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Alan Cowman

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Chemicals & Drugs

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Justin A Boddey; Teresa G Carvalho; Anthony N Hodder; Sash Lopaticki; Danushka Marapana; Thomas Nebl; Tobias J Sargeant; Brad E Sleebs; Alan F Cowman
Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.
David T Riglar; Kelly L Rogers; Lynne Turnbull; Cynthia B Whitchurch; Jake Baum; Hayley E Bullen; Sarah C Charnaud; Brendan S Crabb; Paul R Gilson; Eric Hanssen; Jude M Przyborski; Alan F Cowman
Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.
Anthony N Hodder; Clara S Lin; Brian J Smith; Alessandro D Uboldi; Oliver B Clarke; Peter E Czabotar; Julie Healer; Alan F Cowman
Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.

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All Publications

2013: Justin A Boddey; Teresa G Carvalho; Anthony N Hodder; Sash Lopaticki; Danushka Marapana; Thomas Nebl; Tobias J Sargeant; Brad E Sleebs; Alan F Cowman
Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.
Traffic (Copenhagen, Denmark) 2013;14(5):532-50.
2013: David T Riglar; Kelly L Rogers; Lynne Turnbull; Cynthia B Whitchurch; Jake Baum; Hayley E Bullen; Sarah C Charnaud; Brendan S Crabb; Paul R Gilson; Eric Hanssen; Jude M Przyborski; Alan F Cowman
Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes.
Nature communications 2013;4():1415.
2012: Anthony N Hodder; Clara S Lin; Brian J Smith; Alessandro D Uboldi; Oliver B Clarke; Peter E Czabotar; Julie Healer; Alan F Cowman
Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.
The Journal of biological chemistry 2012;287(39):32922-39.
2012: Alan F Cowman; Drew Berry; Jake Baum
The cellular and molecular basis for malaria parasite invasion of the human red blood cell.
The Journal of cell biology 2012;198(6):961-71.
2012: Hayley E Bullen; Sarah C Charnaud; Alan F Cowman; Brendan S Crabb; Tania F de Koning-Ward; Chaitali Dekiwadia; Ming Kalanon; Niwat Kangwanrangsan; Stuart A Ralph; David T Riglar; Motomi Torii; Takafumi Tsuboi; Jacob Baum; Paul R Gilson
Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX).
The Journal of biological chemistry 2012;287(11):7871-84.
2012: Hirokazu Sakamoto; jetsumon prachumsri; Satoru Takeo; Alan F Cowman; Alexander G Maier; Takafumi Tsuboi
Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoite invasion into human erythrocytes.
Vaccine 2012;30(11):1972-80.
2012: Danika L Hill; Danny W Wilson; Amandine B Carmagnac; Alan F Cowman; Emily M Eriksson; Diana Hansen; Louis Schofield
Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites.
PloS one 2012;7(12):e51692.
2012: Linda Reiling; Jack S Richards; Peter Siba; Janine Stubbs; Livingstone Tavul; Wai-Hong Tham; Danny W Wilson; Alyssa E Barry; Watcharee Chokejindachai; Alan F Cowman; Brendan S Crabb; John Donelson; Freya J I Fowkes; Christine Langer; Pascal Michon; Ivo Mueller; James G Beeson
The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.
PloS one 2012;7(9):e45253.
2012: Tana Taechalertpaisarn; Jenny Thompson; Danny W Wilson; Gavin J Wright; S Josefin Bartholdson; Leyla Y Bustamante; Alan F Cowman; Cecile Crosnier; Paul R Gilson; Anthony N Hodder; Julian C Rayner; Paul R Sanders; Brendan S Crabb
Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41.
PloS one 2012;7(7):e41937.
2012: Florian Ehlgen; James S Pham; Alan F Cowman; Tania de Koning-Ward; Stuart A Ralph
Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT).
PloS one 2012;7(6):e38781.
2012: Fiona Angrisano; Clare H Bradin; Alan F Cowman; Chaitali Dekiwadia; Michael J Delves; Peter W Gunning; Danushka S Marapana; Geoffrey I McFadden; Vanessa Mollard; Maya A Olshina; Stuart A Ralph; David T Riglar; Robert E Sinden; Angelika Sturm; Christopher J Tonkin; Lynne Turnbull; Jennifer C Volz; Cynthia B Whitchurch; Wilson Wong; Elizabeth S Zuccala; Jake Baum
Spatial localisation of actin filaments across developmental stages of the malaria parasite.
PloS one 2012;7(2):e32188.
2011: Thangavelu U Arumugam; James G Beeson; Alan F Cowman; Brendan S Crabb; Julie Healer; Carole A Long; Kazutoyo Miura; Hitoshi Otsuki; jetsumon prachumsri; Satoru Takeo; Jennifer Thompson; Amporn Thonkukiatkul; Motomi Torii; Danny W Wilson; Tsutomu Yamasaki; Hong Zhou; Takafumi Tsuboi
Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen.
Infection and immunity 2011;79(11):4523-32.
2011: Thomas Nebl; Judith Helena Prieto; Brian J Smith; Alan F Cowman; Eugene Kapp; Melanie J Williams; John R Yates; Christopher J Tonkin
Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex.
PLoS pathogens 2011;7(9):e1002222.
2011: Lin Chen; Jake Baum; Chaitali Dekiwadia; Sash Lopaticki; Matthew T O'Neill; Stuart A Ralph; Dave Richard; David T Riglar; Wai-Hong Tham; Alex D Uboldi; Alan F Cowman
An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
PLoS pathogens 2011;7(9):e1002199.
2011: Wai-Hong Tham; John P Atkinson; Paul N Barlow; Mara Guariento; Richard E Hauhart; Sash Lopaticki; Christoph Q Schmidt; Patience B Tetteh-Quarcoo; Alan F Cowman
Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes.
Blood 2011;118(7):1923-33.
2011: mikolajczak sebastian; John B Sacci; Kelly VanBuskirk; Urszula Krzych; Nelly Camargo; Jun Cao; Alan F Cowman; Patricia de la Vega; Marcelo Jacobs-Lorena; Stefan Kappe
Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites.
Cellular microbiology 2011;13(8):1250-60.
2011: Jake Baum; Alan F Cowman
Biochemistry. Revealing a parasite's invasive trick.
Science (New York, N.Y.) 2011;333(6041):410-1.
2011: Tony Triglia; Jake Baum; Lin Chen; Chaitali Dekiwadia; Anthony N Hodder; Sash Lopaticki; Stuart A Ralph; David T Riglar; Alan F Cowman
Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
PLoS pathogens 2011;7(6):e1002075.
