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Philip E. auron

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Chemicals & Drugs

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Molecular Sequence Data

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Anguo Liu; Darren Perkins; Adam C Puché; Vladimir Toshchakov; Stefanie N Vogel; Kent Z Q Wang; Philip E. auron; Douglas D Bannerman; Elizabeth A Cates; Shengyun Fang; Ping Gong; Sang Won Hyun; Simeon E Goldblum
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.
Kent Z Q Wang; Deborah L Galson; Philip E. auron
TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination.
James A Listman; JoAnne E Race; Nancy Walker-Kopp; Sebnem Unlu; Philip E. auron
Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.

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2012: Anguo Liu; Darren Perkins; Adam C Puché; Vladimir Toshchakov; Stefanie N Vogel; Kent Z Q Wang; Philip E. auron; Douglas D Bannerman; Elizabeth A Cates; Shengyun Fang; Ping Gong; Sang Won Hyun; Simeon E Goldblum
TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.
The Journal of biological chemistry 2012;287(20):16132-45.
2010: Kent Z Q Wang; Deborah L Galson; Philip E. auron
TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination.
Journal of cellular biochemistry 2010;110(3):763-71.
2008: James A Listman; JoAnne E Race; Nancy Walker-Kopp; Sebnem Unlu; Philip E. auron
Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.
Molecular immunology 2008;45(9):2667-77.
2007: Shaun Mahony; Philip E. auron; Panayiotis V Benos
Inferring protein-DNA dependencies using motif alignments and mutual information.
Bioinformatics (Oxford, England) 2007;23(13):i297-304.
2007: Sebnem Unlu; Arvind Kumar; Wayne R Waterman; Junichi Tsukada; Kent Z Q Wang; Deborah L Galson; Philip E. auron
Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene.
Molecular immunology 2007;44(13):3364-79.
2007: Jinbo Yang; Xudong Liao; Mukesh K Agarwal; Laura Barnes; Philip E. auron; George R Stark
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB.
Genes & development 2007;21(11):1396-408.
2007: Philip E. auron; Andrew C Webb; Lanny J Rosenwasser; Steven F Mucci; Alexander Rich; Sheldon M Wolff; Charles A Dinarello
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5413-7.
2007: Shaun Mahony; Philip E. auron; Panayiotis V Benos
DNA familial binding profiles made easy: comparison of various motif alignment and clustering strategies.
PLoS computational biology 2007;3(3):e61.
2006: Kent Z Q Wang; Nawarat Wara-aswapati; Jason A Boch; Yasuhiro Yoshida; Chang-Deng Hu; Deborah L Galson; Philip E. auron
TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.
Journal of cell science 2006;119(Pt 8):1579-91.
2006: Wayne R Waterman; Li Lian Xu; Sotirios Tetradis; Gabriela Motyckova; Junichi Tsukada; Kazuyoshi Saito; Andrew C Webb; Dwight R Robinson; Philip E. auron
Glucocorticoid inhibits the human pro-interleukin lbeta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer.
Molecular immunology 2006;43(7):773-82.
2005: James A Listman; Nawarat Wara-aswapati; JoAnne E Race; Lisa W Blystone; Nancy Walker-Kopp; Zhiyong Yang; Philip E. auron
Conserved ETS domain arginines mediate DNA binding, nuclear localization, and a novel mode of bZIP interaction.
The Journal of biological chemistry 2005;280(50):41421-8.
2004: Yasuhiro Yoshida; Arvind Kumar; Yoshinobu Koyama; Haibing Peng; Ahmet Arman; Jason A Boch; Philip E. auron
Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism.
The Journal of biological chemistry 2004;279(3):1768-76.
2003: Lujian Tan; Haibing Peng; Makoto Osaki; Bob K Choy; Philip E. auron; Linda J Sandell; Mary B Goldring
Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta.
The Journal of biological chemistry 2003;278(20):17688-700.
