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Alex Strongin

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Shaoying Lu; Howard Ozer; Yijia Pan; Alex Y Strongin; Stephen A Boppart; Eric J Chaney; He Huang; Yi Wang; Yingxiao Wang
Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.
Sergey A Shiryaev; Alex Y Strongin; Elliot R Thomsen; Vladislav Golubkov; Igor A Kozlov; Mark S Chee; Andrei V Chernov; Eugene Chudin; Piotr Cieplak
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.
Vladislav Golubkov; Alex Y Strongin
Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).

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2013: Shaoying Lu; Howard Ozer; Yijia Pan; Alex Y Strongin; Stephen A Boppart; Eric J Chaney; He Huang; Yi Wang; Yingxiao Wang
Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells.
PloS one 2013;8(3):e58569.
2013: Sergey A Shiryaev; Alex Y Strongin; Elliot R Thomsen; Vladislav Golubkov; Igor A Kozlov; Mark S Chee; Andrei V Chernov; Eugene Chudin; Piotr Cieplak
High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.
PloS one 2013;8(1):e54290.
2012: Vladislav Golubkov; Alex Y Strongin
Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).
The Journal of biological chemistry 2012;287(50):42009-18.
2012: Alexander E Aleshin; Marcin Drag; Naran Gombosuren; Robert C Liddington; Jowita Mikolajczyk; Arnold C Satterthwait; Alex Y Strongin; Ge Wei; Guy S Salvesen
Activity, specificity, and probe design for the smallpox virus protease K7L.
The Journal of biological chemistry 2012;287(47):39470-9.
2012: Albert G Remacle; Sergey A Shiryaev; John L Stebbins; Anton V Cheltsov; Andrei V Chernov; Russell Dahl; Vladislav S Golubkov; Maurizio Pellecchia; Alex Y Strongin
Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.
Cancer research 2012;72(9):2339-49.
2012: Sergey A Shiryaev; Anton V Cheltsov; Alex Y Strongin
Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase.
PloS one 2012;7(7):e40029.
2012: Huaqing Liu; Albert G Remacle; Sergey A Shiryaev; Igor Shubayev; Svetlana Baranovskaya; Andrei V Chernov; Vladislav S Golubkov; Youngsoon Kim; Alex Y Strongin; Veronica I Shubayev
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.
Journal of neuroinflammation 2012;9():119.
2012: Sergey A Shiryaev; Elliot R Thomsen; Mark S Chee; Anton V Cheltsov; Eugene Chudin; Piotr Cieplak; Igor A Kozlov; Alex Y Strongin
New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.
PloS one 2012;7(4):e35759.
2012: Youngsoon Kim; Calvin Lai; Huaqing Liu; Andrew P Mizisin; Albert G Remacle; Sergey A Shiryaev; Igor Shubayev; Andrei V Chernov; Jennifer Dolkas; Vladislav S Golubkov; Alex Y Strongin; Veronica I Shubayev
The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.
PloS one 2012;7(3):e33664.
2011: Vladislav S Golubkov; Andrei V Chernov; Alex Y Strongin
Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.
The Journal of biological chemistry 2011;286(39):34215-23.
2011: Sergey A Shiryaev; Alexander Sloutsky; Alexander E Aleshin; Piotr Cieplak; Khatereh Motamedchaboki; Qing Sun; Wenhong Zhu; Alex Y Strongin
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
The FEBS journal 2011;278(18):3277-86.
2011: Albert G Remacle; Sergey A Shiryaev; Ilian A Radichev; Dmitri V Rozanov; Boguslaw Stec; Alex Y Strongin
Dynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases by tissue inhibitors of metalloproteinases.
The Journal of biological chemistry 2011;286(23):21002-12.
2011: Vladislav S Golubkov; Alexander E Aleshin; Alex Y Strongin
Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.
The Journal of biological chemistry 2011;286(23):20970-6.
2011: Sergey A Shiryaev; Anton V Cheltsov; Katarzyna Gawlik; Boris I Ratnikov; Alex Y Strongin
Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.
Assay and drug development technologies 2011;9(1):69-78.
2011: Sergey A Shiryaev; Andrei V Chernov; Tatiana N Shiryaeva; Alexander E Aleshin; Alex Y Strongin
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.
Archives of virology 2011;156(2):313-8.
2010: Vladislav S Golubkov; Alexei V Chekanov; Piotr Cieplak; Alexander E Aleshin; Andrei V Chernov; Wenhong Zhu; Ilian A Radichev; Danhua Zhang; P Duc Dong; Alex Y Strongin
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
The Journal of biological chemistry 2010;285(46):35740-9.
