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Mark Guthridge

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Chemicals & Drugs

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Publications

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Daniel Thomas; Andrew H Wei; Joanna Woodcock; Andrew C W Zannettino; Emma F Barry; Paul G Ekert; Stephen Fitter; Benjamin D Green; Timothy P Hughes; Angel F Lopez; Yuefang Ma; Stuart M Pitson; Jason A Powell; Peter R Shepherd; Mark A Guthridge
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.
P S Cheah; P Coyle; Mark A Guthridge; A F Lopez; S Martin; Hayley Ramshaw; Frank C Stomski; Paul Q Thomas; K Toyo-Oka; M van den Buuse; A Wynshaw-Boris; X Xu; Q P Schwarz
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
J J Sandow; John Silke; Frank C Stomski; M R Condina; C P Daunt; B D Green; Mark A Guthridge; P Hoffmann; Anissa M Jabbour; Angel F Lopez; Christopher D Riffkin; Paul G Ekert
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death.

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All Publications

2013: Daniel Thomas; Andrew H Wei; Joanna Woodcock; Andrew C W Zannettino; Emma F Barry; Paul G Ekert; Stephen Fitter; Benjamin D Green; Timothy P Hughes; Angel F Lopez; Yuefang Ma; Stuart M Pitson; Jason A Powell; Peter R Shepherd; Mark A Guthridge
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.
PLoS biology 2013;11(3):e1001515.
2012: P S Cheah; P Coyle; Mark A Guthridge; A F Lopez; S Martin; Hayley Ramshaw; Frank C Stomski; Paul Q Thomas; K Toyo-Oka; M van den Buuse; A Wynshaw-Boris; X Xu; Q P Schwarz
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
Molecular psychiatry 2012;17(4):451-66.
2012: J J Sandow; John Silke; Frank C Stomski; M R Condina; C P Daunt; B D Green; Mark A Guthridge; P Hoffmann; Anissa M Jabbour; Angel F Lopez; Christopher D Riffkin; Paul G Ekert
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death.
Cell death and differentiation 2012;19(4):633-41.
2007: Hayley Ramshaw; Mark A Guthridge; Frank C Stomski; Emma F Barry; Lisa Ooms; Christina A Mitchell; C Glenn Begley; Angel F Lopez
The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis.
Blood 2007;110(10):3582-90.
2007: Mark A Guthridge; Angel F Lopez
Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?
Biochemical Society transactions 2007;35(Pt 2):250-2.
2006: Mark A Guthridge; Jason A Powell; Emma F Barry; Frank C Stomski; Barbara J McClure; Hayley Ramshaw; Fernando A Felquer; Mara Dottore; Daniel T Thomas; Bik To; C Glenn Begley; Angel F Lopez
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.
The EMBO journal 2006;25(3):479-89.
2005: Daniel Thomas; Mark A Guthridge; Joanna M Woodcock; Angel Lopez
14-3-3 protein signaling in development and growth factor responses.
Current topics in developmental biology 2005;67():285-303.
2004: Mark A Guthridge; Emma F Barry; Fernando A Felquer; Barbara J McClure; Frank C Stomski; Hayley Ramshaw; Angel F Lopez
The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.
Blood 2004;103(3):820-7.
2003: Monilola A Olayioye; Mark A Guthridge; Frank C Stomski; Angel F Lopez; Jane E Visvader; Geoffrey J Lindeman
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
The Journal of biological chemistry 2003;278(35):32929-35.
2001: Christopher J Bagley; Joanna M Woodcock; Mark A Guthridge; Frank C Stomski; Angel F Lopez
Structural and functional hot spots in cytokine receptors.
International journal of hematology 2001;73(3):299-307.
2000: Mark A Guthridge; Frank C Stomski; Emma F Barry; W Winnall; Joanna M Woodcock; Barbara J McClure; Mara Dottore; Michael C Berndt; Angel F Lopez
Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.
Molecular cell 2000;6(1):99-108.
1999: Frank C Stomski; Mara Dottore; W Winnall; Mark A Guthridge; Joanna M Woodcock; Christopher J Bagley; D T Thomas; R K Andrews; Michael C Berndt; Angel F Lopez
Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF.
Blood 1999;94(6):1933-42.
1998: Mark A Guthridge; Frank C Stomski; D Thomas; Joanna M Woodcock; Christopher J Bagley; Michael C Berndt; Angel F Lopez
Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors.
Stem cells (Dayton, Ohio) 1998;16(5):301-13.