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José Salas

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TOP 3
Cristina Gómez; Carmen Méndez; Carlos Olano; José A Salas
Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.
Cristina Gómez; Dina H Horna; Carmen Méndez; Carlos Olano; José A Salas
Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.
Javier González-Sabín; Vicente Gotor; Carmen Méndez; Nuria Menéndez; Luz Elena Núñez; José A Salas; Alfredo F Braña; Francisco Morís
Lipase-catalyzed preparation of chromomycin A₃ analogues and biological evaluation for anticancer activity.

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All Publications

2012: Cristina Gómez; Carmen Méndez; Carlos Olano; José A Salas
Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.
Microbiology (Reading, England) 2012;158(Pt 10):2504-14.
2012: Cristina Gómez; Dina H Horna; Carmen Méndez; Carlos Olano; José A Salas
Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.
Microbial biotechnology 2012;5(5):663-7.
2012: Javier González-Sabín; Vicente Gotor; Carmen Méndez; Nuria Menéndez; Luz Elena Núñez; José A Salas; Alfredo F Braña; Francisco Morís
Lipase-catalyzed preparation of chromomycin A₃ analogues and biological evaluation for anticancer activity.
Bioorganic & medicinal chemistry letters 2012;22(13):4310-3.
2012: Cristina Gómez; Carmen Méndez; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; Alfredo F Braña; RJ Carbajo; José A Salas
Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.
The Journal of antibiotics 2012;65(7):341-8.
2012: Luz E Núñez; Stephen E Nybo; María Pérez; Jürgen Rohr; José A Salas; Khaled A Shaaban; Alfredo F Braña; Javier González-Sabín; Min He; Nuria Menéndez; Francisco Morís; Carmen Méndez
A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.
Journal of medicinal chemistry 2012;55(12):5813-25.
2012: Ignacio Garcia; Javier González-Sabin; Carmen Méndez; Francisco Moris; Jürgen Rohr; Alfredo F Braña; Natalia M Vior; José A Salas
Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring.
Chemistry & biology 2012;19(3):399-413.
2012: S Eric Nybo; Madan Kumar Kharel; Carmen Méndez; José A Salas; Khaled A Shabaan; Happy Sutardjo; Jürgen Rohr
Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT.
Bioorganic & medicinal chemistry letters 2012;22(6):2247-50.
2011: Cristina Gómez; Dina H Horna; Carmen Méndez; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; Alfredo F Braña; RJ Carbajo; José A Salas
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.
Journal of bacteriology 2011;193(16):4214-23.
2011: Dina H Horna; Cristina Gómez; Carlos Olano; Martina Palomino-Schätzlein; Antonio Pineda-Lucena; RJ Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.
Journal of bacteriology 2011;193(10):2647-51.
2011: Miriam Rodríguez; Luz Elena Núñez; Alfredo F Braña; Carmen Méndez; José A Salas; Gloria Blanco
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
Antimicrobial agents and chemotherapy 2011;55(4):1638-49.
2011: Beatriz García; Javier González-Sabín; Nuria Menéndez; Alfredo F Braña; Luz Elena Núñez; Francisco Morís; José A Salas; Carmen Méndez
The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.
Microbial biotechnology 2011;4(2):226-38.
2011: Carlos Olano; Carmen Méndez; José A Salas
Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.
Microbial biotechnology 2011;4(2):144-64.
2011: Micah D Shepherd; Tao Liu; Carmen Méndez; José A Salas; Jürgen Rohr
Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.
Applied and environmental microbiology 2011;77(2):435-41.
2010: Leonard Kaysser; Emmanuel Wemakor; Stefanie Siebenberg; José A Salas; Jae Kyung Sohng; Bernd Kammerer; Bertolt Gust
Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.
Applied and environmental microbiology 2010;76(12):4008-18.
2010: Marina Sánchez-Hidalgo; Luz Elena Núñez; Carmen Méndez; José A Salas
Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.
