Shizuo Akira

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Kumagai Yutaro; Akira Shizuo
[Regulation of allergy by innate immune system]
Takeuchi Osamu; Matsushita Kazufumi; Akira Shizuo
[Control of inflammatory responses by a novel RNase, Zc3h12a]
Yanai Hideyuki; Ban Tatsuma; Wang ZhiChao; Choi Myoung Kwon; Kawamura Takeshi; Negishi Hideo; Nakasato Makoto; Lu Yan; Hangai Sho; Koshiba Ryuji; Savitsky David; Ronfani Lorenza; Akira Shizuo; Bianchi Marco E; Honda Kenya; Tamura Tomohiko; Kodama Tatsuhiko; Taniguchi Tadatsugu
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

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All Publications

2009: Kumagai Yutaro; Akira Shizuo
[Regulation of allergy by innate immune system]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(11):2055-61.
2009: Takeuchi Osamu; Matsushita Kazufumi; Akira Shizuo
[Control of inflammatory responses by a novel RNase, Zc3h12a]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(14):1837-41.
2009: Yanai Hideyuki; Ban Tatsuma; Wang ZhiChao; Choi Myoung Kwon; Kawamura Takeshi; Negishi Hideo; Nakasato Makoto; Lu Yan; Hangai Sho; Koshiba Ryuji; Savitsky David; Ronfani Lorenza; Akira Shizuo; Bianchi Marco E; Honda Kenya; Tamura Tomohiko; Kodama Tatsuhiko; Taniguchi Tadatsugu
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
Nature 2009;462(7269):99-103.
2009: Lee Pui Y; Li Yi; Kumagai Yutaro; Xu Yuan; Weinstein Jason S; Kellner Erinn S; Nacionales Dina C; Butfiloski Edward J; van Rooijen Nico; Akira Shizuo; Sobel Eric S; Satoh Minoru; Reeves Westley H
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology 2009;175(5):2023-33.
2009: Fujita Naonobu; Saitoh Tatsuya; Kageyama Shun; Akira Shizuo; Noda Takeshi; Yoshimori Tamotsu
Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts.
The Journal of biological chemistry 2009;284(47):32602-9.
2009: Pejnovic Nada; Vratimos Athanassios; Lee Sang Hee; Popadic Dusan; Takeda Kiyoshi; Akira Shizuo; Chan Woon Ling
Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet.
Molecular immunology 2009;47(1):37-45.
2009: Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Choi Myoung Kwon; Wang ZhiChao; Ban Tatsuma; Yanai Hideyuki; Lu Yan; Koshiba Ryuji; Nakaima Yukana; Hangai Sho; Savitsky David; Nakasato Makoto; Negishi Hideo; Takeuchi Osamu; Honda Kenya; Akira Shizuo; Tamura Tomohiko; Taniguchi Tadatsugu
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17870-5.
2009: Papon Laura; Oteiza Alexandra; Imaizumi Tadaatsu; Kato Hiroki; Brocchi Emiliana; Lawson T Glen; Akira Shizuo; Mechti Nadir
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
Virology 2009;393(2):311-8.
2009: Nairz Manfred; Theurl Igor; Schroll Andrea; Theurl Milan; Fritsche Gernot; Lindner Ewald; Seifert Markus; Crouch Marie-Laure V; Hantke Klaus; Akira Shizuo; Fang Ferric C; Weiss Günter
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.
Blood 2009;114(17):3642-51.
2009: Kumar Himanshu; Kawai Taro; Akira Shizuo
Toll-like receptors and innate immunity.
Biochemical and biophysical research communications 2009;388(4):621-5.
2009: Pichlmair Andreas; Schulz Oliver; Tan Choon-Ping; Rehwinkel Jan; Kato Hiroki; Takeuchi Osamu; Akira Shizuo; Way Michael; Schiavo Giampietro; Reis e Sousa Caetano
Activation of MDA5 requires higher-order RNA structures generated during virus infection.
Journal of virology 2009;83(20):10761-9.
2009: Kawagoe Tatsukata; Takeuchi Osamu; Takabatake Yoshitsugu; Kato Hiroki; Isaka Yoshitaka; Tsujimura Tohru; Akira Shizuo
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
Nature immunology 2009;10(9):965-72.
2009: Yasuda Kei; Richez Christophe; Uccellini Melissa B; Richards Rocco J; Bonegio Ramon G; Akira Shizuo; Monestier Marc; Corley Ronald B; Viglianti Gregory A; Marshak-Rothstein Ann; Rifkin Ian R
Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3109-17.
2009: Kubo Tomohiro; Uchida Yuki; Watanabe Yuko; Abe Masahiro; Nakamura Akira; Ono Masao; Akira Shizuo; Takai Toshiyuki
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
The Journal of experimental medicine 2009;206(9):1971-82.
2009: McWhirter Sarah M; Barbalat Roman; Monroe Kathryn M; Fontana Mary F; Hyodo Mamoru; Joncker Nathalie T; Ishii Ken J; Akira Shizuo; Colonna Marco; Chen Zhijian J; Fitzgerald Katherine A; Hayakawa Yoshihiro; Vance Russell E
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
The Journal of experimental medicine 2009;206(9):1899-911.
2009: Miyake Tohru; Kumagai Yutaro; Kato Hiroki; Guo Zijin; Matsushita Kazufumi; Satoh Takashi; Kawagoe Tatsukata; Kumar Himanshu; Jang Myoung Ho; Kawai Taro; Tani Tohru; Takeuchi Osamu; Akira Shizuo
Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2522-8.
2009: Koyama Shohei; Coban Cevayir; Aoshi Taiki; Horii Toshihiro; Akira Shizuo; Ishii Ken J
Innate immune control of nucleic acid-based vaccine immunogenicity.
Expert review of vaccines 2009;8(8):1099-107.
2009: Imamura Michiko; Tsutsui Hiroko; Yasuda Koubun; Uchiyama Ryosuke; Yumikura-Futatsugi Shizue; Mitani Keiko; Hayashi Shuhei; Akira Shizuo; Taniguchi Shun-Ichiro; Van Rooijen Nico; Tschopp Jurg; Yamamoto Tetsuya; Fujimoto Jiro; Nakanishi Kenji
Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.
Journal of hepatology 2009;51(2):333-41.
2009: Raetzsch Carl F; Brooks Natasha L; Alderman J McKee; Moore Kelli S; Hosick Peter A; Klebanov Simon; Akira Shizuo; Bear James E; Baldwin Albert S; Mackman Nigel; Combs Terry P
Lipopolysaccharide inhibition of glucose production through the Toll-like receptor-4, myeloid differentiation factor 88, and nuclear factor kappa b pathway.
Hepatology (Baltimore, Md.) 2009;50(2):592-600.
2009: Abe Takayuki; Kaname Yuuki; Wen Xiaoyu; Tani Hideki; Moriishi Kohji; Uematsu Satoshi; Takeuchi Osamu; Ishii Ken J; Kawai Taro; Akira Shizuo; Matsuura Yoshiharu
Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
Journal of virology 2009;83(15):7629-40.
2009: Kayama Hisako; Koga Ritsuko; Atarashi Koji; Okuyama Megumi; Kimura Taishi; Mak Tak W; Uematsu Satoshi; Akira Shizuo; Takayanagi Hiroshi; Honda Kenya; Yamamoto Masahiro; Takeda Kiyoshi
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
PLoS pathogens 2009;5(7):e1000514.
2009: Schlee Martin; Roth Andreas; Hornung Veit; Hagmann Cristina Amparo; Wimmenauer Vera; Barchet Winfried; Coch Christoph; Janke Markus; Mihailovic Aleksandra; Wardle Greg; Juranek Stefan; Kato Hiroki; Kawai Taro; Poeck Hendrik; Fitzgerald Katherine A; Takeuchi Osamu; Akira Shizuo; Tuschl Thomas; Latz Eicke; Ludwig Janos; Hartmann Gunther
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Immunity 2009;31(1):25-34.
2009: Shin Ok S; Miller Lloyd S; Modlin Robert L; Akira Shizuo; Uematsu Satoshi; Hu Linden T
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):491-8.
2009: Tirapu Iñigo; Giquel Benoit; Alexopoulou Lena; Uematsu Satoshi; Flavell Richard; Akira Shizuo; Diebold Sandra S
PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation.
International immunology 2009;21(7):871-9.
2009: Miyazato Akiko; Nakamura Kiwamu; Yamamoto Natsuo; Mora-Montes Héctor M; Tanaka Misuzu; Abe Yuzuru; Tanno Daiki; Inden Ken; Gang Xiao; Ishii Keiko; Takeda Kiyoshi; Akira Shizuo; Saijo Shinobu; Iwakura Yoichiro; Adachi Yoshiyuki; Ohno Naohito; Mitsutake Kotaro; Gow Neil A R; Kaku Mitsuo; Kawakami Kazuyoshi
Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans.
Infection and immunity 2009;77(7):3056-64.
2009: Kumagai Yutaro; Saitoh Tatsuya; Akira Shizuo
[Frontiers of research on innate immunity]
Arerugi = [Allergy] 2009;58(6):638-47.
2009: De Trez Carl; Magez Stefan; Akira Shizuo; Ryffel Bernhard; Carlier Yves; Muraille Eric
iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.
PLoS pathogens 2009;5(6):e1000494.
2009: Delaloye Julie; Roger Thierry; Steiner-Tardivel Quynh-Giao; Le Roy Didier; Knaup Reymond Marlies; Akira Shizuo; Petrilli Virginie; Gomez Carmen E; Perdiguero Beatriz; Tschopp Jürg; Pantaleo Giuseppe; Esteban Mariano; Calandra Thierry
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.
PLoS pathogens 2009;5(6):e1000480.
2009: Bates John T; Uematsu Satoshi; Akira Shizuo; Mizel Steven B
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7539-47.
2009: Lu Yong-Chen; Kim Ira; Lye Elizabeth; Shen Fang; Suzuki Nobutaka; Suzuki Shinobu; Gerondakis Steve; Akira Shizuo; Gaffen Sarah L; Yeh Wen-Chen; Ohashi Pamela S
Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):7212-21.
2009: Mancuso Giuseppe; Gambuzza Maria; Midiri Angelina; Biondo Carmelo; Papasergi Salvatore; Akira Shizuo; Teti Giuseppe; Beninati Concetta
Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.
Nature immunology 2009;10(6):587-94.
2009: Janot Laure; Sirard Jean-Claude; Secher Thomas; Noulin Nicolas; Fick Lizette; Akira Shizuo; Uematsu Satoshi; Didierlaurent Arnaud; Hussell Tracy; Ryffel Bernhard; Erard Francois
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
European journal of immunology 2009;39(6):1587-96.
2009: Kenzel Sybille; Santos-Sierra Sandra; Deshmukh Sachin D; Moeller Inga; Ergin Bilge; Fitzgerald Katherine A; Lien Egil; Akira Shizuo; Golenbock Douglas T; Henneke Philipp
Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Infection and immunity 2009;77(6):2474-81.
2009: Kumar Himanshu; Kawai Taro; Akira Shizuo
Pathogen recognition in the innate immune response.
The Biochemical journal 2009;420(1):1-16.
2009: Ueta Mayumi; Uematsu Satoshi; Akira Shizuo; Kinoshita Shigeru
Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis.
The Journal of allergy and clinical immunology 2009;123(5):1187-9.
2009: Matsushita Kazufumi; Takeuchi Osamu; Standley Daron M; Kumagai Yutaro; Kawagoe Tatsukata; Miyake Tohru; Satoh Takashi; Kato Hiroki; Tsujimura Tohru; Nakamura Haruki; Akira Shizuo
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Nature 2009;458(7242):1185-90.
2009: Richter Cornelia; Juan Martina Herrero San; Will Jutta; Brandes Ralf P; Kalinke Ulrich; Akira Shizuo; Pfeilschifter Josef M; Hultqvist Malin; Holmdahl Rikard; Radeke Heinfried H
Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4183-91.
2009: Kumagai Yutaro; Kumar Himanshu; Koyama Shohei; Kawai Taro; Takeuchi Osamu; Akira Shizuo
Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):3960-4.
2009: Li Li; Tanaka Tetsuji; Yukawa Kazunori; Akira Shizuo; Umesaki Naohiko
Irinotecan-induced ovarian follicular apoptosis is attenuated by deleting the kinase domain of death-associated protein kinase.
International journal of oncology 2009;34(4):905-14.
2009: Matsunaga Kohichi; Saitoh Tatsuya; Tabata Keisuke; Omori Hiroko; Satoh Takashi; Kurotori Naoki; Maejima Ikuko; Shirahama-Noda Kanae; Ichimura Tohru; Isobe Toshiaki; Akira Shizuo; Noda Takeshi; Yoshimori Tamotsu
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.
Nature cell biology 2009;11(4):385-96.
2009: Kawai Taro; Akira Shizuo
The roles of TLRs, RLRs and NLRs in pathogen recognition.
International immunology 2009;21(4):317-37.
2009: Puliti Manuela; Uematsu Satoshi; Akira Shizuo; Bistoni Francesco; Tissi Luciana
Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease.
Infection and immunity 2009;77(4):1524-31.
2009: Lichtnekert Julia; Vielhauer Volker; Zecher Daniel; Kulkarni Onkar P; Clauss Sebastian; Segerer Stephan; Hornung Veit; Mayadas Tanya N; Beutler Bruce; Akira Shizuo; Anders Hans-Joachim
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
American journal of physiology. Renal physiology 2009;296(4):F867-74.
2009: Tsukamoto Yumiko; Nagai Yoshinori; Kariyone Ai; Shibata Takuma; Kaisho Tsuneyasu; Akira Shizuo; Miyake Kensuke; Takatsu Kiyoshi
Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.
Molecular immunology 2009;46(7):1278-88.
2009: Amiel Eyal; Alonso Anselmo; Uematsu Satoshi; Akira Shizuo; Poynter Matthew E; Berwin Brent
Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis.
Journal of leukocyte biology 2009;85(4):595-605.
2009: Kumagai Yutaro; Akira Shizuo
[Role of TLR-dependent and independent pathways in autoimmunity]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(3):487-93.
2009: Allard Jenna B; Rinaldi Lisa; Wargo Matthew J; Allen Gilman; Akira Shizuo; Uematsu Satoshi; Poynter Matthew E; Hogan Deborah A; Rincon Mercedes; Whittaker Laurie A
Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products.
European journal of immunology 2009;39(3):776-88.
2009: van Zoelen Marieke A D; Yang Huan; Florquin Sandrine; Meijers Joost C M; Akira Shizuo; Arnold Bernd; Nawroth Peter P; Bierhaus Angelika; Tracey Kevin J; van der Poll Tom
Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo.
Shock (Augusta, Ga.) 2009;31(3):280-4.
2009: Huang Hua; Akira Shizuo; Santos Manuela M
Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?
Hepatology (Baltimore, Md.) 2009;49(3):1012-6.
2009: Kurokawa Kenji; Lee Hanna; Roh Kyung-Baeg; Asanuma Miwako; Kim Young Sook; Nakayama Hiroshi; Shiratsuchi Akiko; Choi Youngnim; Takeuchi Osamu; Kang Hee Jung; Dohmae Naoshi; Nakanishi Yoshinobu; Akira Shizuo; Sekimizu Kazuhisa; Lee Bok Luel
The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2.
The Journal of biological chemistry 2009;284(13):8406-11.
2009: Kim Ju-Hyun; Kim Seon-Ju; Lee Im-Soon; Lee Myung-Shik; Uematsu Satoshi; Akira Shizuo; Oh Kwon Ik
Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2458-66.
2009: Jose Purnima; Avdiushko Margarita G; Akira Shizuo; Kaplan Alan M; Cohen Donald A
Inhibition of interleukin-10 signaling in lung dendritic cells by toll-like receptor 4 ligands.
Experimental lung research 2009;35(1):1-28.
2009: Roger Thierry; Froidevaux Céline; Le Roy Didier; Reymond Marlies Knaup; Chanson Anne-Laure; Mauri Davide; Burns Kim; Riederer Beat Michel; Akira Shizuo; Calandra Thierry
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2348-52.
2009: Yamasaki Sho; Matsumoto Makoto; Takeuchi Osamu; Matsuzawa Tetsuhiro; Ishikawa Eri; Sakuma Machie; Tateno Hiroaki; Uno Jun; Hirabayashi Jun; Mikami Yuzuru; Takeda Kiyoshi; Akira Shizuo; Saito Takashi
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1897-902.
2009: Kobiyama Kouji; Takeshita Fumihiko; Ishii Ken J; Koyama Shohei; Aoshi Taiki; Akira Shizuo; Sakaue-Sawano Asako; Miyawaki Atsushi; Yamanaka Yuko; Hirano Hisashi; Suzuki Koichi; Okuda Kenji
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1593-601.
2009: Sanders Catherine J; Franchi Luigi; Yarovinsky Felix; Uematsu Satoshi; Akira Shizuo; Núñez Gabriel; Gewirtz Andrew T
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.
European journal of immunology 2009;39(2):359-71.
2009: Tokunaga Fuminori; Sakata Shin-ichi; Saeki Yasushi; Satomi Yoshinori; Kirisako Takayoshi; Kamei Kiyoko; Nakagawa Tomoko; Kato Michiko; Murata Shigeo; Yamaoka Shoji; Yamamoto Masahiro; Akira Shizuo; Takao Toshifumi; Tanaka Keiji; Iwai Kazuhiro
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nature cell biology 2009;11(2):123-32.
2009: Tsuchida Tetsuo; Kawai Taro; Akira Shizuo
Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins.
Cell research 2009;19(1):3-4.
2009: Richez Christophe; Yasuda Kei; Watkins Amanda A; Akira Shizuo; Lafyatis Robert; van Seventer Jean M; Rifkin Ian R
TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):820-8.
2009: Filipovich Yana; Lu Shi-Jiang; Akira Shizuo; Hirsch Emmet
The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice.
American journal of obstetrics and gynecology 2009;200(1):93.e1-8.
2009: Takeuchi Osamu; Akira Shizuo
Innate immunity to virus infection.
Immunological reviews 2009;227(1):75-86.
2009: Akira Shizuo
Innate immunity to pathogens: diversity in receptors for microbial recognition.
Immunological reviews 2009;227(1):5-8.
2009: Haga Sanae; Ozaki Michitaka; Inoue Hiroshi; Okamoto Yasuo; Ogawa Wataru; Takeda Kiyoshi; Akira Shizuo; Todo Satoru
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
Hepatology (Baltimore, Md.) 2009;49(1):204-14.
2009: Yamazaki Kohsuke; Gohda Jin; Kanayama Atsuhiro; Miyamoto Yusei; Sakurai Hiroaki; Yamamoto Masahiro; Akira Shizuo; Hayashi Hidetoshi; Su Bing; Inoue Jun-ichiro
Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.
Science signaling 2009;2(93):ra66.
2009: Uematsu Satoshi; Akira Shizuo
Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection.
Journal of gastroenterology 2009;44(8):803-11.
2009: Konno Hiroyasu; Yamamoto Takuya; Yamazaki Kohsuke; Gohda Jin; Akiyama Taishin; Semba Kentaro; Goto Hideo; Kato Atsushi; Yujiri Toshiaki; Imai Takahiko; Kawaguchi Yasushi; Su Bing; Takeuchi Osamu; Akira Shizuo; Tsunetsugu-Yokota Yasuko; Inoue Jun-ichiro
TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.
PloS one 2009;4(5):e5674.
2009: Akira Shizuo
Pathogen recognition by innate immunity and its signaling.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2009;85(4):143-56.
2009: Tsuchiya Masa; Piras Vincent; Choi Sangdun; Akira Shizuo; Tomita Masaru; Giuliani Alessandro; Selvarajoo Kumar
Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages.
PloS one 2009;4(3):e4905.
2009: Kobayashi Takashi; Kim Tae Soo; Jacob Anand; Walsh Matthew C; Kadono Yuho; Fuentes-Pananá Ezequiel; Yoshioka Tomoko; Yoshimura Akihiko; Yamamoto Masahiro; Kaisho Tsuneyasu; Akira Shizuo; Monroe John G; Choi Yongwon
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
PloS one 2009;4(3):e4736.
2008: Saiga Hiroyuki; Nishimura Junichi; Kuwata Hirotaka; Okuyama Megumi; Matsumoto Sohkichi; Sato Shintaro; Matsumoto Makoto; Akira Shizuo; Yoshikai Yasunobu; Honda Kenya; Yamamoto Masahiro; Takeda Kiyoshi
Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8521-7.
2008: Allam Ramanjaneyulu; Pawar Rahul D; Kulkarni Onkar P; Hornung Veit; Hartmann Gunter; Segerer Stephan; Akira Shizuo; Endres Stefan; Anders Hans-Joachim
Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.
European journal of immunology 2008;38(12):3487-98.
2008: Takeuchi Osamu; Akira Shizuo
RIG-I-like antiviral protein in flies.
Nature immunology 2008;9(12):1327-8.
2008: Kawakami Akio; Osaka Mizuko; Aikawa Masanori; Uematsu Satoshi; Akira Shizuo; Libby Peter; Shimokado Kentaro; Sacks Frank M; Yoshida Masayuki
Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation.
Circulation research 2008;103(12):1402-9.
2008: Tominaga Hiroyuki; Maeda Shingo; Hayashi Makoto; Takeda Shu; Akira Shizuo; Komiya Setsuro; Nakamura Takashi; Akiyama Haruhiko; Imamura Takeshi
CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4.
Molecular biology of the cell 2008;19(12):5373-86.
2008: Waibler Zoe; Anzaghe Martina; Konur Abdo; Akira Shizuo; Müller Werner; Kalinke Ulrich
Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.
European journal of immunology 2008;38(11):3127-37.
2008: Saitoh Tatsuya; Fujita Naonobu; Jang Myoung Ho; Uematsu Satoshi; Yang Bo-Gie; Satoh Takashi; Omori Hiroko; Noda Takeshi; Yamamoto Naoki; Komatsu Masaaki; Tanaka Keiji; Kawai Taro; Tsujimura Tohru; Takeuchi Osamu; Yoshimori Tamotsu; Akira Shizuo
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature 2008;456(7219):264-8.
2008: Yamazaki Soh; Matsuo Susumu; Muta Tatsushi; Yamamoto Masahiro; Akira Shizuo; Takeshige Koichiro
Gene-specific requirement of a nuclear protein, IkappaB-zeta, for promoter association of inflammatory transcription regulators.
The Journal of biological chemistry 2008;283(47):32404-11.
2008: Hiratsuka Sachie; Watanabe Akira; Sakurai Yoshiko; Akashi-Takamura Sachiko; Ishibashi Sachie; Miyake Kensuke; Shibuya Masabumi; Akira Shizuo; Aburatani Hiroyuki; Maru Yoshiro
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Nature cell biology 2008;10(11):1349-55.
