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Jan Burger

Research Profile

Disorders

B-Cell Chronic Lymphocytic Leukemia

Chemicals & Drugs

Anatomy

Physiology

Procedures

Phenomena

Tumor Microenvironment

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Publications

TOP 3
Jan A Burger; Emili Montserrat
Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling.
Xavier C Badoux; Jan A Burger; Stefan Faderl; Michael J Keating; Susan M O'Brien; Rachel Sargent; Sijin Wen; William G Wierda; Alessandra Ferrajoli
Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia.
Jan A Burger
Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape.

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All Publications

2013: Jan A Burger; Emili Montserrat
Coming full circle: 70 years of chronic lymphocytic leukemia cell redistribution, from glucocorticoids to inhibitors of B-cell receptor signaling.
Blood 2013;121(9):1501-9.
2013: Xavier C Badoux; Jan A Burger; Stefan Faderl; Michael J Keating; Susan M O'Brien; Rachel Sargent; Sijin Wen; William G Wierda; Alessandra Ferrajoli
Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(5):584-91.
2012: Jan A Burger
Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape.
Current opinion in oncology 2012;24(6):643-9.
2012: M Sivina; E Vasyutina; William G Wierda; J M Boucas; A Breuer; E Hartmann; Marco Herling; Michael J Keating; A Rosenwald; Jan A Burger
Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia.
Leukemia 2012;26(8):1812-20.
2012: J Hoellenriegel; Michael J Keating; Susan O'Brien; A Pandey; Farhad Ravandi; U Sinha; M Sivina; William G Wierda; G P Coffey; Alessandra Ferrajoli; Jan A Burger
Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration.
Leukemia 2012;26(7):1576-83.
2012: Jan A Burger
BRAF mutation: supporting diversity in HCL.
Blood 2012;119(14):3193-4.
2012: Pierre Saintigny; Jan A Burger
Recent advances in non-small cell lung cancer biology and clinical management.
Discovery medicine 2012;13(71):287-97.
2012: Preetesh Jain; Mohammad Javdan; Jonathan E Kolitz; Kanti R Rai; Andreas Rosenwald; Filiz Sen; Cristina P Sison; Lynne V Abruzzo; Steven L Allen; Tawfiqul A Bhuiya; Jan A Burger; Nicholas Chiorazzi; Pui Yan Chiu; Rajendra N Damle; Franziska K Feger; Barbara Sherry
Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance.
Haematologica 2012;97(4):599-607.
2012: Wan Zhang; Jan A Burger; Gang Chen; Carlo M Croce; Celia Garcia-Prieto; Michael J Keating; Jinyun Liu; Weiqin Lu; Helene Pelicano; William Plunkett; Dunyaporn Trachootham; Peng Huang
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.
Nature cell biology 2012;14(3):276-86.
2012: Jan A Burger
Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia.
Current hematologic malignancy reports 2012;7(1):26-33.
2012: Sabine Ponader; William G Wierda; Kumudha Balakrishnan; Joseph J Buggy; shih-shih chen; Nicholas Chiorazzi; Varsha Gandhi; Michael J Keating; Susan O'Brien; Jan A Burger
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.
Blood 2012;119(5):1182-9.
2012: Jan A Burger
The times they are a-changin': prognostic markers in the new era of BCR-targeting therapies for CLL.
Expert opinion on medical diagnostics 2012;6(1):49-57.
2012: Jan A Burger
Disrupting the food chain in B cell lymphomas: co-operation between CXCR4 antagonists and antibodies.
Leukemia & lymphoma 2012;53(1):3-4.
2011: William G Wierda; Charles A Koller; Susan Lerner; Susan O'Brien; Ellen Schlette; Deborah Thomas; Xuemei Wang; Lynne Abruzzo; Jan A Burger; Jorge Cortes; Kim-Anh Do; Stefan Faderl; Alessandra Ferrajoli; Guillermo Garcia-Manero; Hagop M Kantarjian; Michael J Keating
Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(31):4088-95.
2011: Jan A Burger; Richard J Ford
The microenvironment in mantle cell lymphoma: cellular and molecular pathways and emerging targeted therapies.
Seminars in cancer biology 2011;21(5):308-12.
2011: Jan A Burger; Julia Hoellenriegel
Phosphoinositide 3'-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia..
Oncotarget 2011;2(10):737-8.
2011: Julia Hoellenriegel; Hagop Kantarjian; Michael J Keating; Brian J Lannutti; Sarah A Meadows; Langdon L Miller; Susan O'Brien; Mariela Sivina; William G Wierda; Albert Yu; Neill Giese; Jan A Burger
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.
