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Prakash Hande

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Aik Kia Khaw; Guruprasad Kalthur; M Pradeepa Hande; M Prakash Hande
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.
Aik Kia Khaw; Jacklyn Wei Yan Yong; Guruprasad Kalthur; M Prakash Hande
Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells.
Caroline F Bull; M Prakash Hande; Graham Mayrhofer; Grace Low Kah Mun; Dimphy Zeegers; Michael F Fenech
Folate deficiency is associated with the formation of complex nuclear anomalies in the cytokinesis-block micronucleus cytome assay.

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All Publications

2013: Aik Kia Khaw; Guruprasad Kalthur; M Pradeepa Hande; M Prakash Hande
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.
Journal of cellular biochemistry 2013;114(6):1257-70.
2012: Aik Kia Khaw; Jacklyn Wei Yan Yong; Guruprasad Kalthur; M Prakash Hande
Genistein induces growth arrest and suppresses telomerase activity in brain tumor cells.
Genes, chromosomes & cancer 2012;51(10):961-74.
2012: Caroline F Bull; M Prakash Hande; Graham Mayrhofer; Grace Low Kah Mun; Dimphy Zeegers; Michael F Fenech
Folate deficiency is associated with the formation of complex nuclear anomalies in the cytokinesis-block micronucleus cytome assay.
Environmental and molecular mutagenesis 2012;53(4):311-23.
2012: Shruti Pavagadhi; Armah A de la Cruz; Dionysios D Dionysiou; Zhiyuan Gong; M Prakash Hande; Rajasekhar Balasubramanian
Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: a balneation study.
Aquatic toxicology (Amsterdam, Netherlands) 2012;109():1-10.
2012: Jacklyn W Y Yong; Xiujun Yeo; Md Matiullah Khan; Martin B Lee; M Prakash Hande
Stable expression of promyelocytic leukaemia (PML) protein in telomerase positive MCF7 cells results in alternative lengthening of telomeres phenotype.
Genome integrity 2012;3(1):5.
2012: Hui Kheng Lim; P V Asharani; M Prakash Hande
Enhanced genotoxicity of silver nanoparticles in DNA repair deficient Mammalian cells.
Frontiers in genetics 2012;3():104.
2012: Pv Asharani; Ganapathy Balaji; Hui Kheng Lim; Swaminathan Sethu; Suresh Valiyaveettil; M Prakash Hande
Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells.
Genome integrity 2012;3(1):2.
2011: Jasmine J Li; Soo-Ling Lo; Cheng-Teng Ng; Resham Lal Gurung; Deny Hartono; M Prakash Hande; Choon-Nam Ong; Boon-Huat Bay; Lin Yue Lanry Yung
Genomic instability of gold nanoparticle treated human lung fibroblast cells.
Biomaterials 2011;32(23):5515-23.
2011: Yiwei Teow; P V Asharani; M Prakash Hande; Suresh Valiyaveettil
Health impact and safety of engineered nanomaterials.
Chemical communications (Cambridge, England) 2011;47(25):7025-38.
2011: Samah El Ghamrasni; Ashwin Pamidi; Marie Jo Halaby; Miyuki Bohgaki; Renato Cardoso; Li Li; Shriram Venkatesan; Swaminathan Sethu; Atsushi Hirao; Tak W Mak; M Prakash Hande; Anne Hakem; Raza Hakem
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
PLoS genetics 2011;7(5):e1001385.
2011: Toshiyuki Bohgaki; Miyuki Bohgaki; Renato Cardoso; Stephanie Panier; Dimphy Zeegers; Li Li; Grant S Stewart; Otto Sanchez; M Prakash Hande; Daniel Durocher; Anne Hakem; Razqallah Hakem
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
PLoS genetics 2011;7(4):e1001381.
2010: Hiroyuki Niida; Kazuhiro Murata; Midori Shimada; Kumiko Ogawa; Kumiko Ohta; Kyoko Suzuki; Hidetsugu Fujigaki; Aik Kia Khaw; Birendranath Banerjee; M Prakash Hande; Tomomi Miyamoto; Ichiro Miyoshi; Tomoyuki Shirai; Noboru Motoyama; Mireille Delhase; Ettore Appella; Makoto Nakanishi
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.