2008: Karikó Katalin; Muramatsu Hiromi; Welsh Frank A; Ludwig János; Kato Hiroki; Akira Shizuo; Weissman Drew
Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1833-40.
2008: Coban Cevayir; Koyama Shohei; Takeshita Fumihiko; Akira Shizuo; Ishii Ken J
Molecular and cellular mechanisms of DNA vaccines.
Human vaccines 2008;4(6):453-6.
2008: Zhu Qing; Egelston Colt; Vivekanandhan Aravindhan; Uematsu Satoshi; Akira Shizuo; Klinman Dennis M; Belyakov Igor M; Berzofsky Jay A
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16260-5.
2008: Huen Michael S Y; Huang Jun; Yuan Jingsong; Yamamoto Masahiro; Akira Shizuo; Ashley Carolyn; Xiao Wei; Chen Junjie
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
Molecular and cellular biology 2008;28(19):6104-12.
2008: Ishii Ken J; Akira Shizuo
Potential link between the immune system and metabolism of nucleic acids.
Current opinion in immunology 2008;20(5):524-9.
2008: Nakamura Junji; Fujimoto Motoaki; Yasuda Kunihiko; Takeda Kiyoshi; Akira Shizuo; Hatayama Takumi; Takagi Yasushi; Nozaki Kazuhiko; Hosokawa Nobuko; Nagata Kazuhiro
Targeted disruption of Hsp110/105 gene protects against ischemic stress.
Stroke; a journal of cerebral circulation 2008;39(10):2853-9.
2008: Taylor Patricia A; Ehrhardt Michael J; Lees Christopher J; Panoskaltsis-Mortari Angela; Krieg Arthur M; Sharpe Arlene H; Murphy William J; Serody Jonathan S; Hemmi Hiroaki; Akira Shizuo; Levy Robert B; Blazar Bruce R
TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.
Blood 2008;112(8):3508-16.
2008: Koyama Shohei; Ishii Ken J; Coban Cevayir; Akira Shizuo
Innate immune response to viral infection.
Cytokine 2008;43(3):336-41.
2008: Koga Takumi; Endo Hiroko; Miyamoto Yasuhiro; Mukai Mutsuko; Akira Shizuo; Inoue Masahiro
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions.
Cancer letters 2008;268(1):82-8.
2008: Ohbayashi Norihiko; Okada Katsuya; Kawakami Shiho; Togi Sumihito; Sato Noriko; Ikeda Osamu; Kamitani Shinya; Muromoto Ryuta; Sekine Yuichi; Kawai Taro; Akira Shizuo; Matsuda Tadashi
Physical and functional interactions between ZIP kinase and UbcH5.
Biochemical and biophysical research communications 2008;372(4):708-12.
2008: Ueta Mayumi; Hamuro Junji; Ueda Eiichiro; Katoh Norito; Yamamoto Masahiro; Takeda Kiyoshi; Akira Shizuo; Kinoshita Shigeru
Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice.
Investigative ophthalmology & visual science 2008;49(8):3387-94.
2008: Foster Gemma L; Barr Tom A; Grant Andrew J; McKinley Trevelyan J; Bryant Clare E; MacDonald Andrew; Gray David; Yamamoto Masahiro; Akira Shizuo; Maskell Duncan J; Mastroeni Pietro
Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88.
Immunology 2008;124(4):469-79.
2008: Herrmann Julia E; Imura Tetsuya; Song Bingbing; Qi Jingwei; Ao Yan; Nguyen Thu K; Korsak Rose A; Takeda Kiyoshi; Akira Shizuo; Sofroniew Michael V
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(28):7231-43.
2008: Santiago-Raber Marie-Laure; Kikuchi Shuichi; Borel Paula; Uematsu Satoshi; Akira Shizuo; Kotzin Brian L; Izui Shozo
Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1556-62.
2008: Kajino-Sakamoto Rie; Inagaki Maiko; Lippert Elisabeth; Akira Shizuo; Robine Sylvie; Matsumoto Kunihiro; Jobin Christian; Ninomiya-Tsuji Jun
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1143-52.
2008: Kato Hiroki; Takeuchi Osamu; Mikamo-Satoh Eriko; Hirai Reiko; Kawai Tomoji; Matsushita Kazufumi; Hiiragi Akane; Dermody Terence S; Fujita Takashi; Akira Shizuo
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
The Journal of experimental medicine 2008;205(7):1601-10.
2008: Tang Minghui; Wei Xudong; Guo Yinshi; Breslin Peter; Zhang Shubin; Zhang Shanshan; Wei Wei; Xia Zhenbiao; Diaz Manuel; Akira Shizuo; Zhang Jiwang
TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.
The Journal of experimental medicine 2008;205(7):1611-9.
2008: Uematsu Satoshi; Fujimoto Kosuke; Jang Myoung Ho; Yang Bo-Gie; Jung Yun-Jae; Nishiyama Mika; Sato Shintaro; Tsujimura Tohru; Yamamoto Masafumi; Yokota Yoshifumi; Kiyono Hiroshi; Miyasaka Masayuki; Ishii Ken J; Akira Shizuo
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nature immunology 2008;9(7):769-76.
2008: Kobayashi Toshihiko; Takahashi Koichiro; Nagai Yoshinori; Shibata Takuma; Otani Masako; Izui Shozo; Akira Shizuo; Gotoh Yoshiyuki; Kiyono Hiroshi; Miyake Kensuke
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
International immunology 2008;20(7):881-91.
2008: Gratz Nina; Siller Maria; Schaljo Barbara; Pirzada Zaid A; Gattermeier Irene; Vojtek Ivo; Kirschning Carsten J; Wagner Hermann; Akira Shizuo; Charpentier Emmanuelle; Kovarik Pavel
Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.
The Journal of biological chemistry 2008;283(29):19879-87.
2008: Gong Lijie; Yao Fayi; Hockman Kristin; Heng Henry H; Morton Gregory J; Takeda Kiyoshi; Akira Shizuo; Low Malcolm J; Rubinstein Marcelo; MacKenzie Robert G
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.
Endocrinology 2008;149(7):3346-54.
2008: Ishii Ken J; Koyama Shohei; Nakagawa Atsushi; Coban Cevayir; Akira Shizuo
Host innate immune receptors and beyond: making sense of microbial infections.
Cell host & microbe 2008;3(6):352-63.
2008: Kawagoe Tatsukata; Sato Shintaro; Matsushita Kazufumi; Kato Hiroki; Matsui Kosuke; Kumagai Yutaro; Saitoh Tatsuya; Kawai Taro; Takeuchi Osamu; Akira Shizuo
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Nature immunology 2008;9(6):684-91.
2008: Shin Ok S; Isberg Ralph R; Akira Shizuo; Uematsu Satoshi; Behera Aruna K; Hu Linden T
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.
Infection and immunity 2008;76(6):2341-51.
2008: Zucchini Nicolas; Bessou Gilles; Traub Stephanie; Robbins Scott H; Uematsu Satoshi; Akira Shizuo; Alexopoulou Lena; Dalod Marc
Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5799-803.
2008: Samuelsson Christofer; Hausmann Jürgen; Lauterbach Henning; Schmidt Michaela; Akira Shizuo; Wagner Hermann; Chaplin Paul; Suter Mark; O'Keeffe Meredith; Hochrein Hubertus
Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection.
The Journal of clinical investigation 2008;118(5):1776-84.
2008: Hirata Noriyuki; Yanagawa Yoshiki; Ebihara Takashi; Seya Tsukasa; Uematsu Satoshi; Akira Shizuo; Hayashi Fumie; Iwabuchi Kazuya; Onoé Kazunori
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Molecular immunology 2008;45(10):2734-42.
2008: Zhang Binzhi; Ramesh Ganesan; Uematsu Satoshi; Akira Shizuo; Reeves W Brian
TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity.
Journal of the American Society of Nephrology : JASN 2008;19(5):923-32.
2008: Kumagai Yutaro; Takeuchi Osamu; Akira Shizuo
Pathogen recognition by innate receptors.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2008;14(2):86-92.
2008: Imai Yumiko; Kuba Keiji; Neely G Greg; Yaghubian-Malhami Rubina; Perkmann Thomas; van Loo Geert; Ermolaeva Maria; Veldhuizen Ruud; Leung Y H Connie; Wang Hongliang; Liu Haolin; Sun Yang; Pasparakis Manolis; Kopf Manfred; Mech Christin; Bavari Sina; Peiris J S Malik; Slutsky Arthur S; Akira Shizuo; Hultqvist Malin; Holmdahl Rikard; Nicholls John; Jiang Chengyu; Binder Christoph J; Penninger Josef M
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Cell 2008;133(2):235-49.
2008: Tomita Takayuki; Kanai Takanori; Fujii Toshimitsu; Nemoto Yasuhiro; Okamoto Ryuichi; Tsuchiya Kiichiro; Totsuka Teruji; Sakamoto Naoya; Akira Shizuo; Watanabe Mamoru
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5291-9.
2008: Savarese Emina; Steinberg Christian; Pawar Rahul D; Reindl Wolfgang; Akira Shizuo; Anders Hans-Joachim; Krug Anne
Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis.
Arthritis and rheumatism 2008;58(4):1107-15.
2008: Kagan Jonathan C; Su Tian; Horng Tiffany; Chow Amy; Akira Shizuo; Medzhitov Ruslan
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.
Nature immunology 2008;9(4):361-8.
2008: Kumagai Yutaro; Takeuchi Osamu; Akira Shizuo
TLR9 as a key receptor for the recognition of DNA.
Advanced drug delivery reviews 2008;60(7):795-804.
2008: Nakamura Kiwamu; Miyazato Akiko; Xiao Gang; Hatta Masumitsu; Inden Ken; Aoyagi Tetsuji; Shiratori Kohei; Takeda Kiyoshi; Akira Shizuo; Saijo Shinobu; Iwakura Yoichiro; Adachi Yoshiyuki; Ohno Naohito; Suzuki Kazuo; Fujita Jiro; Kaku Mitsuo; Kawakami Kazuyoshi
Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4067-74.
2008: Nishimura Junichi; Saiga Hiroyuki; Sato Shintaro; Okuyama Megumi; Kayama Hisako; Kuwata Hirotaka; Matsumoto Sohkichi; Nishida Toshirou; Sawa Yoshiki; Akira Shizuo; Yoshikai Yasunobu; Yamamoto Masahiro; Takeda Kiyoshi
Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):4032-9.
2008: Hölscher Christoph; Reiling Norbert; Schaible Ulrich E; Hölscher Alexandra; Bathmann Clara; Korbel Daniel; Lenz Insa; Sonntag Tanja; Kröger Svenja; Akira Shizuo; Mossmann Horst; Kirschning Carsten J; Wagner Hermann; Freudenberg Marina; Ehlers Stefan
Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.
European journal of immunology 2008;38(3):680-94.
2008: Vijay-Kumar Matam; Aitken Jesse D; Kumar Amrita; Neish Andrew S; Uematsu Satoshi; Akira Shizuo; Gewirtz Andrew T
Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease.
Infection and immunity 2008;76(3):1276-81.
2008: Escors David; Lopes Luciene; Lin Rongtuan; Hiscott John; Akira Shizuo; Davis Roger J; Collins Mary K
Targeting dendritic cell signaling to regulate the response to immunization.
Blood 2008;111(6):3050-61.
2008: Akagi Tadayuki; Saitoh Takayuki; O'Kelly James; Akira Shizuo; Gombart Adrian F; Koeffler H Phillip
Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
Blood 2008;111(6):2999-3004.
2008: Yang Chul-Su; Shin Dong-Min; Lee Hye-Mi; Son Ji Woong; Lee Sung Joong; Akira Shizuo; Gougerot-Pocidalo Marie-Anne; El-Benna Jamel; Ichijo Hidenori; Jo Eun-Kyeong
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.
Cellular microbiology 2008;10(3):741-54.
2008: Newman Jennifer P A; Banerjee Birendranath; Fang Wanru; Poonepalli Anuradha; Balakrishnan Lakshmidevi; Low Grace Kah Mun; Bhattacharjee Rabindra N; Akira Shizuo; Jayapal Manikandan; Melendez Alirio J; Baskar Rajamanickam; Lee Han-Woong; Hande M Prakash
Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells.
Journal of cellular physiology 2008;214(3):796-809.
2008: Uematsu Satoshi; Akira Shizuo
[Innate immunity and tuberculosis]
Kekkaku : [Tuberculosis] 2008;83(2):101-9.
2008: Takeuchi Osamu; Akira Shizuo
MDA5/RIG-I and virus recognition.
Current opinion in immunology 2008;20(1):17-22.
2008: Ishii Ken J; Kawagoe Tatsukata; Koyama Shohei; Matsui Kosuke; Kumar Himanshu; Kawai Taro; Uematsu Satoshi; Takeuchi Osamu; Takeshita Fumihiko; Coban Cevayir; Akira Shizuo
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Nature 2008;451(7179):725-9.
2008: Hisaeda Hajime; Tetsutani Kohhei; Imai Takashi; Moriya Chikako; Tu Liping; Hamano Shinjiro; Duan Xuefeng; Chou Bin; Ishida Hidekazu; Aramaki Akiko; Shen Jianying; Ishii Ken J; Coban Cevayir; Akira Shizuo; Takeda Kiyoshi; Yasutomo Koji; Torii Motomi; Himeno Kunisuke
Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2496-503.
2008: Nakano Yoshiteru; Kuroda Etsushi; Kito Tomohiro; Uematsu Satoshi; Akira Shizuo; Yokota Akira; Nishizawa Shigeru; Yamashita Uki
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.
Journal of neurosurgery 2008;108(2):311-9.
2008: Chang Sun-Young; Cha Hye-Ran; Uematsu Satoshi; Akira Shizuo; Igarashi Osamu; Kiyono Hiroshi; Kweon Mi-Na
Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1609-18.
2008: Noor Shahid; Goldfine Howard; Tucker Dawn E; Suram Saritha; Lenz Laurel L; Akira Shizuo; Uematsu Satoshi; Girotti Milena; Bonventre Joseph V; Breuel Kevin; Williams David L; Leslie Christina C
Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.
The Journal of biological chemistry 2008;283(8):4744-55.
2008: Wilson Nicholas S; Young Louise J; Kupresanin Fiona; Naik Shalin H; Vremec David; Heath William R; Akira Shizuo; Shortman Ken; Boyle Jeff; Maraskovsky Eugene; Belz Gabrielle T; Villadangos José A
Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.
Immunology and cell biology 2008;86(2):200-5.
2008: Bhattacharjee Rabindra N; Park Kwon-sam; Chen Xiuhao; Iida Tetsuya; Honda Takeshi; Takeuchi Osamu; Akira Shizuo
Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling.
Journal of microbiology and biotechnology 2008;18(1):171-5.
2008: Kumar Himanshu; Koyama Shohei; Ishii Ken J; Kawai Taro; Akira Shizuo
Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):683-7.
2008: Swann Jeremy B; Vesely Matthew D; Silva Anabel; Sharkey Janelle; Akira Shizuo; Schreiber Robert D; Smyth Mark J
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):652-6.
2008: Stenzel Werner; Soltek Sabine; Sanchez-Ruiz Monica; Akira Shizuo; Miletic Hrvoje; Schlüter Dirk; Deckert Martina
Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.
The American journal of pathology 2008;172(1):132-45.
2008: Yamakawa Kiyofumi; Kamekura Satoru; Kawamura Naohiro; Saegusa Masatomo; Kamei Daisuke; Murakami Makoto; Kudo Ichiro; Uematsu Satoshi; Akira Shizuo; Chung Ung-il; Nakamura Kozo; Kawaguchi Hiroshi
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis and rheumatism 2008;58(1):172-83.
2008: Goto Akira; Matsushita Kazufumi; Gesellchen Viola; El Chamy Laure; Kuttenkeuler David; Takeuchi Osamu; Hoffmann Jules A; Akira Shizuo; Boutros Michael; Reichhart Jean-Marc
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Nature immunology 2008;9(1):97-104.
2008: Abdollahi-Roodsaz Shahla; Joosten Leo A B; Koenders Marije I; Devesa Isabel; Roelofs Mieke F; Radstake Timothy R D J; Heuvelmans-Jacobs Marleen; Akira Shizuo; Nicklin Martin J H; Ribeiro-Dias Fátima; van den Berg Wim B
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.
The Journal of clinical investigation 2008;118(1):205-16.
2008: Sugiyama Takahiro; Hoshino Katsuaki; Saito Masuyoshi; Yano Takahiro; Sasaki Izumi; Yamazaki Chihiro; Akira Shizuo; Kaisho Tsuneyasu
Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.
International immunology 2008;20(1):1-9.
2008: Loo Yueh-Ming; Fornek Jamie; Crochet Nanette; Bajwa Gagan; Perwitasari Olivia; Martinez-Sobrido Luis; Akira Shizuo; Gill Michelle A; García-Sastre Adolfo; Katze Michael G; Gale Michael
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Journal of virology 2008;82(1):335-45.
2008: Jung Andreas; Kato Hiroki; Kumagai Yutaro; Kumar Himanshu; Kawai Taro; Takeuchi Osamu; Akira Shizuo
Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
Journal of virology 2008;82(1):196-206.
2008: Selvarajoo Kumar; Takada Yasunari; Gohda Jin; Helmy Mohamed; Akira Shizuo; Tomita Masaru; Tsuchiya Masa; Inoue Jun-Ichiro; Matsuo Koichi
Signaling flux redistribution at toll-like receptor pathway junctions.
PloS one 2008;3(10):e3430.
2008: Uematsu Satoshi; Akira Shizuo
Toll-Like receptors (TLRs) and their ligands.
Handbook of experimental pharmacology 2008;(183):1-20.
2007: Vijay-Kumar Matam; Sanders Catherine J; Taylor Rebekah T; Kumar Amrita; Aitken Jesse D; Sitaraman Shanthi V; Neish Andrew S; Uematsu Satoshi; Akira Shizuo; Williams Ifor R; Gewirtz Andrew T
Deletion of TLR5 results in spontaneous colitis in mice.
The Journal of clinical investigation 2007;117(12):3909-21.
2007: Gasse Pamela; Mary Caroline; Guenon Isabelle; Noulin Nicolas; Charron Sabine; Schnyder-Candrian Silvia; Schnyder Bruno; Akira Shizuo; Quesniaux Valérie F J; Lagente Vincent; Ryffel Bernhard; Couillin Isabelle
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
The Journal of clinical investigation 2007;117(12):3786-99.
2007: Takeuchi Osamu; Akira Shizuo
Recognition of viruses by innate immunity.
Immunological reviews 2007;220():214-24.
2007: Shembade Noula; Harhaj Nicole S; Yamamoto Masahiro; Akira Shizuo; Harhaj Edward W
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Journal of virology 2007;81(24):13735-42.
2007: Ho Lien H; Ohno Tatsukuni; Oboki Keisuke; Kajiwara Naoki; Suto Hajime; Iikura Motoyasu; Okayama Yoshimichi; Akira Shizuo; Saito Hirohisa; Galli Stephen J; Nakae Susumu
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
Journal of leukocyte biology 2007;82(6):1481-90.
2007: Kawai Taro; Akira Shizuo
Signaling to NF-kappaB by Toll-like receptors.
Trends in molecular medicine 2007;13(11):460-9.
2007: Hawn Thomas R; Berrington William R; Smith Ian A; Uematsu Satoshi; Akira Shizuo; Aderem Alan; Smith Kelly D; Skerrett Shawn J
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6981-7.
2007: Waibler Zoe; Anzaghe Martina; Ludwig Holger; Akira Shizuo; Weiss Siegfried; Sutter Gerd; Kalinke Ulrich
Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses.
Journal of virology 2007;81(22):12102-10.
2007: Zhande Rachel; Dauphinee Shauna M; Thomas James A; Yamamoto Masahiro; Akira Shizuo; Karsan Aly
FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction.
Molecular and cellular biology 2007;27(21):7394-404.
2007: Sakamori Ryotaro; Takehara Tetsuo; Ohnishi Chihiro; Tatsumi Tomohide; Ohkawa Kazuyoshi; Takeda Kiyoshi; Akira Shizuo; Hayashi Norio
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.
Hepatology (Baltimore, Md.) 2007;46(5):1564-73.
2007: Uematsu Satoshi; Kaisho Tsuneyasu; Tanaka Takashi; Matsumoto Makoto; Yamakami Megumi; Omori Hiroko; Yamamoto Masahiro; Yoshimori Tamotsu; Akira Shizuo
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5378-86.
2007: Beutler Bruce; Eidenschenk Celine; Crozat Karine; Imler Jean-Luc; Takeuchi Osamu; Hoffmann Jules A; Akira Shizuo
Genetic analysis of resistance to viral infection.
Nature reviews. Immunology 2007;7(10):753-66.
2007: Koyama Shohei; Ishii Ken J; Kumar Himanshu; Tanimoto Takeshi; Coban Cevayir; Uematsu Satoshi; Kawai Taro; Akira Shizuo
Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4711-20.
2007: Kang Young Jun; Kusler Brenda; Otsuka Motoyuki; Hughes Michael; Suzuki Nobutaka; Suzuki Shinobu; Yeh Wen-Chen; Akira Shizuo; Han Jiahuai; Jones Patricia P
Calcineurin negatively regulates TLR-mediated activation pathways.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4598-607.
2007: Cook Pamela; Tötemeyer Sabine; Stevenson Catherine; Fitzgerald Katherine A; Yamamoto Masahiro; Akira Shizuo; Maskell Duncan J; Bryant Clare E
Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Immunology 2007;122(2):222-9.
2007: Biswas Subhra K; Bist Pradeep; Dhillon Manprit Kaur; Kajiji Tasneem; Del Fresno Carlos; Yamamoto Masahiro; Lopez-Collazo Eduardo; Akira Shizuo; Tergaonkar Vinay
Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):4083-92.
2007: Bhan Urvashi; Lukacs Nicholas W; Osterholzer John J; Newstead Michael W; Zeng Xianying; Moore Thomas A; McMillan Tracy R; Krieg Arthur M; Akira Shizuo; Standiford Theodore J
TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3937-46.
2007: Bevelander Mieke; Mayette Jana; Whittaker Laurie A; Paveglio Sara A; Jones Christine C; Robbins Justin; Hemenway David; Akira Shizuo; Uematsu Satoshi; Poynter Matthew E
Nitrogen dioxide promotes allergic sensitization to inhaled antigen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3680-8.
2007: Yamamoto Masahiro; Uematsu Satoshi; Okamoto Toru; Matsuura Yoshiharu; Sato Shintaro; Kumar Himanshu; Satoh Takashi; Saitoh Tatsuya; Takeda Kiyoshi; Ishii Ken J; Takeuchi Osamu; Kawai Taro; Akira Shizuo
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
The Journal of experimental medicine 2007;204(9):2233-9.
2007: Lang Karl S; Navarini Alexander A; Recher Mike; Lang Philipp A; Heikenwalder Mathias; Stecher Barbara; Bergthaler Andreas; Odermatt Bernhard; Akira Shizuo; Honda Kenya; Hengartner Hans; Zinkernagel Rolf M
MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus.
