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Clinton Bruce

Research Profile

Anatomy

Muscle, Skeletal

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G I Lancaster; K G Langley; H T Nicholls; G W Rewcastle; P R Shepherd; B Skiba; C Yang; Clinton R Bruce; M H S Chan; M Karin; M A Febbraio
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
James Boon; Russell D Brown; Clinton R Bruce; Darren C Henstridge; Jeffrey F Horowitz; Andrew J Hoy; Bronwyn A Kingwell; Ruth C Meex; Peter J Meikle; Simon Schenk; Romana Stark; Matthew J Watt
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.
Clinton R Bruce; Joanne R Babb; Darren C Henstridge; Robert S Lee-Young; Steve Risis; Christine Yang; Mark A Febbraio
The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice.

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2013: G I Lancaster; K G Langley; H T Nicholls; G W Rewcastle; P R Shepherd; B Skiba; C Yang; Clinton R Bruce; M H S Chan; M Karin; M A Febbraio
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
The Biochemical journal 2013;452(1):171.
2013: James Boon; Russell D Brown; Clinton R Bruce; Darren C Henstridge; Jeffrey F Horowitz; Andrew J Hoy; Bronwyn A Kingwell; Ruth C Meex; Peter J Meikle; Simon Schenk; Romana Stark; Matthew J Watt
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.
Diabetes 2013;62(2):401-10.
2013: Clinton R Bruce; Joanne R Babb; Darren C Henstridge; Robert S Lee-Young; Steve Risis; Christine Yang; Mark A Febbraio
The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice.
Endocrinology 2013;154(1):65-76.
2012: Clinton R Bruce; Joanne R Babb; Greg M Kowalski; Robert S Lee-Young; Peter J Meikle; Stuart M Pitson; Steve Risis; Ahrathy Selathurai; Yoh Takuwa; Jacquelyn M Weir; Christine Yang; Kazuaki Yoshioka; Mark A Febbraio
Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.
Diabetes 2012;61(12):3148-55.
2012: Matthew J Watt; S Schenk; A C Barnett; Clinton R Bruce; J F Horowitz; A J Hoy
Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.
Diabetologia 2012;55(10):2741-6.
2012: D C Henstridge; K S L Lam; G I Lancaster; P J Meikle; C P Pang; J M Weir; A Xu; T L Allen; Clinton R Bruce; E Estevez; N Fujii; T Gardner; L J Goodyear; Mark A Febbraio
Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice.
Diabetologia 2012;55(10):2769-78.
2012: Graeme I Lancaster; Katherine G Langley; Hayley T Nicholls; Gordon W Rewcastle; Peter R Shepherd; Beata Skiba; Christine Yang; Clinton R Bruce; M H Stanley Chan; Michael Karin; Mark A Febbraio
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
The Biochemical journal 2012;442(3):723-32.
2012: Melissa N Barber; Mark A Febbraio; Peter J Meikle; Steve Risis; Margaret Staples; Christine Yang; Clinton R Bruce
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes.
PloS one 2012;7(7):e41456.
2011: G M Kowalski; H T Nicholls; S Risis; N K Watson; P Kanellakis; Clinton R Bruce; A Bobik; G I Lancaster; M A Febbraio
Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice.
Diabetologia 2011;54(4):888-99.
2010: V B Matthews; T L Allen; S Risis; M H S Chan; D C Henstridge; N Watson; L A Zaffino; J R Babb; J Boon; P J Meikle; J B Jowett; Matthew J Watt; J-O Jansson; Clinton R Bruce; Mark A Febbraio
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance.
Diabetologia 2010;53(11):2431-41.
2010: Todd W Mitchell; Nigel Turner; Paul L Else; Anthony J Hulbert; John A Hawley; Jong Sam Lee; Clinton R Bruce; Stephen J Blanksby
The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet.
International journal of molecular sciences 2010;11(10):3954-64.
2009: V B Matthews; M-B Aström; M H S Chan; Clinton R Bruce; K S Krabbe; Oja Prelovsek; T Akerström; C Yfanti; C Broholm; Ole Hartvig Mortensen; Milena Penkowa; Pernille Hojman; A Zankari; Matthew J Watt; H Bruunsgaard; Bente Klarlund Pedersen; Mark A Febbraio
Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase.
Diabetologia 2009;52(7):1409-18.
