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Antti Haapalinna

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Tiina Leino; Timo Viitamaa; Antti Haapalinna; Jyrki Lehtimäki; Raine Virtanen
Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.
Jyrki Lehtimäki; Tiina Leino; Ari Koivisto; Timo Viitamaa; Tarja Lehtimäki; Antti Haapalinna; Katja Kuokkanen; Raimo Virtanen
In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.
Jukka Sallinen; I Höglund; Mia Engström; J Lehtimäki; Raine Virtanen; Jouni Sirviö; Siegfried Wurster; Juha-Matti Savola; Antti Haapalinna
Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.

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All Publications

2009: Tiina Leino; Timo Viitamaa; Antti Haapalinna; Jyrki Lehtimäki; Raine Virtanen
Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.
Naunyn-Schmiedeberg's archives of pharmacology 2009;380(6):539-50.
2008: Jyrki Lehtimäki; Tiina Leino; Ari Koivisto; Timo Viitamaa; Tarja Lehtimäki; Antti Haapalinna; Katja Kuokkanen; Raimo Virtanen
In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.
European journal of pharmacology 2008;599(1-3):65-71.
2007: Jukka Sallinen; I Höglund; Mia Engström; J Lehtimäki; Raine Virtanen; Jouni Sirviö; Siegfried Wurster; Juha-Matti Savola; Antti Haapalinna
Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.
British journal of pharmacology 2007;150(4):391-402.
2006: Timo Viitamaa; Antti Haapalinna; Anders Agmo
The adrenergic alpha2 receptor and sexual incentive motivation in male rats.
Pharmacology, biochemistry, and behavior 2006;83(3):360-9.
2005: Juuso Juhila; Aapo Honkanen; Jukka Sallinen; Antti Haapalinna; Esa R Korpi; Mika Scheinin
alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice.
European journal of pharmacology 2005;517(1-2):74-83.
2005: Antti Pertovaara; Antti Haapalinna; Jouni Sirviö; Raine Virtanen
Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist.
CNS drug reviews 2005;11(3):273-88.
2004: Asla Pitkänen; Susanna Narkilahti; Zinayida Bezvenyuk; Antti Haapalinna; Jari Nissinen
Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats.
Epilepsy research 2004;61(1-3):119-40.
2004: Sarita Forsback; Riitta Niemi; Päivi Marjamäki; Olli Eskola; Jörgen Bergman; Tove Grönroos; Merja Haaparanta; Antti Haapalinna; Juha Rinne; Olof Solin
Uptake of 6-[18F]fluoro-L-dopa and [18F]CFT reflect nigral neuronal loss in a rat model of Parkinson's disease.
Synapse (New York, N.Y.) 2004;51(2):119-27.
2003: M Niittykoski; Antti Haapalinna; Jouni Sirviö
Selegiline reduces N-methyl-D-aspartic acid induced perturbation of neurotransmission but it leaves NMDA receptor dependent long-term potentiation intact in the hippocampus.
Journal of neural transmission (Vienna, Austria : 1996) 2003;110(11):1225-40.
2003: Antti Haapalinna; Tiina Leino; Esa Heinonen
The alpha 2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(5):342-51.
2003: Tiina Koskinen; Antti Haapalinna; Jouni Sirviö
Alpha-adrenoceptor-mediated modulation of 5-HT2 receptor agonist induced impulsive responding in a 5-choice serial reaction time task.
Pharmacology & toxicology 2003;92(5):214-25.
2003: Juuso Juhila; Antti Haapalinna; Jouni Sirviö; Jukka Sallinen; Aapo Honkanen; Esa R Korpi; Mika Scheinin
The alpha2-adrenoceptor antagonist atipamezole reduces the development and expression of d-amphetamine-induced behavioural sensitization.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(3):274-80.
2003: Leonid Yavich; Jouni Sirviö; Antti Haapalinna; Aarne Ylinen; Pekka T Männistö
Atipamezole, an alpha2-adrenoceptor antagonist, augments the effects of L-DOPA on evoked dopamine release in rat striatum.
European journal of pharmacology 2003;462(1-3):83-9.
2001: Alexandra Barbelivien; L Nyman; Antti Haapalinna; Jouni Sirviö
Inhibition of MAO-A activity enhances behavioural activity of rats assessed using water maze and open arena tasks.
Pharmacology & toxicology 2001;88(6):304-12.
