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Thomas MacDonald

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Eleonora Franzè; Thomas T MacDonald; Claudia Antenucci; Marta Ascolani; Flavio Caprioli; Roberta Caruso; Maria Laura Cupi; Francesco Pallone; Alessandra Ruffa; Massimiliano Sarra; Silvia Sedda; Carmine Stolfi; Giovanni Monteleone
High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases.
Paolo Biancheri; Gino R Corazza; Antonio Di Sabatino; Thomas T MacDonald
Proteases and the gut barrier.
Ivan Monteleone; Francesco Pallone; Angelamaria Rizzo; Massimiliano Sarra; Francesca Zorzi; Viviana Casagrande; Michele Cavalera; Massimo Federici; Eleonora Franzè; Renato Lauro; Thomas T MacDonald; Giovanni Monteleone
Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.

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2013: Eleonora Franzè; Thomas T MacDonald; Claudia Antenucci; Marta Ascolani; Flavio Caprioli; Roberta Caruso; Maria Laura Cupi; Francesco Pallone; Alessandra Ruffa; Massimiliano Sarra; Silvia Sedda; Carmine Stolfi; Giovanni Monteleone
High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases.
Inflammatory bowel diseases 2013;19(3):501-11.
2013: Paolo Biancheri; Gino R Corazza; Antonio Di Sabatino; Thomas T MacDonald
Proteases and the gut barrier.
Cell and tissue research 2013;351(2):269-80.
2012: Ivan Monteleone; Francesco Pallone; Angelamaria Rizzo; Massimiliano Sarra; Francesca Zorzi; Viviana Casagrande; Michele Cavalera; Massimo Federici; Eleonora Franzè; Renato Lauro; Thomas T MacDonald; Giovanni Monteleone
Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.
Gastroenterology 2012;143(5):1277-87.e1-4.
2012: Thomas T MacDonald; Paolo Biancheri; Massimiliano Sarra; Giovanni Monteleone
What's the next best cytokine target in IBD?
Inflammatory bowel diseases 2012;18(11):2180-9.
2012: Thomas T MacDonald; Massimo Fantini; Anna Vossenkaemper; Giovanni Monteleone
Reprogramming the immune system in IBD.
Digestive diseases (Basel, Switzerland) 2012;30(4):392-5.
2011: Carmine Stolfi; Ivan Monteleone; Francesco Pallone; Angelamaria Rizzo; Angela Rotondi; Massimiliano Sarra; pierpaolo sileri; Flavio Caprioli; Roberta Caruso; Massimo C Fantini; Stefano Ferrero; Luana Franceschilli; Eleonora Franzè; Thomas T MacDonald; Giovanni Monteleone
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer.
The Journal of experimental medicine 2011;208(11):2279-90.
2011: Thomas T MacDonald; Iona Bell; Giovanni Monteleone
The opposing roles of IL-21 and TGFβ1 in chronic inflammatory bowel disease.
Biochemical Society transactions 2011;39(4):1061-6.
2011: Thomas T MacDonald
New cytokine targets in inflammatory bowel disease.
Gastroenterology & hepatology 2011;7(7):474-6.
2011: Ivan Monteleone; Francesco Pallone; Angelamaria Rizzo; Massimiliano Sarra; Giuseppe Sica; pierpaolo sileri; Livia Biancone; Thomas T MacDonald; Giovanni Monteleone
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract.
Gastroenterology 2011;141(1):237-48, 248.e1.
2011: Massimiliano Sarra; Roberta Caruso; Maria Laura Cupi; Ivan Monteleone; Carmine Stolfi; Elena Campione; Laura Diluvio; Annamaria Mazzotta; Elisabetta Botti; Sergio Chimenti; Antonio Costanzo; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-γ-dependent epidermal hyperplasia.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5435-42.
2011: Laura Rovedatti; Antonio Di Sabatino; Charles H Knowles; Neel Sengupta; Paolo Biancheri; Gino R Corazza; Thomas T MacDonald
Fibroblast activation protein expression in Crohn's disease strictures.
Inflammatory bowel diseases 2011;17(5):1251-3.
2011: Antonio Di Sabatino; Laura Rovedatti; Stefania Vetrano; Francesca Vidali; Paolo Biancheri; Maria Rescigno; Silvio Danese; Thomas T MacDonald; Gino R Corazza
Involvement of CD40-CD40 ligand in uncomplicated and refractory celiac disease.
The American journal of gastroenterology 2011;106(3):519-27.
2011: Anna Vossenkämper; Thomas T MacDonald; Olivier Marchès
Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system.
Journal of inflammation (London, England) 2011;8():11.
2010: Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Interleukin-25: a two-edged sword in the control of immune-inflammatory responses.
Cytokine & growth factor reviews 2010;21(6):471-5.
2010: Thomas T MacDonald
Inside the microbial and immune labyrinth: totally gutted.
Nature medicine 2010;16(11):1194-5.
2010: G Docena; L Rovedatti; Laurens Kruidenier; A Fanning; N A B Leakey; C H Knowles; K Lee; F Shanahan; K Nally; peter g mclean; Antonio Di Sabatino; Thomas T MacDonald
Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease.
Clinical and experimental immunology 2010;162(1):108-15.
2010: Thomas T MacDonald; Iona Bell
Probiotics and the immune response to vaccines.
The Proceedings of the Nutrition Society 2010;69(3):442-6.
2010: Massimiliano Sarra; Ivan Monteleone; Carmine Stolfi; Massimo C Fantini; pierpaolo sileri; Giuseppe Sica; Roberto Tersigni; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases.
