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Robert Clarke

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Yuriy Gusev; Krithika Bhuvaneshwar; Robert Clarke; Robinder Gauba; Rebecca B Riggins; Laura Sheahan; Subha Madhavan
In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.
Li Chen; Rebecca B Riggins; Yue Wang; Jianhua Xuan; Robert Clarke
Identifying protein interaction subnetworks by a bagging Markov random field-based method.
Katherine L Cook; Robert Clarke
Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy.

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2013: Yuriy Gusev; Krithika Bhuvaneshwar; Robert Clarke; Robinder Gauba; Rebecca B Riggins; Laura Sheahan; Subha Madhavan
In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.
Cancer informatics 2013;12():31-51.
2013: Li Chen; Rebecca B Riggins; Yue Wang; Jianhua Xuan; Robert Clarke
Identifying protein interaction subnetworks by a bagging Markov random field-based method.
Nucleic acids research 2013;41(2):e42.
2012: Katherine L Cook; Robert Clarke
Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy.
Autophagy 2012;8(12):1827-9.
2012: Jinghua Gu; Rebecca B Riggins; Yue Wang; Jianhua Xuan; Li Chen; Robert Clarke
Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic.
Bioinformatics (Oxford, England) 2012;28(15):1990-7.
2012: Ayesha N Shajahan; Sivanesan Dakshanamurthy; Zachary C Dobbin; F Edward Hickman; Robert Clarke
Tyrosine-phosphorylated caveolin-1 (Tyr-14) increases sensitivity to paclitaxel by inhibiting BCL2 and BCLxL proteins via c-Jun N-terminal kinase (JNK).
The Journal of biological chemistry 2012;287(21):17682-92.
2012: Denzel R Woode; Alan L Zwart; Harini S Aiyer; Liya Li; Navindra P Seeram; Nicole Sie; Robert Clarke
Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines.
International journal of breast cancer 2012;2012():147828.
2012: Xiguo Yuan; Junying Zhang; Zhen Zhang; Guoqiang Yu; Robert Clarke; Eric Paul Hoffman; Xuchu Hou; Ie-Ming Shih; Roger R Wang; Yue Wang
Genome-wide identification of significant aberrations in cancer genome.
BMC genomics 2012;13():342.
2011: Subha Madhavan; Rebecca B Riggins; Kevin Rosso; Andrew Shinohara; Lei Song; David M Tanenbaum; Yue Wang; Krithika Bhuvaneshwar; Stephen W Byers; Lavinia A Carabet; Robert Clarke; Sivanesan Dakshanamurthy; Robinder Gauba; Yuriy Gusev; Michael Harris; Louis M Weiner
G-DOC: a systems medicine platform for personalized oncology.
Neoplasia (New York, N.Y.) 2011;13(9):771-83.
2011: Katherine L Cook; Ayesha N Shajahan; Robert Clarke
Autophagy and endocrine resistance in breast cancer.
Expert review of anticancer therapy 2011;11(8):1283-94.
2011: Zhihua Ren; Dusan Stefoski; Duan Tao; Yan Wang; Robert Clarke; Rajendra Goswami; David Liebenson; Thomas Liggett; Roumen Balabanov
Overexpression of the dominant-negative form of interferon regulatory factor 1 in oligodendrocytes protects against experimental autoimmune encephalomyelitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(23):8329-41.
2011: J L Schwartz; Ayesha N Shajahan; Robert Clarke
The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer.
International journal of breast cancer 2011;2011():912102.
2011: Li Chen; Robert Clarke; Rebecca B Riggins; Jianhua Xuan; Yue Wang
Identifying cancer biomarkers by network-constrained support vector machines.
BMC systems biology 2011;5():161.
2011: Robert Clarke
Cannibalism, cell survival, and endocrine resistance in breast cancer.
Breast cancer research : BCR 2011;13(4):311.
2010: Rebecca Riggins; Mary M Mazzotta; Omar Z Maniya; Robert Clarke
Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.
Endocrine-related cancer 2010;17(3):R213-31.
2010: Li Chen; Jianhua Xuan; Rebecca Riggins; Yue Wang; Eric Hoffman; Robert Clarke
Multilevel support vector regression analysis to identify condition-specific regulatory networks.
Bioinformatics (Oxford, England) 2010;26(11):1416-22.
2010: Ruchi Nehra; Rebecca Riggins; Ayesha N Shajahan; Alan Zwart; Anatasha C Crawford; Robert Clarke
BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(6):2040-55.
2010: Yanxia Ning; Rebecca Riggins; Jennifer E Mulla; Haniee Chung; Alan Zwart; Robert Clarke
IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.
Molecular cancer therapeutics 2010;9(5):1274-85.
2010: Luciane Cavalli; Rebecca Riggins; Antai Wang; Robert Clarke; Bassem R Haddad
Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer.
Breast cancer research and treatment 2010;121(1):227-31.
2010: Yuji Zhang; Jianhua Xuan; Benildo G de los Reyes; Robert Clarke; Habtom W Ressom
Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration.
PloS one 2010;5(4):e10268.
