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Patrick Durez

Research Profile

Disorders

Rheumatoid Arthritis

Chemicals & Drugs

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Publications

TOP 3
Mark C Genovese; Sophie Hugot; Takashi Ikawa; Herbert Kellner; Sang-Heon Lee; Vadim Mazurov; Jacob A Aelion; Christine E Codding; Eva Dokoupilova; Patrick Durez; Hanno B Richards; Jerzy Supronik; Shephard Mpofu
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study.
René Westhovens; piet wigerinck; Johan Beetens; Filip De Keyser; Florence Namour; Evgeny L Nasonov; Dmytro Rekalov; Annegret Van der Aa; Frédéric Vanhoutte; Patrick Durez
Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial.
Josef S Smolen; Annette Szumski; Patrick Durez; Stephen Hall; Constance Hammond; Elena Ilivanova; Fedra Irazoque-Palazuelos; Andrew S Koenig; Pedro Miranda; Peter Nash; Min-Chan Park; Karel Pavelka; Ronald Pedersen; Bonnie Vlahos
Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (PRESERVE): a randomised controlled trial.

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All Publications

2013: Mark C Genovese; Sophie Hugot; Takashi Ikawa; Herbert Kellner; Sang-Heon Lee; Vadim Mazurov; Jacob A Aelion; Christine E Codding; Eva Dokoupilova; Patrick Durez; Hanno B Richards; Jerzy Supronik; Shephard Mpofu
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study.
Annals of the rheumatic diseases 2013;72(6):863-9.
2013: René Westhovens; piet wigerinck; Johan Beetens; Filip De Keyser; Florence Namour; Evgeny L Nasonov; Dmytro Rekalov; Annegret Van der Aa; Frédéric Vanhoutte; Patrick Durez
Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial.
Annals of the rheumatic diseases 2013;72(5):741-4.
2013: Josef S Smolen; Annette Szumski; Patrick Durez; Stephen Hall; Constance Hammond; Elena Ilivanova; Fedra Irazoque-Palazuelos; Andrew S Koenig; Pedro Miranda; Peter Nash; Min-Chan Park; Karel Pavelka; Ronald Pedersen; Bonnie Vlahos
Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (PRESERVE): a randomised controlled trial.
Lancet 2013;381(9870):918-29.
2011: Boulos Haraoui; Maria José Jannaut Peña; Joachim Kalden; Tore K Kvien; Ieda Laurindo; E Martin-Mola; Carlomaurizio Montecucco; Karel Pavelka; Gyula Poor; Pedro Santos Moreno; Josef S Smolen; Ewa Stanislawska-Biernat; Tsutomu Takeuchi; Désirée van der Heijde; Daniel Aletaha; Ferdinand C Breedveld; GR Burmester; Mario H Cardiel; Catalin Codreanu; José Pereira Da Silva; Maarten de Wit; Maxime Dougados; Patrick Durez; Paul Emery; João Eurico Fonseca; Allan Gibofsky; Juan Gomez-Reino; Winfried Graninger; Vedat Hamuryudan
Treating Rheumatoid Arthritis to Target: multinational recommendations assessment questionnaire.
Annals of the rheumatic diseases 2011;70(11):1999-2002.
2011: V Badot; Patrick Durez; Frédéric A Houssiau; A Nzeusseu-Toukap; Benoît J Van den Eynde; Bernard R Lauwerys
Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines.
Journal of cellular and molecular medicine 2011;15(11):2335-42.
2011: Mark C Genovese; M Keiserman; C Legerton; G Leon; E Mysler; P Nash; E Nasonov; R Pappu; W Porawska; J A Simon-Campos; J Teng; R Valente; R Aranda; J Box; A Covarrubias; I Delaet; Patrick Durez; R Alten
Subcutaneous abatacept versus intravenous abatacept: a phase IIIb noninferiority study in patients with an inadequate response to methotrexate.
Arthritis and rheumatism 2011;63(10):2854-64.