Inflammatory bowel diseases 2010;16(8):1332-9.
2010: Thomas T MacDonald
Cytokine regulation of intestinal epithelial cell proliferation.
Expert review of clinical immunology 2010;6(4):531-5.
2010: Massimiliano Sarra; Francesco Pallone; Thomas T MacDonald; Giovanni Monteleone
Targeting interleukin-21 in immune-mediated pathologies.
Current drug targets 2010;11(5):645-9.
2010: Ivan Monteleone; Massimiliano Sarra; Giovanna Del Vecchio Blanco; Omero Alessandro Paoluzi; Eleonora Franzè; Daniele Fina; Alessia Fabrizi; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
Characterization of IL-17A-producing cells in celiac disease mucosa.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):2211-8.
2010: Carmine Stolfi; Massimiliano Sarra; Roberta Caruso; Massimo C Fantini; Daniele Fina; Roberto Pellegrini; Giampiero Palmieri; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine.
Gastroenterology 2010;138(1):221-30.
2009: John N Gordon; J D Prothero; C A Thornton; Karen M Pickard; Antonio Di Sabatino; Patrick M Goggin; Sylvia L F Pender; Thomas T MacDonald
CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease.
Journal of Crohn's & colitis 2009;3(3):175-82.
2009: Antonio Di Sabatino; Laura Rovedatti; Rejbinder Kaur; Jonathan P Spencer; Jon T Brown; Valerie D Morisset; Paolo Biancheri; Nicholas A B Leakey; Jonathan Wilde; Laurie Scott; Gino R Corazza; Kevin Lee; Neel Sengupta; Charles H Knowles; Martin J Gunthorpe; peter g mclean; Thomas T MacDonald; Laurens Kruidenier
Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3454-62.
2009: Antonio Di Sabatino; Ulpu Saarialho-Kere; Mark G Buckley; John N Gordon; Paolo Biancheri; Laura Rovedatti; Gino R Corazza; Thomas T MacDonald; Sylvia L F Pender
Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab.
European journal of gastroenterology & hepatology 2009;21(9):1049-55.
2009: Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Interleukin-21 as a new therapeutic target for immune-mediated diseases.
Trends in pharmacological sciences 2009;30(8):441-7.
2009: Thomas T MacDonald; A Vossenkamper; Anna Voessenkamper; Antonio Di Sabatino
Antigen presenting cells and T cell interactions in the gastrointestinal tract.
Molecular nutrition & food research 2009;53(8):947-51.
2009: Roberta Caruso; Massimiliano Sarra; Carmine Stolfi; Angelamaria Rizzo; Daniele Fina; Massimo C Fantini; Francesco Pallone; Thomas T MacDonald; Giovanni Monteleone
Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut.
Gastroenterology 2009;136(7):2270-9.
2009: Antonio Di Sabatino; C L Jackson; Karen M Pickard; M Buckley; L Rovedatti; N A B Leakey; Lucia Picariello; P Cazzola; Giovanni Monteleone; Francesco Tonelli; G R Corazza; Thomas T MacDonald; Sylvia L F Pender
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures.
Gut 2009;58(6):777-89.
2009: Antonio Di Sabatino; Laura Rovedatti; Manuela M Rosado; Rita Carsetti; Gino R Corazza; Thomas T MacDonald
Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood.
Human pathology 2009;40(5):699-704.
2009: Roberta Caruso; Carmine Stolfi; Massimiliano Sarra; Angelamaria Rizzo; Massimo C Fantini; Francesco Pallone; Thomas T MacDonald; Giovanni Monteleone
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Blood 2009;113(15):3512-9.
2009: Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Interleukin-21 (IL-21)-mediated pathways in T cell-mediated disease.
Cytokine & growth factor reviews 2009;20(2):185-91.
2009: Massimo C Fantini; Angelamaria Rizzo; Daniele Fina; Roberta Caruso; Massimiliano Sarra; Carmine Stolfi; Christoph Becker; Thomas T MacDonald; Francesco Pallone; Markus F Neurath; Giovanni Monteleone
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.
Gastroenterology 2009;136(4):1308-16, e1-3.
2009: S-L Chuang; Peter J Hayes; E Ogundipe; M Haddad; Thomas T MacDonald; John M Fell
Cow's milk protein-specific T-helper type I/II cytokine responses in infants with necrotizing enterocolitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2009;20(1):45-52.
2008: Cordula Hemrajani; Olivier Marches; Siouxsie Wiles; Francis Girard; Alison Dennis; Francis Dziva; Angus Best; Alan D Phillips; Cedric N Berger; Aurelie Mousnier; Valerie F Crepin; Laurens Kruidenier; Martin J Woodward; Mark P Stevens; Roberto M La Ragione; Thomas T MacDonald; Gad Frankel
Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.
Infection and immunity 2008;76(11):4804-13.
2008: Alison Dennis; Takahiro Kudo; Laurens Kruidenier; Francis Girard; Valerie F Crepin; Thomas T MacDonald; Gad Frankel; Siouxsie Wiles
The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.
Infection and immunity 2008;76(11):4978-88.
2008: Daniele Fina; M Sarra; Roberta Caruso; Giovanna Del Vecchio Blanco; Francesco Pallone; Thomas T MacDonald; Giovanni Monteleone
Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease.
Gut 2008;57(7):887-92.
2008: Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses.
Trends in immunology 2008;29(6):290-4.
2008: Antonio Di Sabatino; Karen M Pickard; David S Rampton; L Kruidenier; L Rovedatti; N A B Leakey; G R Corazza; Giovanni Monteleone; Thomas T MacDonald
Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa.
