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Daniel Lawrence

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Chemicals & Drugs

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Maithili Sashindranath; Enming Joseph Su; Jean-Dominique Vassalli; Cristina Morganti-Kossmann; Jeffrey V Rosenfeld; Eunice Sales; Andre L Samson; Simone Beckham; Elisa J Cops; Maria Daglas; Roxann Freeman; Adam Galle; Daniel Lawrence; Rime MADANI; Catriona McLean; Robert L Medcalf
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans.
Ryan A Frieler; Daniel Lawrence; He Meng; David J Pinsky; Sai P Ramnarayanan; Jessica J Ray; Enming Joseph Su; Michael G Usher; Michael M Wang; Stefan Berger; richard mortensen
Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.
John Osterholzer; Richard H Simon; Natalya M Subbotina; Paul J Christensen; Andrew Cunningham; Noboru Hattori; Jeffrey C Horowitz; Vibha N Lama; Daniel Lawrence; Yujing Lin; Roger E Morey; Benjamin J Murdock; Michal Olszewski; Thomas H Sisson
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

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All Publications

2012: Maithili Sashindranath; Enming Joseph Su; Jean-Dominique Vassalli; Cristina Morganti-Kossmann; Jeffrey V Rosenfeld; Eunice Sales; Andre L Samson; Simone Beckham; Elisa J Cops; Maria Daglas; Roxann Freeman; Adam Galle; Daniel Lawrence; Rime MADANI; Catriona McLean; Robert L Medcalf
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans.
Brain : a journal of neurology 2012;135(Pt 11):3251-64.
2012: Ryan A Frieler; Daniel Lawrence; He Meng; David J Pinsky; Sai P Ramnarayanan; Jessica J Ray; Enming Joseph Su; Michael G Usher; Michael M Wang; Stefan Berger; richard mortensen
Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.
Journal of the American Heart Association 2012;1(5):e002584.
2012: John Osterholzer; Richard H Simon; Natalya M Subbotina; Paul J Christensen; Andrew Cunningham; Noboru Hattori; Jeffrey C Horowitz; Vibha N Lama; Daniel Lawrence; Yujing Lin; Roger E Morey; Benjamin J Murdock; Michal Olszewski; Thomas H Sisson
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.
The Journal of pathology 2012;228(2):170-80.
2012: Enming Joseph Su; Daniel Lawrence
The functional dissonance of platelets.
Blood 2012;120(6):1154-5.
2012: Daniel Lawrence; Ann Arbor; Enming Joseph Su; Karl-Uwe Petersen
Thrombomodulin and the brain: past, present, and future.
Neurology 2012;78(16):1280-1.
2012: Linda Fredriksson; Ingrid Nilsson; Enming Joseph Su; Johanna Andrae; Christer Betsholtz; Hao Ding; Ulf Eriksson; Daniel Lawrence
Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.
The American journal of pathology 2012;180(3):1136-44.
2012: Jose Antonio Diaz; Diana M Farris; Angela E Hawley; Peter K Henke; Daniel Lawrence; Daniel Durant Myers Jr; Nicole E Ballard-Lipka; Shirley K Wrobleski; Thomas W Wakefield
Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis.
Journal of vascular surgery 2012;55(3):815-22.
2012: Lingyan Wang; Chun-Ying Ko; Daniel Lawrence; Christine M Ly; Erin E Meyers; Audrey M Bernstein
uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin.
Investigative ophthalmology & visual science 2012;53(8):4765-75.
2012: Amandine Cartier-Michaud; Cécile Charrière-Bertrand; Franck Delaplace; Gilles Gadea; Guillaume Hutzler; Daniel Lawrence; Annick Lesne; Michel Malo; Pierre Roux; Ajitha Supiramaniam; Christelle Anguille; Georgia Barlovatz-Meimon
Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling.
PloS one 2012;7(2):e32204.
2011: Anthony J Courey; Andrew K Cunningham; Monica P Goldklang; Jeffrey C Horowitz; Kevin K Kim; Timothy J Koh; Daniel Lawrence; Yujing Lin; Margaret L Novak; Richard H Simon; Natalya M Subbotina; Mark Warnock; Bing Xue; Thomas H Sisson
The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.
Blood 2011;118(8):2313-21.
