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Thomas MacDonald

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
42
Monteleone, Giovanni
28
Pender, Sylvia
25
Pallone, Francesco
17
Walker-Smith, John
17
Murch, Simon
16
Caruso, Roberta
15
Fina, Daniele
12
Fantini, Massimo
11
Di Sabatino, Antonio
11
Frankel, Gad
10
Gordon, John
10
Del Vecchio Blanco, Giovanna
10
Stolfi, Carmine
9
Bajaj-Elliott, M
8
Dougan, Gordon

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Publications

TOP 3
Di Sabatino Antonio; Rovedatti Laura; Kaur Rejbinder; Spencer Jonathan P; Brown Jon T; Morisset Valerie D; Biancheri Paolo; Leakey Nicholas A B; Wilde Jonathan I; Scott Laurie; Corazza Gino R; Lee Kevin; Sengupta Neel; Knowles Charles H; Gunthorpe Martin J; McLean Peter G; MacDonald Thomas T; Kruidenier Laurens
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease.
Di Sabatino Antonio; Saarialho-Kere Ulpu; Buckley Mark G; Gordon John N; Biancheri Paolo; Rovedatti Laura; Corazza Gino R; Macdonald Thomas T; Pender Sylvia L F
Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab.
Monteleone Giovanni; Pallone Francesco; Macdonald Thomas T
Interleukin-21 as a new therapeutic target for immune-mediated diseases.

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All Publications

2009: Di Sabatino Antonio; Rovedatti Laura; Kaur Rejbinder; Spencer Jonathan P; Brown Jon T; Morisset Valerie D; Biancheri Paolo; Leakey Nicholas A B; Wilde Jonathan I; Scott Laurie; Corazza Gino R; Lee Kevin; Sengupta Neel; Knowles Charles H; Gunthorpe Martin J; McLean Peter G; MacDonald Thomas T; Kruidenier Laurens
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3454-62.
2009: Di Sabatino Antonio; Saarialho-Kere Ulpu; Buckley Mark G; Gordon John N; Biancheri Paolo; Rovedatti Laura; Corazza Gino R; Macdonald Thomas T; Pender Sylvia L F
Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab.
European journal of gastroenterology & hepatology 2009;21(9):1049-55.
2009: Monteleone Giovanni; Pallone Francesco; Macdonald Thomas T
Interleukin-21 as a new therapeutic target for immune-mediated diseases.
Trends in pharmacological sciences 2009;30(8):441-7.
2009: MacDonald Thomas T; Voessenkamper Anna; Di Sabatino Antonio
Antigen presenting cells and T cell interactions in the gastrointestinal tract.
Molecular nutrition & food research 2009;53(8):947-51.
2009: Caruso Roberta; Sarra Massimiliano; Stolfi Carmine; Rizzo Angelamaria; Fina Daniele; Fantini Massimo Claudio; Pallone Francesco; MacDonald Thomas T; Monteleone Giovanni
Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut.
Gastroenterology 2009;136(7):2270-9.
2009: Di Sabatino A; Jackson C L; Pickard K M; Buckley M; Rovedatti L; Leakey N A B; Picariello L; Cazzola P; Monteleone G; Tonelli F; Corazza G R; MacDonald T T; Pender S L
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures.
Gut 2009;58(6):777-89.
2009: Di Sabatino Antonio; Rovedatti Laura; Rosado Manuela M; Carsetti Rita; Corazza Gino R; MacDonald Thomas T
Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood.
Human pathology 2009;40(5):699-704.
2009: Monteleone Giovanni; Pallone Francesco; Macdonald Thomas T
Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease.
Cytokine & growth factor reviews 2009;20(2):185-91.
2009: Fantini Massimo C; Rizzo Angelamaria; Fina Daniele; Caruso Roberta; Sarra Massimiliano; Stolfi Carmine; Becker Christoph; Macdonald Thomas T; Pallone Francesco; Neurath Markus F; Monteleone Giovanni
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.
Gastroenterology 2009;136(4):1308-16, e1-3.
2009: Caruso Roberta; Stolfi Carmine; Sarra Massimiliano; Rizzo Angelamaria; Fantini Massimo C; Pallone Francesco; MacDonald Thomas T; Monteleone Giovanni
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Blood 2009;113(15):3512-9.
2009: Chuang S-L; Hayes P J; Ogundipe E; Haddad M; MacDonald T T; Fell J M
Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2009;20(1):45-52.
2008: Hemrajani Cordula; Marches Olivier; Wiles Siouxsie; Girard Francis; Dennis Alison; Dziva Francis; Best Angus; Phillips Alan D; Berger Cedric N; Mousnier Aurelie; Crepin Valerie F; Kruidenier Laurens; Woodward Martin J; Stevens Mark P; La Ragione Roberto M; MacDonald Thomas T; Frankel Gad
Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.
