Werner Muller

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Thorsten Peters; Wilhelm Bloch; Oliver Pabst; Claudia Wickenhauser; Claudia Uthoff-Hachenberg; Susanne V Schmidt; Georg Varga; Stephan Grabbe; Daniel Kess; Tsvetelina Oreshkova; et al.
Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo.
Marina C Pils; André Bleich; Immo Prinz; Nicolas Fasnacht; Mariela Bollati-Fogolin; Angela Schippers; Björn Rozell; Werner Müller
Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.
Jie Sun; Amber Cardani; Ashish K Sharma; Victor E Laubach; Robert S Jack; Werner Müller; Thomas J Braciale
Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus.

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All Publications

2012: Thorsten Peters; Wilhelm Bloch; Oliver Pabst; Claudia Wickenhauser; Claudia Uthoff-Hachenberg; Susanne V Schmidt; Georg Varga; Stephan Grabbe; Daniel Kess; Tsvetelina Oreshkova; et al.
Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo.
Clinical & developmental immunology 2012;2012():450738.
2011: Marina C Pils; André Bleich; Immo Prinz; Nicolas Fasnacht; Mariela Bollati-Fogolin; Angela Schippers; Björn Rozell; Werner Müller
Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.
Inflammatory bowel diseases 2011;17(10):2038-46.
2011: Jie Sun; Amber Cardani; Ashish K Sharma; Victor E Laubach; Robert S Jack; Werner Müller; Thomas J Braciale
Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus.
PLoS pathogens 2011;7(8):e1002173.
2011: Johannes Lutz; Marinus R Heideman; Edith Roth; Paul van den Berk; Werner Müller; Chander Raman; Matthias Wabl; Heinz Jacobs; Hans-Martin Jäck
Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10644-9.
2011: Anne Dudeck; Jan Dudeck; Julia Scholten; Anke Petzold; Sangeetha Surianarayanan; Anja Köhler; Katrin Peschke; David Vöhringer; Claudia Waskow; Thomas Krieg; et al.
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
Immunity 2011;34(6):973-84.
2011: Fahad Haroon; Katrin Drögemüller; Ulrike Händel; Anna Brunn; Dirk Reinhold; Gopala Nishanth; Werner Mueller; Christian Trautwein; Matthias Ernst; Martina Deckert; et al.
Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6521-31.
2011: Jan Sodenkamp; Jochen Behrends; Irmgard Förster; Werner Müller; Stefan Ehlers; Christoph Hölscher
gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis.
European journal of cell biology 2011;90(6-7):505-14.
2011: Ashutosh Chaudhry; Robert M Samstein; Piper Treuting; Yuqiong Liang; Marina C Pils; Jan-Michael Heinrich; Robert S Jack; F Thomas Wunderlich; Jens C Brüning; Werner Müller; et al.
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.
Immunity 2011;34(4):566-78.
2011: Usriansyah Hadis; Benjamin Wahl; Olga Schulz; Matthias Hardtke-Wolenski; Angela Schippers; Norbert Wagner; Werner Müller; Tim Sparwasser; Reinhold Förster; Oliver Pabst
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
Immunity 2011;34(2):237-46.
2011: Alexander Gerbaulet; Claudia Wickenhauser; Julia Scholten; Katrin Peschke; Sebastian Drube; Hans-Peter Horny; Thomas Kamradt; Ronald Naumann; Werner Müller; Thomas Krieg; et al.
Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.
Blood 2011;117(6):2012-21.
2011: Ayca Sayi; Esther Kohler; Isabella M Toller; Richard A Flavell; Werner Müller; Axel Roers; Anne Müller
TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):878-90.
2011: Maren Luchtefeld; Christoph Preuss; Frank Rühle; Eskindir P Bogalle; Anika Sietmann; Stefanie Figura; Werner Müller; Karsten Grote; Bernhard Schieffer; Monika Stoll
Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways.
PloS one 2011;6(5):e19427.
2010: Liang-Ping Li; J Christoph Lampert; Xiaojing Chen; Catarina Leitao; Jelena Popović; Werner Müller; Thomas Blankenstein
Transgenic mice with a diverse human T cell antigen receptor repertoire.
Nature medicine 2010;16(9):1029-34.