2011: Yan Ji; Daniel Lawrence; Alexander W Lohman; Meredith J Stevenson; Tammy L Strawn; Elizabeth A Grunz; William P Fay
Multifaceted role of plasminogen activator inhibitor-1 in regulating early remodeling of vein bypass grafts.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(8):1781-7.
2011: Enming Joseph Su; M Wahl; K Mann; K U Petersen; H Brohmann; M Geyer; David Ginsburg; Daniel Lawrence
The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model.
Journal of thrombosis and haemostasis : JTH 2011;9(6):1174-82.
2011: Aleksandra E Sikora; Ryszard A Zielke; Daniel Lawrence; Philip C Andrews; maria sandkvist
Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases.
The Journal of biological chemistry 2011;286(19):16555-66.
2011: Shih-Hon Li; Daniel Lawrence
Development of inhibitors of plasminogen activator inhibitor-1.
Methods in enzymology 2011;501():177-207.
2011: Nan Zhang; Daniel Lawrence
Tissue factor and obesity, a two-way street.
Nature medicine 2011;17(11):1343-4.
2010: Shih-Hon Li; Daniel Lawrence
Sometimes a cigar is just a cigar.
Blood 2010;116(9):1394-5.
2010: N Garg; N Goyal; T L Strawn; J Wu; K M Mann; Daniel Lawrence; William P Fay
Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices.
Journal of thrombosis and haemostasis : JTH 2010;8(8):1847-54.
2010: He Meng; Xiaojie Zhang; Soo Jung Lee; Dudley K Strickland; Daniel Lawrence; Michael M Wang
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
The Journal of biological chemistry 2010;285(30):23047-55.
2010: Jacqueline M Cale; Shih-Hon Li; Mark Warnock; Enming Joseph Su; Paul R North; Karen L Sanders; Maria M Puscau; Cory D Emal; Daniel Lawrence
Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1.
The Journal of biological chemistry 2010;285(11):7892-902.
2010: Nadine C El-Ayache; Shih-Hon Li; Mark Warnock; Daniel Lawrence; Cory D Emal
Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1).
Bioorganic & medicinal chemistry letters 2010;20(3):966-70.
2009: Yufeng Huang; Wayne A Border; Daniel Lawrence; Nancy A Noble
Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis.
American journal of physiology. Renal physiology 2009;297(4):F1045-54.
2009: Jianbo Wu; Lin Peng; Grainne A McMahon; Daniel Lawrence; William P Fay
Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1565-70.
2009: Dianer Yang; Niza Nemkul; Ahmed Shereen; Alice Jone; R Scott Dunn; Daniel Lawrence; Diana Lindquist; Chia-Yi Kuan
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(27):8669-74.
2009: Brenda Waning; Warren Kaplan; Alexis C King; Daniel Lawrence; Hubert G Leufkens; Matthew P Fox
Global strategies to reduce the price of antiretroviral medicines: evidence from transactional databases.
Bulletin of the World Health Organization 2009;87(7):520-8.
2009: Enming Joseph Su; L Fredriksson; Gerald P Schielke; U Eriksson; Daniel Lawrence
Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():155-8.
2009: Charlene M Blake; Bruce A Sullenger; Daniel Lawrence; YOLANDA FORTENBERRY
Antimetastatic potential of PAI-1-specific RNA aptamers.
Oligonucleotides 2009;19(2):117-28.
2009: Matthew C Hyman; Danica Petrovic-Djergovic; Scott H Visovatti; Hui Liao; Sunitha Yanamadala; Diane Bouïs; Enming Joseph Su; Daniel Lawrence; M Johan Broekman; Aaron J Marcus; David J Pinsky
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.
The Journal of clinical investigation 2009;119(5):1136-49.
2008: Andre L Samson; Simon T Nevin; David Croucher; Be'eri Niego; Philip Daniel; Thomas Weiss; Eliza Moreno; Denis Monard; Daniel Lawrence; Robert L Medcalf
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.
Journal of neurochemistry 2008;107(4):1091-101.
2008: Enming Joseph Su; Linda Fredriksson; Melissa Geyer; Erika Folestad; Jacqueline Cale; Johanna Andrae; Yamei Gao; Kristian Pietras; Kris Mann; Manuel Yepes; Dudley K Strickland; Christer Betsholtz; Ulf Eriksson; Daniel Lawrence
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.
Nature medicine 2008;14(7):731-7.
2008: Shih-Hon Li; Natalia V Gorlatova; Daniel Lawrence; Bradford S. Schwartz
Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands.
