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Michael Tweedle

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Ajay Shrivastava; Haiming Ding; Izabela Gierach; Natarajan Raju; Shu-Huei Wang; Michael Tweedle
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
Karen Linder; Edmund Marinelli; Edmund Metcalfe; Palaniappa Nanjappan; Adrian D Nunn; Kimberly Ramos; Tina Marie Skedzielewski; Thangavel Arunachalam; Michael Tweedle; Rolf E Swenson
Synthesis, in vitro evaluation, and in vivo metabolism of fluor/quencher compounds containing IRDye 800CW and Black Hole Quencher-3 (BHQ-3).
John N Morelli; Val M. Runge; Jonathon M Williams; Robert S Beissner; Michael Tweedle
Evaluation of a fibrin-binding gadolinium chelate peptide tetramer in a brain glioma model.

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All Publications

2013: Ajay Shrivastava; Haiming Ding; Izabela Gierach; Natarajan Raju; Shu-Huei Wang; Michael Tweedle
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
Bioorganic & medicinal chemistry letters 2013;23(3):687-92.
2011: Karen Linder; Edmund Marinelli; Edmund Metcalfe; Palaniappa Nanjappan; Adrian D Nunn; Kimberly Ramos; Tina Marie Skedzielewski; Thangavel Arunachalam; Michael Tweedle; Rolf E Swenson
Synthesis, in vitro evaluation, and in vivo metabolism of fluor/quencher compounds containing IRDye 800CW and Black Hole Quencher-3 (BHQ-3).
Bioconjugate chemistry 2011;22(7):1287-97.
2011: John N Morelli; Val M. Runge; Jonathon M Williams; Robert S Beissner; Michael Tweedle
Evaluation of a fibrin-binding gadolinium chelate peptide tetramer in a brain glioma model.
Investigative radiology 2011;46(3):169-77.
2009: Mary Ellen Maddalena; Jaclyn Fox; Jianqing Chen; Weiwei Feng; Aldo Cagnolini; Karen Linder; Michael Tweedle; Adrian Nunn; Laura E Lantry
177Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(12):2017-24.
2009: Michael Tweedle
Peptide-targeted diagnostics and radiotherapeutics.
Accounts of chemical research 2009;42(7):958-68.
2009: Bernd Wintersperger; Val M. Runge; Michael Tweedle; Carney B Jackson; Maximilian F Reiser
Brain tumor enhancement in magnetic resonance imaging: dependency on the level of protein binding of applied contrast agents.
Investigative radiology 2009;44(2):89-94.
2009: A Shrivastava; A D Nunn; Michael Tweedle
Designer peptides: learning from nature.
Current pharmaceutical design 2009;15(6):675-81.
2008: Jianqing Chen; Karen Linder; Aldo Cagnolini; Edmund Metcalfe; Natarajan Raju; Michael Tweedle; Rolf E Swenson
Synthesis, stabilization and formulation of [177Lu]Lu-AMBA, a systemic radiotherapeutic agent for Gastrin Releasing Peptide receptor positive tumors.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2008;66(4):497-505.
2007: Michael Tweedle
"Stability" of gadolinium chelates.
The British journal of radiology 2007;80(955):583-4; author reply 584-5.
2007: Mathew A von Wronski; Michael Tweedle; Adrian Nunn
Binding of the C-terminal amino acids of VEGF121 directly with neuropilin-1 should be considered.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1292; author reply 1293.
2006: Laura E Lantry; Enrico Cappelletti; Mary Ellen Maddalena; Jaclyn S Fox; Weiwei Feng; Jianqing Chen; Regi Thomas; Stephen M Eaton; Nancy J Bogdan; Thangavel Arunachalam; Jean Claude Reubi; Natarajan Raju; Edmund C Metcalfe; Luciano Lattuada; Karen Linder; Rolf E Swenson; Michael Tweedle; Adrian Nunn
177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(7):1144-52.