2011: Sash Lopaticki; Alexander G Maier; Jennifer Thompson; Danny W Wilson; Wai-Hong Tham; Tony Triglia; Alex Gout; Terence P Speed; James G Beeson; Julie Healer; Alan F Cowman
Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites.
Infection and immunity 2011;79(3):1107-17.
2011: Alan F Cowman; Christopher J Tonkin
Microbiology. A tail of division.
Science (New York, N.Y.) 2011;331(6016):409-10.
2011: David T Riglar; Dave Richard; Danny W Wilson; Michelle J Boyle; Chaitali Dekiwadia; Lynne Turnbull; Fiona Angrisano; Danushka S Marapana; Kelly L Rogers; Cynthia B Whitchurch; James G Beeson; Alan F Cowman; Stuart A Ralph; Jake Baum
Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte.
Cell host & microbe 2011;9(1):9-20.
2011: Matthew O'Neill; Thuan Phuong; Julie Healer; Dave Richard; Alan F Cowman
Gene deletion from Plasmodium falciparum using FLP and Cre recombinases: implications for applied site-specific recombination.
International journal for parasitology 2011;41(1):117-23.
2010: Linda Reiling; Jack S Richards; Freya J I Fowkes; Alyssa E Barry; Tony Triglia; Watcharee Chokejindachai; Pascal Michon; Livingstone Tavul; Peter M Siba; Alan F Cowman; Ivo Mueller; James G Beeson
Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):6157-67.
2010: Jack S Richards; Danielle I Stanisic; Freya J I Fowkes; Livingstone Tavul; Elijah Dabod; Jennifer K Thompson; Sanjeev Kumar; Chetan E Chitnis; David Narum; Pascal Michon; Peter M Siba; Alan F Cowman; Ivo Mueller; James G Beeson
Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(8):e50-60.
2010: Wai-Hong Tham; Danny W Wilson; Sash Lopaticki; Christoph Q Schmidt; Patience B Tetteh-Quarcoo; Paul N Barlow; Dave Richard; Jason E Corbin; James G Beeson; Alan F Cowman
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17327-32.
2010: Stefan Kappe; Ashley M Vaughan; Justin A Boddey; Alan F Cowman
That was then but this is now: malaria research in the time of an eradication agenda.
Science (New York, N.Y.) 2010;328(5980):862-6.
2010: Drew C Mackellar; Matthew O'Neill; Ahmed S I Aly; John B Sacci; Alan F Cowman; Stefan Kappe
Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages.
Eukaryotic cell 2010;9(5):784-94.
2010: Justin A Boddey; Anthony N Hodder; Svenja Günther; Paul R Gilson; Heather Patsiouras; Eugene A Kapp; J Andrew Pearce; Tania F de Koning-Ward; Richard J Simpson; Brendan S Crabb; Alan F Cowman
An aspartyl protease directs malaria effector proteins to the host cell.
Nature 2010;463(7281):627-31.
2010: Jennifer Volz; Teresa G Carvalho; Stuart A Ralph; Paul R Gilson; Jenny Thompson; Christopher J Tonkin; Christine Langer; Brendan S Crabb; Alan F Cowman
Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum.
International journal for parasitology 2010;40(1):109-21.
2009: Tony Triglia; Wai-Hong Tham; Anthony Hodder; Alan F Cowman
Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum.
Cellular microbiology 2009;11(11):1671-87.
2009: Christian Flueck; Richard Bartfai; Jennifer Volz; Igor Niederwieser; Adriana M Salcedo-Amaya; Blaise T F Alako; Florian Ehlgen; Stuart A Ralph; Alan F Cowman; Zbynek Bozdech; Hendrik G Stunnenberg; Till S Voss
Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.
PLoS pathogens 2009;5(9):e1000569.
2009: Kelley M VanBuskirk; Matthew O'Neill; Patricia De La Vega; Alexander G Maier; Urszula Krzych; Jack Williams; Megan G Dowler; John B Sacci; Niwat Kangwanrangsan; Takafumi Tsuboi; Norman M Kneteman; DONALD HEPPNER; Brant A Murdock; mikolajczak sebastian; Ahmed S I Aly; Alan F Cowman; Stefan Kappe
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):13004-9.
2009: Tania F de Koning-Ward; Paul R Gilson; Justin A Boddey; Melanie Rug; Brian J Smith; Anthony T Papenfuss; Paul R Sanders; Rachel J Lundie; Alexander G Maier; Alan F Cowman; Brendan S Crabb
A newly discovered protein export machine in malaria parasites.
Nature 2009;459(7249):945-9.
2009: Jake Baum; Anthony T Papenfuss; Gunnar R Mair; Chris J Janse; Dina Vlachou; Andrew P Waters; Alan F Cowman; Brendan S Crabb; Tania F de Koning-Ward
Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites.
Nucleic acids research 2009;37(11):3788-98.
2009: Wai-Hong Tham; Danny W Wilson; Linda Reiling; Lin Chen; James G Beeson; Alan F Cowman
Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes.
Infection and immunity 2009;77(6):2427-35.
2009: Tiffany M DeSimone; Cameron V Jennings; Amy K Bei; Christy Comeaux; Bradley I Coleman; Philippe Refour; Tony Triglia; Janine Stubbs; Alan F Cowman; Manoj T Duraisingh
Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes.
Molecular microbiology 2009;72(3):578-89.
2009: Alexander G Maier; Brian M Cooke; Alan F Cowman; Leann Tilley
Malaria parasite proteins that remodel the host erythrocyte.
Nature reviews. Microbiology 2009;7(5):341-54.
2009: Christopher J Tonkin; Céline K Carret; Manoj T Duraisingh; Till S Voss; Stuart A Ralph; Mirja Hommel; Michael Duffy; Liliana Mancio da Silva; Artur Scherf; Alasdair Ivens; Terence P Speed; James G Beeson; Alan F Cowman
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PLoS biology 2009;7(4):e84.
2009: Alexander G Maier; Jake Baum; Brian Smith; David J Conway; Alan F Cowman
Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum.
Infection and immunity 2009;77(4):1689-99.
2009: Dave Richard; Lev M Kats; Christine Langer; Casilda G Black; Khosse Mitri; Justin A Boddey; Alan F Cowman; Ross Coppel
Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum.
PLoS pathogens 2009;5(3):e1000328.
2009: Justin A Boddey; Robert L Moritz; Richard J Simpson; Alan F Cowman
Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte.
