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Derek Middleton

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Colum McErlean; Asensio A Gonzalez; Rodat Cunningham; Ashley Meenagh; Tanya Shovlin; Derek Middleton
Differential RNA expression of KIR alleles.
Theresa A Buckham; Amy Jayne McKnight; David Benevente; Aisling E Courtney; Christopher C Patterson; Matt Simmonds; Steven Gough; Derek Middleton; Richard Borrows; Alexander P Maxwell
Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans.
J McCappin; D Harvey; B P Wordsworth; Derek Middleton
No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis.

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All Publications

2010: Colum McErlean; Asensio A Gonzalez; Rodat Cunningham; Ashley Meenagh; Tanya Shovlin; Derek Middleton
Differential RNA expression of KIR alleles.
Immunogenetics 2010;62(7):431-40.
2010: Theresa A Buckham; Amy Jayne McKnight; David Benevente; Aisling E Courtney; Christopher C Patterson; Matt Simmonds; Steven Gough; Derek Middleton; Richard Borrows; Alexander P Maxwell
Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans.
American journal of nephrology 2010;32(2):103-8.
2010: J McCappin; D Harvey; B P Wordsworth; Derek Middleton
No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis.
Tissue antigens 2010;75(1):68-73.
2009: Asensio Gonzalez; Colum McErlean; Ashley Meenagh; Tanya Shovlin; Derek Middleton
Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting.
Human immunology 2009;70(10):858-63.
2009: Diane Currie; Amy Jayne McKnight; Chris C Patterson; Rosalind J L Martin; Derek Middleton; Aisling E Courtney; A Peter Maxwell
Association of microsatellite markers on chromosomes 6q27 region and 10p15 region with end-stage renal disease in a UK renal transplant population.
Journal of human genetics 2009;54(8):497-8.
2008: Ashley Meenagh; A Gonzalez; Carole Sleator; S McQuaid; Derek Middleton
Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1.
Tissue antigens 2008;72(4):383-91.
2008: A Gonzalez; Ashley Meenagh; Carole Sleator; Derek Middleton
Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.
Tissue antigens 2008;72(1):11-20.
2008: D Ordóñez; A Meenagh; Natalia Gómez-Lozano; J Castaño; Derek Middleton; Carlos Vilches
Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes.
Genes and immunity 2008;9(5):431-7.
2008: Derek Middleton; Ashley Meenagh; Juan Moscoso; A Arnaiz-Villena
Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents.
Tissue antigens 2008;71(2):105-13.
2008: Aisling E Courtney; Peter T McNamee; Shirley Heggarty; Derek Middleton; A Peter Maxwell
Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(2):608-11.
2007: Derek Middleton; Ashley Meenagh; Carole Sleator; Pierre-Antoine Gourraud; T Ayna; H Tozkir; A A Köse; G Azizleri; A Sarper Diler
No association of KIR genes with Behcet's disease.
Tissue antigens 2007;70(5):435-8.
2007: H Abdeen; C McErlean; Maria Moraes; M Torres; S Campiotto; S Galvão; C Gouvea; Derek Middleton
Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population.
Tissue antigens 2007;69(6):607-10.
2007: Derek Middleton; Ashley Meenagh; G D Wright
No association in frequency of KIR receptors in patients with rheumatoid arthritis from Northern Ireland.
Tissue antigens 2007;69(6):577-82.
2007: Derek Middleton; F T Christiansen
14th International HLA and Immunogenetics Workshop: report on KIR receptors and their applications.
Tissue antigens 2007;69 Suppl 1():85-7.
2007: H Abdeen; C McErlean; Maria Moraes; M Romero; S B Marques; A C Goncales; E G Guariento; Derek Middleton
Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population.
Tissue antigens 2007;69(3):273-6.
2007: Derek Middleton; Jose R Vilchez; Teresa Cabrera; Ashley Meenagh; Fionnuala Williams; Iris A Halfpenny; Isabel Maleno; Francisco Ruiz-Cabello; Miguel A Lopez-Nevot; Federico Garrido
Analysis of KIR gene frequencies in HLA class I characterised bladder, colorectal and laryngeal tumours.
Tissue antigens 2007;69(3):220-6.
2007: Stephen A Badger; Chee V Soong; Mark E O'Donnell; Derek Middleton
The role of human leukocyte antigen genes in the formation of abdominal aortic aneurysms.
Journal of vascular surgery 2007;45(3):475-80.
2007: Derek Middleton; Asensio Gonzalez; Paula M Gilmore
Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations.
Human immunology 2007;68(2):128-34.
2007: Derek Middleton; Ashley Meenagh; Pierre-Antoine Gourraud
KIR haplotype content at the allele level in 77 Northern Irish families.