Gut 2008;57(5):605-12.
2008: Daniele Fina; Massimiliano Sarra; Massimo C Fantini; Angelamaria Rizzo; Roberta Caruso; Flavio Caprioli; Carmine Stolfi; Iris Cardolini; Marta Dottori; Monica Boirivant; Francesco Pallone; Thomas T MacDonald; Giovanni Monteleone
Regulation of gut inflammation and th17 cell response by interleukin-21.
Gastroenterology 2008;134(4):1038-48.
2008: Flavio Caprioli; Massimiliano Sarra; Roberta Caruso; Carmine Stolfi; Daniele Fina; Giuseppe Sica; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
Autocrine regulation of IL-21 production in human T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1800-7.
2008: Roberta Caruso; Daniele Fina; Omero Alessandro Paoluzi; Giovanna Del Vecchio Blanco; Carmine Stolfi; Angelamaria Rizzo; Flavio Caprioli; Massimiliano Sarra; Fabio Andrei; Massimo C Fantini; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa.
European journal of immunology 2008;38(2):470-8.
2008: John N Gordon; Karen M Pickard; Antonio Di Sabatino; Joanna D Prothero; Sylvia L F Pender; Patrick M Goggin; Thomas T MacDonald
Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease.
Inflammatory bowel diseases 2008;14(2):195-203.
2007: Massimo C Fantini; Agelamaria Rizzo; Daniele Fina; Roberta Caruso; Christoph Becker; Markus F Neurath; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.
European journal of immunology 2007;37(11):3155-63.
2007: Massimo C Fantini; Giovanni Monteleone; Thomas T MacDonald
New players in the cytokine orchestra of inflammatory bowel disease.
Inflammatory bowel diseases 2007;13(11):1419-23.
2007: Antonio Di Sabatino; Karen M Pickard; John N Gordon; Virginia M Salvati; Giuseppe Mazzarella; R Mark Beattie; Anna Vossenkaemper; Laura Rovedatti; Nicholas A B Leakey; Nicholas M Croft; Riccardo Troncone; Gino R Corazza; Andrew J Stagg; Giovanni Monteleone; Thomas T MacDonald
Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease.
Gastroenterology 2007;133(4):1175-87.
2007: Antonio Di Sabatino; Sylvia L F Pender; Claire L Jackson; Joanna D Prothero; John N Gordon; Lucia Picariello; Laura Rovedatti; Guillermo Docena; Giovanni Monteleone; David S Rampton; Francesco Tonelli; Gino R Corazza; Thomas T MacDonald
Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies.
Gastroenterology 2007;133(1):137-49.
2007: Roberta Caruso; Daniele Fina; Ilaria Peluso; Massimo C Fantini; Claudio Tosti; Giovanna Del Vecchio Blanco; Omero Alessandro Paoluzi; Flavio Caprioli; Fabio Andrei; Carmine Stolfi; Marco Romano; Vittorio Ricci; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5957-65.
2007: Ilaria Peluso; Massimo C Fantini; Daniele Fina; Roberta Caruso; Monica Boirivant; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):732-9.
2007: Roberta Caruso; Daniele Fina; Ilaria Peluso; Carmine Stolfi; Massimo C Fantini; Valentina Gioia; Flavio Caprioli; Giovanna Del Vecchio Blanco; Omero Alessandro Paoluzi; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.
Gastroenterology 2007;132(1):166-75.
2006: Monica Boirivant; Francesco Pallone; Claudia Di Giacinto; Daniele Fina; Ivan Monteleone; Mariarosaria Marinaro; Roberta Caruso; Alfredo Colantoni; Giampiero Palmieri; Massimo Sanchez; Warren Strober; Thomas T MacDonald; Giovanni Monteleone
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.
Gastroenterology 2006;131(6):1786-98.
2006: Giovanni Monteleone; Roberta Caruso; Daniele Fina; Ilaria Peluso; Valentina Gioia; Carmine Stolfi; Massimo C Fantini; Flavio Caprioli; Roberto Tersigni; Luciano Alessandroni; Thomas T MacDonald; Francesco Pallone
Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.
Gut 2006;55(12):1774-80.
2006: Siouxsie Wiles; Karen M Pickard; Katian Peng; Thomas T MacDonald; Gad Frankel
In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium.
Infection and immunity 2006;74(9):5391-6.
2006: Sylvia L F Pender; C K F Li; A Di Sabatino; A D I Sabatino; Thomas T MacDonald; M G Buckley
Role of macrophage metalloelastase in gut inflammation.
Annals of the New York Academy of Sciences 2006;1072():386-8.
2006: Roberta Caruso; Francesco Pallone; Daniele Fina; Valentina Gioia; Ilaria Peluso; Flavio Caprioli; Carmine Stolfi; Alessandra Perfetti; Luigi Giusto Spagnoli; Giampiero Palmieri; Thomas T MacDonald; Giovanni Monteleone
Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation.
The American journal of pathology 2006;169(1):268-78.
2006: Thomas T MacDonald; Giovanni Monteleone
Overview of role of the immune system in the pathogenesis of inflammatory bowel disease.
Advances in experimental medicine and biology 2006;579():98-107.
2005: Rosanna Mundy; Thomas T MacDonald; Gordon Dougan; Gad Frankel; Siouxsie Wiles
Citrobacter rodentium of mice and man.
Cellular microbiology 2005;7(12):1697-706.