2010: Chen Wang; Jianhua Xuan; Huai Li; Yue Wang; Ming Zhan; Eric Hoffman; Robert Clarke
Knowledge-guided gene ranking by coordinative component analysis.
BMC bioinformatics 2010;11():162.
2010: Anatasha C Crawford; Rebecca Riggins; Ayesha N Shajahan; Alan Zwart; Robert Clarke
Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.
PloS one 2010;5(1):e8604.
2010: Jianhua Xuan; Yue Wang; Eric Hoffman; Robert Clarke
Cross phenotype normalization of microarray data.
Frontiers in bioscience (Elite edition) 2010;2():171-86.
2009: Ayesha N Shajahan; Rebecca Riggins; Robert Clarke
The role of X-box binding protein-1 in tumorigenicity.
Drug news & perspectives 2009;22(5):241-6.
2009: Robert Clarke; Ayesha N Shajahan; Rebecca Riggins; Younsook Cho; Anatasha Crawford; Jianhua Xuan; Yue Wang; Alan Zwart; Ruchi Nehra; Minetta C Liu
Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2009;114(1-2):8-20.
2009: Bai Zhang; Huai Li; Rebecca Riggins; Ming Zhan; Jianhua Xuan; Zhen Zhang; Eric Hoffman; Robert Clarke; Yue Wang
Differential dependency network analysis to identify condition-specific topological changes in biological networks.
Bioinformatics (Oxford, England) 2009;25(4):526-32.
2009: Li Chen; Jianhua Xuan; Yue Wang; Eric Hoffman; Rebecca B Riggins; Robert Clarke
Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis.
International journal of computational biology and drug design 2009;2(1):1-20.
2009: Li Chen; Jianhua Xuan; Chen Wang; Yue Wang; Ie-Ming Shih; Tian-Li Wang; Zhen Zhang; Robert Clarke; Eric Hoffman
Biomarker identification by knowledge-driven multilevel ICA and motif analysis.
International journal of data mining and bioinformatics 2009;3(4):365-81.
2009: Robert Clarke
The role of preclinical animal models in breast cancer drug development.
Breast cancer research : BCR 2009;11 Suppl 3():S22.
2009: Yuji Zhang; Jianhua Xuan; Benildo G de los Reyes; Robert Clarke; Habtom W Ressom
Reverse engineering module networks by PSO-RNN hybrid modeling.
BMC genomics 2009;10 Suppl 1():S15.
2008: Susan E Olivo-Marston; Yuelin Zhu; Richard Y Lee; Anna Cabanes; Galam Khan; Alan Zwart; Yue Wang; Robert Clarke; Leena Hilakivi-Clarke
Gene signaling pathways mediating the opposite effects of prepubertal low-fat and high-fat n-3 polyunsaturated fatty acid diets on mammary cancer risk.
Cancer prevention research (Philadelphia, Pa.) 2008;1(7):532-45.
2008: Rebecca Riggins; Jennifer P-J Lan; Yuelin Zhu; Uwe Klimach; Alan Zwart; Luciane Cavalli; Bassem R Haddad; Li Chen; Ting Gong; Jianhua Xuan; Stephen Ethier; Robert Clarke
ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer.
Cancer research 2008;68(21):8908-17.
2008: Yihan Wang; D J Miller; Robert Clarke
Approaches to working in high-dimensional data spaces: gene expression microarrays.
British journal of cancer 2008;98(6):1023-8.
2008: Yuji Zhang; Jianhua Xuan; Benilo G de Los Reyes; Robert Clarke; Habtom W Ressom
Network motif-based identification of breast cancer susceptibility genes.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2008;2008():5696-9.
2008: Li Chen; Jianhua Xuan; Chen Wang; Ie-Ming Shih; Yue Wang; Zhen Zhang; Eric Hoffman; Robert Clarke
Knowledge-guided multi-scale independent component analysis for biomarker identification.
BMC bioinformatics 2008;9():416.
2008: Yitan Zhu; Huai Li; David J Miller; Zuyi Wang; Jianhua Xuan; Robert Clarke; Eric Hoffman; Yue Wang
caBIG VISDA: modeling, visualization, and discovery for cluster analysis of genomic data.
BMC bioinformatics 2008;9():383.
2008: Yitan Zhu; Zuyi Wang; David J Miller; Robert Clarke; Jianhua Xuan; Eric Hoffman; Yue Wang
A ground truth based comparative study on clustering of gene expression data.
Frontiers in bioscience : a journal and virtual library 2008;13():3839-49.
2008: Yuji Zhang; Jianhua Xuan; Benildo G de los Reyes; Robert Clarke; Habtom W Ressom
Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data.
BMC bioinformatics 2008;9():203.
2008: Chen Wang; Jianhua Xuan; Li Chen; Po Zhao; Yue Wang; Robert Clarke; Eric Hoffman
Motif-directed network component analysis for regulatory network inference.
BMC bioinformatics 2008;9 Suppl 1():S21.
2008: Robert Clarke; Habtom W Ressom; Antai Wang; Jianhua Xuan; Minetta C Liu; Edmund Gehan; Yue Wang
The properties of high-dimensional data spaces: implications for exploring gene and protein expression data.