2011: Josef S Smolen; Eric C Abadie; Bernard P Avouac; Thomas Bardin; Maarten Boers; Ferdinand C Breedveld; Patrick Durez; Paul Emery; Dominique J Ethgen; Bruno Flamion; Niti Goel; Andrea Laslop; Pierre Miossec; Jean-Yves Reginster; Susanne Reiter
Updating the 2003 European regulatory requirements for registering disease-modifying drugs to be used in the treatment of rheumatoid arthritis.
Rheumatology (Oxford, England) 2011;50(10):1732-6.
2011: Frank van de Veerdonk; Bernard Lauwerys; Renoud J Marijnissen; Kim Timmermans; Franco E Di Padova; Marije I Koenders; Ilse Gutierrez-Roelens; Patrick Durez; Mihai G Netea; Jos W M van der Meer; Wim B van den Berg; Leo A B Joosten
The anti-CD20 antibody rituximab reduces the Th17 cell response.
Arthritis and rheumatism 2011;63(6):1507-16.
2011: Glen Hazlewood; Daniel Aletaha; Loreto Carmona; Robert B M Landewé; Désirée M van der Heijde; Johannes W J Bijlsma; Vivian P Bykerk; Helena Canhão; Anca I Catrina; Patrick Durez; Christopher J Edwards; Burkhard F Leeb; Maria D Mjaavatten; Pindaro Martinez-Osuna; Carlomaurizio Montecucco; Mikkel Ostergaard; Natali Serra-Bonett; Ricardo M Xavier; Jane Zochling; Pedro Machado; Kristof Thevissen; Ward Vercoutere; Claire Bombardier
Algorithm for identification of undifferentiated peripheral inflammatory arthritis: a multinational collaboration through the 3e initiative.
The Journal of rheumatology. Supplement 2011;87():54-8.
2011: Josef S Smolen; Maarten Boers; Eric C Abadie; Ferdinand C Breedveld; Paul Emery; Thomas Bardin; Niti Goel; Dominique J Ethgen; Bernard P Avouac; Willard H Dere; Patrick Durez; Marco Matucci-Cerinic; Bruno Flamion; Andrea Laslop; Frits J Lekkerkerker; Pierre Miossec; Bruce H Mitlak; Sif Ormarsdóttir; Laurence Paolozzi; Ravi Rao; Susan Reiter; Yannis Tsouderos; Jean-Yves Reginster
Recommendations for an update of 2003 European regulatory requirements for registration of drugs to be used in the treatment of RA.
Current medical research and opinion 2011;27(2):315-25.
2011: RIEKE ALTEN; Udayasankar Arulmani; Andre Beaulieu; Patrick Durez; Xavier Gitton; Juan Gomez-Reino; Gerhard Krammer; Ralph Preiss; Anthony Sebba; Albert Widmer; Herbert Kellner
Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study.
BMC musculoskeletal disorders 2011;12():153.
2011: Charles Sèbiyo Batcho; Patrick Durez; Jean-Louis Thonnard
Responsiveness of the ABILHAND questionnaire in measuring changes in rheumatoid arthritis patients.
Arthritis care & research 2011;63(1):135-41.
2010: Wolfgang Hueber; Dhavalkumar D Patel; Thaddeus Dryja; Andrew M Wright; Irina Koroleva; Gerard Bruin; Christian Antoni; Zoe Draelos; Michael H Gold; Patrick Durez; Paul P Tak; Juan J Gomez-Reino; C Stephen Foster; Rosa Y Kim; C Michael Samson; Naomi S Falk; David S Chu; David Callanan; Quan Dong Nguyen; Kristine Rose; Asifa Haider; Franco E Di Padova
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.
Science translational medicine 2010;2(52):52ra72.
2010: Karim Zouaoui Boudjeltia; Patrick Durez; Didier Oberweis; Michel Guillaume; Claude Remacle; Philippe Cauchie; Michel Vanhaeverbeek; Dany Brohée; Jean Ducobu; Catherine Gregoir
Effects of raloxifene treatment on the phenotype of blood monocytes.
Canadian journal of physiology and pharmacology 2010;88(5):601-5.
