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George Broze

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Chemicals & Drugs

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Publications

TOP 3
T J Girard; Nina Lasky; Elodee A Tuley; George J Broze
Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
Xin Huang; George J Broze; Jeffrey Gatti; Yizheng Tu; Yahui Yan; Aiwu Zhou; Steven T Olson
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Thomas J Girard; Elodee Tuley; George J Broze
TFPIβ is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes.

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All Publications

2013: T J Girard; Nina Lasky; Elodee A Tuley; George J Broze
Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
Journal of thrombosis and haemostasis : JTH 2013;11(2):375-8.
2012: Xin Huang; George J Broze; Jeffrey Gatti; Yizheng Tu; Yahui Yan; Aiwu Zhou; Steven T Olson
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
Blood 2012;120(8):1726-33.
2012: Thomas J Girard; Elodee Tuley; George J Broze
TFPIβ is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes.
Blood 2012;119(5):1256-62.
2011: Matthew Ndonwi; Douglas M Tollefsen; George J Broze; Oname O Burlingame; Aaron S Miller; Daniel E Goldberg
Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.
Blood 2011;117(23):6347-54.
2011: Xin Huang; Alireza R Rezaie; George J Broze; Steven T Olson
Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor.
The Journal of biological chemistry 2011;286(11):8740-51.
2010: Matthew Ndonwi; Elodee A Tuley; George J Broze
The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition.
Blood 2010;116(8):1344-51.
2010: George J Broze; Y Tu
Protein Z and protein Z-dependent protease inhibitor and renal tubules.
Thrombosis and haemostasis 2010;103(2):473-4.
2008: Xin Huang; Richard Swanson; George J Broze; Steven T Olson
Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa.
The Journal of biological chemistry 2008;283(44):29770-83.
2008: Jing Zhang; Yizheng Tu; Lan Lu; Nina Lasky; George J Broze
Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Blood 2008;111(10):4973-8.
2007: Matthew Ndonwi; George J Broze; Sayeh Agah; Amy E Schmidt; S Paul Bajaj
Substitution of the Gla domain in factor X with that of protein C impairs its interaction with factor VIIa/tissue factor: lack of comparable effect by similar substitution in factor IX.
The Journal of biological chemistry 2007;282(21):15632-44.
2006: Hajime Fujimoto; Esteban C Gabazza; Osamu Taguchi; Yoichi Nishii; Hiroki Nakahara; Nelson E Bruno; Corina N D'Alessandro-Gabazza; Michael Kasper; Yutaka Yano; Mariko Nagashima; John Morser; George J Broze; Koji Suzuki; Yukihiko Adachi
Thrombin-activatable fibrinolysis inhibitor deficiency attenuates bleomycin-induced lung fibrosis.
The American journal of pathology 2006;168(4):1086-96.
2006: Tongyao Liu; Ciaran D Scallan; George J Broze; Susannah Patarroyo-White; Glenn F Pierce; Kirk W Johnson
Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP).
Thrombosis and haemostasis 2006;95(1):68-76.
2005: Orlando Piro; George J Broze
Comparison of cell-surface TFPIalpha and beta.
Journal of thrombosis and haemostasis : JTH 2005;3(12):2677-83.
2005: Ali Al-Shanqeeti; Astrid van Hylckama Vlieg; Erik Berntorp; Frits R Rosendaal; George J Broze
Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.
Thrombosis and haemostasis 2005;93(3):411-3.
2005: M Ndonwi; George J Broze; S Paul Bajaj
The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex.
Journal of thrombosis and haemostasis : JTH 2005;3(1):112-8.
2004: Orlando Piro; George J Broze
Role for the Kunitz-3 domain of tissue factor pathway inhibitor-alpha in cell surface binding.
Circulation 2004;110(23):3567-72.
2004: Genmin Lu; George J Broze; Senthil Kumar Krishnaswamy
Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.
The Journal of biological chemistry 2004;279(17):17241-9.
2003: Jing Zhang; Orlando Piro; Lan Lu; George J Broze
Glycosyl phosphatidylinositol anchorage of tissue factor pathway inhibitor.
Circulation 2003;108(5):623-7.
2002: Daniel T Eitzman; Randal J Westrick; Xiaoming Bi; Sara L Manning; John Wilkinson; George J Broze; David Ginsburg
Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden.