The Journal of biological chemistry 2008;283(26):18147-57.
2008: Miina Ohman; Yuechun Shen; Chinyere I Obimba; Andrew P Wright; Mark Warnock; Daniel Lawrence; Daniel T Eitzman
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice.
Circulation 2008;117(6):798-805.
2008: Yufeng Huang; Wayne A Border; Ling Yu; jiandong Zhang; Daniel Lawrence; Nancy A Noble
A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2008;19(2):329-38.
2008: Elizabeth Fabre-Guillevin; Michel Malo; Amandine Cartier-Michaud; Hector Peinado; Gema Moreno-Bueno; Benoît Vallée; Daniel Lawrence; José Palacios; Amparo Cano; Georgia Barlovatz-Meimon; Cécile Charrière-Bertrand
PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.
Breast cancer research : BCR 2008;10(6):R100.
2007: Jacqueline M Cale; Daniel Lawrence
Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent.
Current drug targets 2007;8(9):971-81.
2007: Steingrimur Stefansson; Enming Joseph Su; Shoji Ishigami; Jacqueline M Cale; Yamei Gao; Natalia V Gorlatova; Daniel Lawrence
The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin.
The Journal of biological chemistry 2007;282(21):15679-89.
2007: Rohini Polavarapu; Maria Carolina Gongora; Hong Yi; Sripriya Ranganthan; Daniel Lawrence; Dudley K Strickland; Manuel Yepes
Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.
Blood 2007;109(8):3270-8.
2007: Natalia V Gorlatova; Jacqueline M Cale; Hassan Elokdah; Donghua Li; Kristi Fan; Mark Warnock; David L Crandall; Daniel Lawrence
Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.
The Journal of biological chemistry 2007;282(12):9288-96.
2007: Hui Liao; Matthew C Hyman; Daniel Lawrence; David J Pinsky
Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(3):935-49.
2007: Shoji Ishigami; maria sandkvist; Foon Tsui; Elizabeth Moore; Timothy A Coleman; Daniel Lawrence
Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.
The Biochemical journal 2007;402(1):25-34.
2007: John W Cole; Adam C Naj; Jeffrey R O'Connell; O Colin Stine; John D Sorkin; Marcella A Wozniak; Barney J Stern; Manuel Yepes; Daniel Lawrence; Laurie J Reinhart; Dudley K Strickland; Braxton D Mitchell; Steven Kittner
Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study.
BMC neurology 2007;7():37.
2006: Courtney E Leik; Enming Joseph Su; Ponnal Nambi; David L Crandall; Daniel Lawrence
Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2710-5.
2006: François Maquerlot; Stéphane Galiacy; Michel Malo; Christophe Guignabert; Daniel Lawrence; Marie-Pia d'Ortho; Georgia Barlovatz-Meimon
Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing.
The American journal of pathology 2006;169(5):1624-32.
2006: Yufeng Huang; Wayne A Border; Daniel Lawrence; Nancy A Noble
Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis.
Kidney international 2006;70(3):515-22.
2006: Chunzhang Cao; Daniel Lawrence; Yang Li; Christine A F Von Arnim; Joachim Herz; Enming Joseph Su; Alexandra Makarova; Bradley T Hyman; Dudley K Strickland; Li Zhang
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.
The EMBO journal 2006;25(9):1860-70.
2005: Chunzhang Cao; Daniel Lawrence; Dudley K Strickland; Li Zhang
A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics.
Blood 2005;106(9):3234-41.
2005: Kenneth H Minor; Christine R Schar; GRant Blouse; Joseph D Shore; Daniel Lawrence; Peter Schuck; Cynthia B Peterson
A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis.
The Journal of biological chemistry 2005;280(31):28711-20.
2005: Jose Ruiz; Diana Kouiavskaia; Molly Migliorini; Susan Robinson; Evgueni L Saenko; Natalia V Gorlatova; Donghua Li; Daniel Lawrence; Bradley T Hyman; Karl H Weisgraber; Dudley K Strickland
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.
Journal of lipid research 2005;46(8):1721-31.
2005: Toni M Antalis; Thomas H Bugge; Daniel Lawrence; Sarah Netzel-Arnett; Bradford S. Schwartz; Dudley K Strickland
Amalfi to Washington D. C.--twenty years of plasminogen activator research.
Thrombosis and haemostasis 2005;93(4):625-6.