2010: Vladislav Golubkov; Piotr Cieplak; Alexei V Chekanov; Boris I Ratnikov; Alexander E Aleshin; Natalya V Golubkova; Tatiana I Postnova; Ilian A Radichev; Dmitri V Rozanov; Wenhong Zhu; Khatereh Motamedchaboki; Alex Y Strongin
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
The Journal of biological chemistry 2010;285(36):27726-36.
2010: Andrei V Chernov; Svetlana Baranovskaya; Vladislav S Golubkov; Dustin R Wakeman; Evan Y Snyder; Roy Williams; Alex Y Strongin
Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer.
The Journal of biological chemistry 2010;285(25):19647-59.
2010: Albert G Remacle; Katarzyna Gawlik; Vladislav S Golubkov; Gregory W Cadwell; Robert C Liddington; Piotr Cieplak; Sherri Z Millis; Roxane Desjardins; Sophie Routhier; Xue Wen Yuan; Witold A Neugebauer; Robert Day; Alex Y Strongin
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
The international journal of biochemistry & cell biology 2010;42(6):987-95.
2010: Ilian A Radichev; Albert G Remacle; Sergey A Shiryaev; Angela N Purves; Sherida L Johnson; Maurizio Pellecchia; Alex Y Strongin
Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase.
The Journal of biological chemistry 2010;285(21):16076-86.
2010: Sergey A Shiryaev; Ilian A Radichev; Boris I Ratnikov; Alexander E Aleshin; Katarzyna Gawlik; Boguslaw Stec; Christian Frisch; Achim Knappik; Alex Y Strongin
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.
The Biochemical journal 2010;427(3):369-76.
2010: Mingxing Ouyang; He Huang; Nathan C Shaner; Albert G Remacle; Sergey A Shiryaev; Alex Y Strongin; Roger Y Tsien; Yingxiao Wang
Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.
Cancer research 2010;70(6):2204-12.
2010: Nor Eddine SOUNNI; Dmitri V Rozanov; Albert G Remacle; Vladislav Golubkov; Agnès Noel; Alex Y Strongin
Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.
International journal of cancer. Journal international du cancer 2010;126(5):1067-78.
2010: Katarzyna Gawlik; Albert G Remacle; Sergey A Shiryaev; Vladislav Golubkov; Mingxing Ouyang; Yingxiao Wang; Alex Y Strongin
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.
PloS one 2010;5(6):e11305.
2010: Alex Y Strongin
Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy.
Biochimica et biophysica acta 2010;1803(1):133-41.
2009: Alexander E Aleshin; Svetlana Gramatikova; Gregory L Hura; Andrey Bobkov; Alex Y Strongin; Boguslaw Stec; John A Tainer; Robert C Liddington; Jeffrey W Smith
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.
Structure (London, England : 1993) 2009;17(11):1465-75.
2009: Sergey A Shiryaev; Albert G Remacle; Alexei Y Savinov; Andrei V Chernov; Piotr Cieplak; Ilian A Radichev; Roy Williams; Tatiana N Shiryaeva; Katarzyna Gawlik; Tatiana I Postnova; Boris I Ratnikov; Alexey Eroshkin; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
The Journal of biological chemistry 2009;284(44):30615-26.
2009: Shyama Sidique; Sergey A Shiryaev; Boris I Ratnikov; Ananda Herath; Ying Su; Alex Y Strongin; Nicholas D P Cosford
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.
Bioorganic & medicinal chemistry letters 2009;19(19):5773-7.
2009: Sergey A Shiryaev; Andrei V Chernov; Alexander E Aleshin; Tatiana N Shiryaeva; Alex Y Strongin
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.
The Journal of general virology 2009;90(Pt 9):2081-5.
2009: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Olga L Rozanova; Tatiana I Postnova; Eduard A Sergienko; Stefan Vasile; Alexander E Aleshin; Michele F Rega; Surya De; Alex Y Strongin
Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells.
Molecular cancer therapeutics 2009;8(6):1515-25.
2009: Ilian A Radichev; Albert G Remacle; Nor Eddine SOUNNI; Sergey A Shiryaev; Dmitri V Rozanov; Wenhong Zhu; Natalya V Golubkova; Tatiana I Postnova; Vladislav Golubkov; Alex Y Strongin
Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.
The Biochemical journal 2009;420(1):37-47.
