experimental medicine 1999;190(5):681-90.
1999: S Reid; Hal E Broxmeyer
The effects of GM-CSF, steel factor and MIP-1alpha on the expression and activation of Cdc25A phosphatase in Mo7e cells.
Cytokines, cellular & molecular therapy 1999;5(3):129-38.
1999: S E Braun; K Chen; B R Blazar; P J Orchard; George W Sledge; Michael J Robertson; Hal E Broxmeyer; Kenneth Cornetta
Flt3 ligand antitumor activity in a murine breast cancer model: a comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action.
Human gene therapy 1999;10(13):2141-51.
1999: Chang H Kim; Hal E Broxmeyer
SLC/exodus2/6Ckine/TCA4 induces chemotaxis of hematopoietic progenitor cells: differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis vs. suppression of progenitor proliferation.
Journal of leukocyte biology 1999;66(3):455-61.
1999: A Ritchie; Hal E Broxmeyer
Suppression of p53-mediated growth factor withdrawal-induced apoptosis in the myeloid compartment by hematopoietic cytokines: an overview of hematopoiesis and apoptosis with a presentation of thrombopoietin and the M07E cell line as a model system.
Critical reviews in oncology/hematology 1999;31(3):169-91.
1999: A Gotoh; S Reid; Keisuke Miyazawa; Hal E Broxmeyer
SDF-1 suppresses cytokine-induced adhesion of human haemopoietic progenitor cells to immobilized fibronectin.
British journal of haematology 1999;106(1):171-4.
1999: Hal E Broxmeyer; Chang H Kim
Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities.
Experimental hematology 1999;27(7):1113-23.
1999: Robert Hromas; Hal E Broxmeyer; C Kim; Kent W Christopherson; Yong-Hao Hou
Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension.
Biochemical and biophysical research communications 1999;258(3):737-40.
1999: Naoyuki Anzai; Akihiko Gotoh; Hirohiko Shibayama; Hal E Broxmeyer
Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: possible involvement of protein tyrosine kinase and phospholipase C-gamma.
Blood 1999;93(10):3317-26.
1999: Chang H Kim; Louis M Pelus; Edward R Appelbaum; Kyung O Johanson; N Anzai; Hal E Broxmeyer
CCR7 ligands, SLC/6Ckine/Exodus2/TCA4 and CKbeta-11/MIP-3beta/ELC, are chemoattractants for CD56(+)CD16(-) NK cells and late stage lymphoid progenitors.
Cellular immunology 1999;193(2):226-35.
1999: Charlie Mantel; A Balduini; Hal E Broxmeyer
A human factor-dependent cell line simulates cobblestone formation under human bone marrow stromal cells in vitro.
Annals of the New York Academy of Sciences 1999;872():399-401.
1999: Chang H Kim; Hal E Broxmeyer
Thrombopoietin and interleukin-3 are chemotactic and chemokinetic chemoattractants for a factor-dependent hematopoietic progenitor cell line.
Annals of the New York Academy of Sciences 1999;872():395-8.
1999: Hal E Broxmeyer; Chang H Kim; S H Cooper; Giao Hangoc; Robert Hromas; Louis M Pelus
Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors.
Annals of the New York Academy of Sciences 1999;872():142-62; discussion 163.
1999: S Zhang; Charlie Mantel; Hal E Broxmeyer
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
Journal of leukocyte biology 1999;65(3):372-80.
1999: Hirohiko Shibayama; Naoyuki Anzai; SE Braun; Seiji Fukuda; Charlie Mantel; Hal E Broxmeyer
H-Ras is involved in the inside-out signaling pathway of interleukin-3-induced integrin activation.
Blood 1999;93(5):1540-8.
1999: S Reid; A Ritchie; Landin Boring; J Gosling; Scott Cooper; Giao Hangoc; Israel F Charo; Hal E Broxmeyer
Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2.
Blood 1999;93(5):1524-33.
1999: Robert Hromas; Hal E Broxmeyer; C Kim; Harikrishna Nakshatri; Kent W Christopherson; M Azam; Yong-Hao Hou
Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells.
Biochemical and biophysical research communications 1999;255(3):703-6.
1999: A Ritchie; SE Braun; J He; Hal E Broxmeyer
Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e.
Oncogene 1999;18(7):1465-77.
1999: Charlie Mantel; SE Braun; S Reid; Octavian Henegariu; L Liu; Giao Hangoc; Hal E Broxmeyer
p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells.
Blood 1999;93(4):1390-8.
1999: L W Wu; S Reid; A Ritchie; Hal E Broxmeyer; David B Donner
The proteasome regulates caspase-dependent and caspase-independent protease cascades during apoptosis of MO7e hematopoietic progenitor cells.
Blood cells, molecules & diseases 1999;25(1):20-9.
1999: S Zhang; Hal E Broxmeyer
p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells.
Biochemical and biophysical research communications 1999;254(2):440-5.
1999: Chang H Kim; Hal E Broxmeyer
Chemokines: signal lamps for trafficking of T and B cells for development and effector function.
Journal of leukocyte biology 1999;65(1):6-15.
1998: Cheng-Kui Qu; Wen-Mei Yu; Biagio Azzarelli; S Cooper; Hal E Broxmeyer; Gen-Sheng Feng
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.
Molecular and cellular biology 1998;18(10):6075-82.
1998: Chang H Kim; Louis M Pelus; John White; Hal E Broxmeyer
Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2580-5.
1998: Hirohiko Shibayama; Naoyuki Anzai; A Ritchie; S Zhang; Charlie Mantel; Hal E Broxmeyer
Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B-lymphoid cells to fibronectin via activation of VLA-4 and VLA-5.
Cellular immunology 1998;187(1):27-33.
1998: Buhyun Youn; S Zhang; Hal E Broxmeyer; K Antol; M J Fraser; Giao Hangoc; Byoung S Kwon
Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.
Biochemical and biophysical research communications 1998;247(2):217-22.
1998: Chang H Kim; Louis M Pelus; John White; Hal E Broxmeyer
Differential chemotactic behavior of developing T cells in response to thymic chemokines.
Blood 1998;91(12):4434-43.
1998: S E Braun; Charlie Mantel; M Rosenthal; Scott Cooper; L Liu; Kent A Robertson; Robert Hromas; Hal E Broxmeyer
A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer.
Blood cells, molecules & diseases 1998;24(2):138-48.
1998: Y Ge; ZH Li; Mark S Marshall; Hal E Broxmeyer; L Lu
Involvement of H-ras in erythroid differentiation of TF1 and human umbilical cord blood CD34 cells.
Blood cells, molecules & diseases 1998;24(2):124-36; discussion 137.
1998: Laura S Haneline; Hal E Broxmeyer; Scott Cooper; Giao Hangoc; Madeleine Carreau; Manuel Buchwald; D Wade Clapp
Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice.