Traffic (Copenhagen, Denmark) 2009;10(3):285-99.
2009: Jake Baum; Lin Chen; Julie Healer; Sash Lopaticki; Michelle Boyle; Tony Triglia; Florian Ehlgen; Stuart A Ralph; James G Beeson; Alan F Cowman
Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum.
International journal for parasitology 2009;39(3):371-80.
2009: Anthony N Hodder; Alexander G Maier; Melanie Rug; Monica Brown; Mirja Hommel; Ivan Pantic; Marina Puig-de-Morales-Marinkovic; Brian Smith; Tony Triglia; James G Beeson; Alan F Cowman
Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum.
Molecular microbiology 2009;71(1):48-65.
2008: Bui Q Phuc; Sonia R Caruana; Alan F Cowman; Beverley-Ann Biggs; Ngo V Thanh; Nong T Tien; Le K Thuan
Prevalence of polymorphisms in DHFR, DHPS, PFMDR1 and PFCRT genes of Plasmodium falciparum isolates in Quang Tri Province, Vietnam.
The Southeast Asian journal of tropical medicine and public health 2008;39(6):959-62.
2008: Alexander G Maier; Melanie Rug; Matthew O'Neill; Monica Brown; Srabasti Chakravorty; Tadge Szestak; Joanne Chesson; Yang Wu; Katie Hughes; Ross Coppel; Chris Newbold; James G Beeson; Alister Craig; Brendan S Crabb; Alan F Cowman
Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes.
Cell 2008;134(1):48-61.
2008: Nicole S Struck; Susann Herrmann; Christine Langer; Andreas Krueger; Bernardo J Foth; Klemens Engelberg; Ana L Cabrera; Silvia Haase; Moritz Treeck; Matthias Marti; Alan F Cowman; Tobias Spielmann; Tim-Wolf Gilberger
Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism.
Journal of cell science 2008;121(Pt 13):2123-9.
2008: Cornelia Spycher; Melanie Rug; Esther Pachlatko; Eric Hanssen; David Ferguson; Alan F Cowman; Leann Tilley; Hans-Peter Beck
The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes.
Molecular microbiology 2008;68(5):1300-14.
2008: Sven B Gould; Wai-Hong Tham; Alan F Cowman; Geoffrey I McFadden; Ross F Waller
Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata.
Molecular biology and evolution 2008;25(6):1219-30.
2008: Christopher J Tonkin; Bernardo J Foth; Stuart A Ralph; Nicole S Struck; Alan F Cowman; Geoffrey I McFadden
Evolution of malaria parasite plastid targeting sequences.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4781-5.
2008: Jake Baum; Christopher J Tonkin; Aditya S Paul; Melanie Rug; Brian J Smith; Sven B Gould; Dave Richard; Thomas D Pollard; Alan F Cowman
A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.
Cell host & microbe 2008;3(3):188-98.
2008: Nicole S Struck; Susann Herrmann; Iris Schmuck-Barkmann; Suzana de Souza Dias; Silvia Haase; Ana L Cabrera; Moritz Treeck; Caroline Bruns; Christine Langer; Alan F Cowman; Matthias Marti; Tobias Spielmann; Tim-Wolf Gilberger
Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum.
Molecular microbiology 2008;67(6):1320-30.
2008: Silvia Haase; Ana Cabrera; Christine Langer; Moritz Treeck; Nicole Struck; Susann Herrmann; Pascal W Jansen; Iris Bruchhaus; Anna Bachmann; Suzana Dias; Alan F Cowman; Hendrik G Stunnenberg; Tobias Spielmann; Tim-Wolf Gilberger
Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum.
Infection and immunity 2008;76(3):879-87.
2008: Kristina E M Persson; Fiona J McCallum; Linda Reiling; Nicole A Lister; Janine Stubbs; Alan F Cowman; Kevin Marsh; James G Beeson
Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies.
The Journal of clinical investigation 2008;118(1):342-51.
2007: Palakodeti V N Dasaradhi; Reshma Korde; Jennifer K Thompson; Charu Tanwar; Tapas Chandra Nag; Virander S Chauhan; Alan F Cowman; Asif Mohmmed; Pawan Malhotra
Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum.
Molecular and biochemical parasitology 2007;156(1):12-23.
2007: Till S Voss; Christopher J Tonkin; Allison J Marty; Jennifer K Thompson; Julie Healer; Brendan S Crabb; Alan F Cowman
Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum.
Molecular microbiology 2007;66(1):139-50.
2007: Marthe C D'Ombrain; Till S Voss; Alexander G Maier; J Andrew Pearce; Diana Hansen; Alan F Cowman; Louis Schofield
Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma.
Cell host & microbe 2007;2(2):130-8.
2007: Akinola Adisa; Sarah Frankland; Melanie Rug; Katherine Jackson; Alexander G Maier; Peter Walsh; Trevor Lithgow; Nectarios Klonis; Paul R Gilson; Alan F Cowman; Leann Tilley
Re-assessing the locations of components of the classical vesicle-mediated trafficking machinery in transfected Plasmodium falciparum.
International journal for parasitology 2007;37(10):1127-41.
2007: Salenna R Elliott; Timothy P Spurck; Joelle M Dodin; Alexander G Maier; Till S Voss; Francisca Yosaatmadja; Paul D Payne; Geoffrey I McFadden; Alan F Cowman; Stephen J Rogerson; Louis Schofield; Graham V Brown
Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1.
Infection and immunity 2007;75(7):3621-32.
2007: Leann Tilley; Geoff McFadden; Alan F Cowman; Nectarios Klonis
Illuminating Plasmodium falciparum-infected red blood cells.
Trends in parasitology 2007;23(6):268-77.
2007: Alexander G Maier; Melanie Rug; Matthew O'Neill; James G Beeson; Matthias Marti; John Reeder; Alan F Cowman
Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface.
Blood 2007;109(3):1289-97.
2006: Alexander G Maier; Joanna A M Braks; Andrew P Waters; Alan F Cowman
Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination.
Molecular and biochemical parasitology 2006;150(1):118-21.
2006: Moritz Treeck; Nicole S Struck; Silvia Haase; Christine Langer; Susann Herrmann; Julie Healer; Alan F Cowman; Tim-Wolf Gilberger
A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum.
The Journal of biological chemistry 2006;281(42):31995-2003.
2006: Allison J Marty; Jennifer K Thompson; Michael Duffy; Till S Voss; Alan F Cowman; Brendan S Crabb
Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation.
Molecular microbiology 2006;62(1):72-83.
