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Peter Daniel

Research Profile

Chemicals & Drugs

Anatomy

Physiology

Living Beings

Mouse

Genes & Molecular Sequences

Genes, p53

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Publications

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M Plötz; Peter Daniel; Bernhard Gillissen; Amir M Hossini; Jürgen Eberle
Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.
Annika Müer; Tim Overkamp; Thomas Pretzsch; Antje Richter; Peter Daniel; Bernd Dörken; Bernhard Gillissen; Ana Milojkovic; Philipp G Hemmati
p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.
Michael Plötz; Eggert Stockfleth; Peter Daniel; Bernhard Gillissen; Amir M Hossini; Jürgen Eberle
Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK).

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All Publications

2012: M Plötz; Peter Daniel; Bernhard Gillissen; Amir M Hossini; Jürgen Eberle
Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells.
Cell death and differentiation 2012;19(12):1928-38.
2012: Annika Müer; Tim Overkamp; Thomas Pretzsch; Antje Richter; Peter Daniel; Bernd Dörken; Bernhard Gillissen; Ana Milojkovic; Philipp G Hemmati
p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.
The Journal of biological chemistry 2012;287(21):17343-52.
2012: Michael Plötz; Eggert Stockfleth; Peter Daniel; Bernhard Gillissen; Amir M Hossini; Jürgen Eberle
Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK).
PloS one 2012;7(4):e34549.
2011: V Graupner; T Overkamp; O Rothfuss; Klaus Schulze-Osthoff; E Alexander; Peter Daniel; V De Laurenzi; Bernhard Gillissen; Frank Essmann
Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level.
Cell death and differentiation 2011;18(7):1130-9.
2011: Clarissa von Haefen; Jana Wendt; Geo Semini; Marco Sifringer; Claus Belka; Silke Radetzki; Werner Reutter; Peter Daniel; Kerstin Danker
Synthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway.
Apoptosis : an international journal on programmed cell death 2011;16(6):636-51.
2010: Philipp G Hemmati; Annika Müer; Bernhard Gillissen; Tim Overkamp; Ana Milojkovic; Jana Wendt; Bernd Dörken; Peter Daniel
Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3.
Journal of molecular medicine (Berlin, Germany) 2010;88(6):609-22.
2010: Bernhard Gillissen; Jana Wendt; Antje Richter; Anja Richter; Annika Müer; Tim Overkamp; Nina Gebhardt; Robert Preissner; Claus Belka; Bernd Dörken; Peter Daniel
Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.
The Journal of cell biology 2010;188(6):851-62.
2008: D Neise; V Graupner; Bernhard Gillissen; Peter Daniel; Klaus Schulze-Osthoff; Reiner U Jänicke; Frank Essmann
Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak.
Oncogene 2008;27(10):1387-96.
2007: Bernhard Gillissen; Frank Essmann; Philipp G Hemmati; Antje Richter; Anja Richter; Ilker Oztop; Govindaswamy Chinnadurai; Bernd Dörken; Peter Daniel
Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis.
The Journal of cell biology 2007;179(4):701-15.
2007: Niko Zantl; Gregor Weirich; H Zall; Barbara M Seiffert; Silke F Fischer; Susanne Kirschnek; C Hartmann; R M Fritsch; Bernhard Gillissen; Peter Daniel; G Häcker
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance.
Oncogene 2007;26(49):7038-48.
2006: Philipp G Hemmati; Dilek Güner; Bernhard Gillissen; Jana Wendt; Clarissa von Haefen; Govindaswamy Chinnadurai; Bernd Dörken; Peter Daniel
Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells.
Oncogene 2006;25(50):6582-94.
2006: Patrizia Marini; S Denzinger; D Schiller; S Kauder; Stefan Welz; Robin Humphreys; Peter Daniel; Verena Jendrossek; Wilfried Budach; Claus Belka
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo.
Oncogene 2006;25(37):5145-54.
2006: Hongbo Hu; Cheng Jiang; Todd Schuster; Guang-Xun Li; Peter Daniel; Junxuan Lü
Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.
Molecular cancer therapeutics 2006;5(7):1873-82.