Blood 1998;91(11):4092-8.
1998: Buhyun Youn; S M Zhang; Hal E Broxmeyer; Scott Cooper; K Antol; M Fraser; Byoung S Kwon
Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1.
Blood 1998;91(9):3118-26.
1998: P Porcu; J Gaddy; Hal E Broxmeyer
Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4538-43.
1998: Y Ge; Hal E Broxmeyer; L Lu
Leukemia inhibitory factor and steel factor regulate tie message stability in CD34+ cells from human umbilical cord blood.
In vivo (Athens, Greece) 1998;12(2):149-53.
1998: Hal E Broxmeyer; A Orazi; N L Hague; G W Sledge; H Rasmussen; Michael S Gordon
Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancer.
Blood cells, molecules & diseases 1998;24(1):14-30.
1998: L Lu; ZH Li; J He; Y Ge; Susan Rice; Hal E Broxmeyer
Transduction of recombinant human erythropoietin receptor cDNA into daughter progenitors derived from single CD34(3+) cord blood cells changes the differentiation profile of daughter progenitors.
Journal of leukocyte biology 1998;63(3):389-94.
1998: Chang H Kim; Louis M Pelus; John White; E Applebaum; Kyung O Johanson; Hal E Broxmeyer
CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2418-24.
1998: A Balduini; S E Braun; Kenneth Cornetta; S Lyman; Hal E Broxmeyer
Comparative effects of retroviral-mediated gene transfer into primary human stromal cells of Flt3-ligand, interleukin 3 and GM-CSF on production of cord blood progenitor cells in long-term culture.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():37-49.
1998: Chang H Kim; Hal E Broxmeyer
In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment.
Blood 1998;91(1):100-10.
1997: Buhyun Youn; S M Zhang; E K Lee; D H Park; Hal E Broxmeyer; P M Murphy; M Locati; J E Pease; K K Kim; K Antol; Byoung S Kwon
Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5201-5.
1997: A Ritchie; Akihiko Gotoh; J Gaddy; SE Braun; Hal E Broxmeyer
Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax: potential mechanisms for survival enhancing effects.
Blood 1997;90(11):4394-402.
1997: Landin Boring; J Gosling; Stephen W Chensue; Steven Kunkel; Robert V Farese; Hal E Broxmeyer; Israel F Charo
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
The Journal of clinical investigation 1997;100(10):2552-61.
1997: Akihiko Gotoh; A Ritchie; H Takahira; Hal E Broxmeyer
Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells.
Annals of hematology 1997;75(5-6):207-13.
1997: Y Ge; ZH Li; Y P Yung; B J Ratzkin; Hal E Broxmeyer; L Lu
Up-regulation of Tie gene expression by leukemia inhibitory factor and steel factor in CD34+ cells from human umbilical cord blood.
Journal of leukocyte biology 1997;62(4):510-6.
1997: J Gaddy; Hal E Broxmeyer
Cord blood CD16+56- cells with low lytic activity are possible precursors of mature natural killer cells.
Cellular immunology 1997;180(2):132-42.
1997: R Hromas; C H Kim; M Klemsz; MD Krathwohl; K Fife; S Cooper; Carol T Schnizlein-Bick; Hal E Broxmeyer
Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2554-8.
1997: MD Krathwohl; Robert Hromas; D R Brown; Hal E Broxmeyer; K H Fife
Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9875-80.
1997: K Chen; SE Braun; S Lyman; Y Fan; CM Traycoff; Eric A Wiebke; J Gaddy; George W Sledge; Hal E Broxmeyer; Kenneth Cornetta
Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model.
Cancer research 1997;57(16):3511-6.
1997: A Gotoh; H Takahira; R L Geahlen; Hal E Broxmeyer
Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(6):721-9.
1997: SM Aronica; A C Gingras; N Sonenberg; Scott Cooper; N Hague; Hal E Broxmeyer
Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1.
Blood 1997;89(10):3582-95.
1997: Saroj Vadhan-Raj; Lesley J Murray; Carlos E Bueso-Ramos; Shreyaskumar Patel; Sekhar M Pothireddy; W Keith Hoots; T Johnston; Nicholas Papadopolous; W N Hittelman; DA Johnston; T A Yang; V E Paton; R L Cohen; Sue Hellmann; Robert S Benjamin; Hal E Broxmeyer
Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer.
Annals of internal medicine 1997;126(9):673-81.
1997: R Hromas; Patrick W Gray; David Chantry; Ronald Godiska; MD Krathwohl; K Fife; G I Bell; J Takeda; S Aronica; Michael S Gordon; S Cooper; Hal E Broxmeyer; M J Klemsz
Cloning and characterization of exodus, a novel beta-chemokine.
Blood 1997;89(9):3315-22.
1997: M Tian; Hal E Broxmeyer; Y Fan; Z Lai; Shaobo Zhang; SM Aronica; Scott Cooper; Robert M Bigsby; Rosemary Steinmetz; S J Engle; A Mestek; Jonathan D Pollock; Michael N Lehman; Heiko T Jansen; M Ying; Peter J Stambrook; Jay A Tischfield; Lei Yu
Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice.
The Journal of experimental medicine 1997;185(8):1517-22.
1997: H Takahira; Akihiko Gotoh; A Ritchie; Hal E Broxmeyer
Steel factor enhances integrin-mediated tyrosine phosphorylation of focal adhesion kinase (pp125FAK) and paxillin.
Blood 1997;89(5):1574-84.
1997: T Tauchi; K Miyazawa; G S Feng; Hal E Broxmeyer; K Toyama
A coiled-coil tetramerization domain of BCR-ABL is essential for the interactions of SH2-containing signal transduction molecules.
The Journal of biological chemistry 1997;272(2):1389-94.
1997: Hal E Broxmeyer; Charlie Mantel; SM Aronica
Biology and mechanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():69-77; discussion 78.
1997: A Gotoh; Hal E Broxmeyer
The function of BCR/ABL and related proto-oncogenes.
Current opinion in hematology 1997;4(1):3-11.
1997: Hal E Broxmeyer; Scott Cooper
High-efficiency recovery of immature haematopoietic progenitor cells with extensive proliferative capacity from human cord blood cryopreserved for 10 years.
Clinical and experimental immunology 1997;107 Suppl 1():45-53.
1997: SE Braun; R Scott McIvor; A S Davidson; M Hanna; CM Traycoff; D A Berebetsky; R Gonin; Hal E Broxmeyer; Kenneth Cornetta
Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance.
Cancer gene therapy 1997;4(1):26-32.
1997: S E Braun; SM Aronica; Y Ge; H Takahira; M Etienne-Julan; L Lu; M D Minden; S D Lyman; Hal E Broxmeyer
Retroviral mediated gene transfer of Flt3 ligand enhances proliferation and MAP kinase activity of AML5 cells.
Experimental hematology 1997;25(1):51-6.
