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Moira Bruce

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Diane L Ritchie; Aileen Boyle; Irene McConnell; Mark W Head; James W Ironside; Moira E Bruce
Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice.
Karen L Brown; Gwennaelle J Wathne; Jill Sales; Moira E Bruce; Neil A Mabbott
The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice.
David F Bibby; Andrew C Gill; Louise Kirby; Christine F Farquhar; Moira E Bruce; Jeremy A Garson
Application of a novel in vitro selection technique to isolate and characterise high affinity DNA aptamers binding mammalian prion proteins.

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2009: Diane L Ritchie; Aileen Boyle; Irene McConnell; Mark W Head; James W Ironside; Moira E Bruce
Transmissions of variant Creutzfeldt-Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice.
The Journal of general virology 2009;90(Pt 12):3075-82.
2009: Karen L Brown; Gwennaelle J Wathne; Jill Sales; Moira E Bruce; Neil A Mabbott
The effects of host age on follicular dendritic cell status dramatically impair scrapie agent neuroinvasion in aged mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5199-207.
2008: David F Bibby; Andrew C Gill; Louise Kirby; Christine F Farquhar; Moira E Bruce; Jeremy A Garson
Application of a novel in vitro selection technique to isolate and characterise high affinity DNA aptamers binding mammalian prion proteins.
Journal of virological methods 2008;151(1):107-15.
2007: Moira E Bruce; Romolo Nonno; James Foster; Wilfred Goldmann; Michele Angelo Di Bari; Elena Esposito; Sylvie Benestad; Nora Hunter; Umberto Agrimi
Nor98-like sheep scrapie in the United Kingdom in 1989.
The Veterinary record 2007;160(19):665-6.
2006: Helen Yull; Diane L Ritchie; Jan P M Langeveld; Fred G van Zijderveld; Moira E Bruce; James W Ironside; Mark W Head
Detection of type 1 prion protein in variant Creutzfeldt-Jakob disease.
The American journal of pathology 2006;168(1):151-7.
2006: Michelle Ierna; Christine F Farquhar; George W Outram; Moira E Bruce
Resistance of neonatal mice to scrapie is associated with inefficient infection of the immature spleen.
Journal of virology 2006;80(1):474-82.
2005: Joanne Mohan; Moira E Bruce; Neil A Mabbott
Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin.
Immunology 2005;114(2):225-34.
2005: Joanne Mohan; Moira E Bruce; Neil A Mabbott
Neuroinvasion by scrapie following inoculation via the skin is independent of migratory Langerhans cells.
Journal of virology 2005;79(3):1888-97.
2004: Joanne Mohan; Karen L Brown; Christine F Farquhar; Moira E Bruce; Neil A Mabbott
Scrapie transmission following exposure through the skin is dependent on follicular dendritic cells in lymphoid tissues.
Journal of dermatological science 2004;35(2):101-11.
2004: Gillian McGovern; KL Brown; Moira E Bruce; Martin Jeffrey
Murine scrapie infection causes an abnormal germinal centre reaction in the spleen.
Journal of comparative pathology 2004;130(2-3):181-94.
2004: Neil A Mabbott; Moira E Bruce
Complement component C5 is not involved in scrapie pathogenesis.
Immunobiology 2004;209(7):545-9.
2003: Neil A Mabbott; Moira E Bruce
Prion disease: bridging the spleen-nerve gap.
Nature medicine 2003;9(12):1463-4.
2003: D A Brown; Moira E Bruce; Janet R Fraser
Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice.
Neuropathology and applied neurobiology 2003;29(3):262-72.
2003: Neil A Mabbott; Janice Young; Irene McConnell; Moira E Bruce
Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility.
Journal of virology 2003;77(12):6845-54.
2003: Moira E Bruce
TSE strain variation.
British medical bulletin 2003;66():99-108.
2002: Neil A Mabbott; Moira E Bruce
Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies.
Seminars in immunology 2002;14(4):285-93.
2002: Neil A Mabbott; Gillian McGovern; Martin Jeffrey; Moira E Bruce
Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain.
Journal of virology 2002;76(10):5131-9.