Antimicrobial agents and chemotherapy 2010;54(5):1684-92.
2010: Carlos Olano; Carmen Méndez; José A Salas
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis.
Natural product reports 2010;27(4):571-616.
2010: Miriam Rodríguez; Carmen Méndez; José A Salas; Gloria Blanco
Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya.
The Journal of antibiotics 2010;63(3):135-8.
2009: Carlos Olano; Cristina Gómez; María Pérez; Martina Palomino; Antonio Pineda-Lucena; RJ Carbajo; Alfredo F Braña; Carmen Méndez; José A Salas
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.
Chemistry & biology 2009;16(10):1031-44.
2009: César Sánchez; Aaroa P Salas; Alfredo F Braña; Martina Palomino; Antonio Pineda-Lucena; RJ Carbajo; Carmen Méndez; Francisco Moris; José A Salas
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles.
Chemical communications (Cambridge, England) 2009;(27):4118-20.
2009: Carlos Olano; Carmen Méndez; José A Salas
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.
Natural product reports 2009;26(5):628-60.
2009: José A Salas; Carmen Méndez
Indolocarbazole antitumour compounds by combinatorial biosynthesis.
Current opinion in chemical biology 2009;13(2):152-60.
2009: Angelina Ramos; Carlos Olano; Alfredo F Braña; Carmen Méndez; José A Salas
Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis.
Journal of bacteriology 2009;191(8):2871-5.
2009: Felipe Lombó; Mohamed S Abdelfattah; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.
Chembiochem : a European journal of chemical biology 2009;10(2):296-303.
2009: Carlos Olano; Carmen Méndez; José A Salas
Antitumor compounds from marine actinomycetes.
Marine drugs 2009;7(2):210-48.
2009: Felipe Lombó; Carlos Olano; José A Salas; Carmen Méndez
Chapter 11. Sugar biosynthesis and modification.
Methods in enzymology 2009;458():277-307.
2008: María Pérez; Irfan Baig; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.
Chembiochem : a European journal of chemical biology 2008;9(14):2295-304.
2008: Carlos Olano; Felipe Lombó; Carmen Méndez; José A Salas
Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering.
Metabolic engineering 2008;10(5):281-92.
2008: Miriam Rodríguez; Luz Elena Núñez; Alfredo F Braña; Carmen Méndez; José A Salas; Gloria Blanco
Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya.
Molecular microbiology 2008;69(3):633-45.
2008: Carlos Olano; Mohamed S Abdelfattah; Sonia Gullón; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity.
Chembiochem : a European journal of chemical biology 2008;9(4):624-33.
2008: Angelina Ramos; Felipe Lombó; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.
Microbiology (Reading, England) 2008;154(Pt 3):781-8.
2008: Irfan Baig; María Perez; Alfredo F Braña; Rohini Gomathinayagam; Chendil Damodaran; José A Salas; Carmen Méndez; Jürgen Rohr
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity.
Journal of natural products 2008;71(2):199-207.
2008: Carmen Méndez; Andriy Luzhetskyy; Andreas Bechthold; José A Salas
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern.
Current topics in medicinal chemistry 2008;8(8):710-24.
2008: Andriy Luzhetskyy; Carmen Méndez; José A Salas; Andreas Bechthold
Glycosyltransferases, important tools for drug design.
Current topics in medicinal chemistry 2008;8(8):680-709.
2007: Nuria Menéndez; Alfredo F Braña; José A Salas; Carmen Méndez
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.
Microbiology (Reading, England) 2007;153(Pt 9):3061-70.
2007: José A Salas; Carmen Méndez
Engineering the glycosylation of natural products in actinomycetes.
Trends in microbiology 2007;15(5):219-32.
2006: César Sánchez; Carmen Méndez; José A Salas
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity.
Natural product reports 2006;23(6):1007-45.
