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Cláudio M. Gomes

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Oxidation-Reduction

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Hugo M Botelho; Isabel Cardoso; Günter Fritz; Sónia S Leal; Ludmilla A Morozova-Roche; Kiran Yanamandra; Cláudio M. Gomes
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation.
Ema Alves; Bárbara J Henriques; Rui G Martinho; Pedro Prudêncio; Hugo Rocha; João Rodrigues; Laura Vilarinho; Cláudio M. Gomes
Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila.
João Rodrigues; Cláudio M. Gomes
Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants.

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2012: Hugo M Botelho; Isabel Cardoso; Günter Fritz; Sónia S Leal; Ludmilla A Morozova-Roche; Kiran Yanamandra; Cláudio M. Gomes
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation.
The Journal of biological chemistry 2012;287(50):42233-42.
2012: Ema Alves; Bárbara J Henriques; Rui G Martinho; Pedro Prudêncio; Hugo Rocha; João Rodrigues; Laura Vilarinho; Cláudio M. Gomes
Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila.
Biochimica et biophysica acta 2012;1822(8):1284-92.
2012: João Rodrigues; Cláudio M. Gomes
Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants.
Free radical biology & medicine 2012;53(1):12-9.
2012: Andreas Veith; Hugo M Botelho; Cláudio M. Gomes; Florian Kindinger; Arnulf Kletzin
The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme.
Journal of bacteriology 2012;194(3):677-85.
2012: Hugo M Botelho; Günter Fritz; Cláudio M. Gomes
Analysis of S100 oligomers and amyloids.
Methods in molecular biology (Clifton, N.J.) 2012;849():373-86.
2011: Tânia G Lucas; João Rodrigues; Peter Bross; Niels Gregersen; Bárbara J Henriques; Cláudio M. Gomes
Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases.
Biochimica et biophysica acta 2011;1812(12):1658-63.
2011: João Rodrigues; Isabel Marrucho; Vesna Prosinecki; Luís P N Rebelo; Cláudio M. Gomes
Protein stability in an ionic liquid milieu: on the use of differential scanning fluorimetry.
Physical chemistry chemical physics : PCCP 2011;13(30):13614-6.
2011: Bárbara J Henriques; Mark T Fisher; Peter Bross; Cláudio M. Gomes
A polymorphic position in electron transfer flavoprotein modulates kinetic stability as evidenced by thermal stress.
FEBS letters 2011;585(3):505-10.
2010: Günter Fritz; Hugo M Botelho; Ludmilla A Morozova-Roche; Cláudio M. Gomes
Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.
The FEBS journal 2010;277(22):4578-90.
2010: Bárbara J Henriques; Peter Bross; Cláudio M. Gomes
Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency.
Biochimica et biophysica acta 2010;1802(11):1070-7.
2010: Joana D Amaral; Ana R Correia; Clifford J Steer; Cláudio M. Gomes; Cecília M P Rodrigues
No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain.
Bioscience reports 2010;30(5):359-64.
2010: João Rodrigues; Cláudio M. Gomes
Enhanced superoxide and hydrogen peroxide detection in biological assays.
Free radical biology & medicine 2010;49(1):61-6.
2010: SoHui Kim; Sónia S Leal; Daniel Ben Halevy; Cláudio M. Gomes; Sima Lev
Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.
The Journal of biological chemistry 2010;285(18):13839-49.
2010: Ana R Correia; Tao Wang; Elizabeth A Craig; Cláudio M. Gomes
Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.
The Biochemical journal 2010;426(2):197-203.
2010: Hugo M Botelho; Sónia S Leal; Andreas Veith; Vesna Prosinecki; Christian Bauer; Renate Fröhlich; Arnulf Kletzin; Cláudio M. Gomes
Role of a novel disulfide bridge within the all-beta fold of soluble Rieske proteins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(2):271-81.
2010: Bárbara J Henriques; Rikke K Olsen; Peter Bross; Cláudio M. Gomes
Emerging roles for riboflavin in functional rescue of mitochondrial β-oxidation flavoenzymes.
Current medicinal chemistry 2010;17(32):3842-54.
2009: Ana R Correia; Saw Y Ow; Phillip C Wright; Cláudio M. Gomes
The conserved Trp155 in human frataxin as a hotspot for oxidative stress related chemical modifications.