2006: Lothar F Fecker; Christoph C Geilen; Georgi Tchernev; Uwe Trefzer; Chalid Assaf; Bahtier M Kurbanov; Constanze Schwarz; Peter Daniel; Jürgen Eberle
Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis.
The Journal of investigative dermatology 2006;126(6):1366-71.
2006: Isrid Sturm; Andrew G Bosanquet; Silke Radetzki; Michael Hummel; Bernd Dörken; Peter Daniel
Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation.
International journal of cancer. Journal international du cancer 2006;118(9):2329-36.
2006: Amir M Hossini; Christoph C Geilen; Lothar F Fecker; Peter Daniel; Jürgen Eberle
A novel Bcl-x splice product, Bcl-xAK, triggers apoptosis in human melanoma cells without BH3 domain.
Oncogene 2006;25(15):2160-9.
2006: M Burek; Subbareddy Maddika; Christof J Burek; Peter Daniel; Klaus Schulze-Osthoff; Marek Los
Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.
Oncogene 2006;25(15):2213-22.
2006: Patricia Grabowski; Isrid Sturm; Katharina Schelwies; Kerstin Maaser; Heinz J Buhr; Bernd Dörken; Martin Zeitz; Peter Daniel; Hans Scherübl
Analysis of neuroendocrine differentiation and the p53/BAX pathway in UICC stage III colorectal carcinoma identifies patients with good prognosis.
International journal of colorectal disease 2006;21(3):221-30.
2006: Isrid Sturm; C Stephan; Bernhard Gillissen; R Siebert; M Janz; Silke Radetzki; Klaus Jung; S Loening; Bernd Dörken; Peter Daniel
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
Cell death and differentiation 2006;13(4):619-27.
2006: Mandar R Bhonde; Marie-Luise Hanski; Jan Budczies; Minh Cao; Bernhard Gillissen; Dhatchana Moorthy; Federico Simonetta; Hans Scherübl; Matthias Truss; Christian Hagemeier; Hans-Werner Mewes; Peter Daniel; Martin Zeitz; Christoph Hanski
DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis.
The Journal of biological chemistry 2006;281(13):8675-85.
2006: Jana Wendt; Silke Radetzki; Clarissa von Haefen; Philipp G Hemmati; Dilek Güner; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells.
Oncogene 2006;25(7):972-80.
2006: Peter Daniel; Ulrich Koert; Julia Schuppan
Apoptolidin: induction of apoptosis by a natural product.
Angewandte Chemie (International ed. in English) 2006;45(6):872-93.
2006: Mandar R Bhonde; Marie-Luise Hanski; Michael Notter; Bernhard Gillissen; Peter Daniel; Martin Zeitz; Christoph Hanski
Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth.
Oncogene 2006;25(2):165-75.
2006: Isrid Sturm; Beate Rau; Peter M Schlag; Peter Wust; Bert Hildebrandt; Hanno Riess; Steffen Hauptmann; Bernd Dörken; Peter Daniel
Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy.
BMC cancer 2006;6():124.
2006: Daniel Habermehl; Bernd Kammerer; René Handrick; Therese Eldh; Charlotte Gruber; Nils Cordes; Peter Daniel; Ludwig Plasswilm; D D; Claus Belka; Verena Jendrossek
Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.
BMC cancer 2006;6():14.
2005: Thorsten Stühmer; Manik Chatterjee; Martin Hildebrandt; Pia Herrmann; Hella Gollasch; Christian Gerecke; Sebastian Theurich; Luisa Cigliano; Rudolf A Manz; Peter Daniel; Kurt Bommert; Lyubomir T Vassilev; Ralf C Bargou
Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma.
Blood 2005;106(10):3609-17.
2005: Malte Oppermann; Christoph C Geilen; Lothar F Fecker; Bernhard Gillissen; Peter Daniel; Jürgen Eberle
Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik.
Oncogene 2005;24(49):7369-80.
2005: Frank Essmann; Stephan Pohlmann; Bernhard Gillissen; Peter Daniel; Klaus Schulze-Osthoff; Reiner U Jänicke
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis.
The Journal of biological chemistry 2005;280(44):37169-77.
2005: Christian Scholz; Antje Richter; Mario Lehmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway.