2006: Barrie Wilkinson; Matthew A Gregory; Steven J Moss; Isabelle Carletti; Rose M Sheridan; Andrew Kaja; Michael Ward; Carlos Olano; Carmen Mendez; José A Salas; Peter F Leadlay; Rob vanGinckel; Ming-Qiang Zhang
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain.
Bioorganic & medicinal chemistry letters 2006;16(22):5814-7.
2006: Felipe Lombó; Nuria Menéndez; José A Salas; Carmen Méndez
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.
Applied microbiology and biotechnology 2006;73(1):1-14.
2006: Anja Freitag; Carmen Méndez; José A Salas; Bernd Kammerer; Shu-Ming Li; Lutz Heide
Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.
Metabolic engineering 2006;8(6):653-61.
2006: Leandro M Garrido; Felipe Lombó; Irfan Baig; Mohammad Nur-e-Alam; Renata L A Furlan; Charlotte C Borda; Alfredo F Braña; Carmen Méndez; José A Salas; Jürgen Rohr; Gabriel Padilla
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.
Applied microbiology and biotechnology 2006;73(1):122-31.
2006: María Pérez; Felipe Lombó; Irfan Baig; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses.
Applied and environmental microbiology 2006;72(10):6644-52.
2006: César Sánchez; Alfredo F Braña; Carmen Méndez; José A Salas
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.
Chembiochem : a European journal of chemical biology 2006;7(8):1231-40.
2006: César Sánchez; Carmen Méndez; José A Salas
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives.
Journal of industrial microbiology & biotechnology 2006;33(7):560-8.
2006: Steven J Moss; Isabelle Carletti; Carlos Olano; Rose M Sheridan; Michael Ward; Vidya Math; Mohammad Nur-e-Alam; Alfredo F Braña; Ming Qiang Zhang; Peter F Leadlay; Carmen Méndez; José A Salas; Barrie Wilkinson
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues.
Chemical communications (Cambridge, England) 2006;(22):2341-3.
2006: Sonia Gullón; Carlos Olano; Mohamed S Abdelfattah; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.
Applied and environmental microbiology 2006;72(6):4172-83.
2006: Felipe Lombó; Ana Velasco; Angelina Castro; Fernando de la Calle; Alfredo F Braña; José M Sánchez-Puelles; Carmen Méndez; José A Salas
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species.
Chembiochem : a European journal of chemical biology 2006;7(2):366-76.
2006: Nuria Menéndez; Mohammad Nur-e-Alam; Carsten Fischer; Alfredo F Braña; José A Salas; Jürgen Rohr; Carmen Méndez
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.
Applied and environmental microbiology 2006;72(1):167-77.
2005: Aaroa P Salas; Lili Zhu; César Sánchez; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.
Molecular microbiology 2005;58(1):17-27.
2005: Mohammad Nur-e-Alam; Carmen Méndez; José A Salas; Jürgen Rohr
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.
Chembiochem : a European journal of chemical biology 2005;6(4):632-6.
2005: María Pérez; Felipe Lombó; Lili Zhu; Miranda Gibson; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins.
Chemical communications (Cambridge, England) 2005;(12):1604-6.
2005: Lili Zhu; Bohdan Ostash; Uwe Rix; Mohammad Nur-e-Alam; Almuth Mayers; Andriy Luzhetskyy; Carmen Mendez; José A Salas; Andreas Bechthold; Victor Fedorenko; Jürgen Rohr
Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
The Journal of organic chemistry 2005;70(2):631-8.
2005: César Sánchez; Lili Zhu; Alfredo F Braña; Aaroa P Salas; Jürgen Rohr; Carmen Méndez; José A Salas
Combinatorial biosynthesis of antitumor indolocarbazole compounds.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):461-6.
2005: José A Salas; Carmen Méndez
Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives.
Journal of molecular microbiology and biotechnology 2005;9(2):77-85.
