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Thomas Seufferlein

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TOP 3
Thomas Seufferlein
Systemic treatment of advanced pancreatic cancer--step by step progress.
Giorgio Fois; Franz Oswald; Thomas Seufferlein; Goetz von Wichert; Michael Weimer; Tobias Busch; Paul Dietl; Erika T Felder; Edward Felder
Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells.
S Parmar; T Paul; S Rüdiger; C Schumann; A Seeringer; Thomas Seufferlein; S Boeck; V Heinemann; Volker Kächele; J C Stingl
Pharmacogenetic predictors for EGFR-inhibitor-associated skin toxicity.

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All Publications

2013: Thomas Seufferlein
Systemic treatment of advanced pancreatic cancer--step by step progress.
Gut 2013;62(5):660-1.
2013: Giorgio Fois; Franz Oswald; Thomas Seufferlein; Goetz von Wichert; Michael Weimer; Tobias Busch; Paul Dietl; Erika T Felder; Edward Felder
Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1322-9.
2013: S Parmar; T Paul; S Rüdiger; C Schumann; A Seeringer; Thomas Seufferlein; S Boeck; V Heinemann; Volker Kächele; J C Stingl
Pharmacogenetic predictors for EGFR-inhibitor-associated skin toxicity.
The pharmacogenomics journal 2013;13(2):181-8.
2013: Stefan Liebau; Pallavi U Mahaddalkar; Thomas Seufferlein; Anett Illing; Hans A Kestler; Alexander Kleger
A hierarchy in reprogramming capacity in different tissue microenvironments: what we know and what we need to know.
Stem cells and development 2013;22(5):695-706.
2013: Alexander Kleger; Jacqueline Schnell; Thomas Seufferlein; Martin Wagner; Martin Bommer; Andreas Essig; Georg Härter
Fecal transplant in refractory Clostridium difficile colitis.
Deutsches Ärzteblatt international 2013;110(7):108-15.
2013: Gabriele Fluhr; Anne Glitsch; Thomas Gress; Péter Hegyi; Albrecht Hoffmeister; Marcus Kantowski; Thomas Kohlmann; Matthias Kraft; Ali Aghdassi; Petra Büchner-Steudel; Christoph Budde; László Czakó; Georg Engel; Thomas Linhart; Jochen Maul; Julia Mayerle; Joachim Mössner; Martina Müller; Claudia Nitsche; Tilman Pickartz; Thomas Rösch; Jonas Rosendahl; Thomas Seufferlein; Britta Siegmund; Peter Simon; Andreas Stallmach; Kirsten Storck; Eckhard Weber; Ina Zuber-Jerger; Markus M Lerch
Pre-Study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.
BMC gastroenterology 2013;13():11.
2012: Daniel Fuerst; Volker Heinemann; Volker Kaechele; Joannis Mytilineos; Sumit Parmar; Tanusree Paul; Stefan Rüdiger; Christian Schumann; Thomas Seufferlein; Kristina Stiebel; Stefan Boeck; Julia Carolin Stingl
HLA polymorphisms influence the development of skin rash arising from treatment with EGF receptor inhibitors.
Pharmacogenomics 2012;13(13):1469-76.
2012: Alexander Zipprich; Wolfgang E Fleig; Guadalupe Garcia-Tsao; Sebastian Rogowski; Thomas Seufferlein; Matthias M Dollinger
Prognostic indicators of survival in patients with compensated and decompensated cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(9):1407-14.
2012: Tim Eiseler; Nancy Funk; Arsia Jamali; Golsa Joodi; Conny Köhler; Subbaiah Chary Nimmagadda; Peter Storz; Thomas Seufferlein
Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1.
The Journal of biological chemistry 2012;287(39):32367-80.
2012: Alexander Zipprich; Thomas Seufferlein; M M Dollinger
Subclinical ascites defines an intermediate stage between compensated and decompensated cirrhosis.
Zeitschrift für Gastroenterologie 2012;50(9):996-1001.
2012: Denis Krndija; Ulrike Maass; Christin Münzberg; Franz Oswald; Thomas Seufferlein; Guido Adler; Margit Hafner; Hans A Kestler; Goetz von Wichert
The phosphatase of regenerating liver 3 (PRL-3) promotes cell migration through Arf-activity-dependent stimulation of integrin α5 recycling.
Journal of cell science 2012;125(Pt 16):3883-92.