2009: Andrei V Chernov; Nor Eddine SOUNNI; Albert G Remacle; Alex Y Strongin
Epigenetic control of the invasion-promoting MT1-MMP/MMP-2/TIMP-2 axis in cancer cells.
The Journal of biological chemistry 2009;284(19):12727-34.
2009: Seung-Hee Lee; Ergeng Hao; Alexei Y Savinov; Ifat Geron; Alex Y Strongin; Pamela Itkin-Ansari
Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.
Transplantation 2009;87(7):983-91.
2009: Katarzyna Gawlik; Sergey A Shiryaev; Wenhong Zhu; Khatereh Motamedchaboki; Roxane Desjardins; Robert Day; Albert G Remacle; Boguslaw Stec; Alex Y Strongin
Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.
PloS one 2009;4(4):e5031.
2009: Sergey A Shiryaev; Alexei Y Savinov; Piotr Cieplak; Boris I Ratnikov; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.
PloS one 2009;4(3):e4952.
2009: Alexei Y Savinov; Alex Y Strongin
Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.
Vitamins and hormones 2009;80():541-62.
2008: Albert G Remacle; Sergey A Shiryaev; Eok-Soo Oh; Piotr Cieplak; Anupama Srinivasan; Ge Wei; Robert C Liddington; Boris I Ratnikov; Amelie Parent; Roxane Desjardins; Robert Day; Jeffrey W Smith; Michal Lebl; Alex Y Strongin
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.
The Journal of biological chemistry 2008;283(30):20897-906.
2008: Andrei V Chernov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
The Journal of biological chemistry 2008;283(25):17270-8.
2008: Dmitri V Rozanov; Alexei Y Savinov; Roy Williams; Kang Liu; Vladislav Golubkov; Stan Krajewski; Alex Y Strongin
Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.
Cancer research 2008;68(11):4086-96.
2008: Ilian Radichev; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase.
The Journal of general virology 2008;89(Pt 3):636-41.
2008: Shjerida Johnson; Li-Hsing Chen; Rebecca Harbach; Mojgan Sabet; Alexei Y Savinov; Naomi J H Cotton; Alex Y Strongin; Donald G Guiney; Maurizio Pellecchia
Rhodanine derivatives as selective protease inhibitors against bacterial toxins.
Chemical biology & drug design 2008;71(2):131-9.
2008: Yunfei Wen; Vladislav Golubkov; Alex Y Strongin; Wei Jiang; John C Reed
Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.
The Journal of biological chemistry 2008;283(5):2793-803.
2008: Silvia D'Alessio; Giovanni Ferrari; Karma Cinnante; William Scheerer; Aubrey C Galloway; Daniel F Roses; Dmitri V Rozanov; Albert G Remacle; Eok-Soo Oh; Sergey A Shiryaev; Alex Y Strongin; GIUSEPPE PINTUCCI; Paolo Mignatti
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.
The Journal of biological chemistry 2008;283(1):87-99.
2008: Christopher C Leonardo; Autumn K Eakin; Joanne M Ajmo; Lisa A Collier; Keith R Pennypacker; Alex Y Strongin; Paul Gottschall
Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat.
Journal of neuroinflammation 2008;5():34.
2007: Vladislav Golubkov; Alexei V Chekanov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Katarzyna Gawlik; Ilian Radichev; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
The Journal of biological chemistry 2007;282(50):36283-91.
2007: Paul A Johnston; Jennifer Phillips; Tong Ying Shun; Sunita Shinde; John Lazo; Donna M Huryn; Michael C Myers; Boris I Ratnikov; Jeffrey W Smith; Ying Su; Russell Dahl; Nicholas Cosford; Sergey A Shiryaev; Alex Y Strongin
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.
Assay and drug development technologies 2007;5(6):737-50.
2007: Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice.
The Journal of biological chemistry 2007;282(44):32106-11.
2007: Sergey A Shiryaev; Albert G Remacle; Boris I Ratnikov; Nicholas A Nelson; Alexei Y Savinov; Ge Wei; Massimo Bottini; Michele F Rega; Amelie Parent; Roxane Desjardins; Martin Fugere; Robert Day; Mojgan Sabet; Maurizio Pellecchia; Robert C Liddington; Jeffrey W Smith; Tomas Mustelin; Donald G Guiney; Michal Lebl; Alex Y Strongin
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
The Journal of biological chemistry 2007;282(29):20847-53.
2007: Alexander E Aleshin; Sergey A Shiryaev; Alex Y Strongin; Robert C Liddington
Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.