1996: Charlie Mantel; Z Luo; J Canfield; S Braun; C Deng; Hal E Broxmeyer
Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo.
Blood 1996;88(10):3710-9.
1996: Hal E Broxmeyer; Scott Cooper; G Cacalano; N L Hague; E Bailish; M W Moore
Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue.
The Journal of experimental medicine 1996;184(5):1825-32.
1996: K Carver-Moore; Hal E Broxmeyer; Shiuh-Ming Luoh; Scott Cooper; J Peng; S A Burstein; M W Moore; Frederic J de Sauvage
Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice.
Blood 1996;88(3):803-8.
1996: Akihiko Gotoh; H Takahira; Charlie Mantel; S Litz-Jackson; H Scott Boswell; Hal E Broxmeyer
Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines.
Blood 1996;88(1):138-45.
1996: Hal E Broxmeyer; Scott Cooper; ZH Li; L Lu; A Sarris; M H Wang; M S Chang; D B Donner; E J Leonard
Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family.
Annals of hematology 1996;73(1):1-9.
1996: M Horie; Kathleen M Sakamoto; Hal E Broxmeyer
Regulation of egr-1 gene expression by retinoic acid in a human growth factor-dependent cell line.
International journal of hematology 1996;63(4):303-9.
1996: Hal E Broxmeyer
Is interleukin 17, an inducible cytokine that stimulates production of other cytokines, merely a redundant player in a sea of other biomolecules?
The Journal of experimental medicine 1996;183(6):2411-5.
1996: M Lisovsky; SE Braun; Y Ge; H Takahira; L Lu; V G Savchenko; S D Lyman; Hal E Broxmeyer
Flt3-ligand production by human bone marrow stromal cells.
Leukemia 1996;10(6):1012-8.
1996: SM Aronica; Hal E Broxmeyer
Advances in understanding the postreceptor mechanisms of action of GM-CSF, G-CSF, and Steel factor.
Current opinion in hematology 1996;3(3):185-90.
1996: A Ritchie; S Vadhan-Raj; Hal E Broxmeyer
Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line, M07e.
Stem cells (Dayton, Ohio) 1996;14(3):330-6.
1996: M Xiao; ZH Li; J McMahel; Hal E Broxmeyer; L Lu
Inhibitory effects of interleukin 12 on retroviral gene transduction into CD34 cord blood myeloid progenitors mediated by induction of tumor necrosis factor-alpha.
Journal of hematotherapy 1996;5(2):171-7.
1996: H Takahira; S D Lyman; Hal E Broxmeyer
Flt3 ligand prolongs survival of CD34++ + human umbilical cord blood myeloid progenitors in serum-depleted culture medium.
Annals of hematology 1996;72(3):131-5.
1996: L Lu; ZH Li; Hal E Broxmeyer
Recovery and characterization of CD34+ cord blood cells after cryopreservation.
In vivo (Athens, Greece) 1996;10(2):229-32.
1996: R N Shen; L Lu; Hans E Kaiser; Hal E Broxmeyer
Curative effect of split low dosage total-body irradiation on murine AIDS induced by Friend virus: the results and the possible mechanism.
In vivo (Athens, Greece) 1996;10(2):191-9.
1996: L Lu; R N Shen; Hal E Broxmeyer
Stem cells from bone marrow, umbilical cord blood and peripheral blood for clinical application: current status and future application.
Critical reviews in oncology/hematology 1996;22(2):61-78.
1996: L Lu; Y Ge; ZH Li; M Xiao; Hal E Broxmeyer
Influence of retroviral-mediated gene transduction of both the recombinant human erythropoietin receptor and interleukin-9 receptor genes into single CD34++CD33-or low cord blood cells on cytokine-stimulated erythroid colony formation.
Experimental hematology 1996;24(2):347-51.
1996: L Lu; Y Ge; ZH Li; Winifred Keeble; David Kabat; Grover C Bagby; Hal E Broxmeyer; Maureen Hoatlin
Retroviral transfer of the recombinant human erythropoietin receptor gene into single hematopoietic stem/progenitor cells from human cord blood increases the number of erythropoietin-dependent erythroid colonies.
Blood 1996;87(2):525-34.
1996: J Cheng; S Baumhueter; G Cacalano; K Carver-Moore; H Thibodeaux; R Thomas; Hal E Broxmeyer; Scott Cooper; N Hague; Malcolm A S Moore; Laurence A Lasky
Hematopoietic defects in mice lacking the sialomucin CD34.
Blood 1996;87(2):479-90.
1995: Hal E Broxmeyer; Scott Cooper; M Etienne-Julan; XS Wang; Selvarangan Ponnazhagan; S Braun; L Lu; Arun Srivastava
Cord blood transplantation and the potential for gene therapy. Gene transduction using a recombinant adeno-associated viral vector.
Annals of the New York Academy of Sciences 1995;770():105-15.
1995: Hal E Broxmeyer; Scott Cooper; Z H Li; L Lu; H Y Song; B S Kwon; R E Warren; D B Donner
Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor.
International journal of hematology 1995;62(4):203-15.
1995: F Luo; S Z Zhou; Scott Cooper; Nikhil C Munshi; H Scott Boswell; Hal E Broxmeyer; Arun Srivastava
Adeno-associated virus 2-mediated gene transfer and functional expression of the human granulocyte-macrophage colony-stimulating factor.
Experimental hematology 1995;23(12):1261-7.
1995: Hal E Broxmeyer; Scott Cooper; N Hague; L Benninger; A Sarris; Kenneth Cornetta; S Vadhan-Raj; P Hendrie; Charlie Mantel
Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice.
Annals of hematology 1995;71(5):235-46.
1995: Akihiko Gotoh; K Miyazawa; Kazuma Ohyashiki; Tetsuzo Tauchi; H Scott Boswell; Hal E Broxmeyer; K Toyama
Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein.
Experimental hematology 1995;23(11):1153-9.
1995: ZH Li; Hal E Broxmeyer; L Lu
Cryopreserved cord blood myeloid progenitor cells can serve as targets for retroviral-mediated gene transduction and gene-transduced progenitors can be cryopreserved and recovered.
Leukemia 1995;9 Suppl 1():S12-6.
1995: SM Aronica; Charlie Mantel; R Gonin; Mark S Marshall; A Sarris; Scott Cooper; N Hague; X F Zhang; Hal E Broxmeyer
Interferon-inducible protein 10 and macrophage inflammatory protein-1 alpha inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line.
The Journal of biological chemistry 1995;270(37):21998-2007.
1995: L Lu; Y Ge; ZH Li; Brian Freie; D Wade Clapp; Hal E Broxmeyer
CD34 stem/progenitor cells purified from cryopreserved normal cord blood can be transduced with high efficiency by a retroviral vector and expanded ex vivo with stable integration and expression of Fanconi anemia complementation C gene.