2012: Tobias Busch; Tim Eiseler; Julia Jansen; Golsa Joodi; M Bishr Omary; Joachim P Spatz; Claudia Temme; Goetz von Wichert; Milena Armacki; Thomas Seufferlein
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
Journal of cell science 2012;125(Pt 9):2148-59.
2012: C Lübbert; S Behl; T J Ettrich; D Wilhelms; Dieter Worlitzsch; Thomas Seufferlein
[Antibiotic treatment of enterococcal infections in gastroenterology with daptomycin - first experiences from the EU-CORE registry study (European Cubicin® Outcomes Registry and Experience)].
Zeitschrift für Gastroenterologie 2012;50(4):373-81.
2012: Ganesh V Pusapati; An Rykx; Rita Derua; Tim Eiseler; Johan Van Lint; Sandy Vandoninck; Goetz von Wichert; Etienne Waelkens; Thomas Seufferlein
Protein kinase D regulates RhoA activity via rhotekin phosphorylation.
The Journal of biological chemistry 2012;287(12):9473-83.
2011: Sidney J Winawer; Meinhard Classen; Abdel Meguid Kassem; Robert C Kurtz; Reza Malekzadeh; Pankaj Jay Pasricha; Wolff Schmiegel; Thomas Seufferlein; Frank A Sinicrope; Joseph Sung; Guido N Tytgat
The future role of the gastroenterologist in digestive oncology: an international perspective.
Gastroenterology 2011;141(4):e13-21.
2011: Jens Walldorf; M M Dollinger; Thomas Seufferlein
[Pregnancy under immunosuppression].
Der Internist 2011;52(10):1178-84.
2011: Nadine Walter; Alexandre Micoulet; Thomas Seufferlein; Joachim P Spatz
Direct assessment of living cell mechanical responses during deformation inside microchannel restrictions.
Biointerphases 2011;6(3):117.
2011: Ninel Azoitei; Heinrich Baust; Cornelia Brunner; Alina Filatova; Felicitas Genze; Alexander Kleger; Rainer Kuefer; Peter Möller; Ganesh Varma Pusapati; Nina Schoo; Til Acker; Guido Adler; Dietmar Rudolf Thal; Johan Van Lint; Thomas Seufferlein
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
Neuro-oncology 2011;13(7):710-24.
2011: Nadine Walter; Tobias Busch; Thomas Seufferlein; Joachim P Spatz
Elastic moduli of living epithelial pancreatic cancer cells and their skeletonized keratin intermediate filament network.
Biointerphases 2011;6(2):79-85.
2011: Klaudia Giehl; Max G Bachem; Michael Beil; Bernhard O Böhm; Volker Ellenrieder; Simone Fulda; Thomas M Gress; Karlheinz Holzmann; Hans A Kestler; Marko Kornmann; Andre Menke; Peter Möller; Franz Oswald; Roland M Schmid; Volker Schmidt; Reinhold Schirmbeck; Thomas Seufferlein; Götz von Wichert; Martin Wagner; Paul Walther; Thomas Wirth; Guido Adler
Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm.
Pancreas 2011;40(4):489-502.
2011: Mirja Sargent; Stefan Boeck; Volker Heinemann; Karl-Walter Jauch; Thomas Seufferlein; Christiane J Bruns
Surgical treatment concepts for patients with pancreatic cancer in Germany--results from a national survey conducted among members of the "Chirurgische Arbeitsgemeinschaft Onkologie" (CAO) and the "Arbeitsgemeinschaft Internistische Onkologie" (AIO) of the Germany Cancer Society (DKG).
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2011;396(2):223-9.
2011: Alexander Kleger; Stefan Liebau; Qiong Lin; Götz von Wichert; Thomas Seufferlein
The impact of bioactive lipids on cardiovascular development.
Stem cells international 2011;2011():916180.
2011: Julia C Stingl; Martina Wiedom; Jürgen Brockmöller; Thomas Ettrich; Rainer Muche; Angela Seeringer; Thomas Seufferlein
Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population.
BMC cancer 2011;11():360.
2011: Alexander Kleger; Christiane Loebnitz; Ganesh V Pusapati; Milena Armacki; Martin Müller; Stefan Tümpel; Anett Illing; Daniel Hartmann; Cornelia Brunner; Stefan Liebau; Karl L Rudolph; Guido Adler; Thomas Seufferlein
Protein kinase D2 is an essential regulator of murine myoblast differentiation.