2001: Mika Scheinin; Jukka Sallinen; Antti Haapalinna
Evaluation of the alpha2C-adrenoceptor as a neuropsychiatric drug target studies in transgenic mouse models.
Life sciences 2001;68(19-20):2277-85.
2001: Kirsi Puurunen; Jukka Jolkkonen; Jouni Sirviö; Antti Haapalinna; Juhani Sivenius
An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats.
Neuropharmacology 2001;40(4):597-606.
2001: Kirsi Puurunen; Jukka Jolkkonen; Jouni Sirviö; Antti Haapalinna; Juhani Sivenius
Selegiline combined with enriched-environment housing attenuates spatial learning deficits following focal cerebral ischemia in rats.
Experimental neurology 2001;167(2):348-55.
2001: Johanna Kuhmonen; Antti Haapalinna; Juhani Sivenius
Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat.
Journal of neural transmission (Vienna, Austria : 1996) 2001;108(3):261-71.
2000: Olga Vekovischeva; Antti Haapalinna; R Näkki; Maija Sarviharju; Aapo Honkanen; J Heikkilä; Esa R Korpi
Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.
Pharmacology, biochemistry, and behavior 2000;67(4):793-9.
2000: Jukka Jolkkonen; Risto A Kauppinen; L Nyman; Antti Haapalinna; Juhani Sivenius
MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.
Pharmacology & toxicology 2000;87(5):242-5.
2000: Jukka Jolkkonen; Kirsi Puurunen; S Rantakömi; A Härkönen; Antti Haapalinna; Juhani Sivenius
Behavioral effects of the alpha(2)-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats.
European journal of pharmacology 2000;400(2-3):211-9.
2000: M Niittykoski; Antti Haapalinna; Jouni Sirviö
Diminution of N-methyl-D-aspartate-induced perturbation of neurotransmission by dexmedetomidine in the CA1 field of rat hippocampus in vitro.
Neuroscience letters 2000;281(2-3):95-8.
2000: Antti Haapalinna; Jouni Sirviö; Ewen MacDonald; Raine Virtanen; Esa Heinonen
The effects of a specific alpha(2)-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats.
European journal of pharmacology 2000;387(2):141-50.
2000: Johanna Kuhmonen; Jukka Jolkkonen; Antti Haapalinna; Juhani Sivenius
The neuroprotective effects of (-)deprenyl in the gerbil hippocampus following transient global ischemia.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(7):779-86.
1999: Päivi Riihioja; Pia Jaatinen; Antti Haapalinna; Kalervo Kiianmaa; Antti Hervonen
Effects of ageing and intermittent ethanol exposure on rat locus coeruleus and ethanol-withdrawal symptoms.
Alcohol and alcoholism (Oxford, Oxfordshire) 1999;34(5):706-17.
1999: Jukka Sallinen; Antti Haapalinna; Ewen MacDonald; Timo Viitamaa; Janne Lähdesmäki; Elena Rybnikova; Markku Pelto-Huikko; BK Kobilka; Mika Scheinin
Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
Molecular psychiatry 1999;4(5):443-52.
1999: Olga Vekovischeva; Antti Haapalinna; Maija Sarviharju; Aapo Honkanen; Esa R Korpi
Cerebellar GABA(A) receptors and anxiolytic action of diazepam.
Brain research 1999;837(1-2):184-7.
1999: Erkki Tupala; Antti Haapalinna; Timo Viitamaa; Pekka T Männistö; Veijo Saano
Effects of repeated low dose administration and withdrawal of haloperidol on sexual behaviour of male rats.
Pharmacology & toxicology 1999;84(6):292-5.
1999: Jukka Jolkkonen; Kirsi Puurunen; Jari Koistinaho; Risto A Kauppinen; Antti Haapalinna; L Nieminen; Juhani Sivenius
Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia.
European journal of pharmacology 1999;372(1):31-6.
1999: M Niittykoski; Sirja Ruotsalainen; Antti Haapalinna; John Larson; Jouni Sirviö
Activation of muscarinic M3-like receptors and beta-adrenoceptors, but not M2-like muscarinic receptors or alpha-adrenoceptors, directly modulates corticostriatal neurotransmission in vitro.
Neuroscience 1999;90(1):95-105.
1999: Antti Haapalinna; Ewen MacDonald; Timo Viitamaa; J S Salonen; Jouni Sirviö; Raine Virtanen
Comparison of the effects of acute and subchronic administration of atipamezole on reaction to novelty and active avoidance learning in rats.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(3):194-203.
