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Jack Hirsh

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TOP 3
G Guyatt; E Akl; M Crowther; John W Eikelboom; C Francis; D Garcia; M Gould; Elaine M Hylek; S Kahn; R Kunz; D Quinlan; P Vandvik; Jack Hirsh
A response to - There's madness in their methods.
Kyle A Arsenault; Brian Dale; Jeffrey S Ginsberg; Jack Hirsh; Jeremy S Paikin; Kevin Teoh; Jeffrey I Weitz; Richard P Whitlock; Ed Young; John W Eikelboom
Subtle differences in commercial heparins can have serious consequences for cardiopulmonary bypass patients: A randomized controlled trial.
Michiel Coppens; John W Eikelboom; David Gustafsson; Jeffrey I Weitz; Jack Hirsh
Translational success stories: development of direct thrombin inhibitors.

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All Publications

2013: G Guyatt; E Akl; M Crowther; John W Eikelboom; C Francis; D Garcia; M Gould; Elaine M Hylek; S Kahn; R Kunz; D Quinlan; P Vandvik; Jack Hirsh
A response to - There's madness in their methods.
Journal of thrombosis and haemostasis : JTH 2013;11(4):785-6.
2012: Kyle A Arsenault; Brian Dale; Jeffrey S Ginsberg; Jack Hirsh; Jeremy S Paikin; Kevin Teoh; Jeffrey I Weitz; Richard P Whitlock; Ed Young; John W Eikelboom
Subtle differences in commercial heparins can have serious consequences for cardiopulmonary bypass patients: A randomized controlled trial.
The Journal of thoracic and cardiovascular surgery 2012;144(4):944-950.e3.
2012: Michiel Coppens; John W Eikelboom; David Gustafsson; Jeffrey I Weitz; Jack Hirsh
Translational success stories: development of direct thrombin inhibitors.
Circulation research 2012;111(7):920-9.
2012: Chunjian Li; Yan Liang; Jeremy Paikin; Debi Sloane; Jianling Bai; Justin DeBeer; Jack Hirsh; Marilyn A Johnston; John W Eikelboom
Aspirin response variability after major orthopedic surgery.
Thrombosis research 2012;130(2):216-20.
2012: Kyle A Arsenault; Jack Hirsh; Richard P Whitlock; John W Eikelboom
Direct thrombin inhibitors in cardiovascular disease.
Nature reviews. Cardiology 2012;9(7):402-14.
2012: C Li; C Xie; Jack Hirsh; M A Johnston; John W Eikelboom
Reversal of the anti-platelet effects of aspirin and clopidogrel.
Journal of thrombosis and haemostasis : JTH 2012;10(4):521-8.
2012: John W Eikelboom; Jack Hirsh; Frederick A Spencer; Trevor P Baglin; Jeffrey I Weitz
Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest 2012;141(2 Suppl):e89S-119S.
2012: Gordon H Guyatt; Jack Hirsh; Susan R Kahn; Maarten G Lansberg; M Hassan Murad; Elie A Akl; Mark Crowther; John W Eikelboom; Yngve Falck-Ytter; Charles W Francis; David A Garcia; Michael K Gould
Approach to outcome measurement in the prevention of thrombosis in surgical and medical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest 2012;141(2 Suppl):e185S-94S.
2012: Gordon H Guyatt; Jack Hirsh; Sandra Zelman Lewis; Marian S McDonagh; Susan L Norris; Sam Schulman; Holger J Schünemann; Per Olav Vandvik; Elie A Akl; Deborah J Cook; Mark Crowther; Mark H Eckman; John W Eikelboom; David D Gutterman
Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Chest 2012;141(2 Suppl):53S-70S.
2012: M Sobieraj-Teague; T Stokes; G Yip; F Gastaldo; Jack Hirsh; Martin J O'Donnell; D Sloane; John W Eikelboom
Randomized controlled trial of a new portable calf compression device (Venowave) for prevention of venous thrombosis in high-risk neurosurgical patients.
Journal of thrombosis and haemostasis : JTH 2012;10(2):229-35.
2011: Stuart J Connolly; Raffaele De Caterina; John W Eikelboom; Robert Hart; Jack Hirsh; Stefan Hohnloser; Jennifer Ng; Janice Pogue; Salim Yusuf
Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable.
Annals of internal medicine 2011;155(9):579-86.
2010: Petr Klement; Leslie R Berry; Peng Liao; Henry Wood; Paul Tressel; Lesley J Smith; Nihal Haque; Jeffery I Weitz; Jack Hirsh; Nethnapha Paredes; Anthony K C Chan
Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model.