2003: Jason A Boch; Yasuhiro Yoshida; Yoshinobu Koyama; Nawarat Wara-aswapati; Hiabing Peng; Sebnem Unlu; Philip E. auron
Characterization of a cascade of protein interactions initiated at the IL-1 receptor.
Biochemical and biophysical research communications 2003;303(2):525-31.
2003: Nawarat Wara-aswapati; Jason A Boch; Philip E. auron
Activation of interleukin 1beta gene transcription by human cytomegalovirus: molecular mechanisms and relevance to periodontitis.
Oral microbiology and immunology 2003;18(2):67-71.
2003: Ahmet Arman; Philip E. auron
Interleukin 1 (IL-1) induces the activation of Stat3.
Advances in experimental medicine and biology 2003;534():297-307.
2003: Makoto Osaki; Lujian Tan; Bob K Choy; Yasuhiro Yoshida; Kathryn S E Cheah; Philip E. auron; Mary B Goldring
The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2.
The Biochemical journal 2003;369(Pt 1):103-15.
2002: Zhiyong Yang; Nawarat Wara-aswapati; Yasuhiro Yoshida; Nancy Walker; Deborah L Galson; James Listman; Philip E. auron
Dual regulatory role of human cytomegalovirus immediate-early protein in IL1B transcription is dependent upon Spi-1/PU.1.
Biochemical and biophysical research communications 2002;294(4):854-63.
2002: Alexzander Asea; Michael Rehli; Edith Kabingu; Jason A Boch; Olivia Bare; Philip E. auron; Mary Ann Stevenson; Stuart K Calderwood
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.
The Journal of biological chemistry 2002;277(17):15028-34.
2002: Yue Xie; Changmin Chen; Mary Ann Stevenson; Philip E. auron; Stuart K Calderwood
Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.
The Journal of biological chemistry 2002;277(14):11802-10.
2002: Eric S Silverman; Louis Le; Rebecca M Baron; Arlene Hallock; Josephine Hjoberg; Toshiki Shikanai; Karin Storm van's Gravesande; Philip E. auron; Weining Lu
Cloning and functional analysis of the mouse 5-lipoxygenase promoter.
American journal of respiratory cell and molecular biology 2002;26(4):475-83.
2002: Yue Xie; Changmin Chen; Mary Ann Stevenson; David A Hume; Philip E. auron; Stuart K Calderwood
NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells.
Biochemical and biophysical research communications 2002;291(4):1071-80.
2002: Yoko Toda; Junichi Tsukada; Masahiro Misago; Yoshihiko Kominato; Philip E. auron; Yoshiya Tanaka
Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1984-91.
2001: F B Riquet; Lujian Tan; Bob K Choy; Makoto Osaki; Gerard Karsenty; T F Osborne; Philip E. auron; Mary B Goldring
YY1 is a positive regulator of transcription of the Col1a1 gene.
The Journal of biological chemistry 2001;276(42):38665-72.
2001: Jason A Boch; Nawarat Wara-aswapati; Philip E. auron
Interleukin 1 signal transduction--current concepts and relevance to periodontitis.
Journal of dental research 2001;80(2):400-7.
2001: Ellen M Gravallese; Deborah L Galson; Steven R Goldring; Philip E. auron
The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.
Arthritis research 2001;3(1):6-12.
2000: Z Yang; Nawarat Wara-aswapati; C Chen; Junichi Tsukada; Philip E. auron
NF-IL6 (C/EBPbeta ) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether.
The Journal of biological chemistry 2000;275(28):21272-7.
2000: Junichi Tsukada; Yoko Toda; Masahiro Misago; Yoshiya Tanaka; Philip E. auron; Sumiya Eto
Constitutive activation of LIL-Stat in adult T-cell leukemia cells.
Blood 2000;95(8):2715-8.
1999: Nawarat Wara-aswapati; Z Yang; Wayne R Waterman; Y Koyama; Sotirios Tetradis; Bob K Choy; Andrew C Webb; Philip E. auron
Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1.
