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Werner Krause

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Werner Krause; Andreas Jordan; Regina Scholz; José-Luis Martin Jimenez
Iodinated nitroimidazoles as radiosensitizers.
Werner Krause; Thomas Gilles
A new animal model for testing renal tolerance of contrast agents.
Werner Krause; Matthias Schromm
Use of additives to contrast media to improve imaging in plain film and computed tomography urography.

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All Publications

2005: Werner Krause; Andreas Jordan; Regina Scholz; José-Luis Martin Jimenez
Iodinated nitroimidazoles as radiosensitizers.
Anticancer research 2005;25(3B):2145-51.
2003: Werner Krause; Thomas Gilles
A new animal model for testing renal tolerance of contrast agents.
Investigative radiology 2003;38(11):704-11.
2003: Werner Krause; Matthias Schromm
Use of additives to contrast media to improve imaging in plain film and computed tomography urography.
Investigative radiology 2003;38(1):17-26.
2002: Werner Krause; P Muschick; U Krüger
Use of near-infrared reflection spectroscopy to study the effects of X-ray contrast media on renal tolerance in rats: effects of a prostacyclin analogue and of phosphodiesterase inhibitors.
Investigative radiology 2002;37(12):698-705.
2002: Werner Krause; Kerstin Handreke; G Schuhmann-Giampieri; K Rupp
Efficacy of the iodine-free computed tomography liver contrast agent, Dy-EOB-DTPA, in comparison with a conventional iodinated agent in normal and in tumor-bearing rabbits.
Investigative radiology 2002;37(5):241-7.
2001: Werner Krause; M Mahler; B Hanke; W Milius; J Kaufmann; P Rogalla; B Hamm
Dy-EOB-DTPA: tolerance and pharmacokinetics in healthy volunteers and preliminary liver imaging in patients.
Investigative radiology 2001;36(8):431-44.
2001: Ralf Schindler; C Stahl; St Venz; K Ludat; Werner Krause; Ulrich Frei
Removal of contrast media by different extracorporeal treatments.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(7):1471-4.
2000: TR Bader; Florian Grabenwöger; Rupert W Prokesch; Werner Krause
Measurement of hepatic perfusion with dynamic computed tomography: assessment of normal values and comparison of two methods to compensate for motion artifacts.
Investigative radiology 2000;35(9):539-47.
2000: Werner Krause; S Gerlach; P Muschick
Prevention of the hemodynamic effects of iopromide-carrying liposomes in rats and pigs.
Investigative radiology 2000;35(8):493-503.
2000: J J M L Hoffmann; A V Tielbeek; Werner Krause
Haemostatic effects of low osmolar non-ionic and ionic contrast media: a double-blind comparative study.
The British journal of radiology 2000;73(867):248-55.
1999: A I Kugoev; Werner Krause; S L Timerbaeva; R Wegener
Pharmacokinetics and tolerability of iopromide 240 after lumbar myelography.
Investigative radiology 1999;34(11):692-7.
1999: Werner Krause; Reinhard Gröll; R Kern; C Baumgartner; Rainer Rienmüller
Application of pharmacokinetics to electron-beam tomography of the abdomen.
Academic radiology 1999;6(8):487-95.
1999: Udo P Schmiedl; Werner Krause; JU Leike; A Sachse
CT blood pool enhancement in primates with lopromide-carrying liposomes containing soy phosphatidyl glycerol.
Academic radiology 1999;6(3):164-9.
1998: Sameh K Morcos; P Dawson; Jeremy Pearson; J Y Jeremy; A P Davenport; M S Yates; P Tirone; P Cipolla; Christoph de Haen; P Muschick; Werner Krause; H Refsum; C J Emery; P Liss; A Nygren; John L Haylor; N D Pugh; Jan Olof Gustav Karlsson
The haemodynamic effects of iodinated water soluble radiographic contrast media: a review.