Circulation 2002;105(18):2139-42.
2002: Mariko Nagashima; Zheng-Feng Yin; George J Broze; John Morser
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice.
Frontiers in bioscience : a journal and virtual library 2002;7():d556-68.
2002: Mariko Nagashima; Zheng-Feng Yin; Lei Zhao; Kathy White; Yanhong Zhu; Nina Lasky; Meredith Halks-Miller; George J Broze; William P Fay; John Morser
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.
The Journal of clinical investigation 2002;109(1):101-10.
2001: George J Broze
Protein Z-dependent regulation of coagulation.
Thrombosis and haemostasis 2001;86(1):8-13.
2001: Randal J Westrick; Peter F Bodary; Z Xu; Y C Shen; George J Broze; Daniel T Eitzman
Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.
Circulation 2001;103(25):3044-6.
2001: J Zhang; George J Broze
Mouse protein Z-dependent protease inhibitor cDNA.
Thrombosis and haemostasis 2001;85(5):861-5.
2001: George J Broze; Zheng-Feng Yin; Nina Lasky
A tail vein bleeding time model and delayed bleeding in hemophiliac mice.
Thrombosis and haemostasis 2001;85(4):747-8.
2001: A Tabatabai; R Fiehler; George J Broze
Protein Z circulates in plasma in a complex with protein Z-dependent protease inhibitor.
Thrombosis and haemostasis 2001;85(4):655-60.
2000: X Han; R Fiehler; George J Broze
Characterization of the protein Z-dependent protease inhibitor.
Blood 2000;96(9):3049-55.
2000: Zheng-Feng Yin; ZF Huang; J Cui; R Fiehler; Nina Lasky; David Ginsburg; George J Broze
Prothrombotic phenotype of protein Z deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6734-8.
2000: G Ho; M Narita; George J Broze; Alan L Schwartz
Recombinant full-length tissue factor pathway inhibitor fails to bind to the cell surface: implications for catabolism in vitro and in vivo.
Blood 2000;95(6):1973-8.
1999: X Han; ZF Huang; R Fiehler; George J Broze
The protein Z-dependent protease inhibitor is a serpin.
Biochemistry 1999;38(34):11073-8.
1999: JC Chan; Peter Carmeliet; Lieve Moons; Elliot D Rosen; ZF Huang; George J Broze; Désiré Collen; Francis J Castellino
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit.
The Journal of clinical investigation 1999;103(4):475-82.
1998: X Han; R Fiehler; George J Broze
Isolation of a protein Z-dependent plasma protease inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9250-5.
1998: George J Broze
Tissue factor pathway inhibitor gene disruption.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9 Suppl 1():S89-92.
1998: R J Baugh; George J Broze; Senthil Kumar Krishnaswamy
Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor.
The Journal of biological chemistry 1998;273(8):4378-86.
1997: A E Mast; D A Higuchi; ZF Huang; I Warshawsky; Alan L Schwartz; George J Broze
Glypican-3 is a binding protein on the HepG2 cell surface for tissue factor pathway inhibitor.
The Biochemical journal 1997;327 ( Pt 2)():577-83.
1997: Alan L Schwartz; George J Broze
Tissue factor pathway inhibitor endocytosis.
Trends in cardiovascular medicine 1997;7(7):234-9.
1997: ZF Huang; D Higuchi; Nina Lasky; George J Broze
Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice.
Blood 1997;90(3):944-51.
1997: G Ho; George J Broze; Alan L Schwartz
Role of heparan sulfate proteoglycans in the uptake and degradation of tissue factor pathway inhibitor-coagulation factor Xa complexes.
The Journal of biological chemistry 1997;272(27):16838-44.
1997: Z F Huang; George J Broze
Consequences of tissue factor pathway inhibitor gene-disruption in mice.
Thrombosis and haemostasis 1997;78(1):699-704.
1997: J R Toomey; K E Kratzer; Nina Lasky; George J Broze
Effect of tissue factor deficiency on mouse and tumor development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6922-6.
1997: David Gailani; Nina Lasky; George J Broze
A murine model of factor XI deficiency.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8(2):134-44.
1996: George J Broze; D A Higuchi
Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.
Blood 1996;88(10):3815-23.
1996: I Warshawsky; Joachim Herz; George J Broze; Alan L Schwartz
The low density lipoprotein receptor-related protein can function independently from heparan sulfate proteoglycans in tissue factor pathway inhibitor endocytosis.