2006: Alan F Cowman; Stefan Kappe
Microbiology. Malaria's stealth shuttle.
Science (New York, N.Y.) 2006;313(5791):1245-6.
2006: Jake Baum; Anthony T Papenfuss; Buzz Baum; Terence P Speed; Alan F Cowman
Regulation of apicomplexan actin-based motility.
Nature reviews. Microbiology 2006;4(8):621-8.
2006: Christopher J Tonkin; J Andrew Pearce; Geoffrey I McFadden; Alan F Cowman
Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum.
Current opinion in microbiology 2006;9(4):381-7.
2006: Michael Duffy; Alexander G Maier; Timothy J Byrne; Allison J Marty; Salenna R Elliott; Matthew O'Neill; Paul D Payne; Stephen J Rogerson; Alan F Cowman; Brendan S Crabb; Graham V Brown
VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum.
Molecular and biochemical parasitology 2006;148(2):117-24.
2006: Melanie Rug; Stuart W Prescott; Kate M Fernandez; Brian M Cooke; Alan F Cowman
The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes.
Blood 2006;108(1):370-8.
2006: Cornelia Spycher; Melanie Rug; Nectarios Klonis; David J P Ferguson; Alan F Cowman; Hans-Peter Beck; Leann Tilley
Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes.
Molecular and cellular biology 2006;26(11):4074-85.
2006: Sarah Frankland; Akinola Adisa; Paul Horrocks; Theodore F Taraschi; Timothy Schneider; Salenna R Elliott; Stephen J Rogerson; Ellen Knuepfer; Alan F Cowman; Christopher I Newbold; Leann Tilley
Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.
Eukaryotic cell 2006;5(5):849-60.
2006: Alan F Cowman; Brendan S Crabb
Invasion of red blood cells by malaria parasites.
Cell 2006;124(4):755-66.
2006: Jake Baum; Dave Richard; Julie Healer; Melanie Rug; Zita Krnajski; Tim-Wolf Gilberger; Judith L Green; Anthony A Holder; Alan F Cowman
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.
The Journal of biological chemistry 2006;281(8):5197-208.
2006: Till S Voss; Julie Healer; Allison J Marty; Michael Duffy; Jennifer K Thompson; James G Beeson; John C Reeder; Brendan S Crabb; Alan F Cowman
A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.
Nature 2006;439(7079):1004-8.
2006: Tobias Sargeant; Matthias Marti; Elisabet Caler; Jane M Carlton; Ken Simpson; Terence P Speed; Alan F Cowman
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.
Genome biology 2006;7(2):R12.
2005: Jake Baum; Alexander G Maier; Rob Trygve Good; Ken M Simpson; Alan F Cowman
Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions.
PLoS pathogens 2005;1(4):e37.
2005: Nicole S Struck; Suzana de Souza Dias; Christine Langer; Matthias Marti; J Andrew Pearce; Alan F Cowman; Tim-Wolf Gilberger
Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP.
Journal of cell science 2005;118(Pt 23):5603-13.
2005: Matthias Marti; Jake Baum; Melanie Rug; Leann Tilley; Alan F Cowman
Signal-mediated export of proteins from the malaria parasite to the host erythrocyte.
The Journal of cell biology 2005;171(4):587-92.
2005: Ellen Knuepfer; Melanie Rug; Nectarios Klonis; Leann Tilley; Alan F Cowman
Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.
Molecular microbiology 2005;58(4):1039-53.
2005: Brian M Cooke; Narla Mohandas; Alan F Cowman; Ross Coppel
Cellular adhesive phenomena in apicomplexan parasites of red blood cells.
Veterinary parasitology 2005;132(3-4):273-95.
2005: Janine Stubbs; Ken M Simpson; Tony Triglia; David Plouffe; Christopher J Tonkin; Manoj T Duraisingh; Alexander G Maier; Elizabeth A Winzeler; Alan F Cowman
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.
Science (New York, N.Y.) 2005;309(5739):1384-7.
2005: Ellen Knuepfer; Melanie Rug; Alan F Cowman
Function of the plasmodium export element can be blocked by green fluorescent protein.
Molecular and biochemical parasitology 2005;142(2):258-62.
2005: Giel G van Dooren; Matthias Marti; Christopher J Tonkin; Luciana M Stimmler; Alan F Cowman; Geoffrey I McFadden
Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum.
Molecular microbiology 2005;57(2):405-19.
2005: Alan F Cowman; Brendan S Crabb
Revealing the molecular determinants of gender in malaria parasites.
Cell 2005;121(5):659-60.
2005: Manoj T Duraisingh; Alan F Cowman
Contribution of the pfmdr1 gene to antimalarial drug-resistance.
Acta tropica 2005;94(3):181-90.
2005: Ellen Knuepfer; Melanie Rug; Nectarios Klonis; Leann Tilley; Alan F Cowman
Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes.
Blood 2005;105(10):4078-87.
2005: Jun Fu; Fabián E Sáenz; Michael B Reed; Bharath Balu; Naresh Singh; Peter L Blair; Alan F Cowman; John H Adams
Targeted disruption of maebl in Plasmodium falciparum.
Molecular and biochemical parasitology 2005;141(1):113-7.
2005: Ken M Simpson; Jake Baum; Rob Trygve Good; Elizabeth A Winzeler; Alan F Cowman; Terence P Speed
A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays.
International journal for parasitology 2005;35(5):523-31.
2005: Manoj T Duraisingh; Till S Voss; Allison J Marty; Michael Duffy; Lucio Freitas-Junior; Jennifer K Thompson; Lúcio H Freitas-Junior; Artur Scherf; Brendan S Crabb; Alan F Cowman
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum.
Cell 2005;121(1):13-24.
2005: Julie Healer; Tony Triglia; Anthony N Hodder; Alan W Gemmill; Alan F Cowman
Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains.
Infection and immunity 2005;73(4):2444-51.
2005: Din Syafruddin; Puji B S Asih; Gerard J Casey; Jason Maguire; J Kevin Baird; Hadya S Nagesha; Alan F Cowman; John C Reeder
Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia.
The American journal of tropical medicine and hygiene 2005;72(2):174-81.
2005: J Andrew Pearce; Kerry Mills; Tony Triglia; Alan F Cowman; Robin F Anders
Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103.
Molecular and biochemical parasitology 2005;139(2):141-51.
2005: Tony Triglia; Manoj T Duraisingh; Rob Trygve Good; Alan F Cowman
Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum.
Molecular microbiology 2005;55(1):162-74.