European journal of radiology 1998;29(1):31-46.
1998: U Speck; F Böhle; Werner Krause; J L Martin; H Miklautz; G Schuhmann-Giampieri
Delayed hypersensitivity to X-ray CM: possible mechanisms and models.
Academic radiology 1998;5 Suppl 1():S162-5; discussion S166.
1998: Werner Krause
In vitro and animal experiments in contrast media testing.
Investigative radiology 1998;33(3):182-91.
1997: Stephan Albert Schmitz; Susanne Wagner; G Schuhmann-Giampieri; Werner Krause; Matthias Bollow; Karl-Jürgen Wolf
Gd-EOB-DTPA and Yb-EOB-DTPA: two prototypic contrast media for CT detection of liver lesions in dogs.
Radiology 1997;205(2):361-6.
1997: Werner Krause; W R Press
Influence of contrast media on blood coagulation.
Investigative radiology 1997;32(5):249-59.
1997: Stephan Albert Schmitz; Susanne Wagner; G Schuhmann-Giampieri; Werner Krause; Karl-Jürgen Wolf
A prototype liver-specific contrast medium for CT: preclinical evaluation of gadoxetic acid disodium, or Gd-EOB-DTPA.
Radiology 1997;202(2):407-12.
1997: A Sachse; JU Leike; T Schneider; S E Wagner; G L Rössling; Werner Krause; Martin Brandl
Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated iopromide-carrying liposomes.
Investigative radiology 1997;32(1):44-50.
1996: Werner Krause; G Schuhmann-Giampieri; M Bauer; W R Press; P Muschick
Ytterbium- and dysprosium-EOB-DTPA. A new prototype of liver-specific contrast agents for computed tomography.
Investigative radiology 1996;31(8):502-11.
1996: Werner Krause; J Leike; G Schuhmann-Giampieri; A Sachse; Udo P Schmiedl; H Strunk
Iopromide-carrying liposomes as a contrast agent for the liver.
Academic radiology 1996;3 Suppl 2():S235-7.
1996: Werner Krause
Application of pharmacokinetics to computed tomography: injection rates and schemes: mono-, bi-, or multiphasic?
Investigative radiology 1996;31(2):91-100.
1996: Werner Krause; D Niehues
Biochemical characterization of x-ray contrast media.
Investigative radiology 1996;31(1):30-42.
1995: P Muschick; D Wehrmann; G Schuhmann-Giampieri; Werner Krause
Cardiac and hemodynamic tolerability of iodinated contrast media in the anesthetized rat.
Investigative radiology 1995;30(12):745-53.
1995: Udo P Schmiedl; Werner Krause; J Leike; J A Nelson; G Schuhmann-Giampieri
Liver contrast enhancement in primates using iopromide liposomes.
Academic radiology 1995;2(11):967-72.
1995: Werner Krause; T Bunte; R Schubert; P Blaszkiewicz
The lack of immunogenicity of iotrolan.
Investigative radiology 1995;30(9):548-51.
1995: G Schuhmann-Giampieri; J Leike; A Sachse; Werner Krause
Pharmacokinetics of iopromide liposomes in rabbits.
Pharmaceutical research 1995;12(7):1065-71.
1995: R Klopp; W Niemer; W Schippel; Werner Krause
Changes in the microcirculation of the intact rat heart after iodinated and gadolinium-containing contrast media.
Investigative radiology 1995;30(2):69-74.
1995: Werner Krause; T Miyazawa; R Uchimoto; C Murayama; B Fritz-Zieroth; W R Press; T Frenzel
Comparison of iopamidol and ioversol in vitro and in animal studies.
Arzneimittel-Forschung 1995;45(2):200-4.
1995: Werner Krause; F Reissmann; G Kühne; C Schöbel
Circadian plasma level profile of lisuride in rats and mice after continuous administration via the diet.
Arzneimittel-Forschung 1995;45(1):6-10.