The EMBO journal 2010;29(20):3558-70.
2010: Chui-Yee Fong; Arjunan Subramanian; Arijit Biswas; Kalamegam Gauthaman; Prarthana Srikanth; M Prakash Hande; Ariff Bongso
Derivation efficiency, cell proliferation, freeze-thaw survival, stem-cell properties and differentiation of human Wharton's jelly stem cells.
Reproductive biomedicine online 2010;21(3):391-401.
2010: Sunitha Nair; M Prakash Hande; Lina Lim
Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage.
Cancer letters 2010;294(1):111-7.
2010: Xin Fu; Wei Seong Toh; Hua Liu; Kai Lu; Mingming Li; M Prakash Hande; tong cao
Autologous feeder cells from embryoid body outgrowth support the long-term growth of human embryonic stem cells more effectively than those from direct differentiation.
Tissue engineering. Part C, Methods 2010;16(4):719-33.
2010: Manikandan Jayapal; Rabindra N Bhattacharjee; Alirio J Melendez; M Prakash Hande
Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins.
The international journal of biochemistry & cell biology 2010;42(2):230-40.
2010: Kalpana Gopalakrishnan; Grace Kah Mun Low; Aloysius Poh Leong Ting; Prarthana Srikanth; Predrag Slijepcevic; M Prakash Hande
Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells.
Genome integrity 2010;1(1):16.
2010: Resham Lal Gurung; Shi Ni Lim; Aik Kia Khaw; Jasmine Fen Fen Soon; Kirthan Shenoy; Safiyya Mohamed Ali; Manikandan Jayapal; Swaminathan Sethu; Rajamanickam Baskar; M Prakash Hande
Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.
PloS one 2010;5(8):e12124.
2010: Rabindra N Bhattacharjee; Birendranath Banerjee; Shizuo Akira; M Prakash Hande
Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.
PloS one 2010;5(7):e11873.
2010: Helena Mistry; Laura Tamblyn; Hussein Butt; Daniel Sisgoreo; Aileen Gracias; Meghan Larin; Kalpana Gopalakrishnan; M Prakash Hande; John Peter McPherson
UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation.
Genome integrity 2010;1(1):7.
2010: Resham Lal Gurung; Lakshmidevi Balakrishnan; Rabindra N Bhattacharjee; Manikandan Jayapal; Srividya Swaminathan; M Prakash Hande
Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.
Genome integrity 2010;1(1):5.
2010: Razqallah Hakem; M Prakash Hande; John H J Petrini; Predrag Slijepcevic
Genome Integrity - a new open access journal.
Genome integrity 2010;1(1):1.
2010: P V Asharani; Ng Xinyi; M Prakash Hande; Suresh Valiyaveettil
DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles.
Nanomedicine (London, England) 2010;5(1):51-64.
2010: Aloysius Poh Leong Ting; Grace Kah Mun Low; Kalpana Gopalakrishnan; M Prakash Hande
Telomere attrition and genomic instability in xeroderma pigmentosum type-b deficient fibroblasts under oxidative stress.
Journal of cellular and molecular medicine 2010;14(1-2):403-16.
2009: Rajamanickam Baskar; M Prakash Hande
A comparative study of protein kinase C activation in gamma-irradiated proliferating and confluent human lung fibroblast cells.
Journal of radiation research 2009;50(5):415-23.
2009: P V AshaRani; Grace Low Kah Mun; M Prakash Hande; Suresh Valiyaveettil
Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
ACS nano 2009;3(2):279-90.
2009: Laura Tamblyn; Erica Li; Haya Sarras; Prarthana Srikanth; M Prakash Hande; John Peter McPherson
A role for Mus81 in the repair of chromium-induced DNA damage.
Mutation research 2009;660(1-2):57-65.
2009: P V Asharani; M Prakash Hande; Suresh Valiyaveettil
Anti-proliferative activity of silver nanoparticles.
BMC cell biology 2009;10():65.
