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Hermann Lage

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Adam Maciejczyk; Rafal Matkowski; Teresa Wysocka; Aleksandra Lacko; Marcin Ekiert; Balázs Györffy; Agnieszka Halon; Ewa Jagoda; Hermann Lage; Pawel Surowiak
Elevated nuclear S100P expression is associated with poor survival in early breast cancer patients.
Agnieszka Halon; Hermann Lage; Verena Materna; Rafal Matkowski; Jerzy Rabczynski; Piotr Donizy; Pawel Surowiak
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor.
Adam Maciejczyk; Rafal Matkowski; Marcin Ekiert; Hermann Lage; Jolanta Szelachowska; Agnieszka Halon; Pawel Surowiak
Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer.

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2013: Adam Maciejczyk; Rafal Matkowski; Teresa Wysocka; Aleksandra Lacko; Marcin Ekiert; Balázs Györffy; Agnieszka Halon; Ewa Jagoda; Hermann Lage; Pawel Surowiak
Elevated nuclear S100P expression is associated with poor survival in early breast cancer patients.
Histology and histopathology 2013;28(4):513-24.
2013: Agnieszka Halon; Hermann Lage; Verena Materna; Rafal Matkowski; Jerzy Rabczynski; Piotr Donizy; Pawel Surowiak
MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor.
Archives of gynecology and obstetrics 2013;287(3):563-70.
2012: Adam Maciejczyk; Rafal Matkowski; Marcin Ekiert; Hermann Lage; Jolanta Szelachowska; Agnieszka Halon; Pawel Surowiak
Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer.
Anticancer research 2012;32(8):3177-84.
2012: Agnieszka Halon; Marek Spaczynski; Maciej Zabel; Piotr Donizy; Tserenchunt Gansukh; Balázs Györffy; Hermann Lage; Adam Maciejczyk; Rafal Matkowski; Ewa Nowak-Markwitz; Pawel Surowiak
Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012;60(7):491-501.
2012: Adam Maciejczyk; Rafal Matkowski; Balázs Györffy; Ewa Jagoda; Hermann Lage; Teresa Wysocka; Pawel Surowiak
ABCC2 (MRP2, cMOAT) localized in the nuclear envelope of breast carcinoma cells correlates with poor clinical outcome.
Pathology oncology research : POR 2012;18(2):331-42.
2011: Adam Maciejczyk; Ewa Jagoda; Hermann Lage; Jolanta Szelachowska; Agata Szulc; Rafał Szulc; Bartłomiej Szynglarewicz; Teresa Wysocka; Pawel Surowiak
CD46 Expression is an unfavorable prognostic factor in breast cancer cases.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2011;19(6):540-6.
2011: Katarzyna Szczuraszek; Tomasz Wrobel; Piotr Donizy; Agnieszka Halon; Per Sonne Holm; Kazimierz Kuliczkowski; Hermann Lage; Verena Materna; Grzegorz Mazur; Pawel Surowiak
Elevated YB-1 expression is a new unfavorable prognostic factor in non-Hodgkin's lymphomas.
Anticancer research 2011;31(9):2963-70.
2011: Regina Holzmüller; Atsuko Kasajima; Hermann Lage; Klaus Mantwill; Emanuel Rognoni; Jürgen Schlegel; Tibor Schuster; Denise Treue; Wilko Weichert; Martina Anton; Bernd Gänsbacher; Cornelia Haczek; Per Sonne Holm
YB-1 dependent virotherapy in combination with temozolomide as a multimodal therapy approach to eradicate malignant glioma.
International journal of cancer. Journal international du cancer 2011;129(5):1265-76.
2011: Agnieszka Halon; Hermann Lage; Verena Materna; Ewa Nowak-Markwitz; Marek Spaczynski; Manfred Dietel; Piotr Donizy; Malgorzata Drag-Zalesinska; Tserenchunt Gansukh; Maciej Zabel; Pawel Surowiak
Estrogen receptor alpha expression in ovarian cancer predicts longer overall survival.
Pathology oncology research : POR 2011;17(3):511-8.
2011: Hermann Lage; Johannes H Fruehauf
Delivery of therapeutic RNA molecules to cancer cells by bacteria.
Therapeutic delivery 2011;2(4):441-9.
