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Hiroyasu Nakano

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

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Publications

TOP 3
Xuehua Piao; Günther Schütz; Yasuo Uchiyama; Nico van Rooijen; Hideo Yagita; Hanno Ehlken; Mutsuko Hara; You-Wen He; Masato Koike; Sachiko Komazawa-Sakon; Hidetake Kurihara; Takashi Nishina; Masaki Ohmuraya; Ko Okumura; Jiang-Hu Piao; Hiroyasu Nakano
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Takashi Nishina; Ko Okumura; Jiang-Hu Piao; Xuehua Piao; Tracy Putoczki; Emiko Sano; Kouhei Tsumoto; Takashi Ueno; Hiroko Ushio; Shunhei Yamashina; Saeko Yanaka; Dong-Mei Zheng; Takahiro Doi; Matthias Ernst; Junji Ezaki; Yuko Kojima; Sachiko Komazawa-Sakon; Hiroyasu Nakano
Interleukin-11 links oxidative stress and compensatory proliferation.
Emmanuel Charbonney; András Masszi; Hiroyasu Nakano; Pam Speight; Andras Kapus
β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition.

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All Publications

2012: Xuehua Piao; Günther Schütz; Yasuo Uchiyama; Nico van Rooijen; Hideo Yagita; Hanno Ehlken; Mutsuko Hara; You-Wen He; Masato Koike; Sachiko Komazawa-Sakon; Hidetake Kurihara; Takashi Nishina; Masaki Ohmuraya; Ko Okumura; Jiang-Hu Piao; Hiroyasu Nakano
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Science signaling 2012;5(255):ra93.
2012: Takashi Nishina; Ko Okumura; Jiang-Hu Piao; Xuehua Piao; Tracy Putoczki; Emiko Sano; Kouhei Tsumoto; Takashi Ueno; Hiroko Ushio; Shunhei Yamashina; Saeko Yanaka; Dong-Mei Zheng; Takahiro Doi; Matthias Ernst; Junji Ezaki; Yuko Kojima; Sachiko Komazawa-Sakon; Hiroyasu Nakano
Interleukin-11 links oxidative stress and compensatory proliferation.
Science signaling 2012;5(207):ra5.
2011: Emmanuel Charbonney; András Masszi; Hiroyasu Nakano; Pam Speight; Andras Kapus
β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition.
Molecular biology of the cell 2011;22(23):4472-85.
2011: Hiroyasu Nakano; Hiroko Ushio
An unexpected role for autophagy in degranulation of mast cells.
Autophagy 2011;7(6):657-9.
2011: Hiroko Ushio; Takashi Ueno; Yuko Kojima; Masaaki Komatsu; Satoshi Tanaka; Akitsugu Yamamoto; Yoshinobu Ichimura; Junji Ezaki; Keigo Nishida; Sachiko Komazawa-Sakon; François Niyonsaba; Tetsuro Ishii; Toru Yanagawa; Eiki Kominami; Hideoki Ogawa; Ko Okumura; Hiroyasu Nakano
Crucial role for autophagy in degranulation of mast cells.
The Journal of allergy and clinical immunology 2011;127(5):1267-76.e6.
2008: Taisuke Sawada; Chiharu Nishiyama; Takuma Kishi; Tomonari Sasazuki; Sachiko Komazawa-Sakon; Xin Xue; Jiang-Hu Piao; Hideko Ogata; Jun-ichi Nakayama; Tomohiko Taki; Yasuhide Hayashi; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.
The Journal of biological chemistry 2008;283(39):26820-8.
2008: Akihito Nakajima; Hidetake Kurihara; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Mitochondrial Extrusion through the cytoplasmic vacuoles during cell death.
The Journal of biological chemistry 2008;283(35):24128-35.
2007: Jiang-Hu Piao; Hisahiro Yoshida; Wen-Chen Yeh; Takahiro Doi; Xin Xue; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2272-7.
2006: Akihito Nakajima; Sachiko Komazawa-Sakon; Mutsuhiro Takekawa; Tomonari Sasazuki; Wen-Chen Yeh; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.
The EMBO journal 2006;25(23):5549-59.
2006: Keiko Maeda; Chiharu Nishiyama; Tomoko Tokura; Hiroyasu Nakano; Shunsuke Kanada; Makoto Nishiyama; Ko Okumura; Hideoki Ogawa
FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice.
Blood 2006;108(1):262-9.
2006: Hiroyasu Nakano; Akihito Nakajima; Sachiko Sakon-Komazawa; Jiang-Hu Piao; Xin Xue; Ko Okumura
Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.
Cell death and differentiation 2006;13(5):730-7.
2005: Xin Xue; Jiang-Hu Piao; Akihito Nakajima; Sachiko Sakon-Komazawa; Yuko Kojima; Kazutoshi Mori; Hideo Yagita; Ko Okumura; Heather Harding; Hiroyasu Nakano
Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha.
The Journal of biological chemistry 2005;280(40):33917-25.
2005: Hiroyasu Nakano
A revival of old players.
