FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Lawrence Stern

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Phenomena

Protein Binding

Physiology

Anatomy

Procedures

X Ray Crystallography

Co-author Network

Publications

TOP 3
efstratios stratikos; Lawrence J Stern
Antigenic peptide trimming by ER aminopeptidases-Insights from structural studies.
Abigail I Guce; Wei Jiang; Elizabeth D Mellins; Sarah E Mortimer; Corrie A Painter; Taejin Yoon; Lawrence J Stern
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Corrie A Painter; Lawrence J Stern
Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Lawrence Stern (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: efstratios stratikos; Lawrence J Stern
Antigenic peptide trimming by ER aminopeptidases-Insights from structural studies.
Molecular immunology 2013;55(3-4):212-9.
2013: Abigail I Guce; Wei Jiang; Elizabeth D Mellins; Sarah E Mortimer; Corrie A Painter; Taejin Yoon; Lawrence J Stern
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Nature structural & molecular biology 2013;20(1):90-8.
2012: Corrie A Painter; Lawrence J Stern
Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.
Immunological reviews 2012;250(1):144-57.
2012: Diego J Farfán-Arribas; Lawrence J Stern; Kenneth L Rock
Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16998-7003.
2012: Liusong Yin; J Mauricio Calvo-Calle; Omar Dominguez-Amorocho; Lawrence J Stern
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3983-94.
2012: Maria-D Nastke; Lawrence J Stern; Liusong Yin; Aniuska Becerra; Omar Dominguez-Amorocho; Laura Gibson; J Mauricio Calvo-Calle
Human CD4+ T cell response to human herpesvirus 6.
Journal of virology 2012;86(9):4776-92.
2012: Christopher J Holland; Florian Madura; Pierre J Rizkallah; Andrew K Sewell; Lawrence J Stern; Sabrina Vollers; J Mauricio Calvo-Calle; Anna Fuller; Andrew Godkin; David K Cole
Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.
Scientific reports 2012;2():629.
2011: Corrie A Painter; James E Evans; Katherine A Kellersberger; Maria P Negroni; Zarixia Zavala-Ruiz; Lawrence J Stern
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19329-34.
2011: Tina T Nguyen; Shih-Chung Chang; Irini Evnouchidou; Ian A York; Christos Zikos; Kenneth L Rock; Alfred L Goldberg; efstratios stratikos; Lawrence J Stern
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.
Nature structural & molecular biology 2011;18(5):604-13.
2010: Zu T Shen; Michael A Brehm; Keith A Daniels; Alexander B Sigalov; Liisa K Selin; Raymond M Welsh; Lawrence J Stern
Bi-specific MHC heterodimers for characterization of cross-reactive T cells.
The Journal of biological chemistry 2010;285(43):33144-53.
2010: Walter M Kim; Alexander B Sigalov; Lawrence J Stern
Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):163-75.
2010: Cristina Clement; Elvira S Cannizzo; Maria-Dorothea Nastke; Ranjit Sahu; Waldemar Olszewski; Norman E Miller; Lawrence J Stern; Laura Santambrogio
An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma.
PloS one 2010;5(3):e9863.
2009: Lawrence J Stern; J Mauricio Calvo-Calle
HLA-DR: molecular insights and vaccine design.
Current pharmaceutical design 2009;15(28):3249-61.
2008: Alexander B Sigalov; Walter M Kim; Maria Saline; Lawrence J Stern
The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition.
Biochemistry 2008;47(49):12942-4.
2008: Iwona Strug; J Mauricio Calvo-Calle; Karin M Green; John Cruz; Francis A Ennis; James E Evans; Lawrence J Stern
Vaccinia peptides eluted from HLA-DR1 isolated from virus-infected cells are recognized by CD4+ T cells from a vaccinated donor.
Journal of proteome research 2008;7(7):2703-11.
2008: Sabrina S Vollers; Lawrence J Stern
Class II major histocompatibility complex tetramer staining: progress, problems, and prospects.
Immunology 2008;123(3):305-13.
2008: Sriram Chitta; Laura Santambrogio; Lawrence J Stern
GMCSF in the absence of other cytokines sustains human dendritic cell precursors with T cell regulatory activity and capacity to differentiate into functional dendritic cells.