2004: Matthias Marti; Rob Trygve Good; Melanie Rug; Ellen Knuepfer; Alan F Cowman
Targeting malaria virulence and remodeling proteins to the host erythrocyte.
Science (New York, N.Y.) 2004;306(5703):1930-3.
2004: Dominique Soldati; Bernardo J Foth; Alan F Cowman
Molecular and functional aspects of parasite invasion.
Trends in parasitology 2004;20(12):567-74.
2004: Sabine Wiek; Alan F Cowman; Klaus Lingelbach
Double cross-over gene replacement within the sec 7 domain of a GDP-GTP exchange factor from Plasmodium falciparum allows the generation of a transgenic brefeldin A-resistant parasite line.
Molecular and biochemical parasitology 2004;138(1):51-5.
2004: Melanie Rug; Mark E Wickham; Michael Foley; Alan F Cowman; Leann Tilley
Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites.
Infection and immunity 2004;72(10):6095-105.
2004: Waraporn Kasekarn; Rachada Sirawaraporn; Thippayarat Chahomchuen; Alan F Cowman; Worachart Sirawaraporn
Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum.
Molecular and biochemical parasitology 2004;137(1):43-53.
2004: Christopher J Tonkin; Giel G van Dooren; Timothy P Spurck; Nicole S Struck; Rob Trygve Good; Emanuela Handman; Alan F Cowman; Geoffrey I McFadden
Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method.
Molecular and biochemical parasitology 2004;137(1):13-21.
2004: Julie Healer; Vince J Murphy; Anthony N Hodder; Rosella Masciantonio; Alan W Gemmill; Robin F Anders; Alan F Cowman; Adrian H Batchelor
Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum.
Molecular microbiology 2004;52(1):159-68.
2004: J Andrew Pearce; Tony Triglia; Anthony N Hodder; David C Jackson; Alan F Cowman; Robin F Anders
Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen.
Infection and immunity 2004;72(4):2321-8.
2004: Conan Chow; Charles G Gauci; Alan F Cowman; Marshall W Lightowlers
Echinococcus granulosus: oncosphere-specific transcription of genes encoding a host-protective antigen.
Experimental parasitology 2004;106(3-4):183-6.
2004: Gerard J Casey; Meza Ginny; Merolyn Uranoli; Ivo Mueller; John C Reeder; Blaise Genton; Alan F Cowman
Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.
The American journal of tropical medicine and hygiene 2004;70(3):251-5.
2004: Brendan S Crabb; Melanie Rug; Tim-Wolf Gilberger; Jennifer K Thompson; Tony Triglia; Alexander G Maier; Alan F Cowman
Transfection of the human malaria parasite Plasmodium falciparum.
Methods in molecular biology (Clifton, N.J.) 2004;270():263-76.
2003: Alan F Cowman; Brendan S Crabb
Functional genomics: identifying drug targets for parasitic diseases.
Trends in parasitology 2003;19(11):538-43.
2003: Mark E Wickham; Janetta G Culvenor; Alan F Cowman
Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte.
The Journal of biological chemistry 2003;278(39):37658-63.
2003: Tim-Wolf Gilberger; Jennifer K Thompson; Michael B Reed; Rob Trygve Good; Alan F Cowman
The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking.
The Journal of cell biology 2003;162(2):317-27.
2003: Mark E Wickham; Jennifer K Thompson; Alan F Cowman
Characterisation of the merozoite surface protein-2 promoter using stable and transient transfection in Plasmodium falciparum.
Molecular and biochemical parasitology 2003;129(2):147-56.
2003: Tim-Wolf Gilberger; Jennifer K Thompson; Tony Triglia; Rob Trygve Good; Manoj T Duraisingh; Alan F Cowman
A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes.
The Journal of biological chemistry 2003;278(16):14480-6.
2003: Manoj T Duraisingh; Alexander G Maier; Tony Triglia; Alan F Cowman
Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4796-801.
2003: Manoj T Duraisingh; Tony Triglia; Stuart A Ralph; Julian C Rayner; John W Barnwell; Geoffrey I McFadden; Alan F Cowman
Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes.
The EMBO journal 2003;22(5):1047-57.
2003: Thanh Ngo; Manoj T Duraisingh; Michael Reed; David Hipgrave; Beverley-Ann Biggs; Alan F Cowman
Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin.
The American journal of tropical medicine and hygiene 2003;68(3):350-6.
2003: Akinola Adisa; Melanie Rug; Nectarios Klonis; Michael Foley; Alan F Cowman; Leann Tilley
The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites.
The Journal of biological chemistry 2003;278(8):6532-42.
2003: Bernardo J Foth; Stuart A Ralph; Christopher J Tonkin; Nicole S Struck; Martin J Fraunholz; David S Roos; Alan F Cowman; Geoffrey I McFadden
Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum.
Science (New York, N.Y.) 2003;299(5607):705-8.
2003: Ross F Waller; Stuart A Ralph; Michael B Reed; Vanessa Su; James D Douglas; David E Minnikin; Alan F Cowman; Gurdyal S Besra; Geoffrey I McFadden
A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2003;47(1):297-301.
2003: Alexander G Maier; Manoj T Duraisingh; John C Reeder; Sheral S Patel; James W Kazura; Peter Zimmerman; Alan F Cowman
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.
Nature medicine 2003;9(1):87-92.
2002: Susanne K Miller; Rob Trygve Good; Damien R Drew; Mauro Delorenzi; Paul R Sanders; Anthony N Hodder; Terence P Speed; Alan F Cowman; Tania F de Koning-Ward; Brendan S Crabb
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle.
The Journal of biological chemistry 2002;277(49):47524-32.
2002: Alan F Cowman; Brendan S Crabb
A parasite genome sheds light on an old enemy.
Nature biotechnology 2002;20(11):1098-9.
2002: Brendan S Crabb; Alan F Cowman
Plasmodium falciparum virulence determinants unveiled.
Genome biology 2002;3(11):REVIEWS1031.
2002: Alan F Cowman; Brendan S Crabb
The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
Science (New York, N.Y.) 2002;298(5591):126-8.
2002: Julie Healer; Simon Crawford; Stuart A Ralph; Geoff McFadden; Alan F Cowman
Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites.
Infection and immunity 2002;70(10):5751-8.
2002: Deborah L Baldi; Robert Good; Manoj T Duraisingh; Brendan S Crabb; Alan F Cowman
Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum.
Infection and immunity 2002;70(9):5236-45.