Biochemical and biophysical research communications 2009;390(3):1007-11.
2009: Barbara Boscolo; Sónia S Leal; Carlos A Salgueiro; Elena Ghibaudi; Cláudio M. Gomes
The prominent conformational plasticity of lactoperoxidase: a chemical and pH stability analysis.
Biochimica et biophysica acta 2009;1794(7):1041-8.
2009: Hugo M Botelho; Michael Koch; Günter Fritz; Cláudio M. Gomes
Metal ions modulate the folding and stability of the tumor suppressor protein S100A2.
The FEBS journal 2009;276(6):1776-86.
2009: Bárbara J Henriques; João Rodrigues; Rikke K Olsen; Peter Bross; Cláudio M. Gomes
Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation.
The Journal of biological chemistry 2009;284(7):4222-9.
2008: Patrícia F N Faísca; Cláudio M. Gomes
On the relation between native geometry and conformational plasticity.
Biophysical chemistry 2008;138(3):99-106.
2008: Meike Stelter; Ana M P Melo; Manuela M Pereira; Cláudio M. Gomes; Gudmundur O Hreggvidsson; Sigridur Hjorleifsdottir; Lígia M Saraiva; Miguel Teixeira; Margarida Archer
A novel type of monoheme cytochrome c: biochemical and structural characterization at 1.23 A resolution of rhodothermus marinus cytochrome c.
Biochemistry 2008;47(46):11953-63.
2008: Sónia S Leal; Cláudio M. Gomes
On the relative contribution of ionic interactions over iron-sulfur clusters to ferredoxin stability.
Biochimica et biophysica acta 2008;1784(11):1596-600.
2008: Ricardo M Gouveia; Cláudio M. Gomes; Marcos Sousa; Paula M Alves; Júlia Costa
Kinetic analysis of L1 homophilic interaction: role of the first four immunoglobulin domains and implications on binding mechanism.
The Journal of biological chemistry 2008;283(42):28038-47.
2008: Paula Leandro; Cláudio M. Gomes
Protein misfolding in conformational disorders: rescue of folding defects and chemical chaperoning.
Mini reviews in medicinal chemistry 2008;8(9):901-11.
2008: Ana R Correia; Chiara Pastore; Salvatore Adinolfi; Annalisa Pastore; Cláudio M. Gomes
Dynamics, stability and iron-binding activity of frataxin clinical mutants.
The FEBS journal 2008;275(14):3680-90.
2008: Carlos Frazão; David Aragao; Ricardo Coelho; Sónia S Leal; Cláudio M. Gomes; Miguel Teixeira; Maria Arménia Carrondo
Crystallographic analysis of the intact metal centres [3Fe-4S](1+/0) and [4Fe-4S](2+/1+) in a Zn(2+) -containing ferredoxin.
FEBS letters 2008;582(5):763-7.
2007: Márcia Almeida Liz; Cláudio M. Gomes; Maria João Saraiva; Mónica Mendes Sousa
ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity.
Journal of lipid research 2007;48(11):2385-95.
2007: Smilja Todorovic; Sónia S Leal; Carlos A Salgueiro; Ingo Zebger; Peter Hildebrandt; Daniel H Murgida; Cláudio M. Gomes
A spectroscopic study of the temperature induced modifications on ferredoxin folding and iron-sulfur moieties.
Biochemistry 2007;46(37):10733-8.
2007: Barbara Boscolo; Sónia S Leal; Elena Ghibaudi; Cláudio M. Gomes
Lactoperoxidase folding and catalysis relies on the stabilization of the alpha-helix rich core domain: a thermal unfolding study.
Biochimica et biophysica acta 2007;1774(9):1164-72.
2007: Sónia S Leal; Cláudio M. Gomes
Studies of the molten globule state of ferredoxin: structural characterization and implications on protein folding and iron-sulfur center assembly.
Proteins 2007;68(3):606-16.
2006: Vesna Prosinecki; Hugo M Botelho; Simona Francese; Guido Mastrobuoni; Gloriano Moneti; Tim Urich; Arnulf Kletzin; Cláudio M. Gomes
A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability.
Journal of proteome research 2006;5(10):2720-6.
