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Grahame Hardie

Research Profile

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TOP 3
Madhumita Dandapani; D Grahame Hardie
AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
D Grahame Hardie
Metformin-acting through cyclic AMP as well as AMP?
D Grahame Hardie
The LKB1-AMPK pathway-friend or foe in cancer?

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All Publications

2013: Madhumita Dandapani; D Grahame Hardie
AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
Biochemical Society transactions 2013;41(2):687-93.
2013: D Grahame Hardie
Metformin-acting through cyclic AMP as well as AMP?
Cell metabolism 2013;17(3):313-4.
2013: D Grahame Hardie
The LKB1-AMPK pathway-friend or foe in cancer?
Cancer cell 2013;23(2):131-2.
2013: Luke A J O'Neill; D Grahame Hardie
Metabolism of inflammation limited by AMPK and pseudo-starvation.
Nature 2013;493(7432):346-55.
2013: D Grahame Hardie; Dario R Alessi
LKB1 and AMPK and the cancer-metabolism link - ten years after.
BMC biology 2013;11():36.
2012: D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMP-activated protein kinase: a target for drugs both ancient and modern.
Chemistry & biology 2012;19(10):1222-36.
2012: Chi-Wai Lee; Joyce Man-Fong Lee; Veronica Yee-Law Leong; Heong-Fai Liu; Irene Oi-Lin Ng; Edith Yuk-Ting Tse; Leo Lap-Yan Wong; D Grahame Hardie; Yick-Pang Ching
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.
Cancer research 2012;72(17):4394-404.
2012: Sophie Turban; Benoit Viollet; Maria L Watson; Olivier Drouin; Alexander Gray; Charlotte J Green; D Grahame Hardie; Louise Lantier; Andre Marette; Fiona Ross; Clare Stretton; Harinder S Hundal
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.
The Journal of biological chemistry 2012;287(24):20088-99.
2012: Simon A Hawley; Bruce E Kemp; Kirsty J Mustard; Mark W Peggie; Fiona A Ross; Kei Sakamoto; Jonathan D Schertzer; Gregory R Steinberg; Katherine J Walker; Darya Zibrova; Cyrille Chevtzoff; Morgan D Fullerton; Kevin A Green; D Grahame Hardie
The ancient drug salicylate directly activates AMP-activated protein kinase.
Science (New York, N.Y.) 2012;336(6083):918-22.
2012: D Grahame Hardie
Organismal carbohydrate and lipid homeostasis.
Cold Spring Harbor perspectives in biology 2012;4(5):.
2012: D Grahame Hardie; Fiona A Ross; Simon A Hawley
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
Nature reviews. Molecular cell biology 2012;13(4):251-62.
2012: A Mark Evans; Prem Kumar; Chris Peers; Christopher N Wyatt; D Grahame Hardie
Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level.
Advances in experimental medicine and biology 2012;758():81-90.
2011: Naoko Ikematsu; Ryan W Lewis; Chris Peers; J Nicole Rafferty; Fiona A Ross; Rakesh Suman; Mark L Dallas; Jonathan A David; D Grahame Hardie; A Mark Evans
Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(44):18132-7.
2011: D Grahame Hardie
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.
Genes & development 2011;25(18):1895-908.
2011: D Grahame Hardie; David Carling; Steven J Gamblin
AMP-activated protein kinase: also regulated by ADP?
Trends in biochemical sciences 2011;36(9):470-7.
2011: Pauline M Jamieson; P A T Kelly; Y Kuperman; Nicholas M Morton; K J Mustard; Jonathan R Seckl; David G Brownstein; R N Carter; Alon Chen; M E Cleasby; C N Hahn; D Grahame Hardie; J M Vaughan; Wylie W Vale
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.
Diabetologia 2011;54(9):2392-403.
2011: Sirwan Hadad; D Grahame Hardie; Takayuki Iwamoto; Gera Jellema; Lee Jordan; Stacy Moulder-Thompson; Colin Purdie; Lajos Pusztai; Lee Baker; Susan Bray; Steve Deharo; John A Dewar; Alastair Thompson
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.
Breast cancer research and treatment 2011;128(3):783-94.
2011: Stephanie zur Nedden; Simon Hawley; Naomi Pentland; D Grahame Hardie; Alexander S Doney; Bruno G Frenguelli
Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(16):6221-34.
2011: Charlotte J Green; D Grahame Hardie; Katherine Macrae; Kei Sakamoto; Sarah Fogarty; Harinder S Hundal
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.
The Biochemical journal 2011;435(2):463-74.
2011: D Grahame Hardie
Signal transduction: How cells sense energy.
Nature 2011;472(7342):176-7.
2011: Fiona A Ross; J Nicole Rafferty; Mark L Dallas; Oluseye Ogunbayo; Naoko Ikematsu; Heather McClafferty; Lijun Tian; Helene Widmer; Iain C M Rowe; Christopher N Wyatt; Michael J Shipston; Chris Peers; D Grahame Hardie; A Mark Evans
Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase.
The Journal of biological chemistry 2011;286(14):11929-36.
2011: D Grahame Hardie
Sensing of energy and nutrients by AMP-activated protein kinase.
The American journal of clinical nutrition 2011;93(4):891S-6.
