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Olle Heby

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Chemicals & Drugs

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Publications

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Lyn-Marie Birkholtz; Abraham I Louw; Jandeli Niemand; Lo Persson; Marni Williams; Olle Heby
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.
Olle Heby; Lo Persson; M Rentala
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Veronica T Dufe; Daniel Ingner; Olle Heby; Alex R Khomutov; Lo Persson; Salam Al-Karadaghi
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.

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All Publications

2011: Lyn-Marie Birkholtz; Abraham I Louw; Jandeli Niemand; Lo Persson; Marni Williams; Olle Heby
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities.
The Biochemical journal 2011;438(2):229-44.
2007: Olle Heby; Lo Persson; M Rentala
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Amino acids 2007;33(2):359-66.
2007: Veronica T Dufe; Daniel Ingner; Olle Heby; Alex R Khomutov; Lo Persson; Salam Al-Karadaghi
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
The Biochemical journal 2007;405(2):261-8.
2007: Sigrid C Roberts; Yuqui Jiang; Judith E Gasteier; Benjamin Frydman; Laurence J Marton; Olle Heby; Buddy Ullman
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.
Antimicrobial agents and chemotherapy 2007;51(2):438-45.
2007: Sushma Singh; Angana Mukherjee; Alex R Khomutov; Lo Persson; Olle Heby; Mitali Chatterjee; Madhubala rentala
Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.
Antimicrobial agents and chemotherapy 2007;51(2):528-34.
2004: Sigrid C Roberts; Michael J Tancer; Michelle R Polinsky; K Michael Gibson; Olle Heby; Buddy Ullman
Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants.
The Journal of biological chemistry 2004;279(22):23668-78.
2003: Olle Heby; Sigrid C Roberts; Buddy Ullman
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.
Biochemical Society transactions 2003;31(2):415-9.
2002: Sigrid C Roberts; Jerry Scott; Judith E Gasteier; Yuqui Jiang; Benjamin Brooks; Armando Jardim; Nicola S Carter; Olle Heby; Buddy Ullman
S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.
The Journal of biological chemistry 2002;277(8):5902-9.
2001: Sigrid C Roberts; Yuqui Jiang; Armando Jardim; Nicola S Carter; Olle Heby; Buddy Ullman
Genetic analysis of spermidine synthase from Leishmania donovani.
Molecular and biochemical parasitology 2001;115(2):217-26.
2001: Amel Gritli-Linde; J Nilsson; Mohammad Bohlooly-Y; Olle Heby; Anders Linde
Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;220(3):259-75.
2000: J Nilsson; Amel Gritli-Linde; Olle Heby
Skin fibroblasts from spermine synthase-deficient hemizygous gyro male (Gy/Y) mice overproduce spermidine and exhibit increased resistance to oxidative stress but decreased resistance to UV irradiation.
The Biochemical journal 2000;352 Pt 2():381-7.
2000: J Nilsson; B Grahn; Olle Heby
Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression.
The Biochemical journal 2000;346 Pt 3():699-704.
1999: L Frostesjö; Olle Heby
Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells.
Journal of cellular biochemistry 1999;76(1):143-52.
1999: K Persson; Olle Heby; F G Berger
The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(8):784-8.
1998: K Persson; Lena Aslund; B Grahn; J Hanke; Olle Heby
Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme.
The Biochemical journal 1998;333 ( Pt 3)():527-37.
1997: Jan Bjersing; Ann-Christin Brorsson; Olle Heby
Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.
Journal of cellular biochemistry 1997;67(3):378-85.
1997: L Frostesjö; I Holm; B Grahn; A W Page; T H Bestor; Olle Heby
Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.
The Journal of biological chemistry 1997;272(7):4359-66.
1995: U Rosander; I Holm; B Grahn; H Løvtrup-Rein; M O Mattsson; Olle Heby
Down-regulation of ornithine decarboxylase by an increased degradation of the enzyme during gastrulation of Xenopus laevis.
Biochimica et biophysica acta 1995;1264(1):121-8.
1995: Olle Heby
DNA methylation and polyamines in embryonic development and cancer.
The International journal of developmental biology 1995;39(5):737-57.
1995: U M Wallon; L Persson; Olle Heby
Regulation of ornithine decarboxylase during cell growth. Changes in the stability and translatability of the mRNA, and in the turnover of the protein.
Molecular and cellular biochemistry 1995;146(1):39-44.
1995: K Persson; I Holm; Olle Heby
Cloning and sequencing of an intronless mouse S-adenosylmethionine decarboxylase gene coding for a functional enzyme strongly expressed in the liver.
The Journal of biological chemistry 1995;270(10):5642-8.