2009: Yuk-Kien Chong; Tan-Boon Toh; Norazean Zaiden; Anuradha Poonepalli; Siew Hong Leong; Catherine Ee Ling Ong; Yiting Yu; Patrick B Tan; Siew-Ju See; Wai-Hoe Ng; Ivan Ng; M Prakash Hande; Oi Lian Kon; Beng-Ti Ang; Carol Tang
Cryopreservation of neurospheres derived from human glioblastoma multiforme.
Stem cells (Dayton, Ohio) 2009;27(1):29-39.
2008: Anuradha Poonepalli; Birendranath Banerjee; Kalpana Ramnarayanan; Nallasivam Palanisamy; Thomas Choudary Putti; M Prakash Hande
Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer.
Genes, chromosomes & cancer 2008;47(12):1098-109.
2008: Chizuru Tsuruoka; Masao Suzuki; M Prakash Hande; Yoshiya Furusawa; Kazunori Anzai; Ryuichi Okayasu
The difference in LET and ion species dependence for induction of initially measured and non-rejoined chromatin breaks in normal human fibroblasts.
Radiation research 2008;170(2):163-71.
2008: Kumar Jayaseelan Vinoth; Boon Chin Heng; Anuradha Poonepalli; Birendranath Banerjee; Lakshmidevi Balakrishnan; Kai Lu; M Prakash Hande; tong cao
Human embryonic stem cells may display higher resistance to genotoxic stress as compared to primary explanted somatic cells.
Stem cells and development 2008;17(3):599-607.
2008: Jennifer P A Newman; Birendranath Banerjee; Wanru Fang; Anuradha Poonepalli; Lakshmidevi Balakrishnan; Grace Kah Mun Low; Rabindra N Bhattacharjee; Shizuo Akira; Manikandan Jayapal; Alirio J Melendez; Rajamanickam Baskar; Han-Woong Lee; M Prakash Hande
Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells.
Journal of cellular physiology 2008;214(3):796-809.
2008: B Banerjee; D N Peiris; S H Koo; PAUL CHUI; E J D Lee; M Prakash Hande
Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victims.
Cytogenetic and genome research 2008;122(3-4):350-5.
2008: Grace Kah Mun Low; Edwin Dan Zhihao Fok; Aloysius Poh Leong Ting; M Prakash Hande
Oxidative damage induced genotoxic effects in human fibroblasts from Xeroderma Pigmentosum group A patients.
The international journal of biochemistry & cell biology 2008;40(11):2583-95.
2008: Rajamanickam Baskar; Adayabalam S Balajee; Charles R Geard; M Prakash Hande
Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells.
The international journal of biochemistry & cell biology 2008;40(1):125-34.
2008: Birendranath Banerjee; Sanjiv Sharma; Sridevi Hegde; M Prakash Hande
Analysis of telomere damage by fluorescence in situ hybridisation on micronuclei in lymphocytes of breast carcinoma patients after radiotherapy.
Breast cancer research and treatment 2008;107(1):25-31.
2007: Jingsong Li; Jing Tan; Li Zhuang; Birendranath Banerjee; Xiaojing Yang; Jenny Fung Ling Chau; Puay Leng Lee; M Prakash Hande; Baojie Li; Qiang Yu
Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress.
Cancer research 2007;67(23):11317-26.
2007: Aik Kia Khaw; Miranti Silasudjana; Birendranath Banerjee; Masao Suzuki; Rajamanickam Baskar; M Prakash Hande
Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells.
Mutation research 2007;625(1-2):134-44.
2007: Francis Chee Kuan Tan; Kong Heng Lee; Sok-Siam Gouk; Raquel Magalhaes; Anuradha Poonepalli; M Prakash Hande; Gavin Dawe; Lilia L Kuleshova
Optimization of cryopreservation of stem cells cultured as neurospheres: comparison between vitrification, slow-cooling and rapid cooling freezing protocols.
Cryo letters 2007;28(6):445-60.