2005: Giovanni Monteleone; Giovanna Del Vecchio Blanco; Ivan Monteleone; Daniele Fina; Roberta Caruso; Valentina Gioia; Sabrina Ballerini; Giorgio Federici; Sergio Bernardini; Francesco Pallone; Thomas T MacDonald
Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.
Gastroenterology 2005;129(5):1420-9.
2005: John N Gordon; Thomas T MacDonald
Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease.
Gut 2005;54(9):1213-5.
2005: Thomas T MacDonald; John N Gordon
Bacterial regulation of intestinal immune responses.
Gastroenterology clinics of North America 2005;34(3):401-12, vii-viii.
2005: Shyam Prasad; Roberto Mingrino; Katri Kaukinen; Katherine L Hayes; Robert M Powell; Thomas T MacDonald; Jane E Collins
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Laboratory investigation; a journal of technical methods and pathology 2005;85(9):1139-62.
2005: Sylvia L F Pender; Victoria Chance; C V Whiting; M Buckley; M Edwards; R Pettipher; Thomas T MacDonald
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.
Gut 2005;54(8):1114-20.
2005: Thomas T MacDonald; Antonio Di Sabatino; Antonio DiSabatino; John N Gordon
Immunopathogenesis of Crohn's disease.
JPEN. Journal of parenteral and enteral nutrition 2005;29(4 Suppl):S118-24; discussion S124-5, S184-8.
2005: John N Gordon; Antonio Di Sabatino; Thomas T MacDonald
The pathophysiologic rationale for biological therapies in inflammatory bowel disease.
Current opinion in gastroenterology 2005;21(4):431-7.
2005: Mairi Brittan; Victoria Chance; George Elia; Richard Poulsom; Stuart McDonald; Thomas T MacDonald; Nicholas A Wright
A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.
Gastroenterology 2005;128(7):1984-95.
2005: Ute Gunther; Judith Holloway; John N Gordon; John G Gordon; Andrea Knight; Victoria Chance; Neil A Hanley; David I Wilson; Ruth French; Jo Spencer; Howard Steer; Graham Anderson; Thomas T MacDonald
Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5414-22.
2005: Thomas T MacDonald; Giovanni Monteleone
Immunity, inflammation, and allergy in the gut.
Science (New York, N.Y.) 2005;307(5717):1920-5.
2005: Giovanni Monteleone; Ivan Monteleone; Daniele Fina; Piero Vavassori; Giovanna Del Vecchio Blanco; Roberta Caruso; Roberto Tersigni; Luciano Alessandroni; Livia Biancone; Gian Carlo Naccari; Thomas T MacDonald; Francesco Pallone
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease.
Gastroenterology 2005;128(3):687-94.
2004: Sylvia L F Pender; Thomas T MacDonald
Matrix metalloproteinases and the gut - new roles for old enzymes.
Current opinion in pharmacology 2004;4(6):546-50.
2004: Mikko T Salmela; Sylvia L F Pender; Marja-Liisa Karjalainen-Lindsberg; Pauli Puolakkainen; Thomas T MacDonald; Ulpu Saarialho-Kere
Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing.
Scandinavian journal of gastroenterology 2004;39(11):1095-104.
2004: Chris K F Li; Sylvia L F Pender; Karen M Pickard; Victoria Chance; Judith Holloway; Alan Huett; Nathalie S Gonçalves; John S Mudgett; Gordon Dougan; Gad Frankel; Thomas T MacDonald
Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5171-9.
2004: Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Smad7 in TGF-beta-mediated negative regulation of gut inflammation.
Trends in immunology 2004;25(10):513-7.
2004: Ivan Monteleone; Giovanni Monteleone; Giovanna Del Vecchio Blanco; Piero Vavassori; Salvatore Cucchiara; Thomas T MacDonald; Francesco Pallone
Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa.
Gut 2004;53(8):1090-5.
2004: Karen M Pickard; A Ronald Bremner; John N Gordon; Thomas T MacDonald
Microbial-gut interactions in health and disease. Immune responses.
Best practice & research. Clinical gastroenterology 2004;18(2):271-85.
2004: Giovanni Monteleone; Giovanna Del Vecchio Blanco; Giampiero Palmieri; Piero Vavassori; Ivan Monteleone; Alfredo Colantoni; Serena Battista; Luigi Giusto Spagnoli; Marco Romano; Melissa Borrelli; Thomas T MacDonald; Francesco Pallone
Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection.
Gastroenterology 2004;126(3):674-82.
2004: Giovanni Monteleone; Jelena Mann; Ivan Monteleone; Piero Vavassori; Ronald Bremner; Massimo C Fantini; Giovanna Del Vecchio Blanco; Roberto Tersigni; Luciano Alessandroni; Derek Mann; Francesco Pallone; Thomas T MacDonald
A failure of transforming growth factor-beta1 negative regulation maintains sustained NF-kappaB activation in gut inflammation.
The Journal of biological chemistry 2004;279(6):3925-32.
2003: John N Gordon; Thomas T MacDonald
Biological therapy in Crohn's disease.
Hospital medicine (London, England : 1998) 2003;64(12):708-12.
2003: Cameron P Simmons; Simon Clare; Marjan Ghaem-Maghami; Tania K Uren; Joanna Rankin; Alan Huett; Robert Goldin; David J M Lewis; Thomas T MacDonald; Richard A Strugnell; Gad Frankel; Gordon Dougan
Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium.
Infection and immunity 2003;71(9):5077-86.