2002: Moira E Bruce; Aileen Boyle; Simon Cousens; Irene McConnell; James Foster; Wilfred Goldmann; Hugh Fraser
Strain characterization of natural sheep scrapie and comparison with BSE.
The Journal of general virology 2002;83(Pt 3):695-704.
2002: Fang-Ping Huang; Christine F Farquhar; Neil A Mabbott; Moira E Bruce; G Gordon MacPherson
Migrating intestinal dendritic cells transport PrP(Sc) from the gut.
The Journal of general virology 2002;83(Pt 1):267-71.
2001: Neil A Mabbott; Moira E Bruce
The immunobiology of TSE diseases.
The Journal of general virology 2001;82(Pt 10):2307-18.
2001: Moira E Bruce; Irene McConnell; Robert G Will; James W Ironside
Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues.
Lancet 2001;358(9277):208-9.
2001: Christopher R Birkett; RM Hennion; D A Bembridge; M C Clarke; A Chree; Moira E Bruce; Christopher J Bostock
Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.
The EMBO journal 2001;20(13):3351-8.
2001: Neil A Mabbott; Moira E Bruce; M Botto; M J Walport; M B Pepys
Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.
Nature medicine 2001;7(4):485-7.
2000: Moira E Bruce; Karen L Brown; Neil A Mabbott; Christine F Farquhar; Martin Jeffrey
Follicular dendritic cells in TSE pathogenesis.
Immunology today 2000;21(9):442-6.
2000: Neil A Mabbott; F Mackay; F Minns; Moira E Bruce
Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie.
Nature medicine 2000;6(7):719-20.
2000: Martin Jeffrey; Gillian McGovern; Caroline M Goodsir; KL Brown; Moira E Bruce
Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy.
The Journal of pathology 2000;191(3):323-32.
2000: Karen L Brown; Diane L Ritchie; P A McBride; Moira E Bruce
Detection of PrP in extraneural tissues.
Microscopy research and technique 2000;50(1):40-5.
2000: Neil A Mabbott; A Williams; Christine F Farquhar; M Pasparakis; george kollias; Moira E Bruce
Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie.
Journal of virology 2000;74(7):3338-44.
2000: Karen L Brown; K Stewart; D Ritchie; Hugh Fraser; W I Morrison; Moira E Bruce
Follicular dendritic cells in scrapie pathogenesis.
Archives of virology. Supplementum 2000;(16):13-21.
1999: Karen L Brown; K Stewart; Diane L Ritchie; Neil A Mabbott; A Williams; Hugh Fraser; W I Morrison; Moira E Bruce
Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells.
Nature medicine 1999;5(11):1308-12.
1999: James Hope; S C Wood; Christopher R Birkett; Angela Chong; Moira E Bruce; D Cairns; Wilfred Goldmann; Nora Hunter; Christopher J Bostock
Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641.
The Journal of general virology 1999;80 ( Pt 1)():1-4.
1998: Martin Jeffrey; Caroline M Goodsir; Andrew Holliman; RJ Higgins; Moira E Bruce; P A McBride; Janet R Fraser
Determination of the frequency and distribution of vascular and parenchymal amyloid with polyclonal and N-terminal-specific PrP antibodies in scrapie-affected sheep and mice.
The Veterinary record 1998;142(20):534-7.
1998: Neil A Mabbott; Christine F Farquhar; Karen L Brown; Moira E Bruce
Involvement of the immune system in TSE pathogenesis.
Immunology today 1998;19(5):201-3.
1998: P A McBride; M I Wilson; Piet Eikelenboom; A Tunstall; Moira E Bruce
Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathology throughout the incubation period of scrapie-infected mice.
Experimental neurology 1998;149(2):447-54.
1998: Christine F Farquhar; Robert A Somerville; Moira E Bruce
Straining the prion hypothesis.
Nature 1998;391(6665):345-6.
1997: Moira E Bruce; Robert G Will; James W Ironside; Irene McConnell; Dawn Drummond; A Suttie; Linda McCardle; A Chree; James Hope; Christopher R Birkett; S Cousens; Hugh Fraser; Christopher J Bostock
Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent.
Nature 1997;389(6650):498-501.
1997: Neil A Mabbott; Karen L Brown; J Manson; Moira E Bruce
T-lymphocyte activation and the cellular form of the prion protein.