The Journal of biological chemistry 1996;271(42):25873-9.
1996: J R Toomey; K E Kratzer; Nina Lasky; J J Stanton; George J Broze
Targeted disruption of the murine tissue factor gene results in embryonic lethality.
Blood 1996;88(5):1583-7.
1996: G Ho; J R Toomey; George J Broze; Alan L Schwartz
Receptor-mediated endocytosis of coagulation factor Xa requires cell surface-bound tissue factor pathway inhibitor.
The Journal of biological chemistry 1996;271(16):9497-502.
1996: A E Mast; George J Broze
Physiological concentrations of tissue factor pathway inhibitor do not inhibit prothrombinase.
Blood 1996;87(5):1845-50.
1995: M Narita; Guojun Bu; G M Olins; D A Higuchi; Joachim Herz; George J Broze; Alan L Schwartz
Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo.
The Journal of biological chemistry 1995;270(42):24800-4.
1995: George J Broze
Tissue factor pathway inhibitor and the current concept of blood coagulation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6 Suppl 1():S7-13.
1995: I Warshawsky; Guojun Bu; A Mast; J E Saffitz; George J Broze; Alan L Schwartz
The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo.
The Journal of clinical investigation 1995;95(4):1773-81.
1995: George J Broze
Tissue factor pathway inhibitor and the revised theory of coagulation.
Annual review of medicine 1995;46():103-12.
1994: T J Girard; David Gailani; George J Broze
Complementary DNA sequencing of canine tissue factor pathway inhibitor reveals a unique nanomeric repetitive sequence between the second and third Kunitz domains.
The Biochemical journal 1994;303 ( Pt 3)():923-8.
1994: George J Broze; G W Lange; K L Duffin; L MacPhail
Heterogeneity of plasma tissue factor pathway inhibitor.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):551-9.
1994: I Warshawsky; George J Broze; Alan L Schwartz
The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6664-8.
1993: ZF Huang; T C Wun; George J Broze
Kinetics of factor Xa inhibition by tissue factor pathway inhibitor.
The Journal of biological chemistry 1993;268(36):26950-5.
1993: Robin Wesselschmidt; K Likert; Z Huang; L MacPhail; George J Broze
Structural requirements for tissue factor pathway inhibitor interactions with factor Xa and heparin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(5):661-9.
1993: George J Broze; K Likert; D Higuchi
Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor.
Blood 1993;82(5):1679-81.
1993: David Gailani; George J Broze
Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.
Blood 1993;82(3):813-9.
1993: George J Broze; David Gailani
The role of factor XI in coagulation.
Thrombosis and haemostasis 1993;70(1):72-4.
1993: David Gailani; George J Broze
Effects of glycosaminoglycans on factor XI activation by thrombin.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(1):15-20.
1993: T J Girard; George J Broze
Tissue factor pathway inhibitor.
Methods in enzymology 1993;222():195-209.
1993: David Gailani; George J Broze
Factor XI activation by thrombin and factor XIa.
Seminars in thrombosis and hemostasis 1993;19(4):396-404.
1992: R P Smith; George J Broze
Characterization of platelet-releasable forms of beta-amyloid precursor proteins: the effect of thrombin.
Blood 1992;80(9):2252-60.
1992: George J Broze
The role of tissue factor pathway inhibitor in a revised coagulation cascade.
Seminars in hematology 1992;29(3):159-69.
1992: Robin Wesselschmidt; K Likert; T Girard; T C Wun; George J Broze
Tissue factor pathway inhibitor: the carboxy-terminus is required for optimal inhibition of factor Xa.
Blood 1992;79(8):2004-10.
1992: D A Higuchi; T C Wun; K M Likert; George J Broze
The effect of leukocyte elastase on tissue factor pathway inhibitor.
Blood 1992;79(7):1712-9.
1992: George J Broze
Tissue factor pathway inhibitor and the revised hypothesis of blood coagulation.
Trends in cardiovascular medicine 1992;2(2):72-7.
1992: George J Broze; Robin Wesselschmidt; D Higuchi; T Girard; K Likert; L MacPhail; T C Wun
The interaction between LACI and heparin.
Advances in experimental medicine and biology 1992;313():189-97.