2011: Agnieszka Halon; Ewa Nowak-Markwitz; Adam Maciejczyk; Marek Pudelko; Tserenchunt Gansukh; Balázs Györffy; Piotr Donizy; Dawid Murawa; Rafal Matkowski; Marek Spaczynski; Hermann Lage; Pawel Surowiak
Loss of estrogen receptor beta expression correlates with shorter overall survival and lack of clinical response to chemotherapy in ovarian cancer patients.
Anticancer research 2011;31(2):711-8.
2010: Reka Kurucz; Elisa Belian; Denise Treue; Hermann Lage
Regulation of mRNA expression in drug-sensitive and drug-resistant gastric carcinoma cells is independent of YB-1 expression.
Anticancer research 2010;30(2):693-8.
2010: Elisa Belian; Reka Kurucz; Denise Treue; Hermann Lage
Effect of YB-1 on the regulation of micro RNA expression in drug-sensitive and drug-resistant gastric carcinoma cells.
Anticancer research 2010;30(2):629-33.
2010: Hermann Lage; Andrea Krühn
Bacterial delivery of RNAi effectors: transkingdom RNAi.
Journal of visualized experiments : JoVE 2010;(42):.
2010: Alexandra Stege; Andrea Krühn; Hermann Lage
Overcoming multidrug resistance by RNA interference.
Methods in molecular biology (Clifton, N.J.) 2010;596():447-65.
2009: Katarzyna Szczuraszek; Verena Materna; Agnieszka Halon; Grzegorz Mazur; Tomasz Wróbel; Kazimierz Kuliczkowski; Adam Maciejczyk; Maciej Zabel; Marcin Drag; Manfred Dietel; Hermann Lage; Pawel Surowiak
Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas.
Oncology reports 2009;22(6):1315-23.
2009: Andrea Krühn; Aijin Wang; Johannes H Fruehauf; Hermann Lage
Delivery of short hairpin RNAs by transkingdom RNA interference modulates the classical ABCB1-mediated multidrug-resistant phenotype of cancer cells.
Cell cycle (Georgetown, Tex.) 2009;8(20):3349-54.
2009: E Rognoni; M Widmaier; Cornelia Haczek; Klaus Mantwill; R Holzmüller; Bernd Gansbacher; Andreas Kolk; T Schuster; Roland M Schmid; Dieter Saur; Alexander Kaszubiak; Hermann Lage; Per Sonne Holm
Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo.
Cancer gene therapy 2009;16(10):753-63.
2009: Hermann Lage
Proteomic approaches for investigation of therapy resistance in cancer.
Proteomics. Clinical applications 2009;3(8):883-911.
2009: Pawel Surowiak; Marcin Drag; Verena Materna; Manfred Dietel; Hermann Lage
Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.
Molecular medicine reports 2009;2(4):543-8.
2009: Carsten Denkert; Jan Budczies; Silvia Darb-Esfahani; Balázs Györffy; Jalid Sehouli; Dominique Könsgen; Robert Zeillinger; Wilko Weichert; Aurelia Noske; Ann-Christin Buckendahl; Berit M Müller; Manfred Dietel; Hermann Lage
A prognostic gene expression index in ovarian cancer - validation across different independent data sets.
The Journal of pathology 2009;218(2):273-80.
2009: Areeg Faggad; Silvia Darb-Esfahani; Ralph Wirtz; Brigitte Sinn; Jalid Sehouli; Dominique Könsgen; Hermann Lage; Aurelia Noske; Wilko Weichert; Ann-Christin Buckendahl; Jan Budczies; Berit M Müller; Nasr E Elwali; Manfred Dietel; Carsten Denkert
Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis.
Histopathology 2009;54(6):657-66.
2009: Areeg Faggad; Silvia Darb-Esfahani; Ralph Wirtz; Brigitte Sinn; Jalid Sehouli; Dominique Könsgen; Hermann Lage; Wilko Weichert; Aurelia Noske; Jan Budczies; Berit M Müller; Ann-Christin Buckendahl; Annika Röske; Nasr Eldin Elwali; Manfred Dietel; Carsten Denkert
Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(4):579-88.
2009: Hermann Lage
Therapeutic potential of RNA interference in drug-resistant cancers.
Future oncology (London, England) 2009;5(2):169-85.
2009: Marcin Drag; Pawel Surowiak; Malgorzata Drag-Zalesinska; Manfred Dietel; Hermann Lage; Józef Oleksyszyn
Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.
Molecules (Basel, Switzerland) 2009;14(4):1639-51.