Nature reviews. Cancer 2008;8(1):37-49.
2008: Habtom W Ressom; Rency S Varghese; Zhen Zhang; Jianhua Xuan; Robert Clarke
Classification algorithms for phenotype prediction in genomics and proteomics.
Frontiers in bioscience : a journal and virtual library 2008;13():691-708.
2007: Bianca Gomez; Rebecca Riggins; Ayesha N Shajahan; Uwe Klimach; Aifen Wang; Anatasha C Crawford; Yuelin Zhu; Alan Zwart; Mingyue Wang; Robert Clarke
Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(14):4013-27.
2007: Catherine Naughton; Kenneth MacLeod; Barbara Kuske; Robert Clarke; David A Cameron; Simon P Langdon
Progressive loss of estrogen receptor alpha cofactor recruitment in endocrine resistance.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2615-26.
2007: Jiajing Wang; Huai Li; Yitan Zhu; Malik Yousef; Michael Nebozhyn; Michael K Showe; Louise C Showe; Jianhua Xuan; Robert Clarke; Yue Wang
VISDA: an open-source caBIG analytical tool for data clustering and beyond.
Bioinformatics (Oxford, England) 2007;23(15):2024-7.
2007: Kerrie B Bouker; Todd C Skaar; David S Harburger; Rebecca Riggins; David R Fernandez; Alan Zwart; Robert Clarke
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.
Cancer genetics and cytogenetics 2007;175(1):61-4.
2007: Ayesha N Shajahan; Aifen Wang; Markus Decker; Richard D Minshall; Minetta C Liu; Robert Clarke
Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.
The Journal of biological chemistry 2007;282(8):5934-43.
2007: Ting Gong; Jianhua Xuan; Chen Wang; Huai Li; Eric Hoffman; Robert Clarke; Yue Wang
Gene module identification from microarray data using nonnegative independent component analysis.
Gene regulation and systems biology 2007;1():349-63.
2007: Jianhua Xuan; Yue Wang; Yibin Dong; Yuanjian Feng; Bin Wang; Javed Khan; Maria Bakay; Zuyi Wang; Lauren M Pachman; Sara Winokur; Yi-Wen Chen; Robert Clarke; Eric Hoffman
Gene selection for multiclass prediction by weighted Fisher criterion.
EURASIP journal on bioinformatics & systems biology 2007;():64628.
2006: Barbara Kuske; Catherine Naughton; Kate Moore; Kenneth G Macleod; William R Miller; Robert Clarke; Simon P Langdon; David A Cameron
Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models.
Endocrine-related cancer 2006;13(4):1121-33.
2006: Li Hua Wang; Xiao Yi Yang; Xiaohu Zhang; Ping An; Han-Jong Kim; Jiaqiang Huang; Robert Clarke; C Kent Osborne; John K Inman; Ettore Appella; William L Farrar
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer.
Cancer cell 2006;10(6):487-99.
2006: Yuelin Zhu; Antai Wang; Minetta C Liu; Alan Zwart; Richard Y Lee; Ann Gallagher; Yue Wang; William R Miller; J Michael Dixon; Robert Clarke
Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures.
International journal of oncology 2006;29(6):1581-9.
2006: Rebecca Riggins; Keena S Thomas; Huy Ta; Jie Wen; Rebecca J Davis; Natasha R Schuh; Stacey S Donelan; Katherine A Owen; Matthew A Gibson; Margaret A Shupnik; Corinne M Silva; Sarah J Parsons; Robert Clarke; Amy H Bouton
Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.
Cancer research 2006;66(14):7007-15.
2006: Bruce J Trock; Leena Hilakivi-Clarke; Robert Clarke
Meta-analysis of soy intake and breast cancer risk.
Journal of the National Cancer Institute 2006;98(7):459-71.
2006: Zuyi Wang; Yue Wang; Jianhua Xuan; Yibin Dong; Marina Bakay; Yuanjian Feng; Robert Clarke; Eric Hoffman
Optimized multilayer perceptrons for molecular classification and diagnosis using genomic data.
Bioinformatics (Oxford, England) 2006;22(6):755-61.
2006: Ting Gong; Yitan Zhu; Jianhua Xuan; Huai Li; Robert Clarke; Eric Hoffman; Yue Wang
Latent variable and nICA modeling of pathway gene module composite.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():5872-5.
2006: Habtom W Ressom; Yuji Zhang; Jianhua Xuan; Yue Wang; Robert Clarke
Inferring network interactions using recurrent neural networks and swarm intelligence.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2006;1():4241-4.
2006: Lee-Jun C Wong; Pu Dai; Jyh-Feng Lu; Mary Ann Lou; Robert Clarke; Viktor Nazarov
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
BMC cancer 2006;6():111.
2006: Yuelin Zhu; Baljit Singh; Stephen Hewitt; Aiyi Liu; Bianca Gomez; Antai Wang; Robert Clarke
Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays.
International journal of oncology 2006;28(1):67-76.
2005: Robert Clarke; Fabio Leonessa; Bruce J Trock
Multidrug resistance/P-glycoprotein and breast cancer: review and meta-analysis.
Seminars in oncology 2005;32(6 Suppl 7):S9-15.