PloS one 2011;6(1):e14599.
2011: J Walldorf; K Zwirnmann; Thomas Seufferlein
[Pregnancy and inflammatory bowel disease].
Der Internist 2011;52(1):76, 78-80.
2010: Alexander Zipprich; M Winkler; Thomas Seufferlein; M M Dollinger
Comparison of balloon vs. straight catheter for the measurement of portal hypertension.
Alimentary pharmacology & therapeutics 2010;32(11-12):1351-6.
2010: Alexander Kleger; Thomas Seufferlein; Daniela Malan; Michael Tischendorf; Alexander Storch; Anne Wolheim; Stephan Latz; Stephanie Protze; Marc Porzner; Christian Proepper; Cornelia Brunner; Sarah-Fee Katz; Ganesh Varma Pusapati; Lars Bullinger; Wolfgang-Michael Franz; Ralf Koehntop; Klaudia Giehl; Andreas Spyrantis; Oliver H Wittekindt; Qiong Lin; Quiong Lin; Martin Zenke; Bernd K Fleischmann; Maria Wartenberg; Anna M Wobus; Tobias M Boeckers; Stefan Liebau
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
Circulation 2010;122(18):1823-36.
2010: Ninel Azoitei; Ganesh Varma Pusapati; Alexander Kleger; Peter Möller; Rainer Küfer; Felicitas Genze; Martin Wagner; Johan van Lint; Peter Carmeliet; Guido Adler; Thomas Seufferlein
Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.
Gut 2010;59(10):1316-30.
2010: Andreas Stang; Thomas Seufferlein
Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study.
Gastrointestinal endoscopy 2010;72(3):671-2.
2010: G von Wichert; Guido Adler; Thomas Seufferlein
[Personalized therapy of gastrointestinal cancers--possibilities and limitations].
Deutsche medizinische Wochenschrift (1946) 2010;135(34-35):1687-91.
2010: Alexander Zipprich; Oliver Kuss; Sebastian Rogowski; Gerhard Kleber; Erich Lotterer; Thomas Seufferlein; Wolfgang E Fleig; Matthias M Dollinger
Incorporating indocyanin green clearance into the Model for End Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to advanced cirrhosis.
Gut 2010;59(7):963-8.
2010: Dirk Arnold; Thomas Seufferlein
Targeted treatments in colorectal cancer: state of the art and future perspectives.
Gut 2010;59(6):838-58.
2010: Denis Krndija; H Schmid; J-L Eismann; U Lother; Guido Adler; Franz Oswald; Thomas Seufferlein; Goetz von Wichert
Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility.
Oncogene 2010;29(18):2724-38.
2010: Volker Kaechele; Markus Moehler; Manfred P Lutz; Goetz von Wichert; Miriam Eisele; Jochen Klaus; Peter R Galle; Guido Adler; Thomas Seufferlein
A phase I/II study of oxaliplatin and paclitaxel in patients with non-resectable cancer of the oesophagus and adenocarcinoma of the gastro-oesophageal junction: a study of the Arbeitsgemeinschaft Internistische Onkologie.
Cancer chemotherapy and pharmacology 2010;66(1):191-5.
2010: Jens Walldorf; Christoph Hillebrand; Hendryk Aurich; Peggy Stock; Madlen Hempel; Sabine Ebensing; Wolfgang E Fleig; Thomas Seufferlein; Matthias M Dollinger; Bruno Christ
Propranolol impairs liver regeneration after partial hepatectomy in C57Bl/6-mice by transient attenuation of hepatic lipid accumulation and increased apoptosis.
Scandinavian journal of gastroenterology 2010;45(4):468-76.
2010: Ganesh Varma Pusapati; Denis Krndija; Milena Armacki; Götz von Wichert; Julia von Blume; Vivek Malhotra; Guido Adler; Thomas Seufferlein
Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport.
Molecular biology of the cell 2010;21(6):1011-22.
2010: Thomas Seufferlein; Guido Adler
[Clinical research in Germany at the example of oncology].
Onkologie 2010;33 Suppl 7():1-5.
2010: Dirk Arnold; Hans-Joachim Schmoll; Hauke Lang; Wolfram Trudo Knoefel; Karsten Ridwelski; Tanja Trarbach; Ludger Staib; Thomas Kirchner; Michael Geissler; Thomas Seufferlein; Holger Amthauer; Hanno Riess; Hans J Schlitt; Pompiliu Piso
[Specific treatment situations in metastatic colorectal cancer].