Molecular and cellular biology 1999;19(10):6803-14.
1999: P Zhang; Gerhard Behre; J Pan; A Iwama; Nawarat Wara-aswapati; Hanna S Radomska; Philip E. auron; Daniel G Tenen; Z Sun
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8705-10.
1999: Alberto Bavelloni; Spartaco Santi; Alessandra Sirri; Massimo Riccio; Irene Faenza; Nicoletta Zini; S Cecchi; A Ferri; Philip E. auron; Nadir M Maraldi; Sandra Marmiroli
Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells.
Journal of cell science 1999;112 ( Pt 5)():631-40.
1999: Y Xie; C M Cahill; Alexzander Asea; Philip E. auron; Stuart K Calderwood
Heat shock proteins and regulation of cytokine expression.
Infectious diseases in obstetrics and gynecology 1999;7(1-2):26-30.
1998: Sandra Marmiroli; Alberto Bavelloni; Irene Faenza; Alessandra Sirri; Andrea Ognibene; Vittoria Cenni; J Tsukada; Y Koyama; Maria Ruzzene; A Ferri; Philip E. auron; Alex Toker; Nadir M Maraldi
Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I.
FEBS letters 1998;438(1-2):49-54.
1998: Philip E. auron
The interleukin 1 receptor: ligand interactions and signal transduction.
Cytokine & growth factor reviews 1998;9(3-4):221-37.
1997: C Chen; Y Xie; Mary Ann Stevenson; Philip E. auron; Stuart K Calderwood
Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene.
The Journal of biological chemistry 1997;272(43):26803-6.
1997: Junichi Tsukada; Masahiro Misago; Y Serino; R Ogawa; S Murakami; M Nakanishi; S Tonai; Yoshihiko Kominato; Isao Morimoto; Philip E. auron; Sumiya Eto
Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1.
Blood 1997;90(8):3142-53.
1996: Y Koyama; Yoshiya Tanaka; Kazuyoshi Saito; M Abe; K Nakatsuka; Isao Morimoto; Philip E. auron; Sumiya Eto
Cross-linking of intercellular adhesion molecule 1 (CD54) induces AP-1 activation and IL-1beta transcription.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5097-103.
1996: C M Cahill; W R Waterman; Y Xie; Philip E. auron; Stuart K Calderwood
Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1.
The Journal of biological chemistry 1996;271(40):24874-9.
1996: Junichi Tsukada; W R Waterman; Y Koyama; A C Webb; Philip E. auron
A novel STAT-like factor mediates lipopolysaccharide, interleukin 1 (IL-1), and IL-6 signaling and recognizes a gamma interferon activation site-like element in the IL1B gene.
Molecular and cellular biology 1996;16(5):2183-94.
1996: D R Robinson; Masaharu Urakaze; R Huang; Hirofumi Taki; E Sugiyama; C T Knoell; L Xu; E T Yeh; Philip E. auron
Dietary marine lipids suppress continuous expression of interleukin-1 beta gene transcription.
Lipids 1996;31 Suppl():S23-31.
1996: Z Sun; D A Yergeau; I C Wong; T Tuypens; J Tavernier; Cassandra C Paul; Michael A Baumann; Philip E. auron; Daniel G Tenen; Steven J Ackerman
Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development: identification of a unique cis-element that acts lie an enhancer in regulating activity of the IL-5R alpha promoter.
Current topics in microbiology and immunology 1996;211():173-87.
1995: Yoshihiko Kominato; D Galson; W R Waterman; A C Webb; Philip E. auron
Monocyte expression of the human prointerleukin 1 beta gene (IL1B) is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1.
Molecular and cellular biology 1995;15(1):58-68.
1994: Junichi Tsukada; K Saito; W R Waterman; A C Webb; Philip E. auron
Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene.
Molecular and cellular biology 1994;14(11):7285-97.
1994: Philip E. auron; A C Webb
Interleukin-1: a gene expression system regulated at multiple levels.
