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Jennifer S. Isaacs

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Disorders

Renal Cell Carcinoma

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Publications

TOP 3
Michael W Hance; Agnieszka Jezierska-Drutel; Haibo Liu; Carola A Neumann; Jessica E Bohonowych; Krystal Dole; Isla P Garraway; Udhayakumar Gopal; Jennifer S. Isaacs
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
Jessica E S Bohonowych; Udhayakumar Gopal; Michael W Hance; Karen Lundgren; Shuping Peng; Shane B Wing; Kelley M Argraves; Jennifer S. Isaacs
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Udhayakumar Gopal; Jessica E Bohonowych; Carla Lema-Tome; Angen Liu; Elizabeth Garrett-Mayer; Bingcheng Wang; Jennifer S. Isaacs
A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

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All Publications

2012: Michael W Hance; Agnieszka Jezierska-Drutel; Haibo Liu; Carola A Neumann; Jessica E Bohonowych; Krystal Dole; Isla P Garraway; Udhayakumar Gopal; Jennifer S. Isaacs
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
The Journal of biological chemistry 2012;287(45):37732-44.
2011: Jessica E S Bohonowych; Udhayakumar Gopal; Michael W Hance; Karen Lundgren; Shuping Peng; Shane B Wing; Kelley M Argraves; Jennifer S. Isaacs
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
BMC cancer 2011;11():520.
2011: Udhayakumar Gopal; Jessica E Bohonowych; Carla Lema-Tome; Angen Liu; Elizabeth Garrett-Mayer; Bingcheng Wang; Jennifer S. Isaacs
A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.
PloS one 2011;6(3):e17649.
2010: Zhiqiang Qin; Michael DeFee; Jennifer S. Isaacs; Chris Parsons
Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.
Virology 2010;403(1):92-102.
2010: J E Bohonowych; U Gopal; Jennifer S. Isaacs
Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.
Journal of oncology 2010;2010():412985.
2009: Balasubramaniam Annamalai; Xueguang Liu; Udhayakumar Gopal; Jennifer S. Isaacs
Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.
Molecular cancer research : MCR 2009;7(7):1021-32.
2006: Hyo Jin Kang; Hee Jeong Kim; Jeong-Keun Rih; Thomas L Mattson; Kyu Won Kim; Chi-Heum Cho; Jennifer S. Isaacs; Insoo Bae
BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression.
The Journal of biological chemistry 2006;281(19):13047-56.
2005: Jennifer S. Isaacs; Yun Jin Jung; David R Mole; Sunmin Lee; Carlos Torres-Cabala; Yuen-Li Chung; Maria Merino; Jane Trepel; Berton Zbar; Jorge Toro; Peter J Ratcliffe; W Marston Linehan; Len Neckers
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Cancer cell 2005;8(2):143-53.
2005: Jennifer S. Isaacs
Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?
Expert opinion on investigational drugs 2005;14(6):569-89.
2004: W Marston Linehan; James R Vasselli; Ramaprasad Srinivasan; McClellan Walther; Maria Merino; Peter Choyke; Cathy D Vocke; Laura Schmidt; Jennifer S. Isaacs; Gladys Glenn; Jorge Toro; Berton Zbar; Donald Bottaro; Len Neckers
Genetic basis of cancer of the kidney: disease-specific approaches to therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 2):6282S-9S.
2004: Edward G Mimnaugh; Wanping Xu; Michele Vos; Xitong Yuan; Jennifer S. Isaacs; Kheem S Bisht; David Gius; Len Neckers
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
Molecular cancer therapeutics 2004;3(5):551-66.
2004: Jennifer S. Isaacs; Yun-Jin Jung; Len Neckers
Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway.
The Journal of biological chemistry 2004;279(16):16128-35.
2003: Kheem S Bisht; C Matthew Bradbury; David Mattson; Aradhana Kaushal; Anastasia L Sowers; Stephanie Markovina; Karen L Ortiz; Leah K Sieck; Jennifer S. Isaacs; Martin W Brechbiel; James B Mitchell; Leonard M Neckers; David Gius
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Cancer research 2003;63(24):8984-95.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2115-7.
2003: YunJin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Zheng-Gang Liu; Len Neckers
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.
The Biochemical journal 2003;370(Pt 3):1011-7.
2003: Jennifer S. Isaacs; Wanping Xu; Len Neckers
Heat shock protein 90 as a molecular target for cancer therapeutics.
Cancer cell 2003;3(3):213-7.
2003: Yun-Jin Jung; Jennifer S. Isaacs; Sunmin Lee; Jane Trepel; Len Neckers
Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein.
The Journal of biological chemistry 2003;278(9):7445-52.
2002: Jennifer S. Isaacs; Yun-Jin Jung; Edward G Mimnaugh; Alfredo Martinez; Frank Cuttitta; Leonard M Neckers
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.
The Journal of biological chemistry 2002;277(33):29936-44.
2001: Jennifer S. Isaacs; S Saito; Leonard M Neckers
Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma.
The Journal of biological chemistry 2001;276(21):18497-506.
1999: B A Burkhart; D A Alcorta; C Chiao; Jennifer S. Isaacs; J Carl Barrett
Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence.
Experimental cell research 1999;247(1):168-75.
1999: Jennifer S. Isaacs; J Carl Barrett; Bernard E Weissman
Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6-mediated degradation.
Molecular carcinogenesis 1999;24(1):70-7.
1998: Jennifer S. Isaacs; R Hardman; T A Carman; J Carl Barrett; Bernard E Weissman
Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(7):545-55.
1997: Jennifer S. Isaacs; C Chiao; B Alex Merrick; James K Selkirk; J Carl Barrett; Bernard E Weissman
p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral neuroepithelioma cell line.
Cancer research 1997;57(14):2986-92.
1997: Jennifer S. Isaacs; P Chen; A Garza; M F Hansen; J Carl Barrett; Bernard E Weissman
Failure of HPV E6 to rapidly degrade p53 in human HeLa x PNET cell hybrids.
Oncogene 1997;14(14):1669-78.