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Simon Young

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Simon N Young
Single treatments that have lasting effects: some thoughts on the antidepressant effects of ketamine and botulinum toxin and the anxiolytic effect of psilocybin.
Simon N Young
The effect of raising and lowering tryptophan levels on human mood and social behaviour.
Simon N Young
My 21 years with the Journal of Psychiatry and Neuroscience, with observations on editors, editorial boards, authors and reviewers.

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All Publications

2013: Simon N Young
Single treatments that have lasting effects: some thoughts on the antidepressant effects of ketamine and botulinum toxin and the anxiolytic effect of psilocybin.
Journal of psychiatry & neuroscience : JPN 2013;38(2):78-83.
2013: Simon N Young
The effect of raising and lowering tryptophan levels on human mood and social behaviour.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1615):20110375.
2011: Simon N Young
My 21 years with the Journal of Psychiatry and Neuroscience, with observations on editors, editorial boards, authors and reviewers.
Journal of psychiatry & neuroscience : JPN 2011;36(4):E30-4.
2011: Simon N Young
Biologic effects of mindfulness meditation: growing insights into neurobiologic aspects of the prevention of depression.
Journal of psychiatry & neuroscience : JPN 2011;36(2):75-7.
2011: J J Russell; Debbie S Moskowitz; D C Zuroff; P Bleau; G Pinard; Simon N Young
Anxiety, emotional security and the interpersonal behavior of individuals with social anxiety disorder.
Psychological medicine 2011;41(3):545-54.
2011: Amélie Nantel-Vivier; Sophie Parent; Robert O Pihl; Stacey Ageranioti Bélanger; Marie-Eve Dubois; Rachel Sutton; Richard E Tremblay; Simon N Young; Jean R Séguin
Serotonergic contribution to boys' behavioral regulation.
PloS one 2011;6(6):e20304.
2010: Marije aan het Rot; Nicholas Coupland; Diane B Boivin; Chawki Benkelfat; Simon N Young
Recognizing emotions in faces: effects of acute tryptophan depletion and bright light.
Journal of psychopharmacology (Oxford, England) 2010;24(10):1447-54.
2010: Paul A Newhouse; Julie Dumas; Heather Wilkins; Emily Coderre; Cynthia K Sites; Magdalena Naylor; Chawki Benkelfat; Simon N Young
Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women.
Menopause (New York, N.Y.) 2010;17(4):860-73.
2010: Simon N Young; George N Anderson
Bioanalytical inaccuracy: a threat to the integrity and efficiency of research.
Journal of psychiatry & neuroscience : JPN 2010;35(1):3-6.
2009: Simon N Young
Bias in the research literature and conflict of interest: an issue for publishers, editors, reviewers and authors, and it is not just about the money.
Journal of psychiatry & neuroscience : JPN 2009;34(6):412-7.
2009: Kenneth R Bruce; Howard Steiger; Simon N Young; N M K Ng Ying Kin; Mimi Israël; Mélissa Lévesque
Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women.
Journal of psychiatry & neuroscience : JPN 2009;34(5):376-82.
2009: Peter van Ruitenbeek; Anke Sambeth; Annemiek Vermeeren; Simon N Young; W J Riedel
Effects of L-histidine depletion and L-tyrosine/L-phenylalanine depletion on sensory and motor processes in healthy volunteers.
British journal of pharmacology 2009;157(1):92-103.
2009: Anne-Marie Linnen; Marije aan het Rot; Mark A Ellenbogen; Simon N Young
Interpersonal functioning in adolescent offspring of parents with bipolar disorder.
Journal of affective disorders 2009;114(1-3):122-30.
2009: Simon N Young
Has the time come for clinical trials on the antidepressant effect of vitamin D?
Journal of psychiatry & neuroscience : JPN 2009;34(1):3.
2008: Simon N Young
The neurobiology of human social behaviour: an important but neglected topic.
Journal of psychiatry & neuroscience : JPN 2008;33(5):391-2.
2008: Paul Newhouse; Julie A Dumas; Catherine Hancur-Bucci; Magdalena Naylor; Cynthia K Sites; Chawki Benkelfat; Simon N Young
Estrogen administration negatively alters mood following monoaminergic depletion and psychosocial stress in postmenopausal women.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(7):1514-27.
2008: Marije aan het Rot; Jennifer J Russell; Debbie S Moskowitz; Simon N Young
Alcohol in a social context: findings from event-contingent recording studies of everyday social interactions.
Alcoholism, clinical and experimental research 2008;32(3):459-71.