Infection and immunity 2008;76(11):4804-13.
2008: Dennis Alison; Kudo Takahiro; Kruidenier Laurens; Girard Francis; Crepin Valerie F; MacDonald Thomas T; Frankel Gad; Wiles Siouxsie
The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.
Infection and immunity 2008;76(11):4978-88.
2008: Fina D; Sarra M; Caruso R; Del Vecchio Blanco G; Pallone F; MacDonald T T; Monteleone G
Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease.
Gut 2008;57(7):887-92.
2008: Monteleone Giovanni; Pallone Francesco; MacDonald Thomas T
Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses.
Trends in immunology 2008;29(6):290-4.
2008: Di Sabatino A; Pickard K M; Rampton D; Kruidenier L; Rovedatti L; Leakey N A B; Corazza G R; Monteleone G; MacDonald T T
Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa.
Gut 2008;57(5):605-12.
2008: Fina Daniele; Sarra Massimiliano; Fantini Massimo C; Rizzo Angelamaria; Caruso Roberta; Caprioli Flavio; Stolfi Carmine; Cardolini Iris; Dottori Marta; Boirivant Monica; Pallone Francesco; Macdonald Thomas T; Monteleone Giovanni
Regulation of gut inflammation and th17 cell response by interleukin-21.
Gastroenterology 2008;134(4):1038-48.
2008: Caprioli Flavio; Sarra Massimiliano; Caruso Roberta; Stolfi Carmine; Fina Daniele; Sica Giuseppe; MacDonald Thomas T; Pallone Francesco; Monteleone Giovanni
Autocrine regulation of IL-21 production in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1800-7.
2008: Caruso Roberta; Fina Daniele; Paoluzi Omero Alessandro; Del Vecchio Blanco Giovanna; Stolfi Carmine; Rizzo Angelamaria; Caprioli Flavio; Sarra Massimiliano; Andrei Fabio; Fantini Massimo Claudio; MacDonald Thomas T; Pallone Francesco; Monteleone Giovanni
IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa.
European journal of immunology 2008;38(2):470-8.
2008: Gordon John N; Pickard Karen M; Di Sabatino Antonio; Prothero Joanna D; Pender Sylvia L F; Goggin Patrick M; MacDonald Thomas T
Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease.
Inflammatory bowel diseases 2008;14(2):195-203.
2007: Fantini Massimo C; Rizzo Agelamaria; Fina Daniele; Caruso Roberta; Becker Christoph; Neurath Markus F; Macdonald Thomas T; Pallone Francesco; Monteleone Giovanni
IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.
European journal of immunology 2007;37(11):3155-63.
2007: Fantini Massimo C; Monteleone Giovanni; Macdonald Thomas T
New players in the cytokine orchestra of inflammatory bowel disease.
Inflammatory bowel diseases 2007;13(11):1419-23.
2007: Di Sabatino Antonio; Pickard Karen M; Gordon John N; Salvati Virginia; Mazzarella Giuseppe; Beattie Robert M; Vossenkaemper Anna; Rovedatti Laura; Leakey Nicholas A B; Croft Nicholas M; Troncone Riccardo; Corazza Gino R; Stagg Andrew J; Monteleone Giovanni; MacDonald Thomas T
Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease.
Gastroenterology 2007;133(4):1175-87.
2007: Di Sabatino Antonio; Pender Sylvia L F; Jackson Claire L; Prothero Joanna D; Gordon John N; Picariello Lucia; Rovedatti Laura; Docena Guillermo; Monteleone Giovanni; Rampton David S; Tonelli Francesco; Corazza Gino R; MacDonald Thomas T
Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies.
Gastroenterology 2007;133(1):137-49.
2007: Caruso Roberta; Fina Daniele; Peluso Ilaria; Fantini Massimo Claudio; Tosti Claudio; Del Vecchio Blanco Giovanna; Paoluzi Omero Alessandro; Caprioli Flavio; Andrei Fabio; Stolfi Carmine; Romano Marco; Ricci Vittorio; MacDonald Thomas T; Pallone Francesco; Monteleone Giovanni
IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5957-65.
2007: Caruso Roberta; Fina Daniele; Peluso Ilaria; Stolfi Carmine; Fantini Massimo Claudio; Gioia Valentina; Caprioli Flavio; Del Vecchio Blanco Giovanna; Paoluzi Omero Alessandro; Macdonald Thomas T; Pallone Francesco; Monteleone Giovanni
A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.
