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David Grundy

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Paul Enck; David Grundy; Sibylle Klosterhalfen
A novel placebo-controlled clinical study design without ethical concerns - the free choice paradigm.
J Donovan; David Grundy
Endocannabinoid modulation of jejunal afferent responses to LPS.
Michael Schemann; Wen Jiang; Eva Maria Kugler; Sabine Buhner; Jemma Donovan; Christopher Eastwood; David Grundy
The mast cell degranulator compound 48/80 directly activates neurons.

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All Publications

2012: Paul Enck; David Grundy; Sibylle Klosterhalfen
A novel placebo-controlled clinical study design without ethical concerns - the free choice paradigm.
Medical hypotheses 2012;79(6):880-2.
2012: J Donovan; David Grundy
Endocannabinoid modulation of jejunal afferent responses to LPS.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2012;24(10):956-e465.
2012: Michael Schemann; Wen Jiang; Eva Maria Kugler; Sabine Buhner; Jemma Donovan; Christopher Eastwood; David Grundy
The mast cell degranulator compound 48/80 directly activates neurons.
PloS one 2012;7(12):e52104.
2011: Christopher Keating; Carlos M Martínez; Pablo Pelegrin; David Grundy
P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1467-74.
2011: David Grundy
TRPs along the alimentary canal.
Pain 2011;152(7):1443-4.
2011: Jenny Donovan; David Grundy
The differential effect of CB1 receptors on the discharge of afferent and efferent fibres supplying the rat jejunum.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011;23(6):567-e209.
2011: Wen Jiang; Ian J Adam; Panagiota Kitsanta; James Tiernan; Chris Hill; Andrew J Shorthouse; David Grundy
'First-in-man': characterising the mechanosensitivity of human colonic afferents.
Gut 2011;60(2):281-2.
2010: D Krueger; M Foerster; K Mueller; Friedrich J Zeller; J Slotta-Huspenina; J Donovan; David Grundy; Michael Schemann
Signaling mechanisms involved in the intestinal pro-secretory actions of hydrogen sulfide.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2010;22(11):1224-31, e319-20.
2010: Donna M Daly; Russell Chess-Williams; Christopher Chapple; David Grundy
The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity.
European urology 2010;58(1):22-8; discussion 31-2.
2010: Christopher Keating; Vicente Martinez; Lorna Ewart; Stephen Gibbons; Luke Grundy; Jean-Pierre Valentin; David Grundy
The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.
Toxicology and applied pharmacology 2010;245(3):299-309.
2009: Chuan-Yong Liu; Mario H Mueller; G Rogler; David Grundy; Martin E Kreis
Differential afferent sensitivity to mucosal lipopolysaccharide from Salmonella typhimurium and Escherichia coli in the rat jejunum.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2009;21(12):1335-e129.
2009: Mario H Mueller; Bing Xue; Jörg Glatzle; Jutta Hahn; David Grundy; Martin E Kreis
Extrinsic afferent nerve sensitivity and enteric neurotransmission in murine jejunum in vitro.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(4):G655-62.
2009: M J Beyak; David Bulmer; D Sellers; David Grundy
Impairment of rectal afferent mechanosensitivity in experimental diabetes in the rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2009;21(6):678-81.
2008: David Grundy
Ainsley Iggo's early recordings from C fibre vagal afferents supplying the gut.
Experimental physiology 2008;93(11):1170-3.
2008: Christopher Keating; Michael Beyak; Stephen Foley; Gulzar Singh; Charles Marsden; Robin Spiller; David Grundy
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism.
The Journal of physiology 2008;586(Pt 18):4517-30.
2008: David Grundy
5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.
European review for medical and pharmacological sciences 2008;12 Suppl 1():63-7.
2008: Mario H Mueller; Jörg Glatzle; Dimitrios Kampitoglou; Michael S Kasparek; David Grundy; Martin E Kreis
Differential sensitization of afferent neuronal pathways during postoperative ileus in the mouse jejunum.
Annals of surgery 2008;247(5):791-802.