Oncogene 2005;24(47):7031-42.
2005: Lilian Stärck; Christian Scholz; Thomas Blankenstein; Bernd Dörken; Peter Daniel
Necrotic death but not irradiation abolishes costimulation of T-cell effector functions and survival by CD80-expressing tumor cells.
International journal of cancer. Journal international du cancer 2005;116(1):78-86.
2005: Peter Daniel; B Dörken
[Basics of molecular diagnostics and therapy of malignant tumors].
Der Internist 2005;46(8):835-6, 838-42, 844-6.
2005: Jana Wendt; Clarissa von Haefen; Philipp G Hemmati; Claus Belka; Bernd Dörken; Peter Daniel
TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway.
Oncogene 2005;24(25):4052-64.
2005: Philipp G Hemmati; Guillaume Normand; Berlinda Verdoodt; Clarissa von Haefen; Anne Hasenjäger; Dilek Güner; Jana Wendt; Bernd Dörken; Peter Daniel
Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells.
Oncogene 2005;24(25):4114-28.
2005: Dhyan Chandra; Grace Choy; Peter Daniel; Ding "Dean" G. Tang
Bax-dependent regulation of Bak by voltage-dependent anion channel 2.
The Journal of biological chemistry 2005;280(19):19051-61.
2005: Lilian Stärck; Christian Scholz; Bernd Dörken; Peter Daniel
Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP(short) via phosphatidylinositol 3-kinase and AKT/protein kinase B.
European journal of immunology 2005;35(4):1257-66.
2005: Christian Scholz; Thomas Wieder; Lilian Stärck; Frank Essmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway.
Oncogene 2005;24(11):1904-13.
2005: Guillaume Normand; Philipp G Hemmati; Berlinda Verdoodt; Clarissa von Haefen; Jana Wendt; Dilek Güner; Evelyne May; Bernd Dörken; Peter Daniel
p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.
The Journal of biological chemistry 2005;280(8):7118-30.
2005: Patrizia Marini; Angelika Schmid; Verena Jendrossek; Heidrun Faltin; Peter Daniel; Wilfried Budach; Claus Belka
Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis.
BMC cancer 2005;5():5.
2005: Justine Rudner; Verena Jendrossek; Kirsten Lauber; Peter Daniel; Sebastian Wesselborg; Claus Belka
Type I and type II reactions in TRAIL-induced apoptosis -- results from dose-response studies.
Oncogene 2005;24(1):130-40.
2005: Mandar R Bhonde; Marie-Luise Hanski; Roberta Magrini; Dhatchana Moorthy; Antje Müller; Edward A Sausville; Kimitoshi Kohno; Peter Wiegand; Peter Daniel; Martin Zeitz; Christoph Hanski
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
Oncogene 2005;24(1):148-56.
2005: Isrid Sturm; Andrew G Bosanquet; Michael Hummel; Bernd Dörken; Peter Daniel
In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.
BMC cancer 2005;5():105.
2004: Antje Klöpfer; Anne Hasenjäger; Claus Belka; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway.
Oncogene 2004;23(58):9408-18.
2004: Clarissa von Haefen; Bernhard Gillissen; Philipp G Hemmati; Jana Wendt; Dilek Güner; Alicja Mrozek; Claus Belka; Bernd Dörken; Peter Daniel
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway.
Oncogene 2004;23(50):8320-32.
2004: Karin Schmelz; Thomas Wieder; Ingo Tamm; Antje Müller; Frank Essmann; Christoph C Geilen; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB.
Oncogene 2004;23(40):6743-59.
2004: Anne Hasenjäger; Bernhard Gillissen; Antje Müller; Guillaume Normand; Philipp G Hemmati; Martin Schuler; Bernd Dörken; Peter Daniel
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.
Oncogene 2004;23(26):4523-35.
2003: Jürgen Eberle; Lothar F Fecker; Amir M Hossini; Thomas Wieder; Peter Daniel; Constantin E Orfanos; Christoph C Geilen
CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants.
Oncogene 2003;22(57):9131-41.
