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Klaus Okkenhaug

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TOP 3
Klaus Okkenhaug
Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity.
Klaus Okkenhaug
Signaling by the phosphoinositide 3-kinase family in immune cells.
David K Finlay; Jens L Hukelmann; Klaus Okkenhaug; Andrey A Panteleyev; Julia Rolf; Ella Rosenzweig; Linda V Sinclair; Carmen Feijoo-Carnero; Doreen A Cantrell
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.

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All Publications

2013: Klaus Okkenhaug
Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity.
Annals of the New York Academy of Sciences 2013;1280():24-6.
2013: Klaus Okkenhaug
Signaling by the phosphoinositide 3-kinase family in immune cells.
Annual review of immunology 2013;31():675-704.
2012: David K Finlay; Jens L Hukelmann; Klaus Okkenhaug; Andrey A Panteleyev; Julia Rolf; Ella Rosenzweig; Linda V Sinclair; Carmen Feijoo-Carnero; Doreen A Cantrell
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
The Journal of experimental medicine 2012;209(13):2441-53.
2012: Dalya R Soond; Martin Turner; Fabien Garçon; Oliver A Garden; Daniel Patton; Julia Rolf; Cheryl Scudamore; Klaus Okkenhaug
Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5935-43.
2012: Edward Banham-Hall; Menna R Clatworthy; Klaus Okkenhaug
The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases.
The open rheumatology journal 2012;6():245-58.
2012: Dalya R Soond; Oliver A Garden; Daniel Patton; Elizabeth C M Slack; Klaus Okkenhaug
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Frontiers in immunology 2012;3():244.
2012: Huijun Ying; Hongmei Fu; Ann M McCormack; Klaus Okkenhaug; Marlene L Rose; Padmini Sarathchandra; Federica M Marelli-Berg
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
PloS one 2012;7(3):e32892.
2011: Andrew N Macintyre; David Finlay; Gavin Preston; Linda V Sinclair; Caryll M Waugh; Peter Tamas; Carmen Feijoo; Klaus Okkenhaug; Doreen A Cantrell
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Immunity 2011;34(2):224-36.
2011: Suhasini Kulkarni; Cassian Sitaru; Zoltan Jakus; Karen E Anderson; George Damoulakis; Keith Davidson; Misa Hirose; Jatinder Juss; David Oxley; Tamara A M Chessa; Faruk Ramadani; Herve Guillou; Anne Segonds-Pichon; Anja Fritsch; Gavin E Jarvis; Klaus Okkenhaug; Ralf Ludwig; Detlef Zillikens; Attila Mócsai; Bart Vanhaesebroeck; Len R Stephens; Phillip T Hawkins
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
Science signaling 2011;4(168):ra23.
2011: Daniel T Patton; Marcus D Wilson; Wendy C Rowan; Dalya R Soond; Klaus Okkenhaug
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
PloS one 2011;6(3):e17359.
2010: Liang Ma; Claudio Mauro; Georgina H Cornish; Jian-Guo Chai; David Coe; Hongmei Fu; Daniel Patton; Klaus Okkenhaug; Guido Franzoso; Julian Dyson; Sussan Nourshargh; Federica M Marelli-Berg
Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(45):19461-6.
2010: Julia Rolf; Sarah E Bell; Dorottya Kovesdi; Michelle L Janas; Dalya R Soond; Louise M C Webb; Sara Santinelli; Ted Saunders; Barbara Hebeis; Nigel Killeen; Klaus Okkenhaug; Martin Turner
Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4042-52.
2010: Elisa Bjørgo; Silje A Solheim; Hilde Abrahamsen; George S Baillie; Kim M Brown; Torunn Berge; Klaus Okkenhaug; Miles D Houslay; Kjetil Taskén
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Molecular and cellular biology 2010;30(7):1660-72.
2010: Dalya R Soond; Elisa Bjørgo; Kristine Moltu; Verity Q Dale; Daniel Patton; Knut Martin Torgersen; Fiona Galleway; Breda Twomey; Jonathan Clark; J S Hill Gaston; Kjetil Taskén; Peter Bunyard; Klaus Okkenhaug
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
Blood 2010;115(11):2203-13.