2005: Manuel Yepes; Sharron A N Brown; Elizabeth G Moore; Elizabeth P Smith; Daniel Lawrence; Jeffrey A Winkles
A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia.
The American journal of pathology 2005;166(2):511-20.
2004: Manuel Yepes; Daniel Lawrence
New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system.
Experimental biology and medicine (Maywood, N.J.) 2004;229(11):1097-104.
2004: John P Hobson; Sarah Netzel-Arnett; Roman Szabo; Sophie M Réhault; Frank Church; Dudley K Strickland; Daniel Lawrence; Toni M Antalis; Thomas H Bugge
Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes.
The Journal of biological chemistry 2004;279(45):46981-94.
2004: David L Crandall; Hassan Elokdah; L Di; James K Hennan; Natalia V Gorlatova; Daniel Lawrence
Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy.
Journal of thrombosis and haemostasis : JTH 2004;2(8):1422-8.
2004: Tambet Teesalu; Andres Kulla; Aadu Simisker; Vappu Sirén; Daniel Lawrence; Toomas Asser; Antti Vaheri
Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system.
Thrombosis and haemostasis 2004;92(2):358-68.
2004: Steingrimur Stefansson; Manuel Yepes; Natalia V Gorlatova; Duane E Day; Elizabeth G Moore; Adriana Zabaleta; Grainne A McMahon; Daniel Lawrence
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
The Journal of biological chemistry 2004;279(29):29981-7.
2004: Manuel Yepes; Daniel Lawrence
Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system?
Trends in cardiovascular medicine 2004;14(5):173-80.
2004: Zhi Xu; Rashna D Balsara; Natalia V Gorlatova; Daniel Lawrence; Francis J Castellino; Victoria A Ploplis
Conservation of critical functional domains in murine plasminogen activator inhibitor-1.
The Journal of biological chemistry 2004;279(17):17914-20.
2004: Manuel Yepes; Daniel Lawrence
Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system.
Thrombosis and haemostasis 2004;91(3):457-64.
2004: Toni M Antalis; Daniel Lawrence
Serpin mutagenesis.
Methods (San Diego, Calif.) 2004;32(2):130-40.
2003: Alexandra Makarova; Irina Mikhailenko; Thomas H Bugge; Karin List; Daniel Lawrence; Dudley K Strickland
The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes.
The Journal of biological chemistry 2003;278(50):50250-8.
2003: Manuel Yepes; maria sandkvist; Elizabeth G Moore; Thomas H Bugge; Dudley K Strickland; Daniel Lawrence
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.
The Journal of clinical investigation 2003;112(10):1533-40.
2003: Yang Li; Daniel Lawrence; Li Zhang
Sequences within domain II of the urokinase receptor critical for differential ligand recognition.
The Journal of biological chemistry 2003;278(32):29925-32.
2003: Yufeng Huang; Masashi Haraguchi; Daniel Lawrence; Wayne A Border; Ling Yu; Nancy A Noble
A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis.
The Journal of clinical investigation 2003;112(3):379-88.
2003: Manuel Yepes; Elizabeth Moore; Sharron A N Brown; Heather N Hanscom; Elizabeth P Smith; Daniel Lawrence; Jeffrey A Winkles
Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures.
Laboratory investigation; a journal of technical methods and pathology 2003;83(7):1025-32.
2003: Steingrimur Stefansson; Daniel Lawrence
Old dogs and new tricks: proteases, inhibitors, and cell migration.
Science's STKE : signal transduction knowledge environment 2003;2003(189):pe24.
2003: Djordje Gveric; blanca herrera; Axel Petzold; Daniel Lawrence; M Louise Cuzner
Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors.
Brain : a journal of neurology 2003;126(Pt 7):1590-8.
2003: Natalia V Gorlatova; Hassan Elokdah; Kristi Fan; David L Crandall; Daniel Lawrence
Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function.
The Journal of biological chemistry 2003;278(18):16329-35.
2003: Steingrimur Stefansson; Grainne A McMahon; Eric Petitclerc; Daniel Lawrence
Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling.
Current pharmaceutical design 2003;9(19):1545-64.
2002: Alejandro Curino; David J Mitola; Hannah Aaronson; Grainne A McMahon; Kamran Raja; Achsah D Keegan; Daniel Lawrence; Thomas H Bugge
Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages.
Oncogene 2002;21(57):8830-42.