Blood 2011;118(13):3603-12.
2011: Xavier C Badoux; Jan A Burger; Stefan Faderl; Michael J Keating; Steven M Kornblau; Bang-Ning Lee; Susan M O'Brien; James Reuben; Mariela Sivina; Sijin Wen; William G Wierda; Alessandra Ferrajoli
Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.
Blood 2011;118(13):3489-98.
2011: Jan A Burger; Mariela Sivina; Farhad Ravandi
The microenvironment in hairy cell leukemia: pathways and potential therapeutic targets.
Leukemia & lymphoma 2011;52 Suppl 2():94-8.
2011: Jan A Burger; David J Stewart; Ori Wald; Amnon Peled
Potential of CXCR4 antagonists for the treatment of metastatic lung cancer.
Expert review of anticancer therapy 2011;11(4):621-30.
2011: Mariela Sivina; Elena Hartmann; Thomas J Kipps; Laura Rassenti; Diana Krupnik; Susan Lerner; Ruth Lapushin; Lianchun Xiao; Xuelin Huang; Lillian Werner; Donna Neuberg; Hagop Kantarjian; Susan O'Brien; William G Wierda; Michael J Keating; Andreas Rosenwald; Jan A Burger
CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia.
Blood 2011;117(5):1662-9.
2011: Jan A Burger
Nurture versus nature: the microenvironment in chronic lymphocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2011;2011():96-103.
2010: Sameer A Parikh; Yogesh Bhusal; Stefan H Faderl; William G Wierda; Susan O'Brien; Hagop Kantarjian; Javier A Adachi; Jan A Burger
The great imitator: systemic nocardiosis mimicking Richter's transformation in relapsed chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(35):e732-4.
2010: Jan A Burger
Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): from understanding the basics towards therapeutic targeting.
Seminars in cancer biology 2010;20(6):424-30.
2010: Sabine Ponader; Jan A Burger
Modeling the marrow stem cell niche in vitro: is proximity the key to reproduction?
Haematologica 2010;95(9):e5.
2010: Kumudha Balakrishnan; Jan A Burger; Maite P Quiroga; Marina Henneberg; Mary L Ayres; William G Wierda; Varsha Gandhi
Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.
Blood 2010;116(7):1083-91.
2010: Jan A Burger
Angiopoietin-2 in CLL.
Blood 2010;116(4):508-9.
2010: Maite P Quiroga; Jan A Burger
BCR-mediated decrease of CXCR4 and CD62L in CLL.
Cancer research 2010;70(12):5194; author reply 5195.
2010: Jan A Burger; N S Velev; Elias Jabbour; William G Wierda; Farhad Ravandi; Jorge E Cortes; Andrew Lamb; Y L Nieto; Elizabeth J Shpall; Jeffrey L Jorgensen
Failure is not fatal: long-term remission in refractory acute myeloid leukemia (AML) after graft failure of cord blood stem cells.
Leukemia 2010;24(3):666-8.
2010: Gheath Alatrash; Maher Albitar; Susan O'Brien; Xuemei Wang; Taghi Manshouri; Stefan Faderl; Alessandra Ferrajoli; Jan Burger; Guillermo Garcia-Manero; Hagop M Kantarjian; Susan Lerner; Michael J Keating; Jan A Burger
Circulating CD52 and CD20 levels at end of treatment predict for progression and survival in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab (FCR).
British journal of haematology 2010;148(3):386-93.
2009: Antonina V Kurtova; Kumudha Balakrishnan; Rong Chen; Wei Ding; Susanne Schnabl; Maite P Quiroga; Mariela Sivina; William G Wierda; Zeev Estrov; Michael J Keating; Medhat Shehata; Ulrich Jäger; Varsha Gandhi; Neil E Kay; William Plunkett; Jan A Burger
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.
Blood 2009;114(20):4441-50.
2009: Jan A Burger; Paolo Ghia; Andreas Rosenwald; Federico Caligaris-Cappio
The microenvironment in mature B-cell malignancies: a target for new treatment strategies.
Blood 2009;114(16):3367-75.
2009: Jan A Burger; Varsha Gandhi
The lymphatic tissue microenvironments in chronic lymphocytic leukemia: in vitro models and the significance of CD40-CD154 interactions.
Blood 2009;114(12):2560-1; author reply 2561-2.
2009: Elias Jabbour; Daniel Jones; Hagop M Kantarjian; Susan O'Brien; Constantine Tam; Charles Koller; Jan A Burger; Gautam Borthakur; William G Wierda; Jorge Cortes
Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations.
Blood 2009;114(10):2037-43.
2009: Yesid Alvarado; Andrew Lamb; Susan O'Brien; Stefan Faderl; Gautam Borthakur; Jan Burger; Jan A Burger; Guillermo Garcia-Manero; Jianqin Shan; Jorge Cortes
Significance of suboptimal response to imatinib, as defined by the European LeukemiaNet, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase.
Cancer 2009;115(16):3709-18.