2005: Carmen Méndez; José A Salas
Engineering glycosylation in bioactive compounds by combinatorial biosynthesis.
Ernst Schering Research Foundation workshop 2005;(51):127-46.
2004: Felipe Lombó; Miranda Gibson; Lisa Greenwell; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.
Chemistry & biology 2004;11(12):1709-18.
2004: Renata L A Furlan; Stephen J Watt; Leandro M Garrido; Gustavo Amarante-Mendes; Mohammad Nur-e-Alam; Jürgen Rohr; Alfredo F Braña; Carmen Mendez; José A Salas; Margaret M Sheil; Jennifer L Beck; Gabriel Padilla
DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains.
The Journal of antibiotics 2004;57(10):647-54.
2004: Felipe Lombó; Alfredo F Braña; José A Salas; Carmen Méndez
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.
Chembiochem : a European journal of chemical biology 2004;5(9):1181-7.
2004: Nuria Menéndez; Mohammad Nur-e-Alam; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.
Molecular microbiology 2004;53(3):903-15.
2004: José A Salas
Novel mechanism for priming aromatic polyketide synthases.
Chemistry & biology 2004;11(7):892-4.
2004: Carlos Olano; Steven J Moss; Alfredo F Braña; Rose M Sheridan; Vidya Math; Alison J Weston; Carmen Méndez; Peter F Leadlay; Barrie Wilkinson; José A Salas
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation.
Molecular microbiology 2004;52(6):1745-56.
2004: Bohdan Ostash; Uwe Rix; Lily L Remsing Rix; Tao Liu; Felipe Lombo; Andriy Luzhetskyy; Oleksandr Gromyko; Chenchen Wang; Alfredo F Braña; Carmen Méndez; José A Salas; Victor Fedorenko; Jürgen Rohr
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.
Chemistry & biology 2004;11(4):547-55.
2004: David Rodríguez; Luis M Quirós; José A Salas
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.
The Journal of biological chemistry 2004;279(9):8149-58.
2004: Carlos Olano; Barrie Wilkinson; César Sánchez; Steven J Moss; Rose Sheridan; Vidya Math; Alison J Weston; Alfredo F Braña; Christine J Martin; Markiyan Oliynyk; Carmen Méndez; Peter F Leadlay; José A Salas
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions.
Chemistry & biology 2004;11(1):87-97.
2004: Nuria Menéndez; Mohammad Nur-e-Alam; Alfredo F Braña; Jürgen Rohr; José A Salas; Carmen Méndez
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.
Chemistry & biology 2004;11(1):21-32.
2003: Carlos Olano; Barrie Wilkinson; Steven J Moss; Alfredo F Braña; Carmen Méndez; Peter F Leadlay; José A Salas
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Chemical communications (Cambridge, England) 2003;(22):2780-2.
2003: Carmen Méndez; José A Salas
On the generation of novel anticancer drugs by recombinant DNA technology: the use of combinatorial biosynthesis to produce novel drugs.
Combinatorial chemistry & high throughput screening 2003;6(6):513-26.
2003: David Rodríguez; Luis M Quirós; Alfredo F Braña; José A Salas
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.
Journal of bacteriology 2003;185(13):3962-5.
2003: Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Dirk Hoffmeister; A Brana; Carmen Mendez; José A Salas; Andreas Bechthold; Victor Fedorenko
Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.
FEMS microbiology letters 2003;222(1):149-53.
2003: Lily L Remsing; Ana M González; Mohammad Nur-e-Alam; M José Fernández-Lozano; Alfredo F Braña; Uwe Rix; marcos oliveira; Carmen Méndez; José A Salas; Jürgen Rohr
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.
Journal of the American Chemical Society 2003;125(19):5745-53.
2003: Luz Elena Núñez; Carmen Méndez; Alfredo F Braña; Gloria Blanco; José A Salas
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya.