2010: Denise Hilfiker-Kleiner; Praphulla Shukla; Gunnar Klein; Arnd Schaefer; Britta Stapel; Melanie Hoch; Werner Müller; Michaela Scherr; Gregor Theilmeier; Matthias Ernst; et al.
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
Circulation 2010;122(2):145-55.
2010: Tina Lucas; Ari Waisman; Rajeev Ranjan; Jürgen Roes; Thomas Krieg; Werner Müller; Axel Roers; Sabine A Eming
Differential roles of macrophages in diverse phases of skin repair.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3964-77.
2010: Daisuke Kitamura; Akira Kudo; Stefan Schaal; Werner Müller; Fritz Melchers; Klaus Rajewsky
Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1130-8.
2010: Marina C Pils; Fabio Pisano; Nicolas Fasnacht; Jan-Michael Heinrich; Lothar Groebe; Angela Schippers; Björn Rozell; Robert S Jack; Werner Müller
Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model.
European journal of immunology 2010;40(2):443-8.
2009: Yumi Ueki; Yun-Zheng Le; Srinivas Chollangi; Werner Muller; John D Ash
Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(50):21389-94.
2009: Gustavo Salguero; Harald Schuett; Joanna Jagielska; René Schley; Ezequiel Tallone; Maren Luchtefeld; Helmut Drexler; Werner Müller; Karsten Grote; Bernhard Schieffer
Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation.
Hypertension 2009;54(5):1035-42.
2009: Manfred Andratsch; Norbert Mair; Cristina E Constantin; Nadja Scherbakov; Camilla Benetti; Serena Quarta; Christian Vogl; Claudia A Sailer; Nurcan Uceyler; Johannes Brockhaus; et al.
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13473-83.
2009: Matthias Stehr; Marina C Greweling; Sabine Tischer; Mahavir Singh; Helmut Blöcker; David A Monner; Werner Müller
Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages.
Laboratory animals 2009;43(4):362-70.
2009: Angela Schippers; Christoph Leuker; Oliver Pabst; Annika Kochut; Blair Prochnow; Achim D Gruber; Euphemia Leung; Geoffrey W Krissansen; Norbert Wagner; Werner Müller
Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.
Gastroenterology 2009;137(3):924-33.
2009: Rajat Madan; Filiz Demircik; Sangeetha Surianarayanan; Jessica L Allen; Senad Divanovic; Aurelien Trompette; Nir Yogev; Yuanyuan Gu; Marat Khodoun; David Hildeman; et al.
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2312-20.
2009: Nicolas Fasnacht; Marina C Greweling; Mariela Bollati-Fogolín; Angela Schippers; Werner Müller
T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection.
European journal of immunology 2009;39(8):2173-83.
2009: N Strebe; A Guse; M Schüngel; T Schirrmann; M Hafner; T Jostock; M Hust; W Müller; S Dübel
Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies.
Journal of immunological methods 2009;341(1-2):30-40.
2009: H Fuchs; V Gailus-Durner; T Adler; J A Aguilar Pimentel; L Becker; I Bolle; M Brielmeier; J Calzada-Wack; C Dalke; N Ehrhardt; et al.
The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.
Current pharmaceutical biotechnology 2009;10(2):236-43.
2009: Christian Wahl; Werner Müller; Frank Leithäuser; Guido Adler; Franz Oswald; Jörg Reimann; Reinhold Schirmbeck; Anne Seier; Johannes Martin Weiss; Blair Prochnow; et al.
IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):802-10.
2008: Zoe Waibler; Martina Anzaghe; Abdo Konur; Shizuo Akira; Werner Müller; Ulrich Kalinke
Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.
European journal of immunology 2008;38(11):3127-37.
2008: Friederike Frommer; Tobias J A J Heinen; F Thomas Wunderlich; Nir Yogev; Thorsten Buch; Axel Roers; Estelle Bettelli; Werner Müller; Stephen M Anderton; Ari Waisman
Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5748-59.
2008: Leif E Sander; Florian Obermeier; Uta Dierssen; Daniela C Kroy; Anurag K Singh; Ursula Seidler; Konrad L Streetz; Holger H Lutz; Werner Müller; Frank Tacke; et al.
Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3586-94.
2008: Katrin Drögemüller; Ulrike Helmuth; Anna Brunn; Monika Sakowicz-Burkiewicz; David H Gutmann; Werner Mueller; Martina Deckert; Dirk Schlüter
Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2683-93.