Cell transplantation 1995;4(5):493-503.
1995: L Lu; M Xiao; ZH Li; L K Jolliffe; S Jones; Hal E Broxmeyer; N Weich
Influence in vitro of IL-3/Epo fusion proteins compared with the combination of IL-3 plus Epo in enhancing the proliferation of single isolated erythroid and multipotential progenitor cells from human umbilical cord blood and adult bone marrow.
Experimental hematology 1995;23(10):1130-4.
1995: Buhyun Youn; I K Jang; Hal E Broxmeyer; Scott Cooper; N A Jenkins; D J Gilbert; N G Copeland; T A Elick; Malcolm J Fraser; Byoung S Kwon
A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2661-7.
1995: Hal E Broxmeyer; L Lu; Scott Cooper; L Ruggieri; ZH Li; S D Lyman
Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells.
Experimental hematology 1995;23(10):1121-9.
1995: Hal E Broxmeyer
Questions to be answered regarding umbilical cord blood hematopoietic stem and progenitor cells and their use in-transplantation.
Transfusion 1995;35(8):694-702.
1995: AK Hiett; KA Britton; N L Hague; Haywood L Brown; F B Stehman; Hal E Broxmeyer
Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.
Transfusion 1995;35(7):587-91.
1995: Charlie Mantel; Z Luo; Hal E Broxmeyer
Synergistic induction of phospholipid metabolism by granulocyte-macrophage colony stimulating factor and steel factor in human growth factor-dependent cell line, M07e.
Lipids 1995;30(7):641-7.
1995: M T Yip-Schneider; M Horie; Hal E Broxmeyer
Transcriptional induction of pim-1 protein kinase gene expression by interferon gamma and posttranscriptional effects on costimulation with steel factor.
Blood 1995;85(12):3494-502.
1995: J Gaddy; G Risdon; Hal E Broxmeyer
Cord blood natural killer cells are functionally and phenotypically immature but readily respond to interleukin-2 and interleukin-12.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(6):527-36.
1995: Hal E Broxmeyer; L Benninger; Scott Cooper; N Hague; R S Benjamin; S Vadhan-Raj
Effects of in vivo treatment with PIXY321 (GM-CSF/IL-3 fusion protein) on proliferation kinetics of bone marrow and blood myeloid progenitor cells in patients with sarcoma.
Experimental hematology 1995;23(4):335-40.
1995: Tetsuzo Tauchi; Hal E Broxmeyer
BCR/ABL signal transduction.
International journal of hematology 1995;61(3):105-12.
1995: G Risdon; J Gaddy; M Horie; Hal E Broxmeyer
Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):2413-7.
1995: Tetsuzo Tauchi; Gen-Sheng Feng; R Shen; Maureen Hoatlin; Grover C Bagby; David Kabat; L Lu; Hal E Broxmeyer
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
The Journal of biological chemistry 1995;270(10):5631-5.
1995: Charlie Mantel; SM Aronica; Z Luo; Mark S Marshall; Young-June Kim; Scott Cooper; N Hague; Hal E Broxmeyer
Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2342-50.
1995: Hal E Broxmeyer
Cord blood as an alternative source for stem and progenitor cell transplantation.
Current opinion in pediatrics 1995;7(1):47-55.
1995: K Miyazawa; D A Williams; Akihiko Gotoh; Jiroh Nishimaki; Hal E Broxmeyer; K Toyama
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.
Blood 1995;85(3):641-9.
1995: M Horie; Hal E Broxmeyer
The combination of Steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line.
Experimental hematology 1995;23(2):168-73.
1994: R N Shen; L Lu; Hans E Kaiser; Hal E Broxmeyer
Bio-immunotherapy for cancer in experimental studies and clinical application: current status and future challenges.
In vivo (Athens, Greece) 1994;8(5):643-52.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; Mark S Marshall; R Shen; Charlie Mantel; Tony Pawson; Hal E Broxmeyer
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
The Journal of biological chemistry 1994;269(40):25206-11.
1994: R N Shen; L Lu; P Young; H Shidnia; N B Hornback; Hal E Broxmeyer
Influence of elevated temperature on natural killer cell activity, lymphokine-activated killer cell activity and lectin-dependent cytotoxicity of human umbilical cord blood and adult blood cells.
International journal of radiation oncology, biology, physics 1994;29(4):821-6.
1994: P C Hendrie; Hal E Broxmeyer
Myeloid cell proliferation stimulated by Steel factor is pertussis toxin sensitive and enhanced by cholera toxin.
International journal of immunopharmacology 1994;16(7):547-60.
1994: S Z Zhou; Scott Cooper; L Y Kang; L Ruggieri; S Heimfeld; Arun Srivastava; Hal E Broxmeyer
Adeno-associated virus 2-mediated high efficiency gene transfer into immature and mature subsets of hematopoietic progenitor cells in human umbilical cord blood.
The Journal of experimental medicine 1994;179(6):1867-75.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; R Shen; H Y Song; David B Donner; Tony Pawson; Hal E Broxmeyer
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
The Journal of biological chemistry 1994;269(21):15381-7.
1994: Hal E Broxmeyer
Advances in understanding of biological effects of interleukin-11, leukemia inhibitory factor, and macrophage inflammatory protein 1 alpha.
Current opinion in hematology 1994;1(3):197-202.
1994: G Risdon; J Gaddy; F B Stehman; Hal E Broxmeyer
Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation.
Cellular immunology 1994;154(1):14-24.
1994: Scott Cooper; Charlie Mantel; Hal E Broxmeyer
Myelosuppressive effects in vivo with very low dosages of monomeric recombinant murine macrophage inflammatory protein-1 alpha.
Experimental hematology 1994;22(2):186-93.
1994: R N Shen; B Wu; L Lu; Hans E Kaiser; Hal E Broxmeyer
Recombinant human interleukin-1 alpha: a potent bio-immunomodifier in vivo in immunosuppressed mice induced by cyclophosphamide, retroviral infection and surgical stress.
In vivo (Athens, Greece) 1994;8(1):59-63.
1994: Charlie Mantel; K Miyazawa; Hal E Broxmeyer
Physical characteristics and polymerization during iron saturation of lactoferrin, a myelopoietic regulatory molecule with suppressor activity.
Advances in experimental medicine and biology 1994;357():121-32.
1994: G Risdon; J Gaddy; Hal E Broxmeyer
Allogeneic responses of human umbilical cord blood.
Blood cells 1994;20(2-3):566-70; discussion 571-2.
1994: L Lu; M Xiao; D Wade Clapp; ZH Li; Hal E Broxmeyer
Stable integration of retrovirally transduced genes into human umbilical cord blood high-proliferative potential colony-forming cells (HPP-CFC) as assessed after multiple HPP-CFC colony replatings in vitro.
Blood cells 1994;20(2-3):525-30.