2011: D Grahame Hardie
AMPK and autophagy get connected.
The EMBO journal 2011;30(4):634-5.
2011: A Mark Evans; D Grahame Hardie; Chris Peers; Amira Mahmoud
Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing.
Current opinion in anaesthesiology 2011;24(1):13-20.
2011: D Grahame Hardie
Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism.
The Proceedings of the Nutrition Society 2011;70(1):92-9.
2011: D Grahame Hardie
Cell biology. Why starving cells eat themselves.
Science (New York, N.Y.) 2011;331(6016):410-1.
2011: D Grahame Hardie
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.
Biochemical Society transactions 2011;39(1):1-13.
2010: D Grahame Hardie
Hot stuff: thyroid hormones and AMPK.
Cell research 2010;20(12):1282-4.
2010: Kristian Kiilerich; Helle Adser; Anne H Jakobsen; Per A Pedersen; D Grahame Hardie; Jorgen F P Wojtaszewski; Henriette Pilegaard
PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(5):R1350-9.
2010: D Grahame Hardie
Transcription. Targeting the core of transcription.
Science (New York, N.Y.) 2010;329(5996):1158-9.
2010: Daniel Moreno; Mhairi C Towler; D Grahame Hardie; Erwin Knecht; Pascual Sanz
The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Molecular biology of the cell 2010;21(15):2578-88.
2010: Jamel Mankouri; Philip R Tedbury; Sarah Gretton; Mair E Hughes; Stephen Griffin; Mark L Dallas; Kevin A Green; D Grahame Hardie; Chris Peers; Mark Harris
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11549-54.
2010: Simon A Hawley; Fiona A Ross; Cyrille Chevtzoff; Kevin A Green; Ashleigh Evans; Sarah Fogarty; Mhairi C Towler; Laura J Brown; Oluseye A Ogunbayo; A Mark Evans; D Grahame Hardie
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.
Cell metabolism 2010;11(6):554-65.
2010: S Fogarty; D Grahame Hardie
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.
Biochimica et biophysica acta 2010;1804(3):581-91.
2010: Sarah Fogarty; Simon A Hawley; Kevin A Green; Nazan Saner; Kirsty J Mustard; D Grahame Hardie
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
The Biochemical journal 2010;426(1):109-18.
2010: Angela McDonald; Sarah Fogarty; Isabelle Leclerc; Elaine V Hill; D Grahame Hardie; Guy A Rutter
Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.
Biochemical Society transactions 2010;38(Pt 1):205-8.
2010: Silvie Timmers; Johan de Vogel-van den Bosch; Mhairi C Towler; Gert Schaart; Esther Moonen-Kornips; Ronald P Mensink; Matthijs K C Hesselink; D Grahame Hardie; patrick schrauwen
Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.
Journal of lipid research 2010;51(2):352-9.
2009: Angela McDonald; Sarah Fogarty; Isabelle Leclerc; Elaine V Hill; D Grahame Hardie; Guy A Rutter
Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation.
Islets 2009;1(3):198-209.
2009: A Mark Evans; D Grahame Hardie; Chris Peers; Christopher N Wyatt; Benoit Viollet; Prem Kumar; Mark L Dallas; Fiona Ross; Naoko Ikematsu; Heidi L Jordan; Barbara L Barr; J Nicole Rafferty; Oluseye Ogunbayo
Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.
Annals of the New York Academy of Sciences 2009;1177():89-100.
2009: Christian Pehmøller; Jonas T Treebak; Jesper B Birk; Shuai Chen; Carol Mackintosh; D Grahame Hardie; Erik A Richter; Jørgen F P Wojtaszewski
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E665-75.
2009: Jonas T Treebak; Christian Frøsig; C Pehmøller; S Chen; S J Maarbjerg; N Brandt; C MacKintosh; Juleen R Zierath; D Grahame Hardie; Bente Kiens; Erik A Richter; Henriette Pilegaard; Jørgen F P Wojtaszewski
Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.
Diabetologia 2009;52(5):891-900.
2009: A McBride; D Grahame Hardie
AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP?
Acta physiologica (Oxford, England) 2009;196(1):99-113.
2009: Andrew McBride; Stephanos Ghilagaber; Andrei Nikolaev; D Grahame Hardie
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor.
Cell metabolism 2009;9(1):23-34.
2009: Sarah Fogarty; D Grahame Hardie
C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
The Journal of biological chemistry 2009;284(1):77-84.
2009: Mark L Dallas; Jason L Scragg; C N Wyatt; F Ross; D Grahame Hardie; A M Evans; Chris Peers
Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase.
Advances in experimental medicine and biology 2009;648():57-63.
2008: Mhairi C Towler; Sarah Fogarty; Simon A Hawley; David A Pan; David M A Martin; Nick A Morrice; Afshan McCarthy; María N Galardo; Silvina B Meroni; Selva B Cigorraga; Alan Ashworth; Kei Sakamoto; D Grahame Hardie
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
The Biochemical journal 2008;416(1):1-14.
2008: Tom P Robertson; Kirsteen J W Mustard; Tristan H Lewis; Jill H Clark; Christopher N Wyatt; Elisa A Blanco; Chris Peers; D Grahame Hardie; A Mark Evans
AMP-activated protein kinase and hypoxic pulmonary vasoconstriction.
