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Maoqing Dong

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Chemicals & Drugs

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Laurence J Miller; Maoqing Dong
The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor.
Maoqing Dong; Delia I Pinon; Laurence J Miller
Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity.
Kaleeckal harikumar; Cassandra Koole; Laurence J Miller; Delia I Pinon; Alicja M Ball; Arthur Christopoulos; Maoqing Dong; Sebastian G B Furness; Bim Graham; Denise Wootten; Patrick M Sexton
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

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All Publications

2013: Laurence J Miller; Maoqing Dong
The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor.
Biochemical Society transactions 2013;41(1):154-8.
2013: Maoqing Dong; Delia I Pinon; Laurence J Miller
Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity.
Regulatory peptides 2013;180():5-11.
2012: Kaleeckal harikumar; Cassandra Koole; Laurence J Miller; Delia I Pinon; Alicja M Ball; Arthur Christopoulos; Maoqing Dong; Sebastian G B Furness; Bim Graham; Denise Wootten; Patrick M Sexton
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18607-12.
2012: Jerez A Te; Maoqing Dong; Laurence J Miller; Andrew J Bordner
Predicting the effects of amino acid replacements in peptide hormones on their binding affinities for class B GPCRs and application to the design of secretin receptor antagonists.
Journal of computer-aided molecular design 2012;26(7):835-45.
2012: Erin E Cawston; Maoqing Dong; Kaleeckal harikumar; Polo C-H Lam; Ruben Abagyan; Eyup Akgün; Mary Lou Augustine; Alicja M Ball; Andrew Orry; Philip S Portoghese; Patrick M Sexton; Laurence J Miller
Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.
The Journal of biological chemistry 2012;287(22):18618-35.
2012: Laurence J Miller; Maoqing Dong; Kaleeckal G Harikumar
Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.
British journal of pharmacology 2012;166(1):18-26.
2012: Gene L Garcia; Maoqing Dong; Laurence J Miller
Differential determinants for coupling of distinct G proteins with the class B secretin receptor.
American journal of physiology. Cell physiology 2012;302(8):C1202-12.
2011: Maoqing Dong; Andrew J Bordner; Delia I Pinon; Laura Storjohann; Jerez A Te; Jinhui Wang; Xiequn Xu; Laurence J Miller
Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.
Biochemistry 2011;50(38):8181-92.
2011: Maoqing Dong; Keiko Hosohata; Polo C-H Lam; Andrew Orry; Delia I Pinon; Patrick M Sexton; Ruben Abagyan; Laurence J Miller
Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.
The Journal of biological chemistry 2011;286(27):23888-99.
2011: Laurence J Miller; Quan Chen; Polo C-H Lam; Delia I Pinon; Patrick M Sexton; Ruben Abagyan; Maoqing Dong
Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.
The Journal of biological chemistry 2011;286(18):15895-907.
2011: Maoqing Dong; Angela Le; Jerez A Te; Delia I Pinon; Andrew J Bordner; Laurence J Miller
Importance of each residue within secretin for receptor binding and biological activity.
Biochemistry 2011;50(14):2983-93.
2010: Maoqing Dong; Delia I Pinon; Andrew J Bordner; Laurence J Miller
Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.
Bioorganic & medicinal chemistry letters 2010;20(20):6040-4.
2010: Quan Chen; Delia I Pinon; Laurence J Miller; Maoqing Dong
Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.
The Journal of biological chemistry 2010;285(32):24508-18.
2010: Quan Chen; Laurence J Miller; Maoqing Dong
Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor.
American journal of physiology. Endocrinology and metabolism 2010;299(1):E62-8.
2010: Maoqing Dong; Pooja Narang; Delia I Pinon; Andrew J Bordner; Laurence J Miller
Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides.
Peptides 2010;31(6):1094-8.
2010: Maoqing Dong; Polo C-H Lam; Delia I Pinon; Andrew Orry; Patrick M Sexton; Ruben Abagyan; Laurence J Miller
Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.
The Journal of biological chemistry 2010;285(13):9919-31.
2009: Quan Chen; Delia I Pinon; Laurence J Miller; Maoqing Dong
Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probes.
The Journal of biological chemistry 2009;284(49):34135-44.
2009: Maoqing Dong; Laurence J Miller
Effects of pH and temperature on photoaffinity labeling of Family B G protein-coupled receptors.