Protein science : a publication of the Protein Society 2007;16(5):795-806.
2007: Sergey A Shiryaev; Boris I Ratnikov; Alexander E Aleshin; Igor A Kozlov; Nicholas A Nelson; Michal Lebl; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis.
Journal of virology 2007;81(9):4501-9.
2007: Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region.
Protein expression and purification 2007;52(2):334-9.
2007: Sergey A Shiryaev; Igor A Kozlov; Boris I Ratnikov; Jeffrey W Smith; Michal Lebl; Alex Y Strongin
Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses.
The Biochemical journal 2007;401(3):743-52.
2007: Vladislav Golubkov; Alex Y Strongin
Proteolysis-driven oncogenesis.
Cell cycle (Georgetown, Tex.) 2007;6(2):147-50.
2007: Alexei Y Savinov; Alex Y Strongin
Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.
IUBMB life 2007;59(1):6-13.
2006: Vladislav Golubkov; Alexei V Chekanov; Alexei Y Savinov; Dmitri V Rozanov; Natalya V Golubkova; Alex Y Strongin
Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells.
Cancer research 2006;66(21):10460-5.
2006: Albert G Remacle; Dmitri V Rozanov; Martin Fugere; Robert Day; Alex Y Strongin
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Oncogene 2006;25(41):5648-55.
2006: Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1793-801.
2006: Albert G Remacle; Alexei V Chekanov; Vladislav Golubkov; Alexei Y Savinov; Dmitri V Rozanov; Alex Y Strongin
O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).
The Journal of biological chemistry 2006;281(25):16897-905.
2006: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Stephen Tomlinson; Alex Y Strongin
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Cancer research 2006;66(12):6258-63.
2006: Alex Y Strongin
Mislocalization and unconventional functions of cellular MMPs in cancer.
Cancer metastasis reviews 2006;25(1):87-98.
2006: Alexei Y Savinov; Albert G Remacle; Vladislav Golubkov; Maryla Krajewska; Susan Kennedy; Michael J Duffy; Dmitri V Rozanov; Stan Krajewski; Alex Y Strongin
Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.
Cancer research 2006;66(5):2716-24.
2006: Alexei V Chekanov; Albert G Remacle; Vladislav Golubkov; Vladimir S Akatov; Sergey Sikora; Alexei Y Savinov; Martin Fugere; Robert Day; Dmitri V Rozanov; Alex Y Strongin
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.
Archives of biochemistry and biophysics 2006;446(1):52-9.
2006: Sergey A Shiryaev; Boris I Ratnikov; Alexei V Chekanov; Sergey Sikora; Dmitri V Rozanov; Adam Godzik; Jun Wang; Jeffrey W Smith; Ziwei Huang; Iris Lindberg; Melanie A Samuel; Michael S Diamond; Alex Y Strongin
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.
The Biochemical journal 2006;393(Pt 2):503-11.
2006: Shjerida Johnson; Dawoon Jung; Martino Forino; Ya Chen; Arnold C Satterthwait; Dmitri V Rozanov; Alex Y Strongin; Surya De
Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.
Journal of medicinal chemistry 2006;49(1):27-30.
2005: Vladislav Golubkov; Alexei V Chekanov; Stephen J Doxsey; Alex Y Strongin
Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.
The Journal of biological chemistry 2005;280(51):42237-41.
2005: Albert G Remacle; Dmitri V Rozanov; Peter C Baciu; Alexei V Chekanov; Vladislav Golubkov; Alex Y Strongin
The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP).
Journal of cell science 2005;118(Pt 21):4975-84.
2005: Sergey Sikora; Alex Y Strongin; Adam Godzik
Convergent evolution as a mechanism for pathogenic adaptation.
Trends in microbiology 2005;13(11):522-7.
2005: Alexei Y Savinov; Dmitri V Rozanov; Vladislav Golubkov; F Susan Wong; Alex Y Strongin
Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.
The Journal of biological chemistry 2005;280(30):27755-8.
2005: Zezong Gu; Jiankun Cui; Stephen Brown; Rafael Fridman; Shahriar Mobashery; Alex Y Strongin; Stuart A Lipton
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6401-8.
2005: Martino Forino; Sherida Johnson; Thiang Y Wong; Dmitri V Rozanov; Alexei Y Savinov; Wei Li; Roberto Fattorusso; Barbara Becattini; Andrew J W Orry; Dawoon Jung; Ruben Abagyan; Jeffrey W Smith; Ken Alibek; Robert C Liddington; Alex Y Strongin; Surya De
Efficient synthetic inhibitors of anthrax lethal factor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9499-504.
