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Bruno Guigas

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Wilco W M Fleuren; Bruno Guigas; Margot M L Linssen; D Margriet Ouwens; Erik J M Toonen; Gerard C M van der Zon; Jacob de Vlieg; Wim H A Dokter; Wynand Alkema
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.
Willemijn M Passtoors; Graham Pawelec; Ruud van der Breggen; Diana van Heemst; Marian Beekman; Anton J M de Craen; Joris Deelen; Evelyna Derhovanessian; Bruno Guigas; David A Gunn; Andrea B Maier; Pieternella E Slagboom
Gene expression analysis of mTOR pathway: association with human longevity.
N van Leeuwen; E van 't Riet; K Zhou; P E Slagboom; B H C Stricker; L M 't Hart; A G Uitterlinden; M L Becker; R A Calle; H Colhoun; Jacqueline M Dekker; H Deshmukh; P Durrington; Bruno Guigas; G Hitman; Albert Hofman; R R Holman; S J Livingstone; M I McCarthy; A Neil; Giel Nijpels; C N A Palmer; E R Pearson
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

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All Publications

2013: Wilco W M Fleuren; Bruno Guigas; Margot M L Linssen; D Margriet Ouwens; Erik J M Toonen; Gerard C M van der Zon; Jacob de Vlieg; Wim H A Dokter; Wynand Alkema
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.
Archives of physiology and biochemistry 2013;119(2):52-64.
2013: Willemijn M Passtoors; Graham Pawelec; Ruud van der Breggen; Diana van Heemst; Marian Beekman; Anton J M de Craen; Joris Deelen; Evelyna Derhovanessian; Bruno Guigas; David A Gunn; Andrea B Maier; Pieternella E Slagboom
Gene expression analysis of mTOR pathway: association with human longevity.
Aging cell 2013;12(1):24-31.
2012: N van Leeuwen; E van 't Riet; K Zhou; P E Slagboom; B H C Stricker; L M 't Hart; A G Uitterlinden; M L Becker; R A Calle; H Colhoun; Jacqueline M Dekker; H Deshmukh; P Durrington; Bruno Guigas; G Hitman; Albert Hofman; R R Holman; S J Livingstone; M I McCarthy; A Neil; Giel Nijpels; C N A Palmer; E R Pearson
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
Diabetologia 2012;55(7):1971-7.
2012: Laurent Bultot; Marc Foretz; Bruno Guigas; Joan J Guinovart; Louis Hue; Nusrat Hussain; Liliane Maisin; Kei Sakamoto; Didier Vertommen; Benoit Viollet; Alexander Von Wilamowitz-Moellendorff; Monique Beullens; Mark H Rider
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.
The Biochemical journal 2012;443(1):193-203.
2012: Benoit Viollet; Marc Foretz; Bruno Guigas; Jocelyne Leclerc; Nieves Sanz Garcia; Fabrizio Andreelli
Cellular and molecular mechanisms of metformin: an overview.
Clinical science (London, England : 1979) 2012;122(6):253-70.
2012: Man C Wong; Hetty C de Boer; Bruno Guigas; Louis M Havekes; Pieter S Hiemstra; Lihui Hu; Johan Kuiper; Patrick C N Rensen; Johannes A Romijn; Steven E Shoelson; Jouke T Tamsma; Janna A van Diepen; Gijs H van Puijvelde; Anton-Jan van Zonneveld; Peter J Voshol; Jimmy F P Berbée
Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.
Atherosclerosis 2012;220(2):362-8.
2011: Claudia P Coomans; Janine J Geerling; Bruno Guigas; Louis M Havekes; Patrick C N Rensen; Nienke R Biermasz; Johannes A Romijn
Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice.
Diabetes 2011;60(12):3132-40.
2011: Xavier Stephenne; Nellie Taleux; Gerard C M van der Zon; Benoit Viollet; Marc Foretz; Louis Hue; Etienne Sokal; Bruno Guigas
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.
Diabetologia 2011;54(12):3101-10.
2011: Margot M L Linssen; Erik J M Toonen; Gerard C M van der Zon; Daniel H van Raalte; Wynand Alkema; Michaela Diamant; Wim H Dokter; Bruno Guigas; D Margriet Ouwens
Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells.
Cellular signalling 2011;23(11):1708-15.
2011: Claudia P Coomans; Janine J Geerling; Bruno Guigas; Louis M Havekes; D Margriet Ouwens; Edwin T Parlevliet; Hanno Pijl; Patrick C N Rensen; Anita M van den Hoek; Peter J Voshol; Johannes A Romijn
Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice.