Onkologie 2010;33 Suppl 4():8-18.
2010: Claudio G Rolli; Thomas Seufferlein; Ralf Kemkemer; Joachim P Spatz
Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach.
PloS one 2010;5(1):e8726.
2010: Wolff Schmiegel; Christian Pox; Anke Reinacher-Schick; G Adler; D Arnold; WE Fleig; Ulrich R Fölsch; P Frühmorgen; Ullrich Graeven; V Heinemann; W Hohenberger; A Holstege; T Junginger; I Kopp; T Kühlbacher; Rainer Porschen; P Propping; JF Riemann; C Rödel; R Sauer; T Sauerbruch; W Schmitt; HJ Schmoll; Thomas Seufferlein; M Zeitz; HK Selbmann
S3 guidelines for colorectal carcinoma: results of an evidence-based consensus conference on February 6/7, 2004 and June 8/9, 2007 (for the topics IV, VI and VII).
Zeitschrift für Gastroenterologie 2010;48(1):65-136.
2009: Thomas Seufferlein; Guido Adler
[The S3 guideline exocrine pancreatic cancer].
Medizinische Klinik (Munich, Germany : 1983) 2009;104(11):869-74.
2009: Marc Porzner; Tobias Müller; Thomas Seufferlein
SR 57746A/xaliproden, a non-peptide neurotrophic compound: prospects and constraints for the treatment of nervous system diseases.
Expert opinion on investigational drugs 2009;18(11):1765-72.
2009: C Lübbert; C Taege; Thomas Seufferlein; R Grunow
[Prolonged course of tick-borne ulceroglandular tularemia in a 20-year-old patient in Germany--case report and review of the literature].
Deutsche medizinische Wochenschrift (1946) 2009;134(27):1405-10.
2009: Christoph Lübbert; Jörg G Albert; Michael Hainz; Annett Pudszuhn; Thomas Seufferlein
[Tonsillar actinomycosis as a rare cause of oral malodor. Diagnosis beyond a gastroenterologist's nose].
Medizinische Klinik (Munich, Germany : 1983) 2009;104(6):480-3.
2009: Jens Walldorf; Christian Wittekind; Wolfgang E Fleig; Hans-Jürgen Holzhausen; Utz Settmacher; Thomas Seufferlein; Andrea Tannapfel; Matthias M Dollinger
Rapid development of a hepatocellular carcinoma in isolated thrombosis of hepatic veins (classic Budd-Chiari syndrome): case report and review of literature.
BMJ case reports 2009;2009():.
2009: Thomas Seufferlein; Johann Ahn; Denis Krndija; Ulrike Lother; Guido Adler; Goetz von Wichert
Tumor biology and cancer therapy - an evolving relationship.
Cell communication and signaling : CCS 2009;7():19.
2009: Stefan Boeck; Christiane J Bruns; Mirja Sargent; Claus Schafer; Thomas Seufferlein; Karl-Walter Jauch; Volker Heinemann
Current oncological treatment of patients with pancreatic cancer in germany: results from a national survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society.
Oncology 2009;77(1):40-8.
2009: Angela Märten; Jan Schmidt; Jennifer Ose; Sabine Harig; Ulrich Abel; Marc W Münter; Dirk Jäger; Helmut Friess; Julia Mayerle; Guido Adler; Thomas Seufferlein; Thomas Gress; Roland Schmid; Markus W Büchler
A randomized multicentre phase II trial comparing adjuvant therapy in patients with interferon alpha-2b and 5-FU alone or in combination with either external radiation treatment and cisplatin (CapRI) or radiation alone regarding event-free survival - CapRI-2.
BMC cancer 2009;9():160.
2009: Andre Mihaljevic; Peter Büchler; Jan Harder; Ralf Hofheinz; Michael Gregor; Stephan Kanzler; Wolff Schmiegel; Volker Heinemann; Esther Endlicher; Günter Klöppel; Thomas Seufferlein; Michael Geissler
A prospective, non-randomized phase II trial of Trastuzumab and Capecitabine in patients with HER2 expressing metastasized pancreatic cancer.
BMC surgery 2009;9():1.
