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Dennis Bruemmer

Research Profile

Anatomy

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Publications

TOP 3
Hannes M Findeisen; Florian K Kahles; Dennis Bruemmer
Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.
Hannes M Findeisen; Florian K Kahles; Dennis Bruemmer
Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.
Hannes Findeisen; Dennis Bruemmer
Response to "Lack of evidence to support a beneficial role for glutathione depletion on body weight or glucose intolerance".

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All Publications

2013: Hannes M Findeisen; Florian K Kahles; Dennis Bruemmer
Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.
Current atherosclerosis reports 2013;15(5):319.
2013: Hannes M Findeisen; Florian K Kahles; Dennis Bruemmer
Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis.
Current atherosclerosis reports 2013;15(4):319.
2013: Hannes Findeisen; Dennis Bruemmer
Response to "Lack of evidence to support a beneficial role for glutathione depletion on body weight or glucose intolerance".
Obesity (Silver Spring, Md.) 2013;21(1):3-4.
2012: Hong Lu; Debra L Rateri; Dennis Bruemmer; Lisa A Cassis; Alan Daugherty
Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.
Clinical science (London, England : 1979) 2012;123(9):531-43.
2012: Hong Lu; Debra L Rateri; Dennis Bruemmer; Lisa A Cassis; Alan Daugherty
Novel mechanisms of abdominal aortic aneurysms.
Current atherosclerosis reports 2012;14(5):402-12.
2012: Xuan Zhang; Dennis Bruemmer; Richard Charnigo; Alan Daugherty; Debra L Rateri; Sean E Thatcher; Lisa A Cassis
Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.
Circulation research 2012;110(11):e73-85.
2012: Dennis Bruemmer
Targeting angiogenesis as treatment for obesity.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):161-2.
2012: Venkateswaran Subramanian; Dennis Bruemmer; Jonathan Golledge; Elizabeth B Heywood; Alan Daugherty
Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):397-405.
2011: Hannes Findeisen; Florence Gizard; Elizabeth B Heywood; Karrie L Jones; Hua Qing; Yue Zhao; Dianne Cohn; Dennis Bruemmer
Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity.
Obesity (Silver Spring, Md.) 2011;19(12):2429-32.
2011: Florence Gizard; Elizabeth B Heywood; Karrie L Jones; Takashi Nomiyama; Hua Qing; Yue Zhao; Dianne Cohn; Hannes Findeisen; Dennis Bruemmer
Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells.
The Journal of biological chemistry 2011;286(41):35485-93.
2011: Katharina G Kehl; David M Mannino; Dennis Bruemmer; David Fardo; Hannes Findeisen; Wayne T Sanderson
Race-ethnicity as an effect modifier of the association between HbAlc and mortality in U.S. adults without diagnosed diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2011;165(2):275-81.
2011: Hannes Findeisen; Florence Gizard; Yue Zhao; Hua Qing; Elizabeth B Heywood; Karrie L Jones; Dianne Cohn; Dennis Bruemmer
Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):851-60.
2011: Florence Gizard; Elizabeth B Heywood; Hannes Findeisen; Yue Zhao; Karrie L Jones; Céline Cudejko; Ginell R Post; Bart Staels; Dennis Bruemmer
Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(2):245-52.
2011: Hannes Findeisen; Florence Gizard; Yue Zhao; Dianne Cohn; Elizabeth B Heywood; Karrie L Jones; David H Lovett; Deborah A Howatt; Alan Daugherty; Dennis Bruemmer
Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(2):253-60.
2011: Kirk Michael Habegger; Dennis Bruemmer; Alan Daugherty; Erin Grant; Diego Perez-Tilve; Paul Pfluger; Matthias H Tschöp; Susanna M Hofmann
Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.
Frontiers in endocrinology 2011;2():67.
2011: Hannes Findeisen; Kevin J Pearson; Florence Gizard; Yue Zhao; Hua Qing; Karrie L Jones; Dianne Cohn; Elizabeth B Heywood; Rafael de Cabo; Dennis Bruemmer
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis.