2002: Karen Barker-Carlson; Daniel Lawrence; Bradford S. Schwartz
Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.
The Journal of biological chemistry 2002;277(49):46852-7.
2002: Zheng Gang Zhang; Li Zhang; Manuel Yepes; Quan Jiang; Qingjiang Li; Polly Arniego; Timothy A Coleman; Daniel Lawrence; Michael Chopp
Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke.
Circulation 2002;106(6):740-5.
2002: Richard L Davis; Antony E Shrimpton; Robin W Carrell; David A Lomas; Lieselotte Gerhard; Bruno Baumann; Daniel Lawrence; Manuel Yepes; Tai Seung Kim; Bernardino Ghetti; Pedro Piccardo; Masaki Takao; Felicitas Lacbawan; Maximilian Muenke; Richard N Sifers; Charles B Bradshaw; Paul F Kent; George H Collins; Daria Larocca; Peter D Holohan
Association between conformational mutations in neuroserpin and onset and severity of dementia.
Lancet 2002;359(9325):2242-7.
2002: Manuel Yepes; maria sandkvist; Timothy A Coleman; Elizabeth Moore; Jiang-Young Wu; David J Mitola; Thomas H Bugge; Daniel Lawrence
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
The Journal of clinical investigation 2002;109(12):1571-8.
2002: Elena Loukinova; Sripriya Ranganathan; Sergey Kuznetsov; Natalia V Gorlatova; Molly Migliorini; Dmitri Loukinov; Paula G Ulery; Irina Mikhailenko; Daniel Lawrence; Dudley K Strickland
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.
The Journal of biological chemistry 2002;277(18):15499-506.
2002: Marija Backovic; efstratios stratikos; Daniel Lawrence; Peter G W Gettins
Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment.
Protein science : a publication of the Protein Society 2002;11(5):1182-91.
2001: Grainne A McMahon; Eric Petitclerc; Steingrimur Stefansson; E Smith; M K Wong; Randal J Westrick; David Ginsburg; Peter C Brooks; Daniel Lawrence
Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.
The Journal of biological chemistry 2001;276(36):33964-8.
2001: P Reisdorf; Daniel Lawrence; Virginie Sivan; E Klising; M T Martin
Alteration of transforming growth factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis.
The American journal of pathology 2001;159(1):263-72.
2001: Steingrimur Stefansson; Eric Petitclerc; M K Wong; Grainne A McMahon; Peter C Brooks; Daniel Lawrence
Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1.
The Journal of biological chemistry 2001;276(11):8135-41.
2001: Eileen M Redmond; John Cullen; Paul A Cahill; James V Sitzmann; S Stefansson; Daniel Lawrence; S S Okada
Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1.
Circulation 2001;103(4):597-603.
2000: Masaki Takao; Merrill D Benson; Jill R Murrell; Masahide Yazaki; Pedro Piccardo; Frederick W Unverzagt; Richard L Davis; Peter D Holohan; Daniel Lawrence; R Richardson; Martin R Farlow; Bernardino Ghetti
Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy.
Journal of neuropathology and experimental neurology 2000;59(12):1070-86.
2000: Manuel Yepes; maria sandkvist; M K Wong; Timothy A Coleman; E Smith; S L Cohan; Daniel Lawrence
Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis.
Blood 2000;96(2):569-76.
2000: Thomas J Podor; Cynthia B Peterson; Daniel Lawrence; S Stefansson; Stephen G Shaughnessy; Denise M Foulon; Martin Butcher; Jeffrey I Weitz
Type 1 plasminogen activator inhibitor binds to fibrin via vitronectin.
The Journal of biological chemistry 2000;275(26):19788-94.
2000: Daniel Lawrence; Steven T Olson; S Muhammad; Duane E Day; Jan-Olov Kvassman; David Ginsburg; Joseph D Shore
Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.
The Journal of biological chemistry 2000;275(8):5839-44.
1999: Richard L Davis; Peter D Holohan; Antony E Shrimpton; Arthur H Tatum; JW Daucher; George H Collins; R Todd; C Bradshaw; Paul F Kent; D Feiglin; A Rosenbaum; M S Yerby; C M Shaw; Felicitas Lacbawan; Daniel Lawrence
Familial encephalopathy with neuroserpin inclusion bodies.
The American journal of pathology 1999;155(6):1901-13.