2006: Ana R Correia; Salvatore Adinolfi; Annalisa Pastore; Cláudio M. Gomes
Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding.
The Biochemical journal 2006;398(3):605-11.
2006: Rita Rocha; Sónia S Leal; Vitor H Teixeira; Manuela Regalla; Harald Huber; António M Baptista; Cláudio M Soares; Cláudio M. Gomes
Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site.
Biochemistry 2006;45(34):10376-84.
2006: Tim Urich; Cláudio M. Gomes; Arnulf Kletzin; Carlos Frazão
X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme.
Science (New York, N.Y.) 2006;311(5763):996-1000.
2006: Bárbara J Henriques; Lígia M Saraiva; Cláudio M. Gomes
Combined spectroscopic and calorimetric characterisation of rubredoxin reversible thermal transition.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(1):73-81.
2005: Sónia S Leal; Cláudio M. Gomes
Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins.
Biological chemistry 2005;386(12):1295-300.
2005: Bárbara J Henriques; Lígia M Saraiva; Cláudio M. Gomes
Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments.
Biochemical and biophysical research communications 2005;333(3):839-44.
2005: Arnulf Kletzin; Ana S Ferreira; Torsten Hechler; Tiago M Bandeiras; Miguel Teixeira; Cláudio M. Gomes
A Rieske ferredoxin typifying a subtype within Rieske proteins: spectroscopic, biochemical and stability studies.
FEBS letters 2005;579(5):1020-6.
2004: Sónia S Leal; Miguel Teixeira; Cláudio M. Gomes
Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: cluster dissociation, iron release and protein stability.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):987-96.
2004: Fabian H Müller; Tiago M Bandeiras; Tim Urich; Miguel Teixeira; Cláudio M. Gomes; Arnulf Kletzin
Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase.
Molecular microbiology 2004;53(4):1147-60.
2004: Tim Urich; Tiago M Bandeiras; Sónia S Leal; Reinhard Rachel; Till Albrecht; Peter Zimmermann; Corinna Scholz; Miguel Teixeira; Cláudio M. Gomes; Arnulf Kletzin
The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre.
The Biochemical journal 2004;381(Pt 1):137-46.
2004: Tapan Kanti Das; Cláudio M. Gomes; Tiago M Bandeiras; Manuela M Pereira; Miguel Teixeira; Denis L Rousseau
Active site structure of the aa3 quinol oxidase of Acidianus ambivalens.
Biochimica et biophysica acta 2004;1655(1-3):306-20.
2004: Arnulf Kletzin; Tim Urich; Fabian Müller; Tiago M Bandeiras; Cláudio M. Gomes
Dissimilatory oxidation and reduction of elemental sulfur in thermophilic archaea.
Journal of bioenergetics and biomembranes 2004;36(1):77-91.
2003: Petra Hellwig; Cláudio M. Gomes; Miguel Teixeira
FTIR spectroscopic characterization of the cytochrome aa3 from Acidianus ambivalens: evidence for the involvement of acidic residues in redox coupled proton translocation.
Biochemistry 2003;42(20):6179-84.
2003: Bruno L Victor; João B Vicente; Rute Rodrigues; Solange Oliveira; Claudina Rodrigues-Pousada; Carlos Frazão; Cláudio M. Gomes; Miguel Teixeira; Cláudio M Soares
Docking and electron transfer studies between rubredoxin and rubredoxin:oxygen oxidoreductase.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(4):475-88.
2003: Tiago M Bandeiras; Carlos A Salgueiro; Harald Huber; Cláudio M. Gomes; Miguel Teixeira
The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: studies on the type-II NADH dehydrogenase.
Biochimica et biophysica acta 2003;1557(1-3):13-9.
2002: Tiago M Bandeiras; Carlos A Salgueiro; Arnulf Kletzin; Cláudio M. Gomes; Miguel Teixeira
Acidianus ambivalens type-II NADH dehydrogenase: genetic characterisation and identification of the flavin moiety as FMN.
FEBS letters 2002;531(2):273-7.
2002: Cláudio M. Gomes; Alessandro Giuffrè; Elena Forte; João B Vicente; Lígia M Saraiva; Maurizio Brunori; Miguel Teixeira
A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin.