2003: Aram Prokop; Wolfgang Wrasidlo; Holger Lode; Ralf Herold; Florian Lang; Günter Henze; Bernd Dörken; Thomas Wieder; Peter Daniel
Induction of apoptosis by enediyne antibiotic calicheamicin thetaII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner.
Oncogene 2003;22(57):9107-20.
2003: Carsten Denkert; Antje Fürstenberg; Peter Daniel; Ines Koch; Martin Köbel; Wilko Weichert; Antje Siegert; Steffen Hauptmann
Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference.
Oncogene 2003;22(54):8653-61.
2003: Beate Rau; Isrid Sturm; Hermann Lage; Stefan Berger; Ulrike Schneider; Steffen Hauptmann; Peter Wust; Hanno Riess; Peter M Schlag; Bernd Dörken; Peter Daniel
Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(18):3391-401.
2003: Dilek Güner; Claus Belka; Peter Daniel
Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy.
Current medicinal chemistry. Anti-cancer agents 2003;3(5):319-26.
2003: Bernhard Gillissen; Frank Essmann; Vilma Graupner; Lilian Stärck; Silke Radetzki; Bernd Dörken; Klaus Schulze-Osthoff; Peter Daniel
Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway.
The EMBO journal 2003;22(14):3580-90.
2003: Clarissa von Haefen; Thomas Wieder; Frank Essmann; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop.
Oncogene 2003;22(15):2236-47.
2003: Isrid Sturm; Andrew G Bosanquet; Sandra Hermann; Dilek Güner; Bernd Dörken; Peter Daniel
Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy.
Cell death and differentiation 2003;10(4):477-84.
2003: A Mrózek; Henrik Petrowsky; Isrid Sturm; J Kraus; Sandra Hermann; S Hauptmann; M Lorenz; Bernd Dörken; Peter Daniel
Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability.
Cell death and differentiation 2003;10(4):461-7.
2003: Dilek Güner; Isrid Sturm; Philipp G Hemmati; Sandra Hermann; Steffen Hauptmann; Reinhard Wurm; Volker Budach; Bernd Dörken; Matthias Lorenz; Peter Daniel
Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis.
International journal of cancer. Journal international du cancer 2003;103(4):445-54.
2003: Peter Daniel; Klaus Schulze-Osthoff; Claus Belka; Dilek Güner
Guardians of cell death: the Bcl-2 family proteins.
Essays in biochemistry 2003;39():73-88.
2002: Christian Scholz; Lilian Stärck; Gerald Willimsky; Thomas Blankenstein; Bernd Dörken; Peter Daniel
Adenoviral transduction of tumor cells induces apoptosis in co-cultured T lymphocytes.
Gene therapy 2002;9(21):1438-46.
2002: Clarissa von Haefen; Thomas Wieder; Bernhard Gillissen; Lilian Stärck; Vilma Graupner; Bernd Dörken; Peter Daniel
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells.
Oncogene 2002;21(25):4009-19.
2002: Andrew G Bosanquet; Isrid Sturm; Thomas Wieder; Frank Essmann; M I Bosanquet; D J Head; Bernd Dörken; Peter Daniel
Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia.
Leukemia 2002;16(6):1035-44.
2002: Katharina Schelwies; Isrid Sturm; Patricia Grabowski; Hans Scherübl; Isabell Schindler; Sandra Hermann; Harald Stein; Heinz J Buhr; Ernst O Riecken; Martin Zeitz; Bernd Dörken; Peter Daniel
Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors.
International journal of cancer. Journal international du cancer 2002;99(4):589-96.
2002: Philipp G Hemmati; Bernhard Gillissen; Clarissa von Haefen; Jana Wendt; Lilian Stärck; Dilek Güner; Bernd Dörken; Peter Daniel
Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis.
Oncogene 2002;21(20):3149-61.
2002: Silke Radetzki; Claus-Henning Köhne; Clarissa von Haefen; Bernhard Gillissen; Isrid Sturm; Bernd Dörken; Peter Daniel
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines.
Oncogene 2002;21(2):227-38.
2001: Thomas Wieder; A Prokop; B Bagci; Frank Essmann; D Bernicke; Klaus Schulze-Osthoff; Bernd Dörken; Hans-Günther Schmalz; Peter Daniel; Günter Henze
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts.