1994: Hal E Broxmeyer; L Benninger; M Yip-Schneider; S E Braun
Commentary: a rapid proliferation assay for unknown co-stimulating factors in cord blood plasma possibly involved in enhancement of in vitro expansion and replating capacity of human hematopoietic stem/progenitor cells.
Blood cells 1994;20(2-3):492-7.
1994: Attilio Orazi; SE Braun; Hal E Broxmeyer
Commentary: Immunohistochemistry represents a useful tool to study human cell engraftment in SCID mice transplantation models.
Blood cells 1994;20(2-3):323-30.
1994: Y J Shi; R N Shen; L Lu; Hal E Broxmeyer
Comparative analysis of retroviral-mediated gene transduction into CD34+ cord blood hematopoietic progenitors in the presence and absence of growth factors.
Blood cells 1994;20(2-3):517-24.
1994: M Xiao; Hal E Broxmeyer; M Horie; S Grigsby; L Lu
Extensive proliferative capacity of single isolated CD34 human cord blood cells in suspension culture.
Blood cells 1994;20(2-3):455-66; discussion 466-7.
1994: L Ruggieri; S Heimfeld; Hal E Broxmeyer
Cytokine-dependent ex vivo expansion of early subsets of CD34+ cord blood myeloid progenitors is enhanced by cord blood plasma, but expansion of the more mature subsets of progenitors is favored.
Blood cells 1994;20(2-3):436-54.
1994: Hal E Broxmeyer; L Benninger; S R Patel; R S Benjamin; S Vadhan-Raj
Kinetic response of human marrow myeloid progenitor cells to in vivo treatment of patients with granulocyte colony-stimulating factor is different from the response to treatment with granulocyte-macrophage colony-stimulating factor.
Experimental hematology 1994;22(1):100-2.
1994: K Miyazawa; K Toyama; Akihiko Gotoh; P C Hendrie; Charlie Mantel; Hal E Broxmeyer
Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells.
Blood 1994;83(1):137-45.
1994: Tetsuzo Tauchi; H Scott Boswell; DW Leibowitz; Hal E Broxmeyer
Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway.
The Journal of experimental medicine 1994;179(1):167-75.
1993: Charlie Mantel; Z Luo; P Hendrie; Hal E Broxmeyer
Steel factor and granulocyte-macrophage colony stimulating factor act together to enhance choline-lipid turnover during synergistically stimulated proliferation of the human factor dependent cell line, M07E.
Biochemical and biophysical research communications 1993;197(2):978-84.
1993: M T Yip-Schneider; M Horie; Hal E Broxmeyer
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Experimental hematology 1993;21(13):1648-56.
1993: L Lu; M Xiao; D Wade Clapp; ZH Li; Hal E Broxmeyer
High efficiency retroviral mediated gene transduction into single isolated immature and replatable CD34(3+) hematopoietic stem/progenitor cells from human umbilical cord blood.
The Journal of experimental medicine 1993;178(6):2089-96.
1993: Z Zhou; Young-June Kim; Karen E Pollok; J Hurtado; J K Lee; Hal E Broxmeyer; Byoung S Kwon
Macrophage inflammatory protein-1 alpha rapidly modulates its receptors and inhibits the anti-CD3 mAb-mediated proliferation of T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4333-41.
1993: L Lu; M Xiao; B Wu; W X Wang; W R Yan; Hal E Broxmeyer; R N Shen
In vivo effects of purified recombinant human macrophage colony-stimulating factor in combination with local hyperthermia on tumor progression in B16a melanoma bearing mice.
International journal of hematology 1993;58(3):139-52.
1993: L Lu; M Xiao; S Grigsby; W X Wang; B Wu; R N Shen; Hal E Broxmeyer
Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum.
Experimental hematology 1993;21(11):1442-6.
1993: B Wu; R N Shen; W X Wang; Hal E Broxmeyer; L Lu
Antitumor effect of interleukin 7 in combination with local hyperthermia in mice bearing B16a melanoma cells.
Stem cells (Dayton, Ohio) 1993;11(5):412-21.
1993: S Z Zhou; Hal E Broxmeyer; Scott Cooper; Maureen A Harrington; Arun Srivastava
Adeno-associated virus 2-mediated gene transfer in murine hematopoietic progenitor cells.
Experimental hematology 1993;21(7):928-33.
1993: Hal E Broxmeyer; Barbara Sherry; Scott Cooper; L Lu; R Maze; M P Beckmann; Anthony Cerami; P Ralph
Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3448-58.
1993: Giao Hangoc; R Daub; R G Maze; J H Frederik Falkenburg; Hal E Broxmeyer; Maureen A Harrington
Regulation of myelopoiesis by murine fibroblastic and adipogenic cell lines.
Experimental hematology 1993;21(4):502-7.
1993: R Maze; M Horie; P Hendrie; S Vadhan-Raj; Guido Tricot; Michael S Gordon; J Nemunaitis; L K Ashman; Hal E Broxmeyer
Differential responses of myeloid progenitor cells from patients with myeloid leukemia and myelodysplasia to the costimulating effects of steel factor in vitro.
Experimental hematology 1993;21(4):545-51.
1993: Charlie Mantel; Young-June Kim; Scott Cooper; B Kwon; Hal E Broxmeyer
Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2232-6.
1993: Giao Hangoc; T Yin; Scott Cooper; P Schendel; YC Yang; Hal E Broxmeyer
In vivo effects of recombinant interleukin-11 on myelopoiesis in mice.
Blood 1993;81(4):965-72.
1993: C E Carow; Giao Hangoc; Hal E Broxmeyer
Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma.
Blood 1993;81(4):942-9.
1993: M Horie; Hal E Broxmeyer
Involvement of immediate-early gene expression in the synergistic effects of steel factor in combination with granulocyte-macrophage colony-stimulating factor or interleukin-3 on proliferation of a human factor-dependent cell line.
The Journal of biological chemistry 1993;268(2):968-73.
1993: C E Carow; Maureen A Harrington; Hal E Broxmeyer
Detection of human myeloid progenitor cells in a murine background.
Experimental hematology 1993;21(1):66-9.
1993: L Lu; M Xiao; R N Shen; S Grigsby; Hal E Broxmeyer
Enrichment, characterization, and responsiveness of single primitive CD34 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential.
Blood 1993;81(1):41-8.
1992: Giao Hangoc; C E Carow; R Schwall; A J Mason; Hal E Broxmeyer
Effects in vivo of recombinant human inhibin on myelopoiesis in mice.
Experimental hematology 1992;20(10):1243-6.
1992: Hal E Broxmeyer
Interactions of colony stimulating factors, other modulating cytokines and hematopoietic progenitor cells. Laboratory and clinical studies.
Leukemia 1992;6 Suppl 4():38-40.
1992: K Miyazawa; P C Hendrie; Young-June Kim; Charlie Mantel; YC Yang; Byoung S Kwon; Hal E Broxmeyer
Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel factor to stimulate proliferation of the human factor-dependent cell line, M07e.