Immunology 1997;92(2):161-5.
1997: Karen L Brown; K Stewart; Moira E Bruce; Hugh Fraser
Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy.
The Journal of general virology 1997;78 ( Pt 10)():2707-10.
1997: Janet R Fraser; J Brown; Moira E Bruce; Martin Jeffrey
Scrapie-induced neuron loss is reduced by treatment with basic fibroblast growth factor.
Neuroreport 1997;8(9-10):2405-9.
1997: Neil A Mabbott; Karen L Brown; Moira E Bruce
T lymphocyte activation and the cellular form of the prion protein, PrPc.
Biochemical Society transactions 1997;25(2):307S.
1997: Karen L Brown; K Stewart; Moira E Bruce; Hugh Fraser
Scrapie in immunodeficient mice.
Biochemical Society transactions 1997;25(2):173S.
1997: Martin Jeffrey; Caroline M Goodsir; Moira E Bruce; P A McBride; Janet R Fraser
In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies.
Neuropathology and applied neurobiology 1997;23(2):93-101.
1996: Martin Jeffrey; Caroline M Goodsir; N Fowler; J Hope; Moira E Bruce; P A McBride
Ultrastructural immuno-localization of synthetic prion protein peptide antibodies in 87V murine scrapie.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(1):101-9.
1994: Martin Jeffrey; Caroline M Goodsir; Moira E Bruce; P A McBride; Christine F Farquhar
Morphogenesis of amyloid plaques in 87V murine scrapie.
Neuropathology and applied neurobiology 1994;20(6):535-42.
1994: Martin Jeffrey; Caroline M Goodsir; Moira E Bruce; P A McBride; J R Scott
Infection-specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie-infected mice.
Annals of the New York Academy of Sciences 1994;724():327-30.
1994: Martin Jeffrey; Caroline M Goodsir; Moira E Bruce; P A McBride; N Fowler; J R Scott
Murine scrapie-infected neurons in vivo release excess prion protein into the extracellular space.
Neuroscience letters 1994;174(1):39-42.
1994: Moira E Bruce; P A McBride; Martin Jeffrey; J R Scott
PrP in pathology and pathogenesis in scrapie-infected mice.
Molecular neurobiology 1994;8(2-3):105-12.
1992: P A McBride; Piet Eikelenboom; Georg Kraal; Hugh Fraser; Moira E Bruce
PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice.
The Journal of pathology 1992;168(4):413-8.
1992: Martin Jeffrey; Caroline M Goodsir; Moira E Bruce; P A McBride; J R Scott; W G Halliday
Infection specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie infected mice.
Neuroscience letters 1992;147(1):106-9.
1992: Hugh Fraser; Moira E Bruce; A Chree; I McConnell; G A Wells
Transmission of bovine spongiform encephalopathy and scrapie to mice.
The Journal of general virology 1992;73 ( Pt 8)():1891-7.
1991: Moira E Bruce; Hugh Fraser
Scrapie strain variation and its implications.
Current topics in microbiology and immunology 1991;172():125-38.
1991: Piet Eikelenboom; J M Rozemuller; Georg Kraal; F C Stam; P A McBride; Moira E Bruce; Hugh Fraser
Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process.
Virchows Archiv. B, Cell pathology including molecular pathology 1991;60(5):329-36.
1989: Moira E Bruce; P A McBride; Christine F Farquhar
Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie.
Neuroscience letters 1989;102(1):1-6.
1989: Hugh Fraser; Moira E Bruce; P A McBride; J R Scott
The molecular pathology of scrapie and the biological basis of lesion targeting.
Progress in clinical and biological research 1989;317():637-44.
1988: P A McBride; Moira E Bruce; Hugh Fraser
Immunostaining of scrapie cerebral amyloid plaques with antisera raised to scrapie-associated fibrils (SAF).
Neuropathology and applied neurobiology 1988;14(4):325-36.
1987: Piet Eikelenboom; J R Scott; P A McBride; J M Rozemuller; Moira E Bruce; Hugh Fraser
No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice. An immunohistoperoxidase study.
Virchows Archiv. B, Cell pathology including molecular pathology 1987;53(4):251-6.