2008: Nicolas Fasnacht; Werner Müller
Conditional gp130 deficient mouse mutants.
Seminars in cell & developmental biology 2008;19(4):379-84.
2008: Monica Sanchez-Ruiz; Laura Wilden; Werner Müller; Werner Stenzel; Anna Brunn; Hrvoje Miletic; Dirk Schlüter; Martina Deckert
Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8421-33.
2008: Cornelia Hömig-Hölzel; Caroline Hojer; Julia Rastelli; Stefano Casola; Lothar J Strobl; Werner Müller; Leticia Quintanilla-Martinez; Andreas Gewies; Jürgen Ruland; Klaus Rajewsky; et al.
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
The Journal of experimental medicine 2008;205(6):1317-29.
2008: Hiroshi Kida; Michael L Mucenski; Angela R Thitoff; Timothy D Le Cras; Kwon-Sik Park; Machiko Ikegami; Werner Müller; Jeffrey A Whitsett
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
The American journal of pathology 2008;172(6):1542-54.
2008: Maria Apostolaki; Menelaos Manoloukos; Manolis Roulis; Marc-André Wurbel; Werner Müller; Konstantinos A Papadakis; Dimitris L Kontoyiannis; Bernard Malissen; George Kollias
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.
Gastroenterology 2008;134(7):2025-35.
2008: Enge Sudarman; Mariela Bollati-Fogolín; Martin Hafner; Werner Müller; Jürgen Scheller; Stefan Rose-John; Jutta Eichler
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Chemical biology & drug design 2008;71(5):494-500.
2008: Angela Schippers; Silke Mateika; Blair Prochnow; Achim D Gruber; Werner Müller; Ursula Frischmann
Susceptibility of four inbred mouse strains to a low-pathogenic isolate of Yersinia enterocolitica.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(4):279-91.
2008: Yuri P Rubtsov; Jeffrey P Rasmussen; Emil Y Chi; Jason Fontenot; Luca Castelli; Xin Ye; Piper Treuting; Lisa Siewe; Axel Roers; William R Henderson; et al.
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.
Immunity 2008;28(4):546-58.
2008: Julia Scholten; Karin Hartmann; Alexander Gerbaulet; Thomas Krieg; Werner Müller; Giuseppe Testa; Axel Roers
Mast cell-specific Cre/loxP-mediated recombination in vivo.
Transgenic research 2008;17(2):307-15.
2008: Simon Berberich; Sabrina Dähne; Angela Schippers; Thorsten Peters; Werner Müller; Elisabeth Kremmer; Reinhold Förster; Oliver Pabst
Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2196-203.
2008: Julia Rastelli; Cornelia Hömig-Hölzel; Jane Seagal; Werner Müller; Andrea C Hermann; Klaus Rajewsky; Ursula Zimber-Strobl
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.
Blood 2008;111(3):1448-55.
2007: Niklas Czeloth; Angela Schippers; Norbert Wagner; Werner Müller; Birgit Küster; Günter Bernhardt; Reinhold Förster
Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5855-63.
2007: Anne Fleige; Siegfried Alberti; Lothar Gröbe; Ursula Frischmann; Robert Geffers; Werner Müller; Alfred Nordheim; Angela Schippers
Serum response factor contributes selectively to lymphocyte development.
The Journal of biological chemistry 2007;282(33):24320-8.
2007: Ida Retter; Christophe Chevillard; Maren Scharfe; Ansgar Conrad; Martin Hafner; Tschong-Hun Im; Monika Ludewig; Gabriele Nordsiek; Simone Severitt; Stephanie Thies; et al.
Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2419-27.
2007: Maren Luchtefeld; Heribert Schunkert; Monika Stoll; Tina Selle; Rachel Lorier; Karsten Grote; Christian Sagebiel; Kumaravelu Jagavelu; Uwe J F Tietge; Ulrike Assmus; et al.
Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.
The Journal of experimental medicine 2007;204(8):1935-44.
2007: Michael K Maier; Sebastian Seth; Niklas Czeloth; Quan Qiu; Inga Ravens; Elisabeth Kremmer; Maria Ebel; Werner Müller; Oliver Pabst; Reinhold Förster; et al.
The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens.
European journal of immunology 2007;37(8):2214-25.