2008: Hermann Lage; Pawel Surowiak; Per Sonne Holm
[YB-1 as a potential target in cancer therapy].
Der Pathologe 2008;29 Suppl 2():187-90.
2008: Balázs Györffy; Manfred Dietel; Tibor Fekete; Hermann Lage
A snapshot of microarray-generated gene expression signatures associated with ovarian carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008;18(6):1215-33.
2008: Pawel Surowiak; Konrad Pawełczyk; Adam Maciejczyk; Marek Pudełko; Jerzy Kołodziej; Maciej Zabel; Dawid Murawa; Marcin Drag; Tserenchunt Gansukh; Manfred Dietel; Hermann Lage
Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer.
Anticancer research 2008;28(5B):2967-74.
2008: Pawel Surowiak; Verena Materna; Adam Maciejczyk; Marek Pudelko; Slawomir Suchocki; Witold Kedzia; Ewa Nowak-Markwitz; Malgorzata Dumanska; Marek Spaczynski; Maciej Zabel; Manfred Dietel; Hermann Lage
Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor.
Histology and histopathology 2008;23(5):531-8.
2008: Alexa Bieler; Klaus Mantwill; Regina Holzmüller; Karsten Jürchott; Alexander Kaszubiak; Sybille Stärk; Gabriel Glockzin; Hermann Lage; Anca L Grosu; Bernd Gansbacher; Per Sonne Holm
Impact of radiation therapy on the oncolytic adenovirus dl520: implications on the treatment of glioblastoma.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2008;86(3):419-27.
2008: Ulrike Stein; Wolfgang Walther; Alexandra Stege; Alexander Kaszubiak; Iduna Fichtner; Hermann Lage
Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):178-86.
2008: Katja Nelson; Victor Helmstaedter; Cynthia Moreau; Hermann Lage
Estradiol, tamoxifen and ICI 182,780 alter alpha3 and beta1 integrin expression and laminin-1 adhesion in oral squamous cell carcinoma cell cultures.
Oral oncology 2008;44(1):94-9.
2007: Christoph Röcken; Konrad Neumann; Stacy Carl-McGrath; Hermann Lage; Matthias P A Ebert; Jutta Dierkes; Christoph A Jacobi; Sinan Kalmuk; Peter Neuhaus; Ulf Neumann
The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients.
Neoplasia (New York, N.Y.) 2007;9(9):716-22.
2007: Guido Schumacher; Janine Hoffmann; Thorsten Cramer; Antonino Spinelli; Dietmar Jacob; Marcus Bahra; Johann Pratschke; Robert Pfitzmann; Sven Schmidt; Hermann Lage
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes.
Journal of gastroenterology and hepatology 2007;22(9):1469-73.
2007: Alexander Kaszubiak; Per Sonne Holm; Hermann Lage
Overcoming the classical multidrug resistance phenotype by adenoviral delivery of anti-MDR1 short hairpin RNAs and ribozymes.
International journal of oncology 2007;31(2):419-30.
2007: Katja Nelson; Victor Helmstaedter; Hermann Lage
The influence of tamoxifen on growth behavior and cell-cell adhesion in OSCC in vitro.
Oral oncology 2007;43(7):720-7.
2007: Pawel Surowiak; Dawid Murawa; Verena Materna; Adam Maciejczyk; Marek Pudelko; Slawomir Ciesla; Jan Breborowicz; Pawel Murawa; Maciej Zabel; Manfred Dietel; Hermann Lage
Occurence of stromal myofibroblasts in the invasive ductal breast cancer tissue is an unfavourable prognostic factor.
Anticancer research 2007;27(4C):2917-24.
2007: Pawel Surowiak; Adam Maciejczyk; Verena Materna; M Drag-Zalesińska; Andrzej Wojnar; Marek Pudelko; Witold Kedzia; M Spaczyński; Manfred Dietel; Maciej Zabel; Hermann Lage
Unfavourable prognostic significance of S100P expression in ovarian cancers.
Histopathology 2007;51(1):125-8.
2007: Alexander Kaszubiak; Annette Kupstat; Ursula Müller; Romy Hausmann; Per Sonne Holm; Hermann Lage
Regulation of MDR1 gene expression in multidrug-resistant cancer cells is independent from YB-1.
Biochemical and biophysical research communications 2007;357(1):295-301.