Immunology letters 2008;116(1):41-54.
2008: Corrie A Painter; Anthony Cruz; Gustavo E López; Lawrence J Stern; Zarixia Zavala-Ruiz
Model for the peptide-free conformation of class II MHC proteins.
PloS one 2008;3(6):e2403.
2007: J Mauricio Calvo-Calle; Iwona Strug; Maria-Dorothea Nastke; Stephen Baker; Lawrence J Stern
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection.
PLoS pathogens 2007;3(10):1511-29.
2007: Lawrence J Stern
Characterizing MHC-associated peptides by mass spectrometry.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2667-8.
2007: Christian S Parry; Jack Gorski; Lawrence J Stern
Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.
Journal of molecular biology 2007;371(2):435-46.
2007: Shibani Mitra-Kaushik; John Cruz; Lawrence J Stern; Irene Bosch; Masanori Terajima
Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1303-12.
2007: Elke Duchardt; Alexander B Sigalov; Dikran Aivazian; Lawrence J Stern; Harald Schwalbe
Structure induction of the T-cell receptor zeta-chain upon lipid binding investigated by NMR spectroscopy.
Chembiochem : a European journal of chemical biology 2007;8(7):820-7.
2007: Prasanna Venkatraman; Tina T Nguyen; Matthieu Sainlos; Osman Bilsel; Sriram Chitta; Barbara Imperiali; Lawrence J Stern
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Nature chemical biology 2007;3(4):222-8.
2007: Souheil-Antoine Younes; Lydie Trautmann; Bader Yassine-Diab; Lena H Kalfayan; Anne-Elen Kernaleguen; Thomas O Cameron; Rachid Boulassel; Lawrence J Stern; Jean-Pierre Routy; Zvi Grossman; Alain R Dumont; Rafick-Pierre Sekaly
The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):788-97.
2006: Alexander B Sigalov; Dikran Aivazian; Vladimir Uversky; Lawrence J Stern
Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.
Biochemistry 2006;45(51):15731-9.
2006: Carlos Parra-López; J Mauricio Calvo-Calle; Thomas O Cameron; Luis Eduardo Vargas; Luz Mary Salazar; Manuel E Patarroyo; Elizabeth H Nardin; Lawrence J Stern
Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein.
The Journal of biological chemistry 2006;281(21):14907-17.
2006: Stephen L De Wall; Corrie Painter; Jennifer D Stone; Rajintha Bandaranayake; Don C Wiley; Timothy J Mitchison; Lawrence J Stern; Brian S DeDecker
Noble metals strip peptides from class II MHC proteins.
Nature chemical biology 2006;2(4):197-201.
2006: Philip J Norris; Jennifer D Stone; Nadezhda Anikeeva; John W Heitman; Ingrid C Wilson; Dale F Hirschkorn; Margaret J Clark; Howell F Moffett; Thomas O Cameron; Yuri Sykulev; Lawrence J Stern; Bruce D Walker
Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
Molecular immunology 2006;43(9):1349-57.
2006: Jennifer D Stone; Lawrence J Stern
CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1498-505.
2006: Lawrence J Stern; Ilaria Potolicchio; Laura Santambrogio
MHC class II compartment subtypes: structure and function.
Current opinion in immunology 2006;18(1):64-9.
2005: Gregory J Carven; Lawrence J Stern
Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping.
Biochemistry 2005;44(42):13625-37.
2005: Ilaria Potolicchio; Sriram Chitta; Xiaonan Xu; Dora Fonseca; Giovanna Crisi; Vaclav Horejsi; Jack L Strominger; Lawrence J Stern; Graça Raposo; Laura Santambrogio
Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):4935-47.
2005: Ilaria Potolicchio; Gregory J Carven; Xiaonan Xu; Christopher S Stipp; Richard J Riese; Lawrence J Stern; Laura Santambrogio
Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2237-43.
2005: Jennifer D Stone; Walter E Demkowicz; Lawrence J Stern
HLA-restricted epitope identification and detection of functional T cell responses by using MHC-peptide and costimulatory microarrays.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3744-9.
2005: Rick Baggio; Gregory J Carven; Anthony Chiulli; Michelle Palmer; Lawrence J Stern; Jaime E Arenas
Induced fit of an epitope peptide to a monoclonal antibody probed with a novel parallel surface plasmon resonance assay.
The Journal of biological chemistry 2005;280(6):4188-94.