2006: Mathew A von Wronski; Natarajan Raju; Radhakrishna Pillai; Nancy J Bogdan; Edmund Marinelli; Palaniappa Nanjappan; Kondareddiar Ramalingam; Thangavel Arunachalam; Steve Eaton; Karen Linder; Feng Yan; Sibylle Pochon; Michael Tweedle; Adrian Nunn
Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor.
The Journal of biological chemistry 2006;281(9):5702-10.
2006: Gregory W White; Wendell A Gibby; Michael Tweedle
Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.
Investigative radiology 2006;41(3):272-8.
2006: Michael Tweedle
Adventures in multivalency, the Harry S. Fischer memorial lecture CMR 2005; Evian, France.
Contrast media & molecular imaging 2006;1(1):2-9.
2005: A Shrivastava; Mathew A von Wronski; A K Sato; Daniel T Dransfield; D Sexton; Nancy J Bogdan; Radhakrishna Pillai; Palaniappa Nanjappan; Bo Song; Edmund Marinelli; Daniel B DeOliveira; C Luneau; Mary Devlin; Arumugam Muruganandam; A Abujoub; G Connelly; Q L Wu; Greg Conley; Q Chang; Michael Tweedle; Robert C Ladner; Rolf E Swenson; Adrian Nunn
A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases.
Protein engineering, design & selection : PEDS 2005;18(9):417-24.
2002: Ramachandran S Ranganathan; Natarajan Raju; Helen Fan; Xun Zhang; Michael Tweedle; Jean F Desreux; Vincent Jacques
Polymethylated DOTA ligands. 2. Synthesis of rigidified lanthanide chelates and studies on the effect of alkyl substitution on conformational mobility and relaxivity.
Inorganic chemistry 2002;41(25):6856-66.
2002: Ramachandran S Ranganathan; Radhakrishna K Pillai; Natarajan Raju; Helen Fan; Hanh Nguyen; Michael Tweedle; Jean F Desreux; Vincent Jacques
Polymethylated DOTA ligands. 1. Synthesis of rigidified ligands and studies on the effects of alkyl substitution on acid-base properties and conformational mobility.
Inorganic chemistry 2002;41(25):6846-55.
2002: Edmund Marinelli; Richard Neubeck; Bo Song; Thomas Wagler; Ramachandran S Ranganathan; Kozikhott Sukumaran; PW Wedeking; Adrian Nunn; V Runge; Michael Tweedle
Synthesis and evaluation of macrocyclic gadolinium chelates as hepatospecific MRI agents.
Academic radiology 2002;9 Suppl 1():S251-4.
2002: Michael Tweedle
Using radiotracers to characterize magnetic resonance imaging contrast agents.
Investigative radiology 2002;37(3):107-13.
2000: Phillip Williams; G L Anderson; J L Johnstone; Adrian Nunn; Michael Tweedle; PW Wedeking
Caenorhabditis elegans as an alternative animal species.
Journal of toxicology and environmental health. Part A 2000;61(8):641-7.
2000: Edmund Marinelli; R Neubeck; Bo Song; T Wagler; Ramachandran S Ranganathan; K Sukumaran; PW Wedeking; Adrian Nunn; Val M. Runge; Michael Tweedle
Synthesis, characterization, and imaging performance of a new class of macrocyclic hepatobiliary MR contrast agents.
Investigative radiology 2000;35(1):8-24.
1999: PW Wedeking; R Shukla; Y T Kouch; Adrian Nunn; Michael Tweedle
Utilization of the nephrectomized mouse for determining threshold effects of MRI contrast agents.
Magnetic resonance imaging 1999;17(4):569-75.
1998: Ramachandran S Ranganathan; M E Fernandez; S I Kang; Adrian Nunn; P C Ratsep; K M Pillai; X Zhang; Michael Tweedle
New multimeric magnetic resonance imaging agents.
Investigative radiology 1998;33(11):779-97.