2009: Andrew J Hoy; Amanda E Brandon; Nigel Turner; Matthew J Watt; Clinton R Bruce; Gregory J Cooney; Edward W Kraegen
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E67-75.
2009: Clinton R Bruce; Andrew J Hoy; Nigel Turner; Matthew J Watt; Tamara L Allen; Kevin Carpenter; Gregory J Cooney; Mark A Febbraio; Edward W Kraegen
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.
Diabetes 2009;58(3):550-8.
2009: Shinji Miura; Yuko Kai; Yasutomi Kamei; Clinton R Bruce; Naoto Kubota; Mark A Febbraio; Takashi Kadowaki; Osamu Ezaki
Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise.
American journal of physiology. Endocrinology and metabolism 2009;296(1):E47-55.
2008: Anna G Holmes; Jose L Mesa; Bronwyn A Neill; Jason Chung; Andrew L Carey; Gregory R Steinberg; Bruce E Kemp; Robert J Southgate; Graeme I Lancaster; Clinton R Bruce; Matthew J Watt; Mark A Febbraio
Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats.
The Journal of endocrinology 2008;198(2):367-74.
2008: Matthew J Watt; Bryce J W van Denderen; Laura A Castelli; Clinton R Bruce; Andrew J Hoy; Edward W Kraegen; Lance Macaulay; Bruce E Kemp
Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness.
Molecular endocrinology (Baltimore, Md.) 2008;22(5):1200-12.
2008: Jason Chung; Anh-Khoi Nguyen; Darren C Henstridge; Anna G Holmes; M H Stanley Chan; Jose L Mesa; Graeme I Lancaster; Robert J Southgate; Clinton R Bruce; Stephen J Duffy; Ibolya Horvath; Ruben Mestril; Matthew J Watt; Philip L Hooper; Bronwyn A Kingwell; László Vigh; Andrea L Hevener; Mark A Febbraio
HSP72 protects against obesity-induced insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1739-44.
2007: Andrew J Hoy; Clinton R Bruce; Anna Cederberg; Nigel Turner; David E James; Gregory J Cooney; Edward W Kraegen
Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation.
American journal of physiology. Endocrinology and metabolism 2007;293(5):E1358-64.
2007: Clinton R Bruce; Mark A Febbraio
It's what you do with the fat that matters!
Nature medicine 2007;13(10):1137-8.
2007: Nigel Turner; Clinton R Bruce; Susan M Beale; Kyle Hoehn; Trina So; Michael S Rolph; Gregory J Cooney
Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.
Diabetes 2007;56(8):2085-92.
2007: Clinton R Bruce; Camilla Brolin; Nigel Turner; Mark E Cleasby; Feike R van der Leij; Gregory J Cooney; Edward W Kraegen
Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification.
American journal of physiology. Endocrinology and metabolism 2007;292(4):E1231-7.
2006: Cheryl A Collier; Clinton R Bruce; Angela C Smith; Gary D Lopaschuk; David J Dyck
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E182-9.
2006: Clinton R Bruce; A Brianne Thrush; Valerie A Mertz; Veronic Bezaire; Adrian Chabowski; George J F Heigenhauser; David J Dyck
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content.
American journal of physiology. Endocrinology and metabolism 2006;291(1):E99-E107.
2006: Andrew L Carey; E Wolsk Petersen; Clinton R Bruce; Robert J Southgate; H Pilegaard; J A Hawley; Bente Klarlund Pedersen; Mark A Febbraio
Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.
Diabetologia 2006;49(5):1000-7.
2006: Veronic Bezaire; Clinton R Bruce; George J F Heigenhauser; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; Arend Bonen; Lawrence L Spriet
Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation.
American journal of physiology. Endocrinology and metabolism 2006;290(3):E509-15.
2006: David J Dyck; George J F Heigenhauser; Clinton R Bruce
The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.
Acta physiologica (Oxford, England) 2006;186(1):5-16.
2005: Robert J Southgate; Clinton R Bruce; Andrew L Carey; Gregory R Steinberg; Ken Walder; Robert Monks; Matthew J Watt; John A Hawley; Morris J Birnbaum; Mark A Febbraio
PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2072-4.
2005: Clinton R Bruce; Valerie A Mertz; George J F Heigenhauser; David J Dyck
The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects.
Diabetes 2005;54(11):3154-60.