Blood 2010;116(25):5716-23.
2010: Guillaume Paré; Shamir R Mehta; Salim Yusuf; Sonia S Anand; Stuart J Connolly; Jack Hirsh; Katy Simonsen; Deepak L Bhatt; Keith A A Fox; John W Eikelboom
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.
The New England journal of medicine 2010;363(18):1704-14.
2010: Jeremy S Paikin; John W Eikelboom; John A Cairns; Jack Hirsh
New antithrombotic agents--insights from clinical trials.
Nature reviews. Cardiology 2010;7(9):498-509.
2010: Gordon Guyatt; Elie A Akl; Jack Hirsh; Clive Kearon; Mark Crowther; David Gutterman; Sandra Zelman Lewis; Ian Nathanson; Roman Jaeschke; Holger J Schünemann
The vexing problem of guidelines and conflict of interest: a potential solution.
Annals of internal medicine 2010;152(11):738-41.
2010: M Sobieraj-Teague; John W Eikelboom; Jack Hirsh
How can we reduce disagreement among guidelines for venous thromboembolism prevention?
Journal of thrombosis and haemostasis : JTH 2010;8(4):675-7.
2010: J A M Anderson; Jack Hirsh; S Yusuf; Marilyn Johnston; R Afzal; S R Mehta; K A A Fox; A Budaj; John W Eikelboom
Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the Organization to Assess Strategies in Acute Ischemic Syndromes (OASIS)-5 trial.
Journal of thrombosis and haemostasis : JTH 2010;8(2):243-9.
2009: Nina C Raju; Jack Hirsh; John W Eikelboom
Duration of anticoagulant therapy for venous thromboembolism.
The Medical journal of Australia 2009;190(12):659-60.
2009: Ganesan Karthikeyan; John W Eikelboom; Jack Hirsh
New oral anticoagulants: not quite there yet.
Polskie Archiwum Medycyny Wewnętrznej 2009;119(1-2):53-8.
2008: Nina C Raju; John W Eikelboom; Jack Hirsh
Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future.
Nature clinical practice. Cardiovascular medicine 2008;5(12):766-80.
2008: Jeffrey I Weitz; Jack Hirsh; Meyer M Samama
New antithrombotic drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Chest 2008;133(6 Suppl):234S-256S.
2008: John Eikelboom; Gordon Guyatt; Jack Hirsh
Guidelines for anticoagulant use in acute coronary syndromes.
Lancet 2008;371(9624):1559-61.
2008: Martin J O'Donnell; Simon McRae; Susan R Kahn; Jim A Julian; Clive Kearon; Betsy MacKinnon; Debbie Magier; Carla Strulovich; Theresa Lyons; Sandra Robinson; Jack Hirsh; Jeffrey S Ginsberg
Evaluation of a venous-return assist device to treat severe post-thrombotic syndrome (VENOPTS). A randomized controlled trial.
Thrombosis and haemostasis 2008;99(3):623-9.
2007: John W Eikelboom; Jack Hirsh
Combined antiplatelet and anticoagulant therapy: clinical benefits and risks.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():255-63.
2007: Jack Hirsh
Risk of thrombosis with lenalidomide and its prevention with aspirin.
Chest 2007;131(1):275-7.
2006: John W Eikelboom; Jack Hirsh
Monitoring unfractionated heparin with the aPTT: time for a fresh look.
Thrombosis and haemostasis 2006;96(5):547-52.
2006: Clive Kearon; Jeffrey S Ginsberg; Jim A Julian; James D Douketis; Susan Solymoss; Paul Ockelford; Sharon Jackson; Alexander G G Turpie; Betsy MacKinnon; Jack Hirsh; Michael Gent
Comparison of fixed-dose weight-adjusted unfractionated heparin and low-molecular-weight heparin for acute treatment of venous thromboembolism.
JAMA : the journal of the American Medical Association 2006;296(8):935-42.
2006: Jack Hirsh
Vena cava filters reduced long-term risk for pulmonary embolism in proximal deep venous thrombosis.
ACP journal club 2006;144(1):18.
2005: Theodore E Warkentin; Robin S Roberts; Jack Hirsh; John G Kelton
Heparin-induced skin lesions and other unusual sequelae of the heparin-induced thrombocytopenia syndrome: a nested cohort study.
Chest 2005;127(5):1857-61.
2005: Jack Hirsh; Martin O'Donnell; Jeffrey I Weitz
New anticoagulants.
Blood 2005;105(2):453-63.
2004: Shannon M Bates; Ian A Greer; Jack Hirsh; Jeffrey S Ginsberg
Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Chest 2004;126(3 Suppl):627S-644S.