1993: A Ask; L Persson; A Rehnholm; L Frostesjö; I Holm; Olle Heby
Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit.
Cancer research 1993;53(21):5262-8.
1993: L Stjernborg; Olle Heby; P Mamont; L Persson
Polyamine-mediated regulation of S-adenosylmethionine decarboxylase expression in mammalian cells. Studies using 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, a suicide inhibitor of the enzyme.
European journal of biochemistry / FEBS 1993;214(3):671-6.
1993: A Ask; L Persson; N Seiler; Olle Heby
Antileukemic effects of non-metabolizable derivatives of spermidine and spermine.
Cancer letters 1993;69(1):33-8.
1992: A Ask; L Persson; Olle Heby
Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet.
Cancer letters 1992;66(1):29-34.
1991: L Stjernborg; Olle Heby; I Holm; L Persson
On the translational control of ornithine decarboxylase expression by polyamines.
Biochimica et biophysica acta 1991;1090(2):188-94.
1990: U M Wallon; L Persson; Olle Heby
Superinduction of ornithine decarboxylase (ODC) by actinomycin D is due to stimulation of ODC mRNA translation.
FEBS letters 1990;268(1):161-4.
1990: S M Oredsson; B Nicander; Olle Heby
Implications for a reduced DNA-elongation rate in polyamine-depleted cells.
European journal of biochemistry / FEBS 1990;190(3):483-9.
1990: M Wallon; I Holm; L Thorsson; S M Oredsson; Olle Heby
Residual proliferative capacity in F9 teratocarcinoma stem cell cultures treated with alpha-difluoromethylornithine, an inducer of parietal endoderm differentiation.
Cancer letters 1990;50(2):103-7.
1990: R Autelli; I Holm; Olle Heby; L Persson
Feedback regulation of ornithine decarboxylase expression. Studies using a polysomal run-off system.
FEBS letters 1990;260(1):39-41.
1989: I Holm; L Persson; A E Pegg; Olle Heby
Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells.
The Biochemical journal 1989;261(1):205-10.
1989: L Persson; L Stjernborg; I Holm; Olle Heby
Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA.
Biochemical and biophysical research communications 1989;160(3):1196-202.
1989: P Aman; S M Oredsson; Olle Heby
Inhibition of polyamine synthesis in human B lymphocytes during primary infection with Epstein-Barr virus (EBV) blocks cellular DNA synthesis but not the expression of EBV-encoded nuclear antigens (EBNA).
Biochemical and biophysical research communications 1989;159(3):945-52.
1989: I Holm; L Persson; L Stjernborg; L Thorsson; Olle Heby
Feedback control of ornithine decarboxylase expression by polyamines. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles and of translation of this mRNA in vitro.
The Biochemical journal 1989;258(2):343-50.
1988: I Holm; L Persson; Olle Heby; N Seiler
Feedback regulation of polyamine synthesis in Ehrlich ascites tumor cells. Analysis using nonmetabolizable derivatives of putrescine and spermine.
Biochimica et biophysica acta 1988;972(3):239-48.
1988: L Persson; I Holm; A Ask; Olle Heby
Curative effect of DL-2-difluoromethylornithine on mice bearing mutant L1210 leukemia cells deficient in polyamine uptake.
Cancer research 1988;48(17):4807-11.
1988: S Anehus; S M Oredsson; Olle Heby
Ehrlich ascites tumour cells become refractory to alpha-difluoromethylornithine at a certain stage of growth.
Cell biochemistry and function 1988;6(2):115-21.
1988: L Persson; I Holm; Olle Heby
Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene.
The Journal of biological chemistry 1988;263(7):3528-33.
1988: Olle Heby; L Persson; S S Smith
Polyamines, DNA methylation and cell differentiation.
Advances in experimental medicine and biology 1988;250():291-9.
1988: L Persson; I Holm; L Stjernborg; Olle Heby
Regulation of polyamine synthesis in mammalian cells.
Advances in experimental medicine and biology 1988;250():261-71.
1987: B Löwkvist; S M Oredsson; I Holm; H Emanuelsson; Olle Heby
Inhibition of polyamine synthesis reduces the growth rate and delays the expression of differentiated phenotypes in primary cultures of embryonic mesoderm from chick.
Cell and tissue research 1987;249(1):151-60.
1987: B Löwkvist; H Emanuelsson; L Persson; F Sundler; A Lundquist; Olle Heby
Localization of ornithine decarboxylase in the chick embryo during organogenesis.
Cell and tissue research 1987;247(1):75-84.
1986: B Löwkvist; H Emanuelsson; E Egyházi; J Sjöberg; E Långström; Olle Heby
Transcriptional inhibition in early chick embryos as a result of polyamine depletion.
Developmental biology 1986;116(2):291-301.
1986: S Anehus; T Yngner; L Hafström; Olle Heby
Increased urinary polyamine excretion during liver regeneration.
Biochemical medicine and metabolic biology 1986;35(3):322-6.
1986: S M Oredsson; M Kanje; P S Mamont; J Wagner; Olle Heby
Polyamine depletion increases cellular ribonucleotide levels.