2008: Maxim D Lewkowski; Simon N Young; Shuvo Ghosh; Blaine Ditto
Effects of opioid blockade on the modulation of pain and mood by sweet taste and blood pressure in young adults.
Pain 2008;135(1-2):75-81.
2008: Marije aan het Rot; Debbie S Moskowitz; Simon N Young
Exposure to bright light is associated with positive social interaction and good mood over short time periods: A naturalistic study in mildly seasonal people.
Journal of psychiatric research 2008;42(4):311-9.
2008: Simon N Young
Journal of Psychiatry and Neuroscience peer review process, with advice for authors.
Journal of psychiatry & neuroscience : JPN 2008;33(1):7-9.
2008: Marije aan het Rot; Chawki Benkelfat; Diane B Boivin; Simon N Young
Bright light exposure during acute tryptophan depletion prevents a lowering of mood in mildly seasonal women.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(1):14-23.
2007: Simon N Young
How to increase serotonin in the human brain without drugs.
Journal of psychiatry & neuroscience : JPN 2007;32(6):394-9.
2007: Simon N Young
Folate and depression--a neglected problem.
Journal of psychiatry & neuroscience : JPN 2007;32(2):80-2.
2006: Y Sakai; M Nishikawa; Marco Leyton; Chawki Benkelfat; Simon N Young; Mirko Diksic
Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males.
NeuroImage 2006;33(3):815-24.
2006: Pamela Horne; Ronald G Barr; Grace Valiante; Philip R Zelazo; Simon N Young
Glucose enhances newborn memory for spoken words.
Developmental psychobiology 2006;48(7):574-82.
2006: Howard Steiger; Lise Gauvin; Ridha Joober; Mimi Israel; N M K Ng Ying Kin; Kenneth R Bruce; Jodie Richardson; Simon N Young; Julie Hakim
Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(8):1785-92.
2006: Marije aan het Rot; Debbie S Moskowitz; Gilbert Pinard; Simon N Young
Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals.
Journal of psychiatry & neuroscience : JPN 2006;31(4):253-62.
2006: Simon N Young
A rant against jargon and neologisms.
Journal of psychiatry & neuroscience : JPN 2006;31(3):155-6.
2006: Alexandre Berney; Debbie Sookman; Marco Leyton; Simon N Young; Chawki Benkelfat
Lack of effects on core obsessive-compulsive symptoms of tryptophan depletion during symptom provocation in remitted obsessive-compulsive disorder patients.
Biological psychiatry 2006;59(9):853-7.
2006: A Grace Valiante; Ronald G Barr; Philip R Zelazo; Apostolos N Papageorgiou; Simon N Young
A typical feeding enhances memory for spoken words in healthy 2- to 3-day-old newborns.
Pediatrics 2006;117(3):e476-86.
2006: Debbie S Moskowitz; Simon N Young
Ecological momentary assessment: what it is and why it is a method of the future in clinical psychopharmacology.
Journal of psychiatry & neuroscience : JPN 2006;31(1):13-20.
2005: M Nishikawa; Yoshikata Kumakura; Simon N Young; Pierre-Olivier Fiset; N Vogelzangs; Marco Leyton; Chawki Benkelfat; Mirko Diksic
Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-L-tryptophan and positron emission tomography.
Neurochemistry international 2005;47(8):556-64.
2005: Ronald G Barr; Jodi A Paterson; Lisa M MacMartin; Liisa Lehtonen; Simon N Young
Prolonged and unsoothable crying bouts in infants with and without colic.
Journal of developmental and behavioral pediatrics : JDBP 2005;26(1):14-23.
2005: Howard Steiger; Ridha Joober; Mimi Israël; Simon N Young; N M K Ng Ying Kin; Lise Gauvin; Kenneth R Bruce; Jasmine Joncas; Adam Torkaman-Zehi
The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes.
The International journal of eating disorders 2005;37(1):57-60.
2005: Simon N Young; Marjan Shalchi
The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain.
Journal of psychiatry & neuroscience : JPN 2005;30(1):44-8.
2004: Simon N Young; Russell T Joffe
Ethical conduct of journal editors.
Journal of psychiatry & neuroscience : JPN 2004;29(5):334-6.
2004: Howard Steiger; Lise Gauvin; Mimi Israël; N M K Ng Ying Kin; Simon N Young; Julie Roussin
Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders.
The Journal of clinical psychiatry 2004;65(6):830-7.
2004: Marco Leyton; Alain Dagher; Isabelle Boileau; Kevin F Casey; Glen B Baker; Mirko Diksic; Roger Gunn; Simon N Young; Chawki Benkelfat
Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(2):427-32.