2004: Jeffrey I Weitz; Jack Hirsh; Meyer M Samama
New anticoagulant drugs: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Chest 2004;126(3 Suppl):265S-286S.
2004: Kevin Teoh; Edward Young; Mary-Helen Blackall; Robin S Roberts; Jack Hirsh
Can extra protamine eliminate heparin rebound following cardiopulmonary bypass surgery?
The Journal of thoracic and cardiovascular surgery 2004;128(2):211-9.
2004: Clive Kearon; Jeffrey S Ginsberg; David R Anderson; Michael J Kovacs; Philip Wells; Jim A Julian; Betsy MacKinnon; Christine Demers; James D Douketis; Alexander G G Turpie; Paul van Nguyen; David Green; Jeannine Kassis; Susan R Kahn; Susan Solymoss; L Desjardins; William Geerts; Marilyn Johnston; Jeffrey I Weitz; Jack Hirsh; Michael Gent
Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor.
Journal of thrombosis and haemostasis : JTH 2004;2(5):743-9.
2004: Jack Hirsh; Nancy M Heddle; John G Kelton
Treatment of heparin-induced thrombocytopenia: a critical review.
Archives of internal medicine 2004;164(4):361-9.
2003: Jack Hirsh
Advances and contemporary issues in prophylaxis for deep vein thrombosis.
Chest 2003;124(6 Suppl):347S-348S.
2003: Theodore E Warkentin; Robin S Roberts; Jack Hirsh; John G Kelton
An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients.
Archives of internal medicine 2003;163(20):2518-24.
2003: Mark A Crowther; Jeffrey S Ginsberg; Jim A Julian; Judah A Denburg; Jack Hirsh; James D Douketis; Carl A Laskin; Paul Fortin; David Anderson; Clive Kearon; Ann Clarke; William Geerts; Melissa A Forgie; David Green; Lorrie Costantini; Wendy Yacura; Sarah Wilson; Michael Gent; Michael J Kovacs
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome.
The New England journal of medicine 2003;349(12):1133-8.
2003: Jack Hirsh
Current anticoagulant therapy--unmet clinical needs.
Thrombosis research 2003;109 Suppl 1():S1-8.
2003: Martin O'Donnell; Lori-Ann Linkins; Clive Kearon; Jim A Julian; Jack Hirsh
Reduction of out-of-hospital symptomatic venous thromboembolism by extended thromboprophylaxis with low-molecular-weight heparin following elective hip arthroplasty: a systematic review.
Archives of internal medicine 2003;163(11):1362-6.
2002: Lori-Ann Linkins; Jim A Julian; Janice A Rischke; Jack Hirsh; Jeffrey I Weitz
In vitro comparison of the effect of heparin, enoxaparin and fondaparinux on tests of coagulation.
Thrombosis research 2002;107(5):241-4.
2002: Martin O'Donnell; Jack Hirsh
Review: extended out-of-hospital prophylaxis with heparin prevents deep venous thrombosis in elective hip arthroplasty.
ACP journal club 2002;137(1):11.
2002: Jack Hirsh; Agnes Y Y Lee
How we diagnose and treat deep vein thrombosis.
Blood 2002;99(9):3102-10.
2002: Agnes Y Y Lee; Jack Hirsh
Diagnosis and treatment of venous thromboembolism.
Annual review of medicine 2002;53():15-33.
2001: Jeffrey S Ginsberg; Jack Hirsh; Jim A Julian; M Vander LaandeVries; Deb Magier; Betsy MacKinnon; Michael Gent
Prevention and treatment of postphlebitic syndrome: results of a 3-part study.
Archives of internal medicine 2001;161(17):2105-9.
2001: Jack Hirsh
New anticoagulants.
American heart journal 2001;142(2 Suppl):S3-8.
2001: Clive Kearon; Jeffrey S Ginsberg; James D Douketis; Mark Crowther; Patrick Brill-Edwards; Jeffrey I Weitz; Jack Hirsh
Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing.
Annals of internal medicine 2001;135(2):108-11.
2001: Jack Hirsh; M J O'Donnell
Venous thromboembolism after long flights: are airlines to blame?
Lancet 2001;357(9267):1461-2.
2001: J A Anderson; James C Fredenburgh; Alan R Stafford; Y S Guo; Jack Hirsh; V Ghazarossian; Jeffrey I Weitz
Hypersulfated low molecular weight heparin with reduced affinity for antithrombin acts as an anticoagulant by inhibiting intrinsic tenase and prothrombinase.
The Journal of biological chemistry 2001;276(13):9755-61.