Regulatory peptides 2009;158(1-3):110-5.
2009: Maoqing Dong; Richard Cox; Laurence J Miller
Juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist action.
The Journal of biological chemistry 2009;284(33):21839-47.
2009: Fan Gao; Kaleeckal harikumar; Maoqing Dong; Polo C-H Lam; Patrick M Sexton; Arthur Christopoulos; Andrew Bordner; Ruben Abagyan; Laurence J Miller
Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor.
Molecular pharmacology 2009;76(2):264-74.
2009: Maoqing Dong; Polo C-H Lam; Delia I Pinon; Ruben Abagyan; Laurence J Miller
Elucidation of the molecular basis of cholecystokinin Peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modeling.
Biochemistry 2009;48(23):5303-12.
2008: Maoqing Dong; Delia I Pinon; Laurence J Miller
Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides.
Journal of molecular neuroscience : MN 2008;36(1-3):254-9.
2008: Maoqing Dong; Polo C-H Lam; Delia I Pinon; Patrick M Sexton; Ruben Abagyan; Laurence J Miller
Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.
Molecular pharmacology 2008;74(2):413-22.
2008: Maoqing Dong; Fan Gao; Delia I Pinon; Laurence J Miller
Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors.
Molecular endocrinology (Baltimore, Md.) 2008;22(6):1489-99.
2008: Hitoo Tokunaga; Bunzo Matsuura; Maoqing Dong; Laurence J Miller; Teruhisa Ueda; Shinya Furukawa; Yoichi Hiasa; Morikazu Onji
Mutational analysis of predicted intracellular loop domains of human motilin receptor.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(2):G460-6.
2007: Kaleeckal harikumar; Polo C-H Lam; Maoqing Dong; Patrick M Sexton; Ruben Abagyan; Laurence J Miller
Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.
The Journal of biological chemistry 2007;282(45):32834-43.
2007: Gregory M Hayes; patricia carrigan; Maoqing Dong; Jean Claude Reubi; Laurence J Miller
A novel secretin receptor splice variant potentially useful for early diagnosis of pancreatic carcinoma.
Gastroenterology 2007;133(3):853-61.
2007: L J Miller; Maoqing Dong; Kaleeckal harikumar; F Gao
Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.
Biochemical Society transactions 2007;35(Pt 4):709-12.
2007: Maoqing Dong; Polo C-H Lam; Fan Gao; Keiko Hosohata; Delia I Pinon; Patrick M Sexton; Ruben Abagyan; Laurence J Miller
Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.
Molecular pharmacology 2007;72(2):280-90.
2007: Maoqing Dong; Xi-Qin Ding; Scott E Thomas; Fan Gao; Polo C-H Lam; Ruben Abagyan; Laurence J Miller
Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction.
Biochemistry 2007;46(15):4522-31.
2007: Laurence J Miller; Maoqing Dong; Kaleeckal harikumar; Cayle S Lisenbee
Biochemical and cell biological mechanisms of cholecystokinin receptor regulation.
Current topics in medicinal chemistry 2007;7(12):1166-72.
2006: Kaleeckal harikumar; Maoqing Dong; Zhijie Cheng; Delia I Pinon; Terry P Lybrand; Laurence J Miller
Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function.
Biochemistry 2006;45(49):14706-16.
2006: Maoqing Dong; Laurence J Miller
Use of photoaffinity labeling to understand the molecular basis of ligand binding to the secretin receptor.
Annals of the New York Academy of Sciences 2006;1070():248-64.
2006: Maoqing Dong; Laurence J Miller
Molecular approximation between residue 10 of secretin and its receptor demonstrated by photoaffinity labeling.
Annals of the New York Academy of Sciences 2006;1070():243-7.
2006: Maoqing Dong; Delia I Pinon; Yan W Asmann; Laurence J Miller
Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors.
Molecular pharmacology 2006;70(1):206-13.
2006: Maoqing Dong; Keiko Hosohata; Delia I Pinon; Natesa Muthukumaraswamy; Laurence J Miller
Differential spatial approximation between secretin and its receptor residues in active and inactive conformations demonstrated by photoaffinity labeling.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1688-98.
2006: Bunzo Matsuura; Maoqing Dong; Shruthi Naik; Laurence J Miller; Morikazu Onji
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.