2008: Wolff Schmiegel; Anke Reinacher-Schick; D Arnold; Ullrich Graeven; V Heinemann; Rainer Porschen; JF Riemann; C Rödel; R Sauer; M Wieser; W Schmitt; HJ Schmoll; Thomas Seufferlein; I Kopp; Christian Pox
[Update S3-guideline "colorectal cancer" 2008].
Zeitschrift für Gastroenterologie 2008;46(8):799-840.
2008: Volker Kaechele; Thomas Seufferlein; Sandra Pauls
Electronic clinical challenges and images in GI. Pneumatosis cystoides intestinalis.
Gastroenterology 2008;135(2):e4-5.
2008: Goetz von Wichert; Teresa Edenfeld; Julia von Blume; Holger Krisp; Denis Krndija; Heidrun Schmid; Franz Oswald; Ulrike Lother; Paul Walther; Guido Adler; Thomas Seufferlein
Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells.
Cellular signalling 2008;20(5):925-34.
2008: Shaoxia Zhou; Max G Bachem; Thomas Seufferlein; Yiping Li; Hans-Jürgen Gross; Andreas Schmelz
Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity.
Cellular signalling 2008;20(4):695-704.
2008: E Zizer; Cornelia Hasel; Thomas Seufferlein; Guido Adler; N Dikopoulos
[A 40-year-old female patient with seronegative autoimmune hepatitis following a newly acquired hepatitis B infection].
Zeitschrift für Gastroenterologie 2008;46(2):201-5.
2008: Goetz von Wichert; Thomas Seufferlein; Guido Adler
Palliative treatment of pancreatic cancer.
Journal of digestive diseases 2008;9(1):1-7.
2008: Volker Kaechele; Goetz von Wichert; Guido Adler; Thomas Seufferlein
Response to reintroduction of cetuximab in 5 patients with advanced, chemotherapy-resistant, colorectal cancer without progressive disease following first-line therapy with a cetuximab-containing regimen.
Oncology 2008;74(3-4):123-6.
2008: Hendrik-Tobias Arkenau; Ullrich Graeven; Stephan Kubicka; Axel Grothey; Christina Englisch-Fritz; Albrecht Kretzschmar; richard greil; Werner Freier; Thomas Seufferlein; Axel Hinke; Hans-Joachim Schmoll; Wolff Schmiegel; Rainer Porschen
Oxaliplatin in combination with 5-fluorouracil/leucovorin or capecitabine in elderly patients with metastatic colorectal cancer.
Clinical colorectal cancer 2008;7(1):60-4.
2008: Goetz von Wichert; Denis Krndija; Heidrun Schmid; Georg von Wichert; Georg Haerter; Guido Adler; Thomas Seufferlein; Michael P Sheetz
Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines.
European journal of cell biology 2008;87(1):1-16.
2008: Thorsten Cramer; Stefan Jüttner; Thomas Plath; Stefan Mergler; Thomas Seufferlein; Timothy C Wang; Juanita L Merchant; Michael Höcker
Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB.
Cellular signalling 2008;20(1):60-72.
2007: Goetz von Wichert; Thomas Seufferlein
[Adjuvant chemotherapy of solid tumors of the gastrointestinal tract: where is the progress?].
Der Internist 2007;48(12):1335-42.
2007: Julia von Blume; Uwe Knippschild; Franck Dequiedt; Georgios Giamas; Alexander Beck; Alexandra Auer; Johan Van Lint; Guido Adler; Thomas Seufferlein
Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.
The EMBO journal 2007;26(22):4619-33.
2007: Ninel Azoitei; A Brey; T Busch; Simone Fulda; Guido Adler; Thomas Seufferlein
Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation.
Oncogene 2007;26(45):6536-45.
2007: Rainer Porschen; Hendrik-Tobias Arkenau; Stephan Kubicka; richard greil; Thomas Seufferlein; Werner Freier; Albrecht Kretzschmar; Ullrich Graeven; Axel Grothey; Axel Hinke; Wolff Schmiegel; Hans-Joachim Schmoll
Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(27):4217-23.
2007: Guido Adler; Thomas Seufferlein
[ZfG 2007: A successful interim result].
Zeitschrift für Gastroenterologie 2007;45(9):943.
2007: Thomas Seufferlein; G V Wichert; Guido Adler
[Pharmacotherapy of colon cancer].
Deutsche medizinische Wochenschrift (1946) 2007;132(38):1951-62.