2004: Zarixia Zavala-Ruiz; Iwona Strug; Matthew W Anderson; Jack Gorski; Lawrence J Stern
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins.
Chemistry & biology 2004;11(10):1395-402.
2004: Zarixia Zavala-Ruiz; Iwona Strug; Bruce D Walker; Philip J Norris; Lawrence J Stern
A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13279-84.
2004: Gregory J Carven; Sriram Chitta; Ivan Hilgert; Mia M Rushe; Rick F Baggio; Michelle Palmer; Jaime E Arenas; Jack L Strominger; Vaclav Horejsi; Laura Santambrogio; Lawrence J Stern
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.
The Journal of biological chemistry 2004;279(16):16561-70.
2004: efstratios stratikos; Don C Wiley; Lawrence J Stern
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1109-17.
2003: Zarixia Zavala-Ruiz; Eric Sundberg; Jennifer D Stone; Daniel B DeOliveira; Iat C Chan; Jennifer Svendsen; Roy A Mariuzza; Lawrence J Stern
Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.
The Journal of biological chemistry 2003;278(45):44904-12.
2002: Thomas O Cameron; George B Cohen; Sabina A Islam; Lawrence J Stern
Examination of the highly diverse CD4(+) T-cell repertoire directed against an influenza peptide: a step towards TCR proteomics.
Immunogenetics 2002;54(9):611-20.
2002: Qing Ge; Jennifer D Stone; M Todd Thompson; Jennifer Cochran; Mia M Rushe; Herman N Eisen; Jianzhu Chen; Lawrence J Stern
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13729-34.
2002: Thomas O Cameron; Philip J Norris; Alka Patel; Corinne Moulon; Eric S Rosenberg; Elizabeth D Mellins; Lucy R Wedderburn; Lawrence J Stern
Labeling antigen-specific CD4(+) T cells with class II MHC oligomers.
Journal of immunological methods 2002;268(1):51-69.
2002: Fabio Re; Svetlana L Belyanskaya; Richard J Riese; Barbara Cipriani; Falko R Fischer; Francesca Granucci; Paola Ricciardi-Castagnoli; Celia F Brosnan; Lawrence J Stern; Jack L Strominger; Laura Santambrogio
Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2264-73.
2002: Alexander B Sigalov; Lawrence J Stern
Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I.
Antioxidants & redox signaling 2002;4(3):553-7.
2002: Rossana Zaru; Thomas O Cameron; Lawrence J Stern; Sabina Müller; Salvatore Valitutti
Cutting edge: TCR engagement and triggering in the absence of large-scale molecular segregation at the T cell-APC contact site.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4287-91.
2001: Neer Asherie; Jayanti Pande; Ajay Pande; JA Zarutskie; J Lomakin; Aleksey Lomakin; Olutayo Ogun; Lawrence J Stern; Jonathan King; George B. Benedek
Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
Journal of molecular biology 2001;314(4):663-9.
2001: Alexander B Sigalov; Lawrence J Stern
Oxidation of methionine residues affects the structure and stability of apolipoprotein A-I in reconstituted high density lipoprotein particles.
Chemistry and physics of lipids 2001;113(1-2):133-46.
2001: Jennifer D Stone; Jennifer Cochran; Lawrence J Stern
T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model.
Biophysical journal 2001;81(5):2547-57.
2001: JA Zarutskie; R Busch; Zarixia Zavala-Ruiz; Mia M Rushe; E D Mellins; Lawrence J Stern
The kinetic basis of peptide exchange catalysis by HLA-DM.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12450-5.
2001: Jennifer Cochran; Thomas O Cameron; Jennifer D Stone; J B Lubetsky; Lawrence J Stern
Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation.
The Journal of biological chemistry 2001;276(30):28068-74.
2001: Laura Santambrogio; Svetlana L Belyanskaya; Falko R Fischer; Barbara Cipriani; Celia F Brosnan; Paola Ricciardi-Castagnoli; Lawrence J Stern; Jack L Strominger; Richard J Riese
Developmental plasticity of CNS microglia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6295-300.
2001: Jennifer Cochran; Dikran Aivazian; T O Cameron; Lawrence J Stern
Receptor clustering and transmembrane signaling in T cells.
Trends in biochemical sciences 2001;26(5):304-10.
2001: Thomas O Cameron; Jennifer Cochran; Bader Yassine-Diab; Rafick-Pierre Sékaly; Lawrence J Stern