2005: Leena Hilakivi-Clarke; Susan Olivo; Ayesha N Shajahan; Galam Khan; Yuelin Zhu; Alan Zwart; Elizabeth Cho; Robert Clarke
Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats.
The Journal of nutrition 2005;135(12 Suppl):2946S-2952S.
2005: Hiromitsu Kishimoto; Zhuo Wang; Poornima Bhat-Nakshatri; David Chang; Robert Clarke; Harikrishna Nakshatri
The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.
Carcinogenesis 2005;26(10):1706-15.
2005: Kerrie B Bouker; Todd C Skaar; Rebecca Riggins; David S Harburger; David R Fernandez; Alan Zwart; Antai Wang; Robert Clarke
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.
Carcinogenesis 2005;26(9):1527-35.
2005: Rebecca Riggins; Amy H Bouton; Minetta C Liu; Robert Clarke
Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer.
Vitamins and hormones 2005;71():201-37.
2005: Rebecca Riggins; Alan Zwart; Ruchi Nehra; Robert Clarke
The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.
Molecular cancer therapeutics 2005;4(1):33-41.
2004: Luis A Espinoza; Peijun Li; Richard Y Lee; Yue Wang; A Hamid Boulares; Robert Clarke; Mark E Smulson
Evaluation of gene expression profile of keratinocytes in response to JP-8 jet fuel.
Toxicology and applied pharmacology 2004;200(2):93-102.
2004: Kerrie B Bouker; Todd C Skaar; David R Fernandez; Kerry A O'Brien; Rebecca Riggins; Donghua Cao; Robert Clarke
interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).
Cancer research 2004;64(11):4030-9.
2004: Feng Han; Richard Miksicek; Robert Clarke; Susan E Conrad
Expression of an estrogen receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance.
Journal of molecular endocrinology 2004;32(3):935-45.
2004: James M Rae; Susan J Ramus; Mark Waltham; Jane E Armes; Ian G Campbell; Robert Clarke; Robert J Barndt; Michael Johnson; Erik W Thompson
Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.
Clinical & experimental metastasis 2004;21(6):543-52.
2004: Erik W Thompson; Mark Waltham; Susan J Ramus; Anne-Marie Hutchins; Jane E Armes; Ian G Campbell; Elizabeth D Williams; Phillip R Thompson; James M Rae; Michael Johnson; Robert Clarke
LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines.
Clinical & experimental metastasis 2004;21(6):535-41.
2003: Robert Clarke; Minetta C Liu; Kerrie B Bouker; Zhiping Gu; Richard Y Lee; Yuelin Zhu; Todd C Skaar; Bianca Gomez; Kerry O'Brien; Yue Wang; Leena Hilakivi-Clarke
Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.
Oncogene 2003;22(47):7316-39.
2003: M A Christine Pratt; Tanya E Bishop; Dawn White; Gordon Yasvinski; Michel Ménard; Min-Ying Niu; Robert Clarke
Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence.
Molecular and cellular biology 2003;23(19):6887-900.
2003: Michael Johnson; Nicholas Kenney; Adriana Stoica; Leena Hilakivi-Clarke; Baljit Singh; Gloria Chepko; Robert Clarke; Peter F Sholler; Apolonio A Lirio; Colby Foss; Ronald Reiter; Bruce J Trock; Soonmyoung Paik; Mary Beth Martin
Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland.
Nature medicine 2003;9(8):1081-4.
2003: F Leonessa; Robert Clarke
ATP binding cassette transporters and drug resistance in breast cancer.
Endocrine-related cancer 2003;10(1):43-73.
2002: Aiyi Liu; Ying Zhang; Edmund Gehan; Robert Clarke
Block principal component analysis with application to gene microarray data classification.
Statistics in medicine 2002;21(22):3465-74.
2002: Leena Hilakivi-Clarke; Elizabeth Cho; Anna Cabanes; Sonia de Assis; Susan Olivo; William Helferich; Marc Lippman; Robert Clarke
Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3601-10.
2002: Zhiping Gu; Richard Y Lee; Todd C Skaar; Kerrie B Bouker; James N Welch; Jianping Lu; Aiyi Liu; Yuelin Zhu; Natalie Davis; Fabio Leonessa; Nils Brünner; Yue Wang; Robert Clarke
Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).
Cancer research 2002;62(12):3428-37.
2002: Matthew Ellis; Natalie Davis; Andrew Coop; Minetta Liu; Lisa Schumaker; Richard Y Lee; Rujirutana Srikanchana; Chris G Russell; Baljit Singh; William R Miller; Vered Stearns; Marie Pennanen; Theodore Tsangaris; Ann Gallagher; Aiyi Liu; Alan Zwart; Daniel F Hayes; Marc Lippman; Yue Wang; Robert Clarke
Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1155-66.
2002: Yue Wang; Jianping Lu; Richard Lee; Zhiping Gu; Robert Clarke
Iterative normalization of cDNA microarray data.
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society 2002;6(1):29-37.
2002: Leena Hilakivi-Clarke; Anna Cabanes; Susan Olivo; Leslie Kerr; Kerrie B Bouker; Robert Clarke
Do estrogens always increase breast cancer risk?