2007: Lee-Yee Choong; Jamie Lim; Marie Loh; Xiaohui Man; Yunhao Chen; Weiyi Toy; Mengfei Pan; Chien-Shing Chen; Anuradha Poonepalli; M Prakash Hande; Puay Hoon Tan; Manuel Salto-Tellez; Chow-Yin Wong; Nilesh Shah; Brian J Druker; Yoon Pin Lim
Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics.
Molecular cancer therapeutics 2007;6(11):2828-42.
2007: Jianli Wang; Yu-Xin Liu; M Prakash Hande; Alan C Wong; Yan J Jin; Yuxin Yin
TAp73 is a downstream target of p53 in controlling the cellular defense against stress.
The Journal of biological chemistry 2007;282(40):29152-62.
2007: Ashwin Pamidi; Renato Cardoso; Anne Hakem; Elzbieta Matysiak-Zablocki; Anuradha Poonepalli; Laura Tamblyn; Bayardo Perez-Ordonez; M Prakash Hande; Otto H Sanchez; Raza Hakem
Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Cancer research 2007;67(18):8527-35.
2007: Birendranath Banerjee; H S Vadiraj; Amrit Ram; Raghavendra Rao; Manikandan Jayapal; Kodaganur S Gopinath; B S Ramesh; Nalini Rao; Ajay Kumar; Nagarathna Raghuram; Sridevi Hegde; Hongasandra Rama Rao Nagendra; M Prakash Hande
Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy.
Integrative cancer therapies 2007;6(3):242-50.
2007: Siyuan Zhang; Y Lin; Y-S Kim; M Prakash Hande; Z-G Liu; Han-Ming Shen
c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation.
Cell death and differentiation 2007;14(5):1001-10.
2007: Hiroyuki Niida; Yuko Katsuno; Birendranath Banerjee; M Prakash Hande; Makoto Nakanishi
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.
Molecular and cellular biology 2007;27(7):2572-81.
2006: Koichi Akiyama; Kosuke Yusa; Hideharu Hashimoto; Anuradha Poonepalli; M Prakash Hande; Naoki Kakazu; Junji Takeda; Makoto Tachibana; Yoichi Shinkai
Rad54 is dispensable for the ALT pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(11):1305-15.
2006: Sofia Francia; Robert S Weiss; M Prakash Hande; Raimundo Freire; Fabrizio d'Adda di Fagagna
Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex.
Current biology : CB 2006;16(15):1551-8.
2006: Debasish Roy; Gloria M Calaf; M Prakash Hande; Tom K Hei
Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression.
International journal of oncology 2006;28(3):667-74.
2006: Boon Chin Heng; Kumar Jayaseelan Vinoth; Hua Liu; M Prakash Hande; tong cao
Low temperature tolerance of human embryonic stem cells.
International journal of medical sciences 2006;3(4):124-9.
2005: Anuradha Poonepalli; Lakshmidevi Balakrishnan; Aik Kia Khaw; Grace Kah Mun Low; Manikandan Jayapal; Rabindra N Bhattacharjee; Shizuo Akira; Adayabalam S Balajee; M Prakash Hande
Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite.
Cancer research 2005;65(23):10977-83.
2005: M Prakash Hande; Tamara V Azizova; Ludmilla E Burak; Valentin F Khokhryakov; Charles R Geard; David J Brenner
Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study.
Genes, chromosomes & cancer 2005;44(1):1-9.
2005: Ming Kei Lee; M Prakash Hande; Kanaga Sabapathy
Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis.
Journal of cell science 2005;118(Pt 4):819-29.
2005: Sabrina Giavara; Effie Kosmidou; M Prakash Hande; Marco E Bianchi; Alan Morgan; Fabrizio d'Adda di Fagagna; Stephen P Jackson
Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability.
Current biology : CB 2005;15(1):68-72.
2004: John Peter McPherson; Laura Tamblyn; Andrew Elia; Eva Migon; Amro Shehabeldin; Elzbieta Matysiak-Zablocki; Bénédicte Lemmers; Leonardo Salmena; Anne Hakem; Joel Fish; Farah Kassam; Jeremy Squire; Benoit G Bruneau; M Prakash Hande; Raza Hakem
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
The EMBO journal 2004;23(18):3677-88.