Leukemia 2001;15(11):1735-42.
2001: Monika Raisova; Amir M Hossini; Jürgen Eberle; Christian Riebeling; Thomas Wieder; Isrid Sturm; Peter Daniel; Constantin E Orfanos; Christoph C Geilen
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.
The Journal of investigative dermatology 2001;117(2):333-40.
2001: Peter Daniel; Thomas Wieder; Isrid Sturm; Klaus Schulze-Osthoff
The kiss of death: promises and failures of death receptors and ligands in cancer therapy.
Leukemia 2001;15(7):1022-32.
2001: Sandra Hermann; Isrid Sturm; A Mrozek; B Klosterhalfen; Steffen Hauptmann; Bernd Dörken; Peter Daniel
Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma.
International journal of cancer. Journal international du cancer 2001;92(6):805-11.
2001: K Friedrich; Thomas Wieder; Clarissa von Haefen; Silke Radetzki; Reiner U Jänicke; Klaus Schulze-Osthoff; Bernd Dörken; Peter Daniel
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance.
Oncogene 2001;20(22):2749-60.
2001: Isrid Sturm; Henrik Petrowsky; R Volz; Matthias Lorenz; Silke Radetzki; Timo Hillebrand; Gerhard Wolff; Steffen Hauptmann; Bernd Dörken; Peter Daniel
Analysis of p53/BAX/p16(ink4a/CDKN2) in esophageal squamous cell carcinoma: high BAX and p16(ink4a/CDKN2) identifies patients with good prognosis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(8):2272-81.
2001: Thomas Wieder; Frank Essmann; A Prokop; Karin Schmelz; Klaus Schulze-Osthoff; Rudi Beyaert; Bernd Dörken; Peter Daniel
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.
Blood 2001;97(5):1378-87.
2001: Henrik Petrowsky; Isrid Sturm; O Graubitz; David A Kooby; Elsbeth Staib-Sebler; Christiane Gog; Claus-Henning Köhne; Timo Hillebrand; Peter Daniel; Yuman Fong; Matthias Lorenz
Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2001;27(1):80-7.
2000: Peter Daniel
Dissecting the pathways to death.
Leukemia 2000;14(12):2035-44.
2000: A Prokop; Thomas Wieder; Isrid Sturm; Frank Essmann; K Seeger; C Wuchter; W D Ludwig; Günter Henze; B Dörken; Peter Daniel
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo.
Leukemia 2000;14(9):1606-13.
2000: Isrid Sturm; Sarantos Papadopoulos; Timo Hillebrand; Thomas Benter; H J Lück; Gerhard Wolff; Bernd Dörken; Peter Daniel
Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene.
International journal of cancer. Journal international du cancer 2000;87(4):517-21.
2000: A Löffler; Peter Kufer; Ralf Lutterbüse; F Zettl; Peter Daniel; J M Schwenkenbecher; Gert Riethmüller; Bernd Dörken; Ralf C Bargou
A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes.
Blood 2000;95(6):2098-103.
2000: Frank Essmann; Thomas Wieder; A Otto; E C Müller; Bernd Dörken; Peter Daniel
GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis.
The Biochemical journal 2000;346 Pt 3():777-83.
1999: Peter Daniel; Christian Scholz; Frank Essmann; J Westermann; Antonio Pezzutto; Bernd Dörken
CD95/Fas-triggered apoptosis of activated T lymphocytes is prevented by dendritic cells through a CD58-dependent mechanism.
Experimental hematology 1999;27(9):1402-8.
1999: Peter Daniel; K T Pun; S Ritschel; Isrid Sturm; J Holler; B Dörken; R Brown
Expression of the death gene Bik/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice.
Blood 1999;94(3):1100-7.
1999: Isrid Sturm; Claus-Henning Köhne; Gerhard Wolff; Henrik Petrowsky; Timo Hillebrand; Steffen Hauptmann; Matthias Lorenz; Bernd Dörken; Peter Daniel
Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(5):1364-74.
1999: Peter Daniel; Isrid Sturm; S Ritschel; K Friedrich; Bernd Dörken; Peter Bendzko; Timo Hillebrand
Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers.