The Journal of steroid biochemistry and molecular biology 2002;80(2):163-74.
2002: Indira Poola; Robert Clarke; Robert DeWitty; LaSelle D Leffall
Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women.
Cancer 2002;94(3):615-23.
2002: Fabio Leonessa; Ji-Hyun Kim; Alem Ghiorghis; Robert J Kulawiec; Charles Hammer; Abdelhossein Talebian; Robert Clarke
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Journal of medicinal chemistry 2002;45(2):390-8.
2001: Lili Lu; Fabio Leonessa; Michael T Baynham; Robert Clarke; François Gimenez; YT Pham; Françoise Roux; irving william wainer
The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.
Pharmaceutical research 2001;18(9):1327-30.
2001: Robert Clarke
92nd AACR. Novel molecular targets and drugs.
IDrugs : the investigational drugs journal 2001;4(5):504-6.
2001: M R James; Todd C Skaar; Richard Y Lee; A MacPherson; JA Zwiebel; B S Ahluwalia; F Ampy; Robert Clarke
Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo.
Endocrinology 2001;142(4):1497-505.
2001: Robert Clarke; Fabio Leonessa; James N Welch; Todd C Skaar
Cellular and molecular pharmacology of antiestrogen action and resistance.
Pharmacological reviews 2001;53(1):25-71.
2001: Robert Clarke; Leena Hilakivi-Clarke; Bruce J Trock
Breast cancer: dietary and environmental oestrogens.
Biologist (London, England) 2001;48(1):21-6.
2001: Robert Clarke; Todd C Skaar; Kerrie B Bouker; Natalie Davis; Y R Lee; James N Welch; Fabio Leonessa
Molecular and pharmacological aspects of antiestrogen resistance.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):71-84.
2001: Leena Hilakivi-Clarke; Elizabeth Cho; Sonia de Assis; Susan Olivo; Erica L Ealley; Kerrie B Bouker; James N Welch; Galam Khan; Robert Clarke; Anna Cabanes
Maternal and prepubertal diet, mammary development and breast cancer risk.
The Journal of nutrition 2001;131(1):154S-157S.
2001: Lili Lu; Fabio Leonessa; Robert Clarke; irving william wainer
Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase.
Molecular pharmacology 2001;59(1):62-8.
2000: Y Zhang; Fabio Leonessa; Robert Clarke; irving william wainer
Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities.
Journal of chromatography. B, Biomedical sciences and applications 2000;739(1):33-7.
2000: L Halakivi-Clarke; Elizabeth Cho; I Onojafe; Dezhong Joshua Liao; Robert Clarke
Maternal exposure to tamoxifen during pregnancy increases carcinogen-induced mammary tumorigenesis among female rat offspring.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):305-8.
1999: C A Plouzek; Henry P Ciolino; Robert Clarke; Grace Chao Yeh
Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract.
European journal of cancer (Oxford, England : 1990) 1999;35(10):1541-5.
1999: Leena Hilakivi-Clarke; Elizabeth Cho; I Onojafe; Margarita Raygada; Robert Clarke
Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring.
Oncology reports 1999;6(5):1089-95.
1999: Leena Hilakivi-Clarke; I Onojafe; Margarita Raygada; Elizabeth Cho; Todd C Skaar; I Russo; Robert Clarke
Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis.
British journal of cancer 1999;80(11):1682-8.
1999: MC Lavigne; PW Ramwell; Robert Clarke
Inhibition of estrogen receptor function promotes porcine coronary artery smooth muscle cell proliferation.
Steroids 1999;64(7):472-80.
1999: Erik W Thompson; V Sung; M Lavigne; K Baumann; Norio Azumi; AD Aaron; Robert Clarke
LCC15-MB: a vimentin-positive human breast cancer cell line from a femoral bone metastasis.
Clinical & experimental metastasis 1999;17(3):193-204.
1999: Leena Hilakivi-Clarke; Robert Clarke; Marc Lippman
The influence of maternal diet on breast cancer risk among female offspring.
Nutrition (Burbank, Los Angeles County, Calif.) 1999;15(5):392-401.
1999: MC Lavigne; PW Ramwell; Robert Clarke
Growth and phenotypic characterization of porcine coronary artery smooth muscle cells.
In vitro cellular & developmental biology. Animal 1999;35(3):136-43.
1999: Rayudu Gopalakrishna; Usha Gundimeda; Joseph A Fontana; Robert Clarke
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status.
Cancer letters 1999;136(2):143-51.
1999: Carlos L Arteaga; KM Koli; Teresa C Dugger; Robert Clarke
Reversal of tamoxifen resistance of human breast carcinomas in vivo by neutralizing antibodies to transforming growth factor-beta.
Journal of the National Cancer Institute 1999;91(1):46-53.
1998: Todd C Skaar; SC Prasad; S Sharareh; Marc Lippman; Nils Brünner; Robert Clarke
Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1998;67(5-6):391-402.
1998: B Brankin; Todd C Skaar; M Brotzman; Bruce J Trock; Robert Clarke
Autoantibodies to the nuclear phosphoprotein nucleophosmin in breast cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1998;7(12):1109-15.