2010: Faruk Ramadani; Daniel J Bolland; Fabien Garcon; Juliet L Emery; Bart Vanhaesebroeck; Anne E Corcoran; Klaus Okkenhaug
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Science signaling 2010;3(134):ra60.
2010: Klaus Okkenhaug; David A Fruman
PI3Ks in lymphocyte signaling and development.
Current topics in microbiology and immunology 2010;346():57-85.
2009: Robert J Salmond; Juliet Emery; Klaus Okkenhaug; Rose Zamoyska
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7388-97.
2009: Colin Selman; Jennifer M A Tullet; Daniela Wieser; Elaine Irvine; Steven J Lingard; Agharul I Choudhury; Marc Claret; Hind Al-Qassab; Danielle Carmignac; Faruk Ramadani; Angela Woods; Iain C A Robinson; Eugene Schuster; Rachel L Batterham; Sara C Kozma; George Thomas; David Carling; Klaus Okkenhaug; Janet M Thornton; Linda Partridge; David Gems; Dominic J Withers
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Science (New York, N.Y.) 2009;326(5949):140-4.
2009: Dong Liu; Tingting Zhang; Aaron J Marshall; Klaus Okkenhaug; Bart Vanhaesebroeck; Jude E Uzonna
The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1921-33.
2009: Kathrin Gollmer; François Asperti-Boursin; Yoshihiko Tanaka; Klaus Okkenhaug; Bart Vanhaesebroeck; Jeffrey Peterson; Yoshinori Fukui; Emmanuel Donnadieu; Jens V Stein
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway.
Blood 2009;114(3):580-8.
2009: Aurore Saudemont; Fabien Garçon; Hakim Yadi; Marta Roche-Molina; Nayoung Kim; Anne Segonds-Pichon; Alfonso Martín-Fontecha; Klaus Okkenhaug; Francesco Colucci
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5795-800.
2009: Susan Kohlhaas; Oliver A Garden; Cheryl Scudamore; Martin Turner; Klaus Okkenhaug; Elena Vigorito
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2578-82.
2008: Ting-Ting Zhang; Klaus Okkenhaug; Baher F Nashed; Kamal D Puri; Zachary A Knight; Kevan M Shokat; Bart Vanhaesebroeck; Aaron J Marshall
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
The Journal of allergy and clinical immunology 2008;122(4):811-819.e2.
2008: Tea Gogishvili; Fernando Elias; Juliet L Emery; Kirsty McPherson; Klaus Okkenhaug; Thomas Hünig; Kevin M Dennehy
Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.
European journal of immunology 2008;38(9):2528-33.
2008: Julie Guillermet-Guibert; Katja Bjorklof; Ashreena Salpekar; Cristiano Gonella; Faruk Ramadani; Antonio Bilancio; Stephen Meek; Andrew J H Smith; Klaus Okkenhaug; Bart Vanhaesebroeck
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(24):8292-7.
2008: Linda V Sinclair; David Finlay; Carmen Feijoo; Georgina H Cornish; Alex Gray; Ann Ager; Klaus Okkenhaug; Thijs Hagenbeek; Hergen Spits; Doreen A Cantrell
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Nature immunology 2008;9(5):513-21.
2008: Sarah J Jarmin; Rachel David; Liang Ma; Jian-Guo Chai; Hamlata Dewchand; Aya Takesono; Anne J Ridley; Klaus Okkenhaug; Federica M Marelli-Berg
T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.
The Journal of clinical investigation 2008;118(3):1154-64.
2008: Colin Selman; Steven J Lingard; Agharul I Choudhury; Rachel L Batterham; Marc Claret; Melanie Clements; Faruk Ramadani; Klaus Okkenhaug; Eugene Schuster; Eric Blanc; Matthew D W Piper; Hind Al-Qassab; John R Speakman; Danielle Carmignac; Iain C A F Robinson; Janet M Thornton; David Gems; Linda Partridge; Dominic J Withers
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):807-18.
2008: Fabien Garçon; Daniel Patton; Juliet L Emery; Emilio Hirsch; Robert Rottapel; Takehiko Sasaki; Klaus Okkenhaug
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
Blood 2008;111(3):1464-71.