Analytical biochemistry 1999;266(1):110-5.
1998: Peter Daniel; A Kroidl; J Kopp; Isrid Sturm; G Moldenhauer; Bernd Dörken; Antonio Pezzutto
Immunotherapy of B-cell lymphoma with CD3x19 bispecific antibodies: costimulation via CD28 prevents "veto" apoptosis of antibody-targeted cytotoxic T cells.
Blood 1998;92(12):4750-7.
1998: Claus-Henning Köhne; Peter C Thuss-Patience; M Friedrich; Peter Daniel; Albrecht Kretzschmar; Thomas Benter; B Bauer; R Dietz; B Dörken
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity.
British journal of cancer 1998;77(6):973-7.
1998: Peter Daniel; A Kroidl; S Cayeux; C Scholz; Isrid Sturm; Thomas Blankenstein; Antonio Pezzutto; Bernd Dörken
Retroviral B7.1 gene transfer in cancer cells protects cytotoxic T cells from deletion by "veto" apoptosis.
Advances in experimental medicine and biology 1998;451():265-76.
1998: Peter Daniel; C Scholz; J Westermann; Bernd Dörken; Antonio Pezzutto
Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals.
Advances in experimental medicine and biology 1998;451():173-7.
1997: Peter Daniel; A Kroidl; S Cayeux; Ralf C Bargou; Thomas Blankenstein; Bernd Dörken
Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3808-15.
1997: Peter Daniel; U Oettinger; Markus Y Mapara; Kurt Bommert; Ralf C Bargou; Bernd Dörken
Activation and activation-induced death of human tonsillar B cells and Burkitt lymphoma cells: lack of CD95 (Fas/APO-1) ligand expression and function.
European journal of immunology 1997;27(4):1029-34.
1997: Claus-Henning Köhne; Peter Daniel; Bernd Dörken
The value of weekly high dose infusional 5-fluorouracil in the treatment of advanced colorectal cancer.
Tumori 1997;83(1 Suppl):S56-60.
1996: C Wagener; Ralf C Bargou; Peter Daniel; Kurt Bommert; Markus Y Mapara; hans-dieter royer; Bernd Dörken
Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis.
International journal of cancer. Journal international du cancer 1996;67(1):138-41.
1996: Ralf C Bargou; C Wagener; Kurt Bommert; Markus Y Mapara; Peter Daniel; W Arnold; M Dietel; H Guski; A Feller; hans-dieter royer; Bernd Dörken
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.
The Journal of clinical investigation 1996;97(11):2651-9.
1996: Ralf C Bargou; C Wagener; Kurt Bommert; W Arnold; Peter Daniel; Markus Y Mapara; E Grinstein; hans-dieter royer; Bernd Dörken
Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice.
The Journal of experimental medicine 1996;183(3):1205-13.
1995: Markus Y Mapara; Pamela Weinmann; Kurt Bommert; Peter Daniel; Ralf C Bargou; Bernd Dörken
Involvement of NAK-1, the human nur77 homologue, in surface IgM-mediated apoptosis in Burkitt lymphoma cell line BL41.
European journal of immunology 1995;25(9):2506-10.
1995: C Lagresle; Chantal Bella; Peter Daniel; P H Krammer; Thierry Defrance
Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5746-56.
1995: Ralf C Bargou; Peter Daniel; Markus Y Mapara; Kurt Bommert; C Wagener; B Kallinich; hans-dieter royer; Bernd Dörken
Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis.
International journal of cancer. Journal international du cancer 1995;60(6):854-9.
1995: L Blase; Peter Daniel; K Koretz; Reinhard Schwartz-Albiez; Peter Möller
The capacity of human malignant B-lymphocytes to disseminate in SCID mice is correlated with functional expression of the fibronectin receptor alpha 5 beta 1 (CD49e/CD29).
International journal of cancer. Journal international du cancer 1995;60(6):860-6.
1995: Ralf C Bargou; Kurt Bommert; Pamela Weinmann; Peter Daniel; C Wagener; Markus Y Mapara; Bernd Dörken
Induction of Bax-alpha precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosis.
European journal of immunology 1995;25(3):770-5.