2003: Virginia M Salvati; Thomas T MacDonald; Giovanna Del Vecchio Blanco; Giuseppe Mazzarella; Ivan Monteleone; Piero Vavassori; Salvatore Auricchio; Francesco Pallone; Riccardo Troncone; Giovanni Monteleone
Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease.
Pediatric research 2003;54(3):312-8.
2003: Sylvia L F Pender; Christian P Braegger; Ute Gunther; Giovanni Monteleone; Martin Meuli; Detlef Schuppan; Thomas T MacDonald
Matrix metalloproteinases in necrotising enterocolitis.
Pediatric research 2003;54(2):160-4.
2003: Giuseppe Mazzarella; Thomas T MacDonald; Virginia M Salvati; Peter Mulligan; Luigi Pasquale; Rosita Stefanile; Paolo Lionetti; Salvatore Auricchio; Francesco Pallone; Riccardo Troncone; Giovanni Monteleone
Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions.
The American journal of pathology 2003;162(6):1845-55.
2003: Thomas T MacDonald
The mucosal immune system.
Parasite immunology 2003;25(5):235-46.
2003: Nathalie S Gonçalves; Christine Hale; Gordon Dougan; Gad Frankel; Thomas T MacDonald
Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences.
Infection and immunity 2003;71(5):2960-5.
2003: Thomas T MacDonald; Gad Frankel; Gordon Dougan; Nathalie S Goncalves; Cameron Simmons
Host defences to Citrobacter rodentium.
International journal of medical microbiology : IJMM 2003;293(1):87-93.
2003: Giovanni Monteleone; Judith Holloway; Virginia M Salvati; Sylvia L F Pender; Peter D Fairclough; Nicholas M Croft; Thomas T MacDonald
Activated STAT4 and a functional role for IL-12 in human Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):300-7.
2002: Mikko T Salmela; Thomas T MacDonald; D Black; B Irvine; T Zhuma; Ulpu Saarialho-Kere; Sylvia L F Pender
Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation.
Gut 2002;51(4):540-7.
2002: Thomas T MacDonald
Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers.
Gut 2002;51(3):311-2.
2002: Cameron P Simmons; Nathalie S Goncalves; Marjan Ghaem-Maghami; Mona Bajaj-Elliott; Simon Clare; Bianca C Neves; Gad Frankel; Gordon Dougan; Thomas T MacDonald
Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1804-12.
2002: Virginia M Salvati; Thomas T MacDonald; M Bajaj-Elliott; Melissa Borrelli; Annamaria Staiano; Salvatore Auricchio; Riccardo Troncone; Giovanni Monteleone
Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.
Gut 2002;50(2):186-90.
2001: N S Gonçalves; Marjan Ghaem-Maghami; G Monteleone; Gad Frankel; Gordon Dougan; David J M Lewis; Cameron P Simmons; Thomas T MacDonald
Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis.
Infection and immunity 2001;69(11):6651-9.
2001: Giovanni Monteleone; A Kumberova; Nicholas M Croft; C McKenzie; H W Steer; Thomas T MacDonald
Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease.
The Journal of clinical investigation 2001;108(4):601-9.
2001: Catherine A Jones; G H S Vance; Lynsey L Power; Sylvia L F Pender; Thomas T MacDonald; John O Warner
Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming.
The Journal of allergy and clinical immunology 2001;108(2):235-41.
2001: Giovanni Monteleone; Sylvia L F Pender; NC Wathen; Thomas T MacDonald
Interferon-alpha drives T cell-mediated immunopathology in the intestine.
European journal of immunology 2001;31(8):2247-55.
2001: Virginia M Salvati; M Bajaj-Elliott; R Poulsom; Giuseppe Mazzarella; Knut E A Lundin; EM Nilsen; Riccardo Troncone; Thomas T MacDonald
Keratinocyte growth factor and coeliac disease.
Gut 2001;49(2):176-81.
2001: Thomas T MacDonald; Giovanni Monteleone
IL-12 and Th1 immune responses in human Peyer's patches.
Trends in immunology 2001;22(5):244-7.
2001: Thomas T MacDonald
The worm turns on Helicobacter pylori.
Gut 2001;48(1):10-1.
2000: Sylvia L F Pender; Mikko T Salmela; Giovanni Monteleone; D Schnapp; C McKenzie; J Spencer; S Fong; Ulpu Saarialho-Kere; Thomas T MacDonald
Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype.
The American journal of pathology 2000;157(6):1955-62.
2000: Sylvia L F Pender; JJ Quinn; Ian R Sanderson; Thomas T MacDonald
Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(5):G918-24.
2000: S Nagata; C McKenzie; Sylvia L F Pender; M Bajaj-Elliott; Peter D Fairclough; JA Walker-Smith; Giovanni Monteleone; Thomas T MacDonald
Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5315-21.
2000: Elizabeth L Hartland; Veronika Huter; L M Higgins; Nathalie S Goncalves; Gordon Dougan; Alan D Phillips; Thomas T MacDonald; Gad Frankel
Expression of intimin gamma from enterohemorrhagic Escherichia coli in Citrobacter rodentium.
Infection and immunity 2000;68(8):4637-46.
2000: Robert Heuschkel; Thomas T MacDonald; Giovanni Monteleone; M Bajaj-Elliott; J A Smith; Sylvia L F Pender
Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease.
Gut 2000;47(1):57-62.
2000: Thomas T MacDonald; S Pettersson
Bacterial regulation of intestinal immune responses.
Inflammatory bowel diseases 2000;6(2):116-22.
2000: John M Fell; Morine Paintin; Franck Arnaud-Battandier; R Mark Beattie; A Hollis; P Kitching; A Donnet-Hughes; Thomas T MacDonald; John Walker-Smith
Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease.