Chemistry & biology 2003;10(4):301-11.
2002: Carsten Fischer; Leticia Rodríguez; Eugenio P Patallo; Fredilyn Lipata; Alfredo F Braña; Carmen Méndez; José A Salas; Jürgen Rohr
Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.
Journal of natural products 2002;65(11):1685-9.
2002: Leticia Rodríguez; Ignacio Aguirrezabalaga; Nerea Allende; Alfredo F Braña; Carmen Méndez; José A Salas
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds.
Chemistry & biology 2002;9(6):721-9.
2002: Axel Trefzer; Gloria Blanco; Lily L Remsing; Eva Künzel; Uwe Rix; Fredilyn Lipata; Alfredo F Braña; Carmen Méndez; Jürgen Rohr; Andreas Bechthold; José A Salas
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.
Journal of the American Chemical Society 2002;124(21):6056-62.
2002: Carmen Méndez; Eva Künzel; Fredilyn Lipata; Felipe Lombó; William E Cotham; Michael D Walla; Daniel W Bearden; Alfredo F Braña; José A Salas; Jürgen Rohr
Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891.
Journal of natural products 2002;65(5):779-82.
2002: César Sánchez; Igor A Butovich; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.
Chemistry & biology 2002;9(4):519-31.
2002: Paul F Long; Christopher J Wilkinson; Christian P Bisang; Jesús Cortés; Nicholas Dunster; Markiyan Oliynyk; Ellen McCormick; Hamish McArthur; Carmen Mendez; José A Salas; James Staunton; Peter F Leadlay
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase.
Molecular microbiology 2002;43(5):1215-25.
2002: Lily L Remsing; Jose Garcia-Bernardo; Ana Gonzalez; Eva Künzel; Uwe Rix; Alfredo F Braña; Daniel W Bearden; Carmen Méndez; José A Salas; Jürgen Rohr
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.
Journal of the American Chemical Society 2002;124(8):1606-14.
2001: Carmen Méndez; José A Salas
Altering the glycosylation pattern of bioactive compounds.
Trends in biotechnology 2001;19(11):449-56.
2001: L Rodríguez; David Rodríguez; Carlos Olano; Alfredo F Braña; Carmen Méndez; José A Salas
Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus.
Journal of bacteriology 2001;183(18):5358-63.
2001: Eugenio P Patallo; Gloria Blanco; Carsten Fischer; A F Brana; Jürgen Rohr; C Mendez; José A Salas
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
The Journal of biological chemistry 2001;276(22):18765-74.
2001: Carmen Méndez; José A Salas
The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms.
Research in microbiology 2001;152(3-4):341-50.
2001: Gloria Blanco; Eugenio P Patallo; Alfredo F Braña; Axel Trefzer; Andreas Bechthold; Jürgen Rohr; Carmen Méndez; José A Salas
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
Chemistry & biology 2001;8(3):253-63.
2001: Gabriele Weitnauer; Sabine Gaisser; Axel Trefzer; Sigrid Stockert; Lucia Westrich; L M Quiros; C Mendez; José A Salas; Andreas Bechthold
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57.
Antimicrobial agents and chemotherapy 2001;45(3):690-5.
2001: A González; Lily L Remsing; Felipe Lombó; M J Fernández; L Prado; Alfredo F Braña; Eva Künzel; Jürgen Rohr; Carmen Méndez; José A Salas
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.
Molecular & general genetics : MGG 2001;264(6):827-35.
2000: Carmen Méndez; Gabriele Weitnauer; Andreas Bechthold; José A Salas
Structure alteration of polyketides by recombinant DNA technology in producer organisms--prospects for the generation of novel pharmaceutical drugs.
Current pharmaceutical biotechnology 2000;1(4):355-95.
2000: Luis M Quirós; RJ Carbajo; José A Salas
Inversion of the anomeric configuration of the transferred sugar during inactivation of the macrolide antibiotic oleandomycin catalyzed by a macrolide glycosyltransferase.