2007: John M Hancock; Niels C Adams; Vassilis Aidinis; Andrew Blake; Molly Bogue; Steve D M Brown; Elissa J Chesler; Duncan Davidson; Christopher Duran; et al.
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(3):157-63.
2006: Werner Müller
Dissecting the cytokine network.
Cellular immunology 2006;244(2):162-4.
2006: Lisa Siewe; Mariela Bollati-Fogolin; Claudia Wickenhauser; Thomas Krieg; Werner Müller; Axel Roers
Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA.
European journal of immunology 2006;36(12):3248-55.
2006: Johannes Lutz; Werner Müller; Hans-Martin Jäck
VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7007-14.
2006: B Harr; C Voolstra; T J A J Heinen; J F Baines; R Rottscheidt; S Ihle; W Müller; F Bonhomme; D Tautz
A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus.
Journal of evolutionary biology 2006;19(5):1486-96.
2006: Thorsten Peters; Wilhelm Bloch; Claudia Wickenhauser; Samir Tawadros; Tsvetelina Oreshkova; Daniel Kess; Thomas Krieg; Werner Müller; Karin Scharffetter-Kochanek
Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice.
Journal of leukocyte biology 2006;80(3):599-607.
2006: Ruth Janoschek; Leona Plum; Linda Koch; Heike Münzberg; Sabrina Diano; Marya Shanabrough; Werner Müller; Tamas L Horvath; Jens C Brüning
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10707-12.
2006: Ursula Frischmann; Werner Müller
Nine fluorescence parameter analysis on a four-color fluorescence activated flow cytometer.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2006;69(3):124-6.
2006: Oliver Pabst; Heike Herbrand; Stefanie Willenzon; Tim Worbs; Angela Schippers; Werner Müller; Günter Bernhardt; Reinhold Förster
Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1474-80.
2005: Mariela Bollati-Fogolín; Werner Müller
Virus free, cell-based assay for the quantification of murine type I interferons.
Journal of immunological methods 2005;306(1-2):169-75.
2005: Maria Strassburger; Wilhelm Bloch; Silke Sulyok; Jutta Schüller; Alexander F Keist; Annette Schmidt; Jutta Wenk; Thorsten Peters; Meinhard Wlaschek; Jacek Lenart; et al.
Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
Free radical biology & medicine 2005;38(11):1458-70.
2005: Ida Retter; Hans Helmar Althaus; Richard Münch; Werner Müller
VBASE2, an integrative V gene database.
Nucleic acids research 2005;33(Database issue):D671-4.
2004: Axel Roers; Lisa Siewe; Elke Strittmatter; Martina Deckert; Dirk Schlüter; Werner Stenzel; Achim D Gruber; Thomas Krieg; Klaus Rajewsky; Werner Müller
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
The Journal of experimental medicine 2004;200(10):1289-97.
2004: Johan Auwerx; Phil Avner; Richard Baldock; Andrea Ballabio; Rudi Balling; Mariano Barbacid; Anton Berns; Allan Bradley; Steve Brown; Peter Carmeliet; et al.
The European dimension for the mouse genome mutagenesis program.
Nature genetics 2004;36(9):925-7.
2004: Christian A J Vosshenrich; Ana Cumano; Werner Müller; James P Di Santo; Paulo Vieira
Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(30):11070-5.
2004: Martin Hafner; Jutta Wenk; Arianna Nenci; Manolis Pasparakis; Karin Scharffetter-Kochanek; Neil Smyth; Thorsten Peters; Daniel Kess; Olaf Holtkötter; Pierre Shephard; et al.
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein.
Genesis (New York, N.Y. : 2000) 2004;38(4):176-81.
2003: Daniel Kess; Thorsten Peters; Jan Zamek; Claudia Wickenhauser; Samir Tawadros; Karin Loser; Georg Varga; Stephan Grabbe; Roswitha Nischt; Cord Sunderkötter; et al.
CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5697-706.
2003: G Fingerle-Rowson; O Petrenko; C N Metz; T G Forsthuber; R Mitchell; R Huss; U Moll; W Müller; R Bucala
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9354-9.
2003: Konrad L Streetz; Torsten Wüstefeld; Christian Klein; Karl-Josef Kallen; Francois Tronche; Ullrich A K Betz; Günther Schütz; Michael P Manns; Werner Müller; Christian Trautwein
Lack of gp130 expression in hepatocytes promotes liver injury.