2008: CE Booth; J Shaw; Gareth Hicks; Anthony J Kirkup; Wendy J Winchester; David Grundy
Influence of the pattern of jejunal distension on mesenteric afferent sensitivity in the anaesthetized rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2008;20(2):149-58.
2007: Donna Daly; Weifang Rong; R Chess-Williams; Christopher Chapple; David Grundy
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.
The Journal of physiology 2007;583(Pt 2):663-74.
2007: Kirk Hillsley; C McCaul; Jeroen Aerssens; Pieter J Peeters; H Gijsen; Dieder Moechars; Bernard Coulie; David Grundy; Ronald H Stead
Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2007;19(9):769-77.
2007: AM Brunsden; S J H Brookes; K D Bardhan; David Grundy
Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(2):G422-8.
2007: David Grundy; P McLean; Ronald H Stead
Impact of 5-HT3 receptor blockade on colonic haemodynamic responses to ischaemia and reperfusion in the rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2007;19(7):607-16.
2007: Weifang Rong; Wendy J Winchester; David Grundy
Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.
The Journal of physiology 2007;581(Pt 2):779-86.
2007: C Y Liu; Mario H Mueller; David Grundy; Martin E Kreis
Vagal modulation of intestinal afferent sensitivity to systemic LPS in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(5):G1213-20.
2007: Jeroen Aerssens; Kirk Hillsley; Pieter J Peeters; Ronald de Hoogt; Andrzej Stanisz; Jia-Hui Lin; Ilse Van den Wyngaert; Hinrich Göhlmann; David Grundy; Ronald H Stead; Bernard Coulie
Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice.
Gastroenterology 2007;132(4):1375-87.
2007: David Grundy; Michael Schemann
Enteric nervous system.
Current opinion in gastroenterology 2007;23(2):121-6.
2006: Kirk Hillsley; Jia-Hui Lin; Andrzej Stanisz; David Grundy; Jeroen Aerssens; Pieter J Peeters; Dieder Moechars; Bernard Coulie; Ronald H Stead
Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.
The Journal of physiology 2006;576(Pt 1):257-67.
2006: David Grundy
Serotonin and sensory signalling from the gastrointestinal lumen.
The Journal of physiology 2006;575(Pt 1):1-2.
2006: David Grundy
Signalling the state of the digestive tract.
Autonomic neuroscience : basic & clinical 2006;125(1-2):76-80.
2006: David Grundy; Elie D Al-Chaer; Qasim Aziz; Stephen Collins; Meiyun Ke; Yvette Taché; Jackie D Wood
Fundamentals of neurogastroenterology: basic science.
Gastroenterology 2006;130(5):1391-411.
2006: David Grundy; Michael Schemann
Enteric nervous system.
Current opinion in gastroenterology 2006;22(2):102-10.
2006: Pieter J Peeters; Jeroen Aerssens; Ronald de Hoogt; Andrzej Stanisz; Hinrich Göhlmann; Kirk Hillsley; Ann Meulemans; David Grundy; Ronald H Stead; Bernard Coulie
Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity.
Physiological genomics 2006;24(3):252-63.
2005: David Grundy
Sensory signals from the gastrointestinal tract.
Journal of pediatric gastroenterology and nutrition 2005;41 Suppl 1():S7-9.
2005: B Wang; Jörg Glatzle; Mario H Mueller; Martin E Kreis; P Enck; David Grundy
Lipopolysaccharide-induced changes in mesenteric afferent sensitivity of rat jejunum in vitro: role of prostaglandins.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(2):G254-60.
2005: David Grundy; Michael Schemann
Enteric nervous system.
Current opinion in gastroenterology 2005;21(2):176-82.
2005: David Bulmer; Wen Jiang; Gareth Hicks; John B Davis; Wendy J Winchester; David Grundy
Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2005;17(1):102-11.
2005: C-Y Liu; Wen Jiang; Mario H Müller; David Grundy; Martin E Kreis
Sensitization of mesenteric afferents to chemical and mechanical stimuli following systemic bacterial lipopolysaccharide.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2005;17(1):89-101.
