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Keith Hoek

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Daniel S Widmer; Marie C Zipser; Delphine Javelaud; Alain Mauviel; Natalie Schlegel; Benedetta C Belloni; Phil F Cheng; Reinhard Dummer; Ossia M Eichhoff; Keith Hoek
Systematic classification of melanoma cells by phenotype-specific gene expression mapping.
Ossia M Eichhoff; Laurence Denat; Reinhard Dummer; Thomas Kirchner; Lydia Kriegl; Lionel Larue; Ashani T Weeraratna; Daniel S Widmer; Mai Xu; Marie C Zipser; Keith Hoek
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.
Marie C Zipser; Ossia M Eichhoff; Daniel S Widmer; Natalie Schlegel; Nicola L Schoenewolf; Darrin Stuart; Weihua Liu; Humphrey Gardner; Paul D Smith; Paolo Nuciforo; Reinhard Dummer; Keith Hoek
A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status.

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All Publications

2012: Daniel S Widmer; Marie C Zipser; Delphine Javelaud; Alain Mauviel; Natalie Schlegel; Benedetta C Belloni; Phil F Cheng; Reinhard Dummer; Ossia M Eichhoff; Keith Hoek
Systematic classification of melanoma cells by phenotype-specific gene expression mapping.
Pigment cell & melanoma research 2012;25(3):343-53.
2011: Ossia M Eichhoff; Laurence Denat; Reinhard Dummer; Thomas Kirchner; Lydia Kriegl; Lionel Larue; Ashani T Weeraratna; Daniel S Widmer; Mai Xu; Marie C Zipser; Keith Hoek
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.
Pigment cell & melanoma research 2011;24(4):631-42.
2011: Marie C Zipser; Ossia M Eichhoff; Daniel S Widmer; Natalie Schlegel; Nicola L Schoenewolf; Darrin Stuart; Weihua Liu; Humphrey Gardner; Paul D Smith; Paolo Nuciforo; Reinhard Dummer; Keith Hoek
A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status.
Pigment cell & melanoma research 2011;24(2):326-33.
2010: Keith Hoek; Colin R Goding
Cancer stem cells versus phenotype-switching in melanoma.
Pigment cell & melanoma research 2010;23(6):746-59.
2010: Ossia M Eichhoff; Marie C Zipser; Mai Xu; Ashani T Weeraratna; Daniela Mihic; Reinhard Dummer; Keith Hoek
The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report.
Melanoma research 2010;20(4):349-55.
2009: J L Orgaz; O Ladhani; Keith Hoek; A Fernández-Barral; D Mihic; Oscar Aguilera; E A Seftor; Antonio Bernad; J L Rodríguez-Peralto; M J C Hendrix; Olga V Volpert; B Jiménez
'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'.
Oncogene 2009;28(47):4147-61.
2009: Michael O'Connell; Jennifer Fiori; Emily K Kershner; Brittany P Frank; Fred E Indig; Dennis D Taub; Keith Hoek; Ashani T Weeraratna
Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells.
The Journal of biological chemistry 2009;284(42):28704-12.
2009: Anita Grigoriadis; Otavia L Caballero; Keith Hoek; Leonard da Silva; Yao-Tseng Chen; Sandra J Shin; Achim A Jungbluth; Lance D Miller; David Clouston; Jonathan Cebon; Lloyd J Old; Sunil R Lakhani; Andrew J G Simpson; A Munro Neville
CT-X antigen expression in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13493-8.
2009: Natalie Schlegel; Ossia M Eichhoff; Silvio Hemmi; Sabine Werner; Reinhard Dummer; Keith Hoek
Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells.
Pigment cell & melanoma research 2009;22(4):445-53.
2009: Michael O'Connell; Jennifer Fiori; Katherine M Baugher; Fred E Indig; Amanda D French; Tura Camilli; Brittany P Frank; Rachel Earley; Keith Hoek; Joanne H Hasskamp; E George Elias; Dennis D Taub; Michel Bernier; Ashani T Weeraratna
Wnt5A activates the calpain-mediated cleavage of filamin A.
The Journal of investigative dermatology 2009;129(7):1782-9.
2009: Jennifer Fiori; Tie-Nian Zhu; Michael O'Connell; Keith Hoek; Fred E Indig; Brittany P Frank; Christa Morris; Sutapa Kole; Joanne Hasskamp; George Elias; Ashani T Weeraratna; Michel Bernier
Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells.
Endocrinology 2009;150(6):2551-60.
2009: Giovanni Almanzar; Purevdorj B Olkhanud; Monica Bodogai; Chiara Dell'Agnola; Dolgor Baatar; Stephen M Hewitt; Claudio Ghimenton; Mohan K Tummala; Ashani T Weeraratna; Keith Hoek; Natalay Kouprina; Vladimir Larionov; Arya Biragyn
Sperm-derived SPANX-B is a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):1954-63.
2009: Keith Hoek
Melanoma progression, gene expression and DNA microarrays.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia 2009;144(1):39-49.
2009: Keith Hoek; Ossia M Eichhoff; Daniel Widmer; Reinhard Dummer
Stemming the flood.
Pigment cell & melanoma research 2009;22(1):6-7.
2009: Andreas Winklmeier; Ina Poser; Keith Hoek; Anja Bosserhoff
Loss of full length CtBP1 expression enhances the invasive potential of human melanoma.
