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Yu Wang

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Chao-Fan Liang; Jacky Tc Liu; Yu Wang; Aimin Xu; Paul M Vanhoutte
Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4.
Y C Woo; Aimin Xu; Yu Wang; Karen S L Lam
Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.
Bo Yang; Dewei Ye; Yu Wang
Caspase-3 as a therapeutic target for heart failure.

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All Publications

2013: Chao-Fan Liang; Jacky Tc Liu; Yu Wang; Aimin Xu; Paul M Vanhoutte
Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):777-84.
2013: Y C Woo; Aimin Xu; Yu Wang; Karen S L Lam
Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.
Clinical endocrinology 2013;78(4):489-96.
2013: Bo Yang; Dewei Ye; Yu Wang
Caspase-3 as a therapeutic target for heart failure.
Expert opinion on therapeutic targets 2013;17(3):255-63.
2013: Yuthika H Samaranayake; Yu Wang; J Y Y Yau; K W S Yeung; B P K Cheung; Lakshman Perera Samaranayake
Fluconazole resistance in Candida glabrata is associated with increased bud formation and metallothionein production.
Journal of medical microbiology 2013;62(Pt 2):303-18.
2013: Thanuja D K Herath; Chaminda J Seneviratne; Cun-Yu Wang; Yu Wang; Richard P Darveau; Lijian Jin
Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts.
PloS one 2013;8(3):e58496.
2013: Thanuja D K Herath; Chaminda J Seneviratne; Cun-Yu Wang; Yu Wang; Richard P Darveau; Lijian Jin
The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts.
BMC microbiology 2013;13():73.
2013: Bo Bai; Yu Wang
Methods to investigate the role of SIRT1 in endothelial senescence.
Methods in molecular biology (Clifton, N.J.) 2013;965():327-39.
2012: Yu Wang; Cheng Xu; Yan Liang; Paul M Vanhoutte
SIRT1 in metabolic syndrome: where to target matters.
Pharmacology & therapeutics 2012;136(3):305-18.
2012: Bo Bai; Mary Y K Lee; Yan Liang; Paul M Vanhoutte; Donghai Wu; Aimin Xu; Cheng Xu; Yu Wang
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis.
Circulation 2012;126(6):729-40.
2012: Mazdak Radjainia; Michael Schmitz; Yu Wang; Sung H Yang; Bo Bai; Margaret A Brimble; Michael D W Griffin; Paul W R Harris; Bosheng Huang; Alok K Mitra
A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin.
The FEBS journal 2012;279(14):2495-507.
2012: Dewei Ye; Weiping Jia; Karen S L Lam; Francois Y L Li; Huating Li; Xiaokun Li; Chung-Mau Lo; Kwan Man; Yu Wang; Aimin Xu
Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice.
Gut 2012;61(7):1058-67.
2012: Kenneth K Y Cheng; Ruby L C Hoo; Karen S L Lam; Gary Sweeney; Yu Wang; Donghai Wu; Jialiang Zhang; Aimin Xu
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):8919-24.
2012: C Jayampath Seneviratne; Yu Wang; Sarah S W Wong; Thanuja D K Herath; LJ Jin; Lakshman P Samaranayake
Unraveling the resistance of microbial biofilms: has proteomics been helpful?
Proteomics 2012;12(4-5):651-65.
2012: Mingyan Zhou; Donghai Wu; Aimin Xu; Bosheng Huang; Karen S L Lam; In-Kyu Lee; Yan Liang; Paul K H Tam; Yu Wang
Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K.
PloS one 2012;7(2):e32349.
2011: Zhuoming Li; Yu Wang; Paul M Vanhoutte
Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.
Hypertension 2011;58(5):926-34.
2011: Priscilla T Y Leung; Sarah S T Mak; W C Ng; Yu Wang; Kenneth M Y Leung
Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide.
Aquatic toxicology (Amsterdam, Netherlands) 2011;105(1-2):49-61.
2011: Garry A Williams; Karen E Callon; Jessica L Costa; Michelle Dickinson; Yaoyao Ding; Dorit Naot; Ian R Reid; Yu Wang; Maureen Watson; Jillian Cornish
Skeletal phenotype of the leptin receptor-deficient db/db mouse.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(8):1698-709.
2011: Zhuoming Li; Yu Wang; Paul M Vanhoutte
Epigallocatechin gallate elicits contractions of the isolated aorta of the aged spontaneously hypertensive rat.
Basic & clinical pharmacology & toxicology 2011;109(1):47-55.