2007: Verena Materna; Pawel Surowiak; Ewa Markwitz; Marek Spaczynski; Malgorzata Drag-Zalesinska; Maciej Zabel; Hermann Lage
Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients.
Oncology reports 2007;17(3):505-16.
2007: Pawel Surowiak; Verena Materna; Adam Maciejczyk; Marek Pudełko; Ewa Markwitz; Marek Spaczyński; Manfred Dietel; Maciej Zabel; Hermann Lage
Nuclear metallothionein expression correlates with cisplatin resistance of ovarian cancer cells and poor clinical outcome.
Virchows Archiv : an international journal of pathology 2007;450(3):279-85.
2007: Aurelia Noske; Alexander Kaszubiak; Wilko Weichert; Christine Sers; Silvia Niesporek; Ines Koch; Birgit Schaefer; Jalid Sehouli; Manfred Dietel; Hermann Lage; Carsten Denkert
Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer.
Cancer letters 2007;246(1-2):190-200.
2007: Verena Materna; Pawel Surowiak; Irina Kaplenko; Merek Spaczyński; Zhenfeng Duan; Maciej Zabel; Manfred Dietel; Hermann Lage
Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients.
Virchows Archiv : an international journal of pathology 2007;450(2):187-94.
2007: Balázs Györffy; Hermann Lage
A Web-based data warehouse on gene expression in human malignant melanoma.
The Journal of investigative dermatology 2007;127(2):394-9.
2007: Hermann Lage; Carsten Denkert
Resistance to chemotherapy in ovarian carcinoma.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;176():51-60.
2006: Pawel Surowiak; Verena Materna; Irina Kaplenko; Marek Spaczynski; Barbara Dolinska-Krajewska; Elzbieta Gebarowska; Manfred Dietel; Maciej Zabel; Hermann Lage
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(23):7149-58.
2006: Pawel Surowiak; Verena Materna; Adam Maciejczyk; Irina Kaplenko; Marek Spaczynski; Manfred Dietel; Hermann Lage; Maciej Zabel
CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients.
Anticancer research 2006;26(6C):4943-8.
2006: Verena Materna; Alexandra Stege; Pawel Surowiak; Axel Priebsch; Hermann Lage
RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells.
Biochemical and biophysical research communications 2006;348(1):153-7.
2006: Pawel Surowiak; Marcin Drag; Verena Materna; Slawomir Suchocki; Renata Grzywa; M Spaczyński; Manfred Dietel; Józef Oleksyszyn; Maciej Zabel; Hermann Lage
Expression of aminopeptidase N/CD13 in human ovarian cancers.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(5):1783-8.
2006: Pawel Surowiak; Verena Materna; Balázs Györffy; Rafal Matkowski; Andrzej Wojnar; Adam Maciejczyk; Piotr Paluchowski; Piotr Dziegiel; M Pudełko; Jan Kornafel; Manfred Dietel; Glen Kristiansen; Maciej Zabel; Hermann Lage
Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers.
British journal of cancer 2006;95(3):339-46.
2006: Klaus Mantwill; Nadia Köhler-Vargas; Alexandra Bernshausen; Alexa Bieler; Hermann Lage; Alexander Kaszubiak; Pavel Surowiak; Tanja Dravits; Uwe Treiber; Rudolf Hartung; Bernd Gansbacher; Per Sonne Holm
Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with chemotherapeutic agents.
Cancer research 2006;66(14):7195-202.
2006: Hermann Lage
MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance.
Current drug targets 2006;7(7):813-21.
2006: Pawel Surowiak; Verena Materna; Irina Kaplenko; Marek Spaczynski; Manfred Dietel; Hermann Lage; Maciej Zabel
Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples.
Histology and histopathology 2006;21(7):713-20.
2006: Hermann Lage; Esin Aki-Sener; Ismail Yalcin
High antineoplastic activity of new heterocyclic compounds in cancer cells with resistance against classical DNA topoisomerase II-targeting drugs.
International journal of cancer. Journal international du cancer 2006;119(1):213-20.
2006: Pawel Surowiak; Verena Materna; Carsten Denkert; Irina Kaplenko; Marek Spaczyński; Manfred Dietel; Maciej Zabel; Hermann Lage
Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers.
Cancer letters 2006;235(2):272-80.
2006: Pawel Surowiak; Verena Materna; Malgorzata Drag-Zalesinska; Andrzej Wojnar; Irina Kaplenko; Marek Spaczyński; Manfred Dietel; Maciej Zabel; Hermann Lage
Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2006;25(2):131-9.