2002: Zita Krnajski; Tim-Wolf Gilberger; Rolf D Walter; Alan F Cowman; Sylke Müller
Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages.
The Journal of biological chemistry 2002;277(29):25970-5.
2002: Nectarios Klonis; Melanie Rug; Ian Harper; Mark E Wickham; Alan F Cowman; Leann Tilley
Fluorescence photobleaching analysis for the study of cellular dynamics.
European biophysics journal : EBJ 2002;31(1):36-51.
2002: Kerry Mills; J Andrew Pearce; Brendan S Crabb; Alan F Cowman
Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic-basic repeat protein to the surface of Plasmodium falciparum merozoites.
Molecular microbiology 2002;43(6):1401-11.
2002: Michael Duffy; Graham V Brown; Wanny Basuki; Efrosinia O Krejany; Rintis Noviyanti; Alan F Cowman; John C Reeder
Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype.
Molecular microbiology 2002;43(5):1285-93.
2002: Rebecca A O'Donnell; Lucio Freitas-Junior; Peter R Preiser; Donald H Williamson; Manoj T Duraisingh; Terry F McElwain; Artur Scherf; Alan F Cowman; Brendan S Crabb
A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes.
The EMBO journal 2002;21(5):1231-9.
2002: Fiona K Glenister; Ross Coppel; Alan F Cowman; Narla Mohandas; Brian M Cooke
Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells.
Blood 2002;99(3):1060-3.
2002: Alan F Cowman; Deborah L Baldi; Manoj T Duraisingh; Julie Healer; Kerry Mills; Rebecca A O'Donnell; Jennifer Thompson; Tony Triglia; Mark E Wickham; Brendan S Crabb
Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1417):25-33.
2002: Manoj T Duraisingh; Tony Triglia; Alan F Cowman
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
International journal for parasitology 2002;32(1):81-9.
2001: Conan Chow; Charles G Gauci; Alan F Cowman; Marshall W Lightowlers
A gene family expressing a host-protective antigen of Echinococcus granulosus.
Molecular and biochemical parasitology 2001;118(1):83-8.
2001: Mark E Wickham; Melanie Rug; Stuart A Ralph; Nectarios Klonis; Geoffrey I McFadden; Leann Tilley; Alan F Cowman
Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes.
The EMBO journal 2001;20(20):5636-49.
2001: N V Thanh; Alan F Cowman; David B Hipgrave; T B Kim; B Q Phuc; LD Cong; Beverley-Ann Biggs
Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern Viet Nam.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(5):513-7.
2001: Tony Triglia; Jennifer K Thompson; Alan F Cowman
An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum.
Molecular and biochemical parasitology 2001;116(1):55-63.
2001: Jennifer K Thompson; Tony Triglia; Michael B Reed; Alan F Cowman
A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes.
Molecular microbiology 2001;41(1):47-58.
2001: Alan F Cowman
Functional analysis of drug resistance in Plasmodium falciparum in the post-genomic era.
International journal for parasitology 2001;31(9):871-8.
2001: Rebecca A O'Donnell; Tania F de Koning-Ward; R A Burt; M Bockarie; John C Reeder; Alan F Cowman; Brendan S Crabb
Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria.
The Journal of experimental medicine 2001;193(12):1403-12.
2001: Helen M Taylor; Tony Triglia; J Thompson; M Sajid; R Fowler; Mark E Wickham; Alan F Cowman; Anthony A Holder
Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated.
Infection and immunity 2001;69(6):3635-45.
2001: Rintis Noviyanti; Graham V Brown; Mark E Wickham; Michael Duffy; Alan F Cowman; John C Reeder
Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion.
Molecular and biochemical parasitology 2001;114(2):227-37.
2001: JG Waterkeyn; Alan F Cowman; BM Cooke
Plasmodium falciparum: gelatin enrichment selects for parasites with full-length chromosome 2. implications for cytoadhesion assays.
Experimental parasitology 2001;97(2):115-8.
2001: Alan F Cowman; Manoj T Duraisingh
An old enemy, a new battle plan. Perspective on combating drug-resistant malaria.
EMBO reports 2001;2(2):77-9.
2001: Rebecca A O'Donnell; Peter R Preiser; Donald H Williamson; Peter W Moore; Alan F Cowman; Brendan S Crabb
An alteration in concatameric structure is associated with efficient segregation of plasmids in transfected Plasmodium falciparum parasites.
Nucleic acids research 2001;29(3):716-24.
2001: Tony Triglia; J Thompson; SR Caruana; Mauro Delorenzi; Terence P Speed; Alan F Cowman
Identification of proteins from Plasmodium falciparum that are homologous to reticulocyte binding proteins in Plasmodium vivax.
Infection and immunity 2001;69(2):1084-92.
2001: Hadya S Nagesha; Gerard J Casey; Augustina I Susanti; David J Fryauff; John C Reeder; Alan F Cowman
Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in West Papua, Indonesia.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(1):43-9.
2000: Tony Triglia; Julie Healer; SR Caruana; Anthony N Hodder; Robin F Anders; Brendan S Crabb; Alan F Cowman
Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species.
Molecular microbiology 2000;38(4):706-18.
2000: Alan F Cowman; Deborah L Baldi; Julie Healer; Kerry Mills; Rebecca A O'Donnell; Michael B Reed; Tony Triglia; Mark E Wickham; Brendan S Crabb
Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells.
FEBS letters 2000;476(1-2):84-8.
2000: Michael B Reed; SR Caruana; A H Batchelor; Jennifer K Thompson; Brendan S Crabb; Alan F Cowman
Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7509-14.
2000: JG Waterkeyn; Mark E Wickham; KM Davern; BM Cooke; Ross Coppel; John C Reeder; Janetta G Culvenor; Ross F Waller; Alan F Cowman
Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells.
The EMBO journal 2000;19(12):2813-23.
2000: Deborah L Baldi; K T Andrews; Ross F Waller; D S Roos; R F Howard; Brendan S Crabb; Alan F Cowman
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum.
The EMBO journal 2000;19(11):2435-43.
2000: Ross F Waller; Michael B Reed; Alan F Cowman; Geoffrey I McFadden
Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway.
The EMBO journal 2000;19(8):1794-802.
2000: Michael B Reed; Kevin Saliba; SR Caruana; K Kirk; Alan F Cowman
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.
Nature 2000;403(6772):906-9.
2000: Rebecca A O'Donnell; Allan Saul; Alan F Cowman; Brendan S Crabb
Functional conservation of the malaria vaccine antigen MSP-119across distantly related Plasmodium species.