2011: Yu Wang; Yan Liang; Paul M Vanhoutte
SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model.
FEBS letters 2011;585(7):986-94.
2010: Mingyan Zhou; Aimin Xu; Karen S L Lam; Paul K H Tam; Chi-Ming Che; Lawrence Chan; In-kyu Lee; Donghai Wu; Yu Wang
Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin.
Journal of hepatology 2010;53(6):1108-16.
2010: Yi Zu; Ling Liu; Mary Y K Lee; Cheng Xu; Yan Liang; Ricky Y Man; Paul M Vanhoutte; Yu Wang
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.
Circulation research 2010;106(8):1384-93.
2010: Jayampath Seneviratne; Yu Wang; LJ Jin; Y Abiko; Lakshman P Samaranayake
Proteomics of drug resistance in Candida glabrata biofilms.
Proteomics 2010;10(7):1444-54.
2010: Bo Bai; Yu Wang
The use of lorcaserin in the management of obesity: a critical appraisal.
Drug design, development and therapy 2010;5():1-7.
2010: Aimin Xu; Yu Wang; Karen S L Lam; Paul M Vanhoutte
Vascular actions of adipokines molecular mechanisms and therapeutic implications.
Advances in pharmacology (San Diego, Calif.) 2010;60():229-55.
2010: Mary Y K Lee; Yu Wang; Paul M Vanhoutte
Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB.
Journal of vascular research 2010;47(4):287-98.
2010: Kim Hei-Man Chow; Raymond Wai-Yin Sun; Janice B B Lam; Carrie Ka-Lei Li; Aimin Xu; Dik-Lung Ma; Ruben Abagyan; Yu Wang; Chi-Ming Che
A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway.
Cancer research 2010;70(1):329-37.
2010: Yu Wang; Juan Li; C Ying Wang; A Yan Kwok; X Zhang; Frederick C C Leung
Characterization of the receptors for chicken GHRH and GHRH-related peptides: identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP).
Domestic animal endocrinology 2010;38(1):13-31.
2009: Garry A Williams; Yu Wang; Karen E Callon; Maureen Watson; Jian-ming Lin; Janice B B Lam; Jessica L Costa; Ajay Orpe; Neil D Broom; Dorit Naot; Ian R Reid; Jillian Cornish
In vitro and in vivo effects of adiponectin on bone.
Endocrinology 2009;150(8):3603-10.
2009: Dennis C Y Yeung; Karen S L Lam; Yu Wang; Annette W K Tso; Aimin Xu
Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects.
The Journal of clinical endocrinology and metabolism 2009;94(7):2531-6.
2009: Kenneth K Y Cheng; Miguel A Iglesias; Karen S L Lam; Yu Wang; Gary Sweeney; Weidong Zhu; Paul M Vanhoutte; Edward W Kraegen; Aimin Xu
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
Cell metabolism 2009;9(5):417-27.
2009: Ivy K M Law; Ling Liu; Aimin Xu; Karen S L Lam; Paul M Vanhoutte; Chi-Ming Che; Priscilla T Y Leung; Yu Wang
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
Proteomics 2009;9(9):2444-56.
2009: Ming-Hon Yau; Yu Wang; Karen S L Lam; Jialiang Zhang; Donghai Wu; Aimin Xu
A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.
The Journal of biological chemistry 2009;284(18):11942-52.
2009: Yu Wang; Mingyan Zhou; Karen S L Lam; Aimin Xu
Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.
Arquivos brasileiros de endocrinologia e metabologia 2009;53(2):201-12.
2009: Aimin Xu; Hongbing Wang; Ruby L C Hoo; Gary Sweeney; Paul M Vanhoutte; Yu Wang; Donghai Wu; Wenjing Chu; Guowei Qin; Karen S L Lam
Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice.
Endocrinology 2009;150(2):625-33.
2009: Janice B B Lam; Kim H M Chow; Aimin Xu; Karen S L Lam; Jing Liu; Nai-Sum Wong; Randall T Moon; Peter R Shepherd; Garth J S Cooper; Yu Wang
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
PloS one 2009;4(3):e4968.
2008: Jing Liu; Janice B B Lam; Kim H M Chow; Aimin Xu; Karen S L Lam; Randall T Moon; Yu Wang
Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.
Carcinogenesis 2008;29(11):2195-202.
2008: Mingyan Zhou; Aimin Xu; Paul K H Tam; Karen S L Lam; Lawrence Chan; Ruby L C Hoo; Jing Liu; Kim H M Chow; Yu Wang
Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury.