European journal of pharmacology 2008;595(1-3):39-43.
2008: Keith Baar; D Grahame Hardie
Small molecules can have big effects on endurance.
Nature chemical biology 2008;4(10):583-4.
2008: D Grahame Hardie
AMPK: a key regulator of energy balance in the single cell and the whole organism.
International journal of obesity (2005) 2008;32 Suppl 4():S7-12.
2008: D Grahame Hardie
AMPK and Raptor: matching cell growth to energy supply.
Molecular cell 2008;30(3):263-5.
2008: Sean L McGee; Kirsty J Mustard; D Grahame Hardie; Keith Baar
Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice.
The Journal of physiology 2008;586(6):1731-41.
2008: D Grahame Hardie
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
FEBS letters 2008;582(1):81-9.
2008: Christopher N Wyatt; Selina A Pearson; Prem Kumar; Chris Peers; D Grahame Hardie; A Mark Evans
Key roles for AMP-activated protein kinase in the function of the carotid body?
Advances in experimental medicine and biology 2008;605():63-8.
2007: D Grahame Hardie
How I became a biochemist.
IUBMB life 2007;59(12):793-6.
2007: Olga Göransson; Andrew McBride; Simon A Hawley; Fiona A Ross; Natalia Shpiro; Marc Foretz; Benoit Viollet; D Grahame Hardie; Kei Sakamoto
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
The Journal of biological chemistry 2007;282(45):32549-60.
2007: Valentina Pallottini; Chiara Martini; Gabriella Cavallini; Ettore Bergamini; Kirsty J Mustard; D Grahame Hardie; Anna Trentalance
Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation.
Mechanisms of ageing and development 2007;128(11-12):688-95.
2007: D Grahame Hardie
AMPK and SNF1: Snuffing Out Stress.
Cell metabolism 2007;6(5):339-40.
2007: Merete Ekmark; Zaheer Rana; Greg Stewart; D Grahame Hardie; Kristian Gundersen
De-phosphorylation of MyoD is linking nerve-evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle.
The Journal of physiology 2007;584(Pt 2):637-50.
2007: Kathryn M Geraghty; Shuai Chen; Jean E Harthill; Adel F M Ibrahim; Rachel Toth; Nick A Morrice; Franck VANDERMOERE; Greg B G Moorhead; D Grahame Hardie; Carol MacKintosh
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.
The Biochemical journal 2007;407(2):231-41.
2007: D Grahame Hardie
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Nature reviews. Molecular cell biology 2007;8(10):774-85.
2007: Hasan O Akman; James N Sampayo; Fiona A Ross; John W Scott; Gregory Wilson; Lee Benson; Claudio Bruno; Sara Shanske; D Grahame Hardie; Salvatore DiMauro
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.
Pediatric research 2007;62(4):499-504.
2007: Alison M Woollhead; J Sivagnanasundaram; K K Kalsi; Vladimir Pucovsky; L J Pellatt; J W Scott; K J Mustard; D Grahame Hardie; Deborah L Baines
Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.
British journal of pharmacology 2007;151(8):1204-15.
2007: Daniel J Cuthbertson; John A Babraj; Kirsty J Mustard; Mhairi C Towler; Kevin A Green; Henning Wackerhage; Graham P Leese; Keith Baar; Michaela Thomason-Hughes; Calum Sutherland; D Grahame Hardie; Michael John Rennie
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.
Diabetes 2007;56(8):2078-84.
2007: Rosa Viana; Mhairi C Towler; David A Pan; David Carling; Benoit Viollet; D Grahame Hardie; Pascual Sanz
A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.
The Journal of biological chemistry 2007;282(22):16117-25.
2007: D Grahame Hardie
Biochemistry. Balancing cellular energy.
Science (New York, N.Y.) 2007;315(5819):1671-2.
2007: James A Reihill; Marie-Ann Ewart; D Grahame Hardie; Ian P Salt
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
Biochemical and biophysical research communications 2007;354(4):1084-8.
2007: Christopher N Wyatt; Kirsty J Mustard; Selina A Pearson; Mark L Dallas; Lucy Atkinson; Prem Kumar; Chris Peers; D Grahame Hardie; A Mark Evans
AMP-activated protein kinase mediates carotid body excitation by hypoxia.
The Journal of biological chemistry 2007;282(11):8092-8.
2007: Mhairi C Towler; D Grahame Hardie
AMP-activated protein kinase in metabolic control and insulin signaling.
Circulation research 2007;100(3):328-41.
2007: John W Scott; Fiona A Ross; J K David Liu; D Grahame Hardie
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.
The EMBO journal 2007;26(3):806-15.
2007: Richard M Reznick; Haihong Zong; Li Ji; Katsutaro Morino; Irene K Moore; Hannah J Yu; Zhen-Xiang Liu; Jianying Dong; Kirsty J Mustard; Simon A Hawley; Douglas Befroy; Marc Pypaert; D Grahame Hardie; Lawrence H Young; Gerald I Shulman
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
Cell metabolism 2007;5(2):151-6.