BMC cancer 2009;9():52.
2009: Christian Mnich; Keith Hoek; Leila V Virkki; Arpad Farkas; Christa Dudli; Elisabeth Laine; Mirjana Urosevic-Maiwald; Reinhard Dummer
Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls.
Experimental dermatology 2009;18(1):69-77.
2008: Samudra K Dissanayake; Purevdorj B Olkhanud; Michael O'Connell; Arnell Carter; Amanda D French; Tura Camilli; Chineye D Emeche; Kyle J Hewitt; Devin T Rosenthal; Poloko D Leotlela; Michael S Wade; Sherry W Yang; Larry Brant; Brian J Nickoloff; Jane L Messina; Arya Biragyn; Keith Hoek; Dennis D Taub; Dan Longo; vernon sondak; Stephen M Hewitt; Ashani T Weeraratna
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
Cancer research 2008;68(24):10205-14.
2008: Keith Hoek; Natalie Schlegel; Ossia M Eichhoff; Daniel S Widmer; Christian Praetorius; Steingrimur O Einarsson; Sigridur Valgeirsdottir; Kristin Bergsteinsdottir; Alexander Schepsky; Reinhard Dummer; Eirikur Steingrimsson
Novel MITF targets identified using a two-step DNA microarray strategy.
Pigment cell & melanoma research 2008;21(6):665-76.
2008: Keith Hoek
Genesifter, leading the blind.
Pigment cell & melanoma research 2008;21(5):588-9.
2008: Keith Hoek; Ossia M Eichhoff; Natalie Schlegel; Udo Döbbeling; Nikita Kobert; Leo Schaerer; Silvio Hemmi; Reinhard Dummer
In vivo switching of human melanoma cells between proliferative and invasive states.
Cancer research 2008;68(3):650-6.
2008: Mirjam Beyeler; Keith Hoek; Reinhard Dummer
Voodoo medicine still going strong: a tale of melanoma, faith, and failure.
Archives of dermatology 2008;144(1):121-2.
2007: Keith Hoek
DNA microarray analyses of melanoma gene expression: a decade in the mines.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2007;20(6):466-84.
2007: Christian Mnich; Keith Hoek; Patrick A Oberholzer; Burkhardt Seifert; Jürg Hafner; Reinhard Dummer; Daniela Mihic
Reduced pSmad2 immunodetection correlates with increased primary melanoma thickness.
Melanoma research 2007;17(2):131-6.
2007: Alexandra E Denk; Marcus Bettstetter; Peter J Wild; Keith Hoek; Frauke Bataille; Wolfgang Dietmaier; Anja Bosserhoff
Loss of maspin expression contributes to a more invasive potential in malignant melanoma.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2007;20(2):112-9.
2006: suzanne CARREIRA; Jane Goodall; Laurence Denat; Mercedes Rodriguez; Paolo Giovanni Nuciforo; Keith Hoek; Alessandro Testori; Lionel Larue; Colin R Goding
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.
Genes & development 2006;20(24):3426-39.
2006: Keith Hoek; Natalie Schlegel; Patricia Brafford; Antje Sucker; Selma Ugurel; Rajiv Kumar; Barbara L Weber; Katherine L Nathanson; David J Phillips; Meenhard Herlyn; Dirk Schadendorf; Reinhard Dummer
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19(4):290-302.
2005: Amanda Pfaff Smith; Keith Hoek; Dorothea Becker
Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas.
Cancer biology & therapy 2005;4(9):1018-29.
2004: Keith Hoek; David L Rimm; Kenneth R Williams; Hongyu Zhao; Stephan Ariyan; Aiping Lin; Harriet M Kluger; Aaron J Berger; Elaine Cheng; Eduardo S. Trombetta; Terence Wu; Michio Niinobe; Kazuaki Yoshikawa; Gregory E Hannigan; Ruth Halaban
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Cancer research 2004;64(15):5270-82.
2003: Reinhard Dummer; Mirjana Urosevic-Maiwald; Werner Kempf; Keith Hoek; Jürg Hafner; Guenter Burg
Imiquimod in basal cell carcinoma: how does it work?
The British journal of dermatology 2003;149 Suppl 66():57-8.
2003: Reinhard Dummer; Mirjana Urosevic-Maiwald; Keith Hoek; Andreas Häffner; Günter Burg
Exploring primary cutaneous B-cell lymphoma by microarray technology.
The Journal of investigative dermatology 2003;120(5):vii-viii.
2002: Alice S W Ma; Kim Moran-Jones; Jianguo Shan; Trent P Munro; Mark J Snee; Keith Hoek; Ross Smith
Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein.
The Journal of biological chemistry 2002;277(20):18010-20.
2000: Jianguo Shan; Kim Moran-Jones; Trent P Munro; Grahame J Kidd; D J Winzor; Keith Hoek; Ross Smith
Binding of an RNA trafficking response element to heterogeneous nuclear ribonucleoproteins A1 and A2.
The Journal of biological chemistry 2000;275(49):38286-95.
1998: Keith Hoek; Grahame J Kidd; John H Carson; Ross Smith
hnRNP A2 selectively binds the cytoplasmic transport sequence of myelin basic protein mRNA.
Biochemistry 1998;37(19):7021-9.
1997: Keith Hoek; J M Milne; P A Grieve; D A Dionysius; R Smith
Antibacterial activity in bovine lactoferrin-derived peptides.
Antimicrobial agents and chemotherapy 1997;41(1):54-9.