1998: Ramachandran S Ranganathan; T Arunachalam; Bo Song; S Mantha; M Ogan; PW Wedeking; F Yost; E Jagoda; Michael Tweedle
Evaluation of N,N'-bis-dimethyldiatrizoic acid analogs as liver imaging agents.
Academic radiology 1998;5 Suppl 1():S23-7.
1997: Michael Tweedle; X Zhang; M Fernandez; PW Wedeking; Adrian Nunn; Harry W Strauss
A noninvasive method for monitoring renal status at bedside.
Investigative radiology 1997;32(12):802-5.
1997: Adrian Nunn; Karen Linder; Michael Tweedle
Can receptors be imaged with MRI agents?
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):155-62.
1997: Michael Tweedle
The ProHance story: the making of a novel MRI contrast agent.
European radiology 1997;7 Suppl 5():225-30.
1997: R B Shukla; K Kumar; R Weber; X Zhang; Michael Tweedle
Alteration of electronic relaxation in MR contrast agents through de-novo ligand design.
Acta radiologica. Supplementum 1997;412():121-3.
1996: Adrian Nunn; PW Wedeking; E Marinelli; Ramachandran S Ranganathan; K Kumar; R Pillai; Michael Tweedle
Toxicity of gadolinium chelates in rodents.
Academic radiology 1996;3 Suppl 2():S333-5.
1996: R Shukla; M Fernandez; R K Pillai; Ramachandran S Ranganathan; P C Ratsep; X Zhang; Michael Tweedle
Design of conformationally rigid dimeric MRI agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;35(6):928-31.
1995: Michael Tweedle; PW Wedeking; K Kumar
Biodistribution of radiolabeled, formulated gadopentetate, gadoteridol, gadoterate, and gadodiamide in mice and rats.
Investigative radiology 1995;30(6):372-80.
1995: X Wan; PW Wedeking; Michael Tweedle
MRI evaluation of potential gastrointestinal contrast media.
Magnetic resonance imaging 1995;13(2):215-8.
1994: X Zhang; R Pillai; R Shukla; Ramachandran S Ranganathan; Michael Tweedle
New aromatic macrocyclic gadolinium chelates with enhanced relaxivity.
Investigative radiology 1994;29 Suppl 2():S69-70.
1994: S Eaton; Michael Tweedle; Ramachandran S Ranganathan
A study of the anticoagulation mechanisms of x-ray contrast media.
Investigative radiology 1994;29 Suppl 2():S201-2.
1994: X Wan; PW Wedeking; Michael Tweedle
Sources of heterogeneous contrast enhancement in the gastrointestinal tract.
Magnetic resonance imaging 1994;12(7):1009-12.
1993: Michael Tweedle
No more Edsel mechanics needed in nuclear medicine.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(10):1826.
1993: PW Wedeking; K Kumar; Michael Tweedle
Dose-dependent biodistribution of [153Gd]Gd(acetate)n in mice.
Nuclear medicine and biology 1993;20(5):679-91.
1993: S M Eaton; PW Wedeking; Michael Tweedle; William Eckelman
A multi-organ, axially distributed model of capillary permeability for a magnetic resonance imaging contrast agent.
Journal of pharmaceutical sciences 1993;82(5):531-6.
1992: Michael Tweedle
Physicochemical properties of gadoteridol and other magnetic resonance contrast agents.
Investigative radiology 1992;27 Suppl 1():S2-6.
1992: PW Wedeking; C H Sotak; J Telser; K Kumar; C A Chang; Michael Tweedle
Quantitative dependence of MR signal intensity on tissue concentration of Gd(HP-DO3A) in the nephrectomized rat.
Magnetic resonance imaging 1992;10(1):97-108.
1992: PW Wedeking; K Kumar; Michael Tweedle
Dissociation of gadolinium chelates in mice: relationship to chemical characteristics.
Magnetic resonance imaging 1992;10(4):641-8.
1991: Michael Tweedle; PW Wedeking; J Telser; C H Sotak; C A Chang; K Kumar; X Wan; S M Eaton
Dependence of MR signal intensity on Gd tissue concentration over a broad dose range.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;22(2):191-4; discussion 195-6.
1991: Ramachandran S Ranganathan; T Arunachalam; G Diamantidis; L Duncan; J Emswiler; E Marinelli; R Neubeck; R Pillai; PW Wedeking; Michael Tweedle
New x-ray contrast agents. The chemical, biological, and physical properties of 5-heterocycle substituted 2,4,6-triiodo-1,3-benzenedicarboxamide derivatives.
Investigative radiology 1991;26 Suppl 1():S156-8; discussion S165-6.
1991: R Shukla; X Zhang; Michael Tweedle
Probes of relaxivity. In vitro determination of correlation times independent of nuclear magnetic resonance dispersion.
Investigative radiology 1991;26 Suppl 1():S224-5; discussion S232-5.
1991: Michael Tweedle
Nonionic or neutral?
Radiology 1991;178(3):891.
1991: Michael Tweedle; James Hagan; K Kumar; S Mantha; C A Chang
Reaction of gadolinium chelates with endogenously available ions.
Magnetic resonance imaging 1991;9(3):409-15.
1990: S Eaton; H M Tsay; F Yost; Michael Tweedle
Assays for plasma complement activation by x-ray contrast media.
Investigative radiology 1990;25(7):789-92.
1990: PW Wedeking; S Eaton; D G Covell; S Nair; Michael Tweedle; William Eckelman
Pharmacokinetic analysis of blood distribution of intravenously administered 153Gd-labeled Gd(DTPA)2- and 99mTc(DTPA) in rats.
Magnetic resonance imaging 1990;8(5):567-75.
1988: Michael Tweedle; S M Eaton; William Eckelman; G T Gaughan; J J Hagan; PW Wedeking; F J Yost
Comparative chemical structure and pharmacokinetics of MRI contrast agents.
Investigative radiology 1988;23 Suppl 1():S236-9.
1988: S M Eaton; J J Hagan; H M Tsay; Michael Tweedle; E L Nickoloff; M D Loberg; F J Yost
A predictive test for adverse reactions to contrast media. Preliminary results.
Investigative radiology 1988;23 Suppl 1():S206-8.
1988: Michael Tweedle; G T Gaughan; J Hagan; PW Wedeking; P Sibley; L J Wilson; D W Lee
Considerations involving paramagnetic coordination compounds as useful NMR contrast agents.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(1):31-6.
1988: PW Wedeking; Michael Tweedle
Comparison of the biodistribution of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n in mice.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1988;15(4):395-402.
1987: S Eaton; H M Tsay; F Yost; Michael Tweedle
Effect of iodinated contrast media on a radioimmunoassay of C3a.
Clinical chemistry 1987;33(8):1470.
1985: Val M. Runge; A C Price; C J Wehr; J B Atkinson; Michael Tweedle
Contrast enhanced MRI. Evaluation of a canine model of osmotic blood-brain barrier disruption.
Investigative radiology 1985;20(8):830-44.
1978: Michael Tweedle; L J Wilson
Electronic state of heme in cytochrome oxidase III. The magnetic susceptibility of beef heart cytochrome oxidase and some of its derivatives from 7-200 K. Direct evidence for an antiferromagnetically coupled Fe (III)/Cu (II) pair.
The Journal of biological chemistry 1978;253(22):8065-71.
1978: Michael Tweedle; Lon J Wilson
Faraday magnetic balance capable of high resolution measurements on metalloprotein solutions from 6.5 to 300 K.
The Review of scientific instruments 1978;49(7):1001.
1977: E V Dose; Michael Tweedle; L J Wilson; N Sutin
A direct measurement of dynamic spin-interconversion rates in the spin-equilibrium protein ferric myoglobin hydroxide.
Journal of the American Chemical Society 1977;99(11):3886-8.