Gastroenterology 2003;125(2):532-43.
2003: Christian A J Vosshenrich; Ana Cumano; Werner Müller; James P Di Santo; Paulo Vieira
Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development.
Nature immunology 2003;4(8):773-9.
2003: Konrad L Streetz; Frank Tacke; Ludger Leifeld; Torsten Wüstefeld; Andrea Graw; Christian Klein; Kenjii Kamino; Ulrich Spengler; Hans Kreipe; Stefan Kubicka; et al.
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.
Hepatology (Baltimore, Md.) 2003;38(1):218-29.
2003: Thomas Ranson; Christian A J Vosshenrich; Erwan Corcuff; Odile Richard; Werner Müller; James P Di Santo
IL-15 is an essential mediator of peripheral NK-cell homeostasis.
Blood 2003;101(12):4887-93.
2003: Martina Deckert; Sonja Lütjen; Christoph E Leuker; Lai-Yu Kwok; Andreas Strack; Werner Müller; Norbert Wagner; Dirk Schlüter
Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis.
European journal of immunology 2003;33(5):1418-28.
2003: Torsten Wuestefeld; Christian Klein; Konrad L Streetz; Ulrich Betz; Jörg Lauber; Jan Buer; Michael P Manns; Werner Müller; Christian Trautwein
Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.
The Journal of biological chemistry 2003;278(13):11281-8.
2002: Richard Kellersmann; Andrew Lazarovits; David Grant; Bertha Garcia; Bosco Chan; Anne Kellersmann; Hao Wang; Anthony Jevnikar; Norbert Wagner; Werner Müller; et al.
Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice.
Transplantation 2002;74(9):1327-34.
2002: Xueying Sun; Haiquan Qiao; Jinyang Shi; Jagat R Kanwar; Werner Mueller; Norbert Wagner; Geoffrey W Krissansen
Beta7 integrins contribute to skin graft rejection.
Transplantation 2002;74(8):1202-3.
2002: B C Sydora; N Wagner; J Lohler; G Yakoub; M Kronenberg; W Muller; R Aranda
beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis.
Clinical and experimental immunology 2002;129(1):35-42.
2002: Olaf Holtkötter; Bernhard Nieswandt; Neil Smyth; Werner Müller; Martin Hafner; Valerie Schulte; Thomas Krieg; Beate Eckes
Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.
The Journal of biological chemistry 2002;277(13):10789-94.
2001: T Alonzi; G Middleton; S Wyatt; V Buchman; U A Betz; W Müller; P Musiani; V Poli; A M Davies
Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons.
Molecular and cellular neurosciences 2001;18(3):270-82.
2001: C E Leuker; M Labow; W Müller; N Wagner
Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response.
The Journal of experimental medicine 2001;193(6):755-68.
2001: N A Kuklin; L Rott; N Feng; M E Conner; N Wagner; W Müller; H B Greenberg
Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1894-902.
2000: N A Kuklin; L Rott; J Darling; J J Campbell; M Franco; N Feng; W Müller; N Wagner; J Altman; E C Butcher; et al.
alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus.
The Journal of clinical investigation 2000;106(12):1541-52.
2000: R Kellersmann; R Zhong; D Grant; B Garcia; A Blömer; W Liu; N Wagner; W Müller; A Jevnikar; A Thiede; et al.
Despite high levels of lymphocyte homing receptor alpha4beta7 integrin after small bowel allotransplantation, it is not critical for rejection.
Transplantation proceedings 2000;32(6):1267-8.
2000: S Sarnacki; F Auber; C Crétolle; C Camby; M Cavazzana-Calvo; W Müller; N Wagner; N Brousse; Y Révillon; A Fischer; et al.
Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice.
Gut 2000;47(1):97-104.
2000: D Artis; N E Humphreys; C S Potten; N Wagner; W Müller; J R McDermott; R K Grencis; K J Else
Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection.
European journal of immunology 2000;30(6):1656-64.
2000: C A Vosshenrich; L I Sharara; D Guy-Grand; K Rajewsky; W Müller; J P Di Santo
Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen.
European journal of immunology 2000;30(6):1614-22.
2000: J R Kanwar; J E Harrison; D Wang; E Leung; W Mueller; N Wagner; G W Krissansen
Beta7 integrins contribute to demyelinating disease of the central nervous system.