2001: Jack Hirsh; S M Bates
Clinical trials that have influenced the treatment of venous thromboembolism: a historical perspective.
Annals of internal medicine 2001;134(5):409-17.
2001: Mark A Crowther; J Roberts; R Roberts; M Johnston; P Stevens; P Skingley; Giovanni Maurizio Patrassi; Maria Teresa Sartori; Jack Hirsh; Paolo Prandoni; J I Weitz; Michael Gent; J S Ginsberg
Fibrinolytic variables in patients with recurrent venous thrombosis: a prospective cohort study.
Thrombosis and haemostasis 2001;85(3):390-4.
2001: Shannon M Bates; Jeffrey I Weitz; Marilyn Johnston; Jack Hirsh; Jeffrey S Ginsberg
Use of a fixed activated partial thromboplastin time ratio to establish a therapeutic range for unfractionated heparin.
Archives of internal medicine 2001;161(3):385-91.
2000: Patrick Brill-Edwards; Jeffrey S Ginsberg; Michael Gent; Jack Hirsh; R Burrows; Clive Kearon; William Geerts; M Kovacs; Jeffrey I Weitz; K Sue Robinson; R Whittom; G Couture
Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group.
The New England journal of medicine 2000;343(20):1439-44.
2000: Mark A Crowther; Jim A Julian; D McCarty; James D Douketis; M Kovacs; L Biagoni; Terri Schnurr; Joanne A McGinnis; Michael Gent; Jack Hirsh; Jeffrey Ginsberg
Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial.
Lancet 2000;356(9241):1551-3.
2000: Heather M Arthur; C Daniels; R McKelvie; Jack Hirsh; Bonnie Rush
Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. A randomized, controlled trial.
Annals of internal medicine 2000;133(4):253-62.
2000: Jeffrey S Ginsberg; F Turkstra; Harry R Buller; Betsy MacKinnon; Deb Magier; Jack Hirsh
Postthrombotic syndrome after hip or knee arthroplasty: a cross-sectional study.
Archives of internal medicine 2000;160(5):669-72.
2000: Philip S Wells; David R Anderson; Marc A Rodger; Jeffrey S Ginsberg; Clive Kearon; Michael Gent; Alexander G G Turpie; Janis Bormanis; J Weitz; M Chamberlain; D Bowie; D Barnes; Jack Hirsh
Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer.
Thrombosis and haemostasis 2000;83(3):416-20.
1999: Edward Young; Thomas Venner; JC Ribau; Stephen G Shaughnessy; Jack Hirsh; Thomas J Podor
The binding of unfractionated heparin and low molecular weight heparin to thrombin-activated human endothelial cells.
Thrombosis research 1999;96(5):373-81.
1999: Sonia S Anand; S Bates; Jeffrey S Ginsberg; M Levine; Harry R Buller; Martin Prins; Susan Haley; Clive Kearon; Jack Hirsh; Michael Gent
Recurrent venous thrombosis and heparin therapy: an evaluation of the importance of early activated partial thromboplastin times.
Archives of internal medicine 1999;159(17):2029-32.
1999: Jeffrey S Ginsberg; Deb Magier; Betsy MacKinnon; Michael Gent; Jack Hirsh
Intermittent compression units for severe post-phlebitic syndrome: a randomized crossover study.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;160(9):1303-6.
1999: Jack Hirsh; J I Weitz
New antithrombotic agents.
Lancet 1999;353(9162):1431-6.
1999: Clive Kearon; Michael Gent; Jack Hirsh; Jeffrey Weitz; Michael J Kovacs; David R Anderson; Alexander G G Turpie; David Green; Jeffrey S Ginsberg; Philip Wells; Betsy MacKinnon; Jim A Julian
A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.
The New England journal of medicine 1999;340(12):901-7.
1999: Stephen G Shaughnessy; Jack Hirsh; Mohit Bhandari; J M Muir; Edward Young; Jeffrey I Weitz
A histomorphometric evaluation of heparin-induced bone loss after discontinuation of heparin treatment in rats.
Blood 1999;93(4):1231-6.
1999: Jeffrey I Weitz; E Young; Marilyn Johnston; Alan R Stafford; James C Fredenburgh; Jack Hirsh
Vasoflux, a new anticoagulant with a novel mechanism of action.
Circulation 1999;99(5):682-9.
1998: Philip S Wells; Jeffrey S Ginsberg; David R Anderson; Clive Kearon; Michael Gent; Alexander G G Turpie; Janis Bormanis; J Weitz; M Chamberlain; D Bowie; D Barnes; Jack Hirsh
Use of a clinical model for safe management of patients with suspected pulmonary embolism.