Alimentary pharmacology & therapeutics 2000;14(3):281-9.
1999: Giovanni Monteleone; Thomas T MacDonald; NC Wathen; F Pallone; Sylvia L F Pender
Enhancing Lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury.
Gastroenterology 1999;117(5):1069-77.
1999: Thomas T MacDonald; M Bajaj-Elliott; Sylvia L F Pender
T cells orchestrate intestinal mucosal shape and integrity.
Immunology today 1999;20(11):505-10.
1999: LM Higgins; G Frankel; I Connerton; N S Gonçalves; G Dougan; Thomas T MacDonald
Role of bacterial intimin in colonic hyperplasia and inflammation.
Science (New York, N.Y.) 1999;285(5427):588-91.
1999: Sylvia L F Pender; C McKenzie; A Shaida; Thomas T MacDonald
Regulation of matrix metalloproteinases in human intestinal mucosa.
Annals of the New York Academy of Sciences 1999;878():581-2.
1999: LM Higgins; G Frankel; G Douce; G Dougan; Thomas T MacDonald
Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease.
Infection and immunity 1999;67(6):3031-9.
1999: John M Fell; Morine Paintin; A Donnet-Hughes; Franck Arnaud-Battandier; Thomas T MacDonald; John Walker-Smith
Remission induced by a new specific oral polymeric diet in children with Crohn's disease.
Nestlé Nutrition workshop series. Clinical & performance programme 1999;2():187-96; discussion 196-8.
1999: Thomas T MacDonald
Effector and regulatory lymphoid cells and cytokines in mucosal sites.
Current topics in microbiology and immunology 1999;236():113-35.
1999: LM Higgins; Stuart McDonald; N Whittle; N Crockett; J G Shields; Thomas T MacDonald
Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):486-93.
1998: D Howie; J Spencer; D DeLord; C Pitzalis; NC Wathen; A Dogan; A Akbar; Thomas T MacDonald
Extrathymic T cell differentiation in the human intestine early in life.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5862-72.
1998: Thomas T MacDonald
Depletion of the enteric nervous system by gene targeting results in haemorrhagic necrosis of the ileum.
Gut 1998;43(6):742-3.
1998: Sylvia L F Pender; Thomas T MacDonald
Regulation of matrix metalloproteinase production in human fetal intestinal mesenchymal cells by cytokines and the bacterial superantigen Staphylococcus aureus enterotoxin B.
Annals of the New York Academy of Sciences 1998;859():188-91.
1998: M Bajaj-Elliott; Sylvia L F Pender; R Poulsom; Thomas T MacDonald
Upregulation of keratinocyte growth factor during T-cell immunity in the gut mucosa.
Annals of the New York Academy of Sciences 1998;859():184-7.
1998: M Bajaj-Elliott; R Poulsom; Sylvia L F Pender; NC Wathen; Thomas T MacDonald
Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.
The Journal of clinical investigation 1998;102(8):1473-80.
1998: Sylvia L F Pender; E J Breese; U Günther; D Howie; NC Wathen; Detlef Schuppan; Thomas T MacDonald
Suppression of T cell-mediated injury in human gut by interleukin 10: role of matrix metalloproteinases.
Gastroenterology 1998;115(3):573-83.
1998: AC Hauer; M Bajaj-Elliott; C B Williams; JA Walker-Smith; Thomas T MacDonald
An analysis of interferon gamma, IL-4, IL-5 and IL-10 production by ELISPOT and quantitative reverse transcriptase-PCR in human Peyer's patches.
Cytokine 1998;10(8):627-34.
1998: Thomas T MacDonald; Sylvia L F Pender
Proteolytic enzymes in inflammatory bowel disease.
Inflammatory bowel diseases 1998;4(2):157-64.
1998: Sylvia L F Pender; J M Fell; S M Chamow; A Ashkenazi; Thomas T MacDonald
A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):4098-103.
1998: Thomas T MacDonald
Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease.
Gut 1998;42(4):460-1.
1997: AC Hauer; T M Finn; Thomas T MacDonald; J Spencer; P G Isaacson
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
Journal of clinical pathology 1997;50(11):957-9.
1997: Thomas T MacDonald
Cytokine gene deleted mice in the study of gastrointestinal inflammation.
European journal of gastroenterology & hepatology 1997;9(11):1051-5.
1997: M Bajaj-Elliott; E Breese; R Poulsom; Peter D Fairclough; Thomas T MacDonald
Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.
The American journal of pathology 1997;151(5):1469-76.
1997: AC Hauer; E J Breese; JA Walker-Smith; Thomas T MacDonald
The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity.
Pediatric research 1997;42(5):629-38.
1997: Stuart McDonald; MJ Palmen; EP van Rees; Thomas T MacDonald
Characterization of the mucosal cell-mediated immune response in IL-2 knockout mice before and after the onset of colitis.
Immunology 1997;91(1):73-80.
1997: Thomas T MacDonald
Oxpentifylline, tumour necrosis factor-alpha and Crohn's disease.
Gut 1997;40(4):559.
1997: Sylvia L F Pender; S P Tickle; A J Docherty; D Howie; NC Wathen; Thomas T MacDonald
A major role for matrix metalloproteinases in T cell injury in the gut.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1582-90.
1996: I Penney; P J Kilshaw; Thomas T MacDonald
Increased division of alpha beta TCR+ and gamma delta TCR+ intestinal intraepithelial lymphocytes after oral administration of cholera toxin.
Immunology 1996;89(1):54-8.