FEBS letters 2000;476(3):186-9.
2000: L Rodriguez; C Oelkers; Ignacio Aguirrezabalaga; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways.
Journal of molecular microbiology and biotechnology 2000;2(3):271-6.
2000: Jose Garcia-Bernardo; Alfredo F Braña; Carmen Méndez; José A Salas
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.
FEMS microbiology letters 2000;186(1):61-5.
2000: Ignacio Aguirrezabalaga; Carlos Olano; N Allende; L Rodriguez; Alfredo F Braña; Carmen Méndez; José A Salas
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
Antimicrobial agents and chemotherapy 2000;44(5):1266-75.
2000: Luis M Quirós; RJ Carbajo; Alfredo F Braña; José A Salas
Glycosylation of macrolide antibiotics. Purification and kinetic studies of a macrolide glycosyltransferase from Streptomyces antibioticus.
The Journal of biological chemistry 2000;275(16):11713-20.
2000: M J Lozano; Lily L Remsing; Luis M Quirós; Alfredo F Braña; E Fernández; C Sánchez; Carmen Méndez; Jürgen Rohr; José A Salas
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.
The Journal of biological chemistry 2000;275(5):3065-74.
2000: Gloria Blanco; E Fernández; M J Fernández; Alfredo F Braña; U Weissbach; Eva Künzel; Jürgen Rohr; Carmen Méndez; José A Salas
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.
Molecular & general genetics : MGG 2000;262(6):991-1000.
1999: M Doumith; R Legrand; C Lang; José A Salas; MC Raynal
Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives.
Molecular microbiology 1999;34(5):1039-48.
1999: Axel Trefzer; José A Salas; Andreas Bechthold
Genes and enzymes involved in deoxysugar biosynthesis in bacteria.
Natural product reports 1999;16(3):283-99.
1999: L Prado; Felipe Lombó; Alfredo F Braña; Carmen Méndez; Jürgen Rohr; José A Salas
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.
Molecular & general genetics : MGG 1999;261(2):216-25.
1999: S E Wohlert; Eva Künzel; R Machinek; Carmen Méndez; José A Salas; Jürgen Rohr
The structure of mithramycin reinvestigated.
Journal of natural products 1999;62(1):119-21.
1999: L Prado; E Fernández; U Weissbach; Gloria Blanco; Luis M Quirós; Alfredo F Braña; Carmen Méndez; Jürgen Rohr; José A Salas
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.
Chemistry & biology 1999;6(1):19-30.
1999: Felipe Lombó; Alfredo F Braña; Carmen Méndez; José A Salas
The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.
Journal of bacteriology 1999;181(2):642-7.
1998: José A Salas; Carmen Méndez
Genetic manipulation of antitumor-agent biosynthesis to produce novel drugs.
Trends in biotechnology 1998;16(11):475-82.
1998: E Fernández; U Weissbach; C Sánchez Reillo; Alfredo F Braña; Carmen Méndez; Jürgen Rohr; José A Salas
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.
Journal of bacteriology 1998;180(18):4929-37.
1998: Carlos Olano; A M Rodriguez; JM Michel; Carmen Méndez; MC Raynal; José A Salas
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.
Molecular & general genetics : MGG 1998;259(3):299-308.
1998: Luis M Quirós; Ignacio Aguirrezabalaga; Carlos Olano; Carmen Méndez; José A Salas
Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus.
Molecular microbiology 1998;28(6):1177-85.
1998: Carmen Méndez; José A Salas
ABC transporters in antibiotic-producing actinomycetes.
FEMS microbiology letters 1998;158(1):1-8.
1997: C Sanchez; Gloria Blanco; C Mendez; José A Salas
Cloning, sequencing and transcriptional analysis of a Streptomyces coelicolor operon containing the rplM and rpsI genes encoding ribosomal proteins ScoL13 and ScoS9.