The Journal of biological chemistry 2002;277(28):25273-6.
2002: Manuela M Pereira; Cláudio M. Gomes; Miguel Teixeira
Plasticity of proton pathways in haem-copper oxygen reductases.
FEBS letters 2002;522(1-3):14-8.
2002: João B Vicente; Cláudio M. Gomes; Alain Wasserfallen; Miguel Teixeira
Module fusion in an A-type flavoprotein from the cyanobacterium Synechocystis condenses a multiple-component pathway in a single polypeptide chain.
Biochemical and biophysical research communications 2002;294(1):82-7.
2002: Cláudio M. Gomes; Arnulf Kletzin; Miguel Teixeira
An archaeal b-type cytochrome containing a nonfunctional carbonic anhydrase-like domain.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):483-9.
2002: Kathryn Jones; Cláudio M. Gomes; Harald Huber; Miguel Teixeira; Pernilla Wittung-Stafshede
Formation of a linear [3Fe-4S] cluster in a seven-iron ferredoxin triggered by polypeptide unfolding.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):357-62.
2002: Cláudio M. Gomes; Carlos Frazão; António V Xavier; Jean Legall; Miguel Teixeira
Functional control of the binuclear metal site in the metallo-beta-lactamase-like fold by subtle amino acid replacements.
Protein science : a publication of the Protein Society 2002;11(3):707-12.
2002: Rita S Lemos; Cláudio M. Gomes; Jean Legall; António V Xavier; Miguel Teixeira
The quinol:fumarate oxidoreductase from the sulphate reducing bacterium Desulfovibrio gigas: spectroscopic and redox studies.
Journal of bioenergetics and biomembranes 2002;34(1):21-30.
2002: Rita S Lemos; Andreia S Fernandes; Manuela M Pereira; Cláudio M. Gomes; Miguel Teixeira
Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment.
Biochimica et biophysica acta 2002;1553(1-2):158-70.
2001: Cláudio M. Gomes; J Le Gall; António V Xavier; Miguel Teixeira
Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?
Chembiochem : a European journal of chemical biology 2001;2(7-8):583-7.
2001: CK Moczygemba; Jesse Guidry; K L Jones; Cláudio M. Gomes; Miguel Teixeira; Pernilla Wittung-Stafshede
High stability of a ferredoxin from the hyperthermophilic archaeon A. ambivalens: involvement of electrostatic interactions and cofactors.
Protein science : a publication of the Protein Society 2001;10(8):1539-48.
2001: Cláudio M. Gomes; C Backgren; Miguel Teixeira; Anne Puustinen; Marina L Verkhovskaya; Mårten Wikström; Michael I Verkhovsky
Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps.
FEBS letters 2001;497(2-3):159-64.
2001: Rita S Lemos; Cláudio M. Gomes; Margarida Santana; Jean Legall; António V Xavier; Miguel Teixeira
The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain.
FEBS letters 2001;496(1):40-3.
2001: Rita S Lemos; Cláudio M. Gomes; Miguel Teixeira
Acidianus ambivalens Complex II typifies a novel family of succinate dehydrogenases.
Biochemical and biophysical research communications 2001;281(1):141-50.
2001: Cláudio M. Gomes; Tiago M Bandeiras; Miguel Teixeira
A new type-II NADH dehydrogenase from the archaeon Acidianus ambivalens: characterization and in vitro reconstitution of the respiratory chain.
Journal of bioenergetics and biomembranes 2001;33(1):1-8.
2001: Gwen Gilderson; Anna Aagaard; Cláudio M. Gomes; Pia Adelroth; M Teixeira; Peter Brzezinski
Kinetics of electron and proton transfer during O(2) reduction in cytochrome aa(3) from A. ambivalens: an enzyme lacking Glu(I-286).
Biochimica et biophysica acta 2001;1503(3):261-70.
2000: Cláudio M. Gomes; João B Vicente; A Wasserfallen; Miguel Teixeira
Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner.
Biochemistry 2000;39(51):16230-7.
2000: Carlos Frazão; G Silva; Cláudio M. Gomes; Pedro M Matias; Ricardo Coelho; Larry Sieker; Sofia Macedo; Ming Y Liu; Solange Oliveira; Miguel Teixeira; António V Xavier; Claudina Rodrigues-Pousada; Maria Arménia Carrondo; J Le Gall
Structure of a dioxygen reduction enzyme from Desulfovibrio gigas.