1996: Simon H Murch; Kate Costeloe; N J Klein; Thomas T MacDonald
Early production of macrophage inflammatory protein-1 alpha occurs in respiratory distress syndrome and is associated with poor outcome.
Pediatric research 1996;40(3):490-7.
1996: Simon H Murch; Kate Costeloe; N J Klein; H Rees; N McIntosh; J W Keeling; Thomas T MacDonald
Mucosal tumor necrosis factor-alpha production and extensive disruption of sulfated glycosaminoglycans begin within hours of birth in neonatal respiratory distress syndrome.
Pediatric research 1996;40(3):484-9.
1996: S L Pender; P Lionetti; Simon H Murch; N Wathan; Thomas T MacDonald
Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation.
Gut 1996;39(2):284-90.
1996: J M Fell; John Walker-Smith; J Spencer; Thomas T MacDonald
The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD).
Clinical and experimental immunology 1996;104(2):280-5.
1996: R Thomas; G Schürmann; P Lionetti; S L Pender; Thomas T MacDonald
T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.
Gut 1996;38(2):190-5.
1995: E J Breese; C A Michie; S W Nicholls; C B Williams; P Domizio; John Walker-Smith; Thomas T MacDonald
The effect of treatment on lymphokine-secreting cells in the intestinal mucosa of children with Crohn's disease.
Alimentary pharmacology & therapeutics 1995;9(5):547-52.
1995: L Penney; P J Kilshaw; Thomas T MacDonald
Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine.
Immunology 1995;86(2):212-8.
1995: R Karttunen; Tuomo J Karttunen; H P Ekre; Thomas T MacDonald
Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.
Gut 1995;36(3):341-5.
1995: P Lionetti; Simon H Murch; J Taylor; Thomas T MacDonald
Mucosal adaptation and destruction in response to lamina propria T cell activation in explants of human fetal intestine.
Advances in experimental medicine and biology 1995;371A():493-6.
1995: E Breese; Thomas T MacDonald
TNF alpha secreting cells in normal and diseased human intestine.
Advances in experimental medicine and biology 1995;371B():821-4.
1995: J Taylor; Thomas T MacDonald; J Spencer
4D5.4, a monoclonal antibody which recognizes cells in inflamed human intestine.
Advances in experimental medicine and biology 1995;371B():1331-2.
1995: Simon H Murch; C P Braegger; John Walker-Smith; Thomas T MacDonald
Distribution and density of TNF immunoreactivity in chronic inflammatory bowel disease.
Advances in experimental medicine and biology 1995;371B():1327-30.
1994: R M Beattie; E J Schiffrin; Anne Donnet-Hughes; A C Huggett; P Domizio; Thomas T MacDonald; John Walker-Smith
Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease.
Alimentary pharmacology & therapeutics 1994;8(6):609-15.
1994: R Karttunnen; E J Breese; John Walker-Smith; Thomas T MacDonald
Decreased mucosal interleukin-4 (IL-4) production in gut inflammation.
Journal of clinical pathology 1994;47(11):1015-8.
1994: Thomas T MacDonald
Development of mucosal immune function in man: potential for GI disease states.
Acta paediatrica Japonica; Overseas edition 1994;36(5):532-6.
1994: S Nicholls; P Domizio; C B Williams; A Dawnay; C P Braegger; Thomas T MacDonald; John Walker-Smith
Cyclosporin as initial treatment for Crohn's disease.
Archives of disease in childhood 1994;71(3):243-7.
1994: M Latthe; L Terry; Thomas T MacDonald
High frequency of CD8 alpha alpha homodimer-bearing T cells in human fetal intestine.
European journal of immunology 1994;24(7):1703-5.
1994: E J Breese; C A Michie; S W Nicholls; Simon H Murch; C B Williams; P Domizio; John Walker-Smith; Thomas T MacDonald
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.
Gastroenterology 1994;106(6):1455-66.
1994: Thomas T MacDonald; J Spencer; Simon H Murch; M Y Choy; S Venugopal; Donald A P Bundy; E S Cooper
Immunoepidemiology of intestinal helminthic infections. 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(3):265-8.
1994: Thomas T MacDonald; J Spencer
Ontogeny of the gut-associated lymphoid system in man.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1994;83(395):3-5.
1993: Thomas T MacDonald; Simon H Murch; S W Nicholls; E J Breese
Diarrhoeal disease: current concepts and future challenges. Intestinal cytokines in inflammatory bowel disease and invasive diarrhoea.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1993;87 Suppl 3():23-6.
1993: Simon H Murch; C P Braegger; John Walker-Smith; Thomas T MacDonald
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
Gut 1993;34(12):1705-9.
1993: S Nicholls; S Stephens; C P Braegger; John Walker-Smith; Thomas T MacDonald
Cytokines in stools of children with inflammatory bowel disease or infective diarrhoea.
Journal of clinical pathology 1993;46(8):757-60.
1993: P Lionetti; E Breese; C P Braegger; Simon H Murch; J Taylor; Thomas T MacDonald
T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine.
Gastroenterology 1993;105(2):373-81.
1993: Thomas T MacDonald
Aetiology of Crohn's disease.
Archives of disease in childhood 1993;68(5):623-5.
1993: Simon H Murch; Thomas T MacDonald; John Walker-Smith; M Levin; P Lionetti; N J Klein
Disruption of sulphated glycosaminoglycans in intestinal inflammation.
Lancet 1993;341(8847):711-4.
1993: P Lionetti; J Spencer; E J Breese; Simon H Murch; J Taylor; Thomas T MacDonald
Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B.