2004: Kenneth R Bruce; Howard Steiger; Naomi M Koerner; Mimi Israel; Simon N Young
Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function.
Psychological medicine 2004;34(1):113-24.
2003: Marco Leyton; Valerie Kwai Pun; Chawki Benkelfat; Simon N Young
A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humans.
Journal of psychiatry & neuroscience : JPN 2003;28(6):464-7.
2003: Maxim D Lewkowski; Blaine Ditto; Marios Roussos; Simon N Young
Sweet taste and blood pressure-related analgesia.
Pain 2003;106(1-2):181-6.
2003: Howard Steiger; Mimi Israël; Lise Gauvin; N M K Ng Ying Kin; Simon N Young
Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa.
Psychiatry research 2003;120(3):219-29.
2003: Simon N Young
Peer review of manuscripts: theory and practice.
Journal of psychiatry & neuroscience : JPN 2003;28(5):327-30.
2003: M D Lewkowski; Ronald G Barr; Adam Sherrard; J Lessard; A R Harris; Simon N Young
Effects of chewing gum on responses to routine painful procedures in children.
Physiology & behavior 2003;79(2):257-65.
2003: Simon N Young
Lifestyle drugs, mood, behaviour and cognition.
Journal of psychiatry & neuroscience : JPN 2003;28(2):87-9.
2003: Mary Perugini; Colleen Mahoney; Vadim Ilivitsky; Simon N Young; Verner J Knott
Effects of tryptophan depletion on acute smoking abstinence symptoms and the acute smoking response.
Pharmacology, biochemistry, and behavior 2003;74(3):513-22.
2002: Simon N Young; Lawrence Annable
The ethics of placebo in clinical psychopharmacology: the urgent need for consistent regulation.
Journal of psychiatry & neuroscience : JPN 2002;27(5):319-21.
2002: Pierre Blier; Bernard Seletti; Francois Gilbert; Simon N Young; Chawki Benkelfat
Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(2):301-8.
2002: Simon N Young; Marco Leyton
The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels.
Pharmacology, biochemistry, and behavior 2002;71(4):857-65.
2002: Simon N Young
Clinical nutrition: 3. The fuzzy boundary between nutrition and psychopharmacology.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2002;166(2):205-9.
2001: Mirko Diksic; Simon N Young
Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan.
Journal of neurochemistry 2001;78(6):1185-200.
2001: Howard Steiger; Lise Gauvin; Mimi Israël; Naomi M Koerner; N M K Ng Ying Kin; Joel Paris; Simon N Young
Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa.
Archives of general psychiatry 2001;58(9):837-43.
2001: Debbie S Moskowitz; Gilbert Pinard; David C Zuroff; Lawrence Annable; Simon N Young
The effect of tryptophan on social interaction in everyday life: a placebo-controlled study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(2):277-89.
2001: MI Botez; Simon N Young
Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2001;28(2):134-40.
2001: Marco Leyton; Hidehiko Okazawa; Mirko Diksic; Joel Paris; Pedro Rosa-Neto; MZENGEZA SHADRECK; Simon N Young; Pierre Blier; Chawki Benkelfat
Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder.
The American journal of psychiatry 2001;158(5):775-82.
2001: S Gormally; Ronald G Barr; L Wertheim; R Alkawaf; N Calinoiu; Simon N Young
Contact and nutrient caregiving effects on newborn infant pain responses.
Developmental medicine and child neurology 2001;43(1):28-38.
2001: Howard Steiger; Simon N Young; N M K Ng Ying Kin; Naomi M Koerner; Mimi Israel; P Lageix; Joel Paris
Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa.
Psychological medicine 2001;31(1):85-95.
2000: Howard Steiger; S Léonard; N Y Kin; C Ladouceur; D Ramdoyal; Simon N Young
Childhood abuse and platelet tritiated-paroxetine binding in bulimia nervosa: implications of borderline personality disorder.
The Journal of clinical psychiatry 2000;61(6):428-35.
2000: Marco Leyton; Simon N Young; P Blier; G B Baker; Robert O Pihl; Chawki Benkelfat
Acute tyrosine depletion and alcohol ingestion in healthy women.
Alcoholism, clinical and experimental research 2000;24(4):459-64.
2000: Marco Leyton; Abdu'l-Missagh Ghadirian; Simon N Young; Roberta Palmour; Pierre Blier; KF Helmers; Chawki Benkelfat
Depressive relapse following acute tryptophan depletion in patients with major depressive disorder.