PloS one 2011;6(4):e18532.
2010: Venkateswaran Subramanian; Jonathan Golledge; Talha Ijaz; Dennis Bruemmer; Alan Daugherty
Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}.
Circulation research 2010;107(8):953-8.
2010: preetha shridas; William M Bailey; Florence Gizard; Rob C Oslund; Michael H Gelb; Dennis Bruemmer; Nancy R Webb
Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(10):2014-21.
2010: Bei Zhang; Lei Chen; Karin R Swartz; Dennis Bruemmer; Sung Yong Eum; Wen Huang; Melissa Seelbach; Yean-Jung Choi; Bernhard Hennig; Michal J Toborek
Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.
Journal of neuroscience research 2010;88(13):2859-68.
2010: Yue Zhao; Deborah A Howatt; Florence Gizard; Takashi Nomiyama; Hannes Findeisen; Elizabeth B Heywood; Karrie L Jones; Orla M Conneely; Alan Daugherty; Dennis Bruemmer
Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.
Circulation research 2010;107(4):501-11.
2010: Aparna Brown; L Raymond Reynolds; Dennis Bruemmer
Intensive glycemic control and cardiovascular disease: an update.
Nature reviews. Cardiology 2010;7(7):369-75.
2010: Wen Huang; Geun Bae Rha; Lei Chen; Melissa J Seelbach; Bei Zhang; Ibolya E András; Dennis Bruemmer; Bernhard Hennig; Michal J Toborek
Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells.
American journal of physiology. Heart and circulatory physiology 2010;298(4):H1136-45.
2009: Takashi Nomiyama; Yue Zhao; Florence Gizard; Hannes Findeisen; Elizabeth B Heywood; Karrie L Jones; Orla M Conneely; Dennis Bruemmer
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.
Circulation 2009;119(4):577-86.
2008: Florence Gizard; Takashi Nomiyama; Yue Zhao; Hannes Findeisen; Elizabeth B Heywood; Karrie L Jones; Bart Staels; Dennis Bruemmer
The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
Circulation research 2008;103(10):1155-63.
2008: Peter Little; Mandy L Ballinger; Soniya Survase; Narin Osman; Esra Ogru; Stephen Geytenbeek; Dennis Bruemmer; Julie Nigro
Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis.
Journal of cardiovascular pharmacology 2008;51(3):274-9.
2008: Takashi Nomiyama; Dennis Bruemmer
Liver X receptors as therapeutic targets in metabolism and atherosclerosis.
Current atherosclerosis reports 2008;10(1):88-95.
2008: Florence Gizard; Dennis Bruemmer
Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-gamma: Therapeutic Implications for Cardiovascular Diseases.
PPAR research 2008;2008():429123.
2007: Huiyun Shen; Ruth MacDonald; Dennis Bruemmer; Arnold Stromberg; Alan Daugherty; Xiang-an Li; Michal J Toborek; Bernhard Hennig
Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone.
The Journal of nutrition 2007;137(11):2339-45.
2007: Takashi Nomiyama; Diego Perez-Tilve; Daisuke Ogawa; Florence Gizard; Yue Zhao; Elizabeth B Heywood; Karrie L Jones; Ryuzo Kawamori; Lisa A Cassis; Matthias H Tschöp; Dennis Bruemmer
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.
The Journal of clinical investigation 2007;117(10):2877-88.
2007: Takafumi Nakamachi; Takashi Nomiyama; Florence Gizard; Elizabeth B Heywood; Karrie L Jones; Yue Zhao; Lucia Fuentes; Kohzo Takebayashi; Yoshimasa Aso; Bart Staels; Toshihiko Inukai; Dennis Bruemmer
PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
Diabetes 2007;56(6):1662-70.
2006: Dennis Bruemmer
C-Peptide in insulin resistance and vascular complications: teaching an old dog new tricks.
Circulation research 2006;99(11):1149-51.