2004: C-Y Liu; Mario H Müller; Jörg Glatzle; Dieter Weiser; Olaf Kelber; Paul Enck; David Grundy; Martin E Kreis
The herbal preparation STW 5 (Iberogast) desensitizes intestinal afferents in the rat small intestine.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2004;16(6):759-64.
2004: Weifang Rong; Kirk Hillsley; John B Davis; Gareth Hicks; Wendy J Winchester; David Grundy
Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.
The Journal of physiology 2004;560(Pt 3):867-81.
2004: David Grundy; CE Booth; Wendy J Winchester; Gareth Hicks
Peripheral opiate action on afferent fibres supplying the rat intestine.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2004;16 Suppl 2():29-37.
2004: David Grundy
What activates visceral afferents?
Gut 2004;53 Suppl 2():ii5-8.
2003: Anthony J Kirkup; Wen Jiang; Nigel W Bunnett; David Grundy
Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats.
The Journal of physiology 2003;552(Pt 2):589-601.
2003: Martin E Kreis; Mario H Mueller; D Reber; Jörg Glatzle; Paul Enck; David Grundy
Stress-induced attenuation of brain stem activation following intestinal anaphylaxis in the rat.
Neuroscience letters 2003;345(3):187-91.
2002: AM Brunsden; S Jacob; K D Bardhan; David Grundy
Mesenteric afferent nerves are sensitive to vascular perfusion in a novel preparation of rat ileum in vitro.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(3):G656-65.
2002: Martin E Kreis; Wen Jiang; Anthony J Kirkup; David Grundy
Cosensitivity of vagal mucosal afferents to histamine and 5-HT in the rat jejunum.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(3):G612-7.
2002: David Grundy
Neuroanatomy of visceral nociception: vagal and splanchnic afferent.
Gut 2002;51 Suppl 1():i2-5.
2002: Faiza Abdu; Gareth Hicks; Grant Hennig; Jeremy P Allen; David Grundy
Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(4):G624-33.
2001: S Lal; Anthony J Kirkup; AM Brunsden; David G Thompson; David Grundy
Vagal afferent responses to fatty acids of different chain length in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G907-15.
2001: CE Booth; Anthony J Kirkup; Gareth Hicks; Patrick P A Humphrey; David Grundy
Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat.
Gastroenterology 2001;121(2):358-69.
2001: Anthony J Kirkup; AM Brunsden; David Grundy
Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G787-94.
2000: C Eastwood; David Grundy
Opioid-receptor-mediated excitation of rat mesenteric afferent fibres supplying the rat jejunum.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2000;12(6):517-22.
2000: W Haupt; Wen Jiang; Martin E Kreis; David Grundy
Prostaglandin EP receptor subtypes have distinctive effects on jejunal afferent sensitivity in the rat.
Gastroenterology 2000;119(6):1580-9.
2000: David Grundy
The intestinal mucosa as a target and trigger for enteric reflexes.
Gut 2000;47 Suppl 4():iv44-5; discussion iv52.
2000: Wen Jiang; Martin E Kreis; C Eastwood; Anthony J Kirkup; Patrick P A Humphrey; David Grundy
5-HT(3) and histamine H(1) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats.
Gastroenterology 2000;119(5):1267-75.
2000: Martin E Kreis; M Müller; Tilman T Zittel; Jörg Glatzle; David Grundy
Mediators of neuronal activation in the rat brainstem following intestinal anaphylaxis.
Neuroscience letters 2000;289(1):45-8.
2000: David Grundy; Michael Schemann; J Wood
A tale of two brains, one little and one big.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2000;12(2):105-11.
2000: Wen Jiang; David Grundy
Modulation of gastrointestinal afferent sensitivity by a novel substituted benzamide (ecabapide).
Journal of the autonomic nervous system 2000;78(2-3):99-108.
2000: Kirk Hillsley; C Eeckhout; David Grundy
Cilansetron acts at its site of absorption to antagonize the sensitivity of mesenteric afferent fibres to 5-hydroxytryptamine in the rat jejunum.