2004: Catherine R Mitchell; Tamara V Azizova; M Prakash Hande; Ludmilla E Burak; Josephine M Tsakok; Valentin F Khokhryakov; Charles R Geard; David J Brenner
Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals.
Radiation research 2004;162(3):257-63.
2004: Kevin M Hopkins; Wojtek Auerbach; Xiang Yuan Wang; M Prakash Hande; Haiying Hang; Debra J Wolgemuth; Alexandra L Joyner; Howard B Lieberman
Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality.
Molecular and cellular biology 2004;24(16):7235-48.
2004: John Peter McPherson; Bénédicte Lemmers; Richard Chahwan; Ashwin Pamidi; Eva Migon; Elzbieta Matysiak-Zablocki; Mary Ellen Moynahan; Jeroen Essers; Katsuhiro Hanada; Anuradha Poonepalli; Otto Sanchez-Sweatman; Rama Khokha; Roland Kanaar; Maria Jasin; M Prakash Hande; Raza Hakem
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
Science (New York, N.Y.) 2004;304(5678):1822-6.
2004: John Peter McPherson; Bénédicte Lemmers; Atsushi Hirao; Anne Hakem; Jacinth Abraham; Eva Migon; Elzbieta Matysiak-Zablocki; Laura Tamblyn; Otto Sanchez-Sweatman; Rama Khokha; Jeremy Squire; M Prakash Hande; Tak W Mak; Raza Hakem
Collaboration of Brca1 and Chk2 in tumorigenesis.
Genes & development 2004;18(10):1144-53.
2004: M Prakash Hande
DNA repair factors and telomere-chromosome integrity in mammalian cells.
Cytogenetic and genome research 2004;104(1-4):116-22.
2003: Jacinth Abraham; Bénédicte Lemmers; M Prakash Hande; Mary Ellen Moynahan; Charly Chahwan; Alberto Ciccia; Jeroen Essers; Katsuhiro Hanada; Richard Chahwan; Aik Kia Khaw; Peter McPherson; Amro Shehabeldin; Rob Laister; Cheryl H Arrowsmith; Roland Kanaar; Stephen C West; Maria Jasin; Raza Hakem
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells.
The EMBO journal 2003;22(22):6137-47.
2003: M Prakash Hande; Tamara V Azizova; Charles R Geard; Ludmilla E Burak; Catherine R Mitchell; Valentin F Khokhryakov; Evgeny K Vasilenko; David J Brenner
Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome.
American journal of human genetics 2003;72(5):1162-70.
2002: David J Brenner; SG Sawant; M Prakash Hande; RC Miller; Carl D Elliston; Z Fu; Gerhard Randers-Pehrson; Stephen A Marino
Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation?
International journal of radiation biology 2002;78(12):1065-7.
2002: Wei-Min Tong; Ulrich Cortes; M Prakash Hande; Hiroko Ohgaki; Luciane Cavalli; Peter M Lansdorp; Bassem R Haddad; Zhao-Qi Wang
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.
Cancer research 2002;62(23):6990-6.
2002: Alison M Y Cheung; M Prakash Hande; Farid Jalali; Ming Tsao; Brian F Skinnider; Atsushi Hirao; John Peter McPherson; Jana Karaskova; Akira Suzuki; Andrew Wakeham; Annick You-Ten; Andrew Elia; Jeremy Squire; Robert Bristow; Raza Hakem; Tak W Mak
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Cancer research 2002;62(21):6194-204.
2002: Paulo Peitl; Stephano S Mello; Marjori L Camparoto; Geraldo A S Passos; M Prakash Hande; Renato S Cardoso; Elza T Sakamoto-Hojo
Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene.
Mutagenesis 2002;17(1):67-72.
2001: David Gilley; H Tanaka; M Prakash Hande; Akihiro Kurimasa; Gloria C Li; M Oshimura; David J Chen
DNA-PKcs is critical for telomere capping.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15084-8.
2001: Wei-Min Tong; M Prakash Hande; Peter M Lansdorp; Zhao-Qi Wang
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Molecular and cellular biology 2001;21(12):4046-54.