Gastroenterology 2007;132(1):166-75.
2007: Peluso Ilaria; Fantini Massimo Claudio; Fina Daniele; Caruso Roberta; Boirivant Monica; MacDonald Thomas T; Pallone Francesco; Monteleone Giovanni
IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):732-9.
2006: Boirivant Monica; Pallone Francesco; Di Giacinto Claudia; Fina Daniele; Monteleone Ivan; Marinaro Mariarosaria; Caruso Roberta; Colantoni Alfredo; Palmieri Giampiero; Sanchez Massimo; Strober Warren; MacDonald Thomas T; Monteleone Giovanni
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.
Gastroenterology 2006;131(6):1786-98.
2006: Monteleone G; Caruso R; Fina D; Peluso I; Gioia V; Stolfi C; Fantini M C; Caprioli F; Tersigni R; Alessandroni L; MacDonald T T; Pallone F
Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.
Gut 2006;55(12):1774-80.
2006: Wiles Siouxsie; Pickard Karen M; Peng Katian; MacDonald Thomas T; Frankel Gad
In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium.
Infection and immunity 2006;74(9):5391-6.
2006: Pender Sylvia L F; Li C K F; Di Sabatino A; MacDonald T T; Buckley M G
Role of macrophage metalloelastase in gut inflammation.
Annals of the New York Academy of Sciences 2006;1072():386-8.
2006: Caruso Roberta; Pallone Francesco; Fina Daniele; Gioia Valentina; Peluso Ilaria; Caprioli Flavio; Stolfi Carmine; Perfetti Alessandra; Spagnoli Luigi Giusto; Palmieri Giampiero; Macdonald Thomas T; Monteleone Giovanni
Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation.
The American journal of pathology 2006;169(1):268-78.
2006: MacDonald Thomas T; Monteleone Giovanni
Overview of role of the immune system in the pathogenesis of inflammatory bowel disease.
Advances in experimental medicine and biology 2006;579():98-107.
2005: Mundy Rosanna; MacDonald Thomas T; Dougan Gordon; Frankel Gad; Wiles Siouxsie
Citrobacter rodentium of mice and man.
Cellular microbiology 2005;7(12):1697-706.
2005: Monteleone Giovanni; Del Vecchio Blanco Giovanna; Monteleone Ivan; Fina Daniele; Caruso Roberta; Gioia Valentina; Ballerini Sabrina; Federici Giorgio; Bernardini Sergio; Pallone Francesco; MacDonald Thomas T
Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.
Gastroenterology 2005;129(5):1420-9.
2005: Gordon J N; MacDonald T T
Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease.
Gut 2005;54(9):1213-5.
2005: MacDonald Thomas T; Gordon John N
Bacterial regulation of intestinal immune responses.
Gastroenterology clinics of North America 2005;34(3):401-12, vii-viii.
2005: Prasad Shyam; Mingrino Roberto; Kaukinen Katri; Hayes Katherine L; Powell Robert M; MacDonald Thomas T; Collins Jane E
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Laboratory investigation; a journal of technical methods and pathology 2005;85(9):1139-62.
2005: Pender S L-F; Chance V; Whiting C V; Buckley M; Edwards M; Pettipher R; MacDonald T T
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.
Gut 2005;54(8):1114-20.
2005: MacDonald Thomas T; Di Sabatino Antonio; Gordon John N
Immunopathogenesis of Crohn's disease.
JPEN. Journal of parenteral and enteral nutrition 2005;29(4 Suppl):S118-24; discussion S124-5, S184-8.
2005: Gordon John N; Di Sabatino Antonio; Macdonald Thomas T
The pathophysiologic rationale for biological therapies in inflammatory bowel disease.
Current opinion in gastroenterology 2005;21(4):431-7.
2005: Brittan Mairi; Chance Victoria; Elia George; Poulsom Richard; Alison Malcolm R; MacDonald Thomas T; Wright Nicholas A
A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.
Gastroenterology 2005;128(7):1984-95.
2005: Gunther Ute; Holloway Judith A; Gordon John N; Knight Andrea; Chance Victoria; Hanley Neil A; Wilson David I; French Ruth; Spencer Jo; Steer Howard; Anderson Graham; MacDonald Thomas T
Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5414-22.
2005: Macdonald Thomas T; Monteleone Giovanni
Immunity, inflammation, and allergy in the gut.
Science (New York, N.Y.) 2005;307(5717):1920-5.
2005: Monteleone Giovanni; Monteleone Ivan; Fina Daniele; Vavassori Piero; Del Vecchio Blanco Giovanna; Caruso Roberta; Tersigni Roberto; Alessandroni Luciano; Biancone Livia; Naccari Gian Carlo; MacDonald Thomas T; Pallone Francesco
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease.