Hepatology (Baltimore, Md.) 2008;48(4):1087-96.
2008: Dennis C Y Yeung; Yu Wang; Aimin Xu; Stephen C W Cheung; Nelson M S Wat; Daniel Y T Fong; Carol H Y Fong; Ming Tak Chau; Pak C Sham; Karen S L Lam
Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis.
European heart journal 2008;29(17):2156-63.
2008: Mazdak Radjainia; Yu Wang; Alok K Mitra
Structural polymorphism of oligomeric adiponectin visualized by electron microscopy.
Journal of molecular biology 2008;381(2):419-30.
2008: Jayampath Seneviratne; Yu Wang; LJ Jin; Yoshi Abiko; Lakshman Perera Samaranayake
Candida albicans biofilm formation is associated with increased anti-oxidative capacities.
Proteomics 2008;8(14):2936-47.
2008: Ling Liu; Yu Wang; Karen S L Lam; Aimin Xu
Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications.
Endocrine, metabolic & immune disorders drug targets 2008;8(2):89-98.
2008: Ying-Hua Yang; Yu Wang; Karen S L Lam; Ming-Hon Yau; Kenneth K Y Cheng; Jialiang Zhang; Weidong Zhu; Donghai Wu; Aimin Xu
Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):835-40.
2008: Sally D Poppitt; Geraldine Keogh; Fiona E Lithander; Yu Wang; Tom B Mulvey; Yih-Kai Chan; Brian H McArdle; Garth J S Cooper
Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load.
Nutrition (Burbank, Los Angeles County, Calif.) 2008;24(4):322-9.
2008: Fiona E Lithander; Geraldine Keogh; Yu Wang; Garth J S Cooper; Tom B Mulvey; Yih-Kai Chan; Brian H McArdle; Sally D Poppitt
No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks.
Obesity (Silver Spring, Md.) 2008;16(3):592-9.
2008: Yu Wang; Karen S L Lam; Ming-hon Yau; Aimin Xu
Post-translational modifications of adiponectin: mechanisms and functional implications.
The Biochemical journal 2008;409(3):623-33.
2008: Shiu-Cheung Lung; Andy Leung; Rainbow Kuang; Yu Wang; Priscilla Leung; Boon L Lim
Phytase activity in tobacco (Nicotiana tabacum) root exudates is exhibited by a purple acid phosphatase.
Phytochemistry 2008;69(2):365-73.
2007: Annette W K Tso; Aimin Xu; Pak C Sham; Nelson M S Wat; Yu Wang; Carol H Y Fong; Bernard M Y Cheung; Edward D Janus; Karen S L Lam
Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort.
Diabetes care 2007;30(10):2667-72.
2007: Kar Keung Cheng; Karen S L Lam; Yu Wang; Yu Huang; David Carling; Donghai Wu; Chiwai Wong; Aimin Xu
Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells.
Diabetes 2007;56(5):1387-94.
2007: Mia Jüllig; Xiuyin Chen; Anthony J Hickey; David J Crossman; Aimin Xu; Yu Wang; David R Greenwood; Yee Soon Choong; Sarah J Schönberger; Martin J Middleditch; Anthony R J Phillips; Garth J S Cooper
Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator.
Proteomics. Clinical applications 2007;1(4):387-99.
2007: Yu Wang; Karen S L Lam; Aimin Xu
Adiponectin as a negative regulator in obesity-related mammary carcinogenesis.
Cell research 2007;17(4):280-2.
2007: Yu Wang; Karen S L Lam; Janice B B Lam; Michael C Lam; Priscilla T Y Leung; Mingyan Zhou; Aimin Xu
Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice.
Molecular endocrinology (Baltimore, Md.) 2007;21(4):972-86.
2007: Aimin Xu; Annette W K Tso; Bernard M Y Cheung; Yu Wang; Nelson M S Wat; Carol H Y Fong; Dennis Yeung; Edward D Janus; Pak C Sham; Karen S L Lam
Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study.
Circulation 2007;115(12):1537-43.
2007: Yu Wang; Karen S L Lam; Edward W Kraegen; Gary Sweeney; Jialiang Zhang; Annette W K Tso; Wing-Sun Chow; Nelson M S Wat; Jian Yu Xu; Ruby L C Hoo; Aimin Xu
Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.
Clinical chemistry 2007;53(1):34-41.
2006: Yu Wang; Janice B B Lam; Karen S L Lam; Jing Liu; Michael C Lam; Ruby L C Hoo; Donghai Wu; Garth J S Cooper; Aimin Xu
Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.