2010: Bert Vander Cruyssen; Patrick Durez; Rene Westhovens; Marie-Joelle Kaiser; Ilse Hoffman; Filip De Keyser
The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies.
Arthritis research & therapy 2010;12(5):R169.
2010: Bert Vander Cruyssen; Patrick Durez; René Westhovens; Filip De Keyser
Seven-year follow-up of infliximab therapy in rheumatoid arthritis patients with severe long-standing refractory disease: attrition rate and evolution of disease activity.
Arthritis research & therapy 2010;12(3):R77.
2009: Paul Emery; Roy M Fleischmann; Larry W Moreland; Elizabeth C Hsia; Ingrid Strusberg; Patrick Durez; Peter Nash; Eric Jason B Amante; Melvin Churchill; Won Park; Bernardo Antonio Pons-Estel; Mittie K Doyle; Sudha Visvanathan; Weichun Xu; Mahboob U Rahman
Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis.
Arthritis and rheumatism 2009;60(8):2272-83.
2009: Valérie Badot; Christine Galant; Adrien Nzeusseu Toukap; Ivan Theate; Anne-Lise Maudoux; Benoît J Van den Eynde; Patrick Durez; Frédéric A Houssiau; Bernard R Lauwerys
Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis.
Arthritis research & therapy 2009;11(2):R57.
2008: Paul Emery; Ferdinand C Breedveld; Stephen Hall; Patrick Durez; David J Chang; Deborah Robertson; Amitabh Singh; Ronald D Pedersen; Andrew S Koenig; Bruce Freundlich
Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial.
Lancet 2008;372(9636):375-82.
2008: Jonathan Kay; Eric L Matteson; Bhaskar Dasgupta; Peter Nash; Patrick Durez; Stephen Hall; Elizabeth C Hsia; John Han; Carrie Wagner; Zhenhua Xu; Sudha Visvanathan; Mahboob U Rahman
Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: a randomized, double-blind, placebo-controlled, dose-ranging study.
Arthritis and rheumatism 2008;58(4):964-75.
2007: Patrick Durez; Jacques Malghem; Adrien Nzeusseu Toukap; Geneviève Depresseux; Bernard R Lauwerys; René Westhovens; Frank P Luyten; Luc Corluy; Frédéric A Houssiau; Patrick Verschueren
Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone.
Arthritis and rheumatism 2007;56(12):3919-27.
2007: Thomas Kesteman; Jean-Cyr Yombi; Jacques Gigi; Patrick Durez
Listeria infections associated with infliximab: case reports.
Clinical rheumatology 2007;26(12):2173-5.
2007: Patrick Durez; Virginie Fraselle; Frédéric A Houssiau; Jean-Louis Thonnard; Henri Nielens; Massimo Penta
Validation of the ABILHAND questionnaire as a measure of manual ability in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2007;66(8):1098-105.
2007: Federico Díaz-González; RIEKE ALTEN; William G Bensen; Jacques P Brown; John T Sibley; Maxime Dougados; Stefano Bombardieri; Patrick Durez; Pablo Ortiz; Gonzalo de-Miquel; Alexander Staab; Ralf Sigmund; Laurence Salin; Caroline Leledy; Stephen H Polmar
Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 2007;66(5):628-32.
2006: Michael H Weisman; Patrick Durez; David Hallegua; Richard Aranda; Jean-Claude Becker; Isaac Nuamah; George Vratsanos; Ye Zhou; Larry W Moreland
Reduction of inflammatory biomarker response by abatacept in treatment of rheumatoid arthritis.
The Journal of rheumatology 2006;33(11):2162-6.
2006: René Westhovens; Frédéric A Houssiau; Johan Joly; Daniel E Everitt; Yaowei Zhu; Deborah Sisco; Bart Van Hartingsveldt; Mary Ann Mascelli; Martin A Graham; Patrick Durez; Esther Bouman-Thio
A phase I study assessing the safety, clinical response, and pharmacokinetics of an experimental infliximab formulation for subcutaneous or intramuscular administration in patients with rheumatoid arthritis.
The Journal of rheumatology 2006;33(5):847-53.