2007: Hong Ji; Felix Rintelen; Caroline Waltzinger; Dominique Bertschy Meier; Antonio Bilancio; Wayne Pearce; Emilio Hirsch; Matthias P Wymann; Thomas Rückle; Montserrat Camps; Bart Vanhaesebroeck; Klaus Okkenhaug; Christian Rommel
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
Blood 2007;110(8):2940-7.
2007: Federica M Marelli-Berg; Klaus Okkenhaug; Vincenzo Mirenda
A two-signal model for T cell trafficking.
Trends in immunology 2007;28(6):267-73.
2007: Antony Rodriguez; Elena Vigorito; Simon Clare; Madhuri V Warren; Philippe Couttet; Dalya R Soond; Stijn van Dongen; Russell J Grocock; Partha P Das; Eric A Miska; David Vetrie; Klaus Okkenhaug; Anton J Enright; Gordon Dougan; Martin Turner; Allan Bradley
Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316(5824):608-11.
2007: Aurore Saudemont; Klaus Okkenhaug; Francesco Colucci
p110delta is required for innate immunity to transplantable lymphomas.
Biochemical Society transactions 2007;35(Pt 2):183-5.
2007: Daniel Patton; Fabien Garçon; Klaus Okkenhaug
The PI3K p110delta controls T-cell development, differentiation and regulation.
Biochemical Society transactions 2007;35(Pt 2):167-71.
2007: Vincenzo Mirenda; Sarah J Jarmin; Rachel David; Julian Dyson; Diane Scott; Yan Gu; Robert I Lechler; Klaus Okkenhaug; Federica M Marelli-Berg
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28.
Blood 2007;109(7):2968-77.
2007: Monther M Al-Alwan; Klaus Okkenhaug; Bart Vanhaesebroeck; Joel S Hayflick; Aaron J Marshall
Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2328-35.
2007: Baher Nashed; Tingting Zhang; Monther M Al-Alwan; Ganesh Srinivasan; Andrew J Halayko; Klaus Okkenhaug; Bart Vanhaesebroeck; Kent T Hayglass; Aaron J Marshall
Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation.
European journal of immunology 2007;37(2):416-24.
2007: Klaus Okkenhaug; Khaled Ali; Bart Vanhaesebroeck
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.
Trends in immunology 2007;28(2):80-7.
2006: Daniel Patton; Oliver A Garden; Wayne P Pearce; Louise E Clough; Clare R Monk; Eva Leung; Wendy C Rowan; Sara Sancho; Lucy S K Walker; Bart Vanhaesebroeck; Klaus Okkenhaug
Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6598-602.
2006: Klaus Okkenhaug; Daniel Patton; Antonio Bilancio; Fabien Garçon; Wendy C Rowan; Bart Vanhaesebroeck
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5122-8.
2006: Lazaros C Foukas; Marc Claret; Wayne Pearce; Klaus Okkenhaug; Stephen Meek; Emma Peskett; Sara Sancho; Andrew J H Smith; Dominic J Withers; Bart Vanhaesebroeck
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
Nature 2006;441(7091):366-70.
2006: Antonio Bilancio; Klaus Okkenhaug; Montserrat Camps; Juliet L Emery; Thomas Ruckle; Christian Rommel; Bart Vanhaesebroeck
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.
Blood 2006;107(2):642-50.
2005: Heidi C E Welch; Alison M Condliffe; Laura Milne; Gordon ferguson; Kirsti Hill; Louise M C Webb; Klaus Okkenhaug; W John Coadwell; Simon R Andrews; Marcus Thelen; Gareth E Jones; Phillip T Hawkins; Len R Stephens
P-Rex1 regulates neutrophil function.
Current biology : CB 2005;15(20):1867-73.
2005: Alison M Condliffe; Keith Davidson; Karen E Anderson; Chris D Ellson; Tom Crabbe; Klaus Okkenhaug; Bart Vanhaesebroeck; Martin Turner; Louise Webb; Matthias P Wymann; Emilio Hirsch; Thomas Ruckle; Montserrat Camps; Christian Rommel; Shaun P Jackson; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Blood 2005;106(4):1432-40.