2007: D Grahame Hardie; Bruno G Frenguelli
A neural protection racket: AMPK and the GABA(B) receptor.
Neuron 2007;53(2):159-62.
2007: D Grahame Hardie
AMP-activated protein kinase as a drug target.
Annual review of pharmacology and toxicology 2007;47():185-210.
2006: Henriette Pilegaard; Jesper B Birk; Massimo Sacchetti; Marina Mourtzakis; D Grahame Hardie; Greg Stewart; P Darrell Neufer; Bengt Saltin; Gerrit van Hall; Jørgen F P Wojtaszewski
PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.
Diabetes 2006;55(11):3020-7.
2006: Carsten Roepstorff; Morten Donsmark; Maja Thiele; Bodil Vistisen; Greg Stewart; Kristian Vissing; Peter Schjerling; D Grahame Hardie; Henrik Galbo; Bente Kiens
Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise.
American journal of physiology. Endocrinology and metabolism 2006;291(5):E1106-14.
2006: Peter Tamás; Simon A Hawley; Rosemary G Clarke; Kirsty J Mustard; Kevin Green; D Grahame Hardie; Doreen A Cantrell
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.
The Journal of experimental medicine 2006;203(7):1665-70.
2006: D Grahame Hardie; Simon A Hawley; John W Scott
AMP-activated protein kinase--development of the energy sensor concept.
The Journal of physiology 2006;574(Pt 1):7-15.
2006: Jing Chen; Emma Hudson; Maggie M-Y Chi; Aimee S Chang; Kelle H Moley; D Grahame Hardie; Stephen M Downs
AMPK regulation of mouse oocyte meiotic resumption in vitro.
Developmental biology 2006;291(2):227-38.
2006: D Grahame Hardie; Kei Sakamoto
AMPK: a key sensor of fuel and energy status in skeletal muscle.
Physiology (Bethesda, Md.) 2006;21():48-60.
2006: A Mark Evans; D Grahame Hardie; Antony Galione; Chris Peers; Prem Kumar; Christopher N Wyatt
AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.
Novartis Foundation symposium 2006;272():234-52; discussion 252-8, 274-9.
2006: Christopher N Wyatt; Prem Kumar; Parvinder Aley; Chris Peers; D Grahame Hardie; A Mark Evans
Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?
Advances in experimental medicine and biology 2006;580():191-6; discussion 351-9.
2006: A Mark Evans; Kirsty J Mustard; Christopher N Wyatt; Michelle Dipp; Nicholas P Kinnear; D Grahame Hardie
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction?
Advances in experimental medicine and biology 2006;580():147-54; discussion 351-9.
2005: A Mark Evans; Kirsty J Mustard; Christopher N Wyatt; Chris Peers; Michelle Dipp; Prem Kumar; Nicholas P Kinnear; D Grahame Hardie
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?
The Journal of biological chemistry 2005;280(50):41504-11.
2005: Vera B Schrauwen-Hinderling; M Eline Kooi; Matthijs K C Hesselink; Esther Moonen-Kornips; Gert Schaart; Kirsty J Mustard; D Grahame Hardie; Wim H M Saris; Klaas Nicolay; patrick schrauwen
Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet.
Obesity research 2005;13(12):2088-94.
2005: Jana Sponarova; Kirsty J Mustard; Olga Horakova; Pavel Flachs; Martin Rossmeisl; Petr Brauner; Kristina Bardova; Michaela Thomason-Hughes; Radka Braunerova; Petra Janovska; D Grahame Hardie; Jan Kopecky
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation.
FEBS letters 2005;579(27):6105-10.
2005: Luc van Loon; Michaela Thomason-Hughes; Dumitru Constantin-Teodosiu; René Koopman; Paul L Greenhaff; D Grahame Hardie; Hans A Keizer; Wim H M Saris; Anton J M Wagenmakers
Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E482-93.
2005: Alison M Woollhead; John W Scott; D Grahame Hardie; Deborah L Baines
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.
The Journal of physiology 2005;566(Pt 3):781-92.
2005: Simon A Hawley; David A Pan; Kirsty J Mustard; Louise Ross; Jenny Bain; Arthur M Edelman; Bruno G Frenguelli; D Grahame Hardie
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Cell metabolism 2005;2(1):9-19.
2005: Blerina Kola; Erika Hubina; Sonia A Tucci; Tim C Kirkham; Edwin A Garcia; Sharon E Mitchell; Lynda M Williams; Simon A Hawley; D Grahame Hardie; Ashley B Grossman; Marta Korbonits
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.
The Journal of biological chemistry 2005;280(26):25196-201.
2005: Clara Prats; Joan Cadefau; Roser Cussó; Klaus Qvortrup; Jakob N Nielsen; Jørgen F P Wojtaszewski; Jørgen F P Wojtaszewki; D Grahame Hardie; Greg Stewart; Bo F Hansen; Thorkil Ploug
Phosphorylation-dependent translocation of glycogen synthase to a novel structure during glycogen resynthesis.
The Journal of biological chemistry 2005;280(24):23165-72.
2005: D Grahame Hardie
New roles for the LKB1-->AMPK pathway.
Current opinion in cell biology 2005;17(2):167-73.