1995: Katerina Chlichlia; Gerhard Moldenhauer; Peter Daniel; M Busslinger; L Gazzolo; Volker Schirrmacher; Khashayarsha Khazaie
Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis.
Oncogene 1995;10(2):269-77.
1994: Peter H Krammer; J Dhein; Henning Walczak; I Behrmann; SM Mariani; B Matiba; M Fath; Peter Daniel; E Knipping; M O Westendorp
The role of APO-1-mediated apoptosis in the immune system.
Immunological reviews 1994;142():175-91.
1994: K M Lücking-Famira; Peter Daniel; Peter Möller; Peter H Krammer; Klaus-Michael Debatin
APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.
Leukemia 1994;8(11):1825-33.
1994: L R Coney; Peter Daniel; D Sanborn; J Dhein; Klaus-Michael Debatin; Peter H Krammer; V R Zurawski
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.
International journal of cancer. Journal international du cancer 1994;58(4):562-7.
1994: J Dhein; I Behrmann; Peter Daniel; Klaus-Michael Debatin; C Klas; Peter Möller; A Oehm; B C Trauth; Henning Walczak; Peter H Krammer
APO-I-mediated apoptosis in normal and malignant lymphocytes.
Biochemical Society transactions 1994;22(3):598-600.
1994: Peter Daniel; Peter H Krammer
Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5624-32.
1993: Ralf C Bargou; Markus Y Mapara; C Zugck; Peter Daniel; M Pawlita; H Döhner; Bernd Dörken
Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.
The Journal of experimental medicine 1993;177(5):1257-68.
1992: J Dhein; Peter Daniel; B C Trauth; A Oehm; Peter Möller; Peter H Krammer
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3166-73.
1989: Peter Daniel; J Holzschuh; Peter A Berg
Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).
Thorax 1989;44(4):307-9.
1989: Peter Daniel; J Holzschuh; Christa E Müller; H J Roth; Peter A Berg
Inhibition of phytohemagglutinine-induced T lymphocyte proliferation by 6-(octadecyldithio)purine, a novel liposomal prodrug of 6-mercaptopurine.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():179-82.
1988: Peter A Berg; J Holzschuh; Peter Daniel; E W Becker; A Jedrychowski
[Cefotaxime-induced allergic agranulocytosis in an acute attack of serologically atypical primary biliary cirrhosis].
Deutsche medizinische Wochenschrift (1946) 1988;113(38):1478-81.
1988: Peter A Berg; Peter Daniel
Effects of flavonoid compounds on the immune response.
Progress in clinical and biological research 1988;280():157-71.
1988: Peter Daniel; J Holzschuh; G J Diao; Peter A Berg
Interference of the flavonoid compound cianidanol with macrophage function and lymphocyte activating mechanisms.
Progress in clinical and biological research 1988;280():205-9.
1988: Peter Daniel; J Holzschuh; Peter A Berg
The pathogenesis of cianidanol-induced fever.
European journal of clinical pharmacology 1988;34(3):241-7.
1987: Peter A Berg; Peter Daniel; J Holzschuh; Norbert Brattig
[Drug hypersensitivity. Diagnosis and immunopathogenesis].
Deutsche medizinische Wochenschrift (1946) 1987;113(2):65-73.
1987: Peter A Berg; Peter Daniel
Co-trimoxazole-induced hepatic injury--an analysis of cases with hypersensitivity-like reactions.
Infection 1987;15 Suppl 5():S259-64.
1986: J G Saal; Peter Daniel; P A Berg
Indoprofen-induced aplastic anemia in active connective tissue disease detected by drug-specific lymphocyte transformation.
Klinische Wochenschrift 1986;64(10):481-5.
1986: Peter Daniel; F Falcioni; Jörg Berg, EurClinChem; P A Berg
Influence of cianidanol on specific and non-specific immune mechanisms.
Methods and findings in experimental and clinical pharmacology 1986;8(3):139-45.
1985: J G Saal; Peter Daniel; P A Berg; H D Waller
Indoprofen-induced aplastic anaemia in systemic lupus, diagnosed by lymphocyte transformation tests.
Lancet 1985;1(8443):1450-1.