Neuroscience letters 2000;278(3):137-40.
1999: AM Brunsden; David Grundy
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
The Journal of physiology 1999;521 Pt 2():517-27.
1999: Anthony J Kirkup; CE Booth; I P Chessell; Patrick P A Humphrey; David Grundy
Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat.
The Journal of physiology 1999;520 Pt 2():551-63.
1999: Kirk Hillsley; David Grundy
Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat.
Journal of the autonomic nervous system 1999;76(2-3):93-8.
1999: K A Maubach; David Grundy
The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro.
The Journal of physiology 1999;515 ( Pt 1)():277-85.
1998: David Grundy; Kirk Hillsley; Anthony J Kirkup; W Richards
Mesenteric afferent sensitivity to cholecystokinin and 5-hydroxytryptamine.
DTW. Deutsche tierärztliche Wochenschrift 1998;105(12):466-8.
1998: Anthony J Kirkup; C Eastwood; David Grundy; I P Chessell; Patrick P A Humphrey
Characterization of adenosine receptors evoking excitation of mesenteric afferents in the rat.
British journal of pharmacology 1998;125(6):1352-60.
1998: Kirk Hillsley; David Grundy
Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents.
Neuroscience letters 1998;255(2):63-6.
1998: C Eastwood; K Maubach; Anthony J Kirkup; David Grundy
The role of endogenous cholecystokinin in the sensory transduction of luminal nutrient signals in the rat jejunum.
Neuroscience letters 1998;254(3):145-8.
1998: Martin E Kreis; W Haupt; Anthony J Kirkup; David Grundy
Histamine sensitivity of mesenteric afferent nerves in the rat jejunum.
The American journal of physiology 1998;275(4 Pt 1):G675-80.
1998: Kirk Hillsley; David Grundy
Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum.
The Journal of physiology 1998;509 ( Pt 3)():717-27.
1998: Kirk Hillsley; Anthony J Kirkup; David Grundy
Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum.
The Journal of physiology 1998;506 ( Pt 2)():551-61.
1996: W Richards; Kirk Hillsley; C Eastwood; David Grundy
Sensitivity of vagal mucosal afferents to cholecystokinin and its role in afferent signal transduction in the rat.
The Journal of physiology 1996;497 ( Pt 2)():473-81.
1995: David Grundy; M Schemann
[Vagovagal regulation of the gastrointestinal tract: from signal conduction to performance response].
Fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk 1995;81(11):104-11.
1995: David Grundy; V Bagaev; Kirk Hillsley
Inhibition of gastric mechanoreceptor discharge by cholecystokinin in the rat.
The American journal of physiology 1995;268(2 Pt 1):G355-60.
1995: K Reid; David Grundy; M I Khan; NW Read
Gastric emptying and the symptoms of vection-induced nausea.
European journal of gastroenterology & hepatology 1995;7(2):103-8.
1994: David Grundy; L A Blackshaw; Kirk Hillsley
Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity.
Digestive diseases and sciences 1994;39(12 Suppl):44S-47S.
1994: David Grundy
The afferent side of the story: the role of sensation and perception in gut dysfunction.
Irish journal of medical science 1994;163(12):562-4.
1993: L A Blackshaw; David Grundy
Effects of 5-hydroxytryptamine (5-HT) on the discharge of vagal mechanoreceptors and motility in the upper gastrointestinal tract of the ferret.
Journal of the autonomic nervous system 1993;45(1):51-9.
1993: L A Blackshaw; David Grundy
Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret.
Journal of the autonomic nervous system 1993;45(1):41-50.
1993: David Grundy; M K Gharib-Naseri; D Hutson
Plasticity in the gastric inhibitory innervation after immunization against VIP and vagotomy in the ferret.
The American journal of physiology 1993;265(3 Pt 1):G432-9.
1993: David Grundy; M K Gharib-Naseri; D Hutson
Role of nitric oxide and vasoactive intestinal polypeptide in vagally mediated relaxation of the gastric corpus in the anaesthetized ferret.