The Journal of biological chemistry 2006;281(18):12390-6.
2006: Eiji Takeshita; Bunzo Matsuura; Maoqing Dong; Laurence J Miller; Hidetaka Matsui; Morikazu Onji
Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract.
Journal of gastroenterology 2006;41(3):223-30.
2005: Vi Pham; Maoqing Dong; John D Wade; Laurence J Miller; Craig J Morton; Hooi-Ling Ng; Michael W Parker; Patrick M Sexton
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling.
The Journal of biological chemistry 2005;280(31):28610-22.
2005: Maoqing Dong; Delia I Pinon; Laurence J Miller
Insights into the structure and molecular basis of ligand docking to the G protein-coupled secretin receptor using charge-modified amino-terminal agonist probes.
Molecular endocrinology (Baltimore, Md.) 2005;19(7):1821-36.
2005: Maoqing Dong; Elizabeth M Hadac; Delia I Pinon; Laurence J Miller
Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations.
Molecular pharmacology 2005;67(6):1892-900.
2005: Bunzo Matsuura; Maoqing Dong; Bernard Coulie; Delia I Pinon; Laurence J Miller
Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1101-8.
2005: Maoqing Dong; Guangming Liu; Delia I Pinon; Laurence J Miller
Differential docking of high-affinity peptide ligands to type A and B cholecystokinin receptors demonstrated by photoaffinity labeling.
Biochemistry 2005;44(17):6693-700.
2005: Cayle S Lisenbee; Maoqing Dong; Laurence J Miller
Paired cysteine mutagenesis to establish the pattern of disulfide bonds in the functional intact secretin receptor.
The Journal of biological chemistry 2005;280(13):12330-8.
2005: Kaleeckal harikumar; Jeremy Clain; Delia I Pinon; Maoqing Dong; Laurence J Miller
Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy.
The Journal of biological chemistry 2005;280(2):1044-50.
2004: Yan W Asmann; Maoqing Dong; Laurence J Miller
Functional characterization and purification of the secretin receptor expressed in baculovirus-infected insect cells.
Regulatory peptides 2004;123(1-3):217-23.
2004: Sonnet J H Arlander; Maoqing Dong; Xi-Qin Ding; Delia I Pinon; Laurence J Miller
Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist.
Molecular pharmacology 2004;66(3):545-52.
2004: Maoqing Dong; Delia I Pinon; Richard Cox; Laurence J Miller
Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor.
The Journal of biological chemistry 2004;279(30):31177-82.
2004: Maoqing Dong; Zhijun Li; Delia I Pinon; Terry P Lybrand; Laurence J Miller
Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor.
The Journal of biological chemistry 2004;279(4):2894-903.
2004: Maoqing Dong; Delia I Pinon; Richard Cox; Laurence J Miller
Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor.
The Journal of biological chemistry 2004;279(2):1167-75.
2003: Maoqing Dong; Zhijun Li; Mengwei Zang; Delia I Pinon; Terry P Lybrand; Laurence J Miller
Spatial approximation between two residues in the mid-region of secretin and the amino terminus of its receptor. Incorporation of seven sets of such constraints into a three-dimensional model of the agonist-bound secretin receptor.
The Journal of biological chemistry 2003;278(48):48300-12.
2003: Mengwei Zang; Maoqing Dong; Delia I Pinon; Xi-Qin Ding; Elizabeth M Hadac; Zhijun Li; Terry P Lybrand; Laurence J Miller
Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor.
Molecular pharmacology 2003;63(5):993-1001.
2003: Wei-Qun Ding; Maoqing Dong; Dora Ninova; Eileen L Holicky; Mark D Stegall; Laurence J Miller
Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway.
Cellular signalling 2003;15(1):27-35.
2002: Maoqing Dong; Delia I Pinon; Laurence J Miller
Development of a biologically active secretin analogue incorporating a radioiodinatable photolabile p-(4-hydroxybenzoyl)phenylalanine in position 10.
Regulatory peptides 2002;109(1-3):181-7.
2002: Maoqing Dong; Mengwei Zang; Delia I Pinon; Zhijun Li; Terry P Lybrand; Laurence J Miller
Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.
Molecular endocrinology (Baltimore, Md.) 2002;16(11):2490-501.