1998: Leena Hilakivi-Clarke; Robert Clarke
Timing of dietary fat exposure and mammary tumorigenesis: role of estrogen receptor and protein kinase C activity.
Molecular and cellular biochemistry 1998;188(1-2):5-12.
1998: V Sung; Christine Gilles; A Murray; Robert Clarke; AD Aaron; Norio Azumi; Erik W Thompson
The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype.
Experimental cell research 1998;241(2):273-84.
1998: Leena Hilakivi-Clarke; Elizabeth Cho; Robert Clarke
Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring.
Oncology reports 1998;5(3):609-16.
1997: Robert Clarke
Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models.
Breast cancer research and treatment 1997;46(2-3):255-78.
1997: Robert Clarke
Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research.
Breast cancer research and treatment 1997;46(2-3):117-33.
1997: L Jørgensen; Nils Brünner; Mogens Spang-Thomsen; M R James; Robert Clarke; Per Dombernowsky; B Svenstrup
Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations MCF-7/LCC1 and MCF-7/LCC2.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):275-81.
1997: Leena Hilakivi-Clarke; Robert Clarke; I Onojafe; Margarita Raygada; Elizabeth Cho; Marc Lippman
A maternal diet high in n - 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9372-7.
1997: Nils Brünner; B Boysen; S Jirus; T C Skaar; C Holst-Hansen; J Lippman; Thomas L Frandsen; Mogens Spang-Thomsen; S A Fuqua; Robert Clarke
MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen.
Cancer research 1997;57(16):3486-93.
1997: Bruce J Trock; Fabio Leonessa; Robert Clarke
Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.
Journal of the National Cancer Institute 1997;89(13):917-31.
1996: Leena Hilakivi-Clarke; I Onojafe; Margarita Raygada; Elizabeth Cho; Robert Clarke; Marc Lippman
Breast cancer risk in rats fed a diet high in n-6 polyunsaturated fatty acids during pregnancy.
Journal of the National Cancer Institute 1996;88(24):1821-7.
1996: Robert Clarke; N Brünner
Acquired estrogen independence and antiestrogen resistance in breast cancer: estrogen receptor driven phenotypes?
Trends in endocrinology and metabolism: TEM 1996;7(8):291-301.
1996: M Bei; M C Lavigne; ML Foegh; PW Ramwell; Robert Clarke
Specific binding of estradiol to rat coronary artery smooth muscle cells.
The Journal of steroid biochemistry and molecular biology 1996;58(1):83-8.
1996: Robert Clarke; Todd C Skaar; F Leonessa; B Brankin; M James; Nils Brünner; Marc Lippman
Acquisition of an antiestrogen-resistant phenotype in breast cancer: role of cellular and molecular mechanisms.
Cancer treatment and research 1996;87():263-83.
1996: Robert Clarke; Leena Hilakivi-Clarke; Elizabeth Cho; M R James; F Leonessa
Estrogens, phytoestrogens, and breast cancer.
Advances in experimental medicine and biology 1996;401():63-85.
1996: Robert Clarke
Human breast cancer cell line xenografts as models of breast cancer. The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines.
Breast cancer research and treatment 1996;39(1):69-86.
1996: Robert Clarke
Animal models of breast cancer: their diversity and role in biomedical research.
Breast cancer research and treatment 1996;39(1):1-6.
1996: F Leonessa; D Green; T Licht; A Wright; K Wingate-Legette; J Lippman; Michael M Gottesman; Robert Clarke
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.
British journal of cancer 1996;73(2):154-61.
1995: Leena Hilakivi-Clarke; Elizabeth Cho; Margarita Raygada; I Onojafe; Robert Clarke; Marc Lippman
Early life affects the risk of developing breast cancer.
Annals of the New York Academy of Sciences 1995;768():327-30.
1995: C A Kristensen; Paul E.G. Kristjansen; Nils Brünner; Robert Clarke; Mogens Spang-Thomsen; Bjørn Quistorff
Effect of estrogen withdrawal on energy-rich phosphates and prediction of estrogen dependence monitored by in vivo 31P magnetic resonance spectroscopy of four human breast cancer xenografts.
Cancer research 1995;55(8):1664-9.
1995: Jesús Ruiz-Cabello; K Berghmans; O Kaplan; Marc Lippman; Robert Clarke; J S Cohen
Hormone dependence of breast cancer cells and the effects of tamoxifen and estrogen: 31P NMR studies.
Breast cancer research and treatment 1995;33(3):209-17.
1994: Leena Hilakivi-Clarke; J Rowland; Robert Clarke; Marc Lippman
Psychosocial factors in the development and progression of breast cancer.
Breast cancer research and treatment 1994;29(2):141-60.
1994: A Zyad; J Bénard; Thomas Tursz; Robert Clarke; Salem Chouaib
Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression.
Cancer research 1994;54(3):825-31.
1994: P Coopman; Marcel Garcia; N Brünner; D Derocq; Robert Clarke; H Rochefort
Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast-cancer cells.
International journal of cancer. Journal international du cancer 1994;56(2):295-300.