1994: Werner Krause; C Schöbel; W R Press
Preclinical testing of iopromide. 2nd communication: toxicological evaluation.
Arzneimittel-Forschung 1994;44(11):1275-9.
1994: Werner Krause; P Muschick; D Wehrmann
Cardiac and hemodynamic tolerability of iopromide with or without sodium or iloprost and of ioversol in the anesthetized rat.
Investigative radiology 1994;29(11):978-84.
1994: Werner Krause; R Klopp; W Niemer; W Schippel; H Kulmann
Elimination of the diatrizoate-induced effects on the microcirculation by the prostacyclin derivative, iloprost.
Investigative radiology 1994;29(10):922-7.
1994: Werner Krause; W R Press; T Frenzel
Preclinical testing of iopromide. 1st communication: pharmacological evaluation.
Arzneimittel-Forschung 1994;44(10):1162-6.
1994: C Ehritt-Braun; F Ferstl; A Brehm; Werner Krause; Mathias Langer
[Optimizing intravenous bolus contrast medium injection in cervical CT diagnosis].
Aktuelle Radiologie 1994;4(5):222-4.
1994: Werner Krause
Preclinical characterization of iopromide.
Investigative radiology 1994;29 Suppl 1():S21-32.
1994: C Ehritt-Braun; F Ferstl; D Burger; Werner Krause; Mathias Langer
[Optimizing and adjusting the intravenous contrast medium in the CT diagnosis of the thorax].
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 1994;160(4):364-5.
1994: Werner Krause; G Kühne
Anti-inflammatory activity of rolipram in a rat ear edema model.
Arzneimittel-Forschung 1994;44(2):163-5.
1994: Werner Krause; H Miklautz; U Kollenkirchen; G Heimann
Physicochemical parameters of x-ray contrast media.
Investigative radiology 1994;29(1):72-80.
1994: Werner Krause; G Schuhmann-Giampieri; T Staks; J Kaufmann
Dose proportionality of iopromide pharmacokinetics and tolerability after i.v. injection in healthy volunteers.
European journal of clinical pharmacology 1994;46(4):339-43.
1993: Werner Krause; G Kühne
Biotransformation of the antidepressant D,L-rolipram. II. Metabolite patterns in man, rat, rabbit, rhesus and cynomolgus monkey.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(11):1277-88.
1993: Werner Krause; J Leike; A Sachse; G Schuhmann-Giampieri
Characterization of iopromide liposomes.
Investigative radiology 1993;28(11):1028-32.
1993: A Sachse; J U Leike; G L Rössling; S E Wagner; Werner Krause
Preparation and evaluation of lyophilized iopromide-carrying liposomes for liver tumor detection.
Investigative radiology 1993;28(9):838-44.
1993: Werner Krause; G Kühne; U Jakobs; G A Hoyer
Biotransformation of the antidepressant DL-rolipram. I. Isolation and identification of metabolites from rat, monkey, and human urine.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(4):682-9.
1993: Werner Krause; R Dorow
Pharmacokinetics of two partial benzodiazepine receptor agonistic beta-carboline derivatives in healthy volunteers.
Arzneimittel-Forschung 1993;43(5):511-5.
1993: Theodora Duka; B Schütt; Werner Krause; R Dorow; S McDonald; K Fichte
Human studies on abecarnil a new beta-carboline anxiolytic: safety, tolerability and preliminary pharmacological profile.
British journal of clinical pharmacology 1993;35(4):386-94.
1993: Werner Krause; B Düsterberg; U Jakobs; G A Hoyer
Biotransformation of proterguride in the perfused rat liver.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):203-8.
1993: Theodora Duka; Werner Krause; R Dorow; A Rohloff; H Ott; B Voet
Abecarnil: a new beta-carboline anxiolytic preliminary clinical pharmacology.
Psychopharmacology series 1993;11():132-47.