European cytokine network 1994;5(6):573-92.
1994: D R Robinson; L L Xu; C T Knoell; S Tateno; M Guo; Robert Colvin; W Olesiak; Masaharu Urakaze; E Sugiyama; Philip E. auron
Alleviation of autoimmune disease by omega 3 fatty acids.
World review of nutrition and dietetics 1994;76():95-102.
1993: D L Galson; Jack O Hensold; T R Bishop; Martin Schalling; Alan D D'Andrea; C Jones; Philip E. auron; David E Housman
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis.
Molecular and cellular biology 1993;13(5):2929-41.
1993: F Shirakawa; K Saito; C A Bonagura; D L Galson; Matthew J Fenton; A C Webb; Philip E. auron
The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.
Molecular and cellular biology 1993;13(3):1332-44.
1992: A H Gorn; H Y Lin; M Yamin; Philip E. auron; M R Flannery; D R Tapp; C A Manning; Harvey Lodish; Stephen M Krane; Steven R Goldring
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
The Journal of clinical investigation 1992;90(5):1726-35.
1992: Gary W Hunninghake; Brian G Monks; LJ Geist; Martha M Monick; M. Alexandra Monroy; Mark F Stinski; A C Webb; J M Dayer; Philip E. auron; Matthew J Fenton
The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation.
Molecular and cellular biology 1992;12(8):3439-48.
1992: Philip E. auron; G J Quigley; L J Rosenwasser; Lee Gehrke
Multiple amino acid substitutions suggest a structural basis for the separation of biological activity and receptor binding in a mutant interleukin-1 beta protein.
Biochemistry 1992;31(29):6632-8.
1992: J W Crump; LJ Geist; Philip E. auron; A C Webb; Mark F Stinski; Gary W Hunninghake
The immediate early genes of human cytomegalovirus require only proximal promoter elements to upregulate expression of interleukin-1 beta.
American journal of respiratory cell and molecular biology 1992;6(6):674-7.
1991: W Conca; Philip E. auron; M Aoun-Wathne; N Bennett; P Seckinger; H G Welgus; Steven R Goldring; S P Eisenberg; J M Dayer; Stephen M Krane
An interleukin 1 beta point mutant demonstrates that jun/fos expression is not sufficient for fibroblast metalloproteinase expression.
The Journal of biological chemistry 1991;266(25):16265-8.
1990: Jack T Rogers; K R Bridges; G P Durmowicz; J Glass; Philip E. auron; H N Munro
Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1.
The Journal of biological chemistry 1990;265(24):14572-8.
1990: G K Iwamoto; Martha M Monick; B D Clark; Philip E. auron; Mark F Stinski; Gary W Hunninghake
Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus.
The Journal of clinical investigation 1990;85(6):1853-7.
1990: Lee Gehrke; Steve Jobling; L S Paik; B McDonald; L J Rosenwasser; Philip E. auron
A point mutation uncouples human interleukin-1 beta biological activity and receptor binding.
The Journal of biological chemistry 1990;265(11):5922-5.
1990: J A Samia; S J Alexander; K W Horton; Philip E. auron; M G Byers; T B Shows; A C Webb
Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin.
Genomics 1990;6(1):159-67.
1989: L Dudding; S Haskill; B D Clark; Philip E. auron; S Sporn; E S Huang
Cytomegalovirus infection stimulates expression of monocyte-associated mediator genes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3343-52.
1988: Steve Jobling; Philip E. auron; G Gurka; A C Webb; B McDonald; L J Rosenwasser; Lee Gehrke
Biological activity and receptor binding of human prointerleukin-1 beta and subpeptides.
The Journal of biological chemistry 1988;263(31):16372-8.
1988: Philip E. auron; D Sullivan; Matthew J Fenton; B D Clark; E S Cole; D L Galson; L Peters; D Teller
The Nucleic Acid Blot Analyzer II. ANALYZE, an image analysis software package for molecular biology.