2005: Yotis A Senis; Ben T Atkinson; Andrew C Pearce; Peter Wonerow; Jocelyn M Auger; Klaus Okkenhaug; Wayne Pearce; Elena Vigorito; Bart Vanhaesebroeck; Martin Turner; Steve P Watson
Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.
Platelets 2005;16(3-4):191-202.
2005: Linda X Wu; Jose La Rose; Liane Chen; Chris Neale; Tak Mak; Klaus Okkenhaug; Ronald Wange; Robert Rottapel
CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):180-94.
2004: Khaled Ali; Antonio Bilancio; Matthew Thomas; Wayne Pearce; Alasdair M Gilfillan; Christine Tkaczyk; Nicolas Kuehn; Alexander Gray; June Giddings; Emma Peskett; Roy Fox; Ian Bruce; Christoph Walker; Carol Sawyer; Klaus Okkenhaug; Peter Finan; Bart Vanhaesebroeck
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.
Nature 2004;431(7011):1007-11.
2004: Karin Reif; Klaus Okkenhaug; Takehiko Sasaki; Josef M Penninger; Bart Vanhaesebroeck; Jason G Cyster
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2236-40.
2004: Klaus Okkenhaug; Antonio Bilancio; J L Emery; Bart Vanhaesebroeck
Phosphoinositide 3-kinase in T cell activation and survival.
Biochemical Society transactions 2004;32(Pt 2):332-5.
2003: Yann Leverrier; Klaus Okkenhaug; Carol Sawyer; Antonio Bilancio; Bart Vanhaesebroeck; Anne J Ridley
Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.
The Journal of biological chemistry 2003;278(40):38437-42.
2003: Lazaros C Foukas; Klaus Okkenhaug
Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases.
Archives of biochemistry and biophysics 2003;414(1):13-8.
2003: Theodossis Theodossiou; John S Hothersall; Elizabeth A Woods; Klaus Okkenhaug; Jake Jacobson; Alexander J MacRobert
Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.
Cancer research 2003;63(8):1818-21.
2003: Klaus Okkenhaug; Bart Vanhaesebroeck
PI3K in lymphocyte development, differentiation and activation.
Nature reviews. Immunology 2003;3(4):317-30.
2003: Klaus Okkenhaug; Bart Vanhaesebroeck
PI3K-signalling in B- and T-cells: insights from gene-targeted mice.
Biochemical Society transactions 2003;31(Pt 1):270-4.
2002: Klaus Okkenhaug; Antonio Bilancio; Géraldine Farjot; Helen Priddle; Sara Sancho; Emma Peskett; Wayne Pearce; Stephen E Meek; Ashreena Salpekar; Michael D Waterfield; Andrew J H Smith; Bart Vanhaesebroeck
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
Science (New York, N.Y.) 2002;297(5583):1031-4.
2001: Klaus Okkenhaug; Linda Wu; K M Garza; Jose La Rose; W Khoo; Bernhard Odermatt; Tak W Mak; Pamela S Ohashi; Robert Rottapel
A point mutation in CD28 distinguishes proliferative signals from survival signals.
Nature immunology 2001;2(4):325-32.
2001: Klaus Okkenhaug; Bart Vanhaesebroeck
New responsibilities for the PI3K regulatory subunit p85 alpha.
Science's STKE : signal transduction knowledge environment 2001;2001(65):pe1.
2001: Roy M Katso; Klaus Okkenhaug; Kourosh R Ahmadi; S White; John Francis Timms; Michael D Waterfield
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.
Annual review of cell and developmental biology 2001;17():615-75.
1999: Paulo de Sepulveda; Klaus Okkenhaug; J L Rose; R G Hawley; Patrice Dubreuil; Robert Rottapel
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
The EMBO journal 1999;18(4):904-15.
1998: Klaus Okkenhaug; Robert Rottapel
Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.
The Journal of biological chemistry 1998;273(33):21194-202.
1997: LE Marengère; Klaus Okkenhaug; A Clavreul; Dominique Couez; S Gibson; Gordon B Mills; Tak W Mak; Robert Rottapel
The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3220-9.