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Geoffrey Platt

Research Profile

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Procedures

Nuclear Magnetic Resonance, Biomolecular

Disorders

Phenomena

Protein Multimerization

Co-author Network

Publications

TOP 3
Lucy A Woods; Alison E Ashcroft; Andrew L Hellewell; Eric W Hewitt; Steve W Homans; Geoffrey W Platt; Sheena E Radford
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.
Galia T Debelouchina; Geoffrey W Platt; Sheena E Radford; Marvin J Bayro; Robert G Griffin
Intermolecular alignment in β2-microglobulin amyloid fibrils.
Galia T Debelouchina; Geoffrey W Platt; Marvin J Bayro; Sheena E Radford; Robert G Griffin
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies.

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All Publications

2011: Lucy A Woods; Alison E Ashcroft; Andrew L Hellewell; Eric W Hewitt; Steve W Homans; Geoffrey W Platt; Sheena E Radford
Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.
Nature chemical biology 2011;7(10):730-9.
2010: Galia T Debelouchina; Geoffrey W Platt; Sheena E Radford; Marvin J Bayro; Robert G Griffin
Intermolecular alignment in β2-microglobulin amyloid fibrils.
Journal of the American Chemical Society 2010;132(48):17077-9.
2010: Galia T Debelouchina; Geoffrey W Platt; Marvin J Bayro; Sheena E Radford; Robert G Griffin
Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies.
Journal of the American Chemical Society 2010;132(30):10414-23.
2010: Carol L Ladner; Min Chen; David P Smith; Geoffrey W Platt; Sheena E Radford; Ralf Langen
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling.
The Journal of biological chemistry 2010;285(22):17137-47.
2009: Geoffrey W Platt; Sheena E Radford
Glimpses of the molecular mechanisms of beta2-microglobulin fibril formation in vitro: aggregation on a complex energy landscape.
FEBS letters 2009;583(16):2623-9.
2009: Katy E Routledge; Gian Gaetano Tartaglia; Geoffrey W Platt; Michele Vendruscolo; Sheena E Radford
Competition between intramolecular and intermolecular interactions in an amyloid-forming protein.
Journal of molecular biology 2009;389(4):776-86.
2009: Geoffrey W Platt; Wei-Feng Xue; Steve W Homans; Sheena E Radford
Probing dynamics within amyloid fibrils using a novel capping method.
Angewandte Chemie (International ed. in English) 2009;48(31):5705-7.
2008: Geoffrey W Platt; Katy E Routledge; Steve W Homans; Sheena E Radford
Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation.
Journal of molecular biology 2008;378(1):251-63.
2005: Sheena E Radford; Walraj S Gosal; Geoffrey W Platt
Towards an understanding of the structural molecular mechanism of beta(2)-microglobulin amyloid formation in vitro.
Biochimica et biophysica acta 2005;1753(1):51-63.
2005: Roger Bofill; Emma R Simpson; Geoffrey W Platt; Maria D Crespo; Mark S Searle
Extending the folding nucleus of ubiquitin with an independently folding beta-hairpin finger: hurdles to rapid folding arising from the stabilisation of local interactions.
Journal of molecular biology 2005;349(1):205-21.
2005: Geoffrey W Platt; Victoria J McParland; Arnout P Kalverda; Steve W Homans; Sheena E Radford
Dynamics in the unfolded state of beta2-microglobulin studied by NMR.
Journal of molecular biology 2005;346(1):279-94.
2004: Maria D Crespo; Geoffrey W Platt; Roger Bofill; Mark S Searle
Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin.
European journal of biochemistry / FEBS 2004;271(22):4474-84.
2004: Mark S Searle; Geoffrey W Platt; Roger Bofill; Stephen A Simpson; Barbara Ciani
Incremental contribution to protein stability from a beta hairpin "finger": limits on the stability of designed beta hairpin peptides.
Angewandte Chemie (International ed. in English) 2004;43(15):1991-4.
2003: Geoffrey W Platt; Stephen A Simpson; Robert Layfield; Mark S Searle
Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state.
Biochemistry 2003;42(46):13762-71.