Molecular and cellular biochemistry 1986;70(1):89-96.
1986: A Ask; L Persson; S M Oredsson; Olle Heby
Synergistic antileukemic effect of two polyamine synthesis inhibitors. Host survival and cell-cycle kinetic analysis.
International journal of cancer. Journal international du cancer 1986;37(3):465-70.
1985: M Linden; S Anehus; E Långström; Bo Baldetorp; Olle Heby
Cell cycle phase-dependent induction of ornithine decarboxylase-antizyme.
Journal of cellular physiology 1985;125(2):273-6.
1985: S M Oredsson; M Billgren; Olle Heby
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
European journal of cell biology 1985;38(2):335-43.
1985: L Persson; S M Oredsson; S Anehus; Olle Heby
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: implications for translational regulation.
Biochemical and biophysical research communications 1985;131(1):239-45.
1985: B Löwkvist; H Emanuelsson; Olle Heby
Changes in polyamine synthesis and concentrations during chick embryo development.
The Journal of experimental zoology 1985;234(3):375-82.
1985: M Linden; S M Oredsson; S Anehus; Olle Heby
Inhibition of ornithine decarboxylase activity and cell growth by diamines: a comparison between the effects of two homologs, 1,3-diaminopropane and 1,4-diaminobutane (putrescine).
Journal of cellular biochemistry 1985;29(2):105-13.
1984: S Anehus; H Emanuelsson; L Persson; F Sundler; I E Scheffler; Olle Heby
Localization of ornithine decarboxylase in mutant CHO cells that overproduce the enzyme. Differences between the intracellular distribution of monospecific ornithine decarboxylase antibodies and radiolabeled alpha-difluoromethylornithine.
European journal of cell biology 1984;35(2):264-72.
1984: S M Oredsson; S Anehus; Olle Heby
Reversal of the growth inhibitory effect of alpha-difluoromethylornithine by putrescine but not by other divalent cations.
Molecular and cellular biochemistry 1984;64(2):163-72.
1984: S Anehus; P Pohjanpelto; Bo Baldetorp; E Långström; Olle Heby
Polyamine starvation prolongs the S and G2 phases of polyamine-dependent (arginase-deficient) CHO cells.
Molecular and cellular biology 1984;4(5):915-22.
1984: Olle Heby; S M Oredsson; M Kanje
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Advances in enzyme regulation 1984;22():243-64.
1984: S M Oredsson; M Linden; Olle Heby
Increased rate of tumor cell death caused by polyamine synthesis inhibitors.
Virchows Archiv. B, Cell pathology including molecular pathology 1984;47(2):131-8.
1983: H Emanuelsson; Olle Heby
Nuclear ornithine decarboxylase. Electron microscope autoradiographic identification of the active enzyme using alpha-[5-3H]difluoromethylornithine.
European journal of cell biology 1983;30(2):288-94.
1983: S Anehus; T Yngner; C Engelbrecht; L Hafströlm; Olle Heby
Urinary polyamine excretion as related to cell death and cell proliferation induced by carbon tetrachloride intoxication.
Experimental and molecular pathology 1983;38(2):255-63.
1983: A Lundquist; B Löwkvist; M Linden; Olle Heby
Polyamines in early embryonic development: their relationship to nuclear multiplication rate, cell cycle traverse, and nucleolar formation in a dipteran egg.
Developmental biology 1983;95(2):253-9.
1983: B Löwkvist; H Emanuelsson; Olle Heby
Effects of polyamine limitation on nucleolar development and morphology in early chick embryos.
Cell differentiation 1983;12(1):19-26.
1981: S Anehus; A Albinsson; G Andersson; Olle Heby
Urinary polyamine excretion during growth and regression of 1,12-dimethylbenz[a]anthracene-induced rat mammary carcinoma.
Journal of the National Cancer Institute 1981;67(6):1265-8.
1981: S Anehus; G Bengtsson; G Andersson; G Carlsson; L Hafström; T Yngner; Olle Heby
Urinary putrescine and plasma lactate dehydrogenase as markers of experimental adenocarcinoma growth.
European journal of cancer 1981;17(5):511-8.
1980: B Löwkvist; Olle Heby; H Emanuelsson
Essential role of the polyamines in early chick embryo development.
Journal of embryology and experimental morphology 1980;60():83-92.
1980: S Oredsson; S Anehus; Olle Heby
Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.
Biochemical and biophysical research communications 1980;94(1):151-8.
1980: M Linden; S Oredsson; Olle Heby
Cytocidal effect of alpha-methylornithine, a competitive inhibitor of ornithine decarboxylase, on ehrlich ascites tumor cells in vivo.
Cancer letters 1980;9(3):207-12.
1980: B Löwkvist; Olle Heby; H Emanuelsson
DL-alpha Difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, blocks chick embryo development at gastrulation.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1980;34(6):459-60.
1980: S Oredsson; S Anehus; Olle Heby
Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1980;34(6):457-8.