2006: Balázs Györffy; Violeta Serra; Verena Materna; Reinhold Schäfer; Manfred Dietel; Dirk Schadendorf; Hermann Lage
Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs.
Melanoma research 2006;16(2):147-55.
2006: Balázs Györffy; Pawel Surowiak; Olaf Kiesslich; Carsten Denkert; Reinhold Schäfer; Manfred Dietel; Hermann Lage
Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations.
International journal of cancer. Journal international du cancer 2006;118(7):1699-712.
2006: Pawel Surowiak; Verena Materna; Irina Kaplenko; M Spaczyński; Manfred Dietel; Glen Kristiansen; Hermann Lage; Maciej Zabel
Unfavorable prognostic value of CD24 expression in sections from primary and relapsed ovarian cancer tissue.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(2):515-21.
2006: Axel Priebsch; Franziska Rompe; Holger Tönnies; Petra Kowalski; Pawel Surowiak; Alexandra Stege; Verena Materna; Hermann Lage
Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells.
Oligonucleotides 2006;16(3):263-74.
2006: Pawel Surowiak; Verena Materna; Piotr Paluchowski; Rafal Matkowski; Andrzej Wojnar; Adam Maciejczyk; Marek Pudelko; Jan Kornafel; Manfred Dietel; Glen Kristiansen; Hermann Lage; Maciej Zabel
CD24 expression is specific for tamoxifen-resistant ductal breast cancer cases.
Anticancer research 2006;26(1B):629-34.
2006: Alexa Bieler; Klaus Mantwill; Tanja Dravits; Alexandra Bernshausen; Gabriel Glockzin; Nadia Köhler-Vargas; Hermann Lage; Bernd Gansbacher; Per Sonne Holm
Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520.
Human gene therapy 2006;17(1):55-70.
2005: Balázs Györffy; Violeta Serra; Karsten Jürchott; rula abdul ghani; Mitch Garber; Ulrike Stein; Iver Petersen; Hermann Lage; Manfred Dietel; Reinhold Schäfer
Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival.
Oncogene 2005;24(51):7542-51.
2005: Pawel Surowiak; Verena Materna; Irina Kaplenko; Marek Spaczyński; Manfred Dietel; Hermann Lage; Maciej Zabel
Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients.
Virchows Archiv : an international journal of pathology 2005;447(3):626-33.
2005: Verena Materna; Bernd Liedert; Jürgen Thomale; Hermann Lage
Protection of platinum-DNA adduct formation and reversal of cisplatin resistance by anti-MRP2 hammerhead ribozymes in human cancer cells.
International journal of cancer. Journal international du cancer 2005;115(3):393-402.
2005: Christiane Nieth; Hermann Lage
Induction of the ABC-transporters Mdr1/P-gp (Abcb1), mrpl (Abcc1), and bcrp (Abcg2) during establishment of multidrug resistance following exposure to mitoxantrone.
Journal of chemotherapy (Florence, Italy) 2005;17(2):215-23.
2005: Petra Kowalski; Pawel Surowiak; Hermann Lage
Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC transporters MDR1/P-gp, MRP2, and BCRP.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(4):508-22.
2005: Hermann Lage
Potential applications of RNA interference technology in the treatment of cancer.
Future oncology (London, England) 2005;1(1):103-13.
2005: Pawel Surowiak; Verena Materna; Rafal Matkowski; Katarzyna Szczuraszek; Jan Kornafel; Andrzej Wojnar; Marek Pudelko; Manfred Dietel; Carsten Denkert; Maciej Zabel; Hermann Lage
Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance.
Breast cancer research : BCR 2005;7(5):R862-70.
2005: Pawel Surowiak; Verena Materna; Katarzyna Kłak; Marek Spaczyński; Manfred Dietel; Glen Kristiansen; Hermann Lage; Maciej Zabel
Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients.
Polish journal of pathology : official journal of the Polish Society of Pathologists 2005;56(2):69-74.
2004: Alexandra Stege; Axel Priebsch; Christiane Nieth; Hermann Lage
Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference.
Cancer gene therapy 2004;11(11):699-706.
2004: Holger Tönnies; Hermann Lage
Chromosomal imbalances associated with drug resistance and thermoresistance in human pancreatic carcinoma cells.
European journal of cell biology 2004;83(10):591-601.