Blood 1992;80(7):1685-92.
1992: L Lu; Z Zhou; B Wu; M Xiao; R N Shen; D E Williams; Y J Kim; B S Kwon; S Ruscetti; Hal E Broxmeyer
Influence of recombinant human interleukin (IL)-7 on disease progression in mice infected with Friend virus complex.
International journal of cancer. Journal international du cancer 1992;52(2):261-5.
1992: R Maze; Barbara Sherry; Byoung S Kwon; Anthony Cerami; Hal E Broxmeyer
Myelosuppressive effects in vivo of purified recombinant murine macrophage inflammatory protein-1 alpha.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):1004-9.
1992: Hal E Broxmeyer; Giao Hangoc; Scott Cooper; R C Ribeiro; V Graves; M Yoder; J Wagner; S Vadhan-Raj; L Benninger; P Rubinstein
Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4109-13.
1992: M Xiao; T Leemhuis; Hal E Broxmeyer; L Lu
Influence of combinations of cytokines on proliferation of isolated single cell-sorted human bone marrow hematopoietic progenitor cells in the absence and presence of serum.
Experimental hematology 1992;20(2):276-9.
1992: Hal E Broxmeyer
Suppressor cytokines and regulation of myelopoiesis. Biology and possible clinical uses.
The American journal of pediatric hematology/oncology 1992;14(1):22-30.
1992: Hal E Broxmeyer; Giao Hangoc; Scott Cooper
Clinical and biological aspects of human umbilical cord blood as a source of transplantable hematopoietic stem and progenitor cells.
Bone marrow transplantation 1992;9 Suppl 1():7-10.
1992: Hal E Broxmeyer; Scott Cooper; M Yoder; Giao Hangoc
Human umbilical cord blood as a source of transplantable hematopoietic stem and progenitor cells.
Current topics in microbiology and immunology 1992;177():195-204.
1991: Hal E Broxmeyer; Giao Hangoc; J R Zucali; A Mason; R Schwall; C Carow; Scott Cooper
Effects in vivo of purified recombinant human activin and erythropoietin in mice.
International journal of hematology 1991;54(6):447-54.
1991: Hal E Broxmeyer; R Maze; K Miyazawa; C Carow; P C Hendrie; Scott Cooper; Giao Hangoc; S Vadhan-Raj; L Lu
The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(12):480-7.
1991: K Miyazawa; P C Hendrie; Charlie Mantel; K Wood; L K Ashman; Hal E Broxmeyer
Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase.
Experimental hematology 1991;19(11):1110-23.
1991: C E Carow; Giao Hangoc; S H Cooper; D E Williams; Hal E Broxmeyer
Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential.
Blood 1991;78(9):2216-21.
1991: P C Hendrie; K Miyazawa; YC Yang; C D Langefeld; Hal E Broxmeyer
Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of the human factor-dependent cell line, M07e.
Experimental hematology 1991;19(10):1031-7.
1991: K O Oh; Z Zhou; K K Kim; H Samanta; M Fraser; Young-June Kim; Hal E Broxmeyer; Byoung S Kwon
Identification of cell surface receptors for murine macrophage inflammatory protein-1 alpha.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2978-83.
1991: Hal E Broxmeyer; Barbara Sherry; Scott Cooper; F W Ruscetti; D E Williams; paolo arosio; Byoung S Kwon; Anthony Cerami
Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2586-94.
1991: L Lu; R N Shen; Hal E Broxmeyer
In vivo effects of recombinant human interleukin 6, alone or in combination with local irradiation, on tumor growth in Lewis lung carcinoma-bearing mice.
International journal of cell cloning 1991;9(5):511-20.
1991: L Lu; R N Shen; S Z Zhou; B Wu; Y J Kim; Z H Lin; S Ruscetti; P Ralph; Hal E Broxmeyer
Efficacy of recombinant human macrophage colony-stimulating factor in combination with whole-body hyperthermia in the treatment of mice infected with the polycythemia-inducing strain of the Friend virus complex.
Experimental hematology 1991;19(8):804-9.
1991: Giao Hangoc; J H Frederik Falkenburg; Hal E Broxmeyer
Influence of T-lymphocytes and lactoferrin on the survival-promoting effects of IL-1 and IL-6 on human bone marrow granulocyte-macrophage and erythroid progenitor cells.
Experimental hematology 1991;19(7):697-703.
1991: J H Frederik Falkenburg; Maureen A Harrington; Roelof A de Paus; W K Walsh; R Daub; JE Landegent; Hal E Broxmeyer
Differential transcriptional and posttranscriptional regulation of gene expression of the colony-stimulating factors by interleukin-1 and fetal bovine serum in murine fibroblasts.
Blood 1991;78(3):658-65.
1991: Hal E Broxmeyer; L Lu; Giao Hangoc; Scott Cooper; P C Hendrie; J A Ledbetter; M Xiao; D E Williams; F W Shen
CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand).
The Journal of experimental medicine 1991;174(2):447-58.
1991: Maureen A Harrington; Howard J Edenberg; SB Saxman; L M Pedigo; R Daub; Hal E Broxmeyer
Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene.
Gene 1991;102(2):165-70.
1991: Hal E Broxmeyer; Scott Cooper; L Lu; Giao Hangoc; D Anderson; D Cosman; S D Lyman; D E Williams
Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells.
Blood 1991;77(10):2142-9.
1991: R N Shen; L Lu; Gen-Sheng Feng; J Miller; M W Taylor; Hal E Broxmeyer
Cure with low-dose total-body irradiation of the hematological disorder induced in mice with the Friend virus: possible mechanism involving interferon-gamma and interleukin-2.
Lymphokine and cytokine research 1991;10(1-2):105-9.
1991: L Lu; R N Shen; S Z Zhou; C Srivastava; M Harrington; K Miyazawa; B Wu; Z H Lin; S Ruscetti; Hal E Broxmeyer
Synergistic effect of human lactoferrin and recombinant murine interferon-gamma on disease progression in mice infected with the polycythemia-inducing strain of the Friend virus complex.
International journal of hematology 1991;54(2):117-24.
1991: R N Shen; L Lu; Maureen A Harrington; C Srivastava; Y J Kim; S Z Zhou; B Wu; S Ruscetti; Hal E Broxmeyer
Effect of split low dose total body irradiation on SFFV mRNA, genomic DNA and protein expression in mice infected with the Friend virus complex.
Leukemia 1991;5(3):225-9.
1991: R N Shen; N B Hornback; H Shidnia; B Wu; L Lu; Hal E Broxmeyer
Whole body hyperthermia: a potent radioprotector in vivo.
International journal of radiation oncology, biology, physics 1991;20(3):525-30.
1991: Hal E Broxmeyer; Scott Cooper; S Levi; paolo arosio
Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):770-4.