Gastroenterology 2005;128(3):687-94.
2004: Pender Sylvia L F; MacDonald Thomas T
Matrix metalloproteinases and the gut - new roles for old enzymes.
Current opinion in pharmacology 2004;4(6):546-50.
2004: Salmela M T; Pender S L F; Karjalainen-Lindsberg M-L; Puolakkainen P; Macdonald T T; Saarialho-Kere U
Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing.
Scandinavian journal of gastroenterology 2004;39(11):1095-104.
2004: Li Chris K F; Pender Sylvia L F; Pickard Karen M; Chance Victoria; Holloway Judith A; Huett Alan; Gonçalves Nathalie S; Mudgett John S; Dougan Gordon; Frankel Gad; MacDonald Thomas T
Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5171-9.
2004: Monteleone Giovanni; Pallone Francesco; MacDonald Thomas T
Smad7 in TGF-beta-mediated negative regulation of gut inflammation.
Trends in immunology 2004;25(10):513-7.
2004: Monteleone I; Monteleone G; Del Vecchio Blanco G; Vavassori P; Cucchiara S; MacDonald T T; Pallone F
Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa.
Gut 2004;53(8):1090-5.
2004: Pickard Karen M; Bremner A Ronald; Gordon John N; MacDonald Thomas T
Microbial-gut interactions in health and disease. Immune responses.
Best practice & research. Clinical gastroenterology 2004;18(2):271-85.
2004: Monteleone Giovanni; Del Vecchio Blanco Giovanna; Palmieri Giampiero; Vavassori Piero; Monteleone Ivan; Colantoni Alfredo; Battista Serena; Spagnoli Luigi Giusto; Romano Marco; Borrelli Melissa; MacDonald Thomas T; Pallone Francesco
Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection.
Gastroenterology 2004;126(3):674-82.
2004: Monteleone Giovanni; Mann Jelena; Monteleone Ivan; Vavassori Piero; Bremner Ronald; Fantini Massimo; Del Vecchio Blanco Giovanna; Tersigni Roberto; Alessandroni Luciano; Mann Derek; Pallone Francesco; MacDonald Thomas T
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation.
The Journal of biological chemistry 2004;279(6):3925-32.
2003: Gordon J N; MacDonald T T
Biological therapy in Crohn's disease.
Hospital medicine (London, England : 1998) 2003;64(12):708-12.
2003: Simmons Cameron P; Clare Simon; Ghaem-Maghami Marjan; Uren Tania K; Rankin Joanna; Huett Allan; Goldin Rob; Lewis David J; MacDonald Thomas T; Strugnell Richard A; Frankel Gad; Dougan Gordon
Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium.
Infection and immunity 2003;71(9):5077-86.
2003: Salvati Virginia M; MacDonald Thomas T; del Vecchio Blanco Giovanna; Mazzarella Giuseppe; Monteleone Ivan; Vavassori Piero; Auricchio Salvatore; Pallone Francesco; Troncone Riccardo; Monteleone Giovanni
Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease.
Pediatric research 2003;54(3):312-8.
2003: Pender Sylvia Lin Foon; Braegger Christian; Gunther Ute; Monteleone Giovanni; Meuli Martin; Schuppan Detlef; Macdonald Thomas Thornton
Matrix metalloproteinases in necrotising enterocolitis.
Pediatric research 2003;54(2):160-4.
2003: Mazzarella Giuseppe; MacDonald Thomas T; Salvati Virginia M; Mulligan Peter; Pasquale Luigi; Stefanile Rosita; Lionetti Paolo; Auricchio Salvatore; Pallone Francesco; Troncone Riccardo; Monteleone Giovanni
Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions.
The American journal of pathology 2003;162(6):1845-55.
2003: MacDonald Thomas T
The mucosal immune system.
Parasite immunology 2003;25(5):235-46.
2003: Gonçalves Nathalie S; Hale Christine; Dougan Gordon; Frankel Gad; MacDonald Thomas T
Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.
Infection and immunity 2003;71(5):2960-5.
2003: MacDonald Thomas T; Frankel Gad; Dougan Gordon; Goncalves Nathalie S; Simmons Cameron
Host defences to Citrobacter rodentium.
International journal of medical microbiology : IJMM 2003;293(1):87-93.
2003: Monteleone Giovanni; Holloway Judith; Salvati Virginia M; Pender Sylvia L-F; Fairclough Peter D; Croft Nicholas; MacDonald Thomas T
Activated STAT4 and a functional role for IL-12 in human Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):300-7.