Journal of the autonomic nervous system 1993;43(3):241-6.
1993: David Grundy
Mechanoreceptors in the gastrointestinal tract.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 1993;29(2):37-46.
1992: David Grundy; M K Gharib-Naseri; D Hutson
Effect of immunisation against vasoactive intestinal polypeptide on gastric corpus tone and motility in the ferret.
Gut 1992;33(11):1473-6.
1992: Kirk Hillsley; M Schemann; David Grundy
Alpha-adrenoreceptor modulation of neurally evoked circular muscle responses of the guinea pig stomach.
Journal of the autonomic nervous system 1992;40(1):57-62.
1991: L A Blackshaw; David Grundy
Locally and reflexly mediated effects of cholecystokinin-octapeptide on the ferret stomach.
Journal of the autonomic nervous system 1991;36(2):129-37.
1991: M K Naseri; D Hutson; David Grundy
Vagal influences on gastric acid secretion in response to gastric distension in the ferret.
Journal of the autonomic nervous system 1991;36(1):25-31.
1991: David Grundy; P A Hansson
New non-invasive techniques for crew health monitoring in space.
Acta astronautica 1991;23():321-5.
1990: L A Blackshaw; David Grundy
Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre.
Journal of the autonomic nervous system 1990;31(3):191-201.
1990: L Rudge; David Grundy; D Hutson; T Scratcherd; D Kerrigan
Reflex co-ordination of corporal and antral contractions in the conscious dog.
Experimental physiology 1990;75(6):801-9.
1990: David Grundy
The effect of surgical anaesthesia on antral motility in the ferret.
Experimental physiology 1990;75(5):701-8.
1989: David Grundy; D Hutson; L J Rudge; T Scratcherd
Pre-pyloric mechanisms regulating gastric motor function in the conscious dog.
Quarterly journal of experimental physiology (Cambridge, England) 1989;74(6):857-65.
1989: David Grundy; T Scratcherd
Food for thought--nutritional problems in space.
Journal of the British Interplanetary Society 1989;42(7):374-7.
1989: T Scratcherd; David Grundy
Calcium metabolism and the osteopenia of space flight.
Journal of the British Interplanetary Society 1989;42(7):371-3.
1989: T Scratcherd; David Grundy
Physiological problems for man in space.
Journal of the British Interplanetary Society 1989;42(7):357-9.
1989: David Grundy; T Scratcherd
Space: a testbed for basic biomedical sciences.
Journal of the British Interplanetary Society 1989;42(7):349-51.
1989: L A Blackshaw; David Grundy
Responses of vagal efferent fibres to stimulation of gastric mechano- and chemoreceptors in the anaesthetized ferret.
Journal of the autonomic nervous system 1989;27(1):39-45.
1988: L A Blackshaw; David Grundy
Reflex responses of vagal efferent fibres influenced by gastrointestinal mechanoreceptors to electrical afferent stimulation in the anaesthetized ferret.
Quarterly journal of experimental physiology (Cambridge, England) 1988;73(6):1001-4.
1988: WM Sun; Lesley A Houghton; NW Read; David Grundy; Alan G Johnson
Effect of meal temperature on gastric emptying of liquids in man.
Gut 1988;29(3):302-5.
1987: J S Bull; David Grundy; T Scratcherd
Disruption of the jejunal migrating motor complex by gastric distension and feeding in the dog.
The Journal of physiology 1987;394():381-92.
1986: David Grundy; D Hutson; T Scratcherd
A permissive role for the vagus nerves in the genesis of antro-antral reflexes in the anaesthetized ferret.
The Journal of physiology 1986;381():377-84.
1985: J S Bull; David Grundy; T Scratcherd
The effect of intraluminal tryptophan and phenylalanine on small intestinal motility in the conscious dog.
The Journal of physiology 1985;367():353-62.
1983: David Grundy; D Hutson; T Scratcherd
The response of the pancreas of the anaesthetized cat to secretin before, during and after reversible vagal blockade.
The Journal of physiology 1983;342():517-26.