2005: Agnieszka Dobrzyn; Pawel Dobrzyn; Seong-Ho Lee; Makoto Miyazaki; Paul Cohen; Esra Asilmaz; D Grahame Hardie; Jeffrey M Friedman; James M Ntambi
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2005;288(3):E599-607.
2005: Franck Rencurel; Alasdair Stenhouse; Simon A Hawley; Thomas Friedberg; D Grahame Hardie; Calum Sutherland; C Roland Wolf
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
The Journal of biological chemistry 2005;280(6):4367-73.
2005: Kanchana Dokladda; Kevin A Green; David A Pan; D Grahame Hardie
PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway.
FEBS letters 2005;579(1):236-40.
2005: Barbara B Kahn; Thierry Alquier; David Carling; D Grahame Hardie
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Cell metabolism 2005;1(1):15-25.
2004: Jérôme Boudeau; John W Scott; Nicoletta Resta; Maria Deak; Agnieszka Kieloch; David Komander; D Grahame Hardie; Alan R Prescott; Daan M F van Aalten; Dario R Alessi
Analysis of the LKB1-STRAD-MO25 complex.
Journal of cell science 2004;117(Pt 26):6365-75.
2004: Sebastian B Jørgensen; Jakob N Nielsen; Jesper B Birk; Grith S Olsen; Benoit Viollet; Fabrizio Andreelli; Peter Schjerling; Sophie Vaulont; D Grahame Hardie; Bo F Hansen; Erik A Richter; Jørgen F P Wojtaszewski
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.
Diabetes 2004;53(12):3074-81.
2004: D Grahame Hardie
The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal of cell science 2004;117(Pt 23):5479-87.
2004: Carsten Roepstorff; Bodil Vistisen; Morten Donsmark; Jakob N Nielsen; Henrik Galbo; Kevin A Green; D Grahame Hardie; Jørgen F P Wojtaszewski; Erik A Richter; Bente Kiens
Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise.
The Journal of physiology 2004;560(Pt 2):551-62.
2004: Anna Kelner; Izabela Pekala; Szymon Kaczanowski; Grazyna Muszynska; D Grahame Hardie; Grazyna Dobrowolska
Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress.
Plant physiology 2004;136(2):3255-65.
2004: D Grahame Hardie
AMP-activated protein kinase: the guardian of cardiac energy status.
The Journal of clinical investigation 2004;114(4):465-8.
2004: Kei Sakamoto; Olga Göransson; D Grahame Hardie; Dario R Alessi
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E310-7.
2004: patrick schrauwen; D Grahame Hardie; B Roorda; John Clapham; Alejandro Abuin; Michaela Thomason-Hughes; K Green; Peter M Frederik; Matthijs K C Hesselink
Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(6):824-8.
2004: D Grahame Hardie
AMP-activated protein kinase: a master switch in glucose and lipid metabolism.
Reviews in endocrine & metabolic disorders 2004;5(2):119-25.
2004: Pawel Dobrzyn; Agnieszka Dobrzyn; Makoto Miyazaki; Paul Cohen; Esra Asilmaz; D Grahame Hardie; Jeffrey M Friedman; James M Ntambi
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6409-14.
2004: Anne E Gadalla; Tim Pearson; Ailsa J Currie; Nicholas Dale; Simon A Hawley; Mike Sheehan; Warren Hirst; Anton D Michel; Andrew Randall; D Grahame Hardie; Bruno G Frenguelli
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.
Journal of neurochemistry 2004;88(5):1272-82.
2004: Christian Frøsig; Sebastian B Jørgensen; D Grahame Hardie; Erik A Richter; Jørgen F P Wojtaszewski
5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2004;286(3):E411-7.
2004: Jose Lizcano; Olga Göransson; Rachel Toth; Maria Deak; Nick A Morrice; Jérôme Boudeau; Simon A Hawley; Lina Udd; Tomi Mäkelä; D Grahame Hardie; Dario R Alessi
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
The EMBO journal 2004;23(4):833-43.
2004: Stephen P Slocombe; Frédéric Beaudoin; Paul G Donaghy; D Grahame Hardie; J Richard Dickinson; Nigel G Halford
SNF1-related protein kinase (snRK1) phosphorylates class I heat shock protein.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale 2004;42(2):111-6.
2004: Kurt Højlund; Kirsty J Mustard; Peter Staehr; D Grahame Hardie; Henning Beck-Nielsen; Erik A Richter; Jørgen F P Wojtaszewski
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2004;286(2):E239-44.
2004: John W Scott; Simon A Hawley; Kevin A Green; Miliea Anis; Greg Stewart; Gillian A Scullion; David G Norman; D Grahame Hardie
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
The Journal of clinical investigation 2004;113(2):274-84.
2004: D Grahame Hardie
AMP-activated protein kinase: a key system mediating metabolic responses to exercise.
Medicine and science in sports and exercise 2004;36(1):28-34.
2003: D Grahame Hardie
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.
Endocrinology 2003;144(12):5179-83.
2003: David L Coven; Xiaoyue Hu; Lin Cong; Raynald Bergeron; Gerald I Shulman; D Grahame Hardie; Lawrence H Young
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E629-36.
