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Julia Skokowa

Research Profile

Chemicals & Drugs

Disorders

Neutropenia

Living Beings

Anatomy

Physiology

Mutation

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Publications

TOP 3
Julia Skokowa; Karl Welte
Defective G-CSFR signaling pathways in congenital neutropenia.
Julia Skokowa; Claudio Sustmann; Cornelia Zeidler; Janis Burkhardt; Esteban Carrizosa; Arnold Ganser; Rudolf Grosschedl; Kshama Gupta; Kais Hussein; Olga Klimenkova; Maxim Klimiankou; Hans-Heinrich Kreipe; Inna Kusnetsova; Dan Lan; Zhixiong Li; Karl Welte
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Basant Kumar Thakur; Prakash Chandra; Tino Dittrich; Yannick Lippka; Julia Skokowa; Karl Welte
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.

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All Publications

2013: Julia Skokowa; Karl Welte
Defective G-CSFR signaling pathways in congenital neutropenia.
Hematology/oncology clinics of North America 2013;27(1):75-88, viii.
2012: Julia Skokowa; Claudio Sustmann; Cornelia Zeidler; Janis Burkhardt; Esteban Carrizosa; Arnold Ganser; Rudolf Grosschedl; Kshama Gupta; Kais Hussein; Olga Klimenkova; Maxim Klimiankou; Hans-Heinrich Kreipe; Inna Kusnetsova; Dan Lan; Zhixiong Li; Karl Welte
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Nature medicine 2012;18(10):1550-9.
2012: Basant Kumar Thakur; Prakash Chandra; Tino Dittrich; Yannick Lippka; Julia Skokowa; Karl Welte
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.
Biochemical and biophysical research communications 2012;420(4):714-20.
2012: Lan Dan; Olga Klimenkova; Maxim Klimiankou; Jan-Henning Klusman; Dirk Reinhardt; Marry M van den Heuvel-Eibrink; Karl Welte; Julia Skokowa
The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells.
Haematologica 2012;97(4):551-9.
2012: Lutz Zeidler; Martin Zimmermann; Andrea Teigler-Schlegel; Christoph Tschan; Karl Welte; Dorothee Bartels; Claus R Bartram; Gunnar Cario; Lilia Goudeva; Sarah Jäger; Rolf Koehler; Wolf-Dieter Ludwig; Barbara Meissner; Anja Möricke; Richard Ratei; Hansjörg Riehm; Martin Schrappe; André Schrauder; Julia Skokowa; Martin Stanulla
Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome.
Haematologica 2012;97(3):402-9.
2009: Julia Skokowa; John Paul Fobiwe; Lan Dan; Basant Kumar Thakur; Karl Welte
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.
Blood 2009;114(14):3044-51.
2009: Julia Skokowa; Karl Welte
Dysregulation of myeloid-specific transcription factors in congenital neutropenia.
Annals of the New York Academy of Sciences 2009;1176():94-100.
2009: Julia Skokowa; Dan Lan; Basant Kumar Thakur; Fei Wang; Kshama Gupta; Gunnar Cario; Annette Müller Brechlin; Axel Schambach; Lars Hinrichsen; Gustav Meyer; Matthias Gaestel; Martin Stanulla; Qiang Tong; Karl Welte
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.
Nature medicine 2009;15(2):151-8.
2008: Manuela Germeshausen; Julia Skokowa; Matthias Ballmaier; Cornelia Zeidler; Karl Welte
G-CSF receptor mutations in patients with congenital neutropenia.
Current opinion in hematology 2008;15(4):332-7.
2007: Gunnar Cario; Shai Izraeli; Anja Teichert; Peter Rhein; Julia Skokowa; Anja Möricke; Martin Zimmermann; André Schrauder; Leonid Karawajew; Wolf-Dieter Ludwig; Karl Welte; Holger J Schünemann; Brigitte Schlegelberger; Martin Schrappe; Martin Stanulla
High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4813-20.
2007: Julia Skokowa; Karl Welte
LEF-1 is a decisive transcription factor in neutrophil granulopoiesis.
Annals of the New York Academy of Sciences 2007;1106():143-51.
2007: Julia Skokowa; Manuela Germeshausen; Cornelia Zeidler; Karl Welte
Severe congenital neutropenia: inheritance and pathophysiology.
Current opinion in hematology 2007;14(1):22-8.
2006: Julia Skokowa; Gunnar Cario; Murat Uenalan; Axel Schambach; Manuela Germeshausen; Karin Battmer; Cornelia Zeidler; Ulrich Lehmann; Matthias Eder; Christopher Baum; Rudolf Grosschedl; Martin Stanulla; Michaela Scherr; Karl Welte
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia.
Nature medicine 2006;12(10):1191-7.
2006: Johannes Leonhardt; Martin Stanulla; Reinhard von Wasielewski; Julia Skokowa; Joachim F Kübler; Benno M Ure; Claus Petersen
Gene expression profile of the infective murine model for biliary atresia.
Pediatric surgery international 2006;22(1):84-9.
2005: Zheng Wang; Julia Skokowa; Andri Pramono; Matthias Ballmaier; Karl Welte
Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells.
Annals of the New York Academy of Sciences 2005;1044():29-40.
2005: Gunnar Cario; Julia Skokowa; Zheng Wang; Vesna Bucan; Cornelia Zeidler; Martin Stanulla; Martin Schrappe; Karl Welte
Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor.
British journal of haematology 2005;129(2):275-8.
2005: Julia Skokowa; Syed R Ali; Olga Felda; Varsha Kumar; Stephanie Konrad; Nelli Shushakova; Reinhold E Schmidt; Roland P Piekorz; Bernd Nürnberg; Karsten Spicher; Lutz Birnbaumer; Jörg Zwirner; Jill W C Claassens; Sjef Verbeek; Nico van Rooijen; Jörg Köhl; J Engelbert Gessner
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):3041-50.
2002: Nelli Shushakova; Julia Skokowa; Jurriaan Schulman; Ulrich Baumann; Jörg Zwirner; Reinhold E Schmidt; J Engelbert Gessner
C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease.
The Journal of clinical investigation 2002;110(12):1823-30.
2002: Heinfried Radeke; Iska Janssen-Graalfs; Eveline N Sowa; Nelli Chouchakova; Julia Skokowa; Fabian Löscher; Reinhold E Schmidt; Peter Heeringa; J Engelbert Gessner
Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis.
The Journal of biological chemistry 2002;277(30):27535-44.
2002: Anke Lührmann; Ursula Deiters; Julia Skokowa; Michaela Hanke; J Engelbert Gessner; Peter F Mühlradt; Reinhard Pabst; Thomas Tschernig
In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application.
Infection and immunity 2002;70(7):3785-92.
2001: Nelli Chouchakova; Julia Skokowa; Ulrich Baumann; Thomas Tschernig; K M Philippens; Bernhard Nieswandt; Reinhold E Schmidt; J Engelbert Gessner
Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5193-200.