EMBO reports 2005;6(2):126-7.
2005: Hiroyasu Nakano
[Signaling crosstalk between NF-kappaB and JNK].
Seikagaku. The Journal of Japanese Biochemical Society 2005;77(1):29-32.
2004: Hiroyasu Nakano
Signaling crosstalk between NF-kappaB and JNK.
Trends in immunology 2004;25(8):402-5.
2004: Tomonari Sasazuki; Tatsuma Okazaki; Kurisu Tada; Sachiko Sakon-Komazawa; Mitsuo Katano; Masao Tanaka; Hideo Yagita; Ko Okumura; Naoko Tominaga; Yoshihide Hayashizaki; Yasushi Okazaki; Hiroyasu Nakano
Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.
Molecular immunology 2004;41(5):547-51.
2003: Sachiko Sakon; Xin Xue; Mutsuhiro Takekawa; Tomonari Sasazuki; Tatsuma Okazaki; Yuko Kojima; Jian-Hu Piao; Hideo Yagita; Ko Okumura; Takahiro Doi; Hiroyasu Nakano
NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.
The EMBO journal 2003;22(15):3898-909.
2003: Tatsuma Okazaki; Sachiko Sakon; Tomonari Sasazuki; Hiroaki Sakurai; Takahiro Doi; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses.
Biochemical and biophysical research communications 2003;300(4):807-12.
2002: Norihiro Harada; Masafumi Nakayama; Hiroyasu Nakano; Yoshinosuke Fukuchi; Hideo Yagita; Ko Okumura
Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.
Biochemical and biophysical research communications 2002;299(3):488-93.
2002: Tomonari Sasazuki; Taisuke Sawada; Sachiko Sakon; Toshio Kitamura; Takuma Kishi; Tatsuma Okazaki; Mitsuo Katano; Masao Tanaka; Mamoru Watanabe; Hideo Yagita; Ko Okumura; Hiroyasu Nakano
Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
The Journal of biological chemistry 2002;277(32):28853-60.
2002: Masafumi Nakayama; Kazumi Ishidoh; Nobuhiko Kayagaki; Yuko Kojima; Noriko Yamaguchi; Hiroyasu Nakano; Eiki Kominami; Ko Okumura; Hideo Yagita
Multiple pathways of TWEAK-induced cell death.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):734-43.
2001: K Tada; Tatsuma Okazaki; Sachiko Sakon; T Kobarai; K Kurosawa; S Yamaoka; H Hashimoto; T W Mak; Hideo Yagita; Ko Okumura; Wen-Chen Yeh; Hiroyasu Nakano
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.
The Journal of biological chemistry 2001;276(39):36530-4.
2001: T Okazaki; Atsuhito Nakao; Hiroyasu Nakano; F Takahashi; Kyoko Takahashi; O Shimozato; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura
Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1977-81.
1999: Hiroyasu Nakano; Sachiko Sakon; H Koseki; T Takemori; K Tada; M Matsumoto; E Munechika; T Sakai; T Shirasawa; Hisaya Akiba; Tetsuji Kobata; SM Santee; Carl Ware; P D Rennert; M Taniguchi; Hideo Yagita; Ko Okumura
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9803-8.
1999: Hisaya Akiba; H Oshima; Kazuyoshi Takeda; M Atsuta; Hiroyasu Nakano; Atsuo Nakajima; C Nohara; Hideo Yagita; Ko Okumura
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7058-66.
1998: Hisaya Akiba; Hiroyasu Nakano; S Nishinaka; M Shindo; Tetsuji Kobata; M Atsuta; Chikao Morimoto; Carl Ware; NL Malinin; David Wallach; Hideo Yagita; Ko Okumura
CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase.
The Journal of biological chemistry 1998;273(21):13353-8.
1998: Hiroyasu Nakano; M Shindo; Sachiko Sakon; S Nishinaka; M Mihara; Hideo Yagita; Ko Okumura
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3537-42.
1998: M Shindo; Hiroyasu Nakano; Hidehito Kuroyanagi; Takuji Shirasawa; M Mihara; D J Gilbert; N A Jenkins; N G Copeland; Hideo Yagita; Ko Okumura
cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.
Biochemical and biophysical research communications 1998;244(1):285-92.
1998: M Shindo; Hiroyasu Nakano; Sachiko Sakon; Hideo Yagita; M Mihara; Ko Okumura
Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.
Cytogenetics and cell genetics 1998;82(1-2):32-3.
1997: Hiroyasu Nakano; M Shindo; K Yamada; M C Yoshida; SM Santee; Carl Ware; N A Jenkins; D J Gilbert; Hideo Yagita; N C Copeland; Ko Okumura
Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.
Genomics 1997;42(1):26-32.
1996: Hiroyasu Nakano; H Oshima; W Chung; L Williams-Abbott; Carl Ware; Hideo Yagita; K Okumura
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.
The Journal of biological chemistry 1996;271(25):14661-4.