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Steven Leeder

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Carrie A Vyhlidal; Scott T Weiss; Hongying Dai; Kathleen J Haley; Amanda K Riffel; Sunita Sharma; Kelan G Tantisira; J Steven Leeder
Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Jonathan Wagner; J Steven Leeder
Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
J Steven Leeder; Gregory L Kearns
Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.

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All Publications

2013: Carrie A Vyhlidal; Scott T Weiss; Hongying Dai; Kathleen J Haley; Amanda K Riffel; Sunita Sharma; Kelan G Tantisira; J Steven Leeder
Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(2):305-11.
2012: Jonathan Wagner; J Steven Leeder
Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Pediatric clinics of North America 2012;59(5):1017-37.
2012: J Steven Leeder; Gregory L Kearns
Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Clinical pharmacology and therapeutics 2012;92(4):434-6.
2012: Leon van Haandel; Todd D Williams; Mara L Becker; John F Stobaugh; J Steven Leeder
Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2012;26(14):1617-30.
2011: Jennifer Goldman; Bridgette Jones; Mara L Becker; Mark Clements; J Steven Leeder
Development of biomarkers to optimize pediatric patient management: what makes children different?
Biomarkers in medicine 2011;5(6):781-94.
2011: K E Price; R E Pearce; U C Garg; B A Heese; L D Smith; J E Sullivan; M J Kennedy; J F Bale; R M Ward; T K H Chang; F S Abbott; J Steven Leeder
Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Clinical pharmacology and therapeutics 2011;89(6):867-74.
2011: Parvaz Madadi; Catherine Ciszkowski; Andrea Gaedigk; J Steven Leeder; Ronni Teitelbaum; David Chitayat; Gideon Koren
Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Current drug safety 2011;6(1):36-9.
2010: Joshua E Petrikin; Roger Gaedigk; J Steven Leeder; William E Truog
Selective Toll--like receptor expression in human fetal lung.
Pediatric research 2010;68(4):335-8.
2010: Andrea Gaedigk; Roger Gaedigk; J Steven Leeder
UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2010;48(5):627-33.
2010: Mara L Becker; J Steven Leeder
Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Human genomics and proteomics : HGP 2010;2010():257120.
2010: Susan M Abdel-Rahman; Takashi Sugita; Gloria M González; David Ellis; Michalis Arabatzis; Loranne Vella-Zahra; Calude Viguié-Vallanet; Masataro Hiruma; J Steven Leeder; Barry Preuett
Divergence among an international population of Trichophyton tonsurans isolates.
Mycopathologia 2010;169(1):1-13.
2009: J Steven Leeder
Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Clinical pharmacology and therapeutics 2009;86(6):678-82.
2008: Robin E Pearce; Wei Lu; Yongqiang Wang; Jack P Uetrecht; Maria Almira Correia; J Steven Leeder
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1637-49.
2008: Ping Kang; Mingxiang Liao; Michael R Wester; J Steven Leeder; Robin E Pearce; Maria Almira Correia
CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(3):490-9.
2008: Andrea Gaedigk; S D Simon; Robin E Pearce; Dianne L Bradford; M J Kennedy; J Steven Leeder
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Clinical pharmacology and therapeutics 2008;83(2):234-42.
2008: Chengpeng Bi; J Steven Leeder; Carrie A Vyhlidal
A comparative study on computational two-block motif detection: algorithms and applications.
Molecular pharmaceutics 2008;5(1):3-16.
2007: Andrea Gaedigk; J D Eklund; Robin E Pearce; J Steven Leeder; Sarah W Alander; Michael S Phillips; Dianne L Bradford; M J Kennedy
Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Clinical pharmacology and therapeutics 2007;81(6):817-20.
2007: Michael J Blake; Andrea Gaedigk; Robin E Pearce; L R Bomgaars; M L Christensen; Cindy D Stowe; Laura P James; John T Wilson; Gregory L Kearns; J Steven Leeder
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
Clinical pharmacology and therapeutics 2007;81(4):510-6.
2006: Michael J Blake; Susan M Abdel-Rahman; Robin E Pearce; J Steven Leeder; Gregory L Kearns
Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Pediatric research 2006;60(6):717-23.
2006: Andrea Gaedigk; Darren W Baker; Rheem A Totah; Roger Gaedigk; Robin E Pearce; Carrie A Vyhlidal; Darryl C Zeldin; J Steven Leeder
Variability of CYP2J2 expression in human fetal tissues.
The Journal of pharmacology and experimental therapeutics 2006;319(2):523-32.
2006: Robin E Pearce; J Steven Leeder; Gregory L Kearns
Biotransformation of fluticasone: in vitro characterization.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(6):1035-40.
2006: Andrea Gaedigk; Dianne L Bradford; Sarah W Alander; J Steven Leeder
CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):563-9.
2006: Carrie A Vyhlidal; Roger Gaedigk; J Steven Leeder
Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(1):131-7.
2005: Robin E Pearce; Jack P Uetrecht; J Steven Leeder
Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1819-26.
2005: Andrea Gaedigk; Roger Gaedigk; J Steven Leeder
CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Biochemical and biophysical research communications 2005;336(4):1241-50.
2005: J Steven Leeder; Roger Gaedigk; Kenda A Marcucci; Andrea Gaedigk; Carrie A Vyhlidal; Bradley P Schindel; Robin E Pearce
Variability of CYP3A7 expression in human fetal liver.
The Journal of pharmacology and experimental therapeutics 2005;314(2):626-35.