1991: Hal E Broxmeyer; Giao Hangoc; Scott Cooper; D Anderson; D Cosman; S D Lyman; D E Williams
Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells.
Experimental hematology 1991;19(2):143-6.
1991: C H Srivastava; T A Rado; D Bauerle; Hal E Broxmeyer
Regulation of human bone marrow lactoferrin and myeloperoxidase gene expression by tumor necrosis factor-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):1014-9.
1991: K Miyazawa; Charlie Mantel; L Lu; D C Morrison; Hal E Broxmeyer
Lactoferrin-lipopolysaccharide interactions. Effect on lactoferrin binding to monocyte/macrophage-differentiated HL-60 cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):723-9.
1991: L Lu; R N Shen; Z H Lin; S L Aukerman; P Ralph; Hal E Broxmeyer
Anti-tumor effects of recombinant human macrophage colony-stimulating factor, alone or in combination with local irradiation, in mice inoculated with Lewis lung carcinoma cells.
International journal of cancer. Journal international du cancer 1991;47(1):143-7.
1991: P Gentile; Hal E Broxmeyer
Interleukin-6 ablates the accessory cell-mediated suppressive effects of lactoferrin on human hematopoietic progenitor cell proliferation in vitro.
Annals of the New York Academy of Sciences 1991;628():74-83.
1991: Hal E Broxmeyer; D C Bicknell; Scott Cooper; G Sledge; D E Williams; Warren McGuire; T D Coates
Qualitative functional deficiency of affinity-purified lactoferrin from neutrophils of patients with chronic myelogenous leukemia, and lactoferrin/H-ferritin-cell interactions in a patient with lactoferrin-deficiency with normal numbers of circulating leukocytes.
Pathobiology : journal of immunopathology, molecular and cellular biology 1991;59(1):26-35.
1991: Hal E Broxmeyer; Charlie Mantel; P Gentile; C Srivastava; K Miyazawa; J R Zucali; T A Rado; S Levi; paolo arosio
Actions of H-subunit ferritin and lactoferrin as suppressor molecules of myelopoiesis in vitro and in vivo.
Current studies in hematology and blood transfusion 1991;(58):178-81.
1991: Hal E Broxmeyer
Self-renewal and migration of stem cells during embryonic and fetal hematopoiesis: important, but poorly understood events.
Blood cells 1991;17(2):282-6.
1991: Hal E Broxmeyer; J Kurtzberg; E Gluckman; A D Auerbach; G Douglas; Scott Cooper; J H Falkenburg; J Bard; E A Boyse
Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation.
Blood cells 1991;17(2):313-29.
1990: L Lu; Z H Lin; R N Shen; D J Warren; T Leemhuis; Hal E Broxmeyer
Influence of interleukins 3,5, and 6 on the growth of eosinophil progenitors in highly enriched human bone marrow in the absence of serum.
Experimental hematology 1990;18(11):1180-6.
1990: Hal E Broxmeyer; Barbara Sherry; L Lu; Scott Cooper; K O Oh; P Tekamp-Olson; Byoung S Kwon; Anthony Cerami
Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells.
Blood 1990;76(6):1110-6.
1990: Maureen A Harrington; J H Frederik Falkenburg; R Daub; Hal E Broxmeyer
Effect of myogenic and adipogenic differentiation on expression of colony-stimulating factor genes.
Molecular and cellular biology 1990;10(9):4948-52.
1990: R N Shen; L Lu; B Wu; H Shidnia; N B Hornback; Hal E Broxmeyer
Effects of interleukin 2 treatment combined with local hyperthermia in mice inoculated with Lewis lung carcinoma cells.
Cancer research 1990;50(16):5027-30.
1990: Hal E Broxmeyer; Scott Cooper; L Lu; M E Miller; C D Langefeld; P Ralph
Enhanced stimulation of human bone marrow macrophage colony formation in vitro by recombinant human macrophage colony-stimulating factor in agarose medium and at low oxygen tension.
Blood 1990;76(2):323-9.
1990: J H Frederik Falkenburg; Maureen A Harrington; W K Walsh; R Daub; Hal E Broxmeyer
Gene-expression and release of macrophage-colony stimulating factor in quiescent and proliferating fibroblasts. Effects of serum, fibroblast growth-promoting factors, and IL-1.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4657-62.
1990: Hal E Broxmeyer; E Gluckman; A Auerbach; G W Douglas; H Friedman; Scott Cooper; Giao Hangoc; J Kurtzberg; J Bard; E A Boyse
Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells.
International journal of cell cloning 1990;8 Suppl 1():76-89; discussion 89-91.
1989: Hal E Broxmeyer; Barbara Sherry; L Lu; Scott Cooper; C Carow; S D Wolpe; Anthony Cerami
Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells.
The Journal of experimental medicine 1989;170(5):1583-94.
1989: L Lu; Paolo Foa; Francesco Chillemi; R N Shen; Z H Lin; C Carow; Hal E Broxmeyer
Suppressive biological activity of a synthetic pentapeptide on highly enriched human and murine marrow hematopoietic progenitors: synergism with recombinant human tumor necrosis factor-alpha and interferon-gamma.
Experimental hematology 1989;17(9):935-41.
1989: K Geissler; M Harrington; C Srivastava; T Leemhuis; Guido Tricot; Hal E Broxmeyer
Effects of recombinant human colony stimulating factors (CSF) (granulocyte-macrophage CSF, granulocyte CSF, and CSF-1) on human monocyte/macrophage differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):140-6.
1989: Giao Hangoc; D E Williams; J H Frederik Falkenburg; Hal E Broxmeyer
Influence of IL-1 alpha and -1 beta on the survival of human bone marrow cells responding to hematopoietic colony-stimulating factors.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4329-34.
1989: Hal E Broxmeyer; Scott Cooper; S Vadhan-Raj
Cell cycle status of erythroid (BFU-E) progenitor cells from the bone marrows of patients on a clinical trial with purified recombinant human granulocyte-macrophage colony-stimulating factor.
Experimental hematology 1989;17(5):455-9.
1989: K Geissler; Guido Tricot; T Leemhuis; E Walker; Hal E Broxmeyer
Differentiation-inducing effect of recombinant human tumor necrosis factor alpha and gamma-interferon in vitro on blast cells from patients with acute myeloid leukemia and myeloid blast crisis of chronic myeloid leukemia.
Cancer research 1989;49(11):3057-62.
1989: Hal E Broxmeyer; G W Douglas; Giao Hangoc; Scott Cooper; J Bard; Denis English; M Arny; L Thomas; E A Boyse
Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3828-32.
1989: Hal E Broxmeyer; D E Williams; K Geissler; Giao Hangoc; Scott Cooper; D C Bicknell; S Levi; paolo arosio
Suppressive effects in vivo of purified recombinant human H-subunit (acidic) ferritin on murine myelopoiesis.