Journal of psychopharmacology (Oxford, England) 2000;14(3):284-7.
2000: Marco Leyton; Simon N Young; Robert O Pihl; S Etezadi; C Lauze; Pierre Blier; Glen B Baker; Chawki Benkelfat
Effects on mood of acute phenylalanine/tyrosine depletion in healthy women.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(1):52-63.
1999: DG LeMarquand; Chawki Benkelfat; Robert O Pihl; Roberta Palmour; Simon N Young
Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism.
The American journal of psychiatry 1999;156(11):1771-9.
1999: Verner J Knott; A L Howson; M Perugini; Arun V Ravindran; Simon N Young
The effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects.
Biological psychiatry 1999;46(2):229-38.
1999: Chawki Benkelfat; Simon N Young; H Okazawa; Marco Leyton; Mirko Diksic
The validity of the PET/alpha-[11C]methyl-L-tryptophan method for measuring rates of serotonin synthesis in the human brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(1):153-7.
1999: Ronald G Barr; M S Pantel; Simon N Young; JH Wright; L A Hendricks; R Gravel
The response of crying newborns to sucrose: is it a "sweetness" effect?
Physiology & behavior 1999;66(3):409-17.
1999: Ronald G Barr; Simon N Young; JH Wright; R Gravel; R Alkawaf
Differential calming responses to sucrose taste in crying infants with and without colic.
Pediatrics 1999;103(5):e68.
1999: S Steinberg; Lawrence Annable; Simon N Young; N Liyanage
A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria.
Biological psychiatry 1999;45(3):313-20.
1999: Marco Leyton; Simon N Young; Robert O Pihl; S Etezadi; C Lauze; P Blier; G B Baker; Chawki Benkelfat
A comparison of the effects of acute tryptophan depletion and acute phenylalanine/tyrosine depletion in healthy women.
Advances in experimental medicine and biology 1999;467():67-71.
1999: M A Ellenbogen; Simon N Young; P Dean; Roberta Palmour; Chawki Benkelfat
Acute tryptophan depletion in healthy young women with a family history of major affective disorder.
Psychological medicine 1999;29(1):35-46.
1998: Javier F Burchard; Duc Hai Nguyen; L Richard; Simon N Young; M P Heyes; E Block
Effects of electromagnetic fields on the levels of biogenic amine metabolites, quinolinic acid, and beta-endorphin in the cerebrospinal fluid of dairy cows.
Neurochemical research 1998;23(12):1527-31.
1998: KF Helmers; Simon N Young
The effect of sucrose on acute tobacco withdrawal in women.
Psychopharmacology 1998;139(3):217-21.
1998: DG LeMarquand; Robert O Pihl; Simon N Young; Richard E Tremblay; Jean R Séguin; Roberta Palmour; Chawki Benkelfat
Tryptophan depletion, executive functions, and disinhibition in aggressive, adolescent males.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(4):333-41.
1998: Roberta Palmour; Frank R Ervin; Glen B Baker; Simon N Young
An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys.
Psychopharmacology 1998;136(1):1-7.
1997: KF Helmers; DS Danoff; Yvonne Steinert; Marco Leyton; Simon N Young
Stress and depressed mood in medical students, law students, and graduate students at McGill University.
Academic medicine : journal of the Association of American Medical Colleges 1997;72(8):708-14.
1997: A Graillon; Ronald G Barr; Simon N Young; JH Wright; L A Hendricks
Differential response to intraoral sucrose, quinine and corn oil in crying human newborns.
Physiology & behavior 1997;62(2):317-25.
1997: Marco Leyton; Simon N Young; C Benkelfat
Relapse of depression after rapid depletion of tryptophan.
Lancet 1997;349(9068):1840-1.
1997: S Nishizawa; Chawki Benkelfat; Simon N Young; Marco Leyton; MZENGEZA SHADRECK; Claude de Montigny; Pierre Blier; Mirko Diksic
Differences between males and females in rates of serotonin synthesis in human brain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5308-13.
1997: Marco Leyton; Simon N Young; Pierre Blier; M A Ellenbogen; Roberta Palmour; Abdu'l-Missagh Ghadirian; Chawki Benkelfat
The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(4):294-7.
1996: M A Ellenbogen; Simon N Young; P Dean; Roberta Palmour; Chawki Benkelfat
Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(5):465-74.
1996: Diana Koszycki; Robert M Zacharko; J M Le Melledo; Simon N Young; Jacques Bradwejn
Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers.
Biological psychiatry 1996;40(7):648-55.