Molecular & general genetics : MGG 1997;257(1):91-6.
1997: Felipe Lombó; Karsten Siems; Alfredo F Braña; Carmen Méndez; KU Bindseil; José A Salas
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.
Journal of bacteriology 1997;179(10):3354-7.
1997: A Buche; Carmen Méndez; José A Salas
Interaction between ATP, oleandomycin and the OleB ATP-binding cassette transporter of Streptomyces antibioticus involved in oleandomycin secretion.
The Biochemical journal 1997;321 ( Pt 1)():139-44.
1996: Carlos Olano; A M Rodriguez; Carmen Méndez; José A Salas
Topological studies of the membrane component of the OleC ABC transporter involved in oleandomycin resistance in Streptomyces antibioticus.
FEMS microbiology letters 1996;143(2-3):133-9.
1996: G Aparicio; A Buche; Carmen Méndez; José A Salas
Characterization of the ATPase activity of the N-terminal nucleotide binding domain of an ABC transporter involved in oleandomycin secretion by Streptomyces antibioticus.
FEMS microbiology letters 1996;141(2-3):157-62.
1996: E Fernández; Felipe Lombó; Carmen Méndez; José A Salas
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.
Molecular & general genetics : MGG 1996;251(6):692-8.
1996: Felipe Lombó; Gloria Blanco; E Fernández; Carmen Méndez; José A Salas
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
Gene 1996;172(1):87-91.
1996: Gloria Blanco; H Fu; C Mendez; C Khosla; José A Salas
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.
Chemistry & biology 1996;3(3):193-6.
1995: Luis M Quirós; José A Salas
Biosynthesis of the macrolide oleandomycin by Streptomyces antibioticus. Purification and kinetic characterization of an oleandomycin glucosyltransferase.
The Journal of biological chemistry 1995;270(31):18234-9.
1995: Carlos Olano; A M Rodríguez; Carmen Méndez; José A Salas
A second ABC transporter is involved in oleandomycin resistance and its secretion by Streptomyces antibioticus.
Molecular microbiology 1995;16(2):333-43.
1995: A M Rodriguez; Carlos Olano; Carmen Méndez; C Richard Hutchinson; José A Salas
A cytochrome P450-like gene possibly involved in oleandomycin biosynthesis by Streptomyces antibioticus.
FEMS microbiology letters 1995;127(1-2):117-20.
1994: Luis M Quirós; C Hernández; José A Salas
Purification and characterization of an extracellular enzyme from Streptomyces antibioticus that converts inactive glycosylated oleandomycin into the active antibiotic.
European journal of biochemistry / FEBS 1994;222(1):129-35.
1994: G Blanco; M Rosario Rodicio; A M Puglia; Carmen Méndez; C J Thompson; José A Salas
Synthesis of ribosomal proteins during growth of Streptomyces coelicolor.
Molecular microbiology 1994;12(3):375-85.
1994: José A Salas; C Hernández; Carmen Méndez; Carlos Olano; Luis M Quirós; A M Rodríguez; C Vilches
Intracellular glycosylation and active efflux as mechanisms for resistance to oleandomycin in Streptomyces antibioticus, the producer organism.
Microbiología (Madrid, Spain) 1994;10(1-2):37-48.
1994: D G Swan; A M Rodríguez; C Vilches; Carmen Méndez; José A Salas
Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.
Molecular & general genetics : MGG 1994;242(3):358-62.
1993: Gloria Blanco; A Pereda; P Brian; Carmen Méndez; Keith F Chater; José A Salas
A hydroxylase-like gene product contributes to synthesis of a polyketide spore pigment in Streptomyces halstedii.
Journal of bacteriology 1993;175(24):8043-8.
1993: C Hernández; Carlos Olano; Carmen Méndez; José A Salas
Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation.
Gene 1993;134(1):139-40.