BioTechniques 1988;6(4):347-53.
1988: Matthew J Fenton; M W Vermeulen; B D Clark; A C Webb; Philip E. auron
Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(7):2267-73.
1987: A C Webb; Kathleen L Collins; S E Snyder; S J Alexander; L J Rosenwasser; R L Eddy; T B Shows; Philip E. auron
Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.
The Journal of experimental medicine 1987;166(1):77-94.
1987: Matthew J Fenton; B D Clark; Kathleen L Collins; A C Webb; A Rich; Philip E. auron
Transcriptional regulation of the human prointerleukin 1 beta gene.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(11):3972-9.
1987: Philip E. auron; A C Webb
The structure and regulation of the human prointerleukin-1 beta gene.
Annales de l'Institut Pasteur. Immunology 1987;138(3):462-9.
1987: Philip E. auron; S J Warner; A C Webb; Joseph Cannon; H A Bernheim; K J McAdam; L J Rosenwasser; G LoPreste; S F Mucci; Charles A Dinarello
Studies on the molecular nature of human interleukin 1.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(5):1447-56.
1986: B D Clark; Kathleen L Collins; M S Gandy; A C Webb; Philip E. auron
Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.
Nucleic acids research 1986;14(20):7897-914.
1986: L J Rosenwasser; A C Webb; B D Clark; S Irie; L Chang; C A Dinarello; Lee Gehrke; S M Wolff; A Rich; Philip E. auron
Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(14):5243-6.
1986: Charles A Dinarello; Joseph Cannon; James W Mier; H A Bernheim; G LoPreste; D L Lynn; R N Love; A C Webb; Philip E. auron; R C Reuben
Multiple biological activities of human recombinant interleukin 1.
The Journal of clinical investigation 1986;77(6):1734-9.
1986: S M Wolff; Philip E. auron; C A Dinarello; L J Rosenwasser; A C Webb; A Rich
Clone controversy at Immunex.
Nature 1986;319(6051):270.
1986: A C Webb; Kathleen L Collins; Philip E. auron; R L Eddy; H Nakai; M G Byers; L L Haley; W M Henry; TB Shows
Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
Lymphokine research 1986;5(2):77-85.
1985: Philip E. auron; L J Rosenwasser; K Matsushima; T Copeland; C A Dinarello; J J Oppenheim; A C Webb
Human and murine interleukin 1 possess sequence and structural similarities.
The Journal of molecular and cellular immunology : JMCI 1985;2(3):169-77.
1984: Philip E. auron; A C Webb; L J Rosenwasser; S F Mucci; A Rich; S M Wolff; C A Dinarello
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7907-11.
1984: G J Quigley; Lee Gehrke; D A Roth; Philip E. auron
Computer-aided nucleic acid secondary structure modeling incorporating enzymatic digestion data.
Nucleic acids research 1984;12(1 Pt 1):347-66.
1983: Lee Gehrke; Philip E. auron; G J Quigley; A Rich; N Sonenberg
5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation.
Biochemistry 1983;22(22):5157-64.
1982: Philip E. auron; L D Weber; A Rich
Comparison of transfer ribonucleic acid structures using cobra venom and S1 endonucleases.
Biochemistry 1982;21(19):4700-6.
1982: Philip E. auron; W P Rindone; C P Vary; J J Celentano; john vournakis
Computer-aided prediction of RNA secondary structures.
Nucleic acids research 1982;10(1):403-19.
1981: Philip E. auron; S R Fahnestock
Functional organization of the large ribosomal subunit of Bacillus stearothermophilus.
The Journal of biological chemistry 1981;256(19):10105-10.
1978: Philip E. auron; K J Erdelsky; S R Fahnestock
Chemical modification studies of a protein at the peptidyltransferase site of the Bacillus stearothermophilus ribosome. The 50 S ribosomal subunit is a highly integrated functional unit.
The Journal of biological chemistry 1978;253(19):6893-900.