2002: Salmela M T; MacDonald T T; Black D; Irvine B; Zhuma T; Saarialho-Kere U; Pender S L F
Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation.
Gut 2002;51(4):540-7.
2002: MacDonald T T
Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers.
Gut 2002;51(3):311-2.
2002: Simmons Cameron P; Goncalves Nathalie S; Ghaem-Maghami Marjan; Bajaj-Elliott Mona; Clare Simon; Neves Bianca; Frankel Gad; Dougan Gordon; MacDonald Thomas T
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1804-12.
2002: Salvati V M; MacDonald T T; Bajaj-Elliott M; Borrelli M; Staiano A; Auricchio S; Troncone R; Monteleone G
Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.
Gut 2002;50(2):186-90.
2001: Gonçalves N S; Ghaem-Maghami M; Monteleone G; Frankel G; Dougan G; Lewis D J; Simmons C P; MacDonald T T
Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis.
Infection and immunity 2001;69(11):6651-9.
2001: Monteleone G; Kumberova A; Croft N M; McKenzie C; Steer H W; MacDonald T T
Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease.
The Journal of clinical investigation 2001;108(4):601-9.
2001: Jones C A; Vance G H; Power L L; Pender S L; Macdonald T T; Warner J O
Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming.
The Journal of allergy and clinical immunology 2001;108(2):235-41.
2001: Monteleone G; Pender S L; Wathen N C; MacDonald T T
Interferon-alpha drives T cell-mediated immunopathology in the intestine.
European journal of immunology 2001;31(8):2247-55.
2001: Salvati V M; Bajaj-Elliott M; Poulsom R; Mazzarella G; Lundin K E; Nilsen E M; Troncone R; MacDonald T T
Keratinocyte growth factor and coeliac disease.
Gut 2001;49(2):176-81.
2001: MacDonald T T; Monteleone G
IL-12 and Th1 immune responses in human Peyer's patches.
Trends in immunology 2001;22(5):244-7.
2001: Macdonald T T
The worm turns on Helicobacter pylori.
Gut 2001;48(1):10-1.
2000: Pender S L; Salmela M T; Monteleone G; Schnapp D; McKenzie C; Spencer J; Fong S; Saarialho-Kere U; MacDonald T T
Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype.
The American journal of pathology 2000;157(6):1955-62.
2000: Pender S L; Quinn J J; Sanderson I R; MacDonald T T
Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(5):G918-24.
2000: Nagata S; McKenzie C; Pender S L; Bajaj-Elliott M; Fairclough P D; Walker-Smith J A; Monteleone G; MacDonald T T
Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5315-21.
2000: Hartland E L; Huter V; Higgins L M; Goncalves N S; Dougan G; Phillips A D; MacDonald T T; Frankel G
Expression of intimin gamma from enterohemorrhagic Escherichia coli in Citrobacter rodentium.
Infection and immunity 2000;68(8):4637-46.
2000: Heuschkel R B; MacDonald T T; Monteleone G; Bajaj-Elliott M; Smith J A; Pender S L
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease.
Gut 2000;47(1):57-62.
2000: MacDonald T T; Pettersson S
Bacterial regulation of intestinal immune responses.
Inflammatory bowel diseases 2000;6(2):116-22.
2000: Fell J M; Paintin M; Arnaud-Battandier F; Beattie R M; Hollis A; Kitching P; Donnet-Hughes A; MacDonald T T; Walker-Smith J A
Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease.
Alimentary pharmacology & therapeutics 2000;14(3):281-9.
1999: Monteleone G; MacDonald T T; Wathen N C; Pallone F; Pender S L
Enhancing Lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury.
Gastroenterology 1999;117(5):1069-77.
1999: MacDonald T T; Bajaj-Elliott M; Pender S L
T cells orchestrate intestinal mucosal shape and integrity.
Immunology today 1999;20(11):505-10.
1999: Higgins L M; Frankel G; Connerton I; Gonçalves N S; Dougan G; MacDonald T T
Role of bacterial intimin in colonic hyperplasia and inflammation.
Science (New York, N.Y.) 1999;285(5427):588-91.
1999: Pender S L; McKenzie C; Shaida A; MacDonald T T
Regulation of matrix metalloproteinases in human intestinal mucosa.
Annals of the New York Academy of Sciences 1999;878():581-2.
1999: Higgins L M; Frankel G; Douce G; Dougan G; MacDonald T T
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease.
Infection and immunity 1999;67(6):3031-9.
1999: Higgins L M; McDonald S A; Whittle N; Crockett N; Shields J G; MacDonald T T
Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):486-93.