2006: Takashi Nomiyama; Takafumi Nakamachi; Florence Gizard; Elizabeth B Heywood; Karrie L Jones; Naganari Ohkura; Ryuzo Kawamori; Orla M Conneely; Dennis Bruemmer
The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.
The Journal of biological chemistry 2006;281(44):33467-76.
2006: Jian Zhong; Eckhardt Erik; Helieh S Oz; Dennis Bruemmer; Willem J S de Villiers
Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis.
Inflammatory bowel diseases 2006;12(8):790-6.
2006: Daisuke Ogawa; Takashi Nomiyama; Takafumi Nakamachi; Elizabeth B Heywood; Jeffrey F Stone; Joel P Berger; Ronald E Law; Dennis Bruemmer
Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.
Circulation research 2006;98(7):e50-9.
2005: Dennis Bruemmer; Ronald E Law
Liver x receptors: potential novel targets in cardiovascular diseases.
Current drug targets. Cardiovascular & haematological disorders 2005;5(6):533-40.
2005: Yasunori Takata; Van Chu; Alan R Collins; Christopher J Lyon; Wei Wang; Florian Blaschke; Dennis Bruemmer; Evren Caglayan; William Daley; Jitsuo Higaki; Michael C Fishbein; Rajendra K Tangirala; Ronald E Law; Willa A Hsueh
Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
Circulation research 2005;97(9):e88-96.
2005: Yi Zhao; Anna Foryst-Ludwig; Dennis Bruemmer; Juraj Culman; Michael Bader; Thomas Unger; Ulrich Kintscher
Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation.
Journal of neurochemistry 2005;94(5):1395-401.
2005: Daisuke Ogawa; Jeffrey F Stone; Yasunori Takata; Florian Blaschke; Van H Chu; Dwight A Towler; Ronald E Law; Willa A Hsueh; Dennis Bruemmer
Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways.
Circulation research 2005;96(7):e59-67.
2005: Dennis Bruemmer; Florian Blaschke; Ronald E Law
New targets for PPARgamma in the vessel wall: implications for restenosis.
International journal of obesity (2005) 2005;29 Suppl 1():S26-30.
2004: Florian Blaschke; Olli Leppanen; Yasunori Takata; Evren Caglayan; Joey Liu; Michael C Fishbein; Kai Kappert; Keiichi I Nakayama; Alan R Collins; Eckart Fleck; Willa A Hsueh; Ronald E Law; Dennis Bruemmer
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Circulation research 2004;95(12):e110-23.
2004: Florian Blaschke; Dennis Bruemmer; Fen Yin; Yasunori Takata; Wei Wang; Michael C Fishbein; Takafumi Okura; Jitsuo Higaki; Kristof Graf; Eckart Fleck; Willa A Hsueh; Ronald E Law
C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells.
Circulation 2004;110(5):579-87.
2004: Florian Blaschke; Dennis Bruemmer; Ronald E Law
Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.
Reviews in endocrine & metabolic disorders 2004;5(3):249-54.
2004: Florian Blaschke; Dennis Bruemmer; Ronald E Law
Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting?
Clinical cardiology 2004;27(7 Suppl 4):IV3-10.
2004: Fen Yin; Dennis Bruemmer; Florian Blaschke; Willa A Hsueh; Ronald E Law; Andre J Van Herle
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
Oncogene 2004;23(26):4614-23.
2004: Alan R Collins; Janet Schnee; Wei Wang; Sarah Kim; Michael C Fishbein; Dennis Bruemmer; Ronald E Law; Susanne Nicholas; Robert S Ross; Willa A Hsueh
Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.
Journal of the American College of Cardiology 2004;43(9):1698-705.
2004: Willa A Hsueh; Dennis Bruemmer
Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease.
Hypertension 2004;43(2):297-305.
2003: Dennis Bruemmer; Ronald E Law
Thiazolidinedione regulation of smooth muscle cell proliferation.
The American journal of medicine 2003;115 Suppl 8A():87S-92S.