2007: Guido Adler; Thomas Seufferlein; S C Bischoff; H-J Brambs; S Feuerbach; G Grabenbauer; S Hahn; V Heinemann; W Hohenberger; J M Langrehr; Manfred P Lutz; O Micke; H Neuhaus; P Neuhaus; H Oettle; P M Schlag; R Schmid; Wolff Schmiegel; K Schlottmann; J Werner; B Wiedenmann; I Kopp
[Carcinoma of the pancreas: summary of guidelines 2007, issued jointly by 15 German specialist medical societies].
Deutsche medizinische Wochenschrift (1946) 2007;132(33):1696-700.
2007: Guido Adler; Thomas Seufferlein; S C Bischoff; Hans-Juergen Brambs; S Feuerbach; G Grabenbauer; S Hahn; V Heinemann; W Hohenberger; J M Langrehr; Manfred P Lutz; O Micke; H Neuhaus; P Neuhaus; H Oettle; P M Schlag; R Schmid; Wolff Schmiegel; K Schlottmann; J Werner; B Wiedenmann; I Kopp
[S3-Guidelines "Exocrine pancreatic cancer" 2007].
Zeitschrift für Gastroenterologie 2007;45(6):487-523.
2007: Thomas Seufferlein; Goetz von Wichert; Guido Adler
[Palliative treatment of pancreatic cancer].
Deutsche medizinische Wochenschrift (1946) 2007;132(15):813-7.
2007: Volker Kächele; Sandra Pauls; Felix Mottaghy; Norbert M Blumstein; Hans-Juergen Brambs; Thomas F E Barth; Andreas Hannekum; Martin Höher; Martin Jeltsch; Sven N Reske; Peter Möller; Guido Adler; Thomas Seufferlein
A 25-year-old woman with a gastric GIST and a PET-positive epicardial tumor.
Nature clinical practice. Oncology 2007;4(3):197-201.
2007: Wilhelm Schneiderhan; Fredy Diaz; Martin Fundel; Shaoxia Zhou; Marco Siech; Cornelia Hasel; Peter Möller; Juergen E Gschwend; Thomas Seufferlein; Thomas M Gress; Guido Adler; Max G Bachem
Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay.
Journal of cell science 2007;120(Pt 3):512-9.
2007: Alexander Kleger; Tobias Busch; Stefan Liebau; Katja Prelle; Stephan Paschke; Michael Beil; Alexandra Rolletschek; Anna M Wobus; Eckhard Wolf; Guido Adler; Thomas Seufferlein
The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
Cellular signalling 2007;19(2):367-77.
2007: Guido Adler; Thomas Seufferlein
[Hope and disappointment in cancer medicine].
Zeitschrift für ärztliche Fortbildung und Qualitätssicherung 2007;101(5):287-92.
2006: Anke Reinacher-Schick; D Arnold; F Lordick; M Möhler; Manfred P Lutz; Thomas Seufferlein
[ASCO update 2006--highlights of the 42. meeting of the American Society of Clinical Oncology/ASCO 2006].
Zeitschrift für Gastroenterologie 2006;44(10):1065-72.
2006: Franck Dequiedt; Maud Martin; Julia von Blume; Didier Vertommen; Emily Lecomte; Nathalie Mari; Marie-France Heinen; Malte Bachmann; Jean-Claude Twizere; Mei Chris Huang; Mark H Rider; Helen Piwnica-Worms; Thomas Seufferlein; Richard Kettmann
New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.
Molecular and cellular biology 2006;26(19):7086-102.
2006: Gunnar Folprecht; Manfred P Lutz; P Schöffski; Thomas Seufferlein; A Nolting; P Pollert; Claus-Henning Köhne
Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(3):450-6.
2005: Thomas Höhler; Michael Heike; Manfred P Lutz; Ullrich Graeven; Thomas Seufferlein
[ASCO-Update 2005--Highlights of the 41st Meeting of the American Society of Clinical Oncology/ASCO 2005].
Zeitschrift für Gastroenterologie 2005;43(11):1253-9.
2005: Alexandra Auer; Julia von Blume; Sabine Sturany; Goetz von Wichert; Johan Van Lint; Jackie R Vandenheede; Guido Adler; Thomas Seufferlein
Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.
Molecular biology of the cell 2005;16(9):4375-85.