1994: F Leonessa; M Jacobson; B Boyle; J Lippman; M McGarvey; Robert Clarke
Effect of tamoxifen on the multidrug-resistant phenotype in human breast cancer cells: isobologram, drug accumulation, and M(r) 170,000 glycoprotein (gp170) binding studies.
Cancer research 1994;54(2):441-7.
1994: Leena Hilakivi-Clarke; Robert Clarke; Marc Lippman
Perinatal factors increase breast cancer risk.
Breast cancer research and treatment 1994;31(2-3):273-84.
1994: Robert Clarke; Todd C Skaar; K Baumann; F Leonessa; M James; J Lippman; Erik W Thompson; CE Freter; N Brunner
Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression.
Breast cancer research and treatment 1994;31(2-3):237-48.
1993: Nils Brünner; T L Frandsen; C Holst-Hansen; M Bei; Erik W Thompson; A E Wakeling; Marc Lippman; Robert Clarke
MCF7/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780.
Cancer research 1993;53(14):3229-32.
1993: Leena Hilakivi-Clarke; P K Arora; Robert Clarke; A Wright; Marc Lippman; R B Dickson
Opposing behavioural alterations in male and female transgenic TGF alpha mice: association with tumour susceptibility.
British journal of cancer 1993;67(5):1026-30.
1993: Nils Brünner; V Boulay; A Fojo; CE Freter; Marc Lippman; Robert Clarke
Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications.
Cancer research 1993;53(2):283-90.
1993: Robert Clarke; Erik W Thompson; F Leonessa; J Lippman; M McGarvey; T L Frandsen; Nils Brünner
Hormone resistance, invasiveness, and metastatic potential in breast cancer.
Breast cancer research and treatment 1993;24(3):227-39.
1993: Erik W Thompson; Nils Brünner; JA Torri; Michael Johnson; V Boulay; A Wright; Marc Lippman; P S Steeg; Robert Clarke
The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells.
Clinical & experimental metastasis 1993;11(1):15-26.
1992: Robert Clarke; S Currier; O Kaplan; E Lovelace; V Boulay; Michael M Gottesman; Robert B Dickson
Effect of P-glycoprotein expression on sensitivity to hormones in MCF-7 human breast cancer cells.
Journal of the National Cancer Institute 1992;84(19):1506-12.
1992: Leena Hilakivi-Clarke; P K Arora; M B Sabol; Robert Clarke; Robert B Dickson; Marc Lippman
Alterations in behavior, steroid hormones and natural killer cell activity in male transgenic TGF alpha mice.
Brain research 1992;588(1):97-103.
1992: Erik W Thompson; Soonmyung Paik; Nils Brünner; C L Sommers; Gerhard Zugmaier; Robert Clarke; T B Shima; JA Torri; S Donahue; Marc Lippman
Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines.
Journal of cellular physiology 1992;150(3):534-44.
1992: L Lehtola; J Partanen; L Sistonen; J Korhonen; A Wärri; P Härkönen; Robert Clarke; Kari Alitalo
Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.
International journal of cancer. Journal international du cancer 1992;50(4):598-603.
1992: F Leonessa; V Boulay; A Wright; Erik W Thompson; Nils Brünner; Robert Clarke
The biology of breast tumor progression. Acquisition of hormone independence and resistance to cytotoxic drugs.
Acta oncologica (Stockholm, Sweden) 1992;31(2):115-23.
1992: Robert Clarke; R B Dickson; Marc Lippman
Hormonal aspects of breast cancer. Growth factors, drugs and stromal interactions.
Critical reviews in oncology/hematology 1992;12(1):1-23.
1992: A Ghiorghis; A Talebian; Robert Clarke
In vitro antineoplastic activity of C7-substituted mitomycin C analogues MC-77 and MC-62 against human breast-cancer cell lines.
Cancer chemotherapy and pharmacology 1992;29(4):290-6.
1992: Nils Brünner; C Moser; Robert Clarke; Kevin J Cullen
IGF-I and IGF-II expression in human breast cancer xenografts: relationship to hormone independence.
Breast cancer research and treatment 1992;22(1):39-45.
1992: T Yano; E Korkut; Jacek Pinski; Karoly Szepeshazi; S Milovanovic; Kate Groot; Robert Clarke; A M Comaru-Schally; Andrew V Schally
Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH.
Breast cancer research and treatment 1992;21(1):35-45.
1991: O Kaplan; J W Jaroszewski; Robert Clarke; C R Fairchild; Patricia V Schoenlein; S Goldenberg; Michael M Gottesman; J S Cohen
The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.
Cancer research 1991;51(6):1638-44.
1990: Robert Clarke; H W van den Berg; R F Murphy
Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol.
Journal of the National Cancer Institute 1990;82(21):1702-5.
1990: Robert Clarke; R B Dickson; N Brünner
The process of malignant progression in human breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1990;1(6):401-7.
1990: Robert Clarke; Marc Lippman; Robert B Dickson
Mechanisms of hormone and cytotoxic drug interactions in the development and treatment of breast cancer.
Progress in clinical and biological research 1990;322():243-78.