1999: Fell J M; Paintin M; Donnet-Hughes A; Arnaud-Battandier F; MacDonald T T; Walker-Smith J A
Remission induced by a new specific oral polymeric diet in children with Crohn's disease.
Nestlé Nutrition workshop series. Clinical & performance programme 1999;2():187-96; discussion 196-8.
1999: MacDonald T T
Effector and regulatory lymphoid cells and cytokines in mucosal sites.
Current topics in microbiology and immunology 1999;236():113-35.
1998: Howie D; Spencer J; DeLord D; Pitzalis C; Wathen N C; Dogan A; Akbar A; MacDonald T T
Extrathymic T cell differentiation in the human intestine early in life.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5862-72.
1998: MacDonald T T
Depletion of the enteric nervous system by gene targeting results in haemorrhagic necrosis of the ileum.
Gut 1998;43(6):742-3.
1998: Pender S L; MacDonald T T
Regulation of matrix metalloproteinase production in human fetal intestinal mesenchymal cells by cytokines and the bacterial superantigen Staphylococcus aureus enterotoxin B.
Annals of the New York Academy of Sciences 1998;859():188-91.
1998: Bajaj-Elliott M; Pender S L; Poulsom R; Macdonald T T
Upregulation of keratinocyte growth factor during T-cell immunity in the gut mucosa.
Annals of the New York Academy of Sciences 1998;859():184-7.
1998: Bajaj-Elliott M; Poulsom R; Pender S L; Wathen N C; MacDonald T T
Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.
The Journal of clinical investigation 1998;102(8):1473-80.
1998: Pender S L; Breese E J; Günther U; Howie D; Wathen N C; Schuppan D; MacDonald T T
Suppression of T cell-mediated injury in human gut by interleukin 10: role of matrix metalloproteinases.
Gastroenterology 1998;115(3):573-83.
1998: Hauer A C; Bajaj-Elliott M; Williams C B; Walker-Smith J A; MacDonald T T
An analysis of interferon gamma, IL-4, IL-5 and IL-10 production by ELISPOT and quantitative reverse transcriptase-PCR in human Peyer's patches.
Cytokine 1998;10(8):627-34.
1998: MacDonald T T; Pender S L
Proteolytic enzymes in inflammatory bowel disease.
Inflammatory bowel diseases 1998;4(2):157-64.
1998: Macdonald T T
Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease.
Gut 1998;42(4):460-1.
1998: Pender S L; Fell J M; Chamow S M; Ashkenazi A; MacDonald T T
A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):4098-103.
1997: Hauer A C; Finn T M; MacDonald T T; Spencer J; Isaacson P G
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
Journal of clinical pathology 1997;50(11):957-9.
1997: MacDonald T T
Cytokine gene deleted mice in the study of gastrointestinal inflammation.
European journal of gastroenterology & hepatology 1997;9(11):1051-5.
1997: Bajaj-Elliott M; Breese E; Poulsom R; Fairclough P D; MacDonald T T
Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.
The American journal of pathology 1997;151(5):1469-76.
1997: Hauer A C; Breese E J; Walker-Smith J A; MacDonald T T
The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity.
Pediatric research 1997;42(5):629-38.
1997: McDonald S A; Palmen M J; Van Rees E P; MacDonald T T
Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis.
Immunology 1997;91(1):73-80.
1997: MacDonald T T
Oxpentifylline, tumour necrosis factor-alpha and Crohn's disease.
Gut 1997;40(4):559.
1997: Pender S L; Tickle S P; Docherty A J; Howie D; Wathen N C; MacDonald T T
A major role for matrix metalloproteinases in T cell injury in the gut.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1582-90.
1996: Penney I; Kilshaw P J; MacDonald T T
Increased division of alpha beta TCR+ and gamma delta TCR+ intestinal intraepithelial lymphocytes after oral administration of cholera toxin.
Immunology 1996;89(1):54-8.
1996: Murch S H; Costeloe K; Klein N J; MacDonald T T
Early production of macrophage inflammatory protein-1 alpha occurs in respiratory distress syndrome and is associated with poor outcome.
Pediatric research 1996;40(3):490-7.
1996: Murch S H; Costeloe K; Klein N J; Rees H; McIntosh N; Keeling J W; MacDonald T T
Mucosal tumor necrosis factor-alpha production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome.
Pediatric research 1996;40(3):484-9.
1996: Pender S L; Lionetti P; Murch S H; Wathan N; MacDonald T T
Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation.
Gut 1996;39(2):284-90.
1996: Fell J M; Walker-Smith J A; Spencer J; MacDonald T T
The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD).
Clinical and experimental immunology 1996;104(2):280-5.
1996: Thomas R; Schürmann G; Lionetti P; Pender S L; MacDonald T T
T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.