2009: Maite P Quiroga; Kumudha Balakrishnan; Antonina V Kurtova; Mariela Sivina; Michael J Keating; William G Wierda; Varsha Gandhi; Jan A Burger
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.
Blood 2009;114(5):1029-37.
2009: Jan A Burger
CXCR4 in acute myelogenous leukemia (AML): when too much attraction is bad for you.
Leukemia research 2009;33(6):747-8.
2009: Matthias Niedermeier; Bryan T. J. Hennessy; Zachary A Knight; Marina Henneberg; Jianhua Hu; Antonina V Kurtova; William G Wierda; Michael J Keating; Kevan M Shokat; Jan A Burger
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.
Blood 2009;113(22):5549-57.
2009: Antonina V Kurtova; Archito Tamayo; Richard J Ford; Jan A Burger
Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting.
Blood 2009;113(19):4604-13.
2009: Jan A Burger; David J Stewart
CXCR4 chemokine receptor antagonists: perspectives in SCLC.
Expert opinion on investigational drugs 2009;18(4):481-90.
2009: Jan A Burger; Susan O'Brien; Xuemei Wang; Stefan Faderl; Alessandra Ferrajoli; Kim-Anh Do; Guillermo Garcia-Manero; Jorge Cortes; Deborah Thomas; Charles Koller; Jan Burger; Susan Lerner; Andrew Lamb; Michael Keating
Characteristics associated with important clinical end points in patients with chronic lymphocytic leukemia at initial treatment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(10):1637-43.
2009: Jan A Burger; Maite P Quiroga; Elena Hartmann; Andrea Bürkle; William G Wierda; Michael J Keating; Andreas Rosenwald
High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation.
Blood 2009;113(13):3050-8.
2009: Jan A Burger; A Peled
CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers.
Leukemia 2009;23(1):43-52.
2009: Kumudha Balakrishnan; Jan A Burger; William G Wierda; Varsha Gandhi
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.
Blood 2009;113(1):149-53.
2008: Alessandra Ferrajoli; Jan A Burger; Ruth Lapushin; Susan M O'Brien; Stefan Faderl; Mary L Browning; Michael J Keating
Pilot experience with continuous infusion alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia.
European journal of haematology 2008;80(4):296-8.
2007: Andrea Bürkle; Matthias Niedermeier; Annette Schmitt-Gräff; William G Wierda; Michael J Keating; Jan A Burger
Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
Blood 2007;110(9):3316-25.
2007: Jan A Burger
No cell is an island unto itself: the stromal microenvironment in chronic lymphocytic leukemia.
Leukemia research 2007;31(7):887-8.
2007: Jan A Burger; Andrea Bürkle
The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target.
British journal of haematology 2007;137(4):288-96.
2007: Anke C Spoo; Michael Lübbert; William G Wierda; Jan A Burger
CXCR4 is a prognostic marker in acute myelogenous leukemia.
Blood 2007;109(2):786-91.
2006: Jan A Burger; Annette Schmitt-Gräff; Andrea Bürkle; Lysann Seiler; Jürgen Finke
Imatinib mesylate-induced long-term remission in extra-medullary T-cell lymphoid blastic phase of chronic myelogenous leukemia.
Leukemia & lymphoma 2006;47(11):2427-30.
2006: Jan A Burger; Thomas Kipps
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
Blood 2006;107(5):1761-7.
2005: Meike Burger; Tanja Hartmann; Myriam Krome; Justyna Rawluk; Hirokazu Tamamura; Nobutaka Fujii; Thomas Kipps; Jan A Burger
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.
Blood 2005;106(5):1824-30.
2005: Tanja Hartmann; Jan A Burger; Aleksandra Glodek; Nobutaka Fujii; Meike Burger
CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
Oncogene 2005;24(27):4462-71.
2005: Meike Burger; Tanja Hartmann; Jan A Burger; Ingrid Schraufstatter
KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway.
Oncogene 2005;24(12):2067-75.
2004: Robert Zeiser; Kristina Mikesch; Paul Fisch; Hans-Eckart Schaefer; Jan A Burger
Extramedullary plasmocytoma with local amyloidosis presenting as a lump on the lip.
British journal of haematology 2004;125(6):679.
2004: Tanja Hartmann; Meike Burger; Jan A Burger
The role of adhesion molecules and chemokine receptor CXCR4 (CD184) in small cell lung cancer.
Journal of biological regulators and homeostatic agents 2004;18(2):126-30.
2004: Robert Zeiser; Jan A Burger; Thorsten A Bley; Marissa Windfuhr-Blum; Jürgen Schulte-Mönting; Dirk Behringer
Clinical follow-up indicates differential accuracy of magnetic resonance imaging and immunocytology of the cerebral spinal fluid for the diagnosis of neoplastic meningitis - a single centre experience.