1996: Simon N Young; Lawrence Annable
The use of placebos in psychiatry: a response to the draft document prepared by the Tri-Council Working Group. Canadian College of Neuropsychopharmacology.
Journal of psychiatry & neuroscience : JPN 1996;21(4):235-8.
1996: Deborah C Mash; J K Staley; F M Doepel; Simon N Young; F R Ervin; Roberta Palmour
Altered dopamine transporter densities in alcohol-preferring vervet monkeys.
Neuroreport 1996;7(2):457-62.
1996: Simon N Young
Behavioral effects of dietary neurotransmitter precursors: basic and clinical aspects.
Neuroscience and biobehavioral reviews 1996;20(2):313-23.
1995: Ronald G Barr; Simon N Young; J H Wright; K L Cassidy; L Hendricks; Y Bedard; J Yaremko; D Leduc; S Treherne
"Sucrose analgesia" and diphtheria-tetanus-pertussis immunizations at 2 and 4 months.
Journal of developmental and behavioral pediatrics : JDBP 1995;16(4):220-5.
1995: Robert O Pihl; Simon N Young; P Harden; S Plotnick; B Chamberlain; F R Ervin
Acute effect of altered tryptophan levels and alcohol on aggression in normal human males.
Psychopharmacology 1995;119(4):353-60.
1995: Chawki Benkelfat; B Seletti; Roberta Palmour; J Hillel; M Ellenbogen; Simon N Young
Tryptophan depletion in stable lithium-treated patients with bipolar disorder in remission.
Archives of general psychiatry 1995;52(2):154-6.
1995: Kristine G Koski; L Lanoue; Simon N Young
Maternal dietary carbohydrate restriction influences the developmental profile of postnatal rat brain indoleamine metabolism.
Biology of the neonate 1995;67(2):122-31.
1994: Chawki Benkelfat; M A Ellenbogen; P Dean; Roberta Palmour; Simon N Young
Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders.
Archives of general psychiatry 1994;51(9):687-97.
1994: Ronald G Barr; V S Quek; D Cousineau; T F Oberlander; J A Brian; Simon N Young
Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants.
Developmental medicine and child neurology 1994;36(7):608-18.
1994: A Miller; Ronald Barr; Simon N Young
The cold pressor test in children: methodological aspects and the analgesic effect of intraoral sucrose.
Pain 1994;56(2):175-83.
1993: Simon N Young
The use of diet and dietary components in the study of factors controlling affect in humans: a review.
Journal of psychiatry & neuroscience : JPN 1993;18(5):235-44.
1993: Kristine G Koski; L Lanoue; Simon N Young
Restriction of maternal dietary carbohydrate decreases fetal brain indoles and glycogen in rats.
The Journal of nutrition 1993;123(1):42-51.
1992: T F Oberlander; Ronald G Barr; Simon N Young; J A Brian
Short-term effects of feed composition on sleeping and crying in newborns.
Pediatrics 1992;90(5):733-40.
1992: Frances V Abbott; P Etienne; Keith B J Franklin; M J Morgan; M J Sewitch; Simon N Young
Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans.
Psychopharmacology 1992;108(1-2):60-6.
1991: Simon N Young
Use of tryptophan in combination with other antidepressant treatments: a review.
Journal of psychiatry & neuroscience : JPN 1991;16(5):241-6.
1991: Frances V Abbott; Simon N Young
The effect of tryptophan supplementation on autotomy induced by nerve lesions in rats.
Pharmacology, biochemistry, and behavior 1991;40(2):301-4.
1991: MI Botez; Simon N Young; T Botez; O L Pedraza
Treatment of heredo-degenerative ataxias with amantadine hydrochloride.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3):307-11.
1991: Simon N Young
The 1989 Borden Award Lecture. Some effects of dietary components (amino acids, carbohydrate, folic acid) on brain serotonin synthesis, mood, and behavior.
Canadian journal of physiology and pharmacology 1991;69(7):893-903.
1991: M I Botez; Simon N Young
Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.
Brain : a journal of neurology 1991;114 ( Pt 1A)():333-48.
1991: C Zacchia; Robert O Pihl; Simon N Young; F R Ervin
Effect of sucrose consumption on alcohol-induced impairment in male social drinkers.
Psychopharmacology 1991;105(1):49-56.
1991: Simon N Young
Acute effects of meals on brain tryptophan and serotonin in humans.
Advances in experimental medicine and biology 1991;294():417-23.
1990: F R Ervin; Roberta Palmour; Simon N Young; C Guzman-Flores; J Juarez
Voluntary consumption of beverage alcohol by vervet monkeys: population screening, descriptive behavior and biochemical measures.