2002: Bunzo Matsuura; Maoqing Dong; Laurence J Miller
Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action.
The Journal of biological chemistry 2002;277(12):9834-9.
2002: Maoqing Dong; Laurence J Miller
Molecular pharmacology of the secretin receptor.
Receptors & channels 2002;8(3-4):189-200.
2001: Bernard Coulie; Bunzo Matsuura; Maoqing Dong; Elizabeth M Hadac; Delia I Pinon; Scott Feighner; Andrew D Howard; Laurence J Miller
Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.
The Journal of biological chemistry 2001;276(38):35518-22.
2001: Shi-Wen (Albert) Jiang; Maoqing Dong; Miguel A Trujillo; L J Miller; Norman L Eberhardt
DNA binding of TEA/ATTS domain factors is regulated by protein kinase C phosphorylation in human choriocarcinoma cells.
The Journal of biological chemistry 2001;276(26):23464-70.
2000: Yan W Asmann; Maoqing Dong; SC Ganguli; Elizabeth M Hadac; Laurence J Miller
Structural insights into the amino-terminus of the secretin receptor: I. Status of cysteine and cystine residues.
Molecular pharmacology 2000;58(5):911-9.
2000: Maoqing Dong; Yan W Asmann; Mengwei Zang; Delia I Pinon; Laurence J Miller
Identification of two pairs of spatially approximated residues within the carboxyl terminus of secretin and its receptor.
The Journal of biological chemistry 2000;275(34):26032-9.
2000: Maoqing Dong; Y Wang; Laurence J Miller
Dual contacts between peptide agonist ligands and the secretin receptor directly established by photoaffinity labeling.
Annals of the New York Academy of Sciences 2000;921():381-6.
1999: Maoqing Dong; Y Wang; Elizabeth M Hadac; Delia I Pinon; Eileen L Holicky; Laurence J Miller
Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor.
The Journal of biological chemistry 1999;274(27):19161-7.
1999: Maoqing Dong; Xi-Qin Ding; Delia I Pinon; Elizabeth M Hadac; R P Oda; J P Landers; Laurence J Miller
Structurally related peptide agonist, partial agonist, and antagonist occupy a similar binding pocket within the cholecystokinin receptor. Rapid analysis using fluorescent photoaffinity labeling probes and capillary electrophoresis.
The Journal of biological chemistry 1999;274(8):4778-85.
1999: Maoqing Dong; Y Wang; Delia I Pinon; Elizabeth M Hadac; Laurence J Miller
Demonstration of a direct interaction between residue 22 in the carboxyl-terminal half of secretin and the amino-terminal tail of the secretin receptor using photoaffinity labeling.
The Journal of biological chemistry 1999;274(2):903-9.
1999: F Li; Maoqing Dong; L J Miller; S Naylor
Efficient removal of sodium dodecyl sulfate (SDS) enhances analysis of proteins by SDS-polyacrylamide gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 1999;13(5):464-5.
1998: Loris G Baggetto; Maoqing Dong; Janine Bernaud; Leon Espinosa; Dominique Rigal; Robert Bonvallet; Eric Marthinet
In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin.
Biochemical pharmacology 1998;56(9):1219-28.
1998: Maoqing Dong; L Ladavière; François Penin; Gilbert Deléage; Loris G Baggetto
Secondary structure of P-glycoprotein investigated by circular dichroism and amino acid sequence analysis.
Biochimica et biophysica acta 1998;1371(2):317-34.
1997: Maoqing Dong; RP Oda; Michael A Strausbauch; Peter J Wettstein; JP Landers; Laurence J Miller
Hydrophobic peptide mapping of clinically relevant heptathelical membrane proteins by capillary electrophoresis.
Electrophoresis 1997;18(10):1767-74.
1997: Maoqing Dong; Loris G Baggetto; Pierre Falson; Marc le Maire; François Penin
Complete removal and exchange of sodium dodecyl sulfate bound to soluble and membrane proteins and restoration of their activities, using ceramic hydroxyapatite chromatography.
Analytical biochemistry 1997;247(2):333-41.
1996: Maoqing Dong; François Penin; Loris G Baggetto
Efficient purification and reconstitution of P-glycoprotein for functional and structural studies.
The Journal of biological chemistry 1996;271(46):28875-83.