1999: Päivi Riihioja; Pia Jaatinen; Antti Haapalinna; Kalervo Kiianmaa; Antti Hervonen
Effects of dexmedetomidine on rat locus coeruleus and ethanol withdrawal symptoms during intermittent ethanol exposure.
Alcoholism, clinical and experimental research 1999;23(3):432-8.
1998: M Niittykoski; R Lappalainen; Jukka Jolkkonen; Antti Haapalinna; P Riekkinen; Jouni Sirviö
Systemic administration of atipamezole, a selective antagonist of alpha-2 adrenoceptors, facilitates behavioural activity but does not influence short-term or long-term memory in trimethyltin-intoxicated and control rats.
Neuroscience and biobehavioral reviews 1998;22(6):735-50.
1998: Jukka Sallinen; Antti Haapalinna; Timo Viitamaa; BK Kobilka; Mika Scheinin
D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype.
Neuroscience 1998;86(3):959-65.
1998: Antti Haapalinna; Jouni Sirviö; R Lammintausta
Facilitation of cognitive functions by a specific alpha2-adrenoceptor antagonist, atipamezole.
European journal of pharmacology 1998;347(1):29-40.
1998: Jukka Sallinen; Antti Haapalinna; Timo Viitamaa; BK Kobilka; Mika Scheinin
Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(8):3035-42.
1998: T Puumala; S Greijus; K Narinen; Antti Haapalinna; P Riekkinen; Jouni Sirviö
Stimulation of alpha-1 adrenergic receptors facilitates spatial learning in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1998;8(1):17-26.
1998: Sirja Ruotsalainen; Ewen MacDonald; Esa H Koivisto; R Stefanski; Antti Haapalinna; PJ Riekkinen; Jouni Sirviö
5-HT1A receptor agonist (8-OH-DPAT) and 5-HT2 receptor agonist (DOI) disrupt the non-cognitive performance of rats in a working memory task.
Journal of psychopharmacology (Oxford, England) 1998;12(2):177-85.
1997: Leonid Yavich; R Lappalainen; Jouni Sirviö; Antti Haapalinna; Ewen MacDonald
Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum.
European journal of pharmacology 1997;339(2-3):113-9.
1997: Antti Haapalinna; Timo Viitamaa; Ewen MacDonald; Juha-Matti Savola; L Tuomisto; Raine Virtanen; Esa Heinonen
Evaluation of the effects of a specific alpha 2-adrenoceptor antagonist, atipamezole, on alpha 1- and alpha 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(5):570-82.
1997: Päivi Riihioja; Pia Jaatinen; H Oksanen; Antti Haapalinna; Esa Heinonen; Antti Hervonen
Dexmedetomidine alleviates ethanol withdrawal symptoms in the rat.
Alcohol (Fayetteville, N.Y.) 1997;14(6):537-44.
1997: M Niittykoski; V Hakkarainen; T Puumala; R Lappalainen; Sirja Ruotsalainen; Antti Haapalinna; Jouni Sirviö
Systemic administration of atipamezole, an alpha 2-antagonist, can reduce scopolamine-induced hyperactivity in rats.
Behavioural pharmacology 1997;8(5):465-70.
1997: Johanna Kuhmonen; J Pokorný; Riitta Miettinen; Antti Haapalinna; Jukka Jolkkonen; PJ Riekkinen; Juhani Sivenius
Neuroprotective effects of dexmedetomidine in the gerbil hippocampus after transient global ischemia.
Anesthesiology 1997;87(2):371-7.
1997: Päivi Riihioja; Pia Jaatinen; H Oksanen; Antti Haapalinna; Esa Heinonen; Antti Hervonen
Dexmedetomidine, diazepam, and propranolol in the treatment of ethanol withdrawal symptoms in the rat.
Alcoholism, clinical and experimental research 1997;21(5):804-8.
1997: H Lahtinen; Jari Koistinaho; Risto A Kauppinen; Antti Haapalinna; Riitta Keinänen; Juhani Sivenius
Selegiline treatment after transient global ischemia in gerbils enhances the survival of CA1 pyramidal cells in the hippocampus.
Brain research 1997;757(2):260-7.
1997: Kirsi Puurunen; Jouni Sirviö; Jari Koistinaho; Riitta Miettinen; Antti Haapalinna; PJ Riekkinen; Juhani Sivenius
Studies on the influence of enriched-environment housing combined with systemic administration of an alpha2-adrenergic antagonist on spatial learning and hyperactivity after global ischemia in rats.