Journal of neuroimmunology 2000;103(2):146-52.
2000: G Esposito; G Texido; U A Betz; H Gu; W Müller; U Klein; K Rajewsky
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1166-71.
1999: L Lefrançois; C M Parker; S Olson; W Muller; N Wagner; M P Schön; L Puddington
The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response.
The Journal of experimental medicine 1999;189(10):1631-8.
1999: H Hirota; J Chen; U A Betz; K Rajewsky; Y Gu; J Ross; W Müller; K R Chien
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.
Cell 1999;97(2):189-98.
1999: T I Novobrantseva; V M Martin; R Pelanda; W Müller; K Rajewsky; A Ehlich
Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice.
The Journal of experimental medicine 1999;189(1):75-88.
1999: M P Lefranc; V Giudicelli; C Ginestoux; J Bodmer; W Müller; R Bontrop; M Lemaitre; A Malik; V Barbié; D Chaume
IMGT, the international ImMunoGeneTics database.
Nucleic acids research 1999;27(1):209-12.
1998: D A Steeber; M L Tang; X Q Zhang; W Müller; N Wagner; T F Tedder
Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6638-47.
1998: U A Betz; W Bloch; M van den Broek; K Yoshida; T Taga; T Kishimoto; K Addicks; K Rajewsky; W Müller
Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
The Journal of experimental medicine 1998;188(10):1955-65.
1998: N Wagner; J Löhler; T F Tedder; K Rajewsky; W Müller; D A Steeber
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
European journal of immunology 1998;28(11):3832-9.
1998: E J Kunkel; C L Ramos; D A Steeber; W Müller; N Wagner; T F Tedder; K Ley
The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2449-56.
1998: U A Betz; W Müller
Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation.
International immunology 1998;10(8):1175-84.
1998: T A Wynn; A W Cheever; M E Williams; S Hieny; P Caspar; R Kühn; W Müller; A Sher
IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4473-80.
1998: V Giudicelli; D Chaume; G Mennessier; H H Althaus; W Müller; J Bodmer; A Malik; M P Lefranc
IMGT, the international ImMunoGeneTics database: a new design for immunogenetics data access.
Studies in health technology and informatics 1998;52 Pt 1():351-5.
1998: N Wagner; W Müller
Functions of alpha 4- and beta 7-integrins in hematopoiesis, lymphocyte trafficking and organ development.
Current topics in microbiology and immunology 1998;231():23-32.
1998: M P Lefranc; V Giudicelli; C Busin; J Bodmer; W Müller; R Bontrop; M Lemaitre; A Malik; D Chaume
IMGT, the International ImMunoGeneTics database.
Nucleic acids research 1998;26(1):297-303.
1997: B A Croy; A A Ashkar; R A Foster; J P DiSanto; J Magram; D Carson; S J Gendler; M J Grusby; N Wagner; W Muller; et al.
Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
Journal of reproductive immunology 1997;35(2):111-33.
1997: T A Wynn; R Morawetz; T Scharton-Kersten; S Hieny; H C Morse; R Kühn; W Müller; A W Cheever; A Sher
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):5014-23.
1997: F Schwenk; B Sauer; N Kukoc; R Hoess; W Müller; C Kocks; R Kühn; K Rajewsky
Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
Journal of immunological methods 1997;207(2):203-12.
1997: L I Sharara; C A Vosshenrich; W Müller; J P DiSanto
On the role of the common cytokine receptor gamma chain in B-cell vs. T-cell development.
Research in immunology 1997;148(7):449-53.
1997: R Kühn; W Müller
Gene targeting in immunology.
Research in immunology 1997;148(7):447-9.
1997: M L Santiago; L Fossati; C Jacquet; W Müller; S Izui; L Reininger
Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
The Journal of experimental medicine 1997;185(1):65-70.
1997: V Giudicelli; D Chaume; J Bodmer; W Müller; C Busin; S Marsh; R Bontrop; L Marc; A Malik; M P Lefranc
IMGT, the international ImMunoGeneTics database.
Nucleic acids research 1997;25(1):206-11.
1996: A Linke; R Kühn; W Müller; N Honarvar; C Li; J Langhorne
Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection.
Experimental parasitology 1996;84(2):253-63.