European journal of immunology 2007;37(9):2434-40.
2007: Abe Takayuki; Kaname Yuuki; Hamamoto Itsuki; Tsuda Yoshimi; Wen Xiaoyu; Taguwa Shuhei; Moriishi Kohji; Takeuchi Osamu; Kawai Taro; Kanto Tatsuya; Hayashi Norio; Akira Shizuo; Matsuura Yoshiharu
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.
Journal of virology 2007;81(17):8953-66.
2007: Uematsu Satoshi; Akira Shizuo
[Toll-like receptor and innate immunity]
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(8):769-76.
2007: Kumagai Yutaro; Takeuchi Osamu; Kato Hiroki; Kumar Himanshu; Matsui Kosuke; Morii Eiichi; Aozasa Katsuyuki; Kawai Taro; Akira Shizuo
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Immunity 2007;27(2):240-52.
2007: Tezuka Hiroyuki; Abe Yukiko; Iwata Makoto; Takeuchi Hajime; Ishikawa Hiromichi; Matsushita Masayuki; Shiohara Tetsuo; Akira Shizuo; Ohteki Toshiaki
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.
Nature 2007;448(7156):929-33.
2007: Jounai Nao; Takeshita Fumihiko; Kobiyama Kouji; Sawano Asako; Miyawaki Atsushi; Xin Ke-Qin; Ishii Ken J; Kawai Taro; Akira Shizuo; Suzuki Koichi; Okuda Kenji
The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14050-5.
2007: Kim Hun Sik; Han Myoung Sook; Chung Kun Wook; Kim Sunshin; Kim Eunshil; Kim Myoung Joo; Jang Eunkyeong; Lee Hyun Ah; Youn Jeehee; Akira Shizuo; Lee Myung-Shik
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes.
Immunity 2007;27(2):321-33.
2007: Li Jiali; Song Wenru; Czerwinski Debra K; Varghese Bindu; Uematsu Satoshi; Akira Shizuo; Krieg Arthur M; Levy Ronald
Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2493-500.
2007: Han Jin-Hwan; Akira Shizuo; Calame Kathryn; Beutler Bruce; Selsing Erik; Imanishi-Kari Thereza
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.
Immunity 2007;27(1):64-75.
2007: Saha Sukumar; Takeshita Fumihiko; Matsuda Tomoko; Jounai Nao; Kobiyama Kouji; Matsumoto Tetsuya; Sasaki Shin; Yoshida Atsushi; Xin Ke-Qin; Klinman Dennis M; Uematsu Satoshi; Ishii Ken J; Akira Shizuo; Okuda Kenji
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1147-54.
2007: Ikeda Fumiyo; Hecker Christina Maria; Rozenknop Alexis; Nordmeier Rolf Dietrich; Rogov Vladimir; Hofmann Kay; Akira Shizuo; Dötsch Volker; Dikic Ivan
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
The EMBO journal 2007;26(14):3451-62.
2007: Chen Chun-Jen; Kono Hajime; Golenbock Douglas; Reed George; Akira Shizuo; Rock Kenneth L
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
Nature medicine 2007;13(7):851-6.
2007: Roberts Zachary J; Goutagny Nadege; Perera Pin-Yu; Kato Hiroki; Kumar Himanshu; Kawai Taro; Akira Shizuo; Savan Ram; van Echo David; Fitzgerald Katherine A; Young Howard A; Ching Lai-Ming; Vogel Stefanie N
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
The Journal of experimental medicine 2007;204(7):1559-69.
2007: Shimada Naohiko; Coban Cevayir; Takeda Yoichi; Mizu Masami; Minari Jusaku; Anada Takahisa; Torii Yuichi; Shinkai Seiji; Akira Shizuo; Ishii Ken J; Sakurai Kazuo
A polysaccharide carrier to effectively deliver native phosphodiester CpG DNA to antigen-presenting cells.
Bioconjugate chemistry 2007;18(4):1280-6.
2007: Ramesh Ganesan; Zhang Binzhi; Uematsu Satoshi; Akira Shizuo; Reeves W Brian
Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.
American journal of physiology. Renal physiology 2007;293(1):F325-32.
2007: Ishii Ken J; Akira Shizuo
Toll or toll-free adjuvant path toward the optimal vaccine development.
Journal of clinical immunology 2007;27(4):363-71.
2007: Tao Kayoko; Fujii Mutsuko; Tsukumo Shin-ichi; Maekawa Yoichi; Kishihara Kenji; Kimoto Yasutaka; Horiuchi Takahiko; Hisaeda Hajime; Akira Shizuo; Kagami Shoji; Yasutomo Koji
Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.
Annals of the rheumatic diseases 2007;66(7):905-9.
2007: Takeuchi Osamu; Akira Shizuo
[Pathogen recognition by innate immunity]
Arerugi = [Allergy] 2007;56(6):558-62.
2007: Puthalakath Hamsa; O'Reilly Lorraine A; Gunn Priscilla; Lee Lily; Kelly Priscilla N; Huntington Nicholas D; Hughes Peter D; Michalak Ewa M; McKimm-Breschkin Jennifer; Motoyama Noburo; Gotoh Tomomi; Akira Shizuo; Bouillet Philippe; Strasser Andreas
ER stress triggers apoptosis by activating BH3-only protein Bim.
Cell 2007;129(7):1337-49.
2007: Kawai Taro; Akira Shizuo
SnapShot: Pattern-recognition receptors.
Cell 2007;129(5):1024.
2007: Bobacz K; Sunk I G; Hofstaetter J G; Amoyo L; Toma C D; Akira S; Weichhart T; Saemann M; Smolen J S
Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7.
Arthritis and rheumatism 2007;56(6):1880-93.
2007: Yasuda Kei; Richez Christophe; Maciaszek Joseph W; Agrawal Neerja; Akira Shizuo; Marshak-Rothstein Ann; Rifkin Ian R
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6876-85.
2007: Imanishi Takayuki; Hara Hiromitsu; Suzuki Shinobu; Suzuki Nobutaka; Akira Shizuo; Saito Takashi
Cutting edge: TLR2 directly triggers Th1 effector functions.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6715-9.
2007: Shim Doo-Hee; Chang Sun-Young; Park Sung-Moo; Jang Hyun; Carbis Rodney; Czerkinsky Cecil; Uematsu Satoshi; Akira Shizuo; Kweon Mi-Na
Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a.
Vaccine 2007;25(25):4828-36.
2007: Coban Cevayir; Ishii Ken J; Horii Toshihiro; Akira Shizuo
Manipulation of host innate immune responses by the malaria parasite.
Trends in microbiology 2007;15(6):271-8.
2007: Takeda Kiyoshi; Akira Shizuo
Toll-like receptors.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2007;Chapter 14():Unit 14.12.
2007: Kawagoe Tatsukata; Sato Shintaro; Jung Andreas; Yamamoto Masahiro; Matsui Kosuke; Kato Hiroki; Uematsu Satoshi; Takeuchi Osamu; Akira Shizuo
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
The Journal of experimental medicine 2007;204(5):1013-24.
2007: Uematsu Satoshi; Akira Shizuo
Toll-like receptors and Type I interferons.
The Journal of biological chemistry 2007;282(21):15319-23.
2007: Kim Donghoon; Kim Myung Ah; Cho Ik-Hyun; Kim Mi Sun; Lee Soojin; Jo Eun-Kyeong; Choi Se-Young; Park Kyungpyo; Kim Joong Soo; Akira Shizuo; Na Heung Sik; Oh Seog Bae; Lee Sung Joong
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity.
The Journal of biological chemistry 2007;282(20):14975-83.
2007: Obonyo Marygorret; Sabet Mojgan; Cole Sheri P; Ebmeyer Joerg; Uematsu Satoshi; Akira Shizuo; Guiney Donald G
Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.
Infection and immunity 2007;75(5):2408-14.
2007: Dessing Mark C; van der Sluijs Koenraad F; Florquin Sandrine; Akira Shizuo; van der Poll Tom
Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia.
American journal of respiratory cell and molecular biology 2007;36(5):609-14.
2007: Andersen-Nissen Erica; Hawn Thomas R; Smith Kelly D; Nachman Alex; Lampano Aaron E; Uematsu Satoshi; Akira Shizuo; Aderem Alan
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4717-20.
2007: Gack Michaela U; Shin Young C; Joo Chul-Hyun; Urano Tomohiko; Liang Chengyu; Sun Lijun; Takeuchi Osamu; Akira Shizuo; Chen Zhijian; Inoue Satoshi; Jung Jae U
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Nature 2007;446(7138):916-920.
2007: Takeuchi Osamu; Akira Shizuo
Signaling pathways activated by microorganisms.
Current opinion in cell biology 2007;19(2):185-91.
2007: Qiao Hong; Sonoda Koh-Hei; Ikeda Yasuhiro; Yoshimura Takeru; Hijioka Kuniaki; Jo Young-Joon; Sassa Yukio; Tsutsumi-Miyahara Chikako; Hata Yasuaki; Akira Shizuo; Ishibashi Tatsuro
Interleukin-18 regulates pathological intraocular neovascularization.
Journal of leukocyte biology 2007;81(4):1012-21.
2007: Alugupalli Kishore R; Akira Shizuo; Lien Egil; Leong John M
MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3740-9.
2007: Power Melanie R; Li Bo; Yamamoto Masahiro; Akira Shizuo; Lin Tong-Jun
A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3170-6.
2007: Jeyaseelan Samithamby; Young Scott K; Fessler Michael B; Liu Yuhong; Malcolm Kenneth C; Yamamoto Masahiro; Akira Shizuo; Worthen G Scott
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3153-60.
2007: Hamm Svetlana; Heit Antje; Koffler Martina; Huster Katharina M; Akira Shizuo; Busch Dirk H; Wagner Herrmann; Bauer Stefan
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.
International immunology 2007;19(3):297-304.
2007: Sawaki Junko; Tsutsui Hiroko; Hayashi Nobuki; Yasuda Koubun; Akira Shizuo; Tanizawa Takakuni; Nakanishi Kenji
Type 1 cytokine/chemokine production by mouse NK cells following activation of their TLR/MyD88-mediated pathways.
International immunology 2007;19(3):311-20.
2007: Onoguchi Kazuhide; Yoneyama Mitsutoshi; Takemura Azumi; Akira Shizuo; Taniguchi Tadatsugu; Namiki Hideo; Fujita Takashi
Viral infections activate types I and III interferon genes through a common mechanism.
The Journal of biological chemistry 2007;282(10):7576-81.
2007: Yao Jianhong; Kim Tae Whan; Qin Jinzhong; Jiang Zhengfan; Qian Youcun; Xiao Hui; Lu Yi; Qian Wen; Gulen Muhammet Fatih; Sizemore Nywana; DiDonato Joseph; Sato Shintaro; Akira Shizuo; Su Bing; Li Xiaoxia
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification.
The Journal of biological chemistry 2007;282(9):6075-89.
2007: Albiger Barbara; Dahlberg Sofia; Sandgren Andreas; Wartha Florian; Beiter Katharina; Katsuragi Hiroaki; Akira Shizuo; Normark Staffan; Henriques-Normark Birgitta
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.
Cellular microbiology 2007;9(3):633-44.
2007: Miggin Sinead M; Pålsson-McDermott Eva; Dunne Aisling; Jefferies Caroline; Pinteaux Emmanuel; Banahan Kathy; Murphy Caroline; Moynagh Paul; Yamamoto Masahiro; Akira Shizuo; Rothwell Nancy; Golenbock Douglas; Fitzgerald Katherine A; O'Neill Luke A J
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: Heer Alex K; Shamshiev Abdijapar; Donda Alena; Uematsu Satoshi; Akira Shizuo; Kopf Manfred; Marsland Benjamin J
TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2182-91.
2007: Kawai Taro; Akira Shizuo
TLR signaling.
Seminars in immunology 2007;19(1):24-32.
2007: Kawai Taro; Akira Shizuo
Antiviral signaling through pattern recognition receptors.
Journal of biochemistry 2007;141(2):137-45.
2007: Cervantes-Barragan Luisa; Züst Roland; Weber Friedemann; Spiegel Martin; Lang Karl S; Akira Shizuo; Thiel Volker; Ludewig Burkhard
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Blood 2007;109(3):1131-7.
2007: Yang Chul-Su; Lee Ji-Sook; Song Chang-Hwa; Hur Gang Min; Lee Sung Joong; Tanaka Sakae; Akira Shizuo; Paik Tae-Hyun; Jo Eun-Kyeong
Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.
Cellular microbiology 2007;9(2):382-96.
2007: Saito Takeshi; Hirai Reiko; Loo Yueh-Ming; Owen David; Johnson Cynthia L; Sinha Sangita C; Akira Shizuo; Fujita Takashi; Gale Michael
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):582-7.
2007: Saijo Shinobu; Fujikado Noriyuki; Furuta Takahisa; Chung Soo-hyun; Kotaki Hayato; Seki Keisuke; Sudo Katsuko; Akira Shizuo; Adachi Yoshiyuki; Ohno Naohito; Kinjo Takeshi; Nakamura Kiwamu; Kawakami Kazuyoshi; Iwakura Yoichiro
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.
Nature immunology 2007;8(1):39-46.
2007: Coban Cevayir; Ishii Ken J; Uematsu Satoshi; Arisue Nobuko; Sato Shintaro; Yamamoto Masahiro; Kawai Taro; Takeuchi Osamu; Hisaeda Hajime; Horii Toshihiro; Akira Shizuo
Pathological role of Toll-like receptor signaling in cerebral malaria.
International immunology 2007;19(1):67-79.
2007: Sakata Yasushi; Dong Jian-Wen; Vallejo Jesus G; Huang Chien-Hua; Baker J Scott; Tracey Kevin J; Tacheuchi Osamu; Akira Shizuo; Mann Douglas L
Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H503-9.
2006: Samarasinghe Ranmal; Tailor Prafullakumar; Tamura Tomohiko; Kaisho Tsuneyasu; Akira Shizuo; Ozato Keiko
Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2006;26(12):893-900.
2006: Harada Michishige; Magara-Koyanagi Kumiko; Watarai Hiroshi; Nagata Yuko; Ishii Yasuyuki; Kojo Satoshi; Horiguchi Shigetoshi; Okamoto Yoshitaka; Nakayama Toshinori; Suzuki Nobutaka; Yeh Wen-Chen; Akira Shizuo; Kitamura Hiroshi; Ohara Osamu; Seino Ken-ichiro; Taniguchi Masaru
IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.
The Journal of experimental medicine 2006;203(13):2929-37.
2006: Choo Min-Kyung; Kawasaki Noritaka; Singhirunnusorn Pattama; Koizumi Keiichi; Sato Shintaro; Akira Shizuo; Saiki Ikuo; Sakurai Hiroaki
Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
Molecular cancer therapeutics 2006;5(12):2970-6.
2006: Boonstra André; Rajsbaum Ricardo; Holman Mary; Marques Rute; Asselin-Paturel Carine; Pereira João Pedro; Bates Elizabeth E M; Akira Shizuo; Vieira Paulo; Liu Yong-Jun; Trinchieri Giorgio; O'Garra Anne
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7551-8.
2006: Yamamoto Masahiro; Sato Shintaro; Saitoh Tatsuya; Sakurai Hiroaki; Uematsu Satoshi; Kawai Taro; Ishii Ken J; Takeuchi Osamu; Akira Shizuo
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7520-4.
2006: Diebold Sandra S; Massacrier Catherine; Akira Shizuo; Paturel Carine; Morel Yannis; Reis e Sousa Caetano
Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides.
European journal of immunology 2006;36(12):3256-67.
2006: Furuta Takahisa; Kikuchi Takane; Akira Shizuo; Watanabe Naohiro; Yoshikawa Yasuhiro
Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
International immunology 2006;18(12):1655-62.
2006: Bolz Devin D; Sundsbak Rhianna S; Ma Ying; Akira Shizuo; Weis John H; Schwan Tom G; Weis Janis J
Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp.
Infection and immunity 2006;74(12):6750-60.
2006: Bhattacharjee Rabindra N; Park Kwon-Sam; Kumagai Yutaro; Okada Kazuhisa; Yamamoto Masahiro; Uematsu Satoshi; Matsui Kosuke; Kumar Himanshu; Kawai Taro; Iida Tetsuya; Honda Takeshi; Takeuchi Osamu; Akira Shizuo
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
The Journal of biological chemistry 2006;281(48):36897-904.
2006: Sato Kojiro; Suematsu Ayako; Okamoto Kazuo; Yamaguchi Akira; Morishita Yasuyuki; Kadono Yuho; Tanaka Sakae; Kodama Tatsuhiko; Akira Shizuo; Iwakura Yoichiro; Cua Daniel J; Takayanagi Hiroshi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
The Journal of experimental medicine 2006;203(12):2673-82.
2006: Koga Ritsuko; Hamano Shinjiro; Kuwata Hirotaka; Atarashi Koji; Ogawa Masahiro; Hisaeda Hajime; Yamamoto Masahiro; Akira Shizuo; Himeno Kunisuke; Matsumoto Makoto; Takeda Kiyoshi
TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7059-66.
2006: Matsui Kosuke; Kumagai Yutaro; Kato Hiroki; Sato Shintaro; Kawagoe Tatsukata; Uematsu Satoshi; Takeuchi Osamu; Akira Shizuo
Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5785-9.
2006: Hornung Veit; Ellegast Jana; Kim Sarah; Brzózka Krzysztof; Jung Andreas; Kato Hiroki; Poeck Hendrik; Akira Shizuo; Conzelmann Karl-Klaus; Schlee Martin; Endres Stefan; Hartmann Gunther
5'-Triphosphate RNA is the ligand for RIG-I.
Science (New York, N.Y.) 2006;314(5801):994-7.
2006: Power M R; Marshall J S; Yamamoto M; Akira S; Lin T-J
The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice.
Clinical and experimental immunology 2006;146(2):323-9.
2006: Amer Amal; Franchi Luigi; Kanneganti Thirumala-Devi; Body-Malapel Mathilde; Ozören Nesrin; Brady Graham; Meshinchi Sasha; Jagirdar Rajesh; Gewirtz Andrew; Akira Shizuo; Núñez Gabriel
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.
The Journal of biological chemistry 2006;281(46):35217-23.
2006: Togbe Dieudonnée; Aurore Gorse; Noulin Nicolas; Quesniaux Valérie F J; Schnyder-Candrian Silvia; Schnyder Bruno; Vasseur Virginie; Akira Shizuo; Hoebe Kasper; Beutler Bruce; Ryffel Bernhard; Couillin Isabelle
Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways.
Laboratory investigation; a journal of technical methods and pathology 2006;86(11):1126-35.
2006: Ishii Ken J; Akira Shizuo
Innate immune recognition of, and regulation by, DNA.
Trends in immunology 2006;27(11):525-32.
2006: Montminy Sara W; Khan Naseema; McGrath Sara; Walkowicz Mitchell J; Sharp Fiona; Conlon Joseph E; Fukase Koichi; Kusumoto Shoichi; Sweet Charles; Miyake Kensuke; Akira Shizuo; Cotter Robert J; Goguen Jon D; Lien Egil
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.
Nature immunology 2006;7(10):1066-73.
2006: Sato Shintaro; Sanjo Hideki; Tsujimura Tohru; Ninomiya-Tsuji Jun; Yamamoto Masahiro; Kawai Taro; Takeuchi Osamu; Akira Shizuo
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
International immunology 2006;18(10):1405-11.
2006: Wuest Todd; Austin Bobbie Ann; Uematsu Satoshi; Thapa Manoj; Akira Shizuo; Carr Daniel J J
Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.
Journal of neuroimmunology 2006;179(1-2):46-52.
2006: Bai Tao; Tanaka Tetsuji; Yukawa Kazunori; Umesaki Naohiko; Matsumoto Makoto; Akira Shizuo
Impaired postnatal development in C/EBPbeta-deficient mice.
The Journal of reproduction and development 2006;52(5):645-9.
2006: Shimada Naohiko; Ishii Ken J; Takeda Yoichi; Coban Cevayir; Torii Yuichi; Shinkai Seiji; Akira Shizuo; Sakurai Kazuo
Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier.
Bioconjugate chemistry 2006;17(5):1136-40.
2006: Berland Robert; Fernandez Luis; Kari Elina; Han Jin-Hwan; Lomakin Ina; Akira Shizuo; Wortis Henry H; Kearney John F; Ucci Angelo A; Imanishi-Kari Thereza
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice.
Immunity 2006;25(3):429-40.
2006: Lang Karl S; Georgiev Panco; Recher Mike; Navarini Alexander A; Bergthaler Andreas; Heikenwalder Mathias; Harris Nicola L; Junt Tobias; Odermatt Bernhard; Clavien Pierre-Alain; Pircher Hanspeter; Akira Shizuo; Hengartner Hans; Zinkernagel Rolf M
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
The Journal of clinical investigation 2006;116(9):2456-63.
2006: Uematsu Satoshi; Akira Shizuo
Toll-like receptors and innate immunity.
Journal of molecular medicine (Berlin, Germany) 2006;84(9):712-25.
2006: Kamon Hokuto; Kawabe Takaya; Kitamura Hidemitsu; Lee Jihye; Kamimura Daisuke; Kaisho Tsuneyasu; Akira Shizuo; Iwamatsu Akihiro; Koga Hisashi; Murakami Masaaki; Hirano Toshio
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation.
The EMBO journal 2006;25(17):4108-19.
2006: Huangfu Wei-Chun; Omori Emily; Akira Shizuo; Matsumoto Kunihiro; Ninomiya-Tsuji Jun
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
The Journal of biological chemistry 2006;281(39):28802-10.
2006: Kitamura Hidemitsu; Morikawa Hideyuki; Kamon Hokuto; Iguchi Megumi; Hojyo Shintaro; Fukada Toshiyuki; Yamashita Susumu; Kaisho Tsuneyasu; Akira Shizuo; Murakami Masaaki; Hirano Toshio
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
Nature immunology 2006;7(9):971-7.
2006: Yamamoto Masahiro; Okamoto Toru; Takeda Kiyoshi; Sato Shintaro; Sanjo Hideki; Uematsu Satoshi; Saitoh Tatsuya; Yamamoto Naoki; Sakurai Hiroaki; Ishii Ken J; Yamaoka Shoji; Kawai Taro; Matsuura Yoshiharu; Takeuchi Osamu; Akira Shizuo
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nature immunology 2006;7(9):962-70.
2006: Kim Leesun; Butcher Barbara A; Lee Chiang W; Uematsu Satoshi; Akira Shizuo; Denkers Eric Y
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2584-91.
2006: Chen Chun-Jen; Shi Yan; Hearn Arron; Fitzgerald Kate; Golenbock Douglas; Reed George; Akira Shizuo; Rock Kenneth L
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
The Journal of clinical investigation 2006;116(8):2262-71.