2001: M Prakash Hande; Adayabalam S Balajee; A Tchirkov; A Wynshaw-Boris; Peter M Lansdorp
Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia.
Human molecular genetics 2001;10(5):519-28.
2001: Lauren D Wood; TL Halvorsen; Sonu Dhar; J A Baur; Raj K Pandita; W E Wright; M Prakash Hande; Gloria M Calaf; T K Hei; Fred Levine; J W Shay; J J Wang; Tej K Pandita
Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.
Oncogene 2001;20(3):278-88.
2001: David J Brenner; N Okladnikova; M Prakash Hande; Ludmilla E Burak; Charles R Geard; Tamara V Azizova
Biomarkers specific to densely-ionising (high LET) radiations.
Radiation protection dosimetry 2001;97(1):69-73.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; D Yeung; Natalie Erdmann; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.
Current biology : CB 2000;10(22):1459-62.
2000: Hsin Ling Hsu; David Gilley; Sanjeev Galande; M Prakash Hande; B Allen; Sung-Huo S H Kim; Gloria C Li; Judith Campisi; Terumi Kohwi-Shigematsu; David J Chen
Ku acts in a unique way at the mammalian telomere to prevent end joining.
Genes & development 2000;14(22):2807-12.
2000: Yie Liu; Bryan E Snow; M Prakash Hande; G Baerlocher; Valerie A Kickhoefer; D Yeung; Andrew Wakeham; Annick Itie; David Siderovski; PM Lansdorp; Murray O Robinson; Lea Harrington
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Molecular and cellular biology 2000;20(21):8178-84.
2000: S Dhar; J A Squire; M Prakash Hande; Raymund J Wellinger; Tej K Pandita
Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability.
Molecular and cellular biology 2000;20(20):7764-72.
1999: Stefan Lohwasser; M Prakash Hande; Dixie L Mager; Fumio Takei
Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells.
European journal of immunology 1999;29(3):755-61.
1999: M Prakash Hande; Predrag Slijepcevic; Andrew Silver; Simon D Bouffler; P van Buul; P Bryant; P Lansdorp
Elongated telomeres in scid mice.
Genomics 1999;56(2):221-3.
1999: M Prakash Hande; Enrique Samper; P Lansdorp; María A Blasco
Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice.
The Journal of cell biology 1999;144(4):589-601.
1998: K Fukuda; Hiromu Nakajima; E Taniguchi; K Sutoh; H Wang; M Prakash Hande; LY Li; Masayuki Kurooka; K Mori; Tadashi Hongyo; Takeshi Kubo; Taisei Nomura
Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice.
Cancer letters 1998;132(1-2):153-8.
1998: M Prakash Hande; Adayapalam T Natarajan
Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. IV. Dose response.
International journal of radiation biology 1998;74(4):441-8.
1998: M Prakash Hande; P M Lansdorp; Adayapalam T Natarajan
Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing.
Mutation research 1998;404(1-2):205-14.
1998: L Zhu; Karen S Hathcock; M Prakash Hande; P M Lansdorp; Michael F Seldin; Richard J Hodes
Telomere length regulation in mice is linked to a novel chromosome locus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8648-53.
1997: Predrag Slijepcevic; M Prakash Hande; Simon D Bouffler; P Lansdorp; Peter E Bryant
Telomere length, chromatin structure and chromosome fusigenic potential.
Chromosoma 1997;106(7):413-21.
1997: M A Blasco; H W Lee; M Prakash Hande; E Samper; P M Lansdorp; Ronald A DePinho; Carol W Greider
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
Cell 1997;91(1):25-34.
1997: M Prakash Hande; Adayabalam S Balajee; A T Natarajan
Induction of telomerase activity by UV-irradiation in Chinese hamster cells.
Oncogene 1997;15(14):1747-52.
1997: Taisei Nomura; Hiromu Nakajima; Tadashi Hongyo; E Taniguchi; K Fukuda; LY Li; Masayuki Kurooka; K Sutoh; M Prakash Hande; T Kawaguchi; M Ueda; Hiroshi Takatera
Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice.