Nature medicine 2000;6(1):91-5.
1999: Sansanee C Chaiyaroj; A Buranakiti; Pornpimon Angkasekwinai; S Looressuwan; Alan F Cowman
Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand.
The American journal of tropical medicine and hygiene 1999;61(5):780-3.
1999: Jennifer K Thompson; SR Caruana; Alan F Cowman
YAC contigs and restriction maps of chromosomes 4 and 5 from the cloned line 3D7 of Plasmodium falciparum.
Molecular and biochemical parasitology 1999;102(1):197-204.
1999: JG Waterkeyn; B S Crabb; Alan F Cowman
Transfection of the human malaria parasite Plasmodium falciparum.
International journal for parasitology 1999;29(6):945-55.
1999: Tony Triglia; Alan F Cowman
Plasmodium falciparum: a homologue of p-aminobenzoic acid synthetase.
Experimental parasitology 1999;92(2):154-8.
1999: John C Reeder; Alan F Cowman; KM Davern; James G Beeson; Jennifer K Thompson; Stephen J Rogerson; Graham V Brown
The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5198-202.
1998: Ross F Waller; Patrick J Keeling; Robert G K Donald; Boris Striepen; Emanuela Handman; N Lang-Unnasch; Alan F Cowman; Gurdyal S Besra; David S Roos; Geoffrey I McFadden
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12352-7.
1998: Tony Triglia; P Wang; Paul F G Sims; John E Hyde; Alan F Cowman
Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria.
The EMBO journal 1998;17(14):3807-15.
1998: A J Humberstone; Alan F Cowman; J Horton; William N Charman
Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum.
Journal of pharmaceutical sciences 1998;87(2):256-8.
1998: JG Waterkeyn; Charles G Gauci; Alan F Cowman; Marshall W Lightowlers
Codon usage in Taenia species.
Experimental parasitology 1998;88(1):76-8.
1997: Jennifer K Thompson; Alan F Cowman
A YAC contig and high resolution restriction map of chromosome 3 from Plasmodium falciparum.
Molecular and biochemical parasitology 1997;90(2):537-42.
1997: Tony Triglia; J G Menting; C Wilson; Alan F Cowman
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13944-9.
1997: Brendan S Crabb; Tony Triglia; JG Waterkeyn; Alan F Cowman
Stable transgene expression in Plasmodium falciparum.
Molecular and biochemical parasitology 1997;90(1):131-44.
1997: J G Menting; Leann Tilley; Leslie W Deady; K Ng; R J Simpson; Alan F Cowman; Michael Foley
The antimalarial drug, chloroquine, interacts with lactate dehydrogenase from Plasmodium falciparum.
Molecular and biochemical parasitology 1997;88(1-2):215-24.
1997: Jennifer K Thompson; Justin P Rubio; SR Caruana; A Brockman; Mark E Wickham; Alan F Cowman
The chromosomal organization of the Plasmodium falciparum var gene family is conserved.
Molecular and biochemical parasitology 1997;87(1):49-60.
1997: JG Waterkeyn; C Gauci; Alan F Cowman; Marshall W Lightowlers
Sequence analysis of a gene family encoding Taenia ovis vaccine antigens expressed during embryogenesis of eggs.
Molecular and biochemical parasitology 1997;86(1):75-84.
1997: JG Waterkeyn; Alan F Cowman; Marshall W Lightowlers
Taenia ovis: copy number of genes encoding host-protective antigens determined by competitive PCR.
Experimental parasitology 1997;86(1):84-8.
1997: Brendan S Crabb; BM Cooke; John C Reeder; Ross F Waller; SR Caruana; KM Davern; Mark E Wickham; Graham V Brown; Ross Coppel; Alan F Cowman
Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress.
Cell 1997;89(2):287-96.
1996: J Desneves; G Thorn; A Berman; Denise Galatis; N La Greca; J Sinding; Michael Foley; Leslie W Deady; Alan F Cowman; Leann Tilley
Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes.
Molecular and biochemical parasitology 1996;82(2):181-94.
1996: C D Riffkin; R Chung; D M Wall; John Zalcberg; Alan F Cowman; Michael Foley; Leann Tilley
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.
Biochemical pharmacology 1996;52(10):1545-52.
1996: Z Bozdech; U Delling; Sarah K Volkman; Alan F Cowman; Erwin Schurr
Cloning and sequence analysis of a novel member of the ATP-binding cassette (ABC) protein gene family from Plasmodium falciparum.
Molecular and biochemical parasitology 1996;81(1):41-51.
1996: A S Lim; Denise Galatis; Alan F Cowman
Plasmodium falciparum: amplification and overexpression of pfmdr1 is not necessary for increased mefloquine resistance.
Experimental parasitology 1996;83(3):295-303.
1996: A S Lim; Alan F Cowman
Plasmodium falciparum: chloroquine selection of a cloned line and DNA rearrangements.
Experimental parasitology 1996;83(3):283-94.
1996: John C Reeder; K H Rieckmann; Blaise Genton; K Lorry; B Wines; Alan F Cowman
Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea.
The American journal of tropical medicine and hygiene 1996;55(2):209-13.
1996: J P Rubio; Jennifer K Thompson; Alan F Cowman
The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes.
The EMBO journal 1996;15(15):4069-77.
1996: Brendan S Crabb; Alan F Cowman
Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7289-94.
1996: J P Rubio; Alan F Cowman
The ATP-binding cassette (ABC) gene family of Plasmodium falciparum.
Parasitology today (Personal ed.) 1996;12(4):135-40.
1995: Alan F Cowman
Mechanisms of drug resistance in malaria.
Australian and New Zealand journal of medicine 1995;25(6):837-44.
1995: F Trottein; T Triglia; Alan F Cowman
Molecular cloning of a gene from Plasmodium falciparum that codes for a protein sharing motifs found in adhesive molecules from mammals and plasmodia.
Molecular and biochemical parasitology 1995;74(2):129-41.
1995: Sarah K Volkman; Alan F Cowman; Dyann F Wirth
Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8921-5.
1995: JG Waterkeyn; Marshall W Lightowlers; Ross Coppel; Alan F Cowman
Characterization of the gene family encoding a host-protective antigen of the tapeworm Taenia ovis.
Molecular and biochemical parasitology 1995;73(1-2):123-31.
1995: F Trottein; J Thompson; Alan F Cowman
Cloning of a new cation ATPase from Plasmodium falciparum: conservation of critical amino acids involved in calcium binding in mammalian organellar Ca(2+)-ATPases.