2006: Bert Vander Cruyssen; Patrick Durez; René Westhovens; Nathan Vastesaeger; Anja Geldhof; Filip De Keyser
Response to the commentary 'Pooled indices to measure rheumatoid arthritis activity: a good reflection of the physician's mind'.
Arthritis research & therapy 2006;8(6):406.
2006: Bert Vander Cruyssen; Stijn Van Looy; Bart Wyns; René Westhovens; Patrick Durez; Filip Van den Bosch; Herman Mielants; Luc De Clerck; Ann Peretz; Michel Malaise; Leon Verbruggen; Nathan Vastesaeger; Anja Geldhof; Luc Boullart; Filip De Keyser
Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity.
Arthritis research & therapy 2006;8(4):R112.
2005: René Westhovens; Annelies Boonen; Leon Verbruggen; Patrick Durez; L De Clerck; Michel Malaise; Herman Mielants
Healthcare consumption and direct costs of rheumatoid arthritis in Belgium.
Clinical rheumatology 2005;24(6):615-9.
2005: Joel M Kremer; Maxime Dougados; Paul Emery; Patrick Durez; Jean Sibilia; William Shergy; Serge D Steinfeld; Elizabeth Tindall; Jean-Claude Becker; Tracy Li; Isaac Nuamah; Richard Aranda; Larry W Moreland
Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial.
Arthritis and rheumatism 2005;52(8):2263-71.
2005: Patrick Durez; F Van den Bosch; Luc Corluy; Eric M Veys; L De Clerck; A Peretz; Michel Malaise; Jean-Pierre Devogelaer; Nathan Vastesaeger; Anja Geldhof; René Westhovens
A dose adjustment in patients with rheumatoid arthritis not optimally responding to a standard dose of infliximab of 3 mg/kg every 8 weeks can be effective: a Belgian prospective study.
Rheumatology (Oxford, England) 2005;44(4):465-8.
2005: Bert Vander Cruyssen; Stijn Van Looy; Bart Wyns; René Westhovens; Patrick Durez; Filip Van den Bosch; Eric M Veys; Herman Mielants; Luc De Clerck; Anne Peretz; Michel Malaise; Leon Verbruggen; Nathan Vastesaeger; Anja Geldhof; Luc Boullart; Filip De Keyser
DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment.
Arthritis research & therapy 2005;7(5):R1063-71.
2004: Patrick Durez; Adrien Nzeusseu Toukap; Bernard R Lauwerys; DH Manicourt; Patrick Verschueren; René Westhovens; Jean-Pierre Devogelaer; Frédéric A Houssiau
A randomised comparative study of the short term clinical and biological effects of intravenous pulse methylprednisolone and infliximab in patients with active rheumatoid arthritis despite methotrexate treatment.
Annals of the rheumatic diseases 2004;63(9):1069-74.
2004: Dominique Baeten; Filip De Keyser; Eric M Veys; Y Theate; Frédéric A Houssiau; Patrick Durez
Tumour necrosis factor alpha independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules.
Annals of the rheumatic diseases 2004;63(5):489-93.
2004: John A Snowden; Jakob Passweg; John J Moore; Sam Milliken; Paul Cannell; Jacob M van Laar; Robert J Verburg; Jeff Szer; Kerry Taylor; David Joske; Simon Rule; Sarah J Bingham; Paul Emery; Richard K Burt; Raymond Lowenthal; Patrick Durez; Robert J McKendry; Steven Z Pavletic; Ildefonso Espigado; Esa Jantunen; Ashwin Kashyap; Marco Rabusin; Peter Brooks; Christopher N Bredeson; Alan Tyndall
Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR.
The Journal of rheumatology 2004;31(3):482-8.
1999: Alan Tyndall; AB Fassas; Jakob Passweg; C Ruiz de Elvira; M Attal; Peter Brooks; C Black; Patrick Durez; J Finke; Stephen Forman; Loïc Fouillard; D Furst; J Holmes; David Joske; Jean-Pierre Jouet; Ina Kötter; F Locatelli; H Prentice; Alberto M Marmont; Peter McSweeney; Maurizio Musso; H H Peter; John A Snowden; K Sullivan; Alois Gratwohl
Autologous haematopoietic stem cell transplants for autoimmune disease--feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease.