1991: Steven D Carson; William D Haire; George J Broze; W F Novotny; S J Pirrucello; M J Duggan
Lipoprotein associated coagulation inhibitor, factor VII, antithrombin III, and monocyte tissue factor following surgery.
Thrombosis and haemostasis 1991;66(5):534-9.
1991: David Gailani; George J Broze
Factor XI activation in a revised model of blood coagulation.
Science (New York, N.Y.) 1991;253(5022):909-12.
1991: W F Novotny; M Palmier; T C Wun; George J Broze; J P Miletich
Purification and properties of heparin-releasable lipoprotein-associated coagulation inhibitor.
Blood 1991;78(2):394-400.
1991: W F Novotny; S G Brown; J P Miletich; D J Rader; George J Broze
Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples.
Blood 1991;78(2):387-93.
1991: T J Girard; R Eddy; Robin Wesselschmidt; L A MacPhail; K M Likert; M G Byers; T B Shows; George J Broze
Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2.
The Journal of biological chemistry 1991;266(8):5036-41.
1991: George J Broze; T J Girard; W F Novotny
The lipoprotein-associated coagulation inhibitor.
Progress in hemostasis and thrombosis 1991;10():243-68.
1991: George J Broze; T J Girard; W F Novotny
Lipoprotein-associated coagulation inhibitor.
Current studies in hematology and blood transfusion 1991;(58):22-5.
1990: Robin Wesselschmidt; T J Girard; George J Broze
cDNA sequence of rabbit lipoprotein-associated coagulation inhibitor.
Nucleic acids research 1990;18(21):6440.
1990: K C Day; L C Hoffman; Mark Palmier; K K Kretzmer; M D Huang; E Y Pyla; E Spokas; George J Broze; T G Warren; T C Wun
Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit.
Blood 1990;76(8):1538-45.
1990: T C Wun; M D Huang; K K Kretzmer; Mark Palmier; K C Day; J W Bulock; K F Fok; George J Broze
Immunoaffinity purification and characterization of lipoprotein-associated coagulation inhibitors from Hep G2 hepatoma, Chang liver, and SK hepatoma cells. A comparative study.
The Journal of biological chemistry 1990;265(27):16096-101.
1990: T J Girard; D McCourt; W F Novotny; L A MacPhail; K M Likert; George J Broze
Endogenous phosphorylation of the lipoprotein-associated coagulation inhibitor at serine-2.
The Biochemical journal 1990;270(3):621-5.
1990: George J Broze; T J Girard; W F Novotny
Regulation of coagulation by a multivalent Kunitz-type inhibitor.
Biochemistry 1990;29(33):7539-46.
1990: T J Girard; L A MacPhail; K M Likert; W F Novotny; J P Miletich; George J Broze
Inhibition of factor VIIa-tissue factor coagulation activity by a hybrid protein.
Science (New York, N.Y.) 1990;248(4961):1421-4.
1990: R P Smith; D A Higuchi; George J Broze
Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein.
Science (New York, N.Y.) 1990;248(4959):1126-8.
1989: W F Novotny; T J Girard; J P Miletich; George J Broze
Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma.
The Journal of biological chemistry 1989;264(31):18832-7.
1989: T J Girard; L A Warren; W F Novotny; B E Bejcek; J P Miletich; George J Broze
Identification of the 1.4 kb and 4.0 kb messages for the lipoprotein associated coagulation inhibitor and expression of the encoded protein.
Thrombosis research 1989;55(1):37-50.
1989: T J Girard; L A Warren; W F Novotny; K M Likert; S G Brown; J P Miletich; George J Broze
Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor.
Nature 1989;338(6215):518-20.
1988: W F Novotny; T J Girard; J P Miletich; George J Broze
Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor.
Blood 1988;72(6):2020-5.
1988: T C Wun; K K Kretzmer; T J Girard; J P Miletich; George J Broze
Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.
The Journal of biological chemistry 1988;263(13):6001-4.
1988: George J Broze; L A Warren; W F Novotny; D A Higuchi; J J Girard; J P Miletich
The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action.
Blood 1988;71(2):335-43.
1987: George J Broze; L A Warren; J J Girard; J P Miletich
Isolation of the lipoprotein associated coagulation inhibitor produced by HepG2 (human hepatoma) cells using bovine factor Xa affinity chromatography.
Thrombosis research 1987;48(2):253-9.