Gene 1995;158(1):133-7.
1995: XF Hu; A Slater; D M Wall; Phillip Kantharidis; J D Parkin; Alan F Cowman; John Zalcberg
Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line.
British journal of cancer 1995;71(5):931-6.
1995: J P Rubio; T Triglia; D J Kemp; D de Bruin; Jeffrey V Ravetch; Alan F Cowman
A YAC contig map of Plasmodium falciparum chromosome 4: characterization of a DNA amplification between two recently separated isolates.
Genomics 1995;26(2):192-8.
1995: F Trottein; Alan F Cowman
The primary structure of a putative phosphatidylethanolamine-binding protein from Plasmodium falciparum.
Molecular and biochemical parasitology 1995;70(1-2):235-9.
1995: F Trottein; Alan F Cowman
Molecular cloning and sequence of two novel P-type adenosinetriphosphatases from Plasmodium falciparum.
European journal of biochemistry / FEBS 1995;227(1-2):214-25.
1995: K Raynes; Denise Galatis; Alan F Cowman; Leann Tilley; Leslie W Deady
Synthesis and activity of some antimalarial bisquinolines.
Journal of medicinal chemistry 1995;38(1):204-6.
1994: J P Rubio; Alan F Cowman
Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite.
Experimental parasitology 1994;79(2):137-47.
1994: T Triglia; Alan F Cowman
Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7149-53.
1994: S R Karcz; V R Herrmann; F Trottein; Alan F Cowman
Cloning and characterization of the vacuolar ATPase B subunit from Plasmodium falciparum.
Molecular and biochemical parasitology 1994;65(1):123-33.
1994: H H van Es; S Karcz; F Chu; Alan F Cowman; S Vidal; Philippe Gros; Erwin Schurr
Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine.
Molecular and cellular biology 1994;14(4):2419-28.
1994: Michael Foley; Leslie W Deady; K Ng; Alan F Cowman; Leann Tilley
Photoaffinity labeling of chloroquine-binding proteins in Plasmodium falciparum.
The Journal of biological chemistry 1994;269(9):6955-61.
1994: Simon J Foote; Alan F Cowman
The mode of action and the mechanism of resistance to antimalarial drugs.
Acta tropica 1994;56(2-3):157-71.
1994: Alan F Cowman; Denise Galatis; J K Thompson
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):1143-7.
1993: A S Lim; Alan F Cowman
Phosphorylation of a P-glycoprotein homologue in Plasmodium falciparum.
Molecular and biochemical parasitology 1993;62(2):293-302.
1993: S R Karcz; V R Herrmann; Alan F Cowman
Cloning and characterization of a vacuolar ATPase A subunit homologue from Plasmodium falciparum.
Molecular and biochemical parasitology 1993;58(2):333-44.
1993: S R Karcz; Denise Galatis; Alan F Cowman
Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum.
Molecular and biochemical parasitology 1993;58(2):269-76.
1993: Alan F Cowman; S Karcz
Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum.
Seminars in cell biology 1993;4(1):29-35.
1992: Roberto Cappai; D C Kaslow; M G Peterson; Alan F Cowman; Robin F Anders; D J Kemp
Cloning and analysis of the RESA-2 gene: a DNA homologue of the ring-infected erythrocyte surface antigen gene of Plasmodium falciparum.
Molecular and biochemical parasitology 1992;54(2):213-21.
1992: Roberto Cappai; Alan F Cowman
The Plasmodium falciparum hypoxanthine-guanine phosphoribosyl transferase gene has a 5' upstream intron.
Molecular and biochemical parasitology 1992;54(1):117-20.
1992: D A Barnes; Simon J Foote; Denise Galatis; D J Kemp; Alan F Cowman
Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum.
The EMBO journal 1992;11(8):3067-75.
1991: T Triglia; Simon J Foote; D J Kemp; Alan F Cowman
Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events.
Molecular and cellular biology 1991;11(10):5244-50.
1991: Alan F Cowman; Denise Galatis
Plasmodium falciparum: the calmodulin gene is not amplified or overexpressed in chloroquine resistant or sensitive isolates.
Experimental parasitology 1991;73(3):269-75.
1991: S Karcz; Alan F Cowman
Similarities and differences between the multidrug resistance phenotype of mammalian tumor cells and chloroquine resistance in Plasmodium falciparum.
Experimental parasitology 1991;73(2):233-40.
1991: Alan F Cowman; S Karcz; Denise Galatis; Janetta G Culvenor
A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole.
The Journal of cell biology 1991;113(5):1033-42.
1991: Alan F Cowman
The P-glycoprotein homologues of Plasmodium falciparum: Are they involved in chloroquine resistance?
Parasitology today (Personal ed.) 1991;7(4):70-6.
1991: Alan F Cowman; S R Karcz
The pfmdr gene homologues of Plasmodium falciparum.
Acta Leidensia 1991;60(1):121-9.
1990: Alan F Cowman; Andrew M Lew
Chromosomal rearrangements and point mutations in the DHFR-TS gene of Plasmodium chabaudi under antifolate selection.
Molecular and biochemical parasitology 1990;42(1):21-9.
1990: Alan F Cowman; Simon J Foote
Chemotherapy and drug resistance in malaria.
International journal for parasitology 1990;20(4):503-13.
1990: Simon J Foote; Dennis E Kyle; R K Martin; Ayoade Oduola; K Forsyth; D J Kemp; Alan F Cowman
Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.
Nature 1990;345(6272):255-8.
1990: Simon J Foote; Denise Galatis; Alan F Cowman
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3014-7.
1990: D J Kemp; Alan F Cowman; D Walliker
Genetic diversity in Plasmodium falciparum.
Advances in parasitology 1990;29():75-149.
1989: Alan F Cowman; Andrew M Lew
Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi.
Molecular and cellular biology 1989;9(11):5182-8.
1989: Roberto Cappai; M R van Schravendijk; Robin F Anders; M G Peterson; L M Thomas; Alan F Cowman; D J Kemp
Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion.
Molecular and cellular biology 1989;9(8):3584-7.
1989: Simon J Foote; J K Thompson; Alan F Cowman; D J Kemp
Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum.
Cell 1989;57(6):921-30.
1988: Alan F Cowman; M J Morry; B A Biggs; G A Cross; Simon J Foote
Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9109-13.
1987: R B Saint; Ross Coppel; Alan F Cowman; G V Brown; P T Shi; N Barzaga; D J Kemp; Robin F Anders
Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum.
Molecular and cellular biology 1987;7(8):2968-73.