Blood 1989;73(1):74-9.
1989: Hal E Broxmeyer; Scott Cooper; T Gabig
The effects of oxidizing species derived from molecular oxygen on the proliferation in vitro of human granulocyte-macrophage progenitor cells.
Annals of the New York Academy of Sciences 1989;554():177-84.
1989: Hal E Broxmeyer; S Vadhan-Raj
Preclinical and clinical studies with the hematopoietic colony-stimulating factors and related interleukins.
Immunologic research 1989;8(3):185-201.
1989: R N Shen; N B Hornback; L Lu; L T Chen; Youri A Serov; Hal E Broxmeyer
Low dose total body irradiation: a potent anti-retroviral agent in vivo.
International journal of radiation oncology, biology, physics 1989;16(1):165-70.
1989: Hal E Broxmeyer; K Geissler; Scott Cooper; D E Williams
Influence of purified recombinant human macrophage colony stimulating factor in mice.
Biotechnology therapeutics 1989;1(1):43-54.
1989: Giao Hangoc; Hal E Broxmeyer
Effects of purified recombinant human interleukin-3 on the growth of human hematopoietic progenitor cells in "long-term" bone marrow culture.
Biotechnology therapeutics 1989;1(1):17-29.
1988: Hal E Broxmeyer; L Lu; Scott Cooper; R H Schwall; A J Mason; K Nikolics
Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9052-6.
1988: Hal E Broxmeyer; L Lu; Scott Cooper; R Tushinski; D Mochizuki; B Y Rubin; S Gillis; D E Williams
Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3852-62.
1988: D E Williams; Hal E Broxmeyer
Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony-stimulating factors.
Blood 1988;72(5):1608-15.
1988: Denis English; Hal E Broxmeyer; T G Gabig; L P Akard; D E Williams; R Hoffman
Temporal adaptation of neutrophil oxidative responsiveness to n-formyl-methionyl-leucyl-phenylalanine. Acceleration by granulocyte-macrophage colony stimulating factor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(7):2400-6.
1988: Hal E Broxmeyer; D E Williams; Scott Cooper; Giao Hangoc; P Ralph
Recombinant human granulocyte-colony stimulating factor and recombinant human macrophage-colony stimulating factor synergize in vivo to enhance proliferation of granulocyte-macrophage, erythroid, and multipotential progenitor cells in mice.
Journal of cellular biochemistry 1988;38(2):127-36.
1988: R N Shen; N B Hornback; H Shidnia; L Lu; Hal E Broxmeyer; Zacharie Brahmi
Effect of whole-body hyperthermia and cyclophosphamide on natural killer cell activity in murine erythroleukemia.
Cancer research 1988;48(16):4561-3.
1988: Hal E Broxmeyer; D E Williams; Scott Cooper; P Ralph; S Gillis; D C Bicknell; Giao Hangoc; R Drummond; L Lu
Synergistic interaction of hematopoietic colony stimulating and growth factors in the regulation of myelopoiesis.
Behring Institute Mitteilungen 1988;(83):80-4.
1988: Hal E Broxmeyer; Scott Cooper; D E Williams; Giao Hangoc; J U Gutterman; S Vadhan-Raj
Growth characteristics of marrow hematopoietic progenitor/precursor cells from patients on a phase I clinical trial with purified recombinant human granulocyte-macrophage colony-stimulating factor.
Experimental hematology 1988;16(7):594-602.
1988: L Lu; D Walker; C D Graham; A Waheed; R K Shadduck; Hal E Broxmeyer
Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor necrosis factor-alpha: synergism with recombinant human interferon-gamma.
Blood 1988;72(1):34-41.
1988: L Lu; Edward F Srour; D J Warren; D Walker; C D Graham; E B Walker; J Jansen; Hal E Broxmeyer
Enhancement of release of granulocyte- and granulocyte-macrophage colony-stimulating factors from phytohemagglutinin-stimulated sorted subsets of human T lymphocytes by recombinant human tumor necrosis factor-alpha. Synergism with recombinant human IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):201-7.
1988: R N Shen; N B Hornback; L Lu; P Young; Youri A Serov; Hal E Broxmeyer
Curative effect of split low dosage total-body irradiation on mice infected with the polycythemia-inducing strain of the Friend virus complex.
Cancer research 1988;48(9):2399-403.
1988: D E Williams; S Cooper; Hal E Broxmeyer
Effects of hematopoietic suppressor molecules on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells.
Cancer research 1988;48(6):1548-50.
1988: D C Bicknell; D E Williams; Hal E Broxmeyer
Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM).
Experimental hematology 1988;16(3):240-3.
1988: Hal E Broxmeyer; S Vadhan-Raj; Giao Hangoc; L Lu; J U Gutterman; D E Williams
Preclinical and clinical effects of the hematopoietic colony stimulating factors.
Advances in experimental medicine and biology 1988;241():233-41.
1988: Hal E Broxmeyer; D E Williams
The production of myeloid blood cells and their regulation during health and disease.
Critical reviews in oncology/hematology 1988;8(3):173-226.
1988: D E Williams; D C Bicknell; L S Park; J E Straneva; Scott Cooper; Hal E Broxmeyer
Purified murine granulocyte/macrophage progenitor cells express a high-affinity receptor for recombinant murine granulocyte/macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):487-91.
1988: D C Bicknell; D E Williams; Hal E Broxmeyer
Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM).
Experimental hematology 1988;16(1):88-91.
1987: Giao Hangoc; L Lu; A Oliff; S Gillis; W Hu; D C Bicknell; D Williams; Hal E Broxmeyer
Modulation of Friend virus infectivity in vivo by administration of purified preparations of human lactoferrin and recombinant murine interleukin-3 to mice.
Leukemia 1987;1(11):762-4.
1987: D E Williams; J E Straneva; Scott Cooper; R K Shadduck; A Waheed; S Gillis; D Urdal; Hal E Broxmeyer
Interactions between purified murine colony-stimulating factors (natural CSF-1, recombinant GM-CSF, and recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells.
Experimental hematology 1987;15(10):1007-12.
1987: Hal E Broxmeyer; D E Williams; Giao Hangoc; Scott Cooper; S Gillis; R K Shadduck; D C Bicknell
Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(11):3871-5.
1987: Hal E Broxmeyer; D E Williams; Giao Hangoc; Scott Cooper; P Gentile; R N Shen; P Ralph; S Gillis; D C Bicknell
The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors.
Blood cells 1987;13(1-2):31-48.
1987: D E Williams; L Lu; Hal E Broxmeyer
Characterization of hematopoietic stem and progenitor cells.
Immunologic research 1987;6(4):294-304.
1987: Hal E Broxmeyer; D E Williams
Actions of hematopoietic colony-stimulating factors in vivo and in vitro.
Pathology and immunopathology research 1987;6(3):207-20.