Bone marrow transplantation 1999;24(7):729-34.
1999: Patrick Durez; Thierry Appelboom; C Pira; P Stordeur; Bernard Vray; M Goldman
Antiinflammatory properties of mycophenolate mofetil in murine endotoxemia: inhibition of TNF-alpha and upregulation of IL-10 release.
International journal of immunopharmacology 1999;21(9):581-7.
1998: Patrick Durez; Thierry Appelboom; Bernard Vray; C Pira; Michel Goldman
Methotrexate inhibits LPS-induced tumor necrosis factor production in vivo.
European cytokine network 1998;9(4):669-72.
1998: Patrick Durez; L Tourné; W Feremans; F Mascart-Lemone; Michel Heenen; Thierry Appelboom
Dramatic response to intravenous high dose gamma-globulin in refractory vasculitis of the skin associated with Sjögren's syndrome.
The Journal of rheumatology 1998;25(5):1032-3.
1997: Serge D Steinfeld; Patrick Durez; Jean-Philippe Hauzeur; S Motte; Thierry Appelboom
Articular aspergillosis: two case reports and review of the literature.
British journal of rheumatology 1997;36(12):1331-4.
1997: T Simonart; Patrick Durez; J Margaux; JP Van Geertruyden; DP Goldschmidt; D Parent
Cutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: a possible manifestation of methotrexate hypersensitivity.
Clinical rheumatology 1997;16(6):623-5.
1997: L Tourne; Patrick Durez; Jean-Paul Van Vooren; Claire M Farber; Corinne Liesnard; Michel Heenen; D Parent
Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine.
Journal of the American Academy of Dermatology 1997;37(3 Pt 1):501-2.
1996: N Sadeghi; E Fumière; Patrick Durez; Celso Matos; Julien Struyven
Primary biliary cirrhosis and bone changes.
Journal belge de radiologie 1996;79(4):160-1.
1995: Patrick Stordeur; Liliane Schandené; Patrick Durez; C Gérard; Michel Goldman; Thierry Velu
Spontaneous and cycloheximide-induced interleukin-10 mRNA expression in human mononuclear cells.
Molecular immunology 1995;32(4):233-9.
1994: Thierry Appelboom; Patrick Durez
Effect of milk product deprivation on spondyloarthropathy.
Annals of the rheumatic diseases 1994;53(7):481-2.
1994: Vincent Donckier; Daniel Abramowicz; Patrick Durez; C Gérard; Thierry Velu; Michel Goldman
Defective production of IFN-gamma in neonatally tolerant mice: involvement of IL-10.
Transplantation proceedings 1994;26(1):237.
1993: Thierry Velu; Patrick Durez; M Van Mechelen; C Gérard; Daniel Abramowicz; Muriel Moser; Oberdan Leo; Michel Goldman
In vivo induction of IL-10 by anti-CD3 monoclonal antibody in mice.
Transplantation proceedings 1993;25(1 Pt 1):568-9.
1993: Daniel Abramowicz; Patrick Durez; C Gerard; Vincent Donckier; Z Amraoui; Thierry Velu; Michel Goldman
Neonatal induction of transplantation tolerance in mice is associated with in vivo expression of IL-4 and -10 mRNAs.
Transplantation proceedings 1993;25(1 Pt 1):312-3.
1993: Patrick Durez; Daniel Abramowicz; C Gérard; M Van Mechelen; Z Amraoui; C Dubois; Oberdan Leo; Thierry Velu; Michel Goldman
In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A.
The Journal of experimental medicine 1993;177(2):551-5.
1990: D Feron; Michel Goldman; Frédérique Jacobs; Corinne Liesnard; M Depierreux; C Tilmant; Patrick Durez; E Serruys; J Wybran
Bone marrow aspiration as a diagnostic tool for acute toxoplasmosis in a kidney transplant recipient.
Transplantation 1990;50(6):1054-5.