2006: Shirakawa Ken; Maeda Shingo; Gotoh Tomomi; Hayashi Makoto; Shinomiya Kenichi; Ehata Shogo; Nishimura Riko; Mori Masataka; Onozaki Kikuo; Hayashi Hidetoshi; Uematsu Satoshi; Akira Shizuo; Ogata Etsuro; Miyazono Kohei; Imamura Takeshi
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.
Molecular and cellular biology 2006;26(16):6105-16.
2006: Ikeda-Matsuo Yuri; Ota Azusa; Fukada Tetsuya; Uematsu Satoshi; Akira Shizuo; Sasaki Yasuharu
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11790-5.
2006: Inada Masaki; Matsumoto Chiho; Uematsu Satoshi; Akira Shizuo; Miyaura Chisato
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1879-85.
2006: Uematsu Satoshi; Jang Myoung Ho; Chevrier Nicolas; Guo Zijin; Kumagai Yutaro; Yamamoto Masahiro; Kato Hiroki; Sougawa Nagako; Matsui Hidenori; Kuwata Hirotaka; Hemmi Hiroaki; Coban Cevayir; Kawai Taro; Ishii Ken J; Takeuchi Osamu; Miyasaka Masayuki; Takeda Kiyoshi; Akira Shizuo
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Nature immunology 2006;7(8):868-74.
2006: Fink Katja; Lang Karl S; Manjarrez-Orduno Nataly; Junt Tobias; Senn Beatrice M; Holdener Martin; Akira Shizuo; Zinkernagel Rolf M; Hengartner Hans
Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.
European journal of immunology 2006;36(8):2094-105.
2006: Kawai Taro; Akira Shizuo
[Role of IPS-1 in type I IFN induction]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(7):1231-5.
2006: Kato Hiroki; Takeuchi Osamu; Akira Shizuo
[Cell type specific involvement of RIG-I in antiviral responses]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(7):1244-7.
2006: Behera Aruna K; Hildebrand Ethan; Uematsu Satoshi; Akira Shizuo; Coburn Jenifer; Hu Linden T
Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):657-64.
2006: Jeyaseelan Samithamby; Young Scott K; Yamamoto Masahiro; Arndt Patrick G; Akira Shizuo; Kolls Jay K; Worthen G Scott
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):538-47.
2006: Kumar Himanshu; Kawai Taro; Kato Hiroki; Sato Shintaro; Takahashi Ken; Coban Cevayir; Yamamoto Masahiro; Uematsu Satoshi; Ishii Ken J; Takeuchi Osamu; Akira Shizuo
Essential role of IPS-1 in innate immune responses against RNA viruses.
The Journal of experimental medicine 2006;203(7):1795-803.
2006: Takeshita Fumihiko; Tanaka Toshiyuki; Matsuda Tomoko; Tozuka Miyuki; Kobiyama Kouji; Saha Sukumar; Matsui Kiyohiko; Ishii Ken J; Coban Cevayir; Akira Shizuo; Ishii Norihisa; Suzuki Koichi; Klinman Dennis M; Okuda Kenji; Sasaki Shin
Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity.
Journal of virology 2006;80(13):6218-24.
2006: Cottalorda Anne; Verschelde Claire; Marçais Antoine; Tomkowiak Martine; Musette Philippe; Uematsu Satoshi; Akira Shizuo; Marvel Jacqueline; Bonnefoy-Berard Nathalie
TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation.
European journal of immunology 2006;36(7):1684-93.
2006: Qin Jinzhong; Yao Jianhong; Cui Grace; Xiao Hui; Kim Tae Whan; Fraczek Jerzy; Wightman Paul; Sato Shintaro; Akira Shizuo; Puel Anne; Casanova Jean-Laurent; Su Bing; Li Xiaoxia
TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.
The Journal of biological chemistry 2006;281(30):21013-21.
2006: Yoshimatsu Takeshi; Kawaguchi Daichi; Oishi Koji; Takeda Kiyoshi; Akira Shizuo; Masuyama Norihisa; Gotoh Yukiko
Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex.
Development (Cambridge, England) 2006;133(13):2553-63.
2006: Omori Emily; Matsumoto Kunihiro; Sanjo Hideki; Sato Shintaro; Akira Shizuo; Smart Robert C; Ninomiya-Tsuji Jun
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis.
The Journal of biological chemistry 2006;281(28):19610-7.
2006: Rumio Cristiano; Besusso Dario; Arnaboldi Francesca; Palazzo Marco; Selleri Silvia; Gariboldi Silvia; Akira Shizuo; Uematsu Satoshi; Bignami Paola; Ceriani Valerio; Ménard Sylvie; Balsari Andrea
Activation of smooth muscle and myenteric plexus cells of jejunum via Toll-like receptor 4.
Journal of cellular physiology 2006;208(1):47-54.
2006: Uematsu Satoshi; Akira Shizuo
[Innate immune recognition of viral infection]
Uirusu. Journal of virology 2006;56(1):1-8.
2006: Uematsu Satoshi; Akira Shizuo
[Innate immunity and toll-like receptor]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(6):1115-21.
2006: Nagai Yoshinori; Garrett Karla P; Ohta Shoichiro; Bahrun Uleng; Kouro Taku; Akira Shizuo; Takatsu Kiyoshi; Kincade Paul W
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity 2006;24(6):801-12.
2006: Miyatsuka Takeshi; Kaneto Hideaki; Shiraiwa Toshihiko; Matsuoka Taka-aki; Yamamoto Kaoru; Kato Ken; Nakamura Yumiko; Akira Shizuo; Takeda Kiyoshi; Kajimoto Yoshitaka; Yamasaki Yoshimitsu; Sandgren Eric P; Kawaguchi Yoshiya; Wright Christopher V E; Fujitani Yoshio
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.
Genes & development 2006;20(11):1435-40.
2006: Netea Mihai G; Joosten Leo A B; Lewis Eli; Jensen Dalan R; Voshol Peter J; Kullberg Bart Jan; Tack Cees J; van Krieken Han; Kim Soo-Hyun; Stalenhoef Anton F; van de Loo Fons A; Verschueren Ineke; Pulawa Leslie; Akira Shizuo; Eckel Robert H; Dinarello Charles A; van den Berg Wim; van der Meer Jos W M
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.
Nature medicine 2006;12(6):650-6.
2006: Takegahara Noriko; Takamatsu Hyota; Toyofuku Toshihiko; Tsujimura Tohru; Okuno Tatsusada; Yukawa Kazunori; Mizui Masayuki; Yamamoto Midori; Prasad Durbaka V R; Suzuki Kazuhiro; Ishii Masaru; Terai Kenta; Moriya Masayuki; Nakatsuji Yuji; Sakoda Saburo; Sato Shintaro; Akira Shizuo; Takeda Kiyoshi; Inui Masanori; Takai Toshiyuki; Ikawa Masahito; Okabe Masaru; Kumanogoh Atsushi; Kikutani Hitoshi
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Nature cell biology 2006;8(6):615-22.
2006: Nakamura Kiwamu; Miyagi Kazuya; Koguchi Yoshinobu; Kinjo Yuki; Uezu Kaori; Kinjo Takeshi; Akamine Morikazu; Fujita Jiro; Kawamura Ikuo; Mitsuyama Masao; Adachi Yoshiyuki; Ohno Naohito; Takeda Kiyoshi; Akira Shizuo; Miyazato Akiko; Kaku Mitsuo; Kawakami Kazuyoshi
Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans.
FEMS immunology and medical microbiology 2006;47(1):148-54.
2006: Saitoh Tatsuya; Tun-Kyi Adrian; Ryo Akihide; Yamamoto Masahiro; Finn Greg; Fujita Takashi; Akira Shizuo; Yamamoto Naoki; Lu Kun Ping; Yamaoka Shoji
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
Nature immunology 2006;7(6):598-605.
2006: Schellack Carola; Prinz Karin; Egyed Alena; Fritz Jörg H; Wittmann Barbara; Ginzler Michael; Swatosch Gabriele; Zauner Wolfgang; Kast Constantia; Akira Shizuo; von Gabain Alexander; Buschle Michael; Lingnau Karen
IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.
Vaccine 2006;24(26):5461-72.
2006: Takahashi Yuji; Isuzugawa Kazuto; Murase Yasunori; Imai Misa; Yamamoto Shinya; Iizuka Masateru; Akira Shizuo; Bahr George M; Momotani Ei-Ichi; Hori Masatoshi; Ozaki Hiroshi; Imakawa Kazuhiko
Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2006;68(5):471-8.
2006: Sumikawa Yasuyuki; Asada Hideo; Hoshino Katsuaki; Azukizawa Hiroaki; Katayama Ichiro; Akira Shizuo; Itami Satoshi
Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2.
Microbes and infection / Institut Pasteur 2006;8(6):1513-21.
2006: Kaisho Tsuneyasu; Akira Shizuo
Toll-like receptor function and signaling.
The Journal of allergy and clinical immunology 2006;117(5):979-87; quiz 988.
2006: Endo Motoyoshi; Mori Masataka; Akira Shizuo; Gotoh Tomomi
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6245-53.
2006: Kelly Kindra M; Zhuang Haoyang; Nacionales Dina C; Scumpia Philip O; Lyons Robert; Akaogi Jun; Lee Pui; Williams Bryan; Yamamoto Masahiro; Akira Shizuo; Satoh Minoru; Reeves Westley H
"Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
Arthritis and rheumatism 2006;54(5):1557-67.
2006: Kato Hiroki; Takeuchi Osamu; Sato Shintaro; Yoneyama Mitsutoshi; Yamamoto Masahiro; Matsui Kosuke; Uematsu Satoshi; Jung Andreas; Kawai Taro; Ishii Ken J; Yamaguchi Osamu; Otsu Kinya; Tsujimura Tohru; Koh Chang-Sung; Reis e Sousa Caetano; Matsuura Yoshiharu; Fujita Takashi; Akira Shizuo
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature 2006;441(7089):101-5.
2006: Barrier Mathieu; Lacroix-Lamandé Sonia; Mancassola Roselyne; Auray Gaël; Bernardet Nelly; Chaussé Anne-Marie; Uematsu Satoshi; Akira Shizuo; Laurent Fabrice
Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice.
The Journal of infectious diseases 2006;193(10):1400-7.
2006: Yukawa Kazunori; Tanaka Tetsuji; Bai Tao; Li Li; Tsubota Yuji; Owada-Makabe Kyoko; Maeda Masanobu; Hoshino Katsuaki; Akira Shizuo; Iso Hiroyuki
Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice.
International journal of molecular medicine 2006;17(5):869-73.
2006: Kawai T; Akira S
TLR signaling.
Cell death and differentiation 2006;13(5):816-25.
2006: Hoshino Katsuaki; Sugiyama Takahiro; Matsumoto Mitsuru; Tanaka Takashi; Saito Masuyoshi; Hemmi Hiroaki; Ohara Osamu; Akira Shizuo; Kaisho Tsuneyasu
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.
Nature 2006;440(7086):949-53.
2006: Rowe Daniel C; McGettrick Anne F; Latz Eicke; Monks Brian G; Gay Nicholas J; Yamamoto Masahiro; Akira Shizuo; O'Neill Luke A; Fitzgerald Katherine A; Golenbock Douglas T
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6299-304.
2006: Takahashi Ken; Kawai Taro; Kumar Himanshu; Sato Shintaro; Yonehara Shin; Akira Shizuo
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4520-4.
2006: Inoue Hiroshi; Ogawa Wataru; Asakawa Akihiro; Okamoto Yasuo; Nishizawa Akihiko; Matsumoto Michihiro; Teshigawara Kiyoshi; Matsuki Yasushi; Watanabe Eijiro; Hiramatsu Ryuji; Notohara Kenji; Katayose Koji; Okamura Hitoshi; Kahn C Ronald; Noda Tetsuo; Takeda Kiyoshi; Akira Shizuo; Inui Akio; Kasuga Masato
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
Cell metabolism 2006;3(4):267-75.
2006: Kinoshita Dan; Hirota Fumiko; Kaisho Tsuneyasu; Kasai Michiyuki; Izumi Keisuke; Bando Yoshimi; Mouri Yasuhiro; Matsushima Akemi; Niki Shino; Han Hongwei; Oshikawa Kiyotaka; Kuroda Noriyuki; Maegawa Masahiko; Irahara Minoru; Takeda Kiyoshi; Akira Shizuo; Matsumoto Mitsuru
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):3995-4002.
2006: Santos Leilani L; Milenkovski Georgia P; Hall Pamela H; Leech Michelle; Sharma Laveena; Takeda Kiyoshi; Akira Shizuo; Kitching A Richard; Morand Eric F
IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis.
Immunology and cell biology 2006;84(2):166-73.
2006: Buwitt-Beckmann Ute; Heine Holger; Wiesmüller Karl-Heinz; Jung Günther; Brock Roland; Akira Shizuo; Ulmer Artur J
TLR1- and TLR6-independent recognition of bacterial lipopeptides.
The Journal of biological chemistry 2006;281(14):9049-57.
2006: Savarese Emina; Chae Ohk-wha; Trowitzsch Simon; Weber Gert; Kastner Berthold; Akira Shizuo; Wagner Hermann; Schmid Roland M; Bauer Stefan; Krug Anne
U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.
Blood 2006;107(8):3229-34.
2006: Oshikawa Tetsuya; Okamoto Masato; Tano Tomoyuki; Sasai Akiko; Kan Shin; Moriya Yoichiro; Ryoma Yoshiki; Saito Motoo; Akira Shizuo; Sato Mitsunobu
Antitumor effect of OK-432-derived DNA: one of the active constituents of OK-432, a streptococcal immunotherapeutic agent.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(2):143-50.
2006: Bhattacharjee Rabindra N; Akira Shizuo
Modifying toll-like receptor 9 signaling for therapeutic use.
Mini reviews in medicinal chemistry 2006;6(3):287-91.
2006: Uematsu Satoshi; Akira Shizuo
The role of Toll-like receptors in immune disorders.
Expert opinion on biological therapy 2006;6(3):203-14.
2006: Behera Aruna K; Hildebrand Ethan; Bronson Roderick T; Perides George; Uematsu Satoshi; Akira Shizuo; Hu Linden T
MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi.
Infection and immunity 2006;74(3):1462-70.
2006: Lapaque Nicolas; Takeuchi Osamu; Corrales Fernando; Akira Shizuo; Moriyon Ignacio; Howard Jonathan C; Gorvel Jean-Pierre
Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.
Cellular microbiology 2006;8(3):401-13.
2006: Uemura Noriyuki; Kajino Taisuke; Sanjo Hideki; Sato Shintaro; Akira Shizuo; Matsumoto Kunihiro; Ninomiya-Tsuji Jun
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
The Journal of biological chemistry 2006;281(12):7863-72.
2006: Kanneganti Thirumala-Devi; Ozören Nesrin; Body-Malapel Mathilde; Amer Amal; Park Jong-Hwan; Franchi Luigi; Whitfield Joel; Barchet Winfried; Colonna Marco; Vandenabeele Peter; Bertin John; Coyle Anthony; Grant Ethan P; Akira Shizuo; Núñez Gabriel
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Nature 2006;440(7081):233-6.
2006: Suram Saritha; Brown Gordon D; Ghosh Moumita; Gordon Siamon; Loper Robyn; Taylor Philip R; Akira Shizuo; Uematsu Satoshi; Williams David L; Leslie Christina C
Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor.
The Journal of biological chemistry 2006;281(9):5506-14.
2006: Sato Noriko; Kamada Nobuyuki; Muromoto Ryuta; Kawai Taro; Sugiyama Kenji; Watanabe Tadashi; Imoto Seiyu; Sekine Yuichi; Ohbayashi Norihiko; Ishida Masato; Akira Shizuo; Matsuda Tadashi
Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.
Immunology letters 2006;103(2):127-34.
2006: Akira Shizuo; Uematsu Satoshi; Takeuchi Osamu
Pathogen recognition and innate immunity.
Cell 2006;124(4):783-801.
2006: Zhu Ping; Baek Sung Hee; Bourk Eliot M; Ohgi Kenneth A; Garcia-Bassets Ivan; Sanjo Hideki; Akira Shizuo; Kotol Paul F; Glass Christopher K; Rosenfeld Michael G; Rose David W
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
Cell 2006;124(3):615-29.
2006: Querec Troy; Bennouna Soumaya; Alkan Sefik; Laouar Yasmina; Gorden Keith; Flavell Richard; Akira Shizuo; Ahmed Rafi; Pulendran Bali
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.
The Journal of experimental medicine 2006;203(2):413-24.
2006: Sutmuller Roger P M; den Brok Martijn H M G M; Kramer Matthijs; Bennink Erik J; Toonen Liza W J; Kullberg Bart-Jan; Joosten Leo A; Akira Shizuo; Netea Mihai G; Adema Gosse J
Toll-like receptor 2 controls expansion and function of regulatory T cells.
The Journal of clinical investigation 2006;116(2):485-94.
2006: Kawai Taro; Akira Shizuo
Innate immune recognition of viral infection.
Nature immunology 2006;7(2):131-7.
2006: Kiura Kazuto; Kataoka Hideo; Nakata Takashi; Into Takeshi; Yasuda Motoaki; Akira Shizuo; Inoue Nobuo; Shibata Ken-ichiro
The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through Toll-like receptor 2.
FEMS immunology and medical microbiology 2006;46(1):78-84.
2006: Fischer Hans; Yamamoto Masahiro; Akira Shizuo; Beutler Bruce; Svanborg Catharina
Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection.
European journal of immunology 2006;36(2):267-77.
2006: Marty René R; Dirnhofer Stephan; Mauermann Nora; Schweikert Sacha; Akira Shizuo; Hunziker Lukas; Penninger Josef M; Eriksson Urs
MyD88 signaling controls autoimmune myocarditis induction.
Circulation 2006;113(2):258-65.
2006: Wan Jun; Zhang Wei; Wu Liming; Bai Ting; Zhang Mingjie; Lo Kwok-Wai; Chui Yiu-Loon; Cui Yan; Tao Qian; Yamamoto Masahiro; Akira Shizuo; Wu Zhenguo
BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway.
Molecular and cellular biology 2006;26(2):448-56.
2006: Sekine Yuichi; Yumioka Taro; Yamamoto Tetsuya; Muromoto Ryuta; Imoto Seiyu; Sugiyma Kenji; Oritani Kenji; Shimoda Kazuya; Minoguchi Mayu; Akira Shizuo; Yoshimura Akihiko; Matsuda Tadashi
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):380-9.
2006: Wingender Gerhard; Garbi Natalio; Schumak Beatrix; Jüngerkes Frank; Endl Elmar; von Bubnoff Dagmar; Steitz Julia; Striegler Jörg; Moldenhauer Gerd; Tüting Thomas; Heit Antje; Huster Katharina M; Takikawa Osamu; Akira Shizuo; Busch Dirk H; Wagner Hermann; Hämmerling Günter J; Knolle Percy A; Limmer Andreas
Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO.
European journal of immunology 2006;36(1):12-20.
2006: Ishii Ken J; Coban Cevayir; Kato Hiroki; Takahashi Ken; Torii Yuichi; Takeshita Fumihiko; Ludwig Holger; Sutter Gerd; Suzuki Koichi; Hemmi Hiroaki; Sato Shintaro; Yamamoto Masahiro; Uematsu Satoshi; Kawai Taro; Takeuchi Osamu; Akira Shizuo
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nature immunology 2006;7(1):40-8.
2006: Knapp Sylvia; Wieland Catharina W; Florquin Sandrine; Pantophlet Ralph; Dijkshoorn Lenie; Tshimbalanga Ntambua; Akira Shizuo; van der Poll Tom
Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia.
American journal of respiratory and critical care medicine 2006;173(1):122-9.
2006: Ogawa A; Tagawa T; Nishimura H; Yajima T; Abe T; Arai T; Taniguchi M; Takeda K; Akira S; Nimura Y; Yoshikai Y
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Gut 2006;55(1):105-13.
2006: Busconi Liliana; Lau Christina M; Tabor Abigail S; Uccellini Melissa B; Ruhe Zachary; Akira Shizuo; Viglianti Gregory A; Rifkin Ian R; Marshak-Rothstein Ann
DNA and RNA autoantigens as autoadjuvants.
Journal of endotoxin research 2006;12(6):379-84.
2006: Ishii Ken J; Uematsu Satoshi; Akira Shizuo
'Toll' gates for future immunotherapy.
Current pharmaceutical design 2006;12(32):4135-42.
2006: Akira S
TLR signaling.
Current topics in microbiology and immunology 2006;311():1-16.
2005: Vollmer Jörg; Tluk Sibylle; Schmitz Claudia; Hamm Svetlana; Jurk Marion; Forsbach Alexandra; Akira Shizuo; Kelly Kindra M; Reeves Westley H; Bauer Stefan; Krieg Arthur M
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.
The Journal of experimental medicine 2005;202(11):1575-85.
2005: Poonepalli Anuradha; Balakrishnan Lakshmidevi; Khaw Aik Kia; Low Grace Kah Mun; Jayapal Manikandan; Bhattacharjee Rabindra N; Akira Shizuo; Balajee Adayabalam S; Hande M Prakash
Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite.
Cancer research 2005;65(23):10977-83.
2005: Jeyaseelan Samithamby; Manzer Rizwan; Young Scott K; Yamamoto Masahiro; Akira Shizuo; Mason Robert J; Worthen G Scott
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7484-95.
2005: Bhattacharjee Rabindra N; Park Kwon-Sam; Uematsu Satoshi; Okada Kazuhisa; Hoshino Katsuaki; Takeda Kiyoshi; Takeuchi Osamu; Akira Shizuo; Iida Tetsuya; Honda Takeshi
Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
FEBS letters 2005;579(29):6604-10.
2005: Sato Noriko; Kawai Taro; Sugiyama Kenji; Muromoto Ryuta; Imoto Seiyu; Sekine Yuichi; Ishida Masato; Akira Shizuo; Matsuda Tadashi
Physical and functional interactions between STAT3 and ZIP kinase.
International immunology 2005;17(12):1543-52.
2005: Ishii Ken J; Coban Cevayir; Akira Shizuo
Manifold mechanisms of Toll-like receptor-ligand recognition.
Journal of clinical immunology 2005;25(6):511-21.
2005: Okabe Yasutaka; Kawane Kohki; Akira Shizuo; Taniguchi Tadatsugu; Nagata Shigekazu
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.
The Journal of experimental medicine 2005;202(10):1333-9.
2005: Kimura Akihiro; Naka Tetsuji; Muta Tatsushi; Takeuchi Osamu; Akira Shizuo; Kawase Ichiro; Kishimoto Tadamitsu
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17089-94.
2005: Delale Thomas; Paquin André; Asselin-Paturel Carine; Dalod Marc; Brizard Géraldine; Bates Elizabeth E M; Kastner Philippe; Chan Susan; Akira Shizuo; Vicari Alain; Biron Christine A; Trinchieri Giorgio; Brière Francine
MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6723-32.