Journal of lipid research 2011;52(9):1712-22.
2011: Janna A van Diepen; Man C Wong; Bruno Guigas; Jasper Bos; Rinke Stienstra; Leanne Hodson; Steven E Shoelson; Jimmy F P Berbée; Patrick C N Rensen; Johannes A Romijn; Louis M Havekes; Peter J Voshol
Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice.
Journal of lipid research 2011;52(5):942-50.
2010: J E de Leeuw van Weenen; E T Parlevliet; Pierre Maechler; Louis M Havekes; Johannes A Romijn; D Margriet Ouwens; Hanno Pijl; Bruno Guigas
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.
Biochemical pharmacology 2010;79(12):1827-36.
2010: Emmani B M Nascimento; Marieke Snel; Bruno Guigas; Gerard C M van der Zon; Jan Kriek; J Antonie Maassen; Ingrid M Jazet; Michaela Diamant; D Margriet Ouwens
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Cellular signalling 2010;22(6):961-7.
2010: Alain da Silva Morais; Jorge Abarca-Quinones; Bruno Guigas; Benoit Viollet; Peter Stärkel; yves horsmans; Isabelle Leclercq
Development of hepatic fibrosis occurs normally in AMPK-deficient mice.
Clinical science (London, England : 1979) 2010;118(6):411-20.
2010: Sjoerd van den Berg; Bruno Guigas; Silvia Bijland; Margriet Ouwens; Peter J Voshol; Rune R Frants; Louis M Havekes; Johannes A Romijn; Ko Willems van Dijk
High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity.
Nutrition & metabolism 2010;7():24.
2009: B Viollet; Bruno Guigas; J Leclerc; S Hébrard; L Lantier; R Mounier; Fabrizio Andreelli; Marc Foretz
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.
Acta physiologica (Oxford, England) 2009;196(1):81-98.
2009: Alain Da Silva Morais; Valérie Lebrun; Jorge Abarca-Quinones; Sonia Brichard; Louis Hue; Bruno Guigas; Benoit Viollet; Isabelle Leclercq
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
Journal of hepatology 2009;50(3):489-500.
2009: Nellie Taleux; Bruno Guigas; Hervé Dubouchaud; Maria Moreno; Joachim M Weitzel; Fernando Goglia; Roland Favier; Xavier M Leverve
High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity.
The Journal of biological chemistry 2009;284(7):4308-16.
2009: Benoit Viollet; Yoni Athea; Remi Mounier; Bruno Guigas; Elham Zarrinpashneh; Sandrine Horman; Louise Lantier; Sophie Hebrard; Jocelyne Devin-Leclerc; Christophe Beauloye; Marc Foretz; Fabrizio Andreelli; Renée Ventura-Clapier; Luc Bertrand
AMPK: Lessons from transgenic and knockout animals.
Frontiers in bioscience : a journal and virtual library 2009;14():19-44.
2009: Bruno Guigas; Kei Sakamoto; Nellie Taleux; Sara M Reyna; Nicolas Musi; Benoit Viollet; Louis Hue
Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.
IUBMB life 2009;61(1):18-26.
2008: G Lacraz; Karine Couturier; N Taleux; Stéphane Servais; Brigitte Sibille; Dominique Letexier; Bruno Guigas; H Dubouchaud; Xavier Leverve; Roland Favier
Liver mitochondrial properties from the obesity-resistant Lou/C rat.
International journal of obesity (2005) 2008;32(4):629-38.
2008: Nellie Taleux; I De Potter; C Deransart; G Lacraz; Roland Favier; Xavier M Leverve; Louis Hue; Bruno Guigas
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity.
International journal of obesity (2005) 2008;32(4):639-47.
2008: Bruno Guigas
No lack of contraction-induced AMPK activation and glucose uptake in fast-twitch muscles from adenylate kinase-1 knockout mice.
Acta physiologica (Oxford, England) 2008;192(3):337.
2008: Mohamad Y El-Mir; Dominique Detaille; Gloria R-Villanueva; María Delgado-Esteban; Bruno Guigas; Stephane Attia; Eric Fontaine; Angeles Almeida; Xavier Leverve
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.
Journal of molecular neuroscience : MN 2008;34(1):77-87.
2007: David Kitz Krämer; Lubna Al-Khalili; Bruno Guigas; Ying Leng; Pablo M Garcia-Roves; Anna Krook
Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
The Journal of biological chemistry 2007;282(27):19313-20.