1989: Nils Brünner; Gerhard Zugmaier; M Bano; B W Ennis; Robert Clarke; Kevin J Cullen; FG Kern; Robert B Dickson; Marc Lippman
Endocrine therapy of human breast cancer cells: the role of secreted polypeptide growth factors.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1989;1(3):81-6.
1989: Robert Clarke; N Brünner; E W Thompson; P Glanz; D Katz; R B Dickson; Marc Lippman
The inter-relationships between ovarian-independent growth, tumorigenicity, invasiveness and antioestrogen resistance in the malignant progression of human breast cancer.
The Journal of endocrinology 1989;122(1):331-40.
1989: Robert Clarke; Nils Brünner; Benita S Katzenellenbogen; Erik W Thompson; M J Norman; C Koppi; Soonmyung Paik; Marc Lippman; Robert B Dickson
Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3649-53.
1989: Robert Clarke; Nils Brünner; D Katz; P Glanz; Robert B Dickson; Marc Lippman; FG Kern
The effects of a constitutive expression of transforming growth factor-alpha on the growth of MCF-7 human breast cancer cells in vitro and in vivo.
Molecular endocrinology (Baltimore, Md.) 1989;3(2):372-80.
1989: E W Thompson; Mary Beth Martin; Miguel Saceda; Robert Clarke; N Brunner; Marc Lippman; Robert B Dickson
Regulation of breast cancer cells by hormones and growth factors: effects on proliferation and basement membrane invasiveness.
Hormone research 1989;32 Suppl 1():242-9.
1989: Kevin J Cullen; D Yee; Susan E Bates; N Brunner; Robert Clarke; R E Dickson; K K Huff; Soonmyung Paik; Neal Rosen; E Valverius
Regulation of human breast cancer by secreted growth factors.
Acta oncologica (Stockholm, Sweden) 1989;28(6):835-9.
1988: K H Han; James A Ferretti; C H Niu; Vinata B Lokeshwar; Robert Clarke; D Katz
Conformational and receptor binding properties of human EGF and TGF-alpha second loop fragments.
Journal of molecular recognition : JMR 1988;1(3):116-23.
1987: H W van den Berg; W J Leahey; M Lynch; Robert Clarke; J Nelson
Recombinant human interferon alpha increases oestrogen receptor expression in human breast cancer cells (ZR-75-1) and sensitizes them to the anti-proliferative effects of tamoxifen.
British journal of cancer 1987;55(3):255-7.
1986: Robert Clarke; J Morwood; H W van den Berg; J Nelson; R F Murphy
Effect of cytotoxic drugs on estrogen receptor expression and response to tamoxifen in MCF-7 cells.
Cancer research 1986;46(12 Pt 1):6116-9.
1986: J Nelson; Robert Clarke; G R Dickson; H W van den Berg; R F Murphy
The effects of Mg2+ ions or EDTA on nuclear integrity and apparent subcellular distribution of unoccupied oestrogen receptors in breast cancer cells.
Journal of steroid biochemistry 1986;25(5A):619-26.
1986: D G Kennedy; H W Van den Berg; Robert Clarke; R F Murphy
Enhancement of methotrexate cytotoxicity towards the MDA.MB.436 human breast cancer cell line by dipyridamole. The role of methotrexate polyglutamates.
Biochemical pharmacology 1986;35(18):3053-6.
1986: J Nelson; Robert Clarke; R F Murphy
The unoccupied estrogen receptor: some comments on localization.
Steroids 1986;48(1-2):121-4.
1985: D G Kennedy; H W Van den Berg; Robert Clarke; R F Murphy
The effect of the rate of cell proliferation on the synthesis of methotrexate poly-gamma-glutamates in two human breast cancer cell lines.
Biochemical pharmacology 1985;34(17):3087-90.
1985: D G Kennedy; H W Van den Berg; Robert Clarke; R F Murphy
The effect of leucovorin on the synthesis of methotrexate poly-gamma-glutamates in the MCF-7 human breast cancer cell line.
Biochemical pharmacology 1985;34(16):2897-903.
1985: Robert Clarke; H W Van den Berg; D G Kennedy; R F Murphy
Oestrogen receptor status and the response of human breast cancer cell lines to a combination of methotrexate and 17-beta oestradiol.
British journal of cancer 1985;51(3):365-9.
1983: Robert Clarke; H W Van den Berg; D G Kennedy; R F Murphy
Reduction of the anti-metabolic and anti-proliferative effects of methotrexate by 17 beta-oestradiol in a human breast carcinoma cell line, MDA-MB-436.
European journal of cancer & clinical oncology 1983;19(1):19-24.
1983: D G Kennedy; Robert Clarke; H W van den Berg; R F Murphy
The kinetics of methotrexate polyglutamate formation and efflux in a human breast cancer cell line (MDA.MB.436): the effect of insulin.
Biochemical pharmacology 1983;32(1):41-6.
1981: H W Van den Berg; Robert Clarke; R F Murphy
Failure of 5-fluorouracil and methotrexate to destroy the reproductive integrity of a human breast cancer cell line (MCF-7) growing in vitro.
European journal of cancer & clinical oncology 1981;17(12):1275-81.