Pharmacology, biochemistry, and behavior 1990;36(2):367-73.
1990: Keith B J Franklin; Frances V Abbott; M J English; M E Jeans; R A Tasker; Simon N Young
Tryptophan-morphine interactions and postoperative pain.
Pharmacology, biochemistry, and behavior 1990;35(1):157-63.
1989: K L Teff; Simon N Young; J E Blundell
The effect of protein or carbohydrate breakfasts on subsequent plasma amino acid levels, satiety and nutrient selection in normal males.
Pharmacology, biochemistry, and behavior 1989;34(4):829-37.
1989: M I Botez; Simon N Young; T Rotez; Y Courchesne
Treatment of Friedreich's ataxia with amantadine.
Neurology 1989;39(5):749-50.
1989: Simon N Young; Abdu'l-Missagh Ghadirian
Folic acid and psychopathology.
Progress in neuro-psychopharmacology & biological psychiatry 1989;13(6):841-63.
1989: Simon N Young; K L Teff
Tryptophan availability, 5HT synthesis and 5HT function.
Progress in neuro-psychopharmacology & biological psychiatry 1989;13(3-4):373-9.
1989: Simon N Young; F R Ervin; Robert O Pihl; P Finn
Biochemical aspects of tryptophan depletion in primates.
Psychopharmacology 1989;98(4):508-11.
1989: K L Teff; Simon N Young; Lyne Marchand; MI Botez
Acute effect of protein or carbohydrate breakfasts on human cerebrospinal fluid monoamine precursor and metabolite levels.
Journal of neurochemistry 1989;52(1):235-41.
1988: Frances V Abbott; Simon N Young
Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test.
Pharmacology, biochemistry, and behavior 1988;31(4):855-60.
1988: Simon N Young; S V Tourjman; K L Teff; Robert O Pihl; G H Anderson
The effect of lowering plasma tryptophan on food selection in normal males.
Pharmacology, biochemistry, and behavior 1988;31(1):149-52.
1988: K L Teff; Simon N Young
Effects of carbohydrate and protein administration on rat tryptophan and 5-hydroxytryptamine: differential effects on the brain, intestine, pineal, and pancreas.
Canadian journal of physiology and pharmacology 1988;66(6):683-8.
1988: A S Boal; Simon N Young; M Sutherland; F R Ervin; R Coppinger
The effect of breakfast on social behavior and brain amine metabolism in vervet monkeys.
Pharmacology, biochemistry, and behavior 1988;29(1):115-23.
1987: B Chamberlain; F R Ervin; Robert O Pihl; Simon N Young
The effect of raising or lowering tryptophan levels on aggression in vervet monkeys.
Pharmacology, biochemistry, and behavior 1987;28(4):503-10.
1987: G M Anderson; K L Teff; Simon N Young
Serotonin in cisternal cerebrospinal fluid of the rat: measurement and use as an index of functionally active serotonin.
Life sciences 1987;40(23):2253-60.
1987: Robert O Pihl; Simon N Young; F R Ervin; S Plotnick
Influence of tryptophan availability on selection of alcohol and water by men.
Journal of studies on alcohol 1987;48(3):260-4.
1987: S E Smith; R O Pihl; Simon N Young; F R Ervin
A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males.
Psychopharmacology 1987;91(4):451-7.
1986: J B Martin; R O Pihl; Simon N Young; F R Ervin; S V Tourjman
Prediction of alexithymic characteristics from physiological, personality, and subjective measures.
Psychotherapy and psychosomatics 1986;45(3):133-40.
1986: R R Dent; A M Ghadirian; M Kusalic; Simon N Young
Diurnal rhythms of plasma cortisol, beta-endorphin and prolactin, and cerebrospinal fluid amine metabolite levels before suicide. Case report.
Neuropsychobiology 1986;16(2-3):64-7.
1985: G Chouinard; Simon N Young; L Annable
A controlled clinical trial of L-tryptophan in acute mania.
Biological psychiatry 1985;20(5):546-57.
1985: J Montplaisir; R Godbout; D Boghen; J DeChamplain; Simon N Young; G Lapierre
Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study.
Neurology 1985;35(1):130-4.
1985: Simon N Young; S E Smith; R O Pihl; F R Ervin
Tryptophan depletion causes a rapid lowering of mood in normal males.
Psychopharmacology 1985;87(2):173-7.
1984: Simon N Young; S Gauthier; M E Kiely; S Lal; G M Brown
Effect of oral melatonin administration on melatonin, 5-hydroxyindoleacetic acid, indoleacetic acid, and cyclic nucleotides in human cerebrospinal fluid.