1993: Gloria Blanco; P Brian; A Pereda; Carmen Méndez; José A Salas; Keith F Chater
Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.
Gene 1993;130(1):107-16.
1993: A M Rodríguez; Carlos Olano; C Vilches; Carmen Méndez; José A Salas
Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily.
Molecular microbiology 1993;8(3):571-82.
1992: Luis M Quirós; Francisco Parra; José A Salas
Changes in ribosomal proteins during colony development in Streptomyces.
Canadian journal of microbiology 1992;38(12):1260-3.
1992: Gloria Blanco; Francisco Parra; Carmen Méndez; José A Salas
The nucleotide sequence of the L10 equivalent ribosomal protein gene of Streptomyces antibioticus.
Nucleic acids research 1992;20(19):5223.
1992: Francisco Parra; Gloria Blanco; José M Martín-Alonso; Milagros Balbín; Carmen Méndez; José A Salas
Cloning and sequence of a gene encoding the L7/L12 ribosomal protein equivalent of Streptomyces antibioticus.
Gene 1992;118(1):127-9.
1992: Gloria Blanco; A Pereda; Carmen Méndez; José A Salas
Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment.
Gene 1992;112(1):59-65.
1992: C Vilches; C Hernandez; C Mendez; José A Salas
Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.
Journal of bacteriology 1992;174(1):161-5.
1990: C Vilches; Carmen Méndez; C Hardisson; José A Salas
Biosynthesis of oleandomycin by Streptomyces antibioticus: influence of nutritional conditions and development of resistance.
Journal of general microbiology 1990;136(8):1447-54.
1989: J Fernando Fierro; C Vilches; C Hardisson; José A Salas
Streptogramins-inactivating activity in three producer streptomycetes.
FEMS microbiology letters 1989;49(2-3):243-6.
1988: L M Quiros; S Fidalgo; F J Mendez; C Hardisson; José A Salas
Novel mechanisms of resistance to lincosamides in Staphylococcus and Arthrobacter spp.
Antimicrobial agents and chemotherapy 1988;32(4):420-5.
1988: Jose-Fernando Fierro; C Hardisson; José A Salas
Involvement of cell impermeability in resistance to macrolides in some producer streptomycetes.
The Journal of antibiotics 1988;41(1):142-4.
1988: S Fidalgo; F J Mendez; C Hardisson; José A Salas
Epidemiology of macrolide and lincosamide resistance in species of staphylococci in a general hospital.
The Journal of hospital infection 1988;11(1):36-43.
1987: Jose-Fernando Fierro; C Hardisson; José A Salas
Resistance to oleandomycin in Streptomyces antibioticus, the producer organism.
Journal of general microbiology 1987;133(7):1931-9.
1986: J Roza; M G Blanco; C Hardisson; José A Salas
Self-resistance in actinomycetes producing inhibitors of RNA polymerase.
The Journal of antibiotics 1986;39(4):609-12.
1986: Luis M Quirós; C Hardisson; José A Salas
Isolation and properties of Streptomyces spore membranes.
Journal of bacteriology 1986;165(3):923-8.
1985: J Llaneza; C J Villar; José A Salas; J E Suarez; M Carmen Mendoza; C Hardisson
Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.
Antimicrobial agents and chemotherapy 1985;28(1):163-4.
1984: M G Blanco; C Hardisson; José A Salas
Resistance in inhibitors of RNA polymerase in actinomycetes which produce them.
Journal of general microbiology 1984;130(11):2883-91.
1983: José A Salas; J A Guijarro; C Hardisson
High calcium content in Streptomyces spores and its release as an early event during spore germination.
Journal of bacteriology 1983;155(3):1316-23.
1983: J A Guijarro; J E Suarez; José A Salas; C Hardisson
Pattern of protein degradation during germination of Streptomyces antibioticus spores.
Canadian journal of microbiology 1983;29(6):637-43.