British journal of haematology 2004;124(6):762-8.
2003: Meike Burger; Aleksandra Glodek; Tanja Hartmann; Annette Schmitt-Gräff; Leslie E Silberstein; Nobutaka Fujii; Thomas Kipps; Jan A Burger
Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.
Oncogene 2003;22(50):8093-101.
2003: Jan A Burger; Anke Spoo; Anne Dwenger; Meike Burger; Dirk Behringer
CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis).
British journal of haematology 2003;122(4):579-89.
2002: Tobias B Huber; Hans Christian Reinhardt; Markus Exner; Jan A Burger; Dontscho Kerjaschki; Moin A Saleem; Hermann Pavenstädt
Expression of functional CCR and CXCR chemokine receptors in podocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6244-52.
2002: Jan A Burger; Thomas Kipps
Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells.
Leukemia & lymphoma 2002;43(3):461-6.
2002: Nobuhiro Tsukada; Jan A Burger; Nathan J Zvaifler; Thomas Kipps
Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia.
Blood 2002;99(3):1030-7.
2001: Anthony A Horner; George F Widhopf; Jan A Burger; Kenji Takabayashi; N Cinman; Arash Ronaghy; Hans L Spiegelberg; Eyal Raz
Immunostimulatory DNA inhibits IL-4-dependent IgE synthesis by human B cells.
The Journal of allergy and clinical immunology 2001;108(3):417-23.
2001: Jan A Burger; R B Mendoza; Thomas Kipps
Plasmids encoding granulocyte-macrophage colony-stimulating factor and CD154 enhance the immune response to genetic vaccines.
Vaccine 2001;19(15-16):2181-9.
2001: Jan A Burger; Nathan J Zvaifler; Nobuhiro Tsukada; Gary S Firestein; Thomas Kipps
Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism.
The Journal of clinical investigation 2001;107(3):305-15.
2000: Jan A Burger; Nobuhiro Tsukada; Meike Burger; Nathan J Zvaifler; M Dell'Aquila; Thomas Kipps
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.
Blood 2000;96(8):2655-63.
2000: Jan A Burger; S M Baird; H C Powell; S Sharma; David J Eling; Thomas Kipps
Local and systemic effects after adenoviral transfer of the murine granulocyte-macrophage colony-stimulating factor gene into mice.
British journal of haematology 2000;108(3):641-52.
2000: Nathan J Zvaifler; L Marinova-Mutafchieva; G Adams; C J Edwards; J Moss; Jan A Burger; Ravinder N Maini
Mesenchymal precursor cells in the blood of normal individuals.
Arthritis research 2000;2(6):477-88.
1999: Jan A Burger; M Burger; Thomas Kipps
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.
Blood 1999;94(11):3658-67.
1999: Meike Burger; Jan A Burger; RC Hoch; ZG Oades; Hiroshi Takamori; Ingrid Schraufstatter
Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptor.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2017-22.
1997: M Sach; Jan A Burger; A Engelhardt; U P Ketelsen; Peter Schollmeyer
[Temporary hemiparesis and Raynaud symptoms in eosinophilic fasciitis].
Der Internist 1997;38(7):688-91.
1997: M Sach; K Bauermeister; Jan A Burger; P Loetscher; J Elsner; Peter Schollmeyer; GJ Dobos
Inverse MCP-1/IL-8 ratio in effluents of CAPD patients with peritonitis and in isolated cultured human peritoneal macrophages.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1997;12(2):315-20.
1997: Jan A Burger; Andreas Ochs; K Wirth; Dietmar P Berger; Roland Mertelsmann; R Engelhardt; M Roessle; Klaus Haag
The transjugular stent implantation for the treatment of malignant portal and hepatic vein obstruction in cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(2):200-2.
1997: Hartmut Bertz; Jan A Burger; Regina Kunzmann; Roland Mertelsmann; Jürgen Finke
Adoptive immunotherapy for relapsed multiple myeloma after allogeneic bone marrow transplantation (BMT): evidence for a graft-versus-myeloma effect.
Leukemia 1997;11(2):281-3.
1995: Jan A Burger; Ulrich Schöffel; M Sach; E Jacobs; E Kownatzki; Bernd Ulrich von Specht; Eduard H Farthmann
Effects of peritonitis exudates on chemotaxis and phagocytosis of human neutrophils.
The European journal of surgery = Acta chirurgica 1995;161(9):647-53.
1995: M Sach; P Loetscher; Jan A Burger; H P Knopf; Peter Schollmeyer; GJ Dobos
MCP-1 levels are elevated in peritonitis fluid from CAPD patients due to secretion by peritoneal macrophages.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 1995;11():19-23.