2003: Catherine M Sutherland; Simon A Hawley; Rhonda R McCartney; Anna Leech; Michael J R Stark; Martin C Schmidt; D Grahame Hardie
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.
Current biology : CB 2003;13(15):1299-305.
2003: D Grahame Hardie; John W Scott; David A Pan; Emma R Hudson
Management of cellular energy by the AMP-activated protein kinase system.
FEBS letters 2003;546(1):113-20.
2003: Kurt Højlund; Peter Staehr; Bo Falck Hansen; Kevin A Green; D Grahame Hardie; Erik A Richter; Henning Beck-Nielsen; Jørgen F P Wojtaszewski
Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes.
Diabetes 2003;52(6):1393-402.
2003: Emma R Hudson; David A Pan; John James; John M Lucocq; Simon A Hawley; Kevin A Green; Otto Baba; Tatsuo Terashima; D Grahame Hardie
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.
Current biology : CB 2003;13(10):861-6.
2003: Jørgen F P Wojtaszewski; Christopher MacDonald; Jakob N Nielsen; Ylva Hellsten; D Grahame Hardie; Bruce E Kemp; Bente Kiens; Erik A Richter
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E813-22.
2003: William W Winder; D Grahame Hardie; Kirsty J Mustard; Lyle J Greenwood; B E Paxton; SH Park; DS Rubink; Eric B Taylor
Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle.
Biochemical Society transactions 2003;31(Pt 1):182-5.
2003: Jakob N Nielsen; Kirsty J W Mustard; Drew A Graham; Haiyan Yu; Christopher S MacDonald; Henriette Pilegaard; Laurie J Goodyear; D Grahame Hardie; Erik A Richter; Jørgen F P Wojtaszewski
5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(2):631-41.
2003: Simon A Hawley; Jérôme Boudeau; Jennifer L Reid; Kirsty J Mustard; Lina Udd; Tomi Mäkelä; Dario R Alessi; D Grahame Hardie
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Journal of biology 2003;2(4):28.
2002: SH Park; SR Paulsen; S R Gammon; Kirsty J Mustard; D Grahame Hardie; William W Winder
Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(6):2081-8.
2002: D Grahame Hardie; David A Pan
Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase.
Biochemical Society transactions 2002;30(Pt 6):1064-70.
2002: David A Pan; D Grahame Hardie
A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion.
The Biochemical journal 2002;367(Pt 1):179-86.
2002: Simon A Hawley; Anne E Gadalla; Grith S Olsen; D Grahame Hardie
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.
Diabetes 2002;51(8):2420-5.
2002: Paula E Durante; Kirsty J Mustard; Soo-Hyun Park; William W Winder; D Grahame Hardie
Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E178-86.
2002: Jakob N Nielsen; Jørgen F P Wojtaszewski; Ronald G Haller; D Grahame Hardie; Bruce E Kemp; Erik A Richter; John Vissing
Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease.
The Journal of physiology 2002;541(Pt 3):979-89.
2002: Kay Barnes; Jean C Ingram; Omar H Porras; Luis Felipe Barros; Emma R Hudson; Lee G D Fryer; Fabienne Foufelle; David Carling; D Grahame Hardie; Stephen A Baldwin
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).
Journal of cell science 2002;115(Pt 11):2433-42.
2002: Hua Ai; Jacob Ihlemann; Ylva Hellsten; Hans P M M Lauritzen; D Grahame Hardie; Henrik Galbo; Thorkil Ploug
Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1291-300.
2002: Wengong Wang; JINSHUI FAN; Xiaoling Yang; Stefanie Fürer-Galban; Isabel Lopez de Silanes; Cayetano von Kobbe; Jia Guo; Steve N Georas; Fabienne Foufelle; D Grahame Hardie; David Carling; Myriam Gorospe
AMP-activated kinase regulates cytoplasmic HuR.
Molecular and cellular biology 2002;22(10):3425-36.
2002: Stephen M Downs; Emma R Hudson; D Grahame Hardie
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes.
Developmental biology 2002;245(1):200-12.
2002: John W Scott; David G Norman; Simon A Hawley; Luke Kontogiannis; D Grahame Hardie
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate.
Journal of molecular biology 2002;317(2):309-23.
2002: Jørgen F P Wojtaszewski; Sebastian B Jørgensen; Ylva Hellsten; D Grahame Hardie; Erik A Richter
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.
Diabetes 2002;51(2):284-92.
2001: Russell M Crawford; Nigel G Halford; D Grahame Hardie
Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-alpha1), and immunological analysis of multiple forms of the kinase, in spinach leaf.
Plant molecular biology 2001;45(6):731-41.
2000: Lee G D Fryer; Eric Hajduch; F Rencurel; IP Salt; Harinder S Hundal; D Grahame Hardie; David Carling
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
Diabetes 2000;49(12):1978-85.
2000: Pamela A Lochhead; IP Salt; KS Walker; D Grahame Hardie; Calum Sutherland
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Diabetes 2000;49(6):896-903.
2000: PC Cheung; IP Salt; SP Davies; D Grahame Hardie; David Carling
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
The Biochemical journal 2000;346 Pt 3():659-69.
2000: D Grahame Hardie
Peptide assay of protein kinases and use of variant peptides to determine recognition motifs.