1992: Werner Krause; B Mechelke
Placental transfer of the anxiolytic beta-carboline abecarnil in rabbit.
Arzneimittel-Forschung 1992;42(9):1079-82.
1992: Werner Krause; G Kühne
High-performance liquid chromatographic procedure for specificity testing of radioimmunoassays: rolipram.
Journal of chromatography 1992;573(2):303-8.
1991: Werner Krause; A Sachse; S Wagner; U Kollenkirchen; G Rössling
Preclinical characterization of iopromide-carrying liposomes.
Investigative radiology 1991;26 Suppl 1():S172-4; discussion S175-6.
1991: Werner Krause; Theodora Duka; H Matthes
Pharmacokinetics and biotransformation of the anxiolytic abecarnil in healthy volunteers.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(6):763-74.
1991: Werner Krause; F Reissmann; C Schöbel; W Schunack
Multiple intragastric treatment versus continuous administration via the diet. Comparative pharmacokinetics of abecarnil in mouse.
Xenobiotica; the fate of foreign compounds in biological systems 1991;21(6):695-708.
1991: Werner Krause; G Kühne; W Seifert
Pharmacokinetics of 3H-terguride in elderly volunteers.
Arzneimittel-Forschung 1991;41(4):373-7.
1991: Werner Krause; T Mager; G Kühne; Theodora Duka; B Voet
The pharmacokinetics and pharmacodynamics of lisuride in healthy volunteers after intravenous, intramuscular, and subcutaneous injection.
European journal of clinical pharmacology 1991;40(4):399-403.
1991: Werner Krause; F Reissmann; W Schunack; C Schöbel
Comparative pharmacokinetics of abecarnil in rat following single and multiple intragastric treatment and continuous administration via the diet.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):29-35.
1990: M Pfeffer; N Sauerbrey; F Windt-Hanke; Werner Krause
In-vitro and in-vivo characterisation of two sustained release formulations for the antidepressant rolipram.
Arzneimittel-Forschung 1990;40(11):1191-4.
1990: M Hildebrand; Werner Krause; P Angeli; T Koziol; A Gatta; C Merkel; M Bolognesi
Pharmacokinetics of iloprost in patients with hepatic dysfunction.
International journal of clinical pharmacology, therapy, and toxicology 1990;28(10):430-4.
1990: Werner Krause; U Jakobs; R Buckenauer; H Biere
Synthesis of a deuterated analogue and development of antibody/GC/MS for the determination of nocloprost in plasma.
Prostaglandins 1990;40(3):283-96.
1990: Werner Krause; B Schütt; Theodora Duka
Pharmacokinetics and acute toleration of the beta-carboline derivative abecarnil in man.
Arzneimittel-Forschung 1990;40(5):529-32.
1990: Werner Krause; H Mengel
Pharmacokinetics of the anxiolytic beta-carboline derivative abecarnil in the mouse, rat, rabbit, dog, cynomolgus monkey and baboon. Studies on species differences.
Arzneimittel-Forschung 1990;40(5):522-9.
1990: Werner Krause; H Träger; G Kühne; N Sauerbrey; K J Gräf; R Dorow
Pharmacokinetics and endocrine effects of terguride in healthy subjects.
European journal of clinical pharmacology 1990;38(6):609-15.
1990: Werner Krause; G Kühne; N Sauerbrey
Pharmacokinetics of (+)-rolipram and (-)-rolipram in healthy volunteers.
European journal of clinical pharmacology 1990;38(1):71-5.
1990: M Hildebrand; Werner Krause; H Fabian; T Koziol; H H Neumayer
Pharmacokinetics of iloprost in patients with chronic renal failure and on maintenance haemodialysis.
International journal of clinical pharmacology research 1990;10(5):285-92.
1990: M Hildebrand; B Nieuweboer; H Biere; U Klar; G Seemann; Werner Krause; U Jakobs
Development, validation and practical use of a sensitive and specific radioimmunoassay for the determination of iloprost.