2005: Benjamin Boesler; David Czock; Frieder Keller; Martin Griesshammer; Thomas Seufferlein; Wolfram Karges; Franz Maximilian Rasche
Clinical course of haemodialysis patients with malignancies and dose-adjusted chemotherapy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2005;20(6):1187-91.
2005: Franck Dequiedt; Johan Van Lint; Emily Lecomte; Viktor Van Duppen; Thomas Seufferlein; Jackie R Vandenheede; Ruddy Wattiez; Richard Kettmann
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis.
The Journal of experimental medicine 2005;201(5):793-804.
2005: Goetz von Wichert; Ulla Haeussler; Florian R Greten; Stefanie Kliche; Henning Dralle; Bernhard O Böhm; Guido Adler; Thomas Seufferlein
Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.
Oncogene 2005;24(7):1284-9.
2005: Subra Suresh; Joachim P Spatz; JP Mills; Alexandre Micoulet; Ming Dao; Chwee Teck Lim; Michael Beil; Thomas Seufferlein
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
Acta biomaterialia 2005;1(1):15-30.
2004: Shaoxia Zhou; Andreas Schmelz; Thomas Seufferlein; Yiping Li; Jinshun Zhao; Max G Bachem
Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts.
The Journal of biological chemistry 2004;279(52):54463-9.
2004: Tamara Mihailovic; Martin Marx; Alexandra Auer; Johan Van Lint; Mathias Schmid; Christoph Weber; Thomas Seufferlein
Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells.
Cancer research 2004;64(24):8939-44.
2004: Ullrich Graeven; Michael Heike; Thomas Höhler; Manfred P Lutz; Helmut Messmann; Thomas Seufferlein; T Eberl
[ASCO update -- highlights of the 40th Meeting of the American Society of Clinical Oncology/ASCO 2004].
Zeitschrift für Gastroenterologie 2004;42(12):1416-24.
2004: Volker Kächele; P Hahn; Guido Adler; Thomas Seufferlein
[Chemotherapy for colorectal carcinoma in the elderly].
Zeitschrift für Gastroenterologie 2004;42(10):1189-98.
2004: Tibor Vantus; Didier Vertommen; Xavier Saelens; An Rykx; Line De Kimpe; Sadia Vancauwenbergh; Svitlana V Mikhalap; Etienne Waelkens; György Kéri; Thomas Seufferlein; Peter Vandenabeele; Mark H Rider; Jackie R Vandenheede; Johan Van Lint
Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing.
Cellular signalling 2004;16(6):703-9.
2004: Charles Yeaman; M Inmaculada Ayala; Jessica R Wright; Frederic Bard; Carine Bossard; Agnes Ang; Yusuke Maeda; Thomas Seufferlein; Ira Mellman; W James Nelson; Vivek Malhotra
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.
Nature cell biology 2004;6(2):106-12.
2003: Heinrich Baust; A Schoke; A Brey; Ulrike Gern; Marek Los; Roland M Schmid; Erwin M Röttinger; Thomas Seufferlein
Evidence for radiosensitizing by gliotoxin in HL-60 cells: implications for a role of NF-kappaB independent mechanisms.
Oncogene 2003;22(54):8786-96.
2003: T Eberl; Ullrich Graeven; Michael Heike; Thomas Höhler; Manfred P Lutz; Helmut Messmann; Thomas Seufferlein
[ASCO Update 2003 - Highlights of the 39th Meeting of the American Society of Clinical Oncology/ASCO 2003].
Zeitschrift für Gastroenterologie 2003;41(10):1039-45.
2003: Michael Beil; Alexandre Micoulet; Goetz von Wichert; Stephan Paschke; Paul Walther; Bishr Omary; Paul P Van Veldhoven; Ulrike Gern; Elke Wolff-Hieber; Juliane Eggermann; Johannes Waltenberger; Guido Adler; Joachim P Spatz; Thomas Seufferlein
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
Nature cell biology 2003;5(9):803-11.
2003: An Rykx; Line De Kimpe; Svitlana V Mikhalap; Tibor Vantus; Thomas Seufferlein; Jackie R Vandenheede; Johan Van Lint
Protein kinase D: a family affair.
FEBS letters 2003;546(1):81-6.
2003: Martin Steinkamp; Irmlind Geerling; Thomas Seufferlein; Georg B T Von Boyen; Bernhard Egger; Johannes Grossmann; Leopold Ludwig; Guido Adler; Max Reinshagen
Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells.