Gut 1996;38(2):190-5.
1995: Breese E J; Michie C A; Nicholls S W; Williams C B; Domizio P; Walker-Smith J A; MacDonald T T
The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease.
Alimentary pharmacology & therapeutics 1995;9(5):547-52.
1995: Penney L; Kilshaw P J; MacDonald T T
Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine.
Immunology 1995;86(2):212-8.
1995: Karttunen R; Karttunen T; Ekre H P; MacDonald T T
Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.
Gut 1995;36(3):341-5.
1995: Lionetti P; Murch S H; Taylor J; MacDonald T T
Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine.
Advances in experimental medicine and biology 1995;371A():493-6.
1995: Breese E; MacDonald T T
TNF alpha secreting cells in normal and diseased human intestine.
Advances in experimental medicine and biology 1995;371B():821-4.
1995: Taylor J; MacDonald T T; Spencer J
4D5.4, a monoclonal antibody which recognizes cells in inflamed human intestine.
Advances in experimental medicine and biology 1995;371B():1331-2.
1995: Murch S H; Braegger C P; Walker-Smith J A; MacDonald T T
Distribution and density of TNF immunoreactivity in chronic inflammatory bowel disease.
Advances in experimental medicine and biology 1995;371B():1327-30.
1994: Beattie R M; Schiffrin E J; Donnet-Hughes A; Huggett A C; Domizio P; MacDonald T T; Walker-Smith J A
Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease.
Alimentary pharmacology & therapeutics 1994;8(6):609-15.
1994: Karttunnen R; Breese E J; Walker-Smith J A; MacDonald T T
Decreased mucosal interleukin-4 (IL-4) production in gut inflammation.
Journal of clinical pathology 1994;47(11):1015-8.
1994: MacDonald T T
Development of mucosal immune function in man: potential for GI disease states.
Acta paediatrica Japonica; Overseas edition 1994;36(5):532-6.
1994: Nicholls S; Domizio P; Williams C B; Dawnay A; Braegger C P; MacDonald T T; Walker-Smith J A
Cyclosporin as initial treatment for Crohn's disease.
Archives of disease in childhood 1994;71(3):243-7.
1994: Latthe M; Terry L; MacDonald T T
High frequency of CD8 alpha alpha homodimer-bearing T cells in human fetal intestine.
European journal of immunology 1994;24(7):1703-5.
1994: Breese E J; Michie C A; Nicholls S W; Murch S H; Williams C B; Domizio P; Walker-Smith J A; MacDonald T T
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.
Gastroenterology 1994;106(6):1455-66.
1994: MacDonald T T; Spencer J; Murch S H; Choy M Y; Venugopal S; Bundy D A; Cooper E S
Immunoepidemiology of intestinal helminthic infections. 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(3):265-8.
1994: MacDonald T T; Spencer J
Ontogeny of the gut-associated lymphoid system in man.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1994;83(395):3-5.
1993: MacDonald T T; Murch S H; Nicholls S W; Breese E J
Diarrhoeal disease: current concepts and future challenges. Intestinal cytokines in inflammatory bowel disease and invasive diarrhoea.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1993;87 Suppl 3():23-6.
1993: Murch S H; Braegger C P; Walker-Smith J A; MacDonald T T
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
Gut 1993;34(12):1705-9.
1993: Nicholls S; Stephens S; Braegger C P; Walker-Smith J A; MacDonald T T
Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea.
Journal of clinical pathology 1993;46(8):757-60.
1993: Lionetti P; Breese E; Braegger C P; Murch S H; Taylor J; MacDonald T T
T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine.
Gastroenterology 1993;105(2):373-81.
1993: MacDonald T T
Aetiology of Crohn's disease.
Archives of disease in childhood 1993;68(5):623-5.
1993: Murch S H; MacDonald T T; Walker-Smith J A; Levin M; Lionetti P; Klein N J
Disruption of sulphated glycosaminoglycans in intestinal inflammation.
Lancet 1993;341(8847):711-4.
1993: Lionetti P; Spencer J; Breese E J; Murch S H; Taylor J; MacDonald T T
Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B.
European journal of immunology 1993;23(3):664-8.
1993: Breese E; Braegger C P; Corrigan C J; Walker-Smith J A; MacDonald T T
Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.
Immunology 1993;78(1):127-31.
1993: Braegger C P; Torresani T; Murch S H; Savage M O; Walker-Smith J A; MacDonald T T
Urinary growth hormone in growth-impaired children with chronic inflammatory bowel disease.
Journal of pediatric gastroenterology and nutrition 1993;16(1):49-52.
1992: MacDonald T T; Spencer J
Cell-mediated immune injury in the intestine.