Eicosanoids 1990;3(3):165-9.
1990: M Hildebrand; Werner Krause; H A Oberender; S Zurdel-Dillinger; M Jünger; H Bodenburg
Pharmacokinetics of iloprost in patients with severe peripheral arterial occlusive disease.
Eicosanoids 1990;3(3):145-8.
1989: Werner Krause; G Gröhler
Automated high-performance liquid chromatographic assay for the beta-carboline derivative Abecarnil in plasma.
Journal of chromatography 1989;495():324-9.
1989: Werner Krause; H Mengel; L Nordholm
Determination of beta-carboline derivatives in biological samples by high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical sciences 1989;78(8):622-6.
1989: Werner Krause; G Kühne; H Matthes
Pharmacokinetics of the antidepressant rolipram in healthy volunteers.
Xenobiotica; the fate of foreign compounds in biological systems 1989;19(6):683-92.
1988: Werner Krause; M Hümpel
Pharmacokinetics of the dopamine partial agonist, terguride, in the rat and rhesus monkey.
European journal of drug metabolism and pharmacokinetics 1988;13(3):185-94.
1988: Werner Krause; G Kühne
Pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. Studies on species differences.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(5):561-71.
1988: Werner Krause; M Hümpel
Pharmacokinetics of proterguride in rat and cynomolgus monkey.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(1):41-8.
1988: Werner Krause; B Nieuweboer; S Ruggieri; Fabrizio Stocchi; I Suchy
Pharmacokinetics of lisuride after subcutaneous infusion.
Journal of neural transmission. Supplementum 1988;27():71-4.
1987: M Hildebrand; Werner Krause; G Kühne; G A Hoyer
Pharmacokinetics and metabolism of mespirenone, a new aldosterone antagonist, in rat and cynomolgus monkey.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(5):623-34.
1987: M Hilderbrand; M Hümpel; Werner Krause; U Täuber
Pharmacokinetics of bromerguride, a new dopamine-antagonistic ergot derivative in rat and dog.
European journal of drug metabolism and pharmacokinetics 1987;12(1):31-40.
1987: Theodora Duka; Dai stephens; Werner Krause; R Dorow
Human studies on the benzodiazepine receptor antagonist beta-carboline ZK 93,426: preliminary observations on psychotropic activity.
Psychopharmacology 1987;93(4):421-7.
1987: Werner Krause; T Krais
Pharmacokinetics and pharmacodynamics of radio-labeled iloprost in elderly volunteers.
European journal of clinical pharmacology 1987;32(6):597-605.
1986: B Mueller; B Maass; Werner Krause; W Witt
Limitation of myocardial unperfused area and necrotic zone 24 hours and 7 days after coronary artery ligation in rats by the stable prostacyclin analogue iloprost.
Prostaglandins, leukotrienes, and medicine 1986;21(3):331-40.
1986: Werner Krause; N Sauerbrey; K J Gräf
Pharmacokinetics and pharmacodynamics in man of the dopamine antagonist ergot derivative, bromerguride.
European journal of clinical pharmacology 1986;31(2):165-8.
1985: Werner Krause; U Jakobs; P E Schulze; B Nieuweboer; M Hümpel
Development of antibody-mediated extraction followed by GC/MS (antibody/GC/MS) and its application to iloprost determination in plasma.
Prostaglandins, leukotrienes, and medicine 1985;17(2):167-82.
1985: U Täuber; C Weiss; Werner Krause; B Acksteiner; H Matthes
Pharmacokinetics of pirazolac--a new anti-inflammatory drug--in human volunteers. I. Absorption, disposition, biotransformation and excretion.
European journal of drug metabolism and pharmacokinetics 1985;10(1):41-53.
1984: M Hümpel; Werner Krause; G A Hoyer; H Wendt; G Pommerenke
The pharmacokinetics and biotransformation of 14C-lisuride hydrogen maleate in rhesus monkey and in man.