Cancer research 1997;57(11):2081-4.
1997: M Prakash Hande; J J W A Boei; Adayapalam T Natarajan
Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. III. Chromosome malsegregation/aneuploidy.
Mutagenesis 1997;12(3):125-31.
1997: S Sebastian; B Hoebee; M Prakash Hande; UW Kenkare; Adayapalam T Natarajan
Assignment of hexokinase types 1,2,3 (Hk1,2,3) and glucokinase (Gck) to rat chromosome band 20q11, 4q34, 17q12 and 14q21 respectively, by in situ hybridization.
Cytogenetics and cell genetics 1997;77(3-4):266-7.
1997: T Kawaguchi; Hiromu Nakajima; Tadashi Hongyo; K Fukuda; E Taniguchi; K Sutoh; H Wang; M Prakash Hande; LY Li; Masayuki Kurooka; T Iwasa; Nobuo Kurokawa; Riichiro Nezu; M Miyata; H Matsuda; Taisei Nomura
Consecutive maintenance of human solitary and hereditary colorectal polyps in SCID mice.
Cancer detection and prevention 1997;21(2):148-57.
1996: Adayapalam T Natarajan; Adayabalam S Balajee; J J W A Boei; Firouz Darroudi; I Dominguez; M Prakash Hande; M Meijers; Predrag Slijepcevic; S Vermeulen; Y Xiao
Mechanisms of induction of chromosomal aberrations and their detection by fluorescence in situ hybridization.
Mutation research 1996;372(2):247-58.
1996: M Prakash Hande; J J W A Boei; Adayapalam T Natarajan
Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. II. Micronuclei.
International journal of radiation biology 1996;70(4):375-83.
1996: Adayapalam T Natarajan; J J W A Boei; Firouz Darroudi; P C Van Diemen; Fernando Noel Dulout; M Prakash Hande; A T Ramalho
Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens.
Environmental health perspectives 1996;104 Suppl 3():445-8.
1996: M Prakash Hande; J J W A Boei; Fredrik Granath; Adayapalam T Natarajan
Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations.
International journal of radiation biology 1996;69(4):437-46.
1995: A N Jha; M Prakash Hande; Leon H F Mullenders; Adayapalam T Natarajan
Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary or transformed human lymphocytes.
Mutagenesis 1995;10(5):385-91.
1995: P Uma Devi; R Suresh; M Prakash Hande
Effect of fetal exposure to ultrasound on the behavior of the adult mouse.
Radiation research 1995;141(3):314-7.
1995: M Prakash Hande; P Uma Devi
Teratogenic effects of repeated exposures to X-rays and/or ultrasound in mice.
Neurotoxicology and teratology 1995;17(2):179-88.
1994: P Uma Devi; R Baskar; M Prakash Hande
Effect of exposure to low-dose gamma radiation during late organogenesis in the mouse fetus.
Radiation research 1994;138(1):133-8.
1993: M Prakash Hande; P Uma Devi
Effect of in utero exposure to diagnostic ultrasound on the postnatal survival and growth of mouse.
Teratology 1993;48(5):405-11.
1993: M Prakash Hande; P Uma Devi; K S Karanth
Effect of prenatal ultrasound exposure on adult behavior in mice.
Neurotoxicology and teratology 1993;15(6):433-8.
1993: M Prakash Hande; K Veena
Teratogenic effect of hyperthermia during early organogenesis period in mice.
Teratogenesis, carcinogenesis, and mutagenesis 1993;13(3):145-50.
1992: M Prakash Hande; P Uma Devi
Effect of prenatal exposure to diagnostic ultrasound on the development of mice.
Radiation research 1992;130(1):125-8.
1990: M Prakash Hande; P Ume Devi; Ganesh Chandra Jagetia
Effect of "in utero" exposure to low doses of low energy X-rays on the postnatal development of mouse.
Journal of radiation research 1990;31(4):354-60.
1990: P Uma Devi; M Prakash Hande
Effect of low dose of 70 kVp X-rays on the intrauterine development of mice.
Experientia 1990;46(5):511-3.