2003: Dennis Bruemmer; Alan R Collins; Grace Noh; Wei Wang; Mary Territo; Sarah Arias-Magallona; Michael C Fishbein; Florian Blaschke; Ulrich Kintscher; Kristof Graf; Ronald E Law; Willa A Hsueh
Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
The Journal of clinical investigation 2003;112(9):1318-31.
2003: Dennis Bruemmer; Fen Yin; Joey Liu; Tohru Kiyono; Eckart Fleck; Andre J Van Herle; Ronald E Law
Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.
Experimental cell research 2003;290(1):28-37.
2003: Dennis Bruemmer; Fen Yin; Joey Liu; Joel P Berger; Toshiyuki Sakai; Florian Blaschke; Eckart Fleck; Andre J Van Herle; Barry M Forman; Ronald E Law
Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.
Circulation research 2003;93(4):e38-47.
2003: Guido Eibl; Dennis Bruemmer; Yuji Okada; John P Duffy; Ronald E Law; Howard A Reber; Oscar J Hines
PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.
Biochemical and biophysical research communications 2003;306(4):887-97.
2003: Ulrich Kintscher; Dennis Bruemmer; Florian Blaschke; Thomas Unger; Ronald E Law
p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.
Biochemical and biophysical research communications 2003;305(3):552-6.
2003: Dennis Bruemmer; Fen Yin; Joey Liu; Joel P Berger; Tohru Kiyono; Jasmine Chen; Eckart Fleck; Andre J Van Herle; Barry M Forman; Ronald E Law
Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1005-18.
2003: Stephanie T de Dios; Dennis Bruemmer; Rodney J Dilley; Melanie E Ivey; Garry L Jennings; Ronald E Law; Peter Little
Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation.
Circulation 2003;107(20):2548-50.
2003: Dennis Bruemmer; Joel P Berger; Joey Liu; Ulrich Kintscher; Shu Wakino; Eckart Fleck; David E Moller; Ronald E Law
A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth.
European journal of pharmacology 2003;466(3):225-34.
2003: Dennis Bruemmer; Fen Yin; Joey Liu; Tohru Kiyono; Eckart Fleck; Andre J Van Herle; Ronald E Law
Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells.
Biochemical and biophysical research communications 2003;303(1):251-8.
2003: Dennis Bruemmer; Fen Yin; Joey Liu; Tohru Kiyono; Eckart Fleck; Andre J Van Herle; Kristof Graf; Ronald E Law
Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.
European journal of pharmacology 2003;462(1-3):15-23.
2002: Ulrich Kintscher; Christopher Lyon; Shu Wakino; Dennis Bruemmer; Xu Feng; Stephan Goetze; Kristof Graf; Aristidis Moustakas; Bart Staels; Eckart Fleck; Willa A Hsueh; Ronald E Law
PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.
Circulation research 2002;91(11):e35-44.
2002: Mathias Knecht; Ines Pagel; Thomas Langenickel; Sebastian Philipp; Michaela Scheuermann-Freestone; Thomas E Willnow; Dennis Bruemmer; Kristof Graf; Rainer Dietz; Roland Willenbrock
Increased expression of renal neutral endopeptidase in severe heart failure.
Life sciences 2002;71(23):2701-12.
2002: Ulrich Kintscher; Shu Wakino; Dennis Bruemmer; Stephan Goetze; Kristof Graf; Willa A Hsueh; Ronald E Law
TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes.
Biochemical and biophysical research communications 2002;297(4):794-9.
2001: Stephan Goetze; Florian Blaschke; Philipp Stawowy; Dennis Bruemmer; C Spencer; Kristof Graf; Michael Gräfe; Ronald E Law; Eckart Fleck
TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells.
Biochemical and biophysical research communications 2001;287(3):662-70.
2001: Dennis Bruemmer; U Riggers; J Holzmeister; M Grill; Frank Lippek; Utz Settmacher; Vera Regitz-Zagrosek; Eckart Fleck; Kristof Graf
Expression of CD40 in vascular smooth muscle cells and macrophages is associated with early development of human atherosclerotic lesions.
The American journal of cardiology 2001;87(1):21-7.