2004: Verena Materna; Juliane Pleger; Uwe Hoffmann; Hermann Lage
RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: correlation with chemotherapeutic response.
Gynecologic oncology 2004;94(1):152-60.
2004: Anke Wichert; Alexandra Stege; Yutaka Midorikawa; Per Sonne Holm; Hermann Lage
Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells.
Oncogene 2004;23(4):945-55.
2004: Hermann Lage
Proteomics in cancer cell research: an analysis of therapy resistance.
Pathology, research and practice 2004;200(2):105-17.
2004: Julia Poland; Andrea Urbani; Hermann Lage; Martina Schnölzer; Pranav Sinha
Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis.
Electrophoresis 2004;25(1):173-83.
2004: Per Sonne Holm; Hermann Lage; Stephan Bergmann; Karsten Jürchott; Gabriel Glockzin; Alexandra Bernshausen; Klaus Mantwill; Axel Ladhoff; Anke Wichert; Joe S Mymryk; Thomas Ritter; Manfred Dietel; Bernd Gänsbacher; hans-dieter royer
Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy.
Cancer research 2004;64(1):322-8.
2003: Holger Woehlecke; Hiroyuki Osada; Andreas Herrmann; Hermann Lage
Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A.
International journal of cancer. Journal international du cancer 2003;107(5):721-8.
2003: Holger Woehlecke; Antje Pohl; Nele Alder-Baerens; Hermann Lage; Andreas Herrmann
Enhanced exposure of phosphatidylserine in human gastric carcinoma cells overexpressing the half-size ABC transporter BCRP (ABCG2).
The Biochemical journal 2003;376(Pt 2):489-95.
2003: Pranav Sinha; Julia Poland; Sandro Kohl; Martina Schnölzer; Heike Helmbach; Gero Hütter; Hermann Lage; Dirk Schadendorf
Study of the development of chemoresistance in melanoma cell lines using proteome analysis.
Electrophoresis 2003;24(14):2386-404.
2003: Bernd Liedert; Verena Materna; Dirk Schadendorf; Jürgen Thomale; Hermann Lage
Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin.
The Journal of investigative dermatology 2003;121(1):172-6.
2003: Christiane Nieth; Axel Priebsch; Alexandra Stege; Hermann Lage
Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).
FEBS letters 2003;545(2-3):144-50.
2003: Holger Tönnies; Julia Poland; Pranav Sinha; Hermann Lage
Association of genomic imbalances with drug resistance and thermoresistance in human gastric carcinoma cells.
International journal of cancer. Journal international du cancer 2003;103(6):752-8.
2003: Hermann Lage
Molecular analysis of therapy resistance in gastric cancer.
Digestive diseases (Basel, Switzerland) 2003;21(4):326-38.
2003: Verena Materna; Hermann Lage
Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patient.
Journal of human genetics 2003;48(9):484-6.
2002: Antje Ludwig; Manfred Dietel; Hermann Lage
Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells.
Anticancer research 2002;22(6A):3213-21.
2002: Hermann Lage; Manfred Dietel
Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells.
Journal of cancer research and clinical oncology 2002;128(7):349-57.
2002: Petra Kowalski; Ulrike Stein; George L Scheffer; Hermann Lage
Modulation of the atypical multidrug-resistant phenotype by a hammerhead ribozyme directed against the ABC transporter BCRP/MXR/ABCG2.
Cancer gene therapy 2002;9(7):579-86.
2002: Antje Pohl; Hermann Lage; Peter Müller; Thomas Pomorski; Andreas Herrmann
Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line.
The Biochemical journal 2002;365(Pt 1):259-68.
2002: Per Sonne Holm; Stephan Bergmann; Karsten Jurchott; Hermann Lage; Karsten Brand; Axel Ladhoff; Klaus Mantwill; David T Curiel; Matthias Dobbelstein; Manfred Dietel; Bernd Gansbacher; hans-dieter royer
YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.
The Journal of biological chemistry 2002;277(12):10427-34.
2002: Julia Poland; Dirk Schadendorf; Hermann Lage; Martina Schnölzer; Julio E Celis; Pranav Sinha
Study of therapy resistance in cancer cells with functional proteome analysis.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(3):221-34.
2002: Ulrike Stein; Hermann Lage; Andreas Jordan; Wolfgang Walther; Susan E Bates; Thomas Litman; Peter Hohenberger; Manfred Dietel
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.