Annals of internal medicine 1998;129(12):997-1005.
1998: Clive Kearon; Jeffrey S Ginsberg; Jack Hirsh
The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism.
Annals of internal medicine 1998;129(12):1044-9.
1998: Jeffrey S Ginsberg; Philip S Wells; Clive Kearon; D Anderson; Mark Crowther; Jeffrey I Weitz; Janis Bormanis; Patrick Brill-Edwards; Alexander G G Turpie; Betsy MacKinnon; Michael Gent; Jack Hirsh
Sensitivity and specificity of a rapid whole-blood assay for D-dimer in the diagnosis of pulmonary embolism.
Annals of internal medicine 1998;129(12):1006-11.
1998: Jeffrey S Ginsberg; Jack Hirsh
Use of antithrombotic agents during pregnancy.
Chest 1998;114(5 Suppl):524S-530S.
1998: L Harrison; Joanne A McGinnis; M Crowther; Jeffrey Ginsberg; Jack Hirsh
Assessment of outpatient treatment of deep-vein thrombosis with low-molecular-weight heparin.
Archives of internal medicine 1998;158(18):2001-3.
1998: Anthony K C Chan; Leslie R Berry; Petr Klement; J Julian; Lesley Mitchell; Jeffrey Weitz; Jack Hirsh; Maureen Andrew
A novel antithrombin-heparin covalent complex: antithrombotic and bleeding studies in rabbits.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9(7):587-95.
1998: Mohit Bhandari; Jack Hirsh; Jeffrey I Weitz; Edward Young; Thomas Venner; Stephen G Shaughnessy
The effects of standard and low molecular weight heparin on bone nodule formation in vitro.
Thrombosis and haemostasis 1998;80(3):413-7.
1998: Petr Klement; Peng Liao; Jack Hirsh; Marilyn Johnston; Jeffrey I Weitz
Hirudin causes more bleeding than heparin in a rabbit ear bleeding model.
The Journal of laboratory and clinical medicine 1998;132(3):181-5.
1998: PA Outinen; Sudesh K Sood; Patricia C Y Liaw; K D Sarge; N Maeda; Jack Hirsh; JC Ribau; Thomas J Podor; Jeffrey I Weitz; Richard C Austin
Characterization of the stress-inducing effects of homocysteine.
The Biochemical journal 1998;332 ( Pt 1)():213-21.
1998: R Rajan; Mark Levine; Michael Gent; Jack Hirsh; William Geerts; P Skingley; Jim A Julian
The occurrence of subsequent malignancy in patients presenting with deep vein thrombosis: results from a historical cohort study.
Thrombosis and haemostasis 1998;79(1):19-22.
1997: L Manson; Jeffrey I Weitz; Thomas J Podor; Jack Hirsh; Edward Young
The variable anticoagulant response to unfractionated heparin in vivo reflects binding to plasma proteins rather than clearance.
The Journal of laboratory and clinical medicine 1997;130(6):649-55.
1997: Edward Young; Thomas J Podor; Thomas Venner; Jack Hirsh
Induction of the acute-phase reaction increases heparin-binding proteins in plasma.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(8):1568-74.
1997: Jeffrey S Ginsberg; Clive Kearon; James D Douketis; Alexander G G Turpie; Patrick Brill-Edwards; P Stevens; Akbar Panju; A Patel; Mark Crowther; Maureen Andrew; Patricia Massicotte; Jack Hirsh; Jeffrey I Weitz
The use of D-dimer testing and impedance plethysmographic examination in patients with clinical indications of deep vein thrombosis.
Archives of internal medicine 1997;157(10):1077-81.
1997: Clive Kearon; Jack Hirsh
Management of anticoagulation before and after elective surgery.
The New England journal of medicine 1997;336(21):1506-11.
1997: J M Muir; Jack Hirsh; Jeffrey I Weitz; Maureen Andrew; Edward Young; Stephen G Shaughnessy
A histomorphometric comparison of the effects of heparin and low-molecular-weight heparin on cancellous bone in rats.
Blood 1997;89(9):3236-42.
1997: L Harrison; Marilyn Johnston; M Patricia Massicotte; Mark Crowther; K Moffat; Jack Hirsh
Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy.
Annals of internal medicine 1997;126(2):133-6.
1997: B Cosmi; James C Fredenburgh; Janice A Rischke; Jack Hirsh; E Young; Jeffrey I Weitz
Effect of nonspecific binding to plasma proteins on the antithrombin activities of unfractionated heparin, low-molecular-weight heparin, and dermatan sulfate.
Circulation 1997;95(1):118-24.