Cutting edge: detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers is dependent on the T cell activation state.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):741-5.
2000: Dikran Aivazian; Lawrence J Stern
Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition.
Nature structural biology 2000;7(11):1023-6.
2000: D B De Oliveira; E Harfouch-Hammoud; H Otto; Nikolaos Papandreou; Lawrence J Stern; H Cohen; B O Boehm; J Bach; S Caillat-Zucman; T Walk; G Jung; Elias Eliopoulos; George K Papadopoulos; Peter van Endert
Structural analysis of two HLA-DR-presented autoantigenic epitopes: crucial role of peripheral but not central peptide residues for T-cell receptor recognition.
Molecular immunology 2000;37(14):813-25.
2000: Jennifer Cochran; Lawrence J Stern
A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions.
Chemistry & biology 2000;7(9):683-96.
2000: R V Joshi; JA Zarutskie; Lawrence J Stern
A three-step kinetic mechanism for peptide binding to MHC class II proteins.
Biochemistry 2000;39(13):3751-62.
2000: Jennifer Cochran; Thomas O Cameron; Lawrence J Stern
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers.
Immunity 2000;12(3):241-50.
2000: AK Sato; JA Zarutskie; Mia M Rushe; Aleksey Lomakin; SK Natarajan; Scheherazade Sadegh-Nasseri; George B. Benedek; Lawrence J Stern
Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.
The Journal of biological chemistry 2000;275(3):2165-73.
1999: Laura Santambrogio; A K Sato; Gregory J Carven; Svetlana L Belyanskaya; Jack L Strominger; Lawrence J Stern
Extracellular antigen processing and presentation by immature dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15056-61.
1999: Laura Santambrogio; A K Sato; Falko R Fischer; Martin E Dorf; Lawrence J Stern
Abundant empty class II MHC molecules on the surface of immature dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15050-5.
1999: A K Sato; Tiziana Sturniolo; Francesco Sinigaglia; Lawrence J Stern
Substitution of aspartic acid at beta57 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (alpha1*0201, beta1*0302) and (alpha1*0201, beta1*0303).
Human immunology 1999;60(12):1227-36.
1999: JA Zarutskie; AK Sato; Mia M Rushe; I C Chan; Aleksey Lomakin; George B. Benedek; Lawrence J Stern
A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding.
Biochemistry 1999;38(18):5878-87.
1999: SK Natarajan; Lawrence J Stern; Scheherazade Sadegh-Nasseri
Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3463-70.
1999: M Frayser; AK Sato; L Xu; Lawrence J Stern
Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro.
Protein expression and purification 1999;15(1):105-14.
1998: JL Schmitke; Lawrence J Stern; Alexander M Klibanov
Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12918-23.
1998: Alexander B Sigalov; Lawrence J Stern
Enzymatic repair of oxidative damage to human apolipoprotein A-I.
FEBS letters 1998;433(3):196-200.
1998: JL Schmitke; Lawrence J Stern; Alexander M Klibanov
Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents.
Biochemical and biophysical research communications 1998;248(2):273-7.
1997: JL Schmitke; Lawrence J Stern; Alexander M Klibanov
The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4250-5.
1993: Y N Zhang; Mostafa A El-Sayed; Lawrence J Stern; T Marti; Tatsushi Mogi; H Gobind Khorana
Effects of mutagenetic substitution of prolines on the rate of deprotonation and reprotonation of the Schiff base during the photocycle of bacteriorhodopsin.
Photochemistry and photobiology 1993;57(6):1027-31.
1991: G C Lin; Mostafa A El-Sayed; T Marti; Lawrence J Stern; Tatsushi Mogi; H Gobind Khorana
Effects of individual genetic substitutions of arginine residues on the deprotonation and reprotonation kinetics of the Schiff base during the bacteriorhodopsin photocycle.
Biophysical journal 1991;60(1):172-8.
1990: Kenneth Rothschild; Y W He; Tatsushi Mogi; T Marti; Lawrence J Stern; H Gobind Khorana
Vibrational spectroscopy of bacteriorhodopsin mutants: evidence for the interaction of proline-186 with the retinylidene chromophore.