Methods in molecular biology (Clifton, N.J.) 2000;99():191-201.
2000: D Grahame Hardie; IP Salt; SP Davies
Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.
Methods in molecular biology (Clifton, N.J.) 2000;99():63-74.
1999: C Sugden; Russell M Crawford; Nigel G Halford; D Grahame Hardie
Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP.
The Plant journal : for cell and molecular biology 1999;19(4):433-9.
1999: William W Winder; D Grahame Hardie
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.
The American journal of physiology 1999;277(1 Pt 1):E1-10.
1999: F C Smith; SP Davies; W A Wilson; David Carling; D Grahame Hardie
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1.
FEBS letters 1999;453(1-2):219-23.
1999: C Sugden; P G Donaghy; Nigel G Halford; D Grahame Hardie
Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro.
Plant physiology 1999;120(1):257-74.
1999: D Grahame Hardie; IP Salt; Simon A Hawley; SP Davies
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.
The Biochemical journal 1999;338 ( Pt 3)():717-22.
1998: IP Salt; G Johnson; S J Ashcroft; D Grahame Hardie
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
The Biochemical journal 1998;335 ( Pt 3)():533-9.
1998: IP Salt; J W Celler; Simon A Hawley; Alan R Prescott; A Woods; D Carling; D Grahame Hardie
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.
The Biochemical journal 1998;334 ( Pt 1)():177-87.
1997: D Grahame Hardie; J Corton; Y P Ching; SP Davies; Simon A Hawley
Regulation of lipid metabolism by the AMP-activated protein kinase.
Biochemical Society transactions 1997;25(4):1229-31.
1997: Y P Ching; T Kobayashi; S Tamura; D Grahame Hardie
Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase.
FEBS letters 1997;411(2-3):265-8.
1997: D Grahame Hardie; David Carling
The AMP-activated protein kinase--fuel gauge of the mammalian cell?
European journal of biochemistry / FEBS 1997;246(2):259-73.
1997: A B Sprenkle; SP Davies; David Carling; D Grahame Hardie; Thomas W Sturgill
Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.
FEBS letters 1997;403(3):254-8.
1997: CA Hutber; D Grahame Hardie; William W Winder
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase.
The American journal of physiology 1997;272(2 Pt 1):E262-6.
1997: William W Winder; HA Wilson; D Grahame Hardie; BB Rasmussen; CA Hutber; GB Call; R D Clayton; L M Conley; S Yoon; B Zhou
Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(1):219-25.
1996: A Woods; IP Salt; J Scott; D Grahame Hardie; David Carling
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro.
FEBS letters 1996;397(2-3):347-51.
1996: W A Wilson; S A Hawley; D Grahame Hardie
Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio.
Current biology : CB 1996;6(11):1426-34.
1996: J H Barker; S P Slocombe; Kathryn L Ball; D Grahame Hardie; Peter R Shewry; Nigel G Halford
Evidence that barley 3-hydroxy-3-methylglutaryl-coenzyme a reductase kinase is a member of the sucrose nonfermenting-1-related protein kinase family.
Plant physiology 1996;112(3):1141-9.
1996: Simon A Hawley; M Davison; A Woods; SP Davies; R K Beri; David Carling; D Grahame Hardie
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase.
The Journal of biological chemistry 1996;271(44):27879-87.
1996: Y P Ching; SP Davies; D Grahame Hardie
Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method.
European journal of biochemistry / FEBS 1996;237(3):800-8.
1996: William W Winder; D Grahame Hardie
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.
The American journal of physiology 1996;270(2 Pt 1):E299-304.
1996: J M Corton; D Grahame Hardie
Regulation of lipid biosynthesis by the AMP-activated protein kinase and its role in the hepatocellular response to stress.
Progress in liver diseases 1996;14():69-99.
1995: SP Davies; Nicholas R Helps; Patricia T W Cohen; D Grahame Hardie
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.
FEBS letters 1995;377(3):421-5.
1995: Kathryn L Ball; J Barker; Nigel G Halford; D Grahame Hardie
Immunological evidence that HMG-CoA reductase kinase-A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases.
FEBS letters 1995;377(2):189-92.
1995: Simon A Hawley; M A Selbert; E G Goldstein; Arthur M Edelman; David Carling; D Grahame Hardie
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.
The Journal of biological chemistry 1995;270(45):27186-91.
1995: S Dale; M Arró; B Becerra; Nick Morrice; Albert Boronat; D Grahame Hardie; Albert Ferrer
Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase.
European journal of biochemistry / FEBS 1995;233(2):506-13.
1995: J M Corton; J G Gillespie; Simon A Hawley; D Grahame Hardie
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
European journal of biochemistry / FEBS 1995;229(2):558-65.
1995: S Dale; W A Wilson; A M Edelman; D Grahame Hardie
Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I.
FEBS letters 1995;361(2-3):191-5.
1995: A J Verhoeven; A Woods; C H Brennan; Simon A Hawley; D Grahame Hardie; James Scott; R K Beri; David Carling
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA.
European journal of biochemistry / FEBS 1995;228(2):236-43.
1994: D Grahame Hardie; David Carling; Nigel G Halford
Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.
Seminars in cell biology 1994;5(6):409-16.