Gastroenterology clinics of North America 1992;21(2):367-86.
1992: Murch S H; Braegger C P; Sessa W C; MacDonald T T
High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis.
Lancet 1992;339(8790):381-5.
1992: Braegger C P; Nicholls S; Murch S H; Stephens S; MacDonald T T
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation.
Lancet 1992;339(8785):89-91.
1992: Cooper E S; Whyte-Alleng C A; Finzi-Smith J S; MacDonald T T
Intestinal nematode infections in children: the pathophysiological price paid.
Parasitology 1992;104 Suppl():S91-103.
1992: MacDonald T T
Epithelial proliferation in response to gastrointestinal inflammation.
Annals of the New York Academy of Sciences 1992;664():202-9.
1991: Cooper E S; Spencer J; Whyte-Alleng C A; Cromwell O; Whitney P; Venugopal S; Bundy D A; Haynes B; MacDonald T T
Immediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery.
Lancet 1991;338(8775):1104-7.
1991: Murch S H; Lamkin V A; Savage M O; Walker-Smith J A; MacDonald T T
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.
Gut 1991;32(8):913-7.
1991: MacDonald T T; Choy M Y; Spencer J; Richman P I; Diss T; Hanchard B; Venugopal S; Bundy D A; Cooper E S
Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome.
Journal of clinical pathology 1991;44(3):194-9.
1990: Viney J L; MacDonald T T
Selective death of T cell receptor gamma/delta+ intraepithelial lymphocytes by apoptosis.
European journal of immunology 1990;20(12):2809-12.
1990: Choy M Y; Walker-Smith J A; Williams C B; MacDonald T T
Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.
Gut 1990;31(12):1365-70.
1990: Braegger C P; Corrigan C J; MacDonald T T
Finger clubbing and tumour necrosis factor alpha.
Lancet 1990;336(8717):759-60.
1990: Viney J; MacDonald T T; Spencer J
Gamma/delta T cells in the gut epithelium.
Gut 1990;31(8):841-4.
1990: MacDonald T T; Hutchings P; Choy M Y; Murch S; Cooke A
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.
Clinical and experimental immunology 1990;81(2):301-5.
1990: Viney J L; Kilshaw P J; MacDonald T T
Cytotoxic alpha/beta+ and gamma/delta+ T cells in murine intestinal epithelium.
European journal of immunology 1990;20(7):1623-6.
1990: Ferreira R C; Forsyth L E; Richman P I; Wells C; Spencer J; MacDonald T T
Changes in the rate of crypt epithelial cell proliferation and mucosal morphology induced by a T-cell-mediated response in human small intestine.
Gastroenterology 1990;98(5 Pt 1):1255-63.
1990: Cooper E S; Bundy D A; MacDonald T T; Golden M H
Growth suppression in the Trichuris dysentery syndrome.
European journal of clinical nutrition 1990;44(4):285-91.
1990: MacDonald T T; Horton M A; Choy M Y; Richman P I
Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.
Journal of clinical pathology 1990;43(4):313-5.
1990: Choy M Y; Richman P I; Horton M A; MacDonald T T
Expression of the VLA family of integrins in human intestine.
The Journal of pathology 1990;160(1):35-40.
1990: MacDonald T T; Spencer J
Ontogeny of the mucosal immune response.
Springer seminars in immunopathology 1990;12(2-3):129-37.
1989: Viney J L; MacDonald T T; Kilshaw P J
Alpha beta T cell receptor expression in rat intestinal epithelium.
Immunology letters 1989;23(1):49-53.
1989: Viney J L; MacDonald T T; Kilshaw P J
T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice.
Immunology 1989;66(4):583-7.
1988: Monk T; Spencer J; Cerf-Bensussan N; MacDonald T T
Stimulation of mucosal T cells in situ with anti-CD3 antibody: location of the activated T cells and their distribution within the mucosal micro-environment.
Clinical and experimental immunology 1988;74(2):216-22.
1988: MacDonald T T; Weinel A; Spencer J
HLA-DR expression in human fetal intestinal epithelium.
Gut 1988;29(10):1342-8.
1988: MacDonald T T; Spencer J
Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.
The Journal of experimental medicine 1988;167(4):1341-9.
1987: MacDonald T T; Spencer J; Viney J L; Williams C B; Walker-Smith J A
Selective biopsy of human Peyer's patches during ileal endoscopy.
Gastroenterology 1987;93(6):1356-62.
1987: MacDonald T T; Dillon S B
Limiting dilution analysis of functional T cells in the gut mucosa.
Advances in experimental medicine and biology 1987;216A():131-41.

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