Gastroenterology 2003;124(7):1748-57.
2003: F Mueller; Martin Bommer; U Lacher; C Ruhland; Volker Stagge; Guido Adler; Thomas M Gress; Thomas Seufferlein
KOC is a novel molecular indicator of malignancy.
British journal of cancer 2003;88(5):699-701.
2003: Thomas Seufferlein; Manfred P Lutz; Guido Adler
[Multimodal therapy in colon carcinoma].
Der Internist 2003;44(3):322-30, 332-5.
2002: Thomas Seufferlein; Bernhard O Boehm
The impact of pharmacogenomics on gastrointestinal cancer therapy.
Pharmacogenomics 2002;3(5):625-33.
2002: Sabine Sturany; Johan Van Lint; Annette Gilchrist; Jackie R Vandenheede; Guido Adler; Thomas Seufferlein
Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor.
The Journal of biological chemistry 2002;277(33):29431-6.
2002: Thomas Seufferlein; M J Seckl; E Schwarz; Michael Beil; G v Wichert; Heinrich Baust; H Lührs; Roland M Schmid; Guido Adler
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
British journal of cancer 2002;86(7):1188-96.
2002: Johan Van Lint; An Rykx; Yusuke Maeda; Tibor Vantus; Sabine Sturany; Vivek Malhotra; Jackie R Vandenheede; Thomas Seufferlein
Protein kinase D: an intracellular traffic regulator on the move.
Trends in cell biology 2002;12(4):193-200.
2002: Michael Beil; Jürgen Leser; Manfred P Lutz; Anna S Gukovskaya; Thomas Seufferlein; Grit Lynch; Stephen J Pandol; Guido Adler
Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(3):G450-60.
2002: Thomas Seufferlein
Novel protein kinases in pancreatic cell growth and cancer.
International journal of gastrointestinal cancer 2002;31(1-3):15-21.
2001: Bertram Poch; Frank Gansauge; A Schwarz; Thomas Seufferlein; T Schnelldorfer; Marco Ramadani; Hans G Beger; Susanne Gansauge
Epidermal growth factor induces cyclin D1 in human pancreatic carcinoma: evidence for a cyclin D1-dependent cell cycle progression.
Pancreas 2001;23(3):280-7.
2001: Volker Stagge; Thomas Seufferlein; D Dürschmied; Andre Menke; Guido Adler; D Duerschmied; Michael Beil
Integrin-mediated differentiation of a pancreatic carcinoma cell line is independent of FAK or MAPK activation levels.
Pancreas 2001;23(3):236-45.
2001: Volker Ellenrieder; SF Hendler; WG Boeck; Thomas Seufferlein; Andre Menke; C Ruhland; Guido Adler; Thomas M Gress
Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation.
Cancer research 2001;61(10):4222-8.
2001: Sabine Sturany; Johan Van Lint; F Muller; Monika Wilda; Horst Hameister; M Hocker; A Brey; Ulrike Gern; Jackie R Vandenheede; Thomas M Gress; Guido Adler; Thomas Seufferlein
Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases.
The Journal of biological chemistry 2001;276(5):3310-8.
2000: Goetz von Wichert; Peter M Jehle; Andreas Hoeflich; S Koschnick; Henning Dralle; E Wolf; B Wiedenmann; Bernhard O Boehm; Guido Adler; Thomas Seufferlein
Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells.
Cancer research 2000;60(16):4573-81.
1999: M Grewe; Frank Gansauge; Roland M Schmid; Guido Adler; Thomas Seufferlein
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.
Cancer research 1999;59(15):3581-7.
1999: Thomas Seufferlein; Johan Van Lint; Susanne Liptay; Guido Adler; Roland M Schmid
Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations.
Gastroenterology 1999;116(6):1441-52.
1998: S C Schwarz; Thomas Seufferlein; Susanne Liptay; Roland M Schmid; K Kasischke; O J Foster; S Daniel; Johannes Schwarz
Microglial activation in multiple system atrophy: a potential role for NF-kappaB/rel proteins.
Neuroreport 1998;9(13):3029-32.
1998: Susanne Gansauge; Frank Gansauge; Y Yang; J Müller; Thomas Seufferlein; Marco Ramadani; Hans G Beger
Interleukin 1beta-converting enzyme (caspase-1) is overexpressed in adenocarcinoma of the pancreas.
Cancer research 1998;58(13):2703-6.