2005: Shim Jae-Hyuck; Xiao Changchun; Paschal Amber E; Bailey Shannon T; Rao Ping; Hayden Matthew S; Lee Ki-Young; Bussey Crystal; Steckel Michael; Tanaka Nobuyuki; Yamada Gen; Akira Shizuo; Matsumoto Kunihiro; Ghosh Sankar
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
Genes & development 2005;19(22):2668-81.
2005: Lau Christina M; Broughton Courtney; Tabor Abigail S; Akira Shizuo; Flavell Richard A; Mamula Mark J; Christensen Sean R; Shlomchik Mark J; Viglianti Gregory A; Rifkin Ian R; Marshak-Rothstein Ann
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
The Journal of experimental medicine 2005;202(9):1171-7.
2005: Wieland Catharina W; Florquin Sandrine; Maris Nico A; Hoebe Kasper; Beutler Bruce; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6042-9.
2005: Sato Shintaro; Sanjo Hideki; Takeda Kiyoshi; Ninomiya-Tsuji Jun; Yamamoto Masahiro; Kawai Taro; Matsumoto Kunihiro; Takeuchi Osamu; Akira Shizuo
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nature immunology 2005;6(11):1087-95.
2005: Haga Sanae; Ogawa Wataru; Inoue Hiroshi; Terui Keita; Ogino Tetsuya; Igarashi Rumi; Takeda Kiyoshi; Akira Shizuo; Enosawa Shin; Furukawa Hiroyuki; Todo Satoru; Ozaki Michitaka
Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice.
Journal of hepatology 2005;43(5):799-807.
2005: Ishii Ken J; Akira Shizuo
Innate immune recognition of nucleic acids: beyond toll-like receptors.
International journal of cancer. Journal international du cancer 2005;117(4):517-23.
2005: Barrat Franck J; Meeker Thea; Gregorio Josh; Chan Jean H; Uematsu Satoshi; Akira Shizuo; Chang Bonnie; Duramad Omar; Coffman Robert L
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.
The Journal of experimental medicine 2005;202(8):1131-9.
2005: Fuse Koichi; Chan Grace; Liu Youan; Gudgeon Patrick; Husain Mansoor; Chen Manyin; Yeh Wen-Chen; Akira Shizuo; Liu Peter P
Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production.
Circulation 2005;112(15):2276-85.
2005: Rothenfusser Simon; Goutagny Nadege; DiPerna Gary; Gong Mei; Monks Brian G; Schoenemeyer Annett; Yamamoto Masahiro; Akira Shizuo; Fitzgerald Katherine A
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5260-8.
2005: Baratin Myriam; Roetynck Sophie; Lépolard Catherine; Falk Christine; Sawadogo Serge; Uematsu Satoshi; Akira Shizuo; Ryffel Bernhard; Tiraby Jean-Gérard; Alexopoulou Lena; Kirschning Carsten J; Gysin Jürg; Vivier Eric; Ugolini Sophie
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14747-52.
2005: Leemans Jaklien C; Stokman Geurt; Claessen Nike; Rouschop Kasper M; Teske Gwendoline J D; Kirschning Carsten J; Akira Shizuo; van der Poll Tom; Weening Jan J; Florquin Sandrine
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney.
The Journal of clinical investigation 2005;115(10):2894-903.
2005: Yukawa Kazunori; Tanaka Tetsuji; Owada-Makabe Kyoko; Tsubota Yuji; Bai Tao; Maeda Masanobu; Takeda Kiyoshi; Akira Shizuo; Iso Hiroyuki
Reduced prepulse inhibition of startle in STAT6-deficient mice.
International journal of molecular medicine 2005;16(4):673-5.
2005: Kawai Taro; Takahashi Ken; Sato Shintaro; Coban Cevayir; Kumar Himanshu; Kato Hiroki; Ishii Ken J; Takeuchi Osamu; Akira Shizuo
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nature immunology 2005;6(10):981-8.
2005: Rasschaert Joanne; Ladrière Laurence; Urbain Maryse; Dogusan Zeynep; Katabua Bitty; Sato Shintaro; Akira Shizuo; Gysemans Conny; Mathieu Chantal; Eizirik Decio L
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
The Journal of biological chemistry 2005;280(40):33984-91.
2005: Kanemitsu Naotoshi; Ebisuno Yukihiko; Tanaka Toshiyuki; Otani Kazuhiro; Hayasaka Haruko; Kaisho Tsuneyasu; Akira Shizuo; Katagiri Koko; Kinashi Tatsuo; Fujita Naoya; Tsuruo Takashi; Miyasaka Masayuki
CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Blood 2005;106(8):2613-8.
2005: Huang Li-Yun; Ishii Ken J; Akira Shizuo; Aliberti Julio; Golding Basil
Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3964-70.
2005: Matsukawa Akihiro; Kudo Shinji; Maeda Takako; Numata Kousuke; Watanabe Hiroyuki; Takeda Kiyoshi; Akira Shizuo; Ito Takaaki
Stat3 in resident macrophages as a repressor protein of inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3354-9.
2005: Youn Hyung S; Lee Joo Y; Fitzgerald Katherine A; Young Howard A; Akira Shizuo; Hwang Daniel H
Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3339-46.
2005: Yoneyama Mitsutoshi; Kikuchi Mika; Matsumoto Kanae; Imaizumi Tadaatsu; Miyagishi Makoto; Taira Kazunari; Foy Eileen; Loo Yueh-Ming; Gale Michael; Akira Shizuo; Yonehara Shin; Kato Atsushi; Fujita Takashi
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2851-8.
2005: Balloy Viviane; Si-Tahar Mustapha; Takeuchi Osamu; Philippe Bruno; Nahori Marie-Anne; Tanguy Myriam; Huerre Michel; Akira Shizuo; Latgé Jean-Paul; Chignard Michel
Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis.
Infection and immunity 2005;73(9):5420-5.
2005: Yukawa Kazunori; Hoshino Katsuaki; Kishino Masanori; Tsubota Yuji; Owada-Makabe Kyoko; Maeda Masanobu; Bai Tao; Tanaka Tetsuji; Akira Shizuo
Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy.
International journal of molecular medicine 2005;16(3):389-93.
2005: Bhattacharjee Rabindra N; Park Kwon-Sam; Okada Kazuhisa; Kumagai Yutaro; Uematsu Satoshi; Takeuchi Osamu; Akira Shizuo; Iida Tetsuya; Honda Takeshi
Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.
Biochemical and biophysical research communications 2005;335(2):328-34.
2005: Amcheslavsky Alla; Hemmi Hiroaki; Akira Shizuo; Bar-Shavit Zvi
Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(9):1692-9.
2005: Ikeda-Matsuo Yuri; Ikegaya Yuji; Matsuki Norio; Uematsu Satoshi; Akira Shizuo; Sasaki Yasuharu
Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.
Journal of neurochemistry 2005;94(6):1546-58.
2005: Ishii Ken J; Akira Shizuo
TLR ignores methylated RNA?
Immunity 2005;23(2):111-3.
2005: Takeshita Fumihiko; Ishii Ken J; Kobiyama Kouji; Kojima Yoshitsugu; Coban Cevayir; Sasaki Shin; Ishii Norihisa; Klinman Dennis M; Okuda Kenji; Akira Shizuo; Suzuki Koichi
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.
European journal of immunology 2005;35(8):2477-85.
2005: Ishii Ken J; Ito Shuichi; Tamura Tomohiko; Hemmi Hiroaki; Conover Jacqueline; Ozato Keiko; Akira Shizuo; Klinman Dennis M
CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection.
European journal of immunology 2005;35(8):2397-405.
2005: Weiss David S; Takeda Kiyoshi; Akira Shizuo; Zychlinsky Arturo; Moreno Edgardo
MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus.
Infection and immunity 2005;73(8):5137-43.
2005: Mun Hye-Seong; Aosai Fumie; Norose Kazumi; Piao Lian-Xun; Fang Hao; Akira Shizuo; Yano Akihiko
Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70.
Infection and immunity 2005;73(8):4634-42.
2005: Yang Shuhua; Takahashi Naoyuki; Yamashita Teruhito; Sato Nobuaki; Takahashi Masahiro; Mogi Makio; Uematsu Takashi; Kobayashi Yasuhiro; Nakamichi Yuko; Takeda Kiyoshi; Akira Shizuo; Takada Haruhiko; Udagawa Nobuyuki; Furusawa Kiyofumi
Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1956-64.
2005: de Jonge Wouter J; van der Zanden Esmerij P; The Frans O; Bijlsma Maarten F; van Westerloo David J; Bennink Roelof J; Berthoud Hans-Rudolf; Uematsu Satoshi; Akira Shizuo; van den Wijngaard Rene M; Boeckxstaens Guy E
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Nature immunology 2005;6(8):844-51.
2005: Kawai Taro; Akira Shizuo
Pathogen recognition with Toll-like receptors.
Current opinion in immunology 2005;17(4):338-44.
2005: Kato Hiroki; Sato Shintaro; Yoneyama Mitsutoshi; Yamamoto Masahiro; Uematsu Satoshi; Matsui Kosuke; Tsujimura Tohru; Takeda Kiyoshi; Fujita Takashi; Takeuchi Osamu; Akira Shizuo
Cell type-specific involvement of RIG-I in antiviral response.
Immunity 2005;23(1):19-28.
2005: Christensen Sean R; Kashgarian Michael; Alexopoulou Lena; Flavell Richard A; Akira Shizuo; Shlomchik Mark J
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
The Journal of experimental medicine 2005;202(2):321-31.
2005: Shindou Hideo; Ishii Satoshi; Yamamoto Masahiro; Takeda Kiyoshi; Akira Shizuo; Shimizu Takao
Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1177-83.
2005: Kato Yuko; Iwama Atsushi; Tadokoro Yuko; Shimoda Kazuya; Minoguchi Mayu; Akira Shizuo; Tanaka Minoru; Miyajima Atsushi; Kitamura Toshio; Nakauchi Hiromitsu
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
The Journal of experimental medicine 2005;202(1):169-79.
2005: Boasen Jared; Chisholm Dugald; Lebet Lev; Akira Shizuo; Horner Anthony A
House dust extracts elicit Toll-like receptor-dependent dendritic cell responses.
The Journal of allergy and clinical immunology 2005;116(1):185-91.
2005: Kitching A Richard; Turner Amanda L; Wilson Gabrielle R A; Semple Timothy; Odobasic Dragana; Timoshanko Jennifer R; O'Sullivan Kim M; Tipping Peter G; Takeda Kiyoshi; Akira Shizuo; Holdsworth Stephen R
IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment.
Journal of the American Society of Nephrology : JASN 2005;16(7):2023-33.
2005: Yang Rongcun; Murillo Francisco Martinez; Delannoy Michael J; Blosser R Lee; Yutzy William H; Uematsu Satoshi; Takeda Kiyoshi; Akira Shizuo; Viscidi Raphael P; Roden Richard B S
B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7912-9.
2005: Uehori Junji; Fukase Koichi; Akazawa Takashi; Uematsu Satoshi; Akira Shizuo; Funami Kenji; Shingai Masashi; Matsumoto Misako; Azuma Ichiro; Toyoshima Kumao; Kusumoto Shoichi; Seya Tsukasa
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7096-103.
2005: Nagai Yoshinori; Kobayashi Toshihiko; Motoi Yuji; Ishiguro Kohtaroh; Akashi Sachiko; Saitoh Shin-ichiroh; Kusumoto Yutaka; Kaisho Tsuneyasu; Akira Shizuo; Matsumoto Mitsuru; Takatsu Kiyoshi; Miyake Kensuke
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7043-9.
2005: Hayashi Elize A; Akira Shizuo; Nobrega Alberto
Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6639-47.
2005: Yang Rongcun; Wheeler Cosette M; Chen Xiaojiang; Uematsu Satoshi; Takeda Kiyoshi; Akira Shizuo; Pastrana Diana V; Viscidi Raphael P; Roden Richard B S
Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.
Journal of virology 2005;79(11):6741-50.
2005: Jeyaseelan Samithamby; Manzer Rizwan; Young Scott K; Yamamoto Masahiro; Akira Shizuo; Mason Robert J; Worthen G Scott
Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium.
American journal of respiratory cell and molecular biology 2005;32(6):531-9.
2005: Henneke Philipp; Morath Siegfried; Uematsu Satoshi; Weichert Stefan; Pfitzenmaier Markus; Takeuchi Osamu; Müller Andrea; Poyart Claire; Akira Shizuo; Berner Reinhard; Teti Giuseppe; Geyer Armin; Hartung Thomas; Trieu-Cuot Patrick; Kasper Dennis L; Golenbock Douglas T
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6449-55.
2005: Mansur Daniel S; Kroon Erna G; Nogueira Maurício L; Arantes Rosa M E; Rodrigues Soraia C O; Akira Shizuo; Gazzinelli Ricardo T; Campos Marco A
Lethal encephalitis in myeloid differentiation factor 88-deficient mice infected with herpes simplex virus 1.
The American journal of pathology 2005;166(5):1419-26.
2005: Kishida Satoshi; Sanjo Hideki; Akira Shizuo; Matsumoto Kunihiro; Ninomiya-Tsuji Jun
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(5):447-54.
2005: Yukawa Kazunori; Iso Hiroyuki; Tanaka Tetsuji; Tsubota Yuji; Owada-Makabe Kyoko; Bai Tao; Takeda Kiyoshi; Akira Shizuo; Maeda Masanobu
Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice.
International journal of molecular medicine 2005;15(5):819-25.
2005: Asai Yasuyuki; Hashimoto Masahito; Fletcher Hansel M; Miyake Kensuke; Akira Shizuo; Ogawa Tomohiko
Lipopolysaccharide preparation extracted from Porphyromonas gingivalis lipoprotein-deficient mutant shows a marked decrease in toll-like receptor 2-mediated signaling.
Infection and immunity 2005;73(4):2157-63.
2005: Kalis Christoph; Gumenscheimer Marina; Freudenberg Nikolaus; Tchaptchet Sandrine; Fejer György; Heit Antje; Akira Shizuo; Galanos Chris; Freudenberg Marina A
Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4295-300.
2005: Breiman Adrien; Grandvaux Nathalie; Lin Rongtuan; Ottone Catherine; Akira Shizuo; Yoneyama Mitsutoshi; Fujita Takashi; Hiscott John; Meurs Eliane F
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
Journal of virology 2005;79(7):3969-78.
2005: Xu Allison Wanting; Kaelin Christopher B; Takeda Kiyoshi; Akira Shizuo; Schwartz Michael W; Barsh Gregory S
PI3K integrates the action of insulin and leptin on hypothalamic neurons.
The Journal of clinical investigation 2005;115(4):951-8.
2005: Suzuki Toshihiko; Nakanishi Kenji; Tsutsui Hiroko; Iwai Hiroki; Akira Shizuo; Inohara Naohiro; Chamaillard Mathias; Nuñez Gabriel; Sasakawa Chihiro
A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages.
The Journal of biological chemistry 2005;280(14):14042-50.
2005: Yoshitomi Hiroyuki; Sakaguchi Noriko; Kobayashi Katsuya; Brown Gordon D; Tagami Tomoyuki; Sakihama Toshiko; Hirota Keiji; Tanaka Satoshi; Nomura Takashi; Miki Ichiro; Gordon Siamon; Akira Shizuo; Nakamura Takashi; Sakaguchi Shimon
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.
The Journal of experimental medicine 2005;201(6):949-60.
2005: Kumanogoh Atsushi; Shikina Takashi; Suzuki Kazuhiro; Uematsu Satoshi; Yukawa Kazunori; Kashiwamura Shin-Ichiro; Tsutsui Hiroko; Yamamoto Midori; Takamatsu Hyota; Ko-Mitamura Elizabeth P; Takegahara Noriko; Marukawa Satoko; Ishida Isao; Morishita Hiroshi; Prasad Durbaka V R; Tamura Manabu; Mizui Masayuki; Toyofuku Toshihiko; Akira Shizuo; Takeda Kiyoshi; Okabe Masaru; Kikutani Hitoshi
Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.
Immunity 2005;22(3):305-16.
2005: Uematsu Satoshi; Sato Shintaro; Yamamoto Masahiro; Hirotani Tomonori; Kato Hiroki; Takeshita Fumihiko; Matsuda Michiyuki; Coban Cevayir; Ishii Ken J; Kawai Taro; Takeuchi Osamu; Akira Shizuo
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
The Journal of experimental medicine 2005;201(6):915-23.
2005: Hirotani Tomonori; Lee Pui Y; Kuwata Hirotaka; Yamamoto Masahiro; Matsumoto Makoto; Kawase Ichiro; Akira Shizuo; Takeda Kiyoshi
The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3650-7.
2005: Seki Ekihiro; Tsutsui Hiroko; Iimuro Yuji; Naka Tetsuji; Son Gakuhei; Akira Shizuo; Kishimoto Tadamitsu; Nakanishi Kenji; Fujimoto Jiro
Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration.
Hepatology (Baltimore, Md.) 2005;41(3):443-50.
2005: Hornung Veit; Guenthner-Biller Margit; Bourquin Carole; Ablasser Andrea; Schlee Martin; Uematsu Satoshi; Noronha Anne; Manoharan Muthiah; Akira Shizuo; de Fougerolles Antonin; Endres Stefan; Hartmann Gunther
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Nature medicine 2005;11(3):263-70.
2005: Abe Takayuki; Hemmi Hiroaki; Miyamoto Hironobu; Moriishi Kohji; Tamura Shinichi; Takaku Hiroshi; Akira Shizuo; Matsuura Yoshiharu
Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus.
Journal of virology 2005;79(5):2847-58.
2005: Hirotani Tomonori; Yamamoto Masahiro; Kumagai Yutaro; Uematsu Satoshi; Kawase Ichiro; Takeuchi Osamu; Akira Shizuo
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.
Biochemical and biophysical research communications 2005;328(2):383-92.
2005: Krishnegowda Gowdahalli; Hajjar Adeline M; Zhu Jianzhong; Douglass Erika J; Uematsu Satoshi; Akira Shizuo; Woods Amina S; Gowda D Channe
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.
The Journal of biological chemistry 2005;280(9):8606-16.
2005: Uematsu Satoshi; Akira Shizuo
[Role of toll-like receptor in immunological defence mechanism ]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2005;94(2):355-61.
2005: Sugiyama Takahiro; Gursel Mayda; Takeshita Fumihiko; Coban Cevayir; Conover Jacqueline; Kaisho Tsuneyasu; Akira Shizuo; Klinman Dennis M; Ishii Ken J
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2273-9.
2005: Ueta Mayumi; Hamuro Junji; Yamamoto Masahiro; Kaseda Kazuhiro; Akira Shizuo; Kinoshita Shigeru
Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice.
Investigative ophthalmology & visual science 2005;46(2):579-88.
2005: Kamezaki Kenjirou; Shimoda Kazuya; Numata Akihiko; Haro Takashi; Kakumitsu Haruko; Yoshie Masumi; Yamamoto Masahiro; Takeda Kiyoshi; Matsuda Tadashi; Akira Shizuo; Ogawa Katsuhiro; Harada Mine
Roles of Stat3 and ERK in G-CSF signaling.
Stem cells (Dayton, Ohio) 2005;23(2):252-63.
2005: Hapfelmeier Siegfried; Stecher Bärbel; Barthel Manja; Kremer Marcus; Müller Andreas J; Heikenwalder Mathias; Stallmach Thomas; Hensel Michael; Pfeffer Klaus; Akira Shizuo; Hardt Wolf-Dietrich
The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1675-85.
2005: Saitoh Tatsuya; Yamamoto Masahiro; Miyagishi Makoto; Taira Kazunari; Nakanishi Makoto; Fujita Takashi; Akira Shizuo; Yamamoto Naoki; Yamaoka Shoji
A20 is a negative regulator of IFN regulatory factor 3 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1507-12.
2005: Lang Karl S; Recher Mike; Junt Tobias; Navarini Alexander A; Harris Nicola L; Freigang Stefan; Odermatt Bernhard; Conrad Curdin; Ittner Lars M; Bauer Stefan; Luther Sanjiv A; Uematsu Satoshi; Akira Shizuo; Hengartner Hans; Zinkernagel Rolf M
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Nature medicine 2005;11(2):138-45.
2005: Säemann Marcus D; Weichhart Thomas; Zeyda Maximilian; Staffler Günther; Schunn Michael; Stuhlmeier Karl M; Sobanov Yuri; Stulnig Thomas M; Akira Shizuo; von Gabain Alexander; von Ahsen Uwe; Hörl Walter H; Zlabinger Gerhard J
Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism.
The Journal of clinical investigation 2005;115(2):468-75.
2005: Yukawa Kazunori; Kishino Masanori; Goda Mikako; Liang Xiang-Ming; Kimura Akihiko; Tanaka Tetsuji; Bai Tao; Owada-Makabe Kyoko; Tsubota Yuji; Ueyama Takashi; Ichinose Masakazu; Maeda Masanobu; Takeda Kiyoshi; Akira Shizuo
STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.
International journal of molecular medicine 2005;15(2):225-30.
2005: Guillot Loïc; Le Goffic Ronan; Bloch Sarah; Escriou Nicolas; Akira Shizuo; Chignard Michel; Si-Tahar Mustapha
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
The Journal of biological chemistry 2005;280(7):5571-80.
2005: Oishi Yumiko; Manabe Ichiro; Tobe Kazuyuki; Tsushima Kensuke; Shindo Takayuki; Fujiu Katsuhito; Nishimura Go; Maemura Koji; Yamauchi Toshimasa; Kubota Naoto; Suzuki Ryo; Kitamura Toshio; Akira Shizuo; Kadowaki Takashi; Nagai Ryozo
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Cell metabolism 2005;1(1):27-39.
2005: Araki Akihiro; Kanai Takanori; Ishikura Takahiro; Makita Shin; Uraushihara Koji; Iiyama Ryoichi; Totsuka Teruji; Takeda Kiyoshi; Akira Shizuo; Watanabe Mamoru
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
Journal of gastroenterology 2005;40(1):16-23.
2005: Coban Cevayir; Ishii Ken J; Kawai Taro; Hemmi Hiroaki; Sato Shintaro; Uematsu Satoshi; Yamamoto Masahiro; Takeuchi Osamu; Itagaki Sawako; Kumar Nirbhay; Horii Toshihiro; Akira Shizuo
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
The Journal of experimental medicine 2005;201(1):19-25.
2005: Akamine Morikazu; Higa Futoshi; Arakaki Noriko; Kawakami Kazuyoshi; Takeda Kiyoshi; Akira Shizuo; Saito Atsushi
Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila.
Infection and immunity 2005;73(1):352-61.
2005: Van Der Sluijs Koenraad F; Van Elden Leontine J R; Arens Ramon; Nijhuis Monique; Schuurman Rob; Florquin Sandrine; Kwakkel Joan; Akira Shizuo; Jansen Henk M; Lutter René; Van Der Polls Tom
Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus.