Stroke; a journal of cerebral circulation 1997;28(3):623-31.
1997: T Puumala; Markus Björklund; Sirja Ruotsalainen; Mervi S Riekkinen; Pekka Jäkälä; Antti Haapalinna; EA Björk; PJ Riekkinen; Jouni Sirviö
Lack of relationship between thalamic oscillations and attention in rats: differential modulation by an alpha-2 antagonist.
Brain research bulletin 1997;43(2):163-71.
1997: R Liljequist; Antti Haapalinna; M Ahlander; Y H Li; Pekka T Männistö
Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats.
Behavioural brain research 1997;82(2):195-202.
1997: Jukka Sallinen; R E Link; Antti Haapalinna; Timo Viitamaa; M Kulatunga; B Sjöholm; Ewen MacDonald; Markku Pelto-Huikko; T Leino; G S Barsh; BK Kobilka; Mika Scheinin
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.
Molecular pharmacology 1997;51(1):36-46.
1997: Raimo Pussinen; Sakari Nieminen; Esa H Koivisto; Antti Haapalinna; PJ Riekkinen; J Sirvio
Enhancement of intermediate-term memory by an alpha-1 agonist or a partial agonist at the glycine site of the NMDA receptor.
Neurobiology of learning and memory 1997;67(1):69-74.
1997: Sirja Ruotsalainen; Antti Haapalinna; P J Riekkinen; Jouni Sirviö
Dexmedetomidine reduces response tendency, but not accuracy of rats in attention and short-term memory tasks.
Pharmacology, biochemistry, and behavior 1997;56(1):31-40.
1996: Leonid Yavich; Jouni Sirviö; Antti Haapalinna; T Puumala; Esa H Koivisto; EH Heinonen; PJ Riekkinen
The systemic administration of tacrine or selegiline facilitate spatial learning in aged fisher 344 rats.
Journal of neural transmission (Vienna, Austria : 1996) 1996;103(5):619-26.
1996: T Salonen; Antti Haapalinna; Esa Heinonen; J Suhonen; Antti Hervonen
Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity.
Acta neuropathologica 1996;91(5):466-74.
1995: P Valtonen; Antti Haapalinna; PJ Riekkinen; Toivo Halonen
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
European journal of pharmacology 1995;285(3):239-46.
1995: Pia Jaatinen; Päivi Riihioja; Antti Haapalinna; Esa Heinonen; Kalervo Kiianmaa; Antti Hervonen
Prevention of ethanol-induced sympathetic overactivity and degeneration by dexmedetomidine.
Alcohol (Fayetteville, N.Y.) 1995;12(5):439-46.
1994: Leonid Yavich; Jouni Sirviö; Antti Haapalinna; PJ Riekkinen
Some unusual effects of alpha 2-adrenergic drugs on cortical high voltage spindles in rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1994;4(4):535-8.
1994: Jouni Sirviö; M Mazurkiewicz; Antti Haapalinna; P Riekkinen; H Lahtinen; PJ Riekkinen
The effects of selective alpha-2 adrenergic agents on the performance of rats in a 5-choice serial reaction time task.
Brain research bulletin 1994;35(5-6):451-5.
1993: Jouni Sirviö; Pekka Jäkälä; M Mazurkiewicz; Antti Haapalinna; P Riekkinen; PJ Riekkinen
Dose- and parameter-dependent effects of atipamezole, an alpha 2-antagonist, on the performance of rats in a five-choice serial reaction time task.
Pharmacology, biochemistry, and behavior 1993;45(1):123-9.
1992: Pekka Jäkälä; Timo Viitamaa; Jouni Sirviö; PJ Riekkinen; J Salonen; Antti Haapalinna; Raine Virtanen; P Riekkinen
Continuous alpha 2-adrenoceptor blockade by atipamezole decreases neocortical high-voltage spindle activity in rats.
European journal of pharmacology 1992;221(2-3):351-7.
1992: Jouni Sirviö; M Harju; P Riekkinen; Antti Haapalinna; PJ Riekkinen
Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task.
Psychopharmacology 1992;109(1-2):127-33.
1989: E MacDonald; Antti Haapalinna; Raine Virtanen; R Lammintausta
Effects of acute administration of medetomidine on the behaviour, temperature and turnover rates of brain biogenic amines in rodents and reversal of these effects by atipamezole.
Acta veterinaria Scandinavica. Supplementum 1989;85():77-81.