1996: R A Morawetz; L Gabriele; L V Rizzo; N Noben-Trauth; R Kühn; K Rajewsky; W Müller; T M Doherty; F Finkelman; R L Coffman; et al.
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
The Journal of experimental medicine 1996;184(5):1651-61.
1996: U A Betz; C A Vosshenrich; K Rajewsky; W Müller
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
Current biology : CB 1996;6(10):1307-16.
1996: S Beissert; J Hosoi; R Kühn; K Rajewsky; W Müller; R D Granstein
Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
The Journal of investigative dermatology 1996;107(4):553-7.
1996: D J Berg; N Davidson; R Kühn; W Müller; S Menon; G Holland; L Thompson-Snipes; M W Leach; D Rennick
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
The Journal of clinical investigation 1996;98(4):1010-20.
1996: G Texidó; H Jacobs; M Meiering; R Kühn; J Roes; W Müller; S Gilfillan; H Fujiwara; H Kikutani; N Yoshida; et al.
Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
European journal of immunology 1996;26(8):1966-9.
1996: K Rajewsky; H Gu; R Kühn; U A Betz; W Müller; J Roes; F Schwenk
Conditional gene targeting.
The Journal of clinical investigation 1996;98(3):600-3.
1996: N Wagner; J Löhler; E J Kunkel; K Ley; E Leung; G Krissansen; K Rajewsky; W Müller
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
Nature 1996;382(6589):366-70.
1996: R T Gazzinelli; M Wysocka; S Hieny; T Scharton-Kersten; A Cheever; R Kühn; W Müller; G Trinchieri; A Sher
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):798-805.
1996: N J Davidson; M W Leach; M M Fort; L Thompson-Snipes; R Kühn; W Müller; D J Berg; D M Rennick
T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.
The Journal of experimental medicine 1996;184(1):241-51.
1996: D Löffert; A Ehlich; W Müller; K Rajewsky
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.
Immunity 1996;4(2):133-44.
1995: J P Di Santo; R Kühn; W Müller
Common cytokine receptor gamma chain (gamma c)-dependent cytokines: understanding in vivo functions by gene targeting.
Immunological reviews 1995;148():19-34.
1995: D J Berg; R Kühn; K Rajewsky; W Müller; S Menon; N Davidson; G Grünig; D Rennick
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
The Journal of clinical investigation 1995;96(5):2339-47.
1995: M F Bachmann; H Schorle; R Kühn; W Müller; H Hengartner; R M Zinkernagel; I Horak
Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Journal of virology 1995;69(8):4842-6.
1995: A Tarakhovsky; S B Kanner; J Hombach; J A Ledbetter; W Müller; N Killeen; K Rajewsky
A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
Science (New York, N.Y.) 1995;269(5223):535-7.
1995: D J Berg; M W Leach; R Kühn; K Rajewsky; W Müller; N J Davidson; D Rennick
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
The Journal of experimental medicine 1995;182(1):99-108.
1995: J Roes; W Müller; K Rajewsky
Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice.
Journal of immunological methods 1995;183(2):231-7.
1995: X Q Wei; I G Charles; A Smith; J Ure; G J Feng; F P Huang; D Xu; W Muller; S Moncada; F Y Liew
Altered immune responses in mice lacking inducible nitric oxide synthase.
Nature 1995;375(6530):408-11.
1994: Y R Zou; W Müller; H Gu; K Rajewsky
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.
Current biology : CB 1994;4(12):1099-103.
1994: E Schmitt; T Germann; S Goedert; P Hoehn; C Huels; S Koelsch; R Kühn; W Müller; N Palm; E Rüde
IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):3989-96.
1994: R A Morawetz; T M Doherty; N A Giese; J W Hartley; W Müller; R Kühn; K Rajewsky; R Coffman; H C Morse
Resistance to murine acquired immunodeficiency syndrome (MAIDS)
Science (New York, N.Y.) 1994;265(5169):264-6; author reply 267.
1994: A Ehlich; V Martin; W Müller; K Rajewsky
Analysis of the B-cell progenitor compartment at the level of single cells.
Current biology : CB 1994;4(7):573-83.
1994: A Tarakhovsky; W Müller; K Rajewsky
Lymphocyte populations and immune responses in CD5-deficient mice.
European journal of immunology 1994;24(7):1678-84.