Immunology 2005;114(1):112-20.
2005: Takeda Kiyoshi; Akira Shizuo
Toll-like receptors in innate immunity.
International immunology 2005;17(1):1-14.
2005: Yukawa Kazunori; Kishino Masanori; Hoshino Katsuaki; Shirasawa Nobuyuki; Kimura Akihiko; Tsubota Yuji; Owada-Makabe Kyoko; Bai Tao; Tanaka Tetsuji; Ueyama Takashi; Ichinose Masakazu; Takeda Kiyoshi; Akira Shizuo; Maeda Masanobu
The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.
International journal of molecular medicine 2005;15(1):73-8.
2005: Buwitt-Beckmann Ute; Heine Holger; Wiesmüller Karl-Heinz; Jung Günther; Brock Roland; Akira Shizuo; Ulmer Artur J
Toll-like receptor 6-independent signaling by diacylated lipopeptides.
European journal of immunology 2005;35(1):282-9.
2005: Hemmi Hiroaki; Akira Shizuo
TLR signalling and the function of dendritic cells.
Chemical immunology and allergy 2005;86():120-35.
2005: Yamamoto Masahiro; Akira Shizuo
TIR domain-containing adaptors regulate TLR signaling pathways.
Advances in experimental medicine and biology 2005;560():1-9.
2005: Karaya Kazuhiro; Mori Seiichi; Kimoto Hisashi; Shima Yoko; Tsuji Yoshihito; Kurooka Hisanori; Akira Shizuo; Yokota Yoshifumi
Regulation of Id2 expression by CCAAT/enhancer binding protein beta.
Nucleic acids research 2005;33(6):1924-34.
2005: Kawai Taro; Akira Shizuo
Toll-like receptor downstream signaling.
Arthritis research & therapy 2005;7(1):12-9.
2004: Uematsu Satoshi; Akira Shizuo
[TLR family and viral infection]
Uirusu. Journal of virology 2004;54(2):145-51.
2004: Yamamoto Masahiro; Akira Shizuo
[TIR domain--containing adaptors regulate TLR-mediated signaling pathways]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(12):2197-203.
2004: Kaisho Tsuneyasu; Akira Shizuo
Pleiotropic function of Toll-like receptors.
Microbes and infection / Institut Pasteur 2004;6(15):1388-94.
2004: Stockinger Silvia; Reutterer Benjamin; Schaljo Barbara; Schellack Carola; Brunner Sylvia; Materna Tilo; Yamamoto Masahiro; Akira Shizuo; Taniguchi Tadatsugu; Murray Peter J; Müller Mathias; Decker Thomas
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7416-25.
2004: Suzuki Yoshinori; Wakita Daiko; Chamoto Kenji; Narita Yoshinori; Tsuji Takemasa; Takeshima Tsuguhide; Gyobu Hiroshi; Kawarada You; Kondo Satoshi; Akira Shizuo; Katoh Hiroyuki; Ikeda Hiroaki; Nishimura Takashi
Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity.
Cancer research 2004;64(23):8754-60.
2004: Knuefermann Pascal; Sakata Yasushi; Baker J Scott; Huang Chien-Hua; Sekiguchi Kenichi; Hardarson Hordur S; Takeuchi Osamu; Akira Shizuo; Vallejo Jesus G
Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart.
Circulation 2004;110(24):3693-8.
2004: Flo Trude H; Smith Kelly D; Sato Shintaro; Rodriguez David J; Holmes Margaret A; Strong Roland K; Akira Shizuo; Aderem Alan
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Nature 2004;432(7019):917-21.
2004: Chaisson Michelle L; Branstetter Daniel G; Derry Jonathan M; Armstrong Allison P; Tometsko Mark E; Takeda Kiyoshi; Akira Shizuo; Dougall William C
Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.
The Journal of biological chemistry 2004;279(52):54841-8.
2004: Wieland Catharina W; Knapp Sylvia; Florquin Sandrine; de Vos Alex F; Takeda Kiyoshi; Akira Shizuo; Golenbock Douglas T; Verbon Annelies; van der Poll Tom
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
American journal of respiratory and critical care medicine 2004;170(12):1367-74.
2004: Sumi K; Yokozeki H; Wu M-H; Satoh T; Kaneda Y; Takeda K; Akira S; Nishioka K
In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity.
Gene therapy 2004;11(24):1763-71.
2004: Yokozeki H; Wu M-H; Sumi K; Awad S; Satoh T; Katayama I; Takeda K; Akira S; Kaneda Y; Nishioka K
In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model.
Gene therapy 2004;11(24):1753-62.
2004: Takeuchi Osamu; Akira Shizuo
[Roles of Toll-like receptor in host defense and the mechanism of its signal transduction]
Nippon saikingaku zasshi. Japanese journal of bacteriology 2004;59(4):523-9.
2004: Hosoi Toru; Wada Sachiyo; Suzuki Sawako; Okuma Yasunobu; Akira Shizuo; Matsuda Tadashi; Nomura Yasuyuki
Bacterial endotoxin induces IL-20 expression in the glial cells.
Brain research. Molecular brain research 2004;130(1-2):23-9.
2004: Yamamoto Masatatsu; Yaginuma Katsuyuki; Tsutsui Hiroko; Sagara Junji; Guan Xin; Seki Ekihiro; Yasuda Koubun; Yamamoto Masahiro; Akira Shizuo; Nakanishi Kenji; Noda Tetsuo; Taniguchi Shun'ichiro
ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(11):1055-67.
2004: Oliveira Ana-Carolina; Peixoto Jaqueline R; de Arruda Luciana B; Campos Marco A; Gazzinelli Ricardo T; Golenbock Douglas T; Akira Shizuo; Previato José O; Mendonça-Previato Lúcia; Nobrega Alberto; Bellio Maria
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5688-96.
2004: Vossenkämper Anna; Struck Daniela; Alvarado-Esquivel Cosme; Went Tobias; Takeda Kioyshi; Akira Shizuo; Pfeffer Klaus; Alber Gottfried; Lochner Matthias; Förster Irmgard; Liesenfeld Oliver
Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control.
European journal of immunology 2004;34(11):3197-207.
2004: Hikoso Shungo; Yamaguchi Osamu; Higuchi Yoshiharu; Hirotani Shinichi; Takeda Toshihiro; Kashiwase Kazunori; Watanabe Tetsuya; Taniike Masayuki; Tsujimoto Ikuko; Asahi Michio; Matsumura Yasushi; Nishida Kazuhiko; Nakajima Hiroshi; Akira Shizuo; Hori Masatsugu; Otsu Kinya
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Circulation 2004;110(17):2631-7.
2004: Yang Rongcun; Murillo Francisco Martinez; Cui Hengmi; Blosser Richard; Uematsu Satoshi; Takeda Kiyoshi; Akira Shizuo; Viscidi Raphael P; Roden Richard B S
Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.
Journal of virology 2004;78(20):11152-60.
2004: Nakasone Chikara; Kawakami Kazuyoshi; Hoshino Tomoaki; Kawase Yusuke; Yokota Koichi; Yoshino Kohichiro; Takeda Kiyoshi; Akira Shizuo; Saito Atsushi
Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice.
Infection and immunity 2004;72(10):6176-80.
2004: tenOever Benjamin R; Sharma Sonia; Zou Wen; Sun Qiang; Grandvaux Nathalie; Julkunen Ilkka; Hemmi Hiroaki; Yamamoto M; Akira Shizuo; Yeh Wen-Chen; Lin Rongtuan; Hiscott John
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Journal of virology 2004;78(19):10636-49.
2004: Kawai Taro; Sato Shintaro; Ishii Ken J; Coban Cevayir; Hemmi Hiroaki; Yamamoto Masahiro; Terai Kenta; Matsuda Michiyuki; Inoue Jun-ichiro; Uematsu Satoshi; Takeuchi Osamu; Akira Shizuo
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nature immunology 2004;5(10):1061-8.
2004: Nicolle Delphine M; Pichon Xavier; Bouchot André; Maillet Isabelle; Erard François; Akira Shizuo; Ryffel Bernhard; Quesniaux Valérie F J
Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1305-21.
2004: Sato Nobuaki; Takahashi Naoyuki; Suda Koji; Nakamura Midori; Yamaki Mariko; Ninomiya Tadashi; Kobayashi Yasuhiro; Takada Haruhiko; Shibata Kenichiro; Yamamoto Masahiro; Takeda Kiyoshi; Akira Shizuo; Noguchi Toshihide; Udagawa Nobuyuki
MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.
The Journal of experimental medicine 2004;200(5):601-11.
2004: Takeji Masanobu; Kawada Noritaka; Moriyama Toshiki; Nagatoya Katsuyuki; Oseto Susumu; Akira Shizuo; Hori Masatsugu; Imai Enyu; Miwa Takeshi
CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression.
Journal of the American Society of Nephrology : JASN 2004;15(9):2383-90.
2004: Jang Sihyug; Uematsu Satoshi; Akira Shizuo; Salgame Padmini
IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3392-7.
2004: Smith Robert M; Suleman Naushaad; Lacerda Lydia; Opie Lionel H; Akira Shizuo; Chien Kenneth R; Sack Michael N
Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.
Cardiovascular research 2004;63(4):611-6.
2004: Nilsen Nadra; Nonstad Unni; Khan Naseema; Knetter Cathrine F; Akira Shizuo; Sundan Anders; Espevik Terje; Lien Egil
Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88.
The Journal of biological chemistry 2004;279(38):39727-35.
2004: Yang Rongcun; Murillo Francisco Martinez; Lin Ken-Yu; Yutzy William H; Uematsu Satoshi; Takeda Kiyoshi; Akira Shizuo; Viscidi Raphael P; Roden Richard B S
Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2624-31.
2004: Okamoto Masato; Furuichi Sachiko; Nishioka Yasuhiko; Oshikawa Tetsuya; Tano Tomoyuki; Ahmed Sharif Uddin; Takeda Kiyoshi; Akira Shizuo; Ryoma Yoshiki; Moriya Yoichiro; Saito Motoo; Sone Saburo; Sato Mitsunobu
Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation.
Cancer research 2004;64(15):5461-70.
2004: Bolz Devin D; Sundsbak Rhianna S; Ma Ying; Akira Shizuo; Kirschning Carsten J; Zachary James F; Weis John H; Weis Janis J
MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):2003-10.
2004: Kamei Daisuke; Yamakawa Kiyofumi; Takegoshi Yui; Mikami-Nakanishi Maya; Nakatani Yoshihito; Oh-Ishi Sachiko; Yasui Hidekazu; Azuma Yoshiaki; Hirasawa Noriyasu; Ohuchi Kazuo; Kawaguchi Hiroshi; Ishikawa Yukio; Ishii Toshiharu; Uematsu Satoshi; Akira Shizuo; Murakami Makoto; Kudo Ichiro
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.
The Journal of biological chemistry 2004;279(32):33684-95.
2004: Qiao Hong; Sonoda Koh-Hei; Sassa Yukio; Hisatomi Toshio; Yoshikawa Hiroshi; Ikeda Yasuhiro; Murata Toshinori; Akira Shizuo; Ishibashi Tatsuro
Abnormal retinal vascular development in IL-18 knockout mice.
Laboratory investigation; a journal of technical methods and pathology 2004;84(8):973-80.
2004: Krug Anne; French Anthony R; Barchet Winfried; Fischer Jens A A; Dzionek Andrzej; Pingel Jeanette T; Orihuela Michael M; Akira Shizuo; Yokoyama Wayne M; Colonna Marco
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.
Immunity 2004;21(1):107-19.
2004: Michelsen Kathrin S; Wong Michelle H; Shah Prediman K; Zhang Wenxuan; Yano Juliana; Doherty Terence M; Akira Shizuo; Rajavashisth Tripathi B; Arditi Moshe
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10679-84.
2004: Yamamoto Masahiro; Yamazaki Soh; Uematsu Satoshi; Sato Shintaro; Hemmi Hiroaki; Hoshino Katsuaki; Kaisho Tsuneyasu; Kuwata Hirotaka; Takeuchi Osamu; Takeshige Koichiro; Saitoh Tatsuya; Yamaoka Shoji; Yamamoto Naoki; Yamamoto Shunsuke; Muta Tatsushi; Takeda Kiyoshi; Akira Shizuo
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
Nature 2004;430(6996):218-22.
2004: Akira Shizuo; Takeda Kiyoshi
Toll-like receptor signalling.
Nature reviews. Immunology 2004;4(7):499-511.
2004: Kishino Masanori; Yukawa Kazunori; Hoshino Katsuaki; Kimura Akihiko; Shirasawa Nobuyuki; Otani Haruhisa; Tanaka Tetsuji; Owada-Makabe Kyoko; Tsubota Yuji; Maeda Masanobu; Ichinose Masakazu; Takeda Kiyoshi; Akira Shizuo; Mune Masatoshi
Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN 2004;15(7):1826-34.
2004: Yoneyama Mitsutoshi; Kikuchi Mika; Natsukawa Takashi; Shinobu Noriaki; Imaizumi Tadaatsu; Miyagishi Makoto; Taira Kazunari; Akira Shizuo; Fujita Takashi
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Nature immunology 2004;5(7):730-7.
2004: Gorogawa Shin-Ichi; Fujitani Yoshio; Kaneto Hideaki; Hazama Yoji; Watada Hirotaka; Miyamoto Yasuhide; Takeda Kiyoshi; Akira Shizuo; Magnuson Mark A; Yamasaki Yoshimitsu; Kajimoto Yoshitaka; Hori Masatsugu
Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
Biochemical and biophysical research communications 2004;319(4):1159-70.
2004: Akira Shizuo; Takeda Kiyoshi
Functions of toll-like receptors: lessons from KO mice.
Comptes rendus biologies 2004;327(6):581-9.
2004: Hemmi Hiroaki; Takeuchi Osamu; Sato Shintaro; Yamamoto Masahiro; Kaisho Tsuneyasu; Sanjo Hideki; Kawai Taro; Hoshino Katsuaki; Takeda Kiyoshi; Akira Shizuo
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
The Journal of experimental medicine 2004;199(12):1641-50.
2004: Ozawa Yoko; Nakao Keiko; Shimazaki Takuya; Takeda Junji; Akira Shizuo; Ishihara Katsuhiko; Hirano Toshio; Oguchi Yoshihisa; Okano Hideyuki
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Molecular and cellular neurosciences 2004;26(2):258-70.
2004: Boulé Melissa W; Broughton Courtney; Mackay Fabienne; Akira Shizuo; Marshak-Rothstein Ann; Rifkin Ian R
Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.
The Journal of experimental medicine 2004;199(12):1631-40.
2004: Mabuchi Tamaki; Kojima Hiroyuki; Abe Tetsuya; Takagi Kunio; Sakurai Madoka; Ohmiya Yoshihiro; Uematsu Satoshi; Akira Shizuo; Watanabe Kikuko; Ito Seiji
Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.
Neuroreport 2004;15(9):1395-8.
2004: Li Y; Ishii K; Hisaeda H; Hamano S; Zhang M; Nakanishi K; Yoshimoto T; Hemmi H; Takeda K; Akira S; Iwakura Y; Himeno K
IL-18 gene therapy develops Th1-type immune responses in Leishmania major-infected BALB/c mice: is the effect mediated by the CpG signaling TLR9?
Gene therapy 2004;11(11):941-8.
2004: Okamoto Masato; Oh-E Go; Oshikawa Tetsuya; Furuichi Sachiko; Tano Tomoyuki; Ahmed Sharif U; Akashi Sachiko; Miyake Kensuke; Takeuchi Osamu; Akira Shizuo; Himeno Kunisuke; Sato Mitsunobu; Ohkubo Shinya
Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant.
Clinical and diagnostic laboratory immunology 2004;11(3):483-95.
2004: Hosoi Toru; Suzuki Sawako; Nomura Jun; Ono Atsushi; Okuma Yasunobu; Akira Shizuo; Nomura Yasuyuki
Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells.
Brain research. Molecular brain research 2004;124(2):159-64.
2004: Mancuso Giuseppe; Midiri Angelina; Beninati Concetta; Biondo Carmelo; Galbo Roberta; Akira Shizuo; Henneke Philipp; Golenbock Douglas; Teti Giuseppe
Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6324-9.
2004: Sakai Akihiro; Han Jiahuai; Cato Andrew C B; Akira Shizuo; Li Jian-Dong
Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells.
BMC molecular biology 2004;5():2.
2004: Takeshita Keisuke; Yamasaki Tsugiko; Akira Shizuo; Gantner Florian; Bacon Kevin B
Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.
International immunology 2004;16(5):685-95.
2004: Pichyangkul Sathit; Yongvanitchit Kosol; Kum-arb Utaiwan; Hemmi Hiroaki; Akira Shizuo; Krieg Arthur M; Heppner D Gray; Stewart V Ann; Hasegawa Hitoshi; Looareesuwan Sornchai; Shanks G Dennis; Miller R Scott
Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4926-33.
2004: Dillon Stephanie; Agrawal Anshu; Van Dyke Thomas; Landreth Gary; McCauley Laurie; Koh Amy; Maliszewski Charles; Akira Shizuo; Pulendran Bali
A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(8):4733-43.
2004: Kawakami Kazuyoshi; Kinjo Yuki; Uezu Kaori; Miyagi Kazuya; Kinjo Takeshi; Yara Satomi; Koguchi Yoshinobu; Miyazato Akiko; Shibuya Kazutoshi; Iwakura Yoichiro; Takeda Kiyoshi; Akira Shizuo; Saito Atsushi
Interferon-gamma production and host protective response against Mycobacterium tuberculosis in mice lacking both IL-12p40 and IL-18.
Microbes and infection / Institut Pasteur 2004;6(4):339-49.
2004: Ikushima Hirofumi; Nishida Toshirou; Takeda Kiyoshi; Ito Toshinori; Yasuda Takushi; Yano Masahiko; Akira Shizuo; Matsuda Hikaru
Expression of Toll-like receptors 2 and 4 is downregulated after operation.
Surgery 2004;135(4):376-85.
2004: Torres David; Barrier Mathieu; Bihl Franck; Quesniaux Valerie J F; Maillet Isabelle; Akira Shizuo; Ryffel Bernhard; Erard François
Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
Infection and immunity 2004;72(4):2131-9.
2004: Weiss David S; Raupach Bärbel; Takeda Kiyoshi; Akira Shizuo; Zychlinsky Arturo
Toll-like receptors are temporally involved in host defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4463-9.
2004: Takeda Kiyoshi; Akira Shizuo
Microbial recognition by Toll-like receptors.
Journal of dermatological science 2004;34(2):73-82.
2004: Yukawa Kazunori; Hoshino Katsuaki; Kishino Masanori; Mune Masatoshi; Shirasawa Nobuyuki; Kimura Akihiko; Tsubota Yuji; Owada-Makabe Kyoko; Tanaka Tetsuji; Ichinose Masakazu; Maeda Masanobu; Takeda Kiyoshi; Akira Shizuo
Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.
International journal of molecular medicine 2004;13(4):515-20.
2004: Honstettre Amélie; Ghigo Eric; Moynault Alix; Capo Christian; Toman Rudolf; Akira Shizuo; Takeuchi Osamu; Lepidi Hubert; Raoult Didier; Mege Jean-Louis
Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3695-703.
2004: Robben Paul M; Mordue Dana G; Truscott Steven M; Takeda Kiyoshi; Akira Shizuo; Sibley L David
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3686-94.
2004: Knapp Sylvia; Wieland Catharina W; van 't Veer Cornelis; Takeuchi Osamu; Akira Shizuo; Florquin Sandrine; van der Poll Tom
Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3132-8.
2004: Heil Florian; Hemmi Hiroaki; Hochrein Hubertus; Ampenberger Franziska; Kirschning Carsten; Akira Shizuo; Lipford Grayson; Wagner Hermann; Bauer Stefan
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.
Science (New York, N.Y.) 2004;303(5663):1526-9.
2004: Diebold Sandra S; Kaisho Tsuneyasu; Hemmi Hiroaki; Akira Shizuo; Reis e Sousa Caetano
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Science (New York, N.Y.) 2004;303(5663):1529-31.
2004: Gomes M Salomé; Flórido Manuela; Cordeiro João V; Teixeira C Miguel; Takeuchi Osamu; Akira Shizuo; Appelberg Rui
Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium.
Immunology 2004;111(2):179-85.
2004: Shiratsuchi Akiko; Watanabe Ikuko; Takeuchi Osamu; Akira Shizuo; Nakanishi Yoshinobu
Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2039-47.
2004: Rachmilewitz Daniel; Katakura Kyoko; Karmeli Fanny; Hayashi Tomoko; Reinus Constantin; Rudensky Bernard; Akira Shizuo; Takeda Kiyoshi; Lee Jongdae; Takabayashi Kenji; Raz Eyal
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
Gastroenterology 2004;126(2):520-8.
2004: Zhao Hongmei; Hemmi Hiraoki; Akira Shizuo; Cheng Seng H; Scheule Ronald K; Yew Nelson S
Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):241-8.
2004: Takeda Kiyoshi; Akira Shizuo
TLR signaling pathways.
Seminars in immunology 2004;16(1):3-9.
2004: Heikenwalder Mathias; Polymenidou Magdalini; Junt Tobias; Sigurdson Christina; Wagner Hermann; Akira Shizuo; Zinkernagel Rolf; Aguzzi Adriano
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
Nature medicine 2004;10(2):187-92.
2004: Campos Marco A; Closel Meire; Valente Eneida P; Cardoso Jarbas E; Akira Shizuo; Alvarez-Leite Jacqueline I; Ropert Catherine; Gazzinelli Ricardo T
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1711-8.
2004: Inoue Hiroshi; Ogawa Wataru; Ozaki Michitaka; Haga Sanae; Matsumoto Michihiro; Furukawa Kensuke; Hashimoto Naoko; Kido Yoshiaki; Mori Toshiyuki; Sakaue Hiroshi; Teshigawara Kiyoshi; Jin Shiyu; Iguchi Haruhisa; Hiramatsu Ryuji; LeRoith Derek; Takeda Kiyoshi; Akira Shizuo; Kasuga Masato
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Nature medicine 2004;10(2):168-74.
2004: Into Takeshi; Kiura Kazuto; Yasuda Motoaki; Kataoka Hideo; Inoue Nobuo; Hasebe Akira; Takeda Kiyoshi; Akira Shizuo; Shibata Ken-ichiro
Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation.
Cellular microbiology 2004;6(2):187-99.
2004: Yamamoto Masahiro; Takeda Kiyoshi; Akira Shizuo
TIR domain-containing adaptors define the specificity of TLR signaling.
Molecular immunology 2004;40(12):861-8.
2004: Krug Anne; Luker Gary D; Barchet Winfried; Leib David A; Akira Shizuo; Colonna Marco
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.
Blood 2004;103(4):1433-7.