Cancer research 2006;66(23):11462-70.
2006: Yu Wang; Lance Yi Xu; Karen S L Lam; Gang Lu; Garth J S Cooper; Aimin Xu
Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin.
Proteomics 2006;6(13):3862-70.
2006: Yu Wang; Karen S L Lam; Lawrence Chan; Kok Weng Chan; Janice B B Lam; Michael C Lam; Ruby C L Hoo; William W N Mak; Garth J S Cooper; Aimin Xu
Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex.
The Journal of biological chemistry 2006;281(24):16391-400.
2006: Baoying Chen; Karen S L Lam; Yu Wang; Donghai Wu; Michael C Lam; Jiangang Shen; Laiching Wong; Ruby L C Hoo; Jialiang Zhang; Aimin Xu
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes.
Biochemical and biophysical research communications 2006;341(2):549-56.
2006: Aimin Xu; Yu Wang; Jian Yu Xu; David Stejskal; Sidney Tam; Jialiang Zhang; Nelson M S Wat; Wai Keung Wong; Karen S L Lam
Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome.
Clinical chemistry 2006;52(3):405-13.
2005: Yu Wang; Ben C B Ko; James Y Yang; Terrence T L Lam; Zhirong Jiang; Jinsong Zhang; Sookja K Chung; Stephen S M Chung
Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.
The Journal of biological chemistry 2005;280(20):19986-91.
2005: Aimin Xu; Kok Weng Chan; Ruby L C Hoo; Yu Wang; Kathryn C B Tan; Jialiang Zhang; Baoying Chen; Michael C Lam; Cynthia Tse; Garth J S Cooper; Karen S L Lam
Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes.
The Journal of biological chemistry 2005;280(18):18073-80.
2005: Yu Wang; Karen S L Lam; Jian Yu Xu; Gang Lu; Lance Yi Xu; Garth J S Cooper; Aimin Xu
Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.
The Journal of biological chemistry 2005;280(18):18341-7.
2005: Aimin Xu; Michael C Lam; Kok Weng Chan; Yu Wang; Jialiang Zhang; Ruby L C Hoo; Jian Yu Xu; Baoying Chen; Wing-Sun Chow; Annette W K Tso; Karen S L Lam
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6086-91.
2004: Yu Wang; Gang Lu; Winifred P S Wong; Johannes Vliegenthart; Gerrit J Gerwig; Karen S L Lam; Garth J S Cooper; Aimin Xu
Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum.
Proteomics 2004;4(12):3933-42.
2004: Aimin Xu; Lai Ching Wong; Yu Wang; Jian Yu Xu; Garth J S Cooper; Karen S L Lam
Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.
FEBS letters 2004;572(1-3):129-34.
2004: Kai-Luk Choi; Yu Wang; Cynthia A Tse; Karen S L Lam; Garth J S Cooper; Aimin Xu
Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes.
Proteomics 2004;4(6):1840-8.
2003: Aimin Xu; Yu Wang; Hussila Keshaw; Lance Yi Xu; Karen S L Lam; Garth J S Cooper
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice.
The Journal of clinical investigation 2003;112(1):91-100.
2002: Yu Wang; Aimin Xu; Catriona Knight; Lance Yi Xu; Garth J S Cooper
Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity.
The Journal of biological chemistry 2002;277(22):19521-9.
2002: Aimin Xu; Kai-Luk Choi; Yu Wang; Paska A Permana; Lance Yi Xu; Clifton Bogardus; Garth J S Cooper
Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells.
Biochemical and biophysical research communications 2002;293(4):1161-7.
2001: Yu Wang; Aimin Xu; J Ye; Edward W Kraegen; Cynthia A Tse; G J Cooper
Alteration in phosphorylation of P20 is associated with insulin resistance.
Diabetes 2001;50(8):1821-7.
2001: Aimin Xu; Yu Wang; Lance Yi Xu; R Stewart Gilmour
Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells.
The Journal of biological chemistry 2001;276(18):14980-6.
1999: Yu Wang; Aimin Xu; G J Cooper
Phosphorylation of P20 is associated with the actions of insulin in rat skeletal and smooth muscle.
The Biochemical journal 1999;344 Pt 3():971-6.
1999: Yu Wang; Aimin Xu; Richard B Pearson; G J Cooper
Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle.
FEBS letters 1999;462(1-2):25-30.
1999: Yu Wang; Aimin Xu; G J Cooper
Amylin evokes phosphorylation of P20 in rat skeletal muscle.
FEBS letters 1999;457(1):149-52.