2005: Michael J Blake; Lisa Castro; J Steven Leeder; Gregory L Kearns
Ontogeny of drug metabolizing enzymes in the neonate.
Seminars in fetal & neonatal medicine 2005;10(2):123-38.
2005: Andrea Gaedigk; Liliane Ndjountché; J Steven Leeder; Dianne L Bradford
Limited association of the 2988g > a single nucleotide polymorphism with CYP2D641 in black subjects.
Clinical pharmacology and therapeutics 2005;77(3):228-30; author reply 230-1.
2005: Andrea Gaedigk; A Bhathena; Liliane Ndjountché; Robin E Pearce; Susan M Abdel-Rahman; Sarah W Alander; Dianne L Bradford; Peter K Rogan; J Steven Leeder
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
The pharmacogenomics journal 2005;5(3):173-82.
2004: Issam Zineh; Amber L Beitelshees; Andrea Gaedigk; Joseph R Walker; Daniel F Pauly; Kathleen Eberst; J Steven Leeder; Michael S Phillips; Craig A Gelfand; Julie A Johnson
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Clinical pharmacology and therapeutics 2004;76(6):536-44.
2004: Carrie A Vyhlidal; Peter K Rogan; J Steven Leeder
Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
The Journal of biological chemistry 2004;279(45):46779-86.
2004: J Steven Leeder
Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Drug discovery today 2004;9(13):567-73.
2004: Mary Jayne Kennedy; Susan M Abdel-Rahman; Angela D M Kashuba; J Steven Leeder
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Journal of clinical pharmacology 2004;44(7):708-14.
2003: Gregory L Kearns; Susan M Abdel-Rahman; Sarah W Alander; Douglas L Blowey; J Steven Leeder; Ralph E Kauffman
Developmental pharmacology--drug disposition, action, and therapy in infants and children.
The New England journal of medicine 2003;349(12):1157-67.
2003: Sashidhar Gadiraju; Carrie A Vyhlidal; J Steven Leeder; Peter K Rogan
Genome-wide prediction, display and refinement of binding sites with information theory-based models.
BMC bioinformatics 2003;4():38.
2003: Andrea Gaedigk; Liliane Ndjountché; Roger Gaedigk; J Steven Leeder; Dianne L Bradford
Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.
Clinical pharmacology and therapeutics 2003;73(6):575-6.
2003: Andrea Gaedigk; Darren L Ryder; Dianne L Bradford; J Steven Leeder
CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.
Clinical chemistry 2003;49(6 Pt 1):1008-11.
2003: J Steven Leeder
Developmental and pediatric pharmacogenomics.
Pharmacogenomics 2003;4(3):331-41.
2003: Peter K Rogan; Stan Svojanovsky; J Steven Leeder
Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Pharmacogenetics 2003;13(4):207-18.
2003: Jennifer A Lowry; Gregory L Kearns; Susan M Abdel-Rahman; Anne N Nafziger; Irim S Khan; Angela D M Kashuba; Erin G Schuetz; Joseph S Bertino; John N van den Anker; J Steven Leeder
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Clinical pharmacology and therapeutics 2003;73(3):209-22.
2002: Robin E Pearce; Gangadhara R Vakkalagadda; J Steven Leeder
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(11):1170-9.
2002: Andrea Gaedigk; Dianne L Bradford; Kenda A Marcucci; J Steven Leeder
Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Clinical pharmacology and therapeutics 2002;72(1):76-89.
2002: Kenda A Marcucci; Robin E Pearce; Charles L Crespi; Dorothy T Steimel; J Steven Leeder; Andrea Gaedigk
Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(5):595-601.
2002: J Steven Leeder; G L Kearns
The challenges of delivering pharmacogenomics into clinical pediatrics.
The pharmacogenomics journal 2002;2(3):141-3.
2002: Susan M Abdel-Rahman; J Steven Leeder; J T Wilson; Andrea Gaedigk; RR Gotschall; R Medve; S Liao; SP Spielberg; Gregory L Kearns
Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation.
Journal of clinical pharmacology 2002;42(1):24-9.
2001: Robin E Pearce; RR Gotschall; Gregory L Kearns; J Steven Leeder
Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(12):1548-54.
2001: Andrea Gaedigk; WL Casley; R F Tyndale; E M Sellers; M Jurima-Romet; J Steven Leeder
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Canadian journal of physiology and pharmacology 2001;79(10):841-7.
2001: J Steven Leeder
Pharmacogenetics and pharmacogenomics.
Pediatric clinics of North America 2001;48(3):765-81.
1999: Andrea Gaedigk; RR Gotschall; N S Forbes; S D Simon; Gregory L Kearns; J Steven Leeder
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Pharmacogenetics 1999;9(6):669-82.
1999: Susan M Abdel-Rahman; Kenda A Marcucci; T Boge; RR Gotschall; Gregory L Kearns; J Steven Leeder
Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(7):770-5.
1999: Susan M Abdel-Rahman; RR Gotschall; R E Kauffman; J Steven Leeder; Gregory L Kearns
Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Clinical pharmacology and therapeutics 1999;65(5):465-72.
1998: Andrea Gaedigk; R F Tyndale; M Jurima-Romet; E M Sellers; D M Grant; J Steven Leeder
NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Pharmacogenetics 1998;8(4):305-13.
1998: Dianne L Bradford; Andrea Gaedigk; J Steven Leeder
High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data.
Psychopharmacology bulletin 1998;34(4):797-804.
1997: A E Cribb; L R Pohl; SP Spielberg; J Steven Leeder
Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
The Journal of pharmacology and experimental therapeutics 1997;282(2):1064-71.
1997: J Steven Leeder; G L Kearns
Pharmacogenetics in pediatrics. Implications for practice.
Pediatric clinics of North America 1997;44(1):55-77.