1994: SP Davies; Simon A Hawley; A Woods; David Carling; T A Haystead; D Grahame Hardie
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.
European journal of biochemistry / FEBS 1994;223(2):351-7.
1994: J M Corton; J G Gillespie; D Grahame Hardie
Role of the AMP-activated protein kinase in the cellular stress response.
Current biology : CB 1994;4(4):315-24.
1994: J Weekes; Simon A Hawley; J Corton; D Shugar; D Grahame Hardie
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.
European journal of biochemistry / FEBS 1994;219(3):751-7.
1994: Kathryn L Ball; S Dale; J Weekes; D Grahame Hardie
Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia).
European journal of biochemistry / FEBS 1994;219(3):743-50.
1993: J Weekes; Kathryn L Ball; F B Caudwell; D Grahame Hardie
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.
FEBS letters 1993;334(3):335-9.
1992: R W Mackintosh; SP Davies; Paul Clarke; J Weekes; J G Gillespie; B J Gibb; D Grahame Hardie
Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase.
European journal of biochemistry / FEBS 1992;209(3):923-31.
1992: D Grahame Hardie; R W MacKintosh
AMP-activated protein kinase--an archetypal protein kinase cascade?
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(10):699-704.
1992: J G Gillespie; D Grahame Hardie
Phosphorylation and inactivation of HMG-CoA reductase at the AMP-activated protein kinase site in response to fructose treatment of isolated rat hepatocytes.
FEBS letters 1992;306(1):59-62.
1992: J M Corton; D Grahame Hardie
Evidence against a role for phosphorylation/dephosphorylation in the regulation of acyl-CoA:cholesterol acyl transferase.
European journal of biochemistry / FEBS 1992;204(1):203-8.
1992: D Grahame Hardie
Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase.
Biochimica et biophysica acta 1992;1123(3):231-8.
1992: SP Davies; David Carling; M R Munday; D Grahame Hardie
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets.
European journal of biochemistry / FEBS 1992;203(3):615-23.
1991: D Grahame Hardie
Reactin' with activin.
Current biology : CB 1991;1(5):321-2.
1991: Philip Cohen; D Grahame Hardie
The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1991;1094(3):292-9.
1991: F Moore; J Weekes; D Grahame Hardie
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion.
European journal of biochemistry / FEBS 1991;199(3):691-7.
1991: David Carling; Paul Clarke; D Grahame Hardie
Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.
Methods in enzymology 1991;200():362-71.
1991: D Grahame Hardie; T A Haystead; A T Sim
Use of okadaic acid to inhibit protein phosphatases in intact cells.
Methods in enzymology 1991;201():469-76.
1990: R W MacKintosh; G Haycox; D Grahame Hardie; Patricia T W Cohen
Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases-1 and -2A.
FEBS letters 1990;276(1-2):156-60.
1990: Paul Clarke; D Grahame Hardie
Calmodulin-dependent multiprotein kinase and protein kinase C phosphorylate the same site on HMG-CoA reductase as the AMP-activated protein kinase.
FEBS letters 1990;269(1):213-7.
1990: Paul Clarke; D Grahame Hardie
Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
The EMBO journal 1990;9(8):2439-46.
1990: SP Davies; A T Sim; D Grahame Hardie
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase.
European journal of biochemistry / FEBS 1990;187(1):183-90.
1990: T A Haystead; F Moore; Philip Cohen; D Grahame Hardie
Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes.
European journal of biochemistry / FEBS 1990;187(1):199-205.
1990: D Grahame Hardie
Roles of protein kinases and phosphatases in signal transduction.
Symposia of the Society for Experimental Biology 1990;44():241-55.
1989: David Carling; Paul Clarke; V A Zammit; D Grahame Hardie
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.
European journal of biochemistry / FEBS 1989;186(1-2):129-36.
1989: SP Davies; David Carling; D Grahame Hardie
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay.
European journal of biochemistry / FEBS 1989;186(1-2):123-8.
1989: David Carling; D Grahame Hardie
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase.
Biochimica et biophysica acta 1989;1012(1):81-6.
1989: T A Haystead; A T Sim; David Carling; R C Honnor; Y Tsukitani; Philip Cohen; D Grahame Hardie
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
Nature 1989;337(6202):78-81.
1989: D Grahame Hardie
Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase.
Progress in lipid research 1989;28(2):117-46.
1988: M R Munday; David Carling; D Grahame Hardie
Negative interactions between phosphorylation of acetyl-CoA carboxylase by the cyclic AMP-dependent and AMP-activated protein kinases.
FEBS letters 1988;235(1-2):144-8.
1988: M R Munday; D G Campbell; David Carling; D Grahame Hardie
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.
European journal of biochemistry / FEBS 1988;175(2):331-8.
1988: A T Sim; D Grahame Hardie
The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase.
FEBS letters 1988;233(2):294-8.
1988: E A Carrey; D Grahame Hardie
Mapping of catalytic domains and phosphorylation sites in the multifunctional pyrimidine-biosynthetic protein CAD.
European journal of biochemistry / FEBS 1988;171(3):583-8.
1987: David Carling; V A Zammit; D Grahame Hardie
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.
FEBS letters 1987;223(2):217-22.