2004: Akazawa Takashi; Masuda Hisayo; Saeki Yoshiko; Matsumoto Misako; Takeda Kiyoshi; Tsujimura Kunio; Kuzushima Kiyotaka; Takahashi Toshitada; Azuma Ichiro; Akira Shizuo; Toyoshima Kumao; Seya Tsukasa
Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.
Cancer research 2004;64(2):757-64.
2004: Sasaki Hajime; Balto Khaled; Kawashima Nobuyuki; Eastcott Jean; Hoshino Katsuaki; Akira Shizuo; Stashenko Philip
Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo.
Clinical and diagnostic laboratory immunology 2004;11(1):106-10.
2004: Hokuto Isamu; Ikegami Machiko; Yoshida Mitsuhiro; Takeda Kiyoshi; Akira Shizuo; Perl Anne-Karina T; Hull William M; Wert Susan E; Whitsett Jeffrey A
Stat-3 is required for pulmonary homeostasis during hyperoxia.
The Journal of clinical investigation 2004;113(1):28-37.
2004: Wan Jun; Sun Luguo; Mendoza Jennifer Woo; Chui Yiu Loon; Huang Dolly P; Chen Zhijian J; Suzuki Nobutaka; Suzuki Shinobu; Yeh Wen-Chen; Akira Shizuo; Matsumoto Kunihiro; Liu Zheng-Gang; Wu Zhenguo
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.
Molecular and cellular biology 2004;24(1):192-9.
2004: Takeuchi Osamu; Hemmi Hiroaki; Akira Shizuo
Interferon response induced by Toll-like receptor signaling.
Journal of endotoxin research 2004;10(4):252-6.
2004: Marshak-Rothstein Ann; Busconi Liliana; Lau Christina M; Tabor Abigail S; Leadbetter Elizabeth A; Akira Shizuo; Krieg Arthur M; Lipford Grayson B; Viglianti Gregory A; Rifkin Ian R
Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells.
Journal of endotoxin research 2004;10(4):247-51.
2004: Kudo Masamichi; Aosai Fumie; Mun Hye-Seong; Norose Kazumi; Akira Shizuo; Iwakura Yoichiro; Yano Akihiko
The role of IFN-gamma and Toll-like receptors in nephropathy induced by Toxoplasma gondii infection.
Microbiology and immunology 2004;48(8):617-28.
2003: Kaisho Tsuneyasu; Akira Shizuo
Regulation of dendritic cell function through toll-like receptors.
Current molecular medicine 2003;3(8):759-71.
2003: Luftig Micah; Prinarakis Efthimios; Yasui Teruhito; Tsichritzis Theodore; Cahir-McFarland Ellen; Inoue Jun-Ichiro; Nakano Hiroyasu; Mak Tak Wah; Yeh Wen-Chen; Li Xiaoxia; Akira Shizuo; Suzuki Nobutaka; Suzuki Shinobu; Mosialos George; Kieff Elliott
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15595-600.
2003: Serbina Natalya V; Kuziel William; Flavell Richard; Akira Shizuo; Rollins Barrett; Pamer Eric G
Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Immunity 2003;19(6):891-901.
2003: Shishido Tetsuro; Nozaki Naoki; Yamaguchi Seiji; Shibata Yoko; Nitobe Joji; Miyamoto Takuya; Takahashi Hiroki; Arimoto Takanori; Maeda Kunihiko; Yamakawa Mitsunori; Takeuchi Osamu; Akira Shizuo; Takeishi Yasuchika; Kubota Isao
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction.
Circulation 2003;108(23):2905-10.
2003: Iiyama R; Kanai T; Uraushihara K; Ishikura T; Makita S; Totsuka T; Yamazaki M; Nakamura T; Miyata T; Yoshida H; Takeuchi O; Hoshino K; Takeda K; Ishikawa H; Akira S; Watanabe M
Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice.
Scandinavian journal of immunology 2003;58(6):620-7.
2003: Matsukawa Akihiro; Takeda Kiyoshi; Kudo Shinji; Maeda Takako; Kagayama Motoko; Akira Shizuo
Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6198-205.
2003: Joosten Leo A B; Koenders Marije I; Smeets Ruben L; Heuvelmans-Jacobs Marleen; Helsen Monique M A; Takeda Kiyoshi; Akira Shizuo; Lubberts Erik; van de Loo Fons A J; van den Berg Wim B
Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6145-53.
2003: Suzuki Nobutaka; Suzuki Shinobu; Eriksson Urs; Hara Hiromitsu; Mirtosis Christine; Chen Nien-Jung; Wada Teiji; Bouchard Denis; Hwang Irene; Takeda Kiyoshi; Fujita Takashi; Der Sandy; Penninger Josef M; Akira Shizuo; Saito Takashi; Yeh Wen-Chen
IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6065-71.
2003: Kuwata Hirotaka; Watanabe Yasuyuki; Miyoshi Hiroyuki; Yamamoto Masahiro; Kaisho Tsuneyasu; Takeda Kiyoshi; Akira Shizuo
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages.
Blood 2003;102(12):4123-9.
2003: Schirmbeck Reinhold; Riedl Petra; Zurbriggen Rinaldo; Akira Shizuo; Reimann Jörg
Antigenic epitopes fused to cationic peptide bound to oligonucleotides facilitate Toll-like receptor 9-dependent, but CD4+ T cell help-independent, priming of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5198-207.
2003: Heil Florian; Ahmad-Nejad Parviz; Hemmi Hiroaki; Hochrein Hubertus; Ampenberger Franziska; Gellert Tanja; Dietrich Harald; Lipford Grayson; Takeda Kiyoshi; Akira Shizuo; Wagner Hermann; Bauer Stefan
The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
European journal of immunology 2003;33(11):2987-97.
2003: Yamamoto Masahiro; Sato Shintaro; Hemmi Hiroaki; Uematsu Satoshi; Hoshino Katsuaki; Kaisho Tsuneyasu; Takeuchi Osamu; Takeda Kiyoshi; Akira Shizuo
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Nature immunology 2003;4(11):1144-50.
2003: Takahasi Kiyohiro; Suzuki Nobuo N; Horiuchi Masataka; Mori Mitsuaki; Suhara Wakako; Okabe Yasutaka; Fukuhara Yukiko; Terasawa Hiroaki; Akira Shizuo; Fujita Takashi; Inagaki Fuyuhiko
X-ray crystal structure of IRF-3 and its functional implications.
Nature structural biology 2003;10(11):922-7.
2003: Sato Shintaro; Sugiyama Masanaka; Yamamoto Masahiro; Watanabe Yasuyuki; Kawai Taro; Takeda Kiyoshi; Akira Shizuo
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4304-10.
2003: Haga Sanae; Terui Keita; Zhang Hui Qi; Enosawa Shin; Ogawa Wataru; Inoue Hiroshi; Okuyama Torayuki; Takeda Kiyoshi; Akira Shizuo; Ogino Tetsuya; Irani Kaikobad; Ozaki Michitaka
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.
The Journal of clinical investigation 2003;112(7):989-98.
2003: Shi Shuangping; Nathan Carl; Schnappinger Dirk; Drenkow Jörg; Fuortes Michele; Block Ellen; Ding Aihao; Gingeras Thomas R; Schoolnik Gary; Akira Shizuo; Takeda Kiyoshi; Ehrt Sabine
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
The Journal of experimental medicine 2003;198(7):987-97.
2003: Weijer Sebastiaan; Sewnath Miguel E; de Vos Alex F; Florquin Sandrine; van der Sluis Koen; Gouma Dirk J; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis.
Infection and immunity 2003;71(10):5488-97.
2003: Kariyone Ai; Tamura Toshiki; Kano Hideyuki; Iwakura Yoichiro; Takeda Kiyoshi; Akira Shizuo; Takatsu Kiyoshi
Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma.
International immunology 2003;15(10):1183-94.
2003: Akira Shizuo
Toll-like receptor signaling.
The Journal of biological chemistry 2003;278(40):38105-8.
2003: Cheng Fengdong; Wang Hong-Wei; Cuenca Alex; Huang Mei; Ghansah Tomar; Brayer Jason; Kerr William G; Takeda Kiyoshi; Akira Shizuo; Schoenberger Stephen P; Yu Hua; Jove Richard; Sotomayor Eduardo M
A critical role for Stat3 signaling in immune tolerance.
Immunity 2003;19(3):425-36.
2003: Honda Kenya; Sakaguchi Shinya; Nakajima Chigusa; Watanabe Ai; Yanai Hideyuki; Matsumoto Misako; Ohteki Toshiaki; Kaisho Tsuneyasu; Takaoka Akinori; Akira Shizuo; Seya Tsukasa; Taniguchi Tadatsugu
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10872-7.
2003: Shibue Tsukasa; Takeda Kiyoshi; Oda Eri; Tanaka Hiroshi; Murasawa Hideki; Takaoka Akinori; Morishita Yasuyuki; Akira Shizuo; Taniguchi Tadatsugu; Tanaka Nobuyuki
Integral role of Noxa in p53-mediated apoptotic response.
Genes & development 2003;17(18):2233-8.
2003: Marr Kieren A; Balajee S Arunmozhi; Hawn Thomas R; Ozinsky Adrian; Pham Uyenvy; Akira Shizuo; Aderem Alan; Liles W Conrad
Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens.
Infection and immunity 2003;71(9):5280-6.
2003: Kawai Taro; Akira Shizuo; Reed John C
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Molecular and cellular biology 2003;23(17):6174-86.
2003: Mun Hye-Seong; Aosai Fumie; Norose Kazumi; Chen Mei; Piao Lian-Xun; Takeuchi Osamu; Akira Shizuo; Ishikura Hiroshi; Yano Akihiko
TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection.
International immunology 2003;15(9):1081-7.
2003: Kaisho Tsuneyasu; Akira Shizuo
[Host defence mechanisms against infections: Innate immunity and adaptive immunity]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(8):1546-51.
2003: Takagi H; Kanai T; Okazawa A; Kishi Y; Sato T; Takaishi H; Inoue N; Ogata H; Iwao Y; Hoshino K; Takeda K; Akira S; Watanabe M; Ishii H; Hibi T
Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice.
Scandinavian journal of gastroenterology 2003;38(8):837-44.
2003: Ebisuno Yukihiko; Tanaka Toshiyuki; Kanemitsu Naotoshi; Kanda Hidenobu; Yamaguchi Kazuhito; Kaisho Tsuneyasu; Akira Shizuo; Miyasaka Masayuki
Cutting edge: the B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1642-6.
2003: Lund Jennifer; Sato Ayuko; Akira Shizuo; Medzhitov Ruslan; Iwasaki Akiko
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.
The Journal of experimental medicine 2003;198(3):513-20.
2003: Uehori Junji; Matsumoto Misako; Tsuji Shoutaro; Akazawa Takashi; Takeuchi Osamu; Akira Shizuo; Kawata Tsutomu; Azuma Ichiro; Toyoshima Kumao; Seya Tsukasa
Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan.
Infection and immunity 2003;71(8):4238-49.
2003: Yamamoto Masahiro; Sato Shintaro; Hemmi Hiroaki; Hoshino Katsuaki; Kaisho Tsuneyasu; Sanjo Hideki; Takeuchi Osamu; Sugiyama Masanaka; Okabe Masaru; Takeda Kiyoshi; Akira Shizuo
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Science (New York, N.Y.) 2003;301(5633):640-3.
2003: Kojima Eiji; Takeuchi Akihide; Haneda Masataka; Yagi Ayako; Hasegawa Tadao; Yamaki Ken-ichi; Takeda Kiyoshi; Akira Shizuo; Shimokata Kaoru; Isobe Ken-ichi
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1573-5.
2003: Yazawa Norihito; Fujimoto Manabu; Sato Shinichi; Miyake Kensuke; Asano Noriko; Nagai Yoshinori; Takeuchi Osamu; Takeda Kiyoshi; Okochi Hitoshi; Akira Shizuo; Tedder Thomas F; Tamaki Kunihiko
CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
Blood 2003;102(4):1374-80.
2003: Elhage Rima; Jawien Jacek; Rudling Mats; Ljunggren Hans-Gustaf; Takeda Kiyoshi; Akira Shizuo; Bayard Francis; Hansson Göran K
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice.
Cardiovascular research 2003;59(1):234-40.
2003: Jouault Thierry; Ibata-Ombetta Stella; Takeuchi Osamu; Trinel Pierre-André; Sacchetti Paola; Lefebvre Philippe; Akira Shizuo; Poulain Daniel
Candida albicans phospholipomannan is sensed through toll-like receptors.
The Journal of infectious diseases 2003;188(1):165-72.
2003: Liu Ningshu; Ohnishi Noriko; Ni Lin; Akira Shizuo; Bacon Kevin B
CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.
Nature immunology 2003;4(7):687-93.
2003: Akira Shizuo; Hoshino Katuaki
Myeloid differentiation factor 88-dependent and -independent pathways in toll-like receptor signaling.
The Journal of infectious diseases 2003;187 Suppl 2():S356-63.
2003: Yokozeki H; Wu M-H; Sumi K; Igawa K; Miyazaki Y; Katayama I; Takeda K; Akira S; Nishioka K
Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice.
Clinical and experimental immunology 2003;132(3):385-92.
2003: Kaisho Tsuneyasu; Akira Shizuo
Regulation of dendritic cell function through Toll-like receptors.
Current molecular medicine 2003;3(4):373-85.
2003: Akira S; Yamamoto M; Takeda K
Role of adapters in Toll-like receptor signalling.
Biochemical Society transactions 2003;31(Pt 3):637-42.
2003: Yasukawa Hideo; Ohishi Masanobu; Mori Hiroyuki; Murakami Masaaki; Chinen Takatoshi; Aki Daisuke; Hanada Toshikatsu; Takeda Kiyoshi; Akira Shizuo; Hoshijima Masahiko; Hirano Toshio; Chien Kenneth R; Yoshimura Akihiko
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Nature immunology 2003;4(6):551-6.
2003: Muraoka Osamu; Xu Bo; Tsurumaki Tatsuru; Akira Shizuo; Yamaguchi Tsuyoshi; Higuchi Hiroshi
Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines.
Neurochemistry international 2003;42(7):591-601.
2003: Goldstein Daniel R; Tesar Bethany M; Akira Shizuo; Lakkis Fadi G
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.
The Journal of clinical investigation 2003;111(10):1571-8.
2003: Zwijnenburg Petra J G; van der Poll Tom; Florquin Sandrine; Akira Shizuo; Takeda Kiyoshi; Roord John J; van Furth A Marceline
Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis.
Journal of neuroimmunology 2003;138(1-2):31-7.
2003: Kobayashi Masaya; Kweon Mi-Na; Kuwata Hirotaka; Schreiber Robert D; Kiyono Hiroshi; Takeda Kiyoshi; Akira Shizuo
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice.
The Journal of clinical investigation 2003;111(9):1297-308.
2003: Gantner Benjamin N; Simmons Randi M; Canavera Scott J; Akira Shizuo; Underhill David M
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.
The Journal of experimental medicine 2003;197(9):1107-17.
2003: Krutzik Stephan R; Ochoa Maria Teresa; Sieling Peter A; Uematsu Satoshi; Ng Yolanda W; Legaspi Annaliza; Liu Philip T; Cole Stewart T; Godowski Paul J; Maeda Yumi; Sarno Euzenir N; Norgard Michael V; Brennan Patrick J; Akira Shizuo; Rea Thomas H; Modlin Robert L
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
Nature medicine 2003;9(5):525-32.
2003: Datta Sandip K; Redecke Vanessa; Prilliman Kiley R; Takabayashi Kenji; Corr Maripat; Tallant Thomas; DiDonato Joseph; Dziarski Roman; Akira Shizuo; Schoenberger Stephen P; Raz Eyal
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4102-10.
2003: Edwards Alexander D; Diebold Sandra S; Slack Emma M C; Tomizawa Hideyuki; Hemmi Hiroaki; Kaisho Tsuneyasu; Akira Shizuo; Reis e Sousa Caetano
Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines.
European journal of immunology 2003;33(4):827-33.
2003: Schultz Marc J; Knapp Sylvia; Florquin Sandrine; Pater Jennie; Takeda Kiyoshi; Akira Shizuo; van der Poll Tom
Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa.
Infection and immunity 2003;71(4):1630-4.
2003: Hemmi Hiroaki; Kaisho Tsuneyasu; Takeda Kiyoshi; Akira Shizuo
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3059-64.
2003: Hazeki Kaoru; Masuda Naoyo; Funami Kenji; Sukenobu Naoe; Matsumoto Misako; Akira Shizuo; Takeda Kiyoshi; Seya Tsukasa; Hazeki Osamu
Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.
European journal of immunology 2003;33(3):740-7.
2003: Takeda Kiyoshi; Akira Shizuo
Toll receptors and pathogen resistance.
Cellular microbiology 2003;5(3):143-53.
2003: Prinz Marco; Heikenwalder Mathias; Schwarz Petra; Takeda Kiyoshi; Akira Shizuo; Aguzzi Adriano
Prion pathogenesis in the absence of Toll-like receptor signalling.
EMBO reports 2003;4(2):195-9.
2003: Okamoto Masato; Oshikawa Tetsuya; Tano Tomoyuki; Ohe Go; Furuichi Sachiko; Nishikawa Hidetomo; Ahmed Sharif Uddin; Akashi Sachiko; Miyake Kensuke; Takeuchi Osamu; Akira Shizuo; Moriya Yoichiro; Matsubara Shuzo; Ryoma Yoshiki; Saito Motoo; Sato Mitsunobu
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
Journal of the National Cancer Institute 2003;95(4):316-26.
2003: Sanjo Hideki; Takeda Kiyoshi; Tsujimura Tohru; Ninomiya-Tsuji Jun; Matsumoto Kunihiro; Akira Shizuo
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Molecular and cellular biology 2003;23(4):1231-8.
2003: Akira Shizuo
Mammalian Toll-like receptors.
Current opinion in immunology 2003;15(1):5-11.
2003: Akira Shizuo; Hemmi Hiroaki
Recognition of pathogen-associated molecular patterns by TLR family.
Immunology letters 2003;85(2):85-95.
2003: Girard Robert; Pedron Thierry; Uematsu Satoshi; Balloy Viviane; Chignard Michel; Akira Shizuo; Chaby Richard
Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2.
Journal of cell science 2003;116(Pt 2):293-302.
2003: Sugawara Isamu; Yamada Hiroyuki; Mizuno Satoru; Takeda Kiyoshi; Akira Shizuo
Mycobacterial infection in MyD88-deficient mice.
Microbiology and immunology 2003;47(11):841-7.
2003: Akira Shizuo; Sato Shintaro
Toll-like receptors and their signaling mechanisms.
Scandinavian journal of infectious diseases 2003;35(9):555-62.
2003: Tamai Riyoko; Sugawara Shunji; Takeuchi Osamu; Akira Shizuo; Takada Haruhiko
Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression.
Journal of endotoxin research 2003;9(3):145-53.
2003: Sugawara Isamu; Yamada Hiroyuki; Li Chuanyou; Mizuno Satoru; Takeuchi Osamu; Akira Shizuo
Mycobacterial infection in TLR2 and TLR6 knockout mice.
Microbiology and immunology 2003;47(5):327-36.
2003: Takeda Kiyoshi; Kaisho Tsuneyasu; Akira Shizuo
Toll-like receptors.
Annual review of immunology 2003;21():335-76.
2002: Takeda Kiyoshi; Akira Shizuo
[Role of toll-like receptor in innate immunity]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(16 Suppl):2097-102.
2002: Yamamoto Masahiro; Sato Shintaro; Mori Kiyotoshi; Hoshino Katsuaki; Takeuchi Osamu; Takeda Kiyoshi; Akira Shizuo
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6668-72.
2002: Morr Michael; Takeuchi Osamu; Akira Shizuo; Simon Markus M; Mühlradt Peter F
Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.
European journal of immunology 2002;32(12):3337-47.
2002: Imasato Akira; Desbois-Mouthon Christéle; Han Jiahuai; Kai Hirofumi; Cato Andrew C B; Akira Shizuo; Li Jian-Dong
Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2.
The Journal of biological chemistry 2002;277(49):47444-50.
2002: Yamamoto Masahiro; Sato Shintaro; Hemmi Hiroaki; Sanjo Hideki; Uematsu Satoshi; Kaisho Tsuneyasu; Hoshino Katsuaki; Takeuchi Osamu; Kobayashi Masaya; Fujita Takashi; Takeda Kiyoshi; Akira Shizuo
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature 2002;420(6913):324-9.
2002: Nakagawa Reiko; Naka Tetsuji; Tsutsui Hiroko; Fujimoto Minoru; Kimura Akihiro; Abe Tatsuo; Seki Ekihiro; Sato Shintaro; Takeuchi Osamu; Takeda Kiyoshi; Akira Shizuo; Yamanishi Koichi; Kawase Ichirou; Nakanishi Kenji; Kishimoto Tadamitsu
SOCS-1 participates in negative regulation of LPS responses.
Immunity 2002;17(5):677-87.
2002: Ogawa Tomohiko; Asai Yasuyuki; Hashimoto Masahito; Takeuchi Osamu; Kurita Tomoko; Yoshikai Yasunobu; Miyake Kensuke; Akira Shizuo
Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway.
International immunology 2002;14(11):1325-32.
2002: Aosai Fumie; Chen Mei; Kang Hyun-Kyu; Mun Hye-Seong; Norose Kazumi; Piao Lian Xun; Kobayashi Masashi; Takeuchi Osamu; Akira Shizuo; Yano Akihiko
Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen.
Cell stress & chaperones 2002;7(4):357-64.
2002: Chen M; Aosai F; Norose K; Mun H S; Takeuchi O; Akira S; Yano A
Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice.
The Journal of parasitology 2002;88(5):1017-9.
2002: Shimizu Hideyuki; Matsuguchi Tetsuya; Fukuda Yoshihide; Nakano Isao; Hayakawa Tetsuo; Takeuchi Osamu; Akira Shizuo; Umemura Masayuki; Suda Takashi; Yoshikai Yasunobu
Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.
Gastroenterology 2002;123(4):1265-77.
2002: Hoshino Katsuaki; Kaisho Tsuneyasu; Iwabe Tomio; Takeuchi Osamu; Akira Shizuo
Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.
International immunology 2002;14(10):1225-31.
2002: Henneke Philipp; Takeuchi Osamu; Malley Richard; Lien Egil; Ingalls Robin R; Freeman Mason W; Mayadas Tanya; Nizet Victor; Akira Shizuo; Kasper Dennis L; Golenbock Douglas T
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3970-7.
2002: Seki Ekihiro; Tsutsui Hiroko; Tsuji Noriko M; Hayashi Nobuki; Adachi Keishi; Nakano Hiroki; Futatsugi-Yumikura Shizue; Takeuchi Osamu; Hoshino Katsuaki; Akira Shizuo; Fujimoto Jiro; Nakanishi Kenji
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3863-8.