Nature structural biology 2000;7(11):1041-5.
2000: Pernilla Wittung-Stafshede; Cláudio M. Gomes; Miguel Teixeira
Stability and folding of the ferredoxin from the hyperthermophilic archaeon Acidianus ambivalens.
Journal of inorganic biochemistry 2000;78(1):35-41.
1999: TK Das; Cláudio M. Gomes; Miguel Teixeira; Denis L Rousseau
Redox-linked transient deprotonation at the binuclear site in the aa(3)-type quinol oxidase from Acidianus ambivalens: implications for proton translocation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9591-6.
1999: Anna Aagaard; Gwen Gilderson; Cláudio M. Gomes; M Teixeira; Peter Brzezinski
Dynamics of the binuclear center of the quinol oxidase from Acidianus ambivalens.
Biochemistry 1999;38(31):10032-41.
1999: Cláudio M. Gomes; Rita S Lemos; Miguel Teixeira; Arnulf Kletzin; Harald Huber; K O Stetter; Günter Schäfer; Stefan Anemüller
The unusual iron sulfur composition of the Acidianus ambivalens succinate dehydrogenase complex.
Biochimica et biophysica acta 1999;1411(1):134-41.
1999: Célia V Romão; Ming Y Liu; J Le Gall; Cláudio M. Gomes; V Braga; Isabel Pacheco; António V Xavier; Miguel Teixeira
The superoxide dismutase activity of desulfoferrodoxin from Desulfovibrio desulfuricans ATCC 27774.
European journal of biochemistry / FEBS 1999;261(2):438-43.
1999: G Silva; Solange Oliveira; Cláudio M. Gomes; Isabel Pacheco; Ming Y Liu; António V Xavier; Miguel Teixeira; Jean Legall; Claudina Rodrigues-Pousada
Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe.
European journal of biochemistry / FEBS 1999;259(1-2):235-43.
1998: Cláudio M. Gomes; Miguel Teixeira
Ambineela, an unusual blue protein isolated from the archaeon Acidianus ambivalens.
Biochemical and biophysical research communications 1998;249(1):23-5.
1998: Cláudio M. Gomes; Harald Huber; K O Stetter; Miguel Teixeira
Evidence for a novel type of iron cluster in the respiratory chain of the archaeon Sulfolobus metallicus.
FEBS letters 1998;432(3):99-102.
1998: Jean Legall; Ming Y Liu; Cláudio M. Gomes; V Braga; Isabel Pacheco; Manuela Regalla; António V Xavier; Miguel Teixeira
Characterisation of a new rubredoxin isolated from Desulfovibrio desulfuricans 27774: definition of a new family of rubredoxins.
FEBS letters 1998;429(3):295-8.
1998: Cláudio M. Gomes; Miguel Teixeira
The NADH oxidase from the thermoacidophilic archaea Acidianus ambivalens: isolation and physicochemical characterisation.
Biochemical and biophysical research communications 1998;243(2):412-5.
1997: Alessandro Giuffrè; Cláudio M. Gomes; Giovanni Antonini; Emilio D'Itri; Miguel Teixeira; Maurizio Brunori
Functional properties of the quinol oxidase from Acidianus ambivalens and the possible catalytic role of its electron donor--studies on the membrane-integrated and purified enzyme.
European journal of biochemistry / FEBS 1997;250(2):383-8.
1997: Cláudio M. Gomes; G Silva; Solange Oliveira; Jean Legall; Ming Y Liu; António V Xavier; Claudina Rodrigues-Pousada; Miguel Teixeira
Studies on the redox centers of the terminal oxidase from Desulfovibrio gigas and evidence for its interaction with rubredoxin.
The Journal of biological chemistry 1997;272(36):22502-8.
1995: Miguel Teixeira; R Batista; A P Campos; Cláudio M. Gomes; J Mendes; Isabel Pacheco; S Anemuller; W R Hagen
A seven-iron ferredoxin from the thermoacidophilic archaeon Desulfurolobus ambivalens.
European journal of biochemistry / FEBS 1995;227(1-2):322-7.