1994: J Schmitz; A Thiel; R Kühn; K Rajewsky; W Müller; M Assenmacher; A Radbruch
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
The Journal of experimental medicine 1994;179(4):1349-53.
1994: D Löffert; S Schaal; A Ehlich; R R Hardy; Y R Zou; W Müller; K Rajewsky
Early B-cell development in the mouse: insights from mutations introduced by gene targeting.
Immunological reviews 1994;137():135-53.
1994: B Sadlack; R Kühn; H Schorle; K Rajewsky; W Müller; I Horak
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
European journal of immunology 1994;24(1):281-4.
1993: R Kühn; J Löhler; D Rennick; K Rajewsky; W Müller
Interleukin-10-deficient mice develop chronic enterocolitis.
Cell 1993;75(2):263-74.
1993: W Müller; K Rajewsky; R Kühn
Interleukin-4-deficient mice.
Research in immunology 1993;144(8):637-8.
1993: A Ehlich; S Schaal; H Gu; D Kitamura; W Müller; K Rajewsky
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.
Cell 1993;72(5):695-704.
1993: L M Leal; D W Moss; R Kuhn; W Müller; F Y Liew
Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection.
European journal of immunology 1993;23(2):566-9.
1992: C L Schultz; P Rothman; R Kühn; M Kehry; W Müller; K Rajewsky; F Alt; R L Coffman
T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):60-4.
1992: D Kitamura; A Kudo; S Schaal; W Müller; F Melchers; K Rajewsky
A critical role of lambda 5 protein in B cell development.
Cell 1992;69(5):823-31.
1992: C Platzer; G Richter; K Uberla; W Müller; H Blöcker; T Diamantstein; T Blankenstein
Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction.
European journal of immunology 1992;22(5):1179-84.
1991: R Kühn; K Rajewsky; W Müller
Generation and analysis of interleukin-4 deficient mice.
Science (New York, N.Y.) 1991;254(5032):707-10.
1991: I Förster; W Müller; B Schittek; K Rajewsky
Generation of long-lived B cells in germ-free mice.
European journal of immunology 1991;21(7):1779-82.
1991: H Gu; D Tarlinton; W Müller; K Rajewsky; I Förster
Most peripheral B cells in mice are ligand selected.
The Journal of experimental medicine 1991;173(6):1357-71.
1991: T Blankenstein; Z H Qin; K Uberla; W Müller; H Rosen; H D Volk; T Diamantstein
Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.
The Journal of experimental medicine 1991;173(5):1047-52.
1991: W Müller; R Kühn; K Rajewsky
Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
European journal of immunology 1991;21(4):921-5.
1991: I Förster; H Gu; W Müller; M Schmitt; D Tarlinton; K Rajewsky
CD5 B cells in the mouse.
Current topics in microbiology and immunology 1991;173():247-51.
1990: T Blankenstein; W Q Li; W Müller; T Diamantstein
Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity.
European journal of immunology 1990;20(4):935-8.
1990: S Miltenyi; W Müller; W Weichel; A Radbruch
High gradient magnetic cell separation with MACS.
Cytometry 1990;11(2):231-8.
1989: W Müller; U Rüther; P Vieira; J Hombach; M Reth; K Rajewsky
Membrane-bound IgM obstructs B cell development in transgenic mice.
European journal of immunology 1989;19(5):923-8.
1988: T Blankenstein; E Winter; W Müller
A retroviral expression vector containing murine immunoglobulin heavy chain promoter/enhancer.
Nucleic acids research 1988;16(22):10939.
1988: U Rüther; W Müller; T Sumida; T Tokuhisa; K Rajewsky; E F Wagner
c-fos expression interferes with thymus development in transgenic mice.
Cell 1988;53(6):847-56.
1986: A Radbruch; W Müller; K Rajewsky
Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3954-7.
1986: C Göttlinger; K L Meyer; W Weichel; W Müller; B Raftery; A Radbruch
Cell-cooling in flow cytometry by Peltier elements.
Cytometry 1986;7(3):295-7.
1986: A Radbruch; C Burger; S Klein; W Müller
Control of immunoglobulin class switch recombination.
Immunological reviews 1986;89():69-83.
1985: W Müller; R Kühn; W Goldmann; H Tesch; F I Smith; A Radbruch; K Rajewsky
Signal requirements for growth and differentiation of activated murine B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(2):1213-9.