2002: Edwards Alexander D; Manickasingham Shivanthi P; Spörri Roman; Diebold Sandra S; Schulz Oliver; Sher Alan; Kaisho Tsuneyasu; Akira Shizuo; Reis e Sousa Caetano
Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3652-60.
2002: Yamao Takuji; Noguchi Tetsuya; Takeuchi Osamu; Nishiyama Uichi; Morita Haruhiko; Hagiwara Tetsuya; Akahori Hironori; Kato Takashi; Inagaki Kenjiro; Okazawa Hideki; Hayashi Yoshitake; Matozaki Takashi; Takeda Kiyoshi; Akira Shizuo; Kasuga Masato
Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.
The Journal of biological chemistry 2002;277(42):39833-9.
2002: Mallat Ziad; Silvestre Jean-Sébastien; Le Ricousse-Roussanne Sophie; Lecomte-Raclet Laurence; Corbaz Anne; Clergue Michel; Duriez Micheline; Barateau Véronique; Akira Shizuo; Tedgui Alain; Tobelem Gérard; Chvatchko Yolande; Lévy Bernard I
Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb.
Circulation research 2002;91(5):441-8.
2002: Flo Trude H; Ryan Liv; Latz Eicke; Takeuchi Osamu; Monks Brian G; Lien Egil; Halaas Øyvind; Akira Shizuo; Skjåk-Braek Gudmund; Golenbock Douglas T; Espevik Terje
Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
The Journal of biological chemistry 2002;277(38):35489-95.
2002: Tsuboi Naotake; Yoshikai Yasunobu; Matsuo Seiichi; Kikuchi Takeshi; Iwami Ken-Ichiro; Nagai Yoshiyuki; Takeuchi Osamu; Akira Shizuo; Matsuguchi Tetsuya
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2026-33.
2002: Konishi Hiroshi; Tsutsui Hiroko; Murakami Takaaki; Yumikura-Futatsugi Shizue; Yamanaka Kei-Ichi; Tanaka Minoru; Iwakura Yohichiro; Suzuki Noboru; Takeda Kiyoshi; Akira Shizuo; Nakanishi Kenji; Mizutani Hitoshi
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11340-5.
2002: Kim Jenny; Ochoa Maria-Teresa; Krutzik Stephan R; Takeuchi Osamu; Uematsu Satoshi; Legaspi Annaliza J; Brightbill Hans D; Holland Diana; Cunliffe William J; Akira Shizuo; Sieling Peter A; Godowski Paul J; Modlin Robert L
Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1535-41.
2002: Hawn Thomas R; Ozinsky Adrian; Underhill David M; Buckner Frederick S; Akira Shizuo; Aderem Alan
Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.
Microbes and infection / Institut Pasteur 2002;4(8):763-71.
2002: Takeuchi Osamu; Akira Shizuo
Genetic approaches to the study of Toll-like receptor function.
Microbes and infection / Institut Pasteur 2002;4(9):887-95.
2002: Wang Tianyi; Lafuse William P; Takeda Kiyoshi; Akira Shizuo; Zwilling Bruce S
Rapid chromatin remodeling of Toll-like receptor 2 promoter during infection of macrophages with Mycobacterium avium.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):795-801.
2002: Sato Shintaro; Takeuchi Osamu; Fujita Takashi; Tomizawa Hideyuki; Takeda Kiyoshi; Akira Shizuo
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.
International immunology 2002;14(7):783-91.
2002: Kaisho Tsuneyasu; Hoshino Katsuaki; Iwabe Tomio; Takeuchi Osamu; Yasui Teruhito; Akira Shizuo
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.
International immunology 2002;14(7):695-700.
2002: Suzuki Kotaro; Nakajima Hiroshi; Kagami Shin-Ichiro; Suto Akira; Ikeda Kei; Hirose Koichi; Hiwasa Takaki; Takeda Kiyoshi; Saito Yasushi; Akira Shizuo; Iwamoto Itsuo
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism.
The Journal of experimental medicine 2002;196(1):27-38.
2002: Kinjo Yuki; Kawakami Kazuyoshi; Uezu Kaori; Yara Satomi; Miyagi Kazuya; Koguchi Yoshinobu; Hoshino Tomoaki; Okamoto Masaki; Kawase Yusuke; Yokota Koichi; Yoshino Kohichiro; Takeda Kiyoshi; Akira Shizuo; Saito Atsushi
Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):323-9.
2002: Takeuchi Osamu; Sato Shintaro; Horiuchi Takao; Hoshino Katsuaki; Takeda Kiyoshi; Dong Zhongyun; Modlin Robert L; Akira Shizuo
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):10-4.
2002: Nagai Yoshinori; Akashi Sachiko; Nagafuku Masakazu; Ogata Masato; Iwakura Yoichiro; Akira Shizuo; Kitamura Toshio; Kosugi Atsushi; Kimoto Masao; Miyake Kensuke
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nature immunology 2002;3(7):667-72.
2002: Ito Tomoki; Amakawa Ryuichi; Kaisho Tsuneyasu; Hemmi Hiroaki; Tajima Kenichirou; Uehira Kazutaka; Ozaki Yoshio; Tomizawa Hideyuki; Akira Shizuo; Fukuhara Shirou
Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets.
The Journal of experimental medicine 2002;195(11):1507-12.
2002: Uematsu Satoshi; Matsumoto Makoto; Takeda Kiyoshi; Akira Shizuo
Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5811-6.
2002: Supajatura Volaluck; Ushio Hiroko; Nakao Atsuhito; Akira Shizuo; Okumura Ko; Ra Chisei; Ogawa Hideoki
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.
The Journal of clinical investigation 2002;109(10):1351-9.
2002: Coelho Patrícia S; Klein André; Talvani André; Coutinho Sibele F; Takeuchi Osamu; Akira Shizuo; Silva João S; Canizzaro Hélia; Gazzinelli Ricardo T; Teixeira Mauro M
Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages.
Journal of leukocyte biology 2002;71(5):837-44.
2002: Shuto Tsuyoshi; Imasato Akira; Jono Hirofumi; Sakai Akihiro; Xu Haidong; Watanabe Takahiro; Rixter Davida D; Kai Hirofumi; Andalibi Ali; Linthicum Fred; Guan Yue-Ling; Han Jiahuai; Cato Andrew C B; Lim David J; Akira Shizuo; Li Jian-Dong
Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase.
The Journal of biological chemistry 2002;277(19):17263-70.
2002: Akira Shizuo
[Innate immunity and allergic diseases]
Arerugi = [Allergy] 2002;51(4):352-6.
2002: Kimura-Shimmyo Akiko; Kashiwamura Shin-ichiro; Ueda Haruyasu; Ikeda Tomohiro; Kanno Sanae; Akira Shizuo; Nakanishi Kenji; Mimura Osamu; Okamura Haruki
Cytokine-induced injury of the lacrimal and salivary glands.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25 Suppl 1():S42-51.
2002: Yamazaki Tetsuo; Takeda Kiyoshi; Gotoh Kumiko; Takeshima Hiroshi; Akira Shizuo; Kurosaki Tomohiro
Essential immunoregulatory role for BCAP in B cell development and function.
The Journal of experimental medicine 2002;195(5):535-45.
2002: Tamai Riyoko; Sakuta Tetsuya; Matsushita Kenji; Torii Mitsuo; Takeuchi Osamu; Akira Shizuo; Akashi Sachiko; Espevik Terje; Sugawara Shunji; Takada Haruhiko
Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression.
Infection and immunity 2002;70(3):1272-8.
2002: Kaisho Tsuneyasu; Akira Shizuo
Toll-like receptors as adjuvant receptors.
Biochimica et biophysica acta 2002;1589(1):1-13.
2002: Oyadomari Seiichi; Koizumi Akio; Takeda Kiyoshi; Gotoh Tomomi; Akira Shizuo; Araki Eiichi; Mori Masataka
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.
The Journal of clinical investigation 2002;109(4):525-32.
2002: Okamoto Masaki; Kato Seiya; Oizumi Kotaro; Kinoshita Masaharu; Inoue Yoshimasa; Hoshino Katsuaki; Akira Shizuo; McKenzie Andrew N J; Young Howard A; Hoshino Tomoaki
Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia.
Blood 2002;99(4):1289-98.
2002: Hemmi Hiroaki; Kaisho Tsuneyasu; Takeuchi Osamu; Sato Shintaro; Sanjo Hideki; Hoshino Katsuaki; Horiuchi Takao; Tomizawa Hideyuki; Takeda Kiyoshi; Akira Shizuo
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nature immunology 2002;3(2):196-200.
2002: Schweizer Ulrich; Gunnersen Jennifer; Karch Christoph; Wiese Stefan; Holtmann Bettina; Takeda Kiyoshi; Akira Shizuo; Sendtner Michael
Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult.
The Journal of cell biology 2002;156(2):287-97.
2002: Lauw Fanny N; Branger Judith; Florquin Sandrine; Speelman Peter; van Deventer Sander J H; Akira Shizuo; van der Poll Tom
IL-18 improves the early antimicrobial host response to pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):372-8.
2002: Takeda Kiyoshi; Takeuchi Osamu; Akira Shizuo
Recognition of lipopeptides by Toll-like receptors.
Journal of endotoxin research 2002;8(6):459-63.
2002: Takeuchi O; Akira S
MyD88 as a bottle neck in Toll/IL-1 signaling.
Current topics in microbiology and immunology 2002;270():155-67.
2001: Takeda K; Akira S
Regulation of innate immune responses by Toll-like receptors.
Japanese journal of infectious diseases 2001;54(6):209-19.
2001: Henneke P; Takeuchi O; van Strijp J A; Guttormsen H K; Smith J A; Schromm A B; Espevik T A; Akira S; Nizet V; Kasper D L; Golenbock D T
Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7069-76.
2001: Nomi M; Oishi I; Kani S; Suzuki H; Matsuda T; Yoda A; Kitamura M; Itoh K; Takeuchi S; Takeda K; Akira S; Ikeya M; Takada S; Minami Y
Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.
Molecular and cellular biology 2001;21(24):8329-35.
2001: Kawai T; Takeuchi O; Fujita T; Inoue J; Mühlradt P F; Sato S; Hoshino K; Akira S
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5887-94.
2001: Kawakami K; Kinjo Y; Yara S; Uezu K; Koguchi Y; Tohyama M; Azuma M; Takeda K; Akira S; Saito A
Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis.
Infection and immunity 2001;69(11):6643-50.
2001: Kanai T; Watanabe M; Okazawa A; Sato T; Yamazaki M; Okamoto S; Ishii H; Totsuka T; Iiyama R; Okamoto R; Ikeda M; Kurimoto M; Takeda K; Akira S; Hibi T
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
Gastroenterology 2001;121(4):875-88.
2001: Kawashima T; Murata K; Akira S; Tonozuka Y; Minoshima Y; Feng S; Kumagai H; Tsuruga H; Ikeda Y; Asano S; Nosaka T; Kitamura T
STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3652-60.
2001: Schnare M; Barton G M; Holt A C; Takeda K; Akira S; Medzhitov R
Toll-like receptors control activation of adaptive immune responses.
Nature immunology 2001;2(10):947-50.
2001: Takeda K; Akira S
Roles of Toll-like receptors in innate immune responses.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(9):733-42.
2001: Oyadomari S; Takeda K; Takiguchi M; Gotoh T; Matsumoto M; Wada I; Akira S; Araki E; Mori M
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10845-50.
2001: Akira S
[Bacterial infections and toll-like receptors]
Kekkaku : [Tuberculosis] 2001;76(8):593-600.
2001: Akira S; Takeda K; Kaisho T
Toll-like receptors: critical proteins linking innate and acquired immunity.
Nature immunology 2001;2(8):675-80.
2001: Sugawara S; Yang S; Iki K; Hatakeyama J; Tamai R; Takeuchi O; Akashi S; Espevik T; Akira S; Takada H
Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2.
Infection and immunity 2001;69(8):4951-7.
2001: Bauer S; Kirschning C J; Häcker H; Redecke V; Hausmann S; Akira S; Wagner H; Lipford G B
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9237-42.
2001: Takeuchi O; Kawai T; Mühlradt P F; Morr M; Radolf J D; Zychlinsky A; Takeda K; Akira S
Discrimination of bacterial lipoproteins by Toll-like receptor 6.
International immunology 2001;13(7):933-40.
2001: Campos M A; Almeida I C; Takeuchi O; Akira S; Valente E P; Procópio D O; Travassos L R; Smith J A; Golenbock D T; Gazzinelli R T
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):416-23.
2001: Kaisho T; Akira S
Toll-like receptors and their signaling mechanism in innate immunity.
Acta odontologica Scandinavica 2001;59(3):124-30.
2001: Kaisho T; Takeuchi O; Kawai T; Hoshino K; Akira S
Endotoxin-induced maturation of MyD88-deficient dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5688-94.
2001: Takeuchi O; Akira S
Toll-like receptors; their physiological role and signal transduction system.
International immunopharmacology 2001;1(4):625-35.
2001: Hayashi F; Smith K D; Ozinsky A; Hawn T R; Yi E C; Goodlett D R; Eng J K; Akira S; Underhill D M; Aderem A
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
Nature 2001;410(6832):1099-103.
2001: Kimura T; Chowdhury S; Tanaka T; Shimizu A; Iwase K; Oyadomari S; Gotoh T; Matsuzaki H; Mori M; Akira S; Takiguchi M
CCAAT/enhancer-binding protein beta is required for activation of genes for ornithine cycle enzymes by glucocorticoids and glucagon in primary-cultured hepatocytes.
FEBS letters 2001;494(1-2):105-11.
2001: Yang S; Tamai R; Akashi S; Takeuchi O; Akira S; Sugawara S; Takada H
Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture.
Infection and immunity 2001;69(4):2045-53.
2001: Matsushima A; Kaisho T; Rennert P D; Nakano H; Kurosawa K; Uchida D; Takeda K; Akira S; Matsumoto M
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I.
The Journal of experimental medicine 2001;193(5):631-6.
2001: Kaisho T; Akira S
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.
Trends in immunology 2001;22(2):78-83.
2001: Thoma-Uszynski S; Stenger S; Takeuchi O; Ochoa M T; Engele M; Sieling P A; Barnes P F; Rollinghoff M; Bolcskei P L; Wagner M; Akira S; Norgard M V; Belisle J T; Godowski P J; Bloom B R; Modlin R L
Induction of direct antimicrobial activity through mammalian toll-like receptors.
Science (New York, N.Y.) 2001;291(5508):1544-7.
2001: Suzuki A; Hanada T; Mitsuyama K; Yoshida T; Kamizono S; Hoshino T; Kubo M; Yamashita A; Okabe M; Takeda K; Akira S; Matsumoto S; Toyonaga A; Sata M; Yoshimura A
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation.
The Journal of experimental medicine 2001;193(4):471-81.
2001: Kaisho T; Takeda K; Tsujimura T; Kawai T; Nomura F; Terada N; Akira S
IkappaB kinase alpha is essential for mature B cell development and function.
The Journal of experimental medicine 2001;193(4):417-26.
2001: Nishiguchi M; Matsumoto M; Takao T; Hoshino M; Shimonishi Y; Tsuji S; Begum N A; Takeuchi O; Akira S; Toyoshima K; Seya T
Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2610-6.
2001: Sugawara I; Mizuno S; Yamada H; Matsumoto M; Akira S
Disruption of nuclear factor-interleukin-6, a transcription factor, results in severe mycobacterial infection.
The American journal of pathology 2001;158(2):361-6.
2001: Kawazoe Y; Naka T; Fujimoto M; Kohzaki H; Morita Y; Narazaki M; Okumura K; Saitoh H; Nakagawa R; Uchiyama Y; Akira S; Kishimoto T
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
The Journal of experimental medicine 2001;193(2):263-9.
2001: Perera P Y; Mayadas T N; Takeuchi O; Akira S; Zaks-Zilberman M; Goyert S M; Vogel S N
CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):574-81.
2001: Takeda K; Akira S
Multi-functional roles of Stat3 revealed by conditional gene targeting.
Archivum immunologiae et therapiae experimentalis 2001;49(4):279-83.
2001: Akira S
Toll-like receptors and innate immunity.
Advances in immunology 2001;78():1-56.
2000: Akira S
[Signal pathways in immune systems: IL-1 R/Toll-like receptor family]
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):505-10.
2000: Hemmi H; Takeuchi O; Kawai T; Kaisho T; Sato S; Sanjo H; Matsumoto M; Hoshino K; Wagner H; Takeda K; Akira S
A Toll-like receptor recognizes bacterial DNA.
Nature 2000;408(6813):740-5.
2000: Sato S; Nomura F; Kawai T; Takeuchi O; Mühlradt P F; Takeda K; Akira S
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7096-101.
2000: Inagaki K; Yamao T; Noguchi T; Matozaki T; Fukunaga K; Takada T; Hosooka T; Akira S; Kasuga M
SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility.
The EMBO journal 2000;19(24):6721-31.
2000: Tsuji S; Matsumoto M; Takeuchi O; Akira S; Azuma I; Hayashi A; Toyoshima K; Seya T
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors.
Infection and immunity 2000;68(12):6883-90.
2000: Takeuchi O; Hoshino K; Akira S
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5392-6.
2000: Akira S
Toll-like receptors: lessons from knockout mice.
Biochemical Society transactions 2000;28(5):551-6.
2000: Schnare M; Holt A C; Takeda K; Akira S; Medzhitov R
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88.
Current biology : CB 2000;10(18):1139-42.
2000: Häcker H; Vabulas R M; Takeuchi O; Hoshino K; Akira S; Wagner H
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.
The Journal of experimental medicine 2000;192(4):595-600.
2000: Hashimoto A; Takeda K; Inaba M; Sekimata M; Kaisho T; Ikehara S; Homma Y; Akira S; Kurosaki T
Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1738-42.
2000: Lu H; Yang X; Takeda K; Zhang D; Fan Y; Luo M; Shen C; Wang S; Akira S; Brunham R C
Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity.
Molecular medicine (Cambridge, Mass.) 2000;6(7):604-12.
2000: Kawakami K; Koguchi Y; Qureshi M H; Miyazato A; Yara S; Kinjo Y; Iwakura Y; Takeda K; Akira S; Kurimoto M; Saito A
IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):941-7.
2000: Mokuno Y; Matsuguchi T; Takano M; Nishimura H; Washizu J; Ogawa T; Takeuchi O; Akira S; Nimura Y; Yoshikai Y
Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):931-40.
2000: Hashimoto M; Imamura Y; Morichika T; Arimoto K; Takeuchi O; Takeda K; Akira S; Aoyama K; Tamura T; Kotani S; Suda Y; Kusumoto S
Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation.
Biochemical and biophysical research communications 2000;273(1):164-9.
2000: Akira S
Roles of STAT3 defined by tissue-specific gene targeting.
Oncogene 2000;19(21):2607-11.
2000: Sansonetti P J; Phalipon A; Arondel J; Thirumalai K; Banerjee S; Akira S; Takeda K; Zychlinsky A
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation.
Immunity 2000;12(5):581-90.
2000: Kawakami K; Koguchi Y; Qureshi M H; Kinjo Y; Yara S; Miyazato A; Kurimoto M; Takeda K; Akira S; Saito A
Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice.
FEMS microbiology letters 2000;186(1):121-6.
2000: Nomura F; Akashi S; Sakao Y; Sato S; Kawai T; Matsumoto M; Nakanishi K; Kimoto M; Miyake K; Takeda K; Akira S
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3476-9.
2000: Nomura F; Kawai T; Nakanishi K; Akira S
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(3):191-202.
2000: Yokozeki H; Ghoreishi M; Takagawa S; Takayama K; Satoh T; Katayama I; Takeda K; Akira S; Nishioka K
Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity.
The Journal of experimental medicine 2000;191(6):995-1004.
2000: Kawakami K; Qureshi M H; Zhang T; Koguchi Y; Yara S; Takeda K; Akira S; Kurimoto M; Saito A
Involvement of endogenously synthesized interleukin (IL)-18 in the protective effects of IL-12 against pulmonary infection with Cryptococcus neoformans in mice.
FEMS immunology and medical microbiology 2000;27(3):191-200.
2000: Akira S
The role of IL-18 in innate immunity.
Current opinion in immunology 2000;12(1):59-63.
2000: Takeuchi S; Takeda K; Oishi I; Nomi M; Ikeya M; Itoh K; Tamura S; Ueda T; Hatta T; Otani H; Terashima T; Takada S; Yamamura H; Akira S; Minami Y
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(1):71-8.
2000: Takeuchi O; Kaufmann A; Grote K; Kawai T; Hoshino K; Morr M; Mühlradt P F; Akira S
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):554-7.
2000: Takeuchi O; Takeda K; Hoshino K; Adachi O; Ogawa T; Akira S
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
International immunology 2000;12(1):113-7.
2000: Akira S; Hoshino K; Kaisho T
The role of Toll-like receptors and MyD88 in innate immune responses.
Journal of endotoxin research 2000;6(5):383-7.
2000: Kaisho T; Akira S
Critical roles of Toll-like receptors in host defense.
Critical reviews in immunology 2000;20(5):393-405.
1999: Hoshino K; Kashiwamura S; Kuribayashi K; Kodama T; Tsujimura T; Nakanishi K; Matsuyama T; Takeda K; Akira S
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function.
The Journal of experimental medicine 1999;190(10):1541-8.
1999: Matsumoto M; Tanaka T; Kaisho T; Sanjo H; Copeland N G; Gilbert D J; Jenkins N A; Akira S
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):5039-48.
1999: Takeuchi O; Hoshino K; Kawai T; Sanjo H; Takada H; Ogawa T; Takeda K; Akira S
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity 1999;11(4):443-51.
1999: Sugawara I; Yamada H; Kaneko H; Mizuno S; Takeda K; Akira S
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice.
Infection and immunity 1999;67(5):2585-9.
1999: Matsui H; Ihara Y; Fujio Y; Kunisada K; Akira S; Kishimoto T; Yamauchi-Takihara K
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.
Cardiovascular research 1999;42(1):104-12.
1999: Mizoguchi C; Uehara S; Akira S; Takatsu K
IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2812-9.
1999: Oishi I; Takeuchi S; Hashimoto R; Nagabukuro A; Ueda T; Liu Z J; Hatta T; Akira S; Matsuda Y; Yamamura H; Otani H; Minami Y
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(1):41-56.
1997: Inoue M; Minami M; Matsumoto M; Kishimoto T; Akira S
The amino acid residues immediately carboxyl-terminal to the tyrosine phosphorylation site contribute to interleukin 6-specific activation of signal transducer and activator of transcription 3.
The Journal of biological chemistry 1997;272(14):9550-5.
1997: Kurebayashi S; Miyashita Y; Hirose T; Kasayama S; Akira S; Kishimoto T
Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor.
The Journal of steroid biochemistry and molecular biology 1997;60(1-2):11-7.

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