Neuroendocrinology 1984;39(1):87-92.
1984: Simon N Young; F R Ervin
Cerebrospinal fluid measurements suggest precursor availability and sex are involved in the control of biogenic amine metabolism in a primate.
Journal of neurochemistry 1984;42(6):1570-3.
1983: C Morand; Simon N Young; F R Ervin
Clinical response of aggressive schizophrenics to oral tryptophan.
Biological psychiatry 1983;18(5):575-8.
1983: G Chouinard; Simon N Young; L Annable
Antimanic effect of clonazepam.
Biological psychiatry 1983;18(4):451-66.
1983: Simon N Young; M H Joseph; S Gauthier
Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.
Journal of neural transmission 1983;58(3-4):193-204.
1982: Simon N Young; G M Anderson
Factors influencing melatonin, 5-hydroxytryptophol, 5-hydroxyindoleacetic acid, 5-hydroxytryptamine and tryptophan in rat pineal glands.
Neuroendocrinology 1982;35(6):464-8.
1982: J Montplaisir; J de Champlain; Simon N Young; K Missala; T L Sourkes; J Walsh; G Rémillard
Narcolepsy and idiopthic hypersomnia: biogenic amines and related compounds in CSF.
Neurology 1982;32(11):1299-302.
1982: M I Botez; Simon N Young; J Bachevalier; S Gauthier
Effect of folic acid and vitamin B12 deficiencies on 5-hydroxyindoleacetic acid in human cerebrospinal fluid.
Annals of neurology 1982;12(5):479-84.
1982: M I Botez; Simon N Young; J Bachevalier; S Gauthier
Thiamine deficiency and cerebrospinal fluid 5-hydroxyindoleacetic acid: a preliminary study.
Journal of neurology, neurosurgery, and psychiatry 1982;45(8):731-3.
1982: Simon N Young; B A Davis; S Gauthier
Precursors and metabolites of phenylethylamine, m and p-tyramine and tryptamine in human lumbar and cisternal cerebrospinal fluid.
Journal of neurology, neurosurgery, and psychiatry 1982;45(7):633-9.
1982: G M Anderson; J G Young; D J Cohen; Simon N Young
Determination of indoles in human and rat pineal.
Journal of chromatography 1982;228():155-63.
1982: C J Gibson; S M Deikel; Simon N Young; Y M Binik
Behavioural and biochemical effects of tryptophan, tyrosine and phenylalanine in mice.
Psychopharmacology 1982;76(2):118-21.
1982: Simon N Young; S Gauthier; G Chouinard; G M Anderson; W C Purdy
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
Journal of neural transmission 1982;53(1):83-7.
1981: Simon N Young
Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis.
British journal of pharmacology 1981;74(3):695-700.
1981: S Lal; Simon N Young; M E Kiely; K Hoyte; D W Baxter; T L Sourkes
Effect of L-tryptophan on spasmodic torticollis.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1981;8(4):305-8.
1981: G M Anderson; J G Young; D K Batter; Simon N Young; D J Cohen; B A Shaywitz
Determination of indoles and catechols in rat brain and pineal using liquid chromatography with fluorometric and amperometric detection.
Journal of chromatography 1981;223(2):315-20.
1981: Simon N Young; S Gauthier
Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid.
Journal of neurology, neurosurgery, and psychiatry 1981;44(4):323-8.
1981: S Gauthier; Simon N Young; D W Baxter
[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam].
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1981;8(1):51-4.
1981: S F Pang; G M Brown; S L Campbell; V Snieckas; S O de Silva; Simon N Young; L J Grota
A radioimmunoassay for N-acetylserotonin in biological tissues.
Journal of immunoassay 1981;2(3-4):263-76.
1980: S Lal; Simon N Young; P Cervantes; H Guyda
Effect of L-tryptophan on apomorphine-induced growth hormone secretion in normal subjects.
Pharmakopsychiatrie, Neuro-Psychopharmakologie 1980;13(6):331-5.
1980: E M Sternberg; M H Van Woert; Simon N Young; I Magnussen; H Baker; S Gauthier; C K Osterland
Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
The New England journal of medicine 1980;303(14):782-7.
1980: S Franks; J McElhone; Simon N Young; I Kraulis; K B Ruf
Factors determining the diurnal variation in progesterone-induced gonadotropin release in the ovariectomized rat.
Endocrinology 1980;107(1):353-8.