2005: Vladislav Golubkov; Sarah Boyd; Alexei Y Savinov; Alexei V Chekanov; Andrei Osterman; Albert G Remacle; Dmitri V Rozanov; Stephen J Doxsey; Alex Y Strongin
Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability.
The Journal of biological chemistry 2005;280(26):25079-86.
2005: Priscilla Soulié; Fabio Carrozzino; Michael S Pepper; Alex Y Strongin; Marie-France Poupon; Roberto Montesano
Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.
Oncogene 2005;24(10):1689-97.
2005: Dmitri V Rozanov; Vladislav Golubkov; Alex Y Strongin
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
The international journal of biochemistry & cell biology 2005;37(1):142-54.
2004: Wei Li; Alexei Y Savinov; Dmitri V Rozanov; Vladislav Golubkov; Hirad Hedayat; Tatiana I Postnova; Natalia V Golubkova; Yu Linli; Stan Krajewski; Alex Y Strongin
Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin.
Cancer research 2004;64(23):8657-65.
2004: Robert N Weinreb; James D Lindsey; George N Marchenko; Natalia D Marchenko; Mila Angert; Alex Y Strongin
Prostaglandin FP agonists alter metalloproteinase gene expression in sclera.
Investigative ophthalmology & visual science 2004;45(12):4368-77.
2004: Dmitri V Rozanov; Sergey Sikora; Adam Godzik; Tatiana I Postnova; Vladislav Golubkov; Alexei Y Savinov; Stephen Tomlinson; Alex Y Strongin
Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q.
The Journal of biological chemistry 2004;279(48):50321-8.
2004: Dmitri V Rozanov; Alexei Y Savinov; Vladislav Golubkov; Tatiana I Postnova; Albert G Remacle; Stephen Tomlinson; Alex Y Strongin
Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system.
The Journal of biological chemistry 2004;279(45):46551-7.
2004: Alexey M Belkin; Evgeny A Zemskov; Jun Hang; Sergey S Akimov; Sergey Sikora; Alex Y Strongin
Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis.
Biochemistry 2004;43(37):11760-9.
2004: Elena I Deryugina; Boris I Ratnikov; Qing Yu; Peter C Baciu; Dmitri V Rozanov; Alex Y Strongin
Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells.
Traffic (Copenhagen, Denmark) 2004;5(8):627-41.
2004: Natalia D Marchenko; George N Marchenko; Robert N Weinreb; James D Lindsey; Ainura Kyshtoobayeva; Howard C Crawford; Alex Y Strongin
Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells.
The international journal of biochemistry & cell biology 2004;36(5):942-56.
2004: Dmitri V Rozanov; Elizabeth Hahn-Dantona; Dudley K Strickland; Alex Y Strongin
The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.
The Journal of biological chemistry 2004;279(6):4260-8.
2004: Dmitri V Rozanov; Elena I Deryugina; Edward Monosov; Natalia D Marchenko; Alex Y Strongin
Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells.
Experimental cell research 2004;293(1):81-95.
2004: Elena I Shagisultanova; Inna A Novikova; Yuri S Sidorenko; George N Marchenko; Alex Y Strongin; Sergei R Malkhosyan
The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer.
Anticancer research 2004;24(1):199-201.
2004: David Alonso-Escolano; Alex Y Strongin; Ada W Chung; Elena I Deryugina; Marek W Radomski
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins.
British journal of pharmacology 2004;141(2):241-52.
2003: Peter C Baciu; E Aisha Suleiman; Elena I Deryugina; Alex Y Strongin
Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells.
Experimental cell research 2003;291(1):167-75.
2003: George N Marchenko; Natalia D Marchenko; Alex Y Strongin
The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein.
The Biochemical journal 2003;372(Pt 2):503-15.
2003: Elena I Deryugina; Boris I Ratnikov; Alex Y Strongin
Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells.
International journal of cancer. Journal international du cancer 2003;104(5):533-41.
2003: Dmitri V Rozanov; Alex Y Strongin
Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms.
The Journal of biological chemistry 2003;278(10):8257-60.
2003: Katarina Wolf; Irina B Mazo; Harry Leung; Katharina Engelke; Ulrich H von Andrian; Elena I Deryugina; Alex Y Strongin; Eva-B Bröcker; Peter Friedl
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis.
The Journal of cell biology 2003;160(2):267-77.
2002: Boris I Ratnikov; Elena I Deryugina; Alex Y Strongin
Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase.