1999: Richard L Davis; Antony E Shrimpton; Peter D Holohan; C Bradshaw; D Feiglin; George H Collins; Peter Sonderegger; Jochen Kinter; L M Becker; Felicitas Lacbawan; D Krasnewich; Maximilian Muenke; Daniel Lawrence; M S Yerby; C M Shaw; Bibek Gooptu; PR Elliott; J T Finch; Robin W Carrell; David A Lomas
Familial dementia caused by polymerization of mutant neuroserpin.
Nature 1999;401(6751):376-9.
1999: A M Sharp; Penelope E Stein; Neesh Pannu; Robin W Carrell; M B Berkenpas; David Ginsburg; Daniel Lawrence; Randy J Read
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.
Structure (London, England : 1993) 1999;7(2):111-8.
1998: S Stefansson; Christian C Haudenschild; Daniel Lawrence
Beyond fibrinolysis: the role of plasminogen activator inhibitor-1 and vitronectin in vascular wound healing.
Trends in cardiovascular medicine 1998;8(4):175-80.
1998: S Stefansson; S Muhammad; X F Cheng; Frances D Battey; Dudley K Strickland; Daniel Lawrence
Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1998;273(11):6358-66.
1998: S Stefansson; Daniel Lawrence; Thomas Herren; Edward F Plow
Novel approaches to thrombolysis based on modulation of endogenous fibrinolysis.
Coronary artery disease 1998;9(2-3):99-104.
1997: Gregg Hastings; Timothy A Coleman; Christian Haudenschild; S Stefansson; EP Smith; R Barthlow; S Cherry; maria sandkvist; Daniel Lawrence
Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival.
The Journal of biological chemistry 1997;272(52):33062-7.
1997: JA Huntington; B Fan; K E Karlsson; J Deinum; Daniel Lawrence; Peter G W Gettins
Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations.
Biochemistry 1997;36(18):5432-40.
1997: Daniel Lawrence
The serpin-proteinase complex revealed.
Nature structural biology 1997;4(5):339-41.
1997: Daniel Lawrence; S Palaniappan; Steingrimur Stefansson; Steven T Olson; A M Francis-Chmura; Joseph D Shore; David Ginsburg
Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis.
The Journal of biological chemistry 1997;272(12):7676-80.
1997: Daniel Lawrence
The role of reactive-center loop mobility in the serpin inhibitory mechanism.
Advances in experimental medicine and biology 1997;425():99-108.
1996: S Stefansson; Daniel Lawrence
The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin.
Nature 1996;383(6599):441-3.
1996: S Stefansson; Daniel Lawrence; Scott Argraves
Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.
The Journal of biological chemistry 1996;271(14):8215-20.
1995: Steven T Olson; Paul E Bock; Jan-Olov Kvassman; Joseph D Shore; Daniel Lawrence; David Ginsburg; Ingemar Björk
Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.
The Journal of biological chemistry 1995;270(50):30007-17.
1995: Jan-Olov Kvassman; Daniel Lawrence; Joseph D Shore
The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.
The Journal of biological chemistry 1995;270(46):27942-7.
1995: Daniel Lawrence; David Ginsburg; D E Day; M B Berkenpas; Ingrid Verhamme; Jan-Olov Kvassman; Joseph D Shore
Serpin-protease complexes are trapped as stable acyl-enzyme intermediates.
The Journal of biological chemistry 1995;270(43):25309-12.
1995: Z Yang; R L Cohen; G M Lui; Daniel Lawrence; Marc Shuman
Thrombin increases expression of urokinase receptor by activation of the thrombin receptor.
Investigative ophthalmology & visual science 1995;36(11):2254-61.
1995: M B Berkenpas; Daniel Lawrence; David Ginsburg
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
The EMBO journal 1995;14(13):2969-77.
1995: Daniel T Eitzman; William P Fay; Daniel Lawrence; A M Francis-Chmura; Joseph D Shore; Steven T Olson; David Ginsburg
Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro.
The Journal of clinical investigation 1995;95(5):2416-20.
1995: P M Sherman; Daniel Lawrence; Ingrid Verhamme; D Paielli; Joseph D Shore; David Ginsburg
Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity.
The Journal of biological chemistry 1995;270(16):9301-6.
1995: Joseph D Shore; D E Day; A M Francis-Chmura; Ingrid Verhamme; Jan-Olov Kvassman; Daniel Lawrence; David Ginsburg
A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism.