2007: Bruno Guigas; Nellie Taleux; Marc Foretz; Dominique Detaille; Fabrizio Andreelli; Benoit Viollet; Louis Hue
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.
The Biochemical journal 2007;404(3):499-507.
2007: Bruno Guigas; Roula Naboulsi; Gloria R Villanueva; Nellie Taleux; José Lopez-Novoa; Xavier M Leverve; Mohamad Y El-Mir
The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):925-34.
2007: Xavier Stéphenne; Mustapha Najimi; Dung Khuu Ngoc; Françoise Smets; Louis Hue; Bruno Guigas; Etienne M Sokal
Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1.
Cell transplantation 2007;16(4):409-19.
2006: Benoit Viollet; Marc Foretz; Bruno Guigas; Sandrine Horman; Renaud Dentin; Luc Bertrand; Louis Hue; Fabrizio Andreelli
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
The Journal of physiology 2006;574(Pt 1):41-53.
2006: Luc Bertrand; Audrey Ginion; Christophe Beauloye; Alexandre D Hebert; Bruno Guigas; Louis Hue; Jean-Louis J Vanoverschelde
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H239-50.
2006: Marc Foretz; Nellie Taleux; Bruno Guigas; Sandrine Horman; Christophe Beauloye; Fabrizio Andreelli; Luc Bertrand; Benoit Viollet
[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].
Médecine sciences : M/S 2006;22(4):381-8.
2006: Marc Foretz; Bruno Guigas; Benoit Viollet
[From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target].
Médecine sciences : M/S 2006;22(4):348-50.
2006: Bruno Guigas; Luc Bertrand; Nellie Taleux; Marc Foretz; Nicolas Wiernsperger; Didier Vertommen; Fabrizio Andreelli; Benoit Viollet; Louis Hue
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.
Diabetes 2006;55(4):865-74.
2006: Cécile Batandier; Bruno Guigas; Dominique Detaille; Mohamad Y El-Mir; Eric Fontaine; Michel Rigoulet; Xavier M Leverve
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.
Journal of bioenergetics and biomembranes 2006;38(1):33-42.
2005: Lionel Gresh; Brigitte Bourachot; Andreas Reimann; Bruno Guigas; Laurence Fiette; Serge Garbay; Christian Muchardt; Louis Hue; Marco Pontoglio; Moshe Yaniv; Agnès Klochendler-Yeivin
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation.
The EMBO journal 2005;24(18):3313-24.
2005: Dominique Detaille; Bruno Guigas; Christiane Chauvin; Cécile Batandier; Eric Fontaine; Nicolas Wiernsperger; Xavier Leverve
Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.
Diabetes 2005;54(7):2179-87.
2004: Olivier Bocqueraz; Nathalie Koulmann; Bruno Guigas; Chantal Jimenez; Bruno Melin
Fluid-regulatory hormone responses during cycling exercise in acute hypobaric hypoxia.
Medicine and science in sports and exercise 2004;36(10):1730-6.
2004: Bruno Guigas; Dominique Detaille; Christiane Chauvin; Cécile Batandier; Frédéric De Oliveira; Eric Fontaine; Xavier Leverve
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.
The Biochemical journal 2004;382(Pt 3):877-84.
2004: Karine Couturier; Stéphane Servais; Harry Koubi; Brigitte Sempore; Jean-Marie Cottet-Emard; Bruno Guigas; Jean-Marc Lavoie; Roland Favier
Metabolic and hormonal responses to exercise in the anti-obese Lou/C rats.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(8):972-8.
2003: Xavier M Leverve; Bruno Guigas; Dominique Detaille; Cécile Batandier; E A Koceir; Christiane Chauvin; Eric Fontaine; Nicolas Wiernsperger
Mitochondrial metabolism and type-2 diabetes: a specific target of metformin.
Diabetes & metabolism 2003;29(4 Pt 2):6S88-94.
2002: Dominique Detaille; Bruno Guigas; Xavier Leverve; Nicolas Wiernsperger; Pierre Devos
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function.
Biochemical pharmacology 2002;63(7):1259-72.
2001: Carole Ichai; Ludovic Guignot; Mohamad Y El-Mir; Véronique Nogueira; Bruno Guigas; Christiane Chauvin; Eric Fontaine; Gilles Mithieux; Xavier M Leverve
Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-sensitive manner.
The Journal of biological chemistry 2001;276(30):28126-33.