1980: Simon N Young; S Gauthier; G M Anderson; W C Purdy
Tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human cerebrospinal fluid: interrelationships and the influence of age, sex, epilepsy and anticonvulsant drugs.
Journal of neurology, neurosurgery, and psychiatry 1980;43(5):438-45.
1980: Simon N Young; G M Anderson; S Gauthier; W C Purdy
The origin of indoleacetic acid and indolepropionic acid in rat and human cerebrospinal fluid.
Journal of neurochemistry 1980;34(5):1087-92.
1980: Simon N Young; G M Anderson; W C Purdy
Indoleamine metabolism in rat brain studied through measurements of tryptophan, 5-hydroxyindoleacetic acid, and indoleacetic acid in cerebrospinal fluid.
Journal of neurochemistry 1980;34(2):309-15.
1980: Simon N Young; S Lal
CNS tryptamine metabolism in hepatic coma.
Journal of neural transmission 1980;47(3):153-61.
1979: G M Brown; Simon N Young; S Gauthier; H Tsui; L J Grota
Melatonin in human cerebrospinal fluid in daytime; its origin and variation with age.
Life sciences 1979;25(11):929-36.
1979: K D Laxer; T L Sourkes; T Y Fang; Simon N Young; S Gauthier; K Missala
Monoamine metabolites in the CSF of epileptic patients.
Neurology 1979;29(8):1157-61.
1979: Simon N Young; M Oravec
The effect of growth hormone on the metabolism of a tryptophan load in the liver and brain of hypophysectomized rats.
Canadian journal of biochemistry 1979;57(6):517-22.
1979: G Chouinard; B D Jones; Simon N Young; L Annable
Potentiation of lithium by tryptophan in a patient with bipolar illness.
The American journal of psychiatry 1979;136(5):719-20.
1979: G Chouinard; Simon N Young; L Annable; T L Sourkes
Tryptophan-nicotinamide, imipramine and their combination in depression. A controlled study.
Acta psychiatrica Scandinavica 1979;59(4):395-414.
1979: M I Botez; Simon N Young; J Bachevalier; S Gauthier
Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat.
Nature 1979;278(5700):182-3.
1979: Simon N Young
Treatment of mental disorders.
Science (New York, N.Y.) 1979;203(4383):834.
1978: Simon N Young; D St-Arnaud-McKenzie; T L Sourkes
Importance of tryptophan pyrrolase and aromatic amino acid decarboxylase in the catabolism of tryptophan.
Biochemical pharmacology 1978;27(5):763-7.
1978: G Chouinard; Simon N Young; L Annable; T L Sourkes; R Z Kiriakos
Tryptophan-nicotinamide combination in the treatment of newly admitted depressed patients.
Communications in psychopharmacology 1978;2(4):311-7.
1977: Simon N Young; D Tsang; S Lal; T L Sourkes
Changes in the tryptophan content of excised human cerebral cortex.
Journal of neurochemistry 1977;28(2):439-40.
1976: M H Joseph; Simon N Young; G Curzon
The metabolism of a tryptophan load in rat brain and liver. The influence of hydrocortisone and allopurinol.
Biochemical pharmacology 1976;25(23):2599-604.
1976: Simon N Young; P Etienne; T L Sourkes
Relationship between rat brain and cisternal CSF tryptophan concentrations.
Journal of neurology, neurosurgery, and psychiatry 1976;39(3):239-43.
1976: Simon N Young; S Lal; F Feldmuller; T L Sourkes; R M Ford; M Kiely; J B Martin
Parallel variation of ventricular CSF tryptophan and free serum tryptophan in man.
Journal of neurology, neurosurgery, and psychiatry 1976;39(1):61-5.
1975: S Lal; A Aronoff; E Garelis; T L Sourkes; Simon N Young; C E de la Vega
Cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid, lactic acid, and pH before and after probenecid in hepatic coma.
Clinical neurology and neurosurgery 1975;77(2):142-52.
1975: S Lal; Simon N Young; T L Sourkes
Letter: 5-hydroxytryptamine and hepatic coma.
Lancet 1975;2(7942):979-80.
1975: Simon N Young; T L Sourkes
Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.
The Journal of biological chemistry 1975;250(13):5009-14.
1975: Simon N Young; S Lal; T L Sourkes; F Feldmuller; A Aronoff; J B Martin
Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.
Journal of neurology, neurosurgery, and psychiatry 1975;38(4):322-30.
1975: A R Green; T L Sourkes; Simon N Young
Liver and brain tryptophan metabolism following hydrocortisone administration to rats and gerbils.
British journal of pharmacology 1975;53(2):287-92.