The Journal of biological chemistry 1995;270(10):5395-8.
1994: Daniel Lawrence; Steven T Olson; S Palaniappan; David Ginsburg
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
The Journal of biological chemistry 1994;269(44):27657-62.
1994: Anders Nykjaer; Lars Kjøller; R L Cohen; Daniel Lawrence; B A Garni-Wagner; Robert F Todd III; A J van Zonneveld; Jørgen Gliemann; Peter A Andreasen
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.
The Journal of biological chemistry 1994;269(41):25668-76.
1994: Anders Nykjaer; Lars Kjøller; R L Cohen; Daniel Lawrence; Jørgen Gliemann; Peter A Andreasen
Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor.
Annals of the New York Academy of Sciences 1994;737():483-5.
1994: Daniel Lawrence; M B Berkenpas; S Palaniappan; David Ginsburg
Localization of vitronectin binding domain in plasminogen activator inhibitor-1.
The Journal of biological chemistry 1994;269(21):15223-8.
1994: I F Mizukami; B A Garni-Wagner; L M DeAngelo; Monica Liebert; Andrew Flint; Daniel Lawrence; R L Cohen; Robert F Todd III
Immunologic detection of the cellular receptor for urokinase plasminogen activator.
Clinical immunology and immunopathology 1994;71(1):96-104.
1994: Daniel Lawrence; Steven T Olson; S Palaniappan; David Ginsburg
Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.
Biochemistry 1994;33(12):3643-8.
1994: E Bianchi; R L Cohen; A T Thor; Robert F Todd III; I F Mizukami; Daniel Lawrence; Britt-Marie Ljung; Marc Shuman; HS Smith
The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue.
Cancer research 1994;54(4):861-6.
1993: Michael Naski; Daniel Lawrence; D F Mosher; T J Podor; David Ginsburg
Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin.
The Journal of biological chemistry 1993;268(17):12367-72.
1992: P M Sherman; Daniel Lawrence; A Y Yang; E T Vandenberg; D Paielli; Steven T Olson; Joseph D Shore; David Ginsburg
Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
The Journal of biological chemistry 1992;267(11):7588-95.
1991: L Strandberg; Daniel Lawrence; Lennart B-A Johansson; T Ny
The oxidative inactivation of plasminogen activator inhibitor type 1 results from a conformational change in the molecule and does not require the involvement of the P1' methionine.
The Journal of biological chemistry 1991;266(21):13852-8.
1990: Daniel Lawrence; L Strandberg; J Ericson; T Ny
Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants.
The Journal of biological chemistry 1990;265(33):20293-301.
1989: Daniel Lawrence; L Strandberg; Thomas Grundström; T Ny
Purification of active human plasminogen activator inhibitor 1 from Escherichia coli. Comparison with natural and recombinant forms purified from eucaryotic cells.
European journal of biochemistry / FEBS 1989;186(3):523-33.
1988: L Strandberg; Daniel Lawrence; T Ny
The organization of the human-plasminogen-activator-inhibitor-1 gene. Implications on the evolution of the serine-protease inhibitor family.
European journal of biochemistry / FEBS 1988;176(3):609-16.
1986: Daniel Lawrence; D J Loskutoff
Inactivation of plasminogen activator inhibitor by oxidants.
Biochemistry 1986;25(21):6351-5.
1986: T Ny; M Sawdey; Daniel Lawrence; J L Millan; D J Loskutoff
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6776-80.
1986: D J Loskutoff; T Ny; M Sawdey; Daniel Lawrence
Fibrinolytic system of cultured endothelial cells: regulation by plasminogen activator inhibitor.
Journal of cellular biochemistry 1986;32(4):273-80.
1985: Y Sakata; S Curriden; Daniel Lawrence; J H Griffin; D J Loskutoff
Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(4):1121-5.
1984: J A van Mourik; Daniel Lawrence; D J Loskutoff
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.
The Journal of biological chemistry 1984;259(23):14914-21.
1984: L Mussoni; Daniel Lawrence; D J Loskutoff
A direct, plasmin-independent assay for plasminogen activator.
Thrombosis research 1984;34(3):241-54.
1984: L A Erickson; Daniel Lawrence; D J Loskutoff
Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis.
Analytical biochemistry 1984;137(2):454-63.
1983: D J Loskutoff; J A van Mourik; L A Erickson; Daniel Lawrence
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(10):2956-60.