Laboratory investigation; a journal of technical methods and pathology 2002;82(11):1583-90.
2002: Dmitri V Rozanov; Berhane Ghebrehiwet; Boris I Ratnikov; Edward Monosov; Elena I Deryugina; Alex Y Strongin
The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein.
FEBS letters 2002;527(1-3):51-7.
2002: Zezong Gu; Marcus Kaul; Boxu Yan; Steven J Kridel; Jiankun Cui; Alex Y Strongin; Jeffrey W Smith; Robert C Liddington; Stuart A Lipton
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.
Science (New York, N.Y.) 2002;297(5584):1186-90.
2002: Steven J Kridel; Hisako Sawai; Boris I Ratnikov; Emily I Chen; Weizhong Li; Adam Godzik; Alex Y Strongin; Jeffrey W Smith
A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.
The Journal of biological chemistry 2002;277(26):23788-93.
2002: Natalia D Marchenko; George N Marchenko; Alex Y Strongin
Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif.
The Journal of biological chemistry 2002;277(21):18967-72.
2002: George N Marchenko; Natalia D Marchenko; Jay Leng; Alex Y Strongin
Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin.
The Biochemical journal 2002;363(Pt 2):253-62.
2002: Elena I Deryugina; Boris I Ratnikov; Tatiana I Postnova; Dmitri V Rozanov; Alex Y Strongin
Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase.
The Journal of biological chemistry 2002;277(12):9749-56.
2002: Dmitri V Rozanov; Berhane Ghebrehiwet; Tatiana I Postnova; Andreas Eichinger; Elena I Deryugina; Alex Y Strongin
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR.
The Journal of biological chemistry 2002;277(11):9318-25.
2002: Boris I Ratnikov; Dmitri V Rozanov; Tatiana I Postnova; Peter G Baciu; Heying Zhang; Richard G DiScipio; Galina G Chestukhina; Jeffrey W Smith; Elena I Deryugina; Alex Y Strongin
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase.
The Journal of biological chemistry 2002;277(9):7377-85.
2002: Elena I Deryugina; Liliana Soroceanu; Alex Y Strongin
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Cancer research 2002;62(2):580-8.
2001: Dmitri V Rozanov; Elena I Deryugina; Boris I Ratnikov; Edward Monosov; George N Marchenko; James P Quigley; Alex Y Strongin
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
The Journal of biological chemistry 2001;276(28):25705-14.
2001: George N Marchenko; Boris I Ratnikov; Dmitri V Rozanov; Adam Godzik; Elena I Deryugina; Alex Y Strongin
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin.
The Biochemical journal 2001;356(Pt 3):705-18.
2001: Alexey M Belkin; Sergey S Akimov; L S Zaritskaya; Boris I Ratnikov; Elena I Deryugina; Alex Y Strongin
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
The Journal of biological chemistry 2001;276(21):18415-22.
2001: George N Marchenko; Alex Y Strongin
MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors.
Gene 2001;265(1-2):87-93.
2001: Elena I Deryugina; Boris I Ratnikov; Edward Monosov; Tatiana I Postnova; Richard G DiScipio; Jeffrey W Smith; Alex Y Strongin
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells.
Experimental cell research 2001;263(2):209-23.
2000: B Ratnikov; Elena I Deryugina; J Leng; George N Marchenko; D Dembrow; Alex Y Strongin
Determination of matrix metalloproteinase activity using biotinylated gelatin.
Analytical biochemistry 2000;286(1):149-55.
2000: Elena I Deryugina; MA Bourdon; K Jungwirth; J W Smith; Alex Y Strongin
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.
International journal of cancer. Journal international du cancer 2000;86(1):15-23.
1998: Elena I Deryugina; MA Bourdon; RA Reisfeld; Alex Y Strongin
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
Cancer research 1998;58(16):3743-50.
1997: Elena I Deryugina; MA Bourdon; G X Luo; RA Reisfeld; Alex Y Strongin
Matrix metalloproteinase-2 activation modulates glioma cell migration.
Journal of cell science 1997;110 ( Pt 19)():2473-82.
1997: Elena I Deryugina; G X Luo; RA Reisfeld; MA Bourdon; Alex Y Strongin
Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.
Anticancer research 1997;17(5A):3201-10.
1996: Elena I Deryugina; Alex Y Strongin; C Yu; MA Bourdon
A novel monoclonal antibody, L1A3, is directed to the functional site of the alpha v integrin subunit.
Hybridoma 1996;15(4):279-88.