International journal of cancer. Journal international du cancer 2002;97(6):751-60.
2001: Hermann Lage; C Perlitz; Rupert Abele; Robert Tampé; Manfred Dietel; Dirk Schadendorf; P Sinha
Enhanced expression of human ABC-transporter tap is associated with cellular resistance to mitoxantrone.
FEBS letters 2001;503(2-3):179-84.
2001: Pranav Sinha; Julia Poland; Martina Schnölzer; J E Celis; Hermann Lage
Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines.
Electrophoresis 2001;22(14):2990-3000.
2001: Hermann Lage; U Kellner; Andrea Tannapfel; Manfred Dietel
Expression of a glypican-related 62-kDa antigen is decreased in hepatocellular carcinoma in correspondence to the grade of tumor differentiation.
Virchows Archiv : an international journal of pathology 2001;438(6):567-73.
2001: Hermann Lage; Heike Helmbach; C Grottke; Manfred Dietel; Dirk Schadendorf
DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells.
FEBS letters 2001;494(1-2):54-9.
2001: Markus Christmann; M Pick; Hermann Lage; Dirk Schadendorf; Bernd Kaina
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
International journal of cancer. Journal international du cancer 2001;92(1):123-9.
2001: Petra Kowalski; Anke Wichert; Per Sonne Holm; Manfred Dietel; Hermann Lage
Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2.
Cancer gene therapy 2001;8(3):185-92.
2001: Verena Materna; Per Sonne Holm; Manfred Dietel; Hermann Lage
Kinetic characterization of ribozymes directed against the cisplatin resistance-associated ABC transporter cMOAT/MRP2/ABCC2.
Cancer gene therapy 2001;8(3):176-84.
2000: C Grottke; Klaus Mantwill; Manfred Dietel; Dirk Schadendorf; Hermann Lage
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
International journal of cancer. Journal international du cancer 2000;88(4):535-46.
2000: Pranav Sinha; S Kohl; J Fischer; Gero Hütter; M Kern; Eckart Köttgen; Manfred Dietel; Hermann Lage; Martina Schnölzer; Dirk Schadendorf
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Electrophoresis 2000;21(14):3048-57.
2000: Hermann Lage; A Jordan; R Scholz; Manfred Dietel
Thermosensitivity of multidrug-resistant human gastric and pancreatic carcinoma cells.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2000;16(4):291-303.
2000: Hermann Lage; Heike Helmbach; Manfred Dietel; Dirk Schadendorf
Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance.
British journal of cancer 2000;82(2):488-91.
1999: Pranav Sinha; Gero Hütter; Eckart Köttgen; Manfred Dietel; Dirk Schadendorf; Hermann Lage
Search for novel proteins involved in the development of chemoresistance in colorectal cancer and fibrosarcoma cells in vitro using two-dimensional electrophoresis, mass spectrometry and microsequencing.
Electrophoresis 1999;20(14):2961-9.
1999: Pranav Sinha; Gero Hütter; Eckart Köttgen; Manfred Dietel; Dirk Schadendorf; Hermann Lage
Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas.
Electrophoresis 1999;20(14):2952-60.
1999: Anke Wichert; Per Sonne Holm; Manfred Dietel; Hermann Lage
Selection of a high activity ribozyme against cytostatic drug resistance-associated glypican-3 using an in vitro assay containing total tumor RNA.
Cancer gene therapy 1999;6(3):263-70.
1999: Hermann Lage; Markus Christmann; M A Kern; Manfred Dietel; M Pick; Bernd Kaina; Dirk Schadendorf
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance.
International journal of cancer. Journal international du cancer 1999;80(5):744-50.
1998: Pranav Sinha; Gero Hütter; Eckart Köttgen; Manfred Dietel; Dirk Schadendorf; Hermann Lage
Increased expression of annexin I and thioredoxin detected by two-dimensional gel electrophoresis of drug resistant human stomach cancer cells.
Journal of biochemical and biophysical methods 1998;37(3):105-16.
1998: A Schwendel; F Richard; Holger Langreck; O Kaufmann; Hermann Lage; Klaus-Jürgen Winzer; Iver Petersen; Manfred Dietel
Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.
British journal of cancer 1998;78(6):806-11.
1997: Hermann Lage; Manfred Dietel
Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5.
Gene 1997;188(2):151-6.
1996: Hermann Lage; Manfred Dietel
Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase.
Gene 1996;178(1-2):187-9.