European journal of drug metabolism and pharmacokinetics 1984;9(4):347-57.
1984: Werner Krause; M Hümpel; G A Hoyer
Biotransformation of the stable prostacyclin analogue, iloprost, in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(5):645-51.
1984: Werner Krause; R Beckmann; M Schubert
Pharmacokinetics and pharmacodynamics of the stable prostacyclin analogue, ZK 36 374, in the cat.
Prostaglandins, leukotrienes, and medicine 1984;15(2):187-97.
1984: Werner Krause; U Jakobs
Determination of 17 beta-hydroxy-1 alpha-methyl-17 alpha-propyl-5-alpha-androstan-3-one in plasma by gas chromatography-mass spectrometry with single-ion detection.
Journal of pharmaceutical sciences 1984;73(4):563-4.
1984: Werner Krause; B Nieuweboer
Development of a radioimmunoassay and its application to the pharmacokinetics of the stable prostacyclin analogue, nileprost, in the rat.
Prostaglandins, leukotrienes, and medicine 1984;14(1):1-9.
1984: Werner Krause
Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374, in the beagle dog.
Prostaglandins, leukotrienes, and medicine 1984;13(2):143-51.
1984: Werner Krause; D Kampf; H C Fischer
Pharmacokinetics of mepindolol in patients with chronic renal failure.
European journal of clinical pharmacology 1984;27(4):429-33.
1984: Werner Krause; R Dorow; B Nieuweboer; S H Hasan
Pharmacokinetics and pharmacodynamics of the ergot derivative, transdihydrolisuride, in man.
European journal of clinical pharmacology 1984;27(3):335-9.
1983: Werner Krause; J Karras; U Jakobs
Determination of canrenone, the major metabolite of spironolactone, in plasma and urine by high-performance liquid chromatography.
Journal of chromatography 1983;277():191-9.
1983: Werner Krause; C Lennert
Pharmacokinetics of mepindolol administered alone and in combination with hydrochlorothiazide--a bioequivalence study.
Biopharmaceutics & drug disposition 1983;4(4):339-45.
1983: Werner Krause; P E Schulze; M Totzek
Pharmacokinetics of the stable prostacyclin analogue, nileprost, in the rat.
Prostaglandins, leukotrienes, and medicine 1983;11(3):241-57.
1983: Werner Krause; M Schubert; M Totzek
Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374, in the monkey (Macaca fascicularis).
Prostaglandins, leukotrienes, and medicine 1983;11(3):325-38.
1983: Werner Krause; G Kühne; E Schillinger
Pharmacokinetics and biotransformation of methane sulphonanilides with anti-inflammatory activity in the rat and monkey--comparison with piroxicam.
Xenobiotica; the fate of foreign compounds in biological systems 1983;13(5):265-72.
1983: Werner Krause; B Nieuweboer
Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374. III. Development of a radioimmunoassay and its application to the pharmacokinetics of ZK 36 374 in the rat.
Prostaglandins, leukotrienes, and medicine 1983;10(3):289-99.
1983: Werner Krause; G Kühne
Pharmacokinetics of mepindolol sulfate in the rat, dog, and rhesus monkey. Studies on species differences.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(2):91-6.
1983: Werner Krause; W Schwartzkopff
Plasma levels of mepindolol in healthy volunteers after oral doses of mepindolol sulphate.
Arzneimittel-Forschung 1983;33(9):1306-7.
1983: Werner Krause; J Karras; W Seifert
Pharmacokinetics of canrenone after oral administration of spironolactone and intravenous injection of canrenoate-K in healthy man.
European journal of clinical pharmacology 1983;25(4):449-53.
1982: Werner Krause; G Kühne
Isolation and identification of spirorenone metabolites from the monkey (Macaca fascicularis).
Steroids 1982;40(1):81-90.