European journal of immunology 1993;23(3):664-8.
1993: E Breese; C P Braegger; C J Corrigan; John Walker-Smith; Thomas T MacDonald
Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.
Immunology 1993;78(1):127-31.
1993: C P Braegger; T Torresani; Simon H Murch; M O Savage; John Walker-Smith; Thomas T MacDonald
Urinary growth hormone in growth-impaired children with chronic inflammatory bowel disease.
Journal of pediatric gastroenterology and nutrition 1993;16(1):49-52.
1992: Thomas T MacDonald; J Spencer
Cell-mediated immune injury in the intestine.
Gastroenterology clinics of North America 1992;21(2):367-86.
1992: Simon H Murch; C P Braegger; W C Sessa; Thomas T MacDonald
High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis.
Lancet 1992;339(8790):381-5.
1992: C P Braegger; S Nicholls; Simon H Murch; S Stephens; Thomas T MacDonald
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation.
Lancet 1992;339(8785):89-91.
1992: E S Cooper; C A Whyte-Alleng; J S Finzi-Smith; Thomas T MacDonald
Intestinal nematode infections in children: the pathophysiological price paid.
Parasitology 1992;104 Suppl():S91-103.
1992: Thomas T MacDonald
Epithelial proliferation in response to gastrointestinal inflammation.
Annals of the New York Academy of Sciences 1992;664():202-9.
1991: E S Cooper; J Spencer; C A Whyte-Alleng; O Cromwell; P Whitney; S Venugopal; Donald A P Bundy; B Haynes; Thomas T MacDonald
Immediate hypersensitivity in colon of children with chronic Trichuris trichiura dysentery.
Lancet 1991;338(8775):1104-7.
1991: Simon H Murch; V A Lamkin; M O Savage; John Walker-Smith; Thomas T MacDonald
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.
Gut 1991;32(8):913-7.
1991: Thomas T MacDonald; M Y Choy; J Spencer; P I Richman; T Diss; B Hanchard; S Venugopal; Donald A P Bundy; E S Cooper
Histopathology and immunohistochemistry of the caecum in children with the Trichuris dysentery syndrome.
Journal of clinical pathology 1991;44(3):194-9.
1990: J L Viney; Thomas T MacDonald
Selective death of T cell receptor gamma/delta+ intraepithelial lymphocytes by apoptosis.
European journal of immunology 1990;20(12):2809-12.
1990: M Y Choy; John Walker-Smith; C B Williams; Thomas T MacDonald
Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.
Gut 1990;31(12):1365-70.
1990: C P Braegger; C J Corrigan; Thomas T MacDonald
Finger clubbing and tumour necrosis factor alpha.
Lancet 1990;336(8717):759-60.
1990: J Viney; Thomas T MacDonald; J Spencer
Gamma/delta T cells in the gut epithelium.
Gut 1990;31(8):841-4.
1990: Thomas T MacDonald; P Hutchings; M Y Choy; Simon H Murch; A Cooke
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.
Clinical and experimental immunology 1990;81(2):301-5.
1990: J L Viney; P J Kilshaw; Thomas T MacDonald
Cytotoxic alpha/beta+ and gamma/delta+ T cells in murine intestinal epithelium.
European journal of immunology 1990;20(7):1623-6.
1990: R C Ferreira; L E Forsyth; P I Richman; C Wells; J Spencer; Thomas T MacDonald
Changes in the rate of crypt epithelial cell proliferation and mucosal morphology induced by a T-cell-mediated response in human small intestine.
Gastroenterology 1990;98(5 Pt 1):1255-63.
1990: E S Cooper; D A Bundy; Thomas T MacDonald; M H Golden
Growth suppression in the Trichuris dysentery syndrome.
European journal of clinical nutrition 1990;44(4):285-91.
1990: Thomas T MacDonald; M A Horton; M Y Choy; P I Richman
Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.
Journal of clinical pathology 1990;43(4):313-5.
1990: Thomas T MacDonald; J Spencer
Ontogeny of the mucosal immune response.
Springer seminars in immunopathology 1990;12(2-3):129-37.
1990: M Y Choy; P I Richman; M A Horton; Thomas T MacDonald
Expression of the VLA family of integrins in human intestine.
The Journal of pathology 1990;160(1):35-40.
1989: J L Viney; Thomas T MacDonald; P J Kilshaw
Alpha beta T cell receptor expression in rat intestinal epithelium.
Immunology letters 1989;23(1):49-53.
1989: J L Viney; Thomas T MacDonald; P J Kilshaw
T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice.
Immunology 1989;66(4):583-7.
1988: T Monk; J Spencer; N Cerf-Bensussan; Thomas T MacDonald
Stimulation of mucosal T cells in situ with anti-CD3 antibody: location of the activated T cells and their distribution within the mucosal micro-environment.
Clinical and experimental immunology 1988;74(2):216-22.
1988: Thomas T MacDonald; A Weinel; J Spencer
HLA-DR expression in human fetal intestinal epithelium.
Gut 1988;29(10):1342-8.
1988: Thomas T MacDonald; J Spencer
Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.
The Journal of experimental medicine 1988;167(4):1341-9.
1987: Thomas T MacDonald; J Spencer; J L Viney; C B Williams; John Walker-Smith
Selective biopsy of human Peyer's patches during ileal endoscopy.
Gastroenterology 1987;93(6):1356-62.
1987: Thomas T MacDonald; S B Dillon
Limiting dilution analysis of functional T cells in the gut mucosa.
Advances in experimental medicine and biology 1987;216A():131-41.