Biochemistry 1990;29(25):5954-60.
1990: D J Jang; Mostafa A El-Sayed; Lawrence J Stern; Tatsushi Mogi; H Gobind Khorana
Effect of genetic modification of tyrosine-185 on the proton pump and the blue-to-purple transition in bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4103-7.
1990: J J Du; Mostafa A El-Sayed; Lawrence J Stern; Tatsushi Mogi; H Gobind Khorana
Sensitivity of the retinal circular dichroism of bacteriorhodopsin to the mutagenetic single substitution of amino acids: tyrosine.
FEBS letters 1990;262(2):155-8.
1990: Harald Otto; T Marti; M Holz; Tatsushi Mogi; Lawrence J Stern; F Engel; H Gobind Khorana; Maarten P Heyn
Substitution of amino acids Asp-85, Asp-212, and Arg-82 in bacteriorhodopsin affects the proton release phase of the pump and the pK of the Schiff base.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1018-22.
1989: Lawrence J Stern; P L Ahl; T Marti; Tatsushi Mogi; M Duñach; S Berkowitz; Kenneth Rothschild; H Gobind Khorana
Substitution of membrane-embedded aspartic acids in bacteriorhodopsin causes specific changes in different steps of the photochemical cycle.
Biochemistry 1989;28(26):10035-42.
1989: P L Ahl; Lawrence J Stern; Tatsushi Mogi; H Gobind Khorana; Kenneth Rothschild
Substitution of amino acids in helix F of bacteriorhodopsin: effects on the photochemical cycle.
Biochemistry 1989;28(26):10028-34.
1989: Lawrence J Stern; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. X. Individual substitutions of arginine residues by glutamine affect chromophore formation, photocycle, and proton translocation.
The Journal of biological chemistry 1989;264(24):14202-8.
1989: Tatsushi Mogi; Lawrence J Stern; B H Chao; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. VIII. Substitutions of the membrane-embedded prolines 50, 91, and 186: the effects are determined by the substituting amino acids.
The Journal of biological chemistry 1989;264(24):14192-6.
1989: Kenneth Rothschild; D Gray; Tatsushi Mogi; T Marti; Mark S Braiman; Lawrence J Stern; H Gobind Khorana
Vibrational spectroscopy of bacteriorhodopsin mutants: chromophore isomerization perturbs tryptophan-86.
Biochemistry 1989;28(17):7052-9.
1989: Kenneth Rothschild; Mark S Braiman; Tatsushi Mogi; Lawrence J Stern; H Gobind Khorana
Conserved amino acids in F-helix of bacteriorhodopsin form part of a retinal binding pocket.
FEBS letters 1989;250(2):448-52.
1988: Mark S Braiman; Tatsushi Mogi; T Marti; Lawrence J Stern; H Gobind Khorana; Kenneth Rothschild
Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212.
Biochemistry 1988;27(23):8516-20.
1988: P L Ahl; Lawrence J Stern; D Düring; Tatsushi Mogi; H Gobind Khorana; Kenneth Rothschild
Effects of amino acid substitutions in the F helix of bacteriorhodopsin. Low temperature ultraviolet/visible difference spectroscopy.
The Journal of biological chemistry 1988;263(27):13594-601.
1988: Tatsushi Mogi; Lawrence J Stern; T Marti; B H Chao; H Gobind Khorana
Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4148-52.
1988: Mark S Braiman; Tatsushi Mogi; Lawrence J Stern; N R Hackett; B H Chao; H Gobind Khorana; Kenneth Rothschild
Vibrational spectroscopy of bacteriorhodopsin mutants: I. Tyrosine-185 protonates and deprotonates during the photocycle.
Proteins 1988;3(4):219-29.
1987: Tatsushi Mogi; Lawrence J Stern; N R Hackett; H Gobind Khorana
Bacteriorhodopsin mutants containing single tyrosine to phenylalanine substitutions are all active in proton translocation.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5595-9.
1987: N R Hackett; Lawrence J Stern; B H Chao; K A Kronis; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. V. Effects of amino acid substitutions in the putative helix F.
The Journal of biological chemistry 1987;262(19):9277-84.
1987: Mark S Braiman; Lawrence J Stern; B H Chao; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. IV. Purification and renaturation of bacterio-opsin polypeptide expressed in Escherichia coli.
The Journal of biological chemistry 1987;262(19):9271-6.