Immunogenetics 2007;59(2):145-58.
2006: Derek Middleton; Iris A Halfpenny; Ashley Meenagh; Fionnuala Williams; Jyrki Sivula; Eva Tuomilehto-Wolf
Investigation of KIR gene frequencies in type 1 diabetes mellitus.
Human immunology 2006;67(12):986-90.
2006: A Méndez; H Granda; Ashley Meenagh; S Contreras; R Zavaleta; M F Mendoza; L Izquierdo; Marìa Elena Sarmiento; Armando Acosta; Derek Middleton
Study of KIR genes in tuberculosis patients.
Tissue antigens 2006;68(5):386-9.
2006: Derek Middleton; Ashley Meenagh; S G E Marsh; J Martin
A HLA-Cw*03 allele, Cw*0322Q with limited or no expression.
Tissue antigens 2006;67(4):343-5.
2006: Bernadette Magee; Jeanie Martin; Derek Middleton
The repercussions of implementing flow cytometry as a single HLA antibody screening technique in prospective renal transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation 2006;19(2):105-9.
2005: Derek Middleton; Fionnuala Williams; Iris A Halfpenny
KIR genes.
Transplant immunology 2005;14(3-4):135-42.
2005: Fionnuala Williams; Ashley Meenagh; Carole Sleator; Daniel Cook; Marcelo Fernandez-Vina; Anne M Bowcock; Derek Middleton
Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.
Human immunology 2005;66(7):836-41.
2005: Natalia Gómez-Lozano; Ernesto Estefanía; Fionnuala Williams; Iris A Halfpenny; Derek Middleton; Rosario Solís; Carlos Vilches
The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated.
European journal of immunology 2005;35(1):16-24.
2004: Ashley Meenagh; Fionnuala Williams; Carole Sleator; Iris A Halfpenny; Derek Middleton
Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2.
Tissue antigens 2004;64(3):226-34.
2004: Lynn D Maxwell; Owen A Ross; Martin D Curran; I Maeve or Maeve Rea; Derek Middleton
Investigation of KIR diversity in immunosenescence and longevity within the Irish population.
Experimental gerontology 2004;39(8):1223-32.
2004: L Keaney; Fionnuala Williams; Ashley Meenagh; Carole Sleator; Derek Middleton
Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3.
Tissue antigens 2004;64(2):188-94.
2004: Lynn D Maxwell; Fionnuala Williams; Paula M Gilmore; Ashley Meenagh; Derek Middleton
Investigation of killer cell immunoglobulin-like receptor gene diversity: II. KIR2DS4.
Human immunology 2004;65(6):613-21.
2004: Iris A Halfpenny; Derek Middleton; Yvonne A Barnett; Fionnuala Williams
Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1.
Human immunology 2004;65(6):602-12.
2004: Derek Middleton; B R Hawkins; Fionnuala Williams; Ashley Meenagh; Juan Moscoso; Jorge Zamora; A Arnaiz-Villena
HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing.
Tissue antigens 2004;63(6):555-61.
2004: Owen A Ross; Claire O'Neill; I Maeve or Maeve Rea; Timothy Lynch; David Gosal; Andrew Wallace; Martin D Curran; Derek Middleton; J Mark Gibson
Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.
Human immunology 2004;65(4):340-6.
2004: Derek Middleton
Are threesomes worth considering?
Transplantation 2004;77(6):801-2.
2004: Derek Middleton; James F Douglas; Gerhard Opelz; Bernd Doehler; Mary G McGeown
One thousand renal transplants in Belfast (1968-1998).
Clinical transplants 2004;():151-64.
2004: Fionnuala Williams; Ashley Meenagh; Rich Single; Mark McNally; Philip Kelly; Mark P Nelson; diogo meyer; Alex Lancaster; Glenys Thomson; Derek Middleton
High resolution HLA-DRB1 identification of a Caucasian population.
Human immunology 2004;65(1):66-77.
2004: Fionnuala Williams; Ashley Meenagh; Carole Sleator; Derek Middleton
Investigation of killer cell immunoglobulinlike receptor gene diversity: I. KIR2DL4.
Human immunology 2004;65(1):31-8.
2003: Fionnuala Williams; Lynn D Maxwell; Iris A Halfpenny; Ashley Meenagh; Carole Sleator; Martin D Curran; Derek Middleton
Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals.
Human immunology 2003;64(7):729-32.
2003: Derek Middleton; L Menchaca; H Rood; R Komerofsky
New allele frequency database: http://www.allelefrequencies.net.
Tissue antigens 2003;61(5):403-7.