2005: Angela C Smith; Clinton R Bruce; David J Dyck
AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle.
The Journal of physiology 2005;565(Pt 2):537-46.
2005: Angela C Smith; Clinton R Bruce; David J Dyck
AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle.
The Journal of physiology 2005;565(Pt 2):547-53.
2004: Melissa J Arkinstall; Clinton R Bruce; Sally A Clark; Caroline A Rickards; Louise Mary Burke; John A Hawley
Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(6):2275-83.
2004: Todd W Mitchell; Nigel Turner; Anthony J Hulbert; Paul L Else; John A Hawley; Jong Sam Lee; Clinton R Bruce; Stephen J Blanksby
Exercise alters the profile of phospholipid molecular species in rat skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(5):1823-9.
2004: Clinton R Bruce; David J Dyck
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E616-21.
2004: Clinton R Bruce; Jong Sam Lee; Bente Kiens; John A Hawley
Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats.
Obesity research 2004;12(7):1158-65.
2004: Clinton R Bruce; John A Hawley
Improvements in insulin resistance with aerobic exercise training: a lipocentric approach.
Medicine and science in sports and exercise 2004;36(7):1196-201.
2004: Andrew L Carey; Clinton R Bruce; M Sacchetti; M J Anderson; D B Olsen; Bengt Saltin; J A Hawley; Mark A Febbraio
Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness.
Diabetologia 2004;47(6):1029-37.
2004: Glenn D Wadley; Clinton R Bruce; Nicky Konstantopoulos; S Lance Macaulay; Kirsten F Howlett; John A Hawley; David Cameron-Smith
The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.
Diabetologia 2004;47(3):412-9.
2004: Nigel Turner; Jong Sam Lee; Clinton R Bruce; Todd W Mitchell; Paul L Else; Anthony J Hulbert; John A Hawley
Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(3):974-80.
2004: Clinton R Bruce; Adamandia D Kriketos; Gregory J Cooney; John A Hawley
Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.
Diabetologia 2004;47(1):23-30.
2003: Andrew J McAinch; Jong-Sam Lee; Clinton R Bruce; Rebecca J Tunstall; John A Hawley; David Cameron-Smith
Dietary regulation of fat oxidative gene expression in different skeletal muscle fiber types.
Obesity research 2003;11(12):1471-9.
2003: Clinton R Bruce; Mitchell J Anderson; Andrew L Carey; David G Newman; Arend Bonen; Adamandia D Kriketos; Gregory J Cooney; John A Hawley
Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status.
The Journal of clinical endocrinology and metabolism 2003;88(11):5444-51.
2003: Clinton R Bruce; Andrew L Carey; John A Hawley; Mark A Febbraio
Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.
Diabetes 2003;52(9):2338-45.
2002: Gregory R Cox; Ben Desbrow; Paul G Montgomery; Megan Anderson; Clinton R Bruce; Theodore A Macrides; David T Martin; Angela Moquin; Alan Roberts; John A Hawley; Louise Mary Burke
Effect of different protocols of caffeine intake on metabolism and endurance performance.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(3):990-9.
2002: Jong Sam Lee; Clinton R Bruce; Brian E Spurrell; John A Hawley
Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle.
Clinical and experimental pharmacology & physiology 2002;29(8):655-60.
2002: J S Lee; Clinton R Bruce; Rebecca J Tunstall; David Cameron-Smith; H Hugel; John A Hawley
Interaction of exercise and diet on GLUT-4 protein and gene expression in Type I and Type II rat skeletal muscle.
Acta physiologica Scandinavica 2002;175(1):37-44.
2001: Melissa J Arkinstall; Clinton R Bruce; Vasilis Nikolopoulos; A P Garnham; John A Hawley
Effect of carbohydrate ingestion on metabolism during running and cycling.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2125-34.
2001: Clinton R Bruce; J S Lee; John A Hawley
Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(4):1512-9.
2001: J S Lee; Clinton R Bruce; Lawrence L Spriet; John A Hawley
Interaction of diet and training on endurance performance in rats.
Experimental physiology 2001;86(4):499-508.