2003: Owen A Ross; Martin D Curran; Karen A Crum; I Maeve or Maeve Rea; Yvonne A Barnett; Derek Middleton
Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population.
Experimental gerontology 2003;38(5):561-5.
2003: Mark A Cook; Paul J Norman; Martin D Curran; Lynn D Maxwell; David C Briggs; Derek Middleton; Robert W Vaughan
A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines.
Human immunology 2003;64(5):567-71.
2003: Owen A Ross; Martin D Curran; I Maeve or Maeve Rea; Paul Hyland; Orla Duggan; Christopher R Barnett; Kathryn Annett; Chris Patterson; Yvonne A Barnett; Derek Middleton
HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.
Mechanisms of ageing and development 2003;124(4):563-7.
2003: I Maeve or Maeve Rea; Owen A Ross; Marilyn Armstrong; Susan E McNerlan; Denis H Alexander; Martin D Curran; Derek Middleton
Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants.
Mechanisms of ageing and development 2003;124(4):555-61.
2003: Owen A Ross; Rose McCormack; Lynn D Maxwell; R Alistair Duguid; Derek J Quinn; Yvonne A Barnett; I Maeve or Maeve Rea; Omar M A El-Agnaf; J Mark Gibson; Andrew Wallace; Derek Middleton; Martin D Curran
mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish.
Experimental gerontology 2003;38(4):397-405.
2003: Owen A Ross; Martin D Curran; Ashley Meenagh; Fionnuala Williams; Yvonne A Barnett; Derek Middleton; I Maeve or Maeve Rea
Study of age-association with cytokine gene polymorphisms in an aged Irish population.
Mechanisms of ageing and development 2003;124(2):199-206.
2003: Derek Middleton; Fionnuala Williams
PCR-sequence-specific oligonucleotide probe typing for HLA-A, -B, and -DR.
Methods in molecular biology (Clifton, N.J.) 2003;210():67-112.
2002: Rose McCormack; A Peter Maxwell; Dennis J Carson; Chris C Patterson; Derek Middleton; David A Savage
The IL12B 3' untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes.
Genes and immunity 2002;3(7):433-5.
2002: Ashley Meenagh; Fionnuala Williams; Owen A Ross; Chris Patterson; Clara Gorodezky; Mike Hammond; William A Leheny; Derek Middleton
Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.
Human immunology 2002;63(11):1055-61.
2002: Owen A Ross; Nuri H Awayn; Deborah McWhinney; Lynn D Maxwell; Omar M A El-Agnaf; Yvonne A Barnett; I Maeve or Maeve Rea; Derek Middleton; Andrew Wallace; J Mark Gibson; Martin D Curran
A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish.
Neuroreport 2002;13(13):1621-5.
2002: Lynn D Maxwell; Andrew Wallace; Derek Middleton; Martin D Curran
A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey.
Tissue antigens 2002;60(3):254-8.
2002: Derek Middleton; Martin Curran; Lynne Maxwell
Natural killer cells and their receptors.
Transplant immunology 2002;10(2-3):147-64.
2002: Fionnuala Williams; Ashley Meenagh; Chris Patterson; Derek Middleton
Molecular diversity of the HLA-C gene identified in a caucasian population.
Human immunology 2002;63(7):602-13.
2002: Brian P McIlhatton; Caitriona Keating; Martin D Curran; Mary-Frances McMullin; Jack G Barr; J Alejandro Madrigal; Derek Middleton
Identification of medically important pathogenic fungi by reference strand-mediated conformational analysis (RSCA).
Journal of medical microbiology 2002;51(6):468-78.
2002: Owen A Ross; Paul Hyland; Martin D Curran; Brian P McIlhatton; Anders Wikby; Boo Johansson; Andrea Tompa; Graham Pawelec; Christopher R Barnett; Derek Middleton; Yvonne A Barnett
Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?
Experimental gerontology 2002;37(2-3):329-40.
2001: Owen A Ross; Rose McCormack; Martin D Curran; R A Duguid; Yvonne A Barnett; I Maeve or Maeve Rea; Derek Middleton
Mitochondrial DNA polymorphism: its role in longevity of the Irish population.
Experimental gerontology 2001;36(7):1161-78.
2001: Fionnuala Williams; Ashley Meenagh; C Darke; Armando Acosta; AS Daar; Clara Gorodezky; Mike Hammond; E Nascimento; Derek Middleton
Analysis of the distribution of HLA-B alleles in populations from five continents.
Human immunology 2001;62(6):645-50.
2001: Derek Middleton; Martin D Curran; Jacqy D H Anholts; E R Reilly; G M Th Schreuder
Characterisation of a new HLA-B allele, HLA-B*0724.
Tissue antigens 2001;57(5):471-3.
2001: Fionnuala Williams; Martin D Curran; M Padadoa Perez; Armando Acosta; Derek Middleton
Characterisation of a new HLA-B allele, HLA-B*0720, identified in the Cuban population.
Tissue antigens 2001;57(1):80-2.
2000: Derek Middleton; Fionnuala Williams; M A Hamill; Ashley Meenagh
Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy.
Human immunology 2000;61(12):1285-97.
2000: Fionnuala Williams; Martin D Curran; William A Leheny; AS Daar; Derek Middleton
Characterization of HLA-B*3921 and confirmation of HLA-B*4415, two variant HLA-B alleles identified in the Omani population.
Tissue antigens 2000;56(4):376-9.
2000: K A Crum; S E Logue; Martin D Curran; Derek Middleton
Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires.
Tissue antigens 2000;56(4):313-26.
2000: Derek Middleton; Fionnuala Williams; Ashley Meenagh; AS Daar; Clara Gorodezky; Mike Hammond; E Nascimento; I Briceno; M P Perez
Analysis of the distribution of HLA-A alleles in populations from five continents.
Human immunology 2000;61(10):1048-52.
2000: Z R Zolnourian; Martin D Curran; Bertus K Rima; Peter V Coyle; H J O'Neill; Derek Middleton
Parvovirus B19 in kidney transplant patients.
Transplantation 2000;69(10):2198-202.
2000: Paul Hyland; A L Keegan; M D Curran; Derek Middleton; PG McKenna; Yvonne A Barnett
Effect of a dCTP:dTTP pool imbalance on DNA replication fidelity in Friend murine erythroleukemia cells.
Environmental and molecular mutagenesis 2000;36(2):87-96.
1999: D Neill; Martin D Curran; Derek Middleton; H Mawhinney; JA Edwardson; Ian G McKeith; Clive G Ballard; C Morris; Paul Ince; Evelyn Jaros; Robert H Perry
Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03.
Neuroscience letters 1999;275(2):137-40.
1999: Fionnuala Williams; Martin D Curran; Derek Middleton
Characterisation of a novel HLA-A pseudogene, HLA-BEL, with significant sequence identity with a gorilla MHC class I gene.
Tissue antigens 1999;54(4):360-9.
1999: Fionnuala Williams; Ashley Meenagh; A P Maxwell; Derek Middleton
Allele resolution of HLA-A using oligonucleotide probes in a two-stage typing strategy.
Tissue antigens 1999;54(1):59-68.
1999: Derek Middleton; H Mawhinney; Martin D Curran; JA Edwardson; Robert H Perry; Ian G McKeith; C Morris; Paul Geoffrey Ince; D Neill
Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease.
Neuroscience letters 1999;262(2):140-2.
1999: Martin D Curran; Fionnuala Williams; A M Little; Bertus K Rima; J A Madrigal; Derek Middleton
Aberrant splicing of intron 1 creates a novel null HLA-B*1501 allele.
Tissue antigens 1999;53(3):244-52.
1998: Omar M A El-Agnaf; Martin D Curran; Andrew Wallace; Derek Middleton; C Murgatroyd; A Curtis; Robert H Perry; Evelyn Jaros
Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.
Neuroreport 1998;9(17):3925-7.
1998: Omar M A El-Agnaf; R Jakes; Martin D Curran; Derek Middleton; Raffaele Ingenito; E Bianchi; Antonello Pessi; D Neill; Andrew Wallace
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.
FEBS letters 1998;440(1-2):71-5.
1998: S Murphy; Martin D Curran; Neil I McDougall; M E Callender; C J O'Brien; Derek Middleton
High incidence of the Cys 282 Tyr mutation in the HFE gene in the Irish population--implications for haemochromatosis.
Tissue antigens 1998;52(5):484-8.
1998: Fionnuala Williams; Martin D Curran; Derek Middleton
Detection of HLA-A*24 null alleles by DNA typing methods.
Tissue antigens 1998;52(3):208-12.
1997: Martin Curran; Derek Middleton; JA Edwardson; Robert H Perry; Ian G McKeith; C Morris; D Neill
HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease.
Neuroreport 1997;8(6):1467-9.
1997: Paul Hyland; M W McKinney; A L Keegan; PG McKenna; M D Curran; Derek Middleton; Yvonne A Barnett
Sequence analysis of spontaneously-arising mutations at the aprt locus in wild-type and thymidine kinase-deficient Friend cells: evidence for strand slippage-